dcGO - A comprehensive domain-centric ontology resource for post-genomic research on functions, phenotypes, diseases and more   
  
  

Disease Ontology (DO): cell type cancer 

(show info)

Jump to [ Top · Hierarchy · Annotations ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term
(+ for parents, - for children)
DO term [DO ID] <#Children> #Domains
(Superfamily|Family)
#Supra-domain
(Single|Duplex|Triple)
+ + + 3:   disease [DOID:4] <8>
+ + 2:   disease of cellular proliferation [DOID:14566] <3>(124|191) (130|120|57)
+ 1:   cancer [DOID:162] <2>(116|181) (121|115|55)
0:   cell type cancer [DOID:0050687] <10>(23|39) (25|27|17)
- 1:   carcinoma [DOID:305] <13>(13|26) (15|19|9)
- 1:   germ cell cancer [DOID:2994] <9>(1|1) (1|0|0)
- 1:   mesenchymal cell neoplasm [DOID:3350] <7>(0|0) (0|0|0)
- 1:   melanoma [DOID:1909] <6>(3|3) (3|2|4)
- 1:   malignant glioma [DOID:3070] <5>(7|8) (7|4|3)
- 1:   sarcoma [DOID:1115] <5>(1|2) (1|2|2)
- 1:   malignant mesothelioma [DOID:1790] <4>(0|1) (0|0|0)
- 1:   mixed cell type cancer [DOID:154] <4>(0|0) (0|0|0)
- 1:   blastoma [DOID:0070003](0|0) (0|0|0)
- 1:   gangliocytoma [DOID:2426](0|0) (0|0|0)

Superfamily

Jump to [ Top · Hierarchy ]

Superfamily

(show details)
SCOP term FDR (all) Annotation (direct or inherited)
Purine and uridine phosphorylases0Direct
Di-copper centre-containing domain0Direct
Integrin beta tail domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Insulin-like0Direct
HSP90 C-terminal domain0Direct
p53 tetramerization domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Synuclein0Direct
FAS1 domain0Direct
PGBD-like0.0004805Direct
Metalloproteases ("zincins"), catalytic domain0.0005188Direct
Hemopexin-like domain0.001775Inherited
Growth factor receptor domain0.004246Inherited
Bcl-2 inhibitors of programmed cell death0.00639Inherited
Protein kinase-like (PK-like)0.04132Inherited
Caspase-like0.06269Inherited
Intermediate filament protein, coiled coil region0.06888Inherited
Prefoldin0.5435Inherited
Thioredoxin-like0.5967Inherited
Ubiquitin-like0.601Inherited
Ran binding protein zinc finger-like0.8435Inherited
HMG-box0.8994Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Family

Jump to [ Top · Hierarchy ]

Family

(show details)
SCOP term FDR (all) Annotation (direct or inherited)
Gelsolin-like0Direct
Neurotrophin0Direct
Integrin beta tail domain0Direct
p53 tetramerization domain0Direct
DEATH effector domain, DED0Direct
HSP90 C-terminal domain0Direct
Tissue inhibitor of metalloproteinases, TIMP0Direct
Integrin beta EGF-like domains0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Transferrin0Direct
Synuclein0Direct
Uteroglobin-like0Direct
p53 DNA-binding domain-like0Direct
Insulin-like0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Hsp90 middle domain0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
FAS1 domain0Direct
L domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Purine and uridine phosphorylases0Direct
MMP N-terminal domain0.0003716Direct
Growth factor receptor domain0.000412Direct
Matrix metalloproteases, catalytic domain0.0008681Direct
Hemopexin-like domain0.001398Inherited
Ephrin receptor ligand binding domain0.003002Inherited
Bcl-2 inhibitors of programmed cell death0.004996Inherited
Platelet-derived growth factor-like0.02187Inherited
Hexokinase0.0455Inherited
Intermediate filament protein, coiled coil region0.06589Inherited
Protein kinases, catalytic subunit0.07157Inherited
Caspase catalytic domain0.07899Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.08934Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1134Inherited
C5 cytosine-specific DNA methylase, DCM0.1585Inherited
Ras-binding domain, RBD0.2414Inherited
Ran binding protein zinc finger-like0.8228Inherited
HMG-box0.8836Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Supra-domain (Single|Duplex|Triple)

Jump to [ Top · Hierarchy ]

Supra-domain (Single)

(
show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
FAS1 domain0Direct
Insulin-like0Direct
Nuclear receptor coactivator interlocking domain0Direct
HSP90 C-terminal domain0Direct
Di-copper centre-containing domain0Direct
Integrin beta tail domain0Direct
Purine and uridine phosphorylases0Direct
Synuclein0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
p53 tetramerization domain0Direct
PGBD-like0.0002957Direct
Metalloproteases ("zincins"), catalytic domain0.0003204Direct
Hemopexin-like domain0.001147Inherited
Growth factor receptor domain0.002863Inherited
Bcl-2 inhibitors of programmed cell death0.00438Inherited
Protein kinase-like (PK-like)0.03111Inherited
Caspase-like0.04841Inherited
Intermediate filament protein, coiled coil region0.05346Inherited
Serine protease inhibitors0.1486Inherited
DNA-glycosylase0.1486Inherited
Prefoldin0.4804Inherited
Thioredoxin-like0.5296Inherited
Ubiquitin-like0.5339Inherited
Ran binding protein zinc finger-like0.7709Inherited
HMG-box0.8274Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

Jump to [ Top · Hierarchy ]

Supra-domain (Duplex) in N- to C-terminal order

(
show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    53850,53850
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    57302,57302
  • 57302 - Snake toxin-like
  • 57302 - Snake toxin-like
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0002957Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.002599Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.004791Inherited
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0.007269Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.01368Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.01984Inherited

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

    Jump to [ Top · Hierarchy ]

    Supra-domain (Triple) in N- to C-terminal order

    (
    show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    55753,55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.001532Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1486Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.1486Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.5138Inherited

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

    Distribution on sTOL

    Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this DO term
    Plot tree as:   Download Newick format tree:
    (show help)
    Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this DO term
    Plot tree as:   Download Newick format tree:   Browsing in TREE OF LIFE:
    (show help)