dcGO - A comprehensive domain-centric ontology resource for post-genomic research on functions, phenotypes, diseases and more   
  
  

PFAM Hierarchy

Search PFAM hierarchy:
    Using accession (e.g., "PF00170" or "CL0018") or descrption (e.g., "bZIP transcription factor" or "bZIP-like leucine zipper")
    When searching against a descrption, it is better to specify clan or pfam (e.g., "PF:bZIP transcription factor" or "CL:bZIP-like leucine zipper").
    Notes: PF for pfam, and CL for clan

Root: PFAM Hierarchy with two levels (i.e., clan and family)

All clans in alphabetic order (A to Z Index)

A

ClanDescription [Accession] <#Members>
Prefixed with A   Alpha/Beta hydrolase fold [CL0028] <58>
  Actin-like ATPase Superfamily [CL0108] <24>
  APC superfamily [CL0062] <19>
  ATP-grasp superfamily [CL0179] <18>
  Amidohydrolase superfamily [CL0034] <11>
  ACT-like domain [CL0070] <10>
  ATP synthase F0 subunit [CL0255] <9>
  ADP-ribosylation Superfamily [CL0084] <8>
  Alkaline phosphatase-like [CL0088] <8>
  ABC-2-transporter-like clan [CL0181] <7>
  Ankyrin repeat superfamily [CL0465] <6>
  Acid phosphatase/Vanadium-dependent haloperoxidase [CL0525] <5>
  Aha1/BPI domain-like superfamily [CL0648] <5>
  Arrestin_N-like [CL0135] <5>
  AsmA-like OmpF regulator protein superfamily [CL0401] <5>
  Aminoacid dehydrogenase-like, N-terminal domain superfamily [CL0603] <4>
  Aspartate chemoreceptor, signal-transduction ligand-binding [CL0457] <4>
  ABC transporter membrane domain clan [CL0241] <3>
  ACP-like superfamily [CL0314] <3>
  AIG2/ChaC-like superfamily [CL0278] <3>
  ALDC superfamily [CL0615] <3>
  ANL superfamily [CL0378] <3>
  AOC barrel-like superfamily [CL0650] <3>
  AbrB/MraZ DNA-binding domain [CL0132] <3>
  Acyl-CoA dehydrogenase, C-terminal domain-like [CL0087] <3>
  Acylphosphatase/BLUF domain-like superfamily [CL0622] <3>
  Acyltransferase clan [CL0228] <3>
  Antitoxin of Type IV toxin-antitoxin, Abi system [CL0578] <3>
  all-alpha NTP pyrophosphohydrolase superfamily [CL0231] <3>
  ALDH-like superfamily [CL0099] <2>
  AMP-binding enzyme C-terminal domain superfamily [CL0531] <2>
  AT14A-like [CL0133] <2>
  Acetoacetate decarboxylase-like [CL0403] <2>
  Acetyl-decarboxylase like superfamily [CL0332] <2>
  Actin depolymerizing Factor [CL0092] <2>
  Acyl-coenzyme A oxidase/dehydrogenase N-terminal [CL0544] <2>
  Adenylate cyclase associated (CAP) C terminal like [CL0391] <2>
  AhpD-like superfamily [CL0423] <2>
  Amino acid biosynthesis and glycosomal dehydrogenase [CL0139] <2>
  Archaeo-eukaryotic primase [CL0243] <2>
  Arginase/deacetylase superfamily [CL0302] <2>
  Aspartate/glutamate racemase superfamily [CL0399] <2>
  ATPase domain of HSP90, DNA topoisomerase II and histidine kinase [CL0565] <1>
  Antigen MPT63/MPB63 (immunoprotective extracellular [CL0524] <1>

C

ClanDescription [Accession] <#Members>
Prefixed with C   Common phosphate binding-site TIM barrel superfamily [CL0036] <49>
  Cupin fold [CL0029] <47>
  Classical C2H2 and C2HC zinc fingers [CL0361] <30>
  Concanavalin-like lectin/glucanase superfamily [CL0004] <30>
  Cache-like domain [CL0165] <17>
  C2 superfamily [CL0154] <14>
  Class-I Glutamine amidotransferase superfamily [CL0014] <11>
  CPA/AT transporter superfamily [CL0064] <10>
  Calycin superfamily [CL0116] <10>
  Cytidine deaminase-like (CDA) superfamily [CL0109] <10>
  Cystine-knot cytokine superfamily [CL0079] <9>
  ClpP/Crotonase superfamily [CL0127] <8>
  Coiled-coil helix coiled-coil helix superfamily [CL0351] <8>
  Cyclin-like superfamily [CL0065] <8>
  Class II aminoacyl-tRNA and Biotin synthetases [CL0040] <7>
  Cytochrome c superfamily [CL0318] <7>
  C-type lectin-like superfamily [CL0056] <6>
  CYTH-like phosphatase superfamily [CL0273] <6>
  Calcineurin-like phosphoesterase superfamily [CL0163] <6>
  CoA-dependent acyltransferase superfamily [CL0149] <6>
  CheY-like superfamily [CL0304] <5>
  Cyclophilin-like superfamily [CL0475] <5>
  CCCH-zinc finger [CL0537] <4>
  Calponin homology domain [CL0188] <4>
  Carbohydrate binding domain superfamily [CL0203] <4>
  Chelatase Superfamily [CL0043] <4>
  Clathrin (AP) and COPI appendage platform subdomain [CL0545] <4>
  Copper resistance protein D [CL0430] <4>
  Creatinase/prolidase N-terminal domain superfamily [CL0356] <4>
  Cdc48 domain 2-like [CL0402] <3>
  Chemosensory 7tm receptor superfamily [CL0176] <3>
  Chorismate lyase/UTRA superfamily [CL0122] <3>
  Class II aaRS Anticodon-binding domain-like [CL0458] <3>
  Cobalamin-independent synthase [CL0160] <3>
  Copper amine oxidase, domains 1 and 2 [CL0047] <3>
  Cystatin-like superfamily [CL0121] <3>
  C1q and TNF superfamily [CL0100] <2>
  CCT like-motif [CL0281] <2>
  CI-2 family of serine protease inhibitors [CL0367] <2>
  CRAL-TRIO domain superfamily [CL0512] <2>
  CRISPR-associated (Cas) Repair Associated Mysterious Proteins [CL0362] <2>
  CTP transferase-like superfamily [CL0234] <2>
  CUB clan [CL0164] <2>
  Cell growth inhibitor/plasmid maintenance toxic component superfamily [CL0624] <2>
  Chalcone isomerase-like superfamily [CL0560] <2>
  Chaperone J-domain superfamily [CL0392] <2>
  CheC-like superfamily [CL0355] <2>
  Cholesterol-dependent cytolysin superfamily [CL0293] <2>
  Complex1_LYR-like superfamily [CL0491] <2>
  Cysteine-rich secretory proteins [CL0659] <2>
  Cytochrome oxidase biogenesis family [CL0376] <2>
  CST, telomere maintenance, complex subunit CTC1 [CL0586] <1>
  Carbohydrate binding domain 14/19 clan [CL0155] <1>
  Carbohydrate-binding superfamily [CL0535] <1>
  CheY-binding domain of CheA superfamily [CL0634] <1>
  Cobalamin adenosyltransferase-like superfamily [CL0601] <1>
  Colipase-like superfamily [CL0621] <1>

D

ClanDescription [Accession] <#Members>
Prefixed with D   Drug/Metabolite transporter superfamily [CL0184] <17>
  Dimeric alpha/beta barrel superfamily [CL0032] <16>
  DHS-like NAD/FAD-binding domain [CL0085] <8>
  DNA clamp superfamily [CL0060] <8>
  DSRM-like clan [CL0196] <7>
  DinB-like superfamily [CL0310] <7>
  DoxD-like [CL0131] <6>
  DNA/RNA ligase superfamily [CL0078] <5>
  Death Domain Superfamily [CL0041] <5>
  DAP epimerase superfamily [CL0288] <4>
  DNA breaking-rejoining enzyme superfamily [CL0382] <4>
  Defensin/myotoxin-like superfamily [CL0075] <4>
  Double Psi beta barrel glucanase [CL0199] <4>
  DALR superfamily [CL0258] <3>
  DNA-A N-terminal domain-like superfamily [CL0494] <3>
  Di-sulfide bond pairrings [CL0482] <3>
  DsrEFH-like superfamily [CL0394] <3>
  DExH-box splicing factor binding site [CL0449] <2>
  DNA methylase specificity domain [CL0477] <2>
  DNA polymerase B like [CL0194] <2>
  DNA-binding pseudo-barrel domain [CL0405] <2>
  DNase I-like [CL0530] <2>
  DUF1214-like [CL0528] <2>
  DUF362-like superfamily [CL0471] <2>
  DUF436/YokD-like superfamily [CL0627] <2>
  Dehydroquinate synthase-like superfamily [CL0224] <2>
  Di-copper centre-containing domain [CL0205] <2>
  Dihydrofolate reductase-like [CL0387] <2>
  DmpA/ArgJ-like superfamily [CL0635] <2>
  Duff-binding like superfamily [CL0195] <2>
  DNA primase large subunit like [CL0242] <1>
  DUF1304/DUF3784 clan [CL0447] <1>
  dUTPase like superfamily [CL0153] <1>

F

ClanDescription [Accession] <#Members>
Prefixed with F   FAD/NAD(P)-binding Rossmann fold Superfamily [CL0063] <167>
  Family A G protein-coupled receptor-like superfamily [CL0192] <32>
  4Fe-4S ferredoxins [CL0344] <23>
  Ferritin-like Superfamily [CL0044] <17>
  FYVE/PHD zinc finger superfamily [CL0390] <10>
  FKBP-like superfamily [CL0487] <7>
  FMN-binding split barrel superfamily [CL0336] <7>
  Fusaric acid resistance protein-like superfamily [CL0307] <7>
  FAD-linked oxidase C-terminal domain superfamily [CL0277] <6>
  Flavoprotein [CL0042] <6>
  2Fe-2S iron-sulfur cluster binding domain [CL0486] <5>
  F-box-like domain [CL0271] <4>
  FMN-dependent nitroreductase-like [CL0529] <4>
  Formate/glycerate dehydrogenase catalytic domain-like superfamily [CL0325] <4>
  Frizzled cysteine-rich domain-related superfamily [CL0644] <4>
  FAD/NAD-linked reductase C-terminal domain superfamily [CL0608] <3>
  Ferredoxin / Ferric reductase-like NAD binding [CL0091] <3>
  Flagellar motor switch family [CL0436] <3>
  Flp pilus-biogenesis Tad-like superfamily [CL0496] <3>
  Fumarate reductase respiratory complex transmembrane subunits [CL0335] <3>
  F-box associated [CL0162] <2>
  FAD-linked oxidoreductase [CL0086] <2>
  FERM middle domain superfamily [CL0632] <2>
  FF domain [CL0584] <2>
  Fibrinogen C-terminal domain-like [CL0422] <2>
  Folate binding domain [CL0289] <2>
  Frag1 like [CL0412] <2>
  FucI/AraA C-terminal domain-like [50443] [CL0393] <2>
  Fungal specific transcription factor domain [CL0507] <2>
  F-type and N-type ATPase, I/AtpR subunit [CL0478] <1>
  Families 57/38 glycoside transferase middle domain superfamily [CL0599] <1>
  Fatty acid responsive transcription factor FadR, C-terminal domain [CL0388] <1>
  Fimbriae A and Mfa superfamily [CL0450] <1>
  FixH-like [CL0488] <1>
  FtsL-like superfamily [CL0225] <1>
  Fumarylacetoacetate hydrolase, C-terminal domain, superfamily [CL0377] <1>

J

ClanDescription [Accession] <#Members>
Prefixed with J   JAB-like superfamily [CL0366] <5>

P

ClanDescription [Accession] <#Members>
Prefixed with P   P-loop containing nucleoside triphosphate hydrolase superfamily [CL0023] <175>
  PD-(D/E)XK nuclease superfamily [CL0236] <47>
  PH domain-like superfamily [CL0266] <47>
  Peptidase clan MA [CL0126] <45>
  Peptidase clan CA [CL0125] <34>
  Protein kinase superfamily [CL0016] <25>
  Periplasmic binding protein clan [CL0177] <23>
  PIN domain superfamily [CL0280] <14>
  Phosphatase superfamily [CL0031] <14>
  6-phosphogluconate dehydrogenase C-terminal-like superfamily [CL0106] <12>
  PAS domain clan [CL0183] <12>
  PLP dependent aminotransferase superfamily [CL0061] <12>
  Pectate lyase-like beta helix [CL0268] <12>
  Peptidase clan AA [CL0129] <12>
  Peptidase clan MH/MC/MF [CL0035] <11>
  PUA/ASCH superfamily [CL0178] <10>
  Periplasmic binding protein like [CL0144] <9>
  Peptidase clan CD [CL0093] <8>
  Pyruvate kinase-like TIM barrel superfamily [CL0151] <8>
  Phospholipase D superfamily [CL0479] <7>
  Pseudouridine synthase superfamily [CL0649] <7>
  PDZ domain-like peptide-binding superfamily [CL0466] <6>
  Plasmid toxin-antitoxin system [CL0136] <6>
  Probable substrate-binding preceding ATP-grasp domain [CL0483] <6>
  PFL-like glycyl radical enzyme superfamily [CL0339] <5>
  POTRA domain superfamily [CL0191] <5>
  POZ domain superfamily [CL0033] <5>
  PapD-like superfamily,immunoglobulin-like beta sandwich [CL0556] <5>
  Pelota - RNA ribose binding superfamily [CL0101] <5>
  Peptidase MD [CL0170] <5>
  Peptidase clan PA [CL0124] <5>
  post-AAA+ oligomerization domain-like superfamily [CL0604] <5>
  PAN-like [CL0168] <4>
  PC4-like superfamily [CL0609] <4>
  PHM/PNGase F superfamily [CL0612] <4>
  PLC-like phosphodiesterases [CL0384] <4>
  PRPP synthetase-associated protein 1 [CL0533] <4>
  Patatin/FabD/lysophospholipase-like superfamily [CL0323] <4>
  Phage tail tube proteins superfamily [CL0569] <4>
  Pilus subunit [CL0327] <4>
  Profilin-like superfamily [CL0431] <4>
  Protease propeptides/inhibitors [CL0570] <4>
  Protein kinase C, C1 domain [CL0006] <4>
  Purine and uridine phosphorylase superfamily [CL0408] <4>
  PFK-like superfamily [CL0240] <3>
  PP2C-like superfamily [CL0238] <3>
  Pentapeptide repeat [CL0505] <3>
  PepSY domain-like superfamily [CL0320] <3>
  Peptidase clan AD [CL0130] <3>
  Phage tail beta-barrel superfamily [CL0504] <3>
  Phospholipase A2 superfamily [CL0629] <3>
  Plexin fold superfamily [CL0630] <3>
  Prefoldin [CL0200] <3>
  PA14 superfamily [CL0301] <2>
  PCMH-like FAD binding [CL0077] <2>
  PEP carboxykinase-like superfamily [CL0374] <2>
  PLAT domain like superfamily [CL0321] <2>
  PRC-barrel like superfamily [CL0350] <2>
  ParB-like superfamily [CL0248] <2>
  Peptidase Clan ML [CL0095] <2>
  Peptidase clan SF [CL0299] <2>
  Peptidase clan SH [CL0201] <2>
  Peptidyl-tRNA hydrolase II superfamily [CL0305] <2>
  Peroxisome-like domain [CL0484] <2>
  Phage coat superfamily [CL0373] <2>
  Phage minor tail protein L clan [CL0249] <2>
  Phage tail assembly chaperone [CL0567] <2>
  PhoU-like superfamily [CL0297] <2>
  Phospholipase C/P1 nuclease superfamily [CL0368] <2>
  Phosphotransferase/anion transport protein superfamily [CL0340] <2>
  Positive stranded ssRNA viruses coat protein [CL0055] <2>
  Post-HMGL domain-like superfamily [CL0597] <2>
  PspA/ESCRT-III [CL0235] <2>
  PAZ domain superfamily [CL0638] <1>
  PGBD superfamily [CL0244] <1>
  PRD domain superfamily [CL0166] <1>
  PepSY_TM-like [CL0490] <1>
  Peptidase clan U [CL0472] <1>
  Phage fibre superfamily [CL0606] <1>
  Phage virion morphogenesis superfamily [CL0348] <1>
  Phenylalanine- and lysidine-tRNA synthetase domain superfamily [CL0383] <1>
  Phosphotransferase system, EIIC superfamily [CL0493] <1>
  Pyroglutamate aminopeptidase superfamily [CL0379] <1>

S

ClanDescription [Accession] <#Members>
Prefixed with S   Six-hairpin glycosidase superfamily [CL0059] <25>
  Src homology-3 domain [CL0010] <10>
  SPOUT Methyltransferase Superfamily [CL0098] <8>
  SGNH hydrolase superfamily [CL0264] <7>
  SHS2 domain [CL0319] <7>
  Serine beta-lactamase-like superfamily [CL0013] <6>
  Sterile Alpha Motif (SAM) domain [CL0003] <6>
  Steroid oxidoreductase superfamily [CL0115] <6>
  SNARE-like superfamily [CL0212] <5>
  SCP-2 sterol transfer superfamily [CL0311] <4>
  SIS domain fold [CL0067] <4>
  SMAD/FHA domain superfamily [CL0357] <4>
  SUKH superfamily [CL0526] <4>
  Sialidase superfamily [CL0434] <4>
  Sm (Small RNA binding protein domain) [CL0527] <4>
  Starch-binding domain like superfamily [CL0576] <4>
  SufE/NifU superfamily [CL0233] <4>
  S4 domain superfamily [CL0492] <3>
  SNARE-fusion membrane complex superfamily [CL0445] <3>
  SPOC domain-like superfamily [CL0616] <3>
  SRCR-like [CL0550] <3>
  STAS domain superfamily [CL0502] <3>
  STIR superfamily [CL0173] <3>
  Sec10-like superfamily [CL0294] <3>
  Succinyl-CoA synthetase flavodoxin domain superfamily [CL0506] <3>
  S15/NS1 RNA-binding domain superfamily [CL0600] <2>
  SH2, phosphotyrosine-recognition domain superfamily [CL0541] <2>
  SPFH superfamily [CL0433] <2>
  SRP alu RNA binding heterodimer, SRP9/14 superfamily [CL0623] <2>
  Scorpion toxin-like knottin superfamily [CL0054] <2>
  Sea anemone toxin k like [CL0213] <2>
  Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor [CL0448] <2>
  Serum albumin superfamily [CL0282] <2>
  Shuttling between cyosol and Golgi, peripheral membrane family [CL0456] <2>
  Small molecule-binding and fam 9 carbohydrate-binding module [CL0559] <2>
  Superoxide reductase-like superfamily [CL0503] <2>
  SOCS-box like superfamily [CL0642] <1>
  Sec14-like superfamily of golgi trafficking [CL0521] <1>
  ssDNA viruses Nucleoplasmin-like/VP coat superfamily [CL0605] <1>

T

ClanDescription [Accession] <#Members>
Prefixed with T   Tetratrico peptide repeat superfamily [CL0020] <114>
  Tim barrel glycosyl hydrolase superfamily [CL0058] <42>
  Thioredoxin-like [CL0172] <40>
  Tudor domain 'Royal family' [CL0049] <18>
  Thiolase-like Superfamily [CL0046] <14>
  Transthyretin superfamily [CL0287] <14>
  TRASH superfamily [CL0175] <10>
  Transporter superfamily, four TM region [CL0375] <10>
  TetR protein, C-terminal domain-like [CL0174] <9>
  Thiamin diphosphate-binding superfamily [CL0254] <9>
  Transmembrane di-heme cytochrome superfamily [CL0328] <8>
  Tetrahydrobiopterin biosynthesis-like enzyme superfamily [CL0334] <7>
  Transcription elongation factor G C-terminal [CL0437] <7>
  Terpenoid synthases superfamily [CL0613] <6>
  Toprim domain [CL0413] <6>
  Translation proteins of Elongation Factors superfamily [CL0575] <6>
  TolB, N-terminal domain [CL0342] <5>
  TRAF domain-like superfamily [CL0389] <4>
  Tautomerase/MIF superfamily [CL0082] <4>
  Transketolase C-terminal domain-like superfamily [CL0591] <4>
  Tubby C-terminal domain-like [CL0395] <4>
  Tubulin nucleotide-binding domain-like, GTPase [CL0566] <4>
  Twin-Arginine Translocation Motif [CL0300] <4>
  TATA-binding protein like [CL0407] <3>
  TIMP-like superfamily [CL0353] <3>
  Tiki-like, or EreA-ChaN-like 2His 2Glu metallopreotease SF [CL0572] <3>
  Trafficking protein [CL0147] <3>
  Transmembrane protein families of the Anoctamin type [CL0416] <3>
  Trigger factor/SurA domain [CL0262] <3>
  TrkA C-terminal domain-like [CL0582] <3>
  Tropomyosin-like superfamily [CL0452] <3>
  Type III secretory system chaperone [CL0097] <3>
  tRNA-binding arm superfamily [CL0298] <3>
  TNF receptor-like superfamily [CL0607] <2>
  Tetraspannin-like [CL0347] <2>
  TolA/TonB C-terminal [CL0428] <2>
  Transcription elongation factor C-terminal nonapeptide repeat [CL0462] <2>
  Transcriptional repressor beta-barrel domain [CL0206] <2>
  Tubulin, FtsZ and Misato and their C-termini, [CL0442] <2>
  TusA-like superfamily [CL0397] <2>
  Type II intron maturase-like superfamily [CL0359] <2>
  Type III antifreeze and spore coat polysaccharide [CL0489] <2>
  Type III secretion system-derived superfamily, hook-related [CL0424] <2>
  Tellurits and antibiotic resistance superfamily [CL0414] <1>
  Translocation domain of colicin-like bacteriocins [CL0446] <1>
  Type III secretion system types a and b chaperone [CL0419] <1>
  tRNA-intron endonuclease catalytic domain-like N-term [CL0476] <1>

V

ClanDescription [Accession] <#Members>
Prefixed with V   Vps51 domain superfamily [CL0295] <16>
  von Willebrand factor type A [CL0128] <15>
  VOC superfamily [CL0104] <6>
  von Willebrand Factor like superfamily [CL0451] <4>
  Variant surface antigens [CL0656] <2>
  Viral Gag protein [CL0148] <2>

W

ClanDescription [Accession] <#Members>
Prefixed with W   WRKY-GCM1 superfamily [CL0274] <6>
  WXG100-A/WXG100-B dimer [CL0352] <3>
  WYL-like superfamily [CL0654] <1>

Z

ClanDescription [Accession] <#Members>
Prefixed with Z   Zinc beta-ribbon [CL0167] <52>

A full list of clans

ClanDescription [Accession] <#Members>
Prefixed with A   Alpha/Beta hydrolase fold [CL0028] <58>
  Actin-like ATPase Superfamily [CL0108] <24>
  APC superfamily [CL0062] <19>
  ATP-grasp superfamily [CL0179] <18>
  Amidohydrolase superfamily [CL0034] <11>
  ACT-like domain [CL0070] <10>
  ATP synthase F0 subunit [CL0255] <9>
  ADP-ribosylation Superfamily [CL0084] <8>
  Alkaline phosphatase-like [CL0088] <8>
  ABC-2-transporter-like clan [CL0181] <7>
  Ankyrin repeat superfamily [CL0465] <6>
  Acid phosphatase/Vanadium-dependent haloperoxidase [CL0525] <5>
  Aha1/BPI domain-like superfamily [CL0648] <5>
  Arrestin_N-like [CL0135] <5>
  AsmA-like OmpF regulator protein superfamily [CL0401] <5>
  Aminoacid dehydrogenase-like, N-terminal domain superfamily [CL0603] <4>
  Aspartate chemoreceptor, signal-transduction ligand-binding [CL0457] <4>
  ABC transporter membrane domain clan [CL0241] <3>
  ACP-like superfamily [CL0314] <3>
  AIG2/ChaC-like superfamily [CL0278] <3>
  ALDC superfamily [CL0615] <3>
  ANL superfamily [CL0378] <3>
  AOC barrel-like superfamily [CL0650] <3>
  AbrB/MraZ DNA-binding domain [CL0132] <3>
  Acyl-CoA dehydrogenase, C-terminal domain-like [CL0087] <3>
  Acylphosphatase/BLUF domain-like superfamily [CL0622] <3>
  Acyltransferase clan [CL0228] <3>
  Antitoxin of Type IV toxin-antitoxin, Abi system [CL0578] <3>
  all-alpha NTP pyrophosphohydrolase superfamily [CL0231] <3>
  ALDH-like superfamily [CL0099] <2>
  AMP-binding enzyme C-terminal domain superfamily [CL0531] <2>
  AT14A-like [CL0133] <2>
  Acetoacetate decarboxylase-like [CL0403] <2>
  Acetyl-decarboxylase like superfamily [CL0332] <2>
  Actin depolymerizing Factor [CL0092] <2>
  Acyl-coenzyme A oxidase/dehydrogenase N-terminal [CL0544] <2>
  Adenylate cyclase associated (CAP) C terminal like [CL0391] <2>
  AhpD-like superfamily [CL0423] <2>
  Amino acid biosynthesis and glycosomal dehydrogenase [CL0139] <2>
  Archaeo-eukaryotic primase [CL0243] <2>
  Arginase/deacetylase superfamily [CL0302] <2>
  Aspartate/glutamate racemase superfamily [CL0399] <2>
  ATPase domain of HSP90, DNA topoisomerase II and histidine kinase [CL0565] <1>
  Antigen MPT63/MPB63 (immunoprotective extracellular [CL0524] <1>
Prefixed with B   Beta propeller clan [CL0186] <55>
  Barrel sandwich hybrid superfamily [CL0105] <16>
  Bet V 1 like [CL0209] <13>
  Beta-trefoil superfamily [CL0066] <12>
  BRCT like [CL0459] <8>
  Beta-sandwich DNA-binding domain [CL0073] <8>
  Beta-tent fold [CL0080] <7>
  Bacterial adhesin superfamily [CL0204] <5>
  beta-N-acetylhexosaminidase-like domain [CL0546] <4>
  BIR-like domains [CL0417] <3>
  BPD transporter like [CL0404] <3>
  Bcl-2 inhibitors of programmed cell death [CL0551] <3>
  Beta fructosidase superfamily [CL0143] <3>
  bZIP-like leucine zipper [CL0018] <3>
  Bacterial immunoglobulin/albumin-binding domain superfamily [CL0598] <2>
  beta-strand roll of R-module, superfamily [CL0592] <2>
  B region of SasG biofilm-forming surface protein [CL0593] <1>
  Bacterial membrane GlpM-like group [CL0420] <1>
  Bacteriophage holin superfamily II [CL0563] <1>
Prefixed with C   Common phosphate binding-site TIM barrel superfamily [CL0036] <49>
  Cupin fold [CL0029] <47>
  Classical C2H2 and C2HC zinc fingers [CL0361] <30>
  Concanavalin-like lectin/glucanase superfamily [CL0004] <30>
  Cache-like domain [CL0165] <17>
  C2 superfamily [CL0154] <14>
  Class-I Glutamine amidotransferase superfamily [CL0014] <11>
  CPA/AT transporter superfamily [CL0064] <10>
  Calycin superfamily [CL0116] <10>
  Cytidine deaminase-like (CDA) superfamily [CL0109] <10>
  Cystine-knot cytokine superfamily [CL0079] <9>
  ClpP/Crotonase superfamily [CL0127] <8>
  Coiled-coil helix coiled-coil helix superfamily [CL0351] <8>
  Cyclin-like superfamily [CL0065] <8>
  Class II aminoacyl-tRNA and Biotin synthetases [CL0040] <7>
  Cytochrome c superfamily [CL0318] <7>
  C-type lectin-like superfamily [CL0056] <6>
  CYTH-like phosphatase superfamily [CL0273] <6>
  Calcineurin-like phosphoesterase superfamily [CL0163] <6>
  CoA-dependent acyltransferase superfamily [CL0149] <6>
  CheY-like superfamily [CL0304] <5>
  Cyclophilin-like superfamily [CL0475] <5>
  CCCH-zinc finger [CL0537] <4>
  Calponin homology domain [CL0188] <4>
  Carbohydrate binding domain superfamily [CL0203] <4>
  Chelatase Superfamily [CL0043] <4>
  Clathrin (AP) and COPI appendage platform subdomain [CL0545] <4>
  Copper resistance protein D [CL0430] <4>
  Creatinase/prolidase N-terminal domain superfamily [CL0356] <4>
  Cdc48 domain 2-like [CL0402] <3>
  Chemosensory 7tm receptor superfamily [CL0176] <3>
  Chorismate lyase/UTRA superfamily [CL0122] <3>
  Class II aaRS Anticodon-binding domain-like [CL0458] <3>
  Cobalamin-independent synthase [CL0160] <3>
  Copper amine oxidase, domains 1 and 2 [CL0047] <3>
  Cystatin-like superfamily [CL0121] <3>
  C1q and TNF superfamily [CL0100] <2>
  CCT like-motif [CL0281] <2>
  CI-2 family of serine protease inhibitors [CL0367] <2>
  CRAL-TRIO domain superfamily [CL0512] <2>
  CRISPR-associated (Cas) Repair Associated Mysterious Proteins [CL0362] <2>
  CTP transferase-like superfamily [CL0234] <2>
  CUB clan [CL0164] <2>
  Cell growth inhibitor/plasmid maintenance toxic component superfamily [CL0624] <2>
  Chalcone isomerase-like superfamily [CL0560] <2>
  Chaperone J-domain superfamily [CL0392] <2>
  CheC-like superfamily [CL0355] <2>
  Cholesterol-dependent cytolysin superfamily [CL0293] <2>
  Complex1_LYR-like superfamily [CL0491] <2>
  Cysteine-rich secretory proteins [CL0659] <2>
  Cytochrome oxidase biogenesis family [CL0376] <2>
  CST, telomere maintenance, complex subunit CTC1 [CL0586] <1>
  Carbohydrate binding domain 14/19 clan [CL0155] <1>
  Carbohydrate-binding superfamily [CL0535] <1>
  CheY-binding domain of CheA superfamily [CL0634] <1>
  Cobalamin adenosyltransferase-like superfamily [CL0601] <1>
  Colipase-like superfamily [CL0621] <1>
Prefixed with D   Drug/Metabolite transporter superfamily [CL0184] <17>
  Dimeric alpha/beta barrel superfamily [CL0032] <16>
  DHS-like NAD/FAD-binding domain [CL0085] <8>
  DNA clamp superfamily [CL0060] <8>
  DSRM-like clan [CL0196] <7>
  DinB-like superfamily [CL0310] <7>
  DoxD-like [CL0131] <6>
  DNA/RNA ligase superfamily [CL0078] <5>
  Death Domain Superfamily [CL0041] <5>
  DAP epimerase superfamily [CL0288] <4>
  DNA breaking-rejoining enzyme superfamily [CL0382] <4>
  Defensin/myotoxin-like superfamily [CL0075] <4>
  Double Psi beta barrel glucanase [CL0199] <4>
  DALR superfamily [CL0258] <3>
  DNA-A N-terminal domain-like superfamily [CL0494] <3>
  Di-sulfide bond pairrings [CL0482] <3>
  DsrEFH-like superfamily [CL0394] <3>
  DExH-box splicing factor binding site [CL0449] <2>
  DNA methylase specificity domain [CL0477] <2>
  DNA polymerase B like [CL0194] <2>
  DNA-binding pseudo-barrel domain [CL0405] <2>
  DNase I-like [CL0530] <2>
  DUF1214-like [CL0528] <2>
  DUF362-like superfamily [CL0471] <2>
  DUF436/YokD-like superfamily [CL0627] <2>
  Dehydroquinate synthase-like superfamily [CL0224] <2>
  Di-copper centre-containing domain [CL0205] <2>
  Dihydrofolate reductase-like [CL0387] <2>
  DmpA/ArgJ-like superfamily [CL0635] <2>
  Duff-binding like superfamily [CL0195] <2>
  DNA primase large subunit like [CL0242] <1>
  DUF1304/DUF3784 clan [CL0447] <1>
  dUTPase like superfamily [CL0153] <1>
Prefixed with E   EF-hand like superfamily [CL0220] <21>
  EGF superfamily [CL0001] <15>
  5'-3'-exonuclease C-terminal sub-region [CL0464] <3>
  EDD superfamily [CL0245] <3>
  ENTH/ANTH/VHS superfamily [CL0009] <3>
  Endosomal sorting complex assembly domain [CL0596] <3>
  Enolase N-terminal domain-like superfamily [CL0227] <3>
  EPT/RTPC-like superfamily [CL0290] <2>
  Enolase like TIM barrel [CL0256] <2>
  eIF4e-like superfamily [CL0625] <2>
  Electron transport accessory protein superfamily [CL0610] <1>
  Endonuclease V-like superfamily [CL0189] <1>
Prefixed with F   FAD/NAD(P)-binding Rossmann fold Superfamily [CL0063] <167>
  Family A G protein-coupled receptor-like superfamily [CL0192] <32>
  4Fe-4S ferredoxins [CL0344] <23>
  Ferritin-like Superfamily [CL0044] <17>
  FYVE/PHD zinc finger superfamily [CL0390] <10>
  FKBP-like superfamily [CL0487] <7>
  FMN-binding split barrel superfamily [CL0336] <7>
  Fusaric acid resistance protein-like superfamily [CL0307] <7>
  FAD-linked oxidase C-terminal domain superfamily [CL0277] <6>
  Flavoprotein [CL0042] <6>
  2Fe-2S iron-sulfur cluster binding domain [CL0486] <5>
  F-box-like domain [CL0271] <4>
  FMN-dependent nitroreductase-like [CL0529] <4>
  Formate/glycerate dehydrogenase catalytic domain-like superfamily [CL0325] <4>
  Frizzled cysteine-rich domain-related superfamily [CL0644] <4>
  FAD/NAD-linked reductase C-terminal domain superfamily [CL0608] <3>
  Ferredoxin / Ferric reductase-like NAD binding [CL0091] <3>
  Flagellar motor switch family [CL0436] <3>
  Flp pilus-biogenesis Tad-like superfamily [CL0496] <3>
  Fumarate reductase respiratory complex transmembrane subunits [CL0335] <3>
  F-box associated [CL0162] <2>
  FAD-linked oxidoreductase [CL0086] <2>
  FERM middle domain superfamily [CL0632] <2>
  FF domain [CL0584] <2>
  Fibrinogen C-terminal domain-like [CL0422] <2>
  Folate binding domain [CL0289] <2>
  Frag1 like [CL0412] <2>
  FucI/AraA C-terminal domain-like [50443] [CL0393] <2>
  Fungal specific transcription factor domain [CL0507] <2>
  F-type and N-type ATPase, I/AtpR subunit [CL0478] <1>
  Families 57/38 glycoside transferase middle domain superfamily [CL0599] <1>
  Fatty acid responsive transcription factor FadR, C-terminal domain [CL0388] <1>
  Fimbriae A and Mfa superfamily [CL0450] <1>
  FixH-like [CL0488] <1>
  FtsL-like superfamily [CL0225] <1>
  Fumarylacetoacetate hydrolase, C-terminal domain, superfamily [CL0377] <1>
Prefixed with G   Glycosyl transferase clan GT-A [CL0110] <42>
  Glycosyl transferase clan GT-B [CL0113] <32>
  Galactose-binding domain-like superfamily [CL0202] <31>
  Glycosyl transferase GT-C superfamily [CL0111] <14>
  GAF domain-like [CL0161] <12>
  Galactose Mutarotase-like superfamily [CL0103] <12>
  Glycosyl hydrolase domain superfamily [CL0369] <12>
  Golgi-transport [CL0145] <9>
  gamma-glutamylcysteine synthetase/glutamine synthetase clan [CL0286] <9>
  Glycine-zipper TM superfamily [CL0500] <8>
  GlnB-like superfamily [CL0089] <7>
  Glycoside hydrolase/deacetylase superfamily [CL0158] <7>
  GME superfamily [CL0197] <5>
  Glutathione S-transferase, C-terminal domain [CL0497] <5>
  Gx transporter superfamily [CL0315] <5>
  Globin-like [CL0090] <4>
  Growth factor receptor Cys-rich [CL0547] <4>
  GIY-YIG endonuclease superfamily [CL0418] <3>
  GTPase activation domain superfamily [CL0409] <3>
  GroES-like superfamily [CL0296] <3>
  Gamma-Crystallin-like superfamily [CL0333] <2>
  General secretion pathway protein M [CL0331] <2>
  GAD domain superfamily [CL0250] <1>
  GFP-like superfamily [CL0069] <1>
  Gamma-tubulin complex superfamily [CL0540] <1>
Prefixed with H   Helix-turn-helix clan [CL0123] <175>
  HUP - HIGH-signature proteins, UspA, and PP-ATPase. [CL0039] <27>
  HAD superfamily [CL0137] <21>
  4-helical cytokine superfamily [CL0053] <19>
  Histone superfamily [CL0012] <13>
  Helix-hairpin-helix superfamily [CL0198] <12>
  His-Me finger endonuclease superfamily [CL0263] <12>
  His Kinase A (phospho-acceptor) domain [CL0025] <10>
  HotDog superfamily [CL0050] <10>
  HD/PDEase superfamily [CL0237] <8>
  HMG-box like superfamily [CL0114] <7>
  HIT superfamily [CL0265] <6>
  Hedgehog/intein (Hint) superfamily [CL0363] <6>
  2H phosphoesterase superfamily [CL0247] <5>
  Homing endonuclease-like superfamily [CL0324] <5>
  Heme NO and oxygen binding like [CL0210] <4>
  Heme oxygenase-like superfamily [CL0230] <4>
  HSP20-like chaperone superfamily [CL0190] <3>
  Helix-two-turns-helix superfamily [CL0303] <3>
  Hexapeptide repeat superfamily [CL0536] <3>
  HRDC-like superfamily [CL0426] <2>
  Hect, E3 ligase catalytic domain [CL0552] <2>
  Heme-dependent peroxidases superfamily [CL0617] <2>
  Histidine phosphatase superfamily [CL0071] <2>
  Hyaluronate lyase-like catalytic, N-terminal domain [CL0372] <2>
  HAS-barrel superfamily [CL0275] <1>
  Heme iron utilization protein-like superfamily [CL0312] <1>
  His-hydrophobic-His tranposase Y1,Y2 superfamily [CL0481] <1>
  Holin superfamily III [CL0564] <1>
  Hydrophilin-like superfamily [CL0385] <1>
Prefixed with I   Ig-like fold superfamily (E-set) [CL0159] <71>
  Immunoglobulin superfamily [CL0011] <13>
  IT (Ion Transporter) superfamily [CL0182] <12>
  Isomerase,CoA transferase & Translation initiation factor Superfamily [CL0246] <11>
  Ion channel (VIC) superfamily [CL0030] <6>
  Isocitrate/Isopropylmalate dehydrogenase-like superfamily [CL0270] <5>
  Integral membrane protein / protease [CL0207] <3>
  inositol polyphosphate 1 phosphatase like superfamily [CL0171] <3>
  Indolic compounds 2,3-dioxygenase-like superfamily [CL0380] <2>
  Inhibitors of suppressors of apoptosis Bax/Bak [CL0453] <2>
  Insulin-like superfamily [CL0239] <2>
  IHF-like DNA-binding protein supewrfamily [CL0548] <1>
Prefixed with J   JAB-like superfamily [CL0366] <5>
Prefixed with K   K-Homology (KH) domain Superfamily [CL0007] <9>
  KOW domain [CL0107] <6>
  Keratin_associated superfamily [CL0520] <3>
  Kinase associated domain 1-like [CL0573] <3>
  Kazal like domain [CL0005] <2>
  Kix domain of CBP (creb binding protein) and MED13/15 [CL0589] <2>
  Kringle/FnII superfamily [CL0602] <2>
  30 kDa viral movement proteins superfamily [CL0571] <1>
  Kleisin superfamily [CL0157] <1>
Prefixed with L   LysE transporter superfamily [CL0292] <15>
  Lysozyme-like superfamily [CL0037] <12>
  Leucine Rich Repeat [CL0022] <11>
  LeuD/IlvD-like [CL0364] <9>
  LTR-copia-type polyprotein segment [CL0523] <6>
  LEM/SAP HeH motif [CL0306] <5>
  Late secretory pathway transport machinery [CL0330] <5>
  LuxS/MPP-like metallohydrolase [CL0094] <5>
  LolA/B superfamily [CL0048] <4>
  L27 domain superfamily [CL0614] <3>
  Lipid-binding Ig-like superfamily [CL0532] <3>
  LisH-like [CL0561] <3>
  LysM-like domain [CL0187] <3>
  LCCL-domain like [CL0513] <2>
  LTXXQ-like superfamily [CL0515] <2>
  LigB-like superfamily [CL0283] <2>
  Lipo-protein attachment motif superfamily [CL0421] <2>
  lambda integrase N-terminal domain [CL0469] <2>
  L,D-transpeptidase catalytic domain [CL0508] <1>
  LDH C-terminal domain-like superfamily [CL0341] <1>
  LEF-8 like region of RNA polymerase Rpb2 [CL0410] <1>
  Leech antihemostatic protein superfamily [CL0620] <1>
Prefixed with M   Major Facilitator Superfamily [CL0015] <19>
  Multicopper oxidase-like domain [CL0026] <12>
  MetJ/Arc repressor, antitoxin of TA systems superfamily [CL0057] <10>
  Multiheme cytochrome superfamily [CL0317] <8>
  Membrane and transport protein [CL0142] <7>
  Metallo-hydrolase/oxidoreductase superfamily [CL0381] <7>
  MviN, MATE-like superfamily [CL0222] <7>
  MBD-like DNA-binding domain [CL0081] <6>
  MHC antigen-recognition domain [CL0343] <5>
  Mannose 6-phosphate receptor [CL0226] <5>
  Membrane acyl transferase superfamily [CL0316] <5>
  MACRO domain superfamily [CL0223] <4>
  MoCo carrier protein-like superfamily [CL0349] <4>
  MtN3-like, vesicle-trafficking cargo-receptors [CL0141] <4>
  Mad2 superfamily [CL0651] <3>
  Maf/Ham1 superfamily [CL0269] <3>
  MAPK-interacting Drmip-like superfamily [CL0538] <2>
  MARVEL domain containing superfamily [CL0396] <2>
  MORN repeat [CL0251] <2>
  Malectin-like superfamily [CL0468] <2>
  Membrane-bound O-acyltransferase,MBOAT,superfamily [CL0517] <2>
  Metal-bound fold, usually iron, metallothionein superfamily [CL0461] <2>
  Mitochondrial membrane transporting or complex assembly [CL0455] <2>
  Mog1p/PsbP-like superfamily [CL0619] <2>
  MTH1187/YkoF-like superfamily [CL0360] <1>
  Mannoase-binding lectin superfamily [CL0568] <1>
  MurF and HprK N-domain-like superfamily [CL0365] <1>
Prefixed with N   N-acetyltransferase like [CL0257] <31>
  NTF2-like superfamily [CL0051] <20>
  Nucleotidyltransferase superfamily [CL0260] <20>
  NTN hydrolase superfamily [CL0052] <14>
  NUDIX superfamily [CL0261] <8>
  Nucleotidyltransferase substrate binding domain [CL0291] <5>
  N-(deoxy)ribosyltransferase-like superfamily [CL0498] <3>
  Nucleotide cyclase superfamily [CL0276] <3>
  N-terminal of fungal STAND proteins superfamily [CL0587] <2>
  N-terminal, cytoplasmic domain of anti-sigma factor superfamily [CL0645] <2>
  NifU C-terminal domain-like superfamily [CL0232] <2>
  Nitrogen permease regulator family [CL0435] <2>
  Nucleoporin FG repeat [CL0647] <2>
  Nucleoporin superfamily [CL0585] <2>
  NusG-like [CL0439] <2>
  NADH dehydrogenase I, subunit N [CL0425] <1>
  NfeD like [CL0252] <1>
  NusB-like superfamily [CL0633] <1>
Prefixed with O   OB fold [CL0021] <56>
  Outer membrane beta-barrel protein superfamily [CL0193] <36>
  Omega toxin-like [CL0083] <5>
  O-antigen assembly enzyme superfamily [CL0499] <3>
  OstA superfamily [CL0259] <2>
  Oxidoreductase C terminal like [CL0218] <1>
Prefixed with P   P-loop containing nucleoside triphosphate hydrolase superfamily [CL0023] <175>
  PD-(D/E)XK nuclease superfamily [CL0236] <47>
  PH domain-like superfamily [CL0266] <47>
  Peptidase clan MA [CL0126] <45>
  Peptidase clan CA [CL0125] <34>
  Protein kinase superfamily [CL0016] <25>
  Periplasmic binding protein clan [CL0177] <23>
  PIN domain superfamily [CL0280] <14>
  Phosphatase superfamily [CL0031] <14>
  6-phosphogluconate dehydrogenase C-terminal-like superfamily [CL0106] <12>
  PAS domain clan [CL0183] <12>
  PLP dependent aminotransferase superfamily [CL0061] <12>
  Pectate lyase-like beta helix [CL0268] <12>
  Peptidase clan AA [CL0129] <12>
  Peptidase clan MH/MC/MF [CL0035] <11>
  PUA/ASCH superfamily [CL0178] <10>
  Periplasmic binding protein like [CL0144] <9>
  Peptidase clan CD [CL0093] <8>
  Pyruvate kinase-like TIM barrel superfamily [CL0151] <8>
  Phospholipase D superfamily [CL0479] <7>
  Pseudouridine synthase superfamily [CL0649] <7>
  PDZ domain-like peptide-binding superfamily [CL0466] <6>
  Plasmid toxin-antitoxin system [CL0136] <6>
  Probable substrate-binding preceding ATP-grasp domain [CL0483] <6>
  PFL-like glycyl radical enzyme superfamily [CL0339] <5>
  POTRA domain superfamily [CL0191] <5>
  POZ domain superfamily [CL0033] <5>
  PapD-like superfamily,immunoglobulin-like beta sandwich [CL0556] <5>
  Pelota - RNA ribose binding superfamily [CL0101] <5>
  Peptidase MD [CL0170] <5>
  Peptidase clan PA [CL0124] <5>
  post-AAA+ oligomerization domain-like superfamily [CL0604] <5>
  PAN-like [CL0168] <4>
  PC4-like superfamily [CL0609] <4>
  PHM/PNGase F superfamily [CL0612] <4>
  PLC-like phosphodiesterases [CL0384] <4>
  PRPP synthetase-associated protein 1 [CL0533] <4>
  Patatin/FabD/lysophospholipase-like superfamily [CL0323] <4>
  Phage tail tube proteins superfamily [CL0569] <4>
  Pilus subunit [CL0327] <4>
  Profilin-like superfamily [CL0431] <4>
  Protease propeptides/inhibitors [CL0570] <4>
  Protein kinase C, C1 domain [CL0006] <4>
  Purine and uridine phosphorylase superfamily [CL0408] <4>
  PFK-like superfamily [CL0240] <3>
  PP2C-like superfamily [CL0238] <3>
  Pentapeptide repeat [CL0505] <3>
  PepSY domain-like superfamily [CL0320] <3>
  Peptidase clan AD [CL0130] <3>
  Phage tail beta-barrel superfamily [CL0504] <3>
  Phospholipase A2 superfamily [CL0629] <3>
  Plexin fold superfamily [CL0630] <3>
  Prefoldin [CL0200] <3>
  PA14 superfamily [CL0301] <2>
  PCMH-like FAD binding [CL0077] <2>
  PEP carboxykinase-like superfamily [CL0374] <2>
  PLAT domain like superfamily [CL0321] <2>
  PRC-barrel like superfamily [CL0350] <2>
  ParB-like superfamily [CL0248] <2>
  Peptidase Clan ML [CL0095] <2>
  Peptidase clan SF [CL0299] <2>
  Peptidase clan SH [CL0201] <2>
  Peptidyl-tRNA hydrolase II superfamily [CL0305] <2>
  Peroxisome-like domain [CL0484] <2>
  Phage coat superfamily [CL0373] <2>
  Phage minor tail protein L clan [CL0249] <2>
  Phage tail assembly chaperone [CL0567] <2>
  PhoU-like superfamily [CL0297] <2>
  Phospholipase C/P1 nuclease superfamily [CL0368] <2>
  Phosphotransferase/anion transport protein superfamily [CL0340] <2>
  Positive stranded ssRNA viruses coat protein [CL0055] <2>
  Post-HMGL domain-like superfamily [CL0597] <2>
  PspA/ESCRT-III [CL0235] <2>
  PAZ domain superfamily [CL0638] <1>
  PGBD superfamily [CL0244] <1>
  PRD domain superfamily [CL0166] <1>
  PepSY_TM-like [CL0490] <1>
  Peptidase clan U [CL0472] <1>
  Phage fibre superfamily [CL0606] <1>
  Phage virion morphogenesis superfamily [CL0348] <1>
  Phenylalanine- and lysidine-tRNA synthetase domain superfamily [CL0383] <1>
  Phosphotransferase system, EIIC superfamily [CL0493] <1>
  Pyroglutamate aminopeptidase superfamily [CL0379] <1>
Prefixed with R   Ribonuclease H-like superfamily [CL0219] <34>
  Ring-finger/U-box superfamily [CL0229] <32>
  RRM-like clan [CL0221] <21>
  Ribosomal protein S5 domain 2-like superfamily [CL0329] <14>
  Retrovirus zinc finger-like domains [CL0511] <7>
  RND permease superfamily [CL0322] <5>
  Rep-like domain [CL0169] <5>
  Riboflavin synthase/Ferredoxin reductase FAD binding domain [CL0076] <5>
  Ribokinase-like superfamily [CL0118] <4>
  Ribosomal S24e, L23 and L15e superfamily [CL0652] <4>
  Ribosomal protein S11/L18p superfamily [CL0267] <4>
  RNA dependent RNA polymerase [CL0027] <3>
  RNA-DNA binding Alba-like superfamily [CL0441] <3>
  Rubredoxin-like [CL0045] <3>
  RBP11-like subunits of RNA polymerase [CL0509] <2>
  RGS-like superfamily [CL0272] <2>
  RIIa-like fold [CL0068] <2>
  RNA/DNA-metabolising metallo-beta-lactamase motif [CL0398] <2>
  RNase III domain-like superfamily [CL0539] <2>
  Ras guanyl-nucleotide exchange factor activity N-term [CL0542] <2>
  Release factor superfamily [CL0337] <2>
  Ribosomal protein L29, L29p, superfamily [CL0346] <2>
  Ribosomal proteins L15 bacteria, L18e archaea [CL0588] <2>
  Rieske-like iron-sulphur domain [CL0516] <2>
  Rof/RNase P subunit-like superfamily [CL0639] <2>
Prefixed with S   Six-hairpin glycosidase superfamily [CL0059] <25>
  Src homology-3 domain [CL0010] <10>
  SPOUT Methyltransferase Superfamily [CL0098] <8>
  SGNH hydrolase superfamily [CL0264] <7>
  SHS2 domain [CL0319] <7>
  Serine beta-lactamase-like superfamily [CL0013] <6>
  Sterile Alpha Motif (SAM) domain [CL0003] <6>
  Steroid oxidoreductase superfamily [CL0115] <6>
  SNARE-like superfamily [CL0212] <5>
  SCP-2 sterol transfer superfamily [CL0311] <4>
  SIS domain fold [CL0067] <4>
  SMAD/FHA domain superfamily [CL0357] <4>
  SUKH superfamily [CL0526] <4>
  Sialidase superfamily [CL0434] <4>
  Sm (Small RNA binding protein domain) [CL0527] <4>
  Starch-binding domain like superfamily [CL0576] <4>
  SufE/NifU superfamily [CL0233] <4>
  S4 domain superfamily [CL0492] <3>
  SNARE-fusion membrane complex superfamily [CL0445] <3>
  SPOC domain-like superfamily [CL0616] <3>
  SRCR-like [CL0550] <3>
  STAS domain superfamily [CL0502] <3>
  STIR superfamily [CL0173] <3>
  Sec10-like superfamily [CL0294] <3>
  Succinyl-CoA synthetase flavodoxin domain superfamily [CL0506] <3>
  S15/NS1 RNA-binding domain superfamily [CL0600] <2>
  SH2, phosphotyrosine-recognition domain superfamily [CL0541] <2>
  SPFH superfamily [CL0433] <2>
  SRP alu RNA binding heterodimer, SRP9/14 superfamily [CL0623] <2>
  Scorpion toxin-like knottin superfamily [CL0054] <2>
  Sea anemone toxin k like [CL0213] <2>
  Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor [CL0448] <2>
  Serum albumin superfamily [CL0282] <2>
  Shuttling between cyosol and Golgi, peripheral membrane family [CL0456] <2>
  Small molecule-binding and fam 9 carbohydrate-binding module [CL0559] <2>
  Superoxide reductase-like superfamily [CL0503] <2>
  SOCS-box like superfamily [CL0642] <1>
  Sec14-like superfamily of golgi trafficking [CL0521] <1>
  ssDNA viruses Nucleoplasmin-like/VP coat superfamily [CL0605] <1>
Prefixed with T   Tetratrico peptide repeat superfamily [CL0020] <114>
  Tim barrel glycosyl hydrolase superfamily [CL0058] <42>
  Thioredoxin-like [CL0172] <40>
  Tudor domain 'Royal family' [CL0049] <18>
  Thiolase-like Superfamily [CL0046] <14>
  Transthyretin superfamily [CL0287] <14>
  TRASH superfamily [CL0175] <10>
  Transporter superfamily, four TM region [CL0375] <10>
  TetR protein, C-terminal domain-like [CL0174] <9>
  Thiamin diphosphate-binding superfamily [CL0254] <9>
  Transmembrane di-heme cytochrome superfamily [CL0328] <8>
  Tetrahydrobiopterin biosynthesis-like enzyme superfamily [CL0334] <7>
  Transcription elongation factor G C-terminal [CL0437] <7>
  Terpenoid synthases superfamily [CL0613] <6>
  Toprim domain [CL0413] <6>
  Translation proteins of Elongation Factors superfamily [CL0575] <6>
  TolB, N-terminal domain [CL0342] <5>
  TRAF domain-like superfamily [CL0389] <4>
  Tautomerase/MIF superfamily [CL0082] <4>
  Transketolase C-terminal domain-like superfamily [CL0591] <4>
  Tubby C-terminal domain-like [CL0395] <4>
  Tubulin nucleotide-binding domain-like, GTPase [CL0566] <4>
  Twin-Arginine Translocation Motif [CL0300] <4>
  TATA-binding protein like [CL0407] <3>
  TIMP-like superfamily [CL0353] <3>
  Tiki-like, or EreA-ChaN-like 2His 2Glu metallopreotease SF [CL0572] <3>
  Trafficking protein [CL0147] <3>
  Transmembrane protein families of the Anoctamin type [CL0416] <3>
  Trigger factor/SurA domain [CL0262] <3>
  TrkA C-terminal domain-like [CL0582] <3>
  Tropomyosin-like superfamily [CL0452] <3>
  Type III secretory system chaperone [CL0097] <3>
  tRNA-binding arm superfamily [CL0298] <3>
  TNF receptor-like superfamily [CL0607] <2>
  Tetraspannin-like [CL0347] <2>
  TolA/TonB C-terminal [CL0428] <2>
  Transcription elongation factor C-terminal nonapeptide repeat [CL0462] <2>
  Transcriptional repressor beta-barrel domain [CL0206] <2>
  Tubulin, FtsZ and Misato and their C-termini, [CL0442] <2>
  TusA-like superfamily [CL0397] <2>
  Type II intron maturase-like superfamily [CL0359] <2>
  Type III antifreeze and spore coat polysaccharide [CL0489] <2>
  Type III secretion system-derived superfamily, hook-related [CL0424] <2>
  Tellurits and antibiotic resistance superfamily [CL0414] <1>
  Translocation domain of colicin-like bacteriocins [CL0446] <1>
  Type III secretion system types a and b chaperone [CL0419] <1>
  tRNA-intron endonuclease catalytic domain-like N-term [CL0476] <1>
Prefixed with U   Ubiquitin superfamily [CL0072] <48>
  UBA superfamily [CL0214] <12>
  Ubiquitin conjugating enzyme like superfamily [CL0208] <6>
  uPAR/Ly6/CD59/snake toxin-receptor superfamily [CL0117] <4>
  Uncharacterised membrane protein superfamily (UMP1) [CL0470] <2>
  Uteroglobin-like superfamily [CL0370] <2>
  UcrQ-like [CL0429] <1>
Prefixed with V   Vps51 domain superfamily [CL0295] <16>
  von Willebrand factor type A [CL0128] <15>
  VOC superfamily [CL0104] <6>
  von Willebrand Factor like superfamily [CL0451] <4>
  Variant surface antigens [CL0656] <2>
  Viral Gag protein [CL0148] <2>
Prefixed with W   WRKY-GCM1 superfamily [CL0274] <6>
  WXG100-A/WXG100-B dimer [CL0352] <3>
  WYL-like superfamily [CL0654] <1>
Prefixed with Y   Yip1/YIF1-like [CL0112] <4>
  YqgF-like family [CL0580] <3>
  YbjQ-like superfamily [CL0522] <2>
  YjbJ-CsbD-like superfamily [CL0406] <2>
  YjgF-like superfamily [CL0534] <2>
  YqeY-like superfamily [CL0279] <2>
  YgaC/TfoX-N like superfamily [CL0631] <1>
  YqbG-like superfamily [CL0643] <1>
Prefixed with Z   Zinc beta-ribbon [CL0167] <52>