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Disease Ontology (DO): cell type cancer 

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Root: DO Hierarchy (disease ontology from University of Maryland)

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DO term [DO ID] <#Children> #Domains
(Superfamily|Family)
#Supra-domain
(Single|Duplex|Triple)
+ + + 3:   disease [DOID:4] <8>
+ + 2:   disease of cellular proliferation [DOID:14566] <3>(124|191) (130|118|56)
+ 1:   cancer [DOID:162] <2>(116|181) (121|113|54)
0:   cell type cancer [DOID:0050687] <11>(23|39) (25|27|17)
- 1:   carcinoma [DOID:305] <13>(13|26) (15|19|9)
- 1:   germ cell cancer [DOID:2994] <9>(1|1) (1|0|0)
- 1:   mesenchymal cell neoplasm [DOID:3350] <7>(0|0) (0|0|0)
- 1:   melanoma [DOID:1909] <6>(3|3) (3|2|4)
- 1:   malignant glioma [DOID:3070] <5>(7|8) (7|4|3)
- 1:   sarcoma [DOID:1115] <5>(1|2) (1|2|2)
- 1:   malignant mesothelioma [DOID:1790] <4>(0|1) (0|0|0)
- 1:   mixed cell type cancer [DOID:154] <4>(0|0) (0|0|0)
- 1:   malignant hemangioma [DOID:0080189] <1>(0|0) (0|0|0)
- 1:   blastoma [DOID:0070003](0|0) (0|0|0)
- 1:   gangliocytoma [DOID:2426](0|0) (0|0|0)

Superfamily

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Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
FAS1 domain0Direct
Integrin beta tail domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Synuclein0Direct
Purine and uridine phosphorylases0Direct
Insulin-like0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Di-copper centre-containing domain0Direct
HSP90 C-terminal domain0Direct
PGBD-like0.000494Direct
Metalloproteases ("zincins"), catalytic domain0.0005424Direct
Hemopexin-like domain0.001811Inherited
Growth factor receptor domain0.00442Inherited
Bcl-2 inhibitors of programmed cell death0.006509Inherited
Protein kinase-like (PK-like)0.03793Inherited
Caspase-like0.06374Inherited
Intermediate filament protein, coiled coil region0.06967Inherited
Prefoldin0.547Inherited
Ubiquitin-like0.5565Inherited
Thioredoxin-like0.6008Inherited
Ran binding protein zinc finger-like0.8463Inherited
HMG-box0.9017Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Family

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Family

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SCOP term FDR (all) Annotation (direct or inherited)
DEATH effector domain, DED0Direct
L domain0Direct
Integrin beta EGF-like domains0Direct
FAS1 domain0Direct
Tissue inhibitor of metalloproteinases, TIMP0Direct
Insulin-like0Direct
Synuclein0Direct
p53 DNA-binding domain-like0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Gelsolin-like0Direct
Nuclear receptor coactivator interlocking domain0Direct
Uteroglobin-like0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
Integrin beta tail domain0Direct
HSP90 C-terminal domain0Direct
Neurotrophin0Direct
p53 tetramerization domain0Direct
Hsp90 middle domain0Direct
Purine and uridine phosphorylases0Direct
Retinoblastoma tumor suppressor domains0Direct
Transferrin0Direct
MMP N-terminal domain0.0003804Direct
Growth factor receptor domain0.0004266Direct
Matrix metalloproteases, catalytic domain0.0008862Direct
Hemopexin-like domain0.001426Inherited
Ephrin receptor ligand binding domain0.003071Inherited
Bcl-2 inhibitors of programmed cell death0.005091Inherited
Platelet-derived growth factor-like0.02219Inherited
Hexokinase0.04582Inherited
Protein kinases, catalytic subunit0.06525Inherited
Intermediate filament protein, coiled coil region0.06668Inherited
Caspase catalytic domain0.07982Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1145Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1167Inherited
C5 cytosine-specific DNA methylase, DCM0.1594Inherited
Ras-binding domain, RBD0.2438Inherited
Ran binding protein zinc finger-like0.8252Inherited
HMG-box0.886Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Supra-domain (Single|Duplex|Triple)

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Supra-domain (Single)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
FAS1 domain0Direct
Synuclein0Direct
HSP90 C-terminal domain0Direct
Insulin-like0Direct
Di-copper centre-containing domain0Direct
Integrin beta tail domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Purine and uridine phosphorylases0Direct
p53 tetramerization domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
PGBD-like0.0003036Direct
Metalloproteases ("zincins"), catalytic domain0.0003345Direct
Hemopexin-like domain0.001173Inherited
Growth factor receptor domain0.002984Inherited
Bcl-2 inhibitors of programmed cell death0.004471Inherited
Protein kinase-like (PK-like)0.0284Inherited
Caspase-like0.04918Inherited
Intermediate filament protein, coiled coil region0.0541Inherited
DNA-glycosylase0.1501Inherited
Serine protease inhibitors0.1501Inherited
Prefoldin0.4838Inherited
Ubiquitin-like0.4922Inherited
Thioredoxin-like0.5339Inherited
Ran binding protein zinc finger-like0.7733Inherited
HMG-box0.8297Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Duplex) in N- to C-terminal order

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    57302,57302
  • 57302 - Snake toxin-like
  • 57302 - Snake toxin-like
  • 0Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    53850,53850
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0003036Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.002653Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.004895Inherited
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0.007398Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.01387Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.02012Inherited

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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    Supra-domain (Triple) in N- to C-terminal order

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    55753,55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0Direct
    53067,53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.001563Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1501Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.1501Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.5164Inherited

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

    Distribution on sTOL

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