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Mammalian Phenotype (MP): embryonic lethality 

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term
(+ for parents, - for children)
MP term [MP ID] <#Children> #Domains
(Superfamily|Family)
#Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   mortality/aging [MP:0010768] <4>(82|115) (89|69|51)
+ + 2:   preweaning lethality [MP:0010770] <4>(47|78) (55|47|38)
+ + 2:   abnormal survival [MP:0010769] <10>(59|91) (67|57|40)
+ 1:   prenatal lethality [MP:0002080] <5>(26|48) (30|24|16)
0:   embryonic lethality [MP:0008762] <4>(15|29) (16|12|7)
- 1:   embryonic lethality during organogenesis [MP:0006207] <2>(4|7) (4|4|4)
- 1:   embryonic lethality prior to tooth bud stage [MP:0013293] <1>(9|14) (10|7|3)
- 1:   embryonic lethality, complete penetrance [MP:0011092](0|2) (0|1|0)
- 1:   embryonic lethality, incomplete penetrance [MP:0011102](1|0) (1|0|0)

Superfamily

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Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
GroEL-intermediate domain like0Direct
Ribonuclease PH domain 2-like0Direct
ARM repeat0.0000732Direct
SMAD MH1 domain0.001235Inherited
GroEL apical domain-like0.003669Inherited
DNA clamp0.003669Inherited
HCP-like0.004017Inherited
ADC-like0.0126Inherited
dsRNA-binding domain-like0.01633Inherited
Subtilisin-like0.03291Inherited
BRCT domain0.2443Inherited
Cullin homology domain0.4149Inherited
Zinc beta-ribbon0.4972Inherited
p53-like transcription factors0.7225Inherited
Nucleic acid-binding proteins0.7225Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Family

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Family

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SCOP term FDR (all) Annotation (direct or inherited)
Chromo barrel domain0Direct
Ribonuclease PH domain 2-like0Direct
Ribonuclease PH domain 1-like0Direct
Fumble-like0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
DNA ligase0Direct
Retinoblastoma tumor suppressor domains0Direct
RecA protein-like (ATPase-domain)0.00005462Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0001652Direct
SMAD domain0.0007241Direct
SMAD MH1 domain0.0007241Direct
SCF ubiquitin ligase complex WHB domain0.002277Inherited
Armadillo repeat0.006369Inherited
Proprotein convertase P-domain0.008283Inherited
Prohormone convertase 1 pro-domain0.008283Inherited
DNA polymerase I0.008283Inherited
C5 cytosine-specific DNA methylase, DCM0.008482Inherited
Subtilases0.01337Inherited
Tandem AAA-ATPase domain0.03091Inherited
T-box0.1258Inherited
Extracellular domain of cell surface receptors0.235Inherited
Erythroid transcription factor GATA-10.2895Inherited
Histone lysine methyltransferases0.3491Inherited
Cullin homology domain0.3576Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.3977Inherited
Linker histone H1/H50.4397Inherited
N-acetyl transferase, NAT0.6919Inherited
Cell cycle transcription factor e2f-dp0.7569Inherited
Extended AAA-ATPase domain0.8051Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Supra-domain (Single|Duplex|Triple)

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Supra-domain (Single)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
GroEL-intermediate domain like0Direct
Ribonuclease PH domain 2-like0Direct
ARM repeat0.00003487Direct
SMAD MH1 domain0.0006787Direct
DNA clamp0.002144Inherited
GroEL apical domain-like0.002144Inherited
HCP-like0.002361Inherited
ADC-like0.008006Inherited
dsRNA-binding domain-like0.01057Inherited
Subtilisin-like0.02254Inherited
BRCT domain0.2048Inherited
Cullin homology domain0.3681Inherited
Zinc beta-ribbon0.4497Inherited
p53-like transcription factors0.683Inherited
Nucleic acid-binding proteins0.683Inherited
Acyl-CoA N-acyltransferases (Nat)0.7499Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Duplex) in N- to C-terminal order

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.002144Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.002361Inherited
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.00784Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.01803Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.01803Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.02442Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02537Inherited

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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    Supra-domain (Triple) in N- to C-terminal order

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.00784Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.01803Inherited

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

    Distribution on sTOL

    Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this MP term
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    Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this MP term
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