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Worm Phenotype (WP): early embryonic lethal 

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term
(+ for parents, - for children)
WP term [WP ID] <#Children> #Domains
(Superfamily|Family)
#Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <5>
+ + + + 4:   development variant [WBPhenotype:0000518] <4>(511|586) (511|253|70)
+ + + 3:   organism development variant [WBPhenotype:0000531] <10>(505|584) (505|253|70)
+ + 2:   embryonic development variant [WBPhenotype:0000749] <21>(453|542) (453|238|67)
+ + 2:   lethal [WBPhenotype:0000062] <5>(502|582) (502|253|70)
+ 1:   embryonic lethal [WBPhenotype:0000050] <7>(451|541) (451|238|67)
0:   early embryonic lethal [WBPhenotype:0001100] <24>(41|39) (42|14|3)
- 1:   aster defective early emb [WBPhenotype:0001110] <3>(0|0) (0|0|0)
- 1:   cytokinesis defective early emb [WBPhenotype:0001078] <3>(5|8) (5|0|0)
- 1:   cell position defective early emb [WBPhenotype:0001118] <2>(1|0) (1|0|0)
- 1:   cytoplasmic appearance defective early emb [WBPhenotype:0000769] <2>(6|6) (6|2|0)
- 1:   egg integrity defective early emb [WBPhenotype:0001178] <2>(2|2) (3|1|0)
- 1:   embryonic morphology defective early emb [WBPhenotype:0001135] <2>(0|0) (0|0|0)
- 1:   other abnormality early emb [WBPhenotype:0001007] <2>(11|6) (11|2|1)
- 1:   polar body defective early emb [WBPhenotype:0001147] <2>(2|2) (2|1|0)
- 1:   pronuclear nuclear appearance defective early emb [WBPhenotype:0001034] <2>(7|10) (8|4|0)
- 1:   pseudocleavage defective early emb [WBPhenotype:0001167] <2>(0|0) (0|0|0)
- 1:   spindle defective early emb [WBPhenotype:0000759] <2>(7|11) (7|4|0)
- 1:   cell cell contacts defective early emb [WBPhenotype:0001117] <1>(2|1) (2|0|0)
- 1:   cell cycle defective early emb [WBPhenotype:0001114] <1>(2|2) (2|0|0)
- 1:   embryonic developmental delay early emb [WBPhenotype:0001185] <1>(0|0) (0|0|0)
- 1:   meiosis defective early emb [WBPhenotype:0001041] <1>(3|3) (3|0|0)
- 1:   Aba ABp division axis defective early emb [WBPhenotype:0001134](1|1) (1|1|0)
- 1:   asymmetric cell division defective early emb [WBPhenotype:0000748](0|0) (0|0|0)
- 1:   centrosome attachment defective early emb [WBPhenotype:0000771](0|0) (0|0|0)
- 1:   chromosome segregation variant karyomeres early emb [WBPhenotype:0001077](1|1) (1|1|0)
- 1:   cortical dynamics defective early emb [WBPhenotype:0001044](0|0) (0|0|0)
- 1:   egg size defective early emb [WBPhenotype:0000044](0|0) (0|0|0)
- 1:   integrity of membranous organelles defective early emb [WBPhenotype:0000767](0|0) (0|0|0)
- 1:   interphase entry defective early emb [WBPhenotype:0001043](0|0) (0|0|0)
- 1:   one cell arrest early emb [WBPhenotype:0000040](2|3) (2|0|0)

Superfamily

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Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
Histone-fold0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Skp1 dimerisation domain-like4.442e-16Direct
ARM repeat0.0000000000003562Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000000000001022Direct
Nucleic acid-binding proteins0.0000000001385Direct
GroEL-intermediate domain like0.0000000001641Direct
GroEL equatorial domain-like0.0000000001641Direct
GroEL apical domain-like0.000000001518Direct
Zn-binding ribosomal proteins0.00000003191Direct
Class II aaRS and biotin synthetases0.00000007174Direct
Translation proteins SH3-like domain0.0000008205Direct
Tubulin C-terminal domain-like0.00000214Direct
Cyclin-like0.000005022Direct
S15/NS1 RNA-binding domain0.000005917Direct
Prefoldin0.00001017Direct
"Winged helix" DNA-binding domain0.00001104Direct
Tubulin nucleotide-binding domain-like0.0000155Direct
Sm-like ribonucleoproteins0.00004508Direct
TPR-like0.00004541Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.00007851Direct
Cdc48 domain 2-like0.00007851Direct
ADC-like0.00007851Direct
Activating enzymes of the ubiquitin-like proteins0.0002468Direct
Class II aaRS ABD-related0.0002468Direct
WD40 repeat-like0.000314Direct
CAD & PB1 domains0.0003483Direct
L30e-like0.0005058Direct
Translation proteins0.0006407Direct
Translational machinery components0.000942Direct
Smc hinge domain0.000942Direct
Calponin-homology domain, CH-domain0.001864Inherited
Nucleotidylyl transferase0.005556Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01298Inherited
Invertebrate chitin-binding proteins0.01788Inherited
DNA/RNA polymerases0.03065Inherited
POZ domain0.03304Inherited
GTPase activation domain, GAP0.03455Inherited
UBC-like0.1731Inherited
BAR/IMD domain-like0.206Inherited
Multidrug efflux transporter AcrB transmembrane domain0.301Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Family

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Family

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SCOP term FDR (all) Annotation (direct or inherited)
Proteasome subunits0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Nucleosome core histones0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Anticodon-binding domain of Class II aaRS0Direct
a tRNA synthase domain0Direct
Skp1 dimerisation domain-like0.000000000000002504Direct
Extended AAA-ATPase domain0.00000000001377Direct
Group II chaperonin (CCT, TRIC), apical domain0.000000000801Direct
Armadillo repeat0.000000003877Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.000000105Direct
Cyclin0.000000105Direct
BTB/POZ domain0.000002652Direct
Motor proteins0.000004745Direct
Prefoldin0.000007143Direct
Tubulin, C-terminal domain0.000009225Direct
Ubiquitin activating enzymes (UBA)0.00001248Direct
Pumilio repeat0.00002256Direct
Tubulin, GTPase domain0.00005427Direct
Cdc48 domain 2-like0.0001353Direct
Cdc48 N-terminal domain-like0.0001353Direct
G proteins0.0001818Direct
Translational machinery components0.0005038Direct
L30e/L7ae ribosomal proteins0.0005974Direct
DEP domain0.0005974Direct
Smc hinge domain0.0005974Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0009578Direct
Cold shock DNA-binding domain-like0.000998Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.001112Inherited
Actin/HSP700.001466Inherited
WD40-repeat0.001879Inherited
DNA polymerase I0.003379Inherited
Calponin-homology domain, CH-domain0.005453Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01509Inherited
BCR-homology GTPase activation domain (BH-domain)0.06265Inherited
PDZ domain0.09269Inherited
UBC-related0.3009Inherited
Multidrug efflux transporter AcrB transmembrane domain0.35Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Supra-domain (Single|Duplex|Triple)

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Supra-domain (Single)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
P-loop containing nucleoside triphosphate hydrolases0Direct
Histone-fold0Direct
Skp1 dimerisation domain-like3.463e-16Direct
ARM repeat0.0000000000002789Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0000000000008016Direct
Nucleic acid-binding proteins0.0000000001093Direct
GroEL-intermediate domain like0.0000000001295Direct
GroEL equatorial domain-like0.0000000001295Direct
GroEL apical domain-like0.000000001202Direct
Zn-binding ribosomal proteins0.00000002542Direct
Class II aaRS and biotin synthetases0.00000005727Direct
Translation proteins SH3-like domain0.0000006598Direct
Tubulin C-terminal domain-like0.000001727Direct
Cyclin-like0.00000406Direct
S15/NS1 RNA-binding domain0.000004783Direct
Prefoldin0.000008227Direct
"Winged helix" DNA-binding domain0.000008938Direct
Tubulin nucleotide-binding domain-like0.00001256Direct
Sm-like ribonucleoproteins0.00003665Direct
TPR-like0.00003693Direct
ADC-like0.00006395Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.00006395Direct
Cdc48 domain 2-like0.00006395Direct
Class II aaRS ABD-related0.0002021Direct
Activating enzymes of the ubiquitin-like proteins0.0002021Direct
WD40 repeat-like0.0002575Direct
CAD & PB1 domains0.0002859Direct
L30e-like0.0004166Direct
Translation proteins0.0005288Direct
Smc hinge domain0.0007796Direct
Translational machinery components0.0007796Direct
Calponin-homology domain, CH-domain0.001556Inherited
Nucleotidylyl transferase0.004705Inherited
Actin-like ATPase domain0.007718Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01114Inherited
Invertebrate chitin-binding proteins0.01546Inherited
DNA/RNA polymerases0.02677Inherited
POZ domain0.02889Inherited
GTPase activation domain, GAP0.03025Inherited
UBC-like0.1584Inherited
BAR/IMD domain-like0.1897Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2812Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Duplex) in N- to C-terminal order

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 6.921e-16Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.0000000001295Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.0000000001295Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.000003428Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.00001256Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00001256Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.00006395Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.0002792Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.0007796Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.003046Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1427Inherited

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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    Supra-domain (Triple) in N- to C-terminal order

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.0000000001295Direct

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

    Distribution on sTOL

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