dcGO Enrichment: Identifying functions and other higher-order knowledge enriched within a list of input domains
For a list of input domains (e.g., a list of unusual domains found in a genome as compared to another genome) and the target ontologies (e.g., GO), the dcGO Enrichment uses domain-centric annotations and conducts enrichment analysis to identify the ontological terms enriched.
Analysis via hyperlinks (without submission form)
- Enrichment analysis is based on the hypergeometric distribution, followed by FDR-based assessment of the statistical significance of term enrichments.
- The dcGO Enrichment takes all annotatable domains (with respects to ontology) as the test background.
- The user can sumbit a list of domains containing single group (one entry per line) or multiple groups (1st column for group id; 2nd for SCOP domain id).
- Both of SCOP domains and PFAM domains are supported:
- When using SCOP domains, the domain id can be either SCOP unique identifiers (sunid), or SCOP concise classification strings (sccs), or mixture of them.
- When using PFAM domains, only Gene Ontology (GO) is supported.
where 'SCOP_sf ' indicates the SCOP superfamilies only, 'SCOP_fa' for the SCOP families only, 'SCOP_both' for the mixture of SCOP superfamilies and families, and 'pfam' for the PFAM families.
- e.g., performing enrichment analysis for a list of SCOP domains '46689,47266,55550,56854,109604':
- e.g., performing enrichment analysis for a list of PFAM domains 'PF05110,PF01833,PF01614,PF04082,PF00651':