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Worm Phenotype (WP): early embryonic lethal 

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

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WP term [WP ID] <#Children> #Domains
(Superfamily|Family)
#Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <5>
+ + + + 4:   development variant [WBPhenotype:0000518] <4>(506|580) (506|253|70)
+ + + 3:   organism development variant [WBPhenotype:0000531] <10>(500|578) (500|253|70)
+ + 2:   embryonic development variant [WBPhenotype:0000749] <21>(448|537) (448|238|67)
+ + 2:   lethal [WBPhenotype:0000062] <5>(497|576) (497|253|70)
+ 1:   embryonic lethal [WBPhenotype:0000050] <7>(446|536) (446|238|67)
0:   early embryonic lethal [WBPhenotype:0001100] <24>(40|38) (41|14|3)
- 1:   aster defective early emb [WBPhenotype:0001110] <3>(0|0) (0|0|0)
- 1:   cytokinesis defective early emb [WBPhenotype:0001078] <3>(4|7) (5|0|0)
- 1:   cell position defective early emb [WBPhenotype:0001118] <2>(1|0) (1|0|0)
- 1:   cytoplasmic appearance defective early emb [WBPhenotype:0000769] <2>(6|6) (6|2|0)
- 1:   egg integrity defective early emb [WBPhenotype:0001178] <2>(2|2) (3|1|0)
- 1:   embryonic morphology defective early emb [WBPhenotype:0001135] <2>(0|0) (0|0|0)
- 1:   other abnormality early emb [WBPhenotype:0001007] <2>(11|6) (11|2|1)
- 1:   polar body defective early emb [WBPhenotype:0001147] <2>(2|2) (2|1|0)
- 1:   pronuclear nuclear appearance defective early emb [WBPhenotype:0001034] <2>(7|10) (8|4|0)
- 1:   pseudocleavage defective early emb [WBPhenotype:0001167] <2>(0|0) (0|0|0)
- 1:   spindle defective early emb [WBPhenotype:0000759] <2>(7|11) (7|4|0)
- 1:   cell cell contacts defective early emb [WBPhenotype:0001117] <1>(2|1) (2|0|0)
- 1:   cell cycle defective early emb [WBPhenotype:0001114] <1>(2|2) (2|0|0)
- 1:   embryonic developmental delay early emb [WBPhenotype:0001185] <1>(0|0) (0|0|0)
- 1:   meiosis defective early emb [WBPhenotype:0001041] <1>(3|3) (3|0|0)
- 1:   Aba ABp division axis defective early emb [WBPhenotype:0001134](1|1) (1|1|0)
- 1:   asymmetric cell division defective early emb [WBPhenotype:0000748](0|0) (0|0|0)
- 1:   centrosome attachment defective early emb [WBPhenotype:0000771](0|0) (0|0|0)
- 1:   chromosome segregation variant karyomeres early emb [WBPhenotype:0001077](1|1) (1|1|0)
- 1:   cortical dynamics defective early emb [WBPhenotype:0001044](0|0) (0|0|0)
- 1:   egg size defective early emb [WBPhenotype:0000044](0|0) (0|0|0)
- 1:   integrity of membranous organelles defective early emb [WBPhenotype:0000767](0|0) (0|0|0)
- 1:   interphase entry defective early emb [WBPhenotype:0001043](0|0) (0|0|0)
- 1:   one cell arrest early emb [WBPhenotype:0000040](2|3) (2|0|0)

Superfamily

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Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
Histone-fold0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Skp1 dimerisation domain-like4.457e-16Direct
ARM repeat0.0000000000003749Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00000000000105Direct
Nucleic acid-binding proteins0.000000000143Direct
GroEL equatorial domain-like0.0000000001667Direct
GroEL-intermediate domain like0.0000000001667Direct
GroEL apical domain-like0.000000001542Direct
Zn-binding ribosomal proteins0.00000003233Direct
Class II aaRS and biotin synthetases0.00000007302Direct
Translation proteins SH3-like domain0.0000008319Direct
Tubulin C-terminal domain-like0.00000217Direct
Cyclin-like0.0000051Direct
S15/NS1 RNA-binding domain0.000005969Direct
"Winged helix" DNA-binding domain0.000006757Direct
Prefoldin0.00001027Direct
Tubulin nucleotide-binding domain-like0.00001568Direct
TPR-like0.00003949Direct
Sm-like ribonucleoproteins0.00004564Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.00007905Direct
Cdc48 domain 2-like0.00007905Direct
ADC-like0.00007905Direct
Activating enzymes of the ubiquitin-like proteins0.0002489Direct
Class II aaRS ABD-related0.0002489Direct
WD40 repeat-like0.0003216Direct
CAD & PB1 domains0.0003511Direct
L30e-like0.0005096Direct
Translation proteins0.0006476Direct
Translational machinery components0.0009475Direct
Smc hinge domain0.0009475Direct
Calponin-homology domain, CH-domain0.001882Inherited
Nucleotidylyl transferase0.005598Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01304Inherited
Invertebrate chitin-binding proteins0.01799Inherited
DNA/RNA polymerases0.0308Inherited
POZ domain0.03536Inherited
GTPase activation domain, GAP0.08673Inherited
UBC-like0.1741Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3025Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Family

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Family

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SCOP term FDR (all) Annotation (direct or inherited)
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
a tRNA synthase domain0Direct
Nucleosome core histones0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
Anticodon-binding domain of Class II aaRS0Direct
Proteasome subunits0Direct
Skp1 dimerisation domain-like0.000000000000002511Direct
Extended AAA-ATPase domain0.0000000000138Direct
Group II chaperonin (CCT, TRIC), apical domain0.0000000008034Direct
Armadillo repeat0.00000000389Direct
Cyclin0.0000001053Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.0000001053Direct
BTB/POZ domain0.000003454Direct
Motor proteins0.000004758Direct
Prefoldin0.000007156Direct
Tubulin, C-terminal domain0.000009241Direct
Ubiquitin activating enzymes (UBA)0.00001251Direct
Pumilio repeat0.00002259Direct
Tubulin, GTPase domain0.00005433Direct
Cdc48 domain 2-like0.0001355Direct
Cdc48 N-terminal domain-like0.0001355Direct
G proteins0.0001821Direct
Translational machinery components0.0005047Direct
Smc hinge domain0.0005984Direct
DEP domain0.0005984Direct
L30e/L7ae ribosomal proteins0.0005984Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0009592Direct
Cold shock DNA-binding domain-like0.001Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.001113Inherited
Actin/HSP700.001468Inherited
WD40-repeat0.001886Inherited
DNA polymerase I0.003382Inherited
Calponin-homology domain, CH-domain0.005453Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0151Inherited
PDZ domain0.09279Inherited
UBC-related0.3008Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3501Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Supra-domain (Single|Duplex|Triple)

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Supra-domain (Single)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Histone-fold0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Skp1 dimerisation domain-like3.468e-16Direct
ARM repeat0.0000000000002931Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0000000000008216Direct
Nucleic acid-binding proteins0.0000000001127Direct
GroEL-intermediate domain like0.0000000001314Direct
GroEL equatorial domain-like0.0000000001314Direct
GroEL apical domain-like0.000000001219Direct
Zn-binding ribosomal proteins0.0000000257Direct
Class II aaRS and biotin synthetases0.00000005819Direct
Translation proteins SH3-like domain0.0000006682Direct
Tubulin C-terminal domain-like0.00000175Direct
Cyclin-like0.000004121Direct
S15/NS1 RNA-binding domain0.000004822Direct
"Winged helix" DNA-binding domain0.000005462Direct
Prefoldin0.000008305Direct
Tubulin nucleotide-binding domain-like0.00001271Direct
TPR-like0.00003207Direct
Sm-like ribonucleoproteins0.00003708Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.00006436Direct
Cdc48 domain 2-like0.00006436Direct
ADC-like0.00006436Direct
Class II aaRS ABD-related0.0002037Direct
Activating enzymes of the ubiquitin-like proteins0.0002037Direct
WD40 repeat-like0.0002636Direct
CAD & PB1 domains0.000288Direct
L30e-like0.0004197Direct
Translation proteins0.0005343Direct
Translational machinery components0.0007841Direct
Smc hinge domain0.0007841Direct
Calponin-homology domain, CH-domain0.001571Inherited
Nucleotidylyl transferase0.004742Inherited
Actin-like ATPase domain0.007787Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0112Inherited
Invertebrate chitin-binding proteins0.01555Inherited
DNA/RNA polymerases0.02691Inherited
POZ domain0.03097Inherited
GTPase activation domain, GAP0.07759Inherited
UBC-like0.1592Inherited
Multidrug efflux transporter AcrB transmembrane domain0.2825Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Duplex) in N- to C-terminal order

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 6.931e-16Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.0000000001314Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.0000000001314Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.000003468Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.00001271Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00001271Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.00006436Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.0002822Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.0007841Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.003074Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1435Inherited

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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    Supra-domain (Triple) in N- to C-terminal order

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.0000000001314Direct

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

    Distribution on sTOL

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