Domain combination pairs in Apis mellifera 38.2d

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

1607 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	354	52
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	294	84
Immunoglobulin	Immunoglobulin	226	96
EGF/Laminin	EGF/Laminin	109	87
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	97	9
Immunoglobulin	Fibronectin type III	94	55
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	83	29
L domain-like	L domain-like	80	42
Fibronectin type III	Fibronectin type III	77	46
EGF/Laminin	Growth factor receptor domain	72	66
TPR-like	TPR-like	69	18
Cadherin-like	Cadherin-like	66	41
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	65	11
Calcium ATPase, transmembrane domain M	HAD-like	65	11
Growth factor receptor domain	Growth factor receptor domain	64	55
Calcium ATPase, transduction domain A	HAD-like	64	10
RNA-binding domain, RBD	RNA-binding domain, RBD	63	18
ABC transporter transmembrane region	ABC transporter transmembrane region	60	7
Nicotinic receptor ligand binding domain-like	Neurotransmitter-gated ion-channel transmembrane pore	60	2
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	60	8
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	56	6
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	55	5
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	55	5
ARM repeat	ARM repeat	53	23
Glucocorticoid receptor-like (DNA-binding domain)	Nuclear receptor ligand-binding domain	52	6
Voltage-gated potassium channels	Voltage-gated potassium channels	50	10
DBL homology domain (DH-domain)	PH domain-like	49	30
TSP-1 type 1 repeat	TSP-1 type 1 repeat	46	28
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	44	17
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	43	11
E set domains	E set domains	42	17
Homeodomain-like	Homeodomain-like	42	14
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	41	4
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	40	3
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	39	28
EGF/Laminin	Concanavalin A-like lectins/glucanases	38	30
BAR/IMD domain-like	SH3-domain	38	8
(Trans)glycosidases	Chitinase insertion domain	38	10
Second domain of FERM	PH domain-like	38	24
EF-hand	EF-hand	37	17
Spectrin repeat	Spectrin repeat	36	24
MFS general substrate transporter	Kazal-type serine protease inhibitors	36	5
Actin-like ATPase domain	Actin-like ATPase domain	35	8
Periplasmic binding protein-like I	Periplasmic binding protein-like II	33	6
LDL receptor-like module	LDL receptor-like module	33	29
PH domain-like	PH domain-like	33	23
PDZ domain-like	P-loop containing nucleoside triphosphate hydrolases	32	13
PDZ domain-like	PDZ domain-like	32	16
Cyclin-like	Cyclin-like	31	6
ARM repeat	Protein kinase-like (PK-like)	30	12
SH3-domain	P-loop containing nucleoside triphosphate hydrolases	29	10
Ubiquitin-like	Ubiquitin-like	28	18
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	28	4
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	28	8
Invertebrate chitin-binding proteins	Invertebrate chitin-binding proteins	27	14
RNI-like	L domain-like	27	14
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	27	11
PDZ domain-like	SH3-domain	27	12
Glucocorticoid receptor-like (DNA-binding domain)	Homeodomain-like	27	8
Ubiquitin-like	PH domain-like	26	18
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	26	4
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	26	7
Spermadhesin, CUB domain	Spermadhesin, CUB domain	26	20
GroES-like	NAD(P)-binding Rossmann-fold domains	25	6
Translation proteins	EF-G C-terminal domain-like	25	6
Metalloproteases ("zincins"), catalytic domain	TSP-1 type 1 repeat	24	11
Ankyrin repeat	Ankyrin repeat	24	13
FYVE/PHD zinc finger	FYVE/PHD zinc finger	24	13
WW domain	WW domain	24	14
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	24	6
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	24	11
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	24	8
Subtilisin-like	Galactose-binding domain-like	23	6
WD40 repeat-like	WD40 repeat-like	23	7
POZ domain	Kelch motif	23	6
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	23	9
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	23	8
Chitinase insertion domain	Invertebrate chitin-binding proteins	23	8
(Trans)glycosidases	Invertebrate chitin-binding proteins	23	8
Ubiquitin-like	Second domain of FERM	22	14
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	22	2
Thioredoxin-like	GST C-terminal domain-like	22	2
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	21	3
HLH, helix-loop-helix DNA-binding domain	PYP-like sensor domain (PAS domain)	21	7
Terpenoid cyclases/Protein prenyltransferases	Alpha-macroglobulin receptor domain	21	5
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	21	7
EF-G C-terminal domain-like	EF-G C-terminal domain-like	21	4
SH3-domain	SH2 domain	21	7
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	20	4
SH3-domain	SH3-domain	20	11
Nucleotide cyclase	Nucleotide cyclase	20	3
HLH, helix-loop-helix DNA-binding domain	Orange domain-like	20	3
Cadherin-like	Concanavalin A-like lectins/glucanases	19	14
Voltage-gated potassium channels	cAMP-binding domain-like	19	5
C-type lectin-like	C-type lectin-like	19	1
RNI-like	F-box domain	19	4
Cupredoxins	Cupredoxins	19	6
Calponin-homology domain, CH-domain	Spectrin repeat	19	13
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	19	2
Sec7 domain	ARM repeat	19	6
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	19	2
SH2 domain	Protein kinase-like (PK-like)	19	6
ARM repeat	Formin homology 2 domain (FH2 domain)	19	4
Fibronectin type III	Protein kinase-like (PK-like)	19	10
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	19	6
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	19	6
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	19	6
Galactose-binding domain-like	Growth factor receptor domain	18	9
POZ domain	Voltage-gated potassium channels	18	3
LDL receptor-like module	Growth factor receptor domain	18	17
GroEL equatorial domain-like	GroEL apical domain-like	18	3
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	18	2
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	18	1
Metalloproteases ("zincins"), catalytic domain	Blood coagulation inhibitor (disintegrin)	18	2
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	18	5
FYVE/PHD zinc finger	Bromodomain	18	13
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	18	4
Growth factor receptor domain	Protein kinase-like (PK-like)	18	7
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	18	10
cAMP-binding domain-like	cAMP-binding domain-like	17	6
Protease propeptides/inhibitors	Zn-dependent exopeptidases	17	1
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	17	1
Voltage-gated potassium channels	Periplasmic binding protein-like II	17	5
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	17	7
YWTD domain	EGF/Laminin	17	14
DPY module	DPY module	17	17
LDL receptor-like module	EGF/Laminin	17	17
Sema domain	Plexin repeat	17	7
GroEL-intermediate domain like	GroEL apical domain-like	17	2
GroEL equatorial domain-like	GroEL-intermediate domain like	17	2
SH3-domain	PH domain-like	17	10
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	16	4
Concanavalin A-like lectins/glucanases	Growth factor receptor domain	16	16
Immunoglobulin	Protein kinase-like (PK-like)	16	13
E set domains	Alpha-macroglobulin receptor domain	16	1
GAF domain-like	HD-domain/PDEase-like	16	5
Calponin-homology domain, CH-domain	PH domain-like	16	8
Spectrin repeat	PH domain-like	16	10
YWTD domain	YWTD domain	16	12
YWTD domain	LDL receptor-like module	16	15
CoA-dependent acyltransferases	CoA-dependent acyltransferases	16	2
E set domains	Terpenoid cyclases/Protein prenyltransferases	16	1
L domain-like	Toll/Interleukin receptor TIR domain	15	12
Growth factor receptor domain	YWTD domain	15	14
ACT-like	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	15	2
SH2 domain	PH domain-like	15	6
Periplasmic binding protein-like I	Voltage-gated potassium channels	15	3
Spermadhesin, CUB domain	EGF/Laminin	15	9
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	15	5
EF-hand	PLC-like phosphodiesterases	14	7
PAZ domain	Ribonuclease H-like	14	4
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	14	3
Translation proteins	Ribosomal protein S5 domain 2-like	14	4
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	14	11
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	14	6
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	14	2
Thiolase-like	Thiolase-like	14	4
Protein kinase-like (PK-like)	Nucleotide cyclase	14	5
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	14	6
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	14	3
L domain-like	Immunoglobulin	14	9
PH domain-like	Protein kinase-like (PK-like)	14	6
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	14	4
TSP-1 type 1 repeat	Immunoglobulin	14	8
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	14	6
Ligand-binding domain in the NO signalling and Golgi transport	Nucleotide cyclase	13	1
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	13	7
L domain-like	Protein kinase-like (PK-like)	13	6
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex, superhelical domain	13	4
"Winged helix" DNA-binding domain	Periplasmic binding protein-like II	13	1
PreATP-grasp domain	Rudiment single hybrid motif	13	5
Myosin rod fragments	Myosin rod fragments	13	6
Cadherin-like	EGF/Laminin	13	8
DPY module	Growth factor receptor domain	13	13
Galactose-binding domain-like	Protein kinase-like (PK-like)	12	4
GAF domain-like	GAF domain-like	12	3
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	12	2
FnI-like domain	FnI-like domain	12	10
TSP-1 type 1 repeat	BPTI-like	12	7
PH domain-like	EF-hand	12	5
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	12	7
Cysteine-rich domain	Cysteine-rich domain	12	6
BAR/IMD domain-like	GTPase activation domain, GAP	12	5
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	12	6
Fibronectin type III	(Phosphotyrosine protein) phosphatases II	12	8
Thioredoxin-like	Thioredoxin-like	12	5
Growth factor receptor domain	Fibronectin type III	12	4
RING/U-box	B-box zinc-binding domain	12	6
SMAD MH1 domain	SMAD/FHA domain	12	2
Trypsin-like serine proteases	Trypsin-like serine proteases	12	3
PH domain-like	PLC-like phosphodiesterases	12	5
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	11	5
Tex N-terminal region-like	Ribonuclease H-like	11	4
RING/U-box	WD40 repeat-like	11	3
E set domains	GTPase activation domain, GAP	11	2
RING/U-box	RING/U-box	11	7
Cytochrome P450	Cytochrome P450	11	4
Ribonuclease H-like	Nucleic acid-binding proteins	11	4
Ribonuclease H-like	RuvA domain 2-like	11	4
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	11	2
Plexin repeat	E set domains	11	2
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	11	2
Plexin repeat	GTPase activation domain, GAP	11	2
SH3-domain	DBL homology domain (DH-domain)	11	7
Tex N-terminal region-like	Nucleic acid-binding proteins	11	4
Tudor/PWWP/MBT	Tudor/PWWP/MBT	11	8
L domain-like	Growth factor receptor domain	11	4
Protein kinase-like (PK-like)	P-loop containing nucleoside triphosphate hydrolases	11	4
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	11	1
Sema domain	GTPase activation domain, GAP	11	2
Immunoglobulin	(Phosphotyrosine protein) phosphatases II	11	7
Snake toxin-like	Protein kinase-like (PK-like)	11	3
Tex N-terminal region-like	RuvA domain 2-like	11	4
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	11	4
PH domain-like	(Phosphotyrosine protein) phosphatases II	11	7
Sema domain	E set domains	11	2
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	11	2
RuvA domain 2-like	Nucleic acid-binding proteins	11	4
LDL receptor-like module	Spermadhesin, CUB domain	11	10
Single hybrid motif	CoA-dependent acyltransferases	11	4
RuvA domain 2-like	RuvA domain 2-like	11	4
Protein kinase-like (PK-like)	Cysteine-rich domain	11	4
PreATP-grasp domain	Methylglyoxal synthase-like	10	3
WW domain	FF domain	10	4
Periplasmic binding protein-like I	Nucleotide cyclase	10	3
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	10	3
Ribonuclease H-like	DNA/RNA polymerases	10	3
FF domain	FF domain	10	4
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	10	3
PYP-like sensor domain (PAS domain)	Voltage-gated potassium channels	10	3
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	10	6
MFS general substrate transporter	MFS general substrate transporter	10	4
Periplasmic binding protein-like I	Protein kinase-like (PK-like)	10	3
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	10	3
SH2 domain	SH2 domain	10	6
SAM/Pointed domain	SAM/Pointed domain	10	4
Cap-Gly domain	Cap-Gly domain	10	4
C2 domain (Calcium/lipid-binding domain, CaLB)	C-terminal domain of PLC-beta	10	4
Complement control module/SCR domain	Complement control module/SCR domain	10	9
RING/U-box	Cysteine proteinases	10	4
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	10	3
lambda repressor-like DNA-binding domains	Homeodomain-like	10	4
PreATP-grasp domain	PreATP-grasp domain	10	3
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	10	3
Ubiquitin-like	Protein kinase-like (PK-like)	10	4
Cysteine proteinases	EF-hand	10	1
SH3-domain	Protein kinase-like (PK-like)	10	5
Calpain large subunit, middle domain (domain III)	EF-hand	10	1
Di-copper centre-containing domain	E set domains	10	5
SAM/Pointed domain	"Winged helix" DNA-binding domain	10	2
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	10	4
ARM repeat	Clathrin adaptor appendage domain	10	3
Chromo domain-like	Chromo domain-like	10	3
dsRNA-binding domain-like	dsRNA-binding domain-like	10	6
Cysteine-rich domain	PH domain-like	10	4
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	10	3
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	9	3
Glycosyl hydrolase domain	(Trans)glycosidases	9	4
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	9	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	9	3
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	9	1
Hemocyanin, N-terminal domain	E set domains	9	4
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	9	2
TPR-like	Chaperone J-domain	9	2
P-loop containing nucleoside triphosphate hydrolases	PH domain-like	9	6
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	9	5
Cullin homology domain	"Winged helix" DNA-binding domain	9	3
EF-hand	C-terminal domain of PLC-beta	9	3
PH domain-like	C-terminal domain of PLC-beta	9	3
PH domain-like	PDZ domain-like	9	5
Integrin domains	Integrin domains	9	5
PLC-like phosphodiesterases	C-terminal domain of PLC-beta	9	3
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	9	4
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	9	3
"Winged helix" DNA-binding domain	Chorismate lyase-like	9	1
Subtilisin-like	Growth factor receptor domain	9	4
Initiation factor IF2/eIF5b, domain 3	Translation proteins	9	2
FYVE/PHD zinc finger	Tudor/PWWP/MBT	9	6
PYP-like sensor domain (PAS domain)	cAMP-binding domain-like	9	2
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	9	4
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	9	4
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, dispensable insert domain	9	2
Resolvase-like	Homeodomain-like	9	1
DNA breaking-rejoining enzymes	Eukaryotic DNA topoisomerase I, dispensable insert domain	9	2
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	9	7
Hemocyanin, N-terminal domain	Di-copper centre-containing domain	9	4
SH3-domain	GTPase activation domain, GAP	9	4
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	9	2
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	9	2
TB module/8-cys domain	Growth factor receptor domain	8	8
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	8	3
Concanavalin A-like lectins/glucanases	IP3 receptor type 1 binding core, domain 2	8	3
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	8	3
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex; beta-sheet shell regions	8	3
MIR domain	EF-hand	8	3
Thiolase-like	FabD/lysophospholipase-like	8	2
EF-hand	RING/U-box	8	2
Thiolase-like	alpha/beta-Hydrolases	8	2
Aconitase iron-sulfur domain	LeuD/IlvD-like	8	2
WW domain	Hect, E3 ligase catalytic domain	8	5
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8	2
Thiolase-like	NAD(P)-binding Rossmann-fold domains	8	2
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	8	2
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	8	2
DBL homology domain (DH-domain)	Ras GEF	8	5
Probable ACP-binding domain of malonyl-CoA ACP transacylase	NAD(P)-binding Rossmann-fold domains	8	2
Transmembrane di-heme cytochromes	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8	1
Thiolase-like	GroES-like	8	2
Probable ACP-binding domain of malonyl-CoA ACP transacylase	ACP-like	8	2
PH domain-like	Ras GEF	8	5
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	8	3
Ubiquitin-like	Ras GEF	8	4
Zn-finger domain of Sec23/24	vWA-like	8	3
MIR domain	MIR domain	8	3
TB module/8-cys domain	TB module/8-cys domain	8	8
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	8	1
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	8	2
POZ domain	POZ domain	8	5
P-loop containing nucleoside triphosphate hydrolases	Myosin rod fragments	8	1
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	8	2
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	8	2
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	8	4
Calponin-homology domain, CH-domain	E set domains	8	6
BRCT domain	BRCT domain	8	7
GroES-like	alpha/beta-Hydrolases	8	2
TB module/8-cys domain	EGF/Laminin	8	8
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	8	2
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	8	6
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	8	3
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	8	4
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	8	2
PH domain-like	GTPase activation domain, GAP	8	7
Tropomyosin	Tropomyosin	8	7
cAMP-binding domain-like	Protein kinase-like (PK-like)	8	1
ACP-like	alpha/beta-Hydrolases	8	2
FabD/lysophospholipase-like	NAD(P)-binding Rossmann-fold domains	8	2
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	8	6
Ankyrin repeat	SAM/Pointed domain	8	3
GroES-like	ACP-like	8	2
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	8	2
alpha-catenin/vinculin-like	alpha-catenin/vinculin-like	8	6
NAD(P)-binding Rossmann-fold domains	ACP-like	8	2
WD40 repeat-like	TPR-like	8	5
beta-sandwich domain of Sec23/24	vWA-like	8	3
MIR domain	IP3 receptor type 1 binding core, domain 2	8	3
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	8	2
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	8	6
Concanavalin A-like lectins/glucanases	ARM repeat	8	3
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	8	3
beta-sandwich domain of Sec23/24	Zn-finger domain of Sec23/24	8	3
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8	2
HMA, heavy metal-associated domain	HAD-like	8	6
MIR domain	Concanavalin A-like lectins/glucanases	8	3
Concanavalin A-like lectins/glucanases	EF-hand	8	3
PHM/PNGase F	PHM/PNGase F	8	3
IP3 receptor type 1 binding core, domain 2	EF-hand	8	3
Probable ACP-binding domain of malonyl-CoA ACP transacylase	GroES-like	8	2
FabD/lysophospholipase-like	GroES-like	8	2
NAD(P)-binding Rossmann-fold domains	alpha/beta-Hydrolases	8	2
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	8	2
Integrin alpha N-terminal domain	Integrin domains	8	4
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	8	2
Probable ACP-binding domain of malonyl-CoA ACP transacylase	alpha/beta-Hydrolases	8	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	8	1
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	8	2
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	8	3
Thiolase-like	ACP-like	8	2
Kringle-like	Protein kinase-like (PK-like)	8	2
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	8	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	8	3
FabD/lysophospholipase-like	alpha/beta-Hydrolases	8	2
C2 domain (Calcium/lipid-binding domain, CaLB)	WW domain	8	5
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	8	2
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	8	2
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	8	3
PurM N-terminal domain-like	PurM C-terminal domain-like	8	4
ENTH/VHS domain	GAT-like domain	8	2
FabD/lysophospholipase-like	ACP-like	8	2
PH domain-like	ArfGap/RecO-like zinc finger	8	5
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	7	1
CCCH zinc finger	RING/U-box	7	3
Calponin-homology domain, CH-domain	SH3-domain	7	3
UBA-like	Ubiquitin-like	7	4
HR1 repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	7	5
(Trans)glycosidases	(Trans)glycosidases	7	6
Quinoprotein alcohol dehydrogenase-like	WD40 repeat-like	7	5
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	7	1
Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	7	3
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	7	2
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	7	1
HR1 repeat	HR1 repeat	7	5
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	7	3
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	7	5
P-loop containing nucleoside triphosphate hydrolases	Concanavalin A-like lectins/glucanases	7	5
Concanavalin A-like lectins/glucanases	RING/U-box	7	3
ADC-like	P-loop containing nucleoside triphosphate hydrolases	7	3
L domain-like	UBA-like	7	2
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	7	2
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	7	1
FYVE/PHD zinc finger	SET domain	7	5
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	7	1
Periplasmic binding protein-like II	Periplasmic binding protein-like II	7	1
(Trans)glycosidases	Galactose-binding domain-like	7	4
Galactose oxidase, central domain	POZ domain	7	6
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	7	2
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	7	2
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	7	3
BAR/IMD domain-like	PH domain-like	7	4
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	7	5
Actin depolymerizing proteins	Actin depolymerizing proteins	7	3
Glucocorticoid receptor-like (DNA-binding domain)	beta-beta-alpha zinc fingers	7	3
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	7	3
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	7	2
Acetyl-CoA synthetase-like	Acetyl-CoA synthetase-like	7	4
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	7	2
ADC-like	Cdc48 domain 2-like	7	3
C2 domain (Calcium/lipid-binding domain, CaLB)	Hect, E3 ligase catalytic domain	7	4
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	7	2
Nucleic acid-binding proteins	Nucleic acid-binding proteins	7	4
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	7	1
Chitinase insertion domain	Chitinase insertion domain	7	6
NTF2-like	UBA-like	7	2
Myosin S1 fragment, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	7	1
Galactose-binding domain-like	Fibronectin type III	7	3
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	7	1
HR1 repeat	Protein kinase-like (PK-like)	7	5
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	7	3
PDZ domain-like	Ubiquitin-like	7	4
Spermadhesin, CUB domain	Growth factor receptor domain	7	4
L domain-like	NTF2-like	7	2
vWA-like	Helical domain of Sec23/24	7	2
Kazal-type serine protease inhibitors	EF-hand	7	5
P-loop containing nucleoside triphosphate hydrolases	EF-hand	7	3
Sec63 N-terminal domain-like	E set domains	7	3
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	7	3
C2 domain (Calcium/lipid-binding domain, CaLB)	GTPase activation domain, GAP	7	6
DNA clamp	DNA clamp	7	1
LDL receptor-like module	Concanavalin A-like lectins/glucanases	6	6
GTPase activation domain, GAP	RGC domain-like	6	2
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	6	3
CCCH zinc finger	CCCH zinc finger	6	5
RING/U-box	Homeodomain-like	6	4
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	6	3
FYVE/PHD zinc finger	Clavaminate synthase-like	6	4
Family A G protein-coupled receptor-like	Family A G protein-coupled receptor-like	6	2
Class I glutamine amidotransferase-like	Glutathione synthetase ATP-binding domain-like	6	2
BAR/IMD domain-like	Ankyrin repeat	6	3
Ubiquitin-like	C2 domain (Calcium/lipid-binding domain, CaLB)	6	3
RuvA domain 2-like	SH2 domain	6	3
F-box domain	WD40 repeat-like	6	3
Phospholipase D/nuclease	Phospholipase D/nuclease	6	3
Glutathione synthetase ATP-binding domain-like	PurM N-terminal domain-like	6	2
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	6	2
Invertebrate chitin-binding proteins	LDL receptor-like module	6	4
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	6	2
Protease propeptides/inhibitors	Galactose-binding domain-like	6	1
UBA-like	RNA-binding domain, RBD	6	3
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	6	3
Rudiment single hybrid motif	PurM N-terminal domain-like	6	2
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	6	3
Enolase N-terminal domain-like	Enolase C-terminal domain-like	6	1
Spectrin repeat	EF-hand	6	4
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	6	3
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	6	4
SH2 domain	SOCS box-like	6	2
Surp module (SWAP domain)	Surp module (SWAP domain)	6	3
Metalloproteases ("zincins"), catalytic domain	Spermadhesin, CUB domain	6	4
vWA-like	EGF/Laminin	6	3
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	6	3
Tex N-terminal region-like	SH2 domain	6	3
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	6	2
TPR-like	RING/U-box	6	2
RNA-binding domain, RBD	SPOC domain-like	6	3
Tropomyosin	Myosin rod fragments	6	6
B-box zinc-binding domain	NHL repeat	6	3
Bromodomain	Tudor/PWWP/MBT	6	3
Galactose-binding domain-like	Concanavalin A-like lectins/glucanases	6	4
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	6	2
Rudiment single hybrid motif	Single hybrid motif	6	2
Ribonuclease H-like	SH2 domain	6	3
ArfGap/RecO-like zinc finger	Ankyrin repeat	6	3
PR-1-like	Crisp domain-like	6	2
(Trans)glycosidases	Six-hairpin glycosidases	6	1
Class I glutamine amidotransferase-like	PreATP-grasp domain	6	2
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	6	4
ARM repeat	Subdomain of clathrin and coatomer appendage domain	6	2
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	6	4
Cysteine-rich domain	Ubiquitin-like	6	3
Class I glutamine amidotransferase-like	Carbamoyl phosphate synthetase, large subunit connection domain	6	2
GAT-like domain	Clathrin adaptor appendage domain	6	1
PH domain-like	Ankyrin repeat	6	3
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	6	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Carbamoyl phosphate synthetase, large subunit connection domain	6	2
ENTH/VHS domain	Clathrin adaptor appendage domain	6	1
PUA domain-like	RING/U-box	6	5
Carbamoyl phosphate synthetase, small subunit N-terminal domain	PreATP-grasp domain	6	2
EF-hand	Ferredoxin reductase-like, C-terminal NADP-linked domain	6	3
EF-hand	Riboflavin synthase domain-like	6	3
Nucleotidylyl transferase	Alpha-L RNA-binding motif	6	1
BPTI-like	BPTI-like	6	6
Protease propeptides/inhibitors	Subtilisin-like	6	1
Rudiment single hybrid motif	PurM C-terminal domain-like	6	2
L domain-like	Family A G protein-coupled receptor-like	6	6
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	6	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Methylglyoxal synthase-like	6	2
PreATP-grasp domain	PurM C-terminal domain-like	6	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	6	2
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	6	3
Glutathione synthetase ATP-binding domain-like	PurM C-terminal domain-like	6	2
PUA domain-like	P-loop containing nucleoside triphosphate hydrolases	6	2
PreATP-grasp domain	PurM N-terminal domain-like	6	2
C2 domain (Calcium/lipid-binding domain, CaLB)	ARM repeat	6	2
Adenine nucleotide alpha hydrolases-like	YjgF-like	6	3
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	6	2
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	6	1
YjgF-like	YjgF-like	6	3
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	6	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Glutathione synthetase ATP-binding domain-like	6	2
PreATP-grasp domain	Single hybrid motif	6	2
EF-hand	Calponin-homology domain, CH-domain	6	3
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	6	2
CalX-like	CalX-like	6	1
Nucleic acid-binding proteins	SH2 domain	6	3
Glutathione synthetase ATP-binding domain-like	Metallo-dependent hydrolases	5	1
Calponin-homology domain, CH-domain	SH2 domain	5	1
Cullin repeat-like	Cullin homology domain	5	2
P-loop containing nucleoside triphosphate hydrolases	SMAD/FHA domain	5	4
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	5	1
PYP-like sensor domain (PAS domain)	HD-domain/PDEase-like	5	1
SRCR-like	Trypsin-like serine proteases	5	5
p53-like transcription factors	E set domains	5	3
EGF/Laminin	Integrin beta tail domain	5	2
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	5	3
Spectrin repeat	DBL homology domain (DH-domain)	5	3
Fibronectin type III	Concanavalin A-like lectins/glucanases	5	1
Complement control module/SCR domain	Growth factor receptor domain	5	5
BRK domain-like	P-loop containing nucleoside triphosphate hydrolases	5	1
Ankyrin repeat	P-loop containing nucleoside triphosphate hydrolases	5	4
Carbamoyl phosphate synthetase, large subunit connection domain	Aspartate/ornithine carbamoyltransferase	5	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	5	1
L domain-like	Fibronectin type III	5	1
Immunoglobulin	EGF/Laminin	5	5
RING/U-box	DUSP-like	5	1
GTPase activation domain, GAP	Bet v1-like	5	1
lambda repressor-like DNA-binding domains	LexA/Signal peptidase	5	1
PH domain-like	BEACH domain	5	3
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	5	1
Carbamoyl phosphate synthetase, large subunit connection domain	Metallo-dependent hydrolases	5	1
PX domain	Phospholipase D/nuclease	5	2
BRCT domain	DBL homology domain (DH-domain)	5	4
Complement control module/SCR domain	Galactose-binding domain-like	5	5
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	5	2
BRK domain-like	Bromodomain	5	1
Protein kinase-like (PK-like)	FAT domain of focal adhesion kinase	5	3
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	5	2
Methylglyoxal synthase-like	Composite domain of metallo-dependent hydrolases	5	1
Bromodomain	Bromodomain	5	3
Methylglyoxal synthase-like	Aspartate/ornithine carbamoyltransferase	5	1
Kelch motif	Kelch motif	5	2
TGS-like	ThrRS/AlaRS common domain	5	2
Immunoglobulin	Growth factor receptor domain	5	5
PH domain-like	WD40 repeat-like	5	2
Galactose-binding domain-like	Galactose-binding domain-like	5	5
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Composite domain of metallo-dependent hydrolases	5	1
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	5	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	5	3
Ankyrin repeat	POZ domain	5	3
PH domain-like	FAT domain of focal adhesion kinase	5	3
Class I glutamine amidotransferase-like	Aspartate/ornithine carbamoyltransferase	5	1
Second domain of FERM	FAT domain of focal adhesion kinase	5	3
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	5	2
P-loop containing nucleoside triphosphate hydrolases	Retrovirus zinc finger-like domains	5	2
P-loop containing nucleoside triphosphate hydrolases	Quinoprotein alcohol dehydrogenase-like	5	3
ARID-like	Clavaminate synthase-like	5	3
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	5	3
Notch domain	Ankyrin repeat	5	5
B-box zinc-binding domain	Fibronectin type III	5	1
TGS-like	Class II aaRS ABD-related	5	2
CRAL/TRIO domain	Spectrin repeat	5	3
RING/U-box	Fibronectin type III	5	1
PreATP-grasp domain	Composite domain of metallo-dependent hydrolases	5	1
FAS1 domain	FAS1 domain	5	3
Composite domain of metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	5	1
Methylglyoxal synthase-like	Metallo-dependent hydrolases	5	1
TGS-like	Class II aaRS and biotin synthetases	5	2
Notch domain	Notch domain	5	5
A DNA-binding domain in eukaryotic transcription factors	Leucine zipper domain	5	4
HIT/MYND zinc finger-like	TPR-like	5	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Metallo-dependent hydrolases	5	1
FYVE/PHD zinc finger	Chromo domain-like	5	1
CCHHC domain	Acyl-CoA N-acyltransferases (Nat)	5	2
Carbamoyl phosphate synthetase, large subunit connection domain	Composite domain of metallo-dependent hydrolases	5	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Chaperone J-domain	5	3
P-loop containing nucleoside triphosphate hydrolases	GTPase activation domain, GAP	5	2
Integrin domains	Integrin beta tail domain	5	2
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	5	2
EGF/Laminin	DPY module	5	5
CRAL/TRIO domain	PH domain-like	5	3
Bet v1-like	HAD-like	5	1
Glutathione synthetase ATP-binding domain-like	Composite domain of metallo-dependent hydrolases	5	1
Cysteine proteinases	DUSP-like	5	1
Growth factor receptor domain	Notch domain	5	5
EGF/Laminin	Notch domain	5	5
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	5	3
ThrRS/AlaRS common domain	Class II aaRS ABD-related	5	2
Kazal-type serine protease inhibitors	Kazal-type serine protease inhibitors	5	4
Growth factor receptor domain	Ankyrin repeat	5	5
Integrin domains	EGF/Laminin	5	2
Class I glutamine amidotransferase-like	Metallo-dependent hydrolases	5	1
CBS-domain pair	CBS-domain pair	5	1
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	5	3
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	5	2
PreATP-grasp domain	Aspartate/ornithine carbamoyltransferase	5	1
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	5	2
(Phosphotyrosine protein) phosphatases II	Chaperone J-domain	5	3
Second domain of FERM	Protein kinase-like (PK-like)	5	3
LDL receptor-like module	Immunoglobulin	5	5
CRAL/TRIO domain	DBL homology domain (DH-domain)	5	3
ARM repeat	WD40 repeat-like	5	3
vWA-like	Integrin beta tail domain	5	2
Protein kinase-like (PK-like)	PDZ domain-like	5	2
Metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	5	1
LDL receptor-like module	Trypsin-like serine proteases	5	5
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Aspartate/ornithine carbamoyltransferase	5	1
EGF/Laminin	Ankyrin repeat	5	5
PreATP-grasp domain	Metallo-dependent hydrolases	5	1
P-loop containing nucleoside triphosphate hydrolases	dsRNA-binding domain-like	5	3
vWA-like	Integrin domains	5	2
SNARE-like	SNARE fusion complex	5	2
EGF/Laminin	Calcium-dependent phosphotriesterase	5	1
Carboxypeptidase regulatory domain-like	Calcium-dependent phosphotriesterase	5	1
RING/U-box	TRAF domain-like	5	3
Calponin-homology domain, CH-domain	DBL homology domain (DH-domain)	5	1
Glutathione synthetase ATP-binding domain-like	Aspartate/ornithine carbamoyltransferase	5	1
ARM repeat	Hect, E3 ligase catalytic domain	5	2
SET domain	TPR-like	5	3
PH domain-like	Phospholipase D/nuclease	5	2
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	5	2
Sec7 domain	PH domain-like	5	2
Chaperone J-domain	Homeodomain-like	5	1
Zn-dependent exopeptidases	Zn-dependent exopeptidases	5	3
Tudor/PWWP/MBT	SAM/Pointed domain	5	3
EGF/Laminin	Carboxypeptidase regulatory domain-like	5	1
HIT/MYND zinc finger-like	SET domain	5	3
Cyclophilin-like	TPR-like	5	1
PX domain	PH domain-like	5	2
DBL homology domain (DH-domain)	SH2 domain	5	1
DUSP-like	DUSP-like	5	1
NAD(P)-binding Rossmann-fold domains	SCP-like	5	2
EF-hand	SH3-domain	5	4
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	cAMP-binding domain-like	5	2
B-box zinc-binding domain	Concanavalin A-like lectins/glucanases	5	1
Class I glutamine amidotransferase-like	Composite domain of metallo-dependent hydrolases	5	1
Spectrin repeat	SH3-domain	5	5
MgtE membrane domain-like	MgtE membrane domain-like	4	1
RNA-binding domain, RBD	NTF2-like	4	1
Protein kinase-like (PK-like)	(Phosphotyrosine protein) phosphatases II	4	2
PH domain-like	Ypt/Rab-GAP domain of gyp1p	4	3
S15/NS1 RNA-binding domain	C-terminal domain of ProRS	4	2
SAP domain	P-loop containing nucleoside triphosphate hydrolases	4	2
Formate/glycerate dehydrogenase catalytic domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	4	1
LDL receptor-like module	Mannose 6-phosphate receptor domain	4	2
Surp module (SWAP domain)	Ubiquitin-like	4	1
PreATP-grasp domain	post-HMGL domain-like	4	1
Glutathione synthetase ATP-binding domain-like	post-HMGL domain-like	4	1
RCC1/BLIP-II	Hect, E3 ligase catalytic domain	4	1
PGBD-like	Metalloproteases ("zincins"), catalytic domain	4	2
Ubiquitin-like	NAD kinase/diacylglycerol kinase-like	4	2
Concanavalin A-like lectins/glucanases	FnI-like domain	4	4
Elafin-like	Immunoglobulin	4	4
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	4	2
Ankyrin repeat	Mib/herc2 domain-like	4	2
PX domain	SH3-domain	4	3
Chaperone J-domain	beta-beta-alpha zinc fingers	4	1
Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	4	2
Rhodanese/Cell cycle control phosphatase	(Phosphotyrosine protein) phosphatases II	4	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	4	1
Complement control module/SCR domain	C-type lectin-like	4	4
Galactose oxidase, central domain	Kelch motif	4	3
"Winged helix" DNA-binding domain	E set domains	4	2
Protein kinase-like (PK-like)	SAM/Pointed domain	4	2
RNase III domain-like	RNase III domain-like	4	3
DBL homology domain (DH-domain)	C2 domain (Calcium/lipid-binding domain, CaLB)	4	2
GST C-terminal domain-like	Nucleotidylyl transferase	4	2
Second domain of FERM	Moesin tail domain	4	2
Histone-fold	DBL homology domain (DH-domain)	4	4
Thioredoxin-like	Six-hairpin glycosidases	4	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	4	2
Carboxypeptidase regulatory domain-like	Carboxypeptidase regulatory domain-like	4	2
RNA-binding domain, RBD	Ran binding protein zinc finger-like	4	1
Galactose-binding domain-like	EGF/Laminin	4	4
Cysteine proteinases	Transglutaminase, two C-terminal domains	4	3
Plexin repeat	vWA-like	4	2
PH domain-like	ARM repeat	4	2
FKBP-like	TPR-like	4	2
PAH2 domain	PAH2 domain	4	1
PUA domain-like	Ribosomal protein S5 domain 2-like	4	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	4	2
ARM repeat	P-loop containing nucleoside triphosphate hydrolases	4	1
Ubiquitin-like	RNA-binding domain, RBD	4	2
RNA-binding domain, RBD	L domain-like	4	1
post-HMGL domain-like	Single hybrid motif	4	1
(Phosphotyrosine protein) phosphatases II	Nucleic acid-binding proteins	4	1
Bromodomain	HIT/MYND zinc finger-like	4	2
Tudor/PWWP/MBT	HIT/MYND zinc finger-like	4	2
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	4	2
WD40 repeat-like	SNARE fusion complex	4	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	4	2
PH domain-like	Oxysterol-binding protein-like	4	3
FnI-like domain	Growth factor receptor domain	4	4
RNA-binding domain, RBD	PWI domain	4	1
Metalloproteases ("zincins"), catalytic domain	EGF/Laminin	4	2
Rudiment single hybrid motif	post-HMGL domain-like	4	1
DNA-binding domain	Bromodomain	4	3
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	4	1
RUN domain-like	RUN domain-like	4	1
Nucleotidylyl transferase	S15/NS1 RNA-binding domain	4	2
Protein kinase-like (PK-like)	Chaperone J-domain	4	2
GFP-like	Growth factor receptor domain	4	4
Invertebrate chitin-binding proteins	Glycoside hydrolase/deacetylase	4	2
TRAF domain-like	Cysteine proteinases	4	1
FYVE/PHD zinc finger	HIT/MYND zinc finger-like	4	2
PDZ domain-like	DBL homology domain (DH-domain)	4	3
Histone-fold	Ras GEF	4	4
Clc chloride channel	CBS-domain pair	4	1
RNA-binding domain, RBD	NAD kinase/diacylglycerol kinase-like	4	2
Metalloproteases ("zincins"), catalytic domain	Hemopexin-like domain	4	2
ARID-like	FYVE/PHD zinc finger	4	2
Calponin-homology domain, CH-domain	Calponin-homology domain, CH-domain	4	3
P-loop containing nucleoside triphosphate hydrolases	POZ domain	4	2
Ubiquitin-like	ARM repeat	4	1
Cyclophilin-like	RNA-binding domain, RBD	4	2
WW domain	PDZ domain-like	4	3
Aldolase	post-HMGL domain-like	4	1
alpha-helical ferredoxin	Nucleotide-binding domain	4	2
TAZ domain	Kix domain of CBP (creb binding protein)	4	4
LDL receptor-like module	Glycoside hydrolase/deacetylase	4	2
Starch-binding domain-like	Starch-binding domain-like	4	2
PH domain-like	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	4	3
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	4	3
GTPase activation domain, GAP	SH2 domain	4	2
RUN domain-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	4	1
BPTI-like	Immunoglobulin	4	4
Histone-fold	PH domain-like	4	4
BPTI-like	Elafin-like	4	4
RNase III domain-like	dsRNA-binding domain-like	4	3
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	4	2
Transglutaminase, two C-terminal domains	Transglutaminase, two C-terminal domains	4	3
GFP-like	YWTD domain	4	4
Regulator of G-protein signaling, RGS	Protein kinase-like (PK-like)	4	1
Ubiquitin-like	FAT domain of focal adhesion kinase	4	2
Regulator of G-protein signaling, RGS	PX domain	4	3
P-loop containing nucleoside triphosphate hydrolases	E set domains	4	2
L domain-like	P-loop containing nucleoside triphosphate hydrolases	4	4
TSP-1 type 1 repeat	Elafin-like	4	4
Cullin repeat-like	"Winged helix" DNA-binding domain	4	1
ClpS-like	"Winged helix" DNA-binding domain	4	1
Galactose-binding domain-like	C-type lectin-like	4	4
ClpP/crotonase	ClpP/crotonase	4	2
PH domain-like	Moesin tail domain	4	2
Cysteine-rich domain	RNA-binding domain, RBD	4	2
Aldolase	Single hybrid motif	4	1
PDZ domain-like	Glucocorticoid receptor-like (DNA-binding domain)	4	2
lambda repressor-like DNA-binding domains	Periplasmic binding protein-like I	4	1
HCP-like	HCP-like	4	3
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	4	3
FF domain	GTPase activation domain, GAP	4	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	4	2
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	4	1
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	4	1
Rudiment single hybrid motif	Aldolase	4	1
L27 domain	PDZ domain-like	4	3
GST C-terminal domain-like	S15/NS1 RNA-binding domain	4	2
Complement control module/SCR domain	EGF/Laminin	4	4
P-loop containing nucleoside triphosphate hydrolases	FF domain	4	1
SAP domain	Concanavalin A-like lectins/glucanases	4	2
Glutathione synthetase ATP-binding domain-like	Aldolase	4	1
NAD kinase/diacylglycerol kinase-like	Ankyrin repeat	4	2
(Phosphotyrosine protein) phosphatases II	DNA ligase/mRNA capping enzyme, catalytic domain	4	1
P-loop containing nucleoside triphosphate hydrolases	TGS-like	4	1
Nucleic acid-binding proteins	Translation proteins SH3-like domain	4	2
DNA-binding domain	FYVE/PHD zinc finger	4	3
Class II aaRS ABD-related	C-terminal domain of ProRS	4	2
PreATP-grasp domain	Aldolase	4	1
Intermediate filament protein, coiled coil region	Lamin A/C globular tail domain	3	1
Kelch motif	EGF/Laminin	3	2
PK beta-barrel domain-like	PK C-terminal domain-like	3	2
P-loop containing nucleoside triphosphate hydrolases	vWA-like	3	2
beta-beta-alpha zinc fingers	WW domain	3	1
UDP-Glycosyltransferase/glycogen phosphorylase	HAD-like	3	1
Actin depolymerizing proteins	VHP, Villin headpiece domain	3	1
L domain-like	Heme-dependent peroxidases	3	2
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	3	2
Flavoproteins	Riboflavin synthase domain-like	3	2
Invasin/intimin cell-adhesion fragments	Invasin/intimin cell-adhesion fragments	3	1
B-box zinc-binding domain	Bromodomain	3	2
ARM repeat	Mib/herc2 domain-like	3	1
Transcription factor STAT-4 N-domain	STAT	3	1
Transducin (heterotrimeric G protein), gamma chain	Regulator of G-protein signaling, RGS	3	3
Ribosomal protein L25-like	Class II aaRS and biotin synthetases	3	1
PLP-dependent transferases	PLP-dependent transferases	3	2
A heparin-binding domain	Amyloid beta a4 protein copper binding domain (domain 2)	3	2
GroES-like	GroES-like	3	1
Smc hinge domain	Tropomyosin	3	3
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	VPS9 domain	3	2
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	3	1
TPR-like	Ankyrin repeat	3	2
Nucleotidylyl transferase	Ribosomal protein L25-like	3	1
cAMP-binding domain-like	Ras GEF	3	2
Second domain of FERM	Second domain of FERM	3	3
PGBD-like	Hemopexin-like domain	3	1
Kelch motif	Fibronectin type III	3	2
ISP domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	3	1
Thyroglobulin type-1 domain	EF-hand	3	3
BEACH domain	WD40 repeat-like	3	1
WD40 repeat-like	Ribonuclease H-like	3	2
Guanido kinase N-terminal domain	Glutamine synthetase/guanido kinase	3	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	3	1
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	3	1
Ribosomal protein L6	Ribosomal protein L6	3	1
NAD(P)-binding Rossmann-fold domains	P-loop containing nucleoside triphosphate hydrolases	3	2
Ankyrin repeat	Voltage-gated potassium channels	3	1
Ribosomal L27 protein-like	Nucleic acid-binding proteins	3	2
Ribosomal protein L25-like	C-terminal domain of ProRS	3	1
Outer arm dynein light chain 1	L domain-like	3	2
Glucocorticoid receptor-like (DNA-binding domain)	Putative DNA-binding domain	3	2
GST C-terminal domain-like	eEF1-gamma domain	3	1
Complement control module/SCR domain	Concanavalin A-like lectins/glucanases	3	3
S15/NS1 RNA-binding domain	S15/NS1 RNA-binding domain	3	1
Glucocorticoid receptor-like (DNA-binding domain)	VPS9 domain	3	2
Alpha subunit of glutamate synthase, C-terminal domain	alpha-helical ferredoxin	3	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Cysteine-rich domain	3	2
POZ domain	beta-beta-alpha zinc fingers	3	3
Glutathione synthetase ATP-binding domain-like	Formyltransferase	3	1
RING/U-box	Ankyrin repeat	3	2
UBA-like	Thioredoxin-like	3	2
Metalloproteases ("zincins"), catalytic domain	Metalloproteases ("zincins"), catalytic domain	3	1
Ribosomal protein L25-like	Class II aaRS ABD-related	3	1
Immunoglobulin	DEATH domain	3	1
C-terminal UvrC-binding domain of UvrB	RuvA domain 2-like	3	1
Tudor/PWWP/MBT	ARID-like	3	2
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	3	2
Chromo domain-like	SET domain	3	2
alpha/beta knot	Nucleic acid-binding proteins	3	2
ISP domain	FAD/NAD(P)-binding domain	3	1
Protein kinase-like (PK-like)	Polo-box domain	3	2
TPR-like	PH domain-like	3	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	3	1
SNARE fusion complex	SNARE fusion complex	3	1
RING/U-box	Cyclophilin-like	3	3
Nucleotidylyl transferase	Class II aaRS and biotin synthetases	3	1
PH domain-like	BSD domain-like	3	1
Spermadhesin, CUB domain	Kelch motif	3	2
DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	3	1
RCC1/BLIP-II	RCC1/BLIP-II	3	2
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	3	2
FYVE/PHD zinc finger	RING/U-box	3	2
Chaperone J-domain	E set domains	3	1
ARM repeat	Ankyrin repeat	3	1
WD40 repeat-like	Cysteine proteinases	3	2
Kringle-like	Kringle-like	3	2
FMN-linked oxidoreductases	alpha-helical ferredoxin	3	1
Ubiquitin-like	DBL homology domain (DH-domain)	3	3
Tudor/PWWP/MBT	SET domain	3	3
Immunoglobulin	Heme-dependent peroxidases	3	2
PABC (PABP) domain	Hect, E3 ligase catalytic domain	3	2
Immunoglobulin	Concanavalin A-like lectins/glucanases	3	3
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	3	2
Actin depolymerizing proteins	SH3-domain	3	1
CCCH zinc finger	Retrovirus zinc finger-like domains	3	2
PH domain-like	Ran binding protein zinc finger-like	3	2
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	3	1
CRAL/TRIO domain	GTPase activation domain, GAP	3	3
FMN-linked oxidoreductases	Nucleotide-binding domain	3	1
B-box zinc-binding domain	FYVE/PHD zinc finger	3	2
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	3	1
MAST3 pre-PK domain-like	PDZ domain-like	3	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	3	1
DEK C-terminal domain	SWIB/MDM2 domain	3	1
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	3	2
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	3	2
Ubiquitin-like	RING/U-box	3	2
LDL receptor-like module	EF-hand	3	1
Nucleoside diphosphate kinase, NDK	Nucleoside diphosphate kinase, NDK	3	2
GroEL apical domain-like	SAICAR synthase-like	3	2
FKBP-like	FKBP-like	3	1
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	3	2
EF-hand	Tropomyosin	3	1
SAM/Pointed domain	ADP-ribosylation	3	1
FnI-like domain	EGF/Laminin	3	3
RING/U-box	NHL repeat	3	2
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	3	1
Regulator of G-protein signaling, RGS	Ubiquitin-like	3	3
SNF-like	SNF-like	3	1
PDZ domain-like	Ras GEF	3	2
E set domains	Cysteine proteinases	3	2
Acetyl-CoA synthetase-like	Quinoprotein alcohol dehydrogenase-like	3	1
PH domain-like	Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	3	1
cAMP-binding domain-like	Ubiquitin-like	3	2
EF-hand	Mitochondrial carrier	3	2
Thyroglobulin type-1 domain	Thyroglobulin type-1 domain	3	3
Ubiquitin-like	Cysteine proteinases	3	2
Hermes dimerisation domain	Ribonuclease H-like	3	1
Cna protein B-type domain	Starch-binding domain-like	3	1
EF-hand	Mannose 6-phosphate receptor domain	3	1
WD40 repeat-like	UBC-like	3	1
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	3	2
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	3	1
Transcription factor STAT-4 N-domain	SH2 domain	3	1
SMAD/FHA domain	PH domain-like	3	2
HSP20-like chaperones	TPR-like	3	1
POZ domain	Homeodomain-like	3	2
YVTN repeat-like/Quinoprotein amine dehydrogenase	Quinoprotein alcohol dehydrogenase-like	3	3
TAFH domain-like	HIT/MYND zinc finger-like	3	2
PH domain-like	VPS9 domain	3	2
Ankyrin repeat	DEATH domain	3	1
Thioredoxin-like	eEF1-gamma domain	3	1
GST C-terminal domain-like	Ribosomal protein L25-like	3	1
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	3	1
Clathrin heavy-chain terminal domain	ARM repeat	3	1
PUA domain-like	SWIB/MDM2 domain	3	2
GST C-terminal domain-like	Class II aaRS and biotin synthetases	3	1
"Winged helix" DNA-binding domain	FYVE/PHD zinc finger	3	2
PurM N-terminal domain-like	Formyltransferase	3	1
Ribosomal protein L25-like	S15/NS1 RNA-binding domain	3	1
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	3	2
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	3	2
PreATP-grasp domain	Formyltransferase	3	1
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	3	1
Ankyrin repeat	SET domain	3	1
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	3	3
WD40 repeat-like	Putative isomerase YbhE	3	3
Alpha subunit of glutamate synthase, C-terminal domain	Nucleotide-binding domain	3	1
Ankyrin repeat	ADP-ribosylation	3	1
Voltage-gated potassium channels	E set domains	3	2
p53-like transcription factors	SH2 domain	3	1
RNA-binding domain, RBD	Eukaryotic type KH-domain (KH-domain type I)	3	2
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	3	1
Leukotriene A4 hydrolase N-terminal domain	Leukotriene A4 hydrolase N-terminal domain	3	1
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	3	2
E set domains	Transglutaminase, two C-terminal domains	3	2
A heparin-binding domain	CAPPD, an extracellular domain of amyloid beta A4 protein	3	2
PRP4-like	WD40 repeat-like	3	2
Acetyl-CoA synthetase-like	ACP-like	3	2
WD40 repeat-like	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	3	2
P-loop containing nucleoside triphosphate hydrolases	Second domain of FERM	3	3
cAMP-binding domain-like	FabD/lysophospholipase-like	3	2
L27 domain	SH3-domain	3	2
GST C-terminal domain-like	Class II aaRS ABD-related	3	1
cAMP-binding domain-like	PDZ domain-like	3	2
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	3	1
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	3	1
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	3	2
DEATH domain	Protein kinase-like (PK-like)	3	1
Nucleotidylyl transferase	Class II aaRS ABD-related	3	1
CCCH zinc finger	RNA-binding domain, RBD	3	2
L27 domain	P-loop containing nucleoside triphosphate hydrolases	3	2
Rudiment single hybrid motif	Formyltransferase	3	1
POZ domain	Skp1 dimerisation domain-like	3	1
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
Kazal-type serine protease inhibitors	Thyroglobulin type-1 domain	3	3
STAT	p53-like transcription factors	3	1
Spermadhesin, CUB domain	Trypsin-like serine proteases	3	1
TSP-1 type 1 repeat	DEATH domain	3	1
Hairpin loop containing domain-like	Hairpin loop containing domain-like	3	2
PDZ domain-like	(Phosphotyrosine protein) phosphatases II	3	2
BSD domain-like	BSD domain-like	3	1
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	3	1
Cysteine proteinases	Ribonuclease H-like	3	2
Chaperone J-domain	Sec63 N-terminal domain-like	3	1
STAT	SH2 domain	3	1
Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	3	2
Protein kinase-like (PK-like)	Class II aaRS and biotin synthetases	3	1
DPP6 N-terminal domain-like	Tubby C-terminal domain-like	3	2
Ankyrin repeat	Protein kinase-like (PK-like)	3	3
SNARE-like	Domain of the SRP/SRP receptor G-proteins	3	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	3	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	3	1
Putative DNA-binding domain	SAND domain-like	3	3
Nucleotidylyl transferase	C-terminal domain of ProRS	3	1
MAST3 pre-PK domain-like	Protein kinase-like (PK-like)	3	1
GST C-terminal domain-like	C-terminal domain of ProRS	3	1
LDL receptor-like module	SRCR-like	3	3
Methylated DNA-protein cysteine methyltransferase domain	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	3	1
Ankyrin repeat	Hect, E3 ligase catalytic domain	3	1
Mib/herc2 domain-like	Hect, E3 ligase catalytic domain	3	1
PurM C-terminal domain-like	Formyltransferase	3	1
Transcription factor STAT-4 N-domain	p53-like transcription factors	3	1
ARID-like	ARM repeat	3	2
Amyloid beta a4 protein copper binding domain (domain 2)	CAPPD, an extracellular domain of amyloid beta A4 protein	3	2
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	3	1
Zinc beta-ribbon	Zinc beta-ribbon	2	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	2	1
EF-hand	Cysteine-rich domain	2	2
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	2	2
"Winged helix" DNA-binding domain	GroEL apical domain-like	2	1
Zinc beta-ribbon	Cyclin-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Fzo-like conserved region	2	2
GTPase activation domain, GAP	VPS9 domain	2	2
Nqo1 middle domain-like	Nqo1C-terminal domain-like	2	1
PH domain-like	Quinoprotein alcohol dehydrogenase-like	2	1
Second domain of FERM	PDZ domain-like	2	1
C-type lectin-like	Fibronectin type III	2	1
BRCT domain	Homeodomain-like	2	1
RCC1/BLIP-II	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	2	2
LDL receptor-like module	Complement control module/SCR domain	2	2
Ubiquitin-like	(Phosphotyrosine protein) phosphatases II	2	1
Ankyrin repeat	SH3-domain	2	2
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	2	2
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	2	2
MOSC N-terminal domain-like	PK beta-barrel domain-like	2	1
Ubiquitin-like	Ran binding protein zinc finger-like	2	1
EF-hand	Immunoglobulin	2	1
Ankyrin repeat	FYVE/PHD zinc finger	2	1
Quinoprotein alcohol dehydrogenase-like	Putative isomerase YbhE	2	2
HCP-like	SAM/Pointed domain	2	1
Nucleotide-diphospho-sugar transferases	IpsF-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Ubiquitin-like	2	2
FYVE/PHD zinc finger	Elongation factor TFIIS domain 2	2	2
Cation efflux protein transmembrane domain-like	Cation efflux protein transmembrane domain-like	2	1
LDL receptor-like module	Galactose-binding domain-like	2	2
Immunoglobulin	Hormone receptor domain	2	2
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Folate-binding domain	Aminomethyltransferase beta-barrel domain	2	1
Growth factor receptor domain	SAM/Pointed domain	2	1
PTS-regulatory domain, PRD	Phoshotransferase/anion transport protein	2	1
BRCT domain	WGR domain-like	2	1
WD40 repeat-like	EF-hand	2	2
PH domain-like	A middle domain of Talin 1	2	1
ARM repeat	WWE domain	2	1
BRCT domain	PH domain-like	2	2
Galactose-binding domain-like	SAM/Pointed domain	2	1
PP2C-like	PP2C-like	2	1
Putative DNA-binding domain	Cation efflux protein transmembrane domain-like	2	1
MIR domain	ARM repeat	2	1
BRCT domain	Domain of poly(ADP-ribose) polymerase	2	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	2	1
TSP type-3 repeat	TSP type-3 repeat	2	2
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	2	1
Radical SAM enzymes	Molybdenum cofactor biosynthesis protein C, MoaC	2	1
PDZ domain-like	BAR/IMD domain-like	2	1
Saposin	Metallo-dependent phosphatases	2	1
Ribosomal protein S5 domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	2	2
ARM repeat	Rap/Ran-GAP	2	1
WD40 repeat-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	2
Heme-dependent peroxidases	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	1
LDL receptor-like module	Terpenoid cyclases/Protein prenyltransferases	2	2
DNase I-like	RNA-binding domain, RBD	2	1
Dcp2 domain-like	Nudix	2	1
I/LWEQ domain	alpha-catenin/vinculin-like	2	1
Hormone receptor domain	Family A G protein-coupled receptor-like	2	1
Putative isomerase YbhE	TPR-like	2	2
DNase I-like	DNA/RNA polymerases	2	1
Single hybrid motif	ClpP/crotonase	2	1
E set domains	RING/U-box	2	1
PH domain-like	alpha-catenin/vinculin-like	2	1
ARM repeat	Cysteine proteinases	2	1
Thiolase-like	SCP-like	2	1
C-type lectin-like	Immunoglobulin	2	1
Concanavalin A-like lectins/glucanases	BEACH domain	2	2
lambda repressor-like DNA-binding domains	lambda repressor-like DNA-binding domains	2	1
Heme-dependent peroxidases	Heme-dependent peroxidases	2	1
Sema domain	TSP-1 type 1 repeat	2	2
RNA-binding domain, RBD	PABC (PABP) domain	2	1
ARM repeat	GTPase activation domain, GAP	2	2
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	2	1
A middle domain of Talin 1	I/LWEQ domain	2	1
Spermadhesin, CUB domain	Concanavalin A-like lectins/glucanases	2	2
Plexin repeat	Integrin beta tail domain	2	1
Second domain of FERM	A middle domain of Talin 1	2	1
Galactose-binding domain-like	RING/U-box	2	1
SH2 domain	Ras GEF	2	1
Plexin repeat	TSP-1 type 1 repeat	2	2
CHY zinc finger-like	Zinc hairpin stack	2	1
FMT C-terminal domain-like	ALDH-like	2	1
Cysteine-rich domain	GTPase activation domain, GAP	2	2
Myosin rod fragments	Mitotic arrest deficient-like 1, Mad1	2	2
Lipovitellin-phosvitin complex, superhelical domain	ARM repeat	2	1
PIN domain-like	Nucleic acid-binding proteins	2	1
Serine protease inhibitors	FnI-like domain	2	2
Plexin repeat	EGF/Laminin	2	1
Calponin-homology domain, CH-domain	GAS2 domain-like	2	1
L domain-like	Calponin-homology domain, CH-domain	2	1
POZ domain	FYVE/PHD zinc finger	2	1
Carbamate kinase-like	ALDH-like	2	1
A middle domain of Talin 1	alpha-catenin/vinculin-like	2	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	2	1
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	2	1
NAD(P)-binding Rossmann-fold domains	Thioesterase/thiol ester dehydrase-isomerase	2	1
WGR domain-like	Domain of poly(ADP-ribose) polymerase	2	1
PTS-regulatory domain, PRD	PTS system IIB component-like	2	1
UBA-like	NSFL1 (p97 ATPase) cofactor p47, SEP domain	2	1
Inosine monophosphate dehydrogenase (IMPDH)	Inosine monophosphate dehydrogenase (IMPDH)	2	2
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	2	1
FYVE/PHD zinc finger	SAICAR synthase-like	2	1
SAM/Pointed domain	PH domain-like	2	2
Heme-dependent peroxidases	EF-hand	2	1
Eukaryotic type KH-domain (KH-domain type I)	Retrovirus zinc finger-like domains	2	1
FAD/NAD(P)-binding domain	Calponin-homology domain, CH-domain	2	1
"Winged helix" DNA-binding domain	SAICAR synthase-like	2	1
RNA-binding domain, RBD	DPP6 N-terminal domain-like	2	1
ISP transmembrane anchor	ISP domain	2	2
RCC1/BLIP-II	PH domain-like	2	2
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	2	1
PX domain	Protein kinase-like (PK-like)	2	2
Second domain of FERM	(Phosphotyrosine protein) phosphatases II	2	1
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	2	1
PDZ domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
L domain-like	EGF/Laminin	2	2
Staphylococcal nuclease	Tudor/PWWP/MBT	2	2
GST C-terminal domain-like	eEF-1beta-like	2	1
LDL receptor-like module	Protein kinase-like (PK-like)	2	2
Spermadhesin, CUB domain	Complement control module/SCR domain	2	2
Ankyrin repeat	PDZ domain-like	2	2
SRCR-like	SRCR-like	2	2
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	2	1
beta-beta-alpha zinc fingers	Homeodomain-like	2	2
Thioredoxin-like	Ubiquitin-like	2	1
FAD/NAD(P)-binding domain	EF-hand	2	2
TSP type-3 repeat	Concanavalin A-like lectins/glucanases	2	2
Staphylococcal nuclease	Staphylococcal nuclease	2	2
Plexin repeat	Integrin domains	2	1
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	2	1
EF-hand	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
SEA domain	EGF/Laminin	2	1
Nitrous oxide reductase, N-terminal domain	WD40 repeat-like	2	1
PDZ domain-like	PX domain	2	1
Fibronectin type III	YWTD domain	2	1
Tubulin nucleotide-binding domain-like	Tubulin nucleotide-binding domain-like	2	1
THUMP domain-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	2	2
Glucocorticoid receptor-like (DNA-binding domain)	VHP, Villin headpiece domain	2	2
Macro domain-like	Zn-dependent exopeptidases	2	1
Succinyl-CoA synthetase domains	Citrate synthase	2	1
Mib/herc2 domain-like	Mib/herc2 domain-like	2	2
Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	2	2
Acyl-CoA binding protein	Supernatant protein factor (SPF), C-terminal domain	2	2
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	2	2
Glucocorticoid receptor-like (DNA-binding domain)	Ubiquitin-like	2	1
Sec63 N-terminal domain-like	DNA/RNA polymerases	2	2
PH domain-like	I/LWEQ domain	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	1
RING/U-box	RNA-binding domain, RBD	2	2
TRAF domain-like	TRAF domain-like	2	2
"Winged helix" DNA-binding domain	Transducin (heterotrimeric G protein), gamma chain	2	2
PX domain	Ubiquitin-like	2	1
FMN-linked oxidoreductases	dsRNA-binding domain-like	2	1
Ankyrin repeat	L domain-like	2	2
FAD/NAD(P)-binding domain	Glucocorticoid receptor-like (DNA-binding domain)	2	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	PAZ domain	2	2
PreATP-grasp domain	ClpP/crotonase	2	1
Galactose oxidase, central domain	Fibronectin type III	2	1
RING/U-box	WWE domain	2	2
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	2	2
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	2	1
PTS system IIB component-like	Phoshotransferase/anion transport protein	2	1
Ribosomal protein S5 domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	2	2
FAD-linked reductases, C-terminal domain	EF-hand	2	2
RNI-like	Ubiquitin-like	2	1
Ubiquitin-like	FYVE/PHD zinc finger	2	1
E set domains	Hect, E3 ligase catalytic domain	2	2
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	2	2
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	2	1
E set domains	Galactose-binding domain-like	2	1
PAZ domain	dsRNA-binding domain-like	2	2
NAD(P)-binding Rossmann-fold domains	Citrate synthase	2	1
WWE domain	Hect, E3 ligase catalytic domain	2	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	2	1
Ubiquitin-like	Moesin tail domain	2	1
FAD-linked reductases, C-terminal domain	FAD-linked reductases, C-terminal domain	2	1
UBA-like	P-loop containing nucleoside triphosphate hydrolases	2	1
P-loop containing nucleoside triphosphate hydrolases	TrmE connector domain	2	2
Methuselah ectodomain	Family A G protein-coupled receptor-like	2	1
TPR-like	RNA-binding domain, RBD	2	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	2	1
"Winged helix" DNA-binding domain	occludin/ELL-like	2	1
BRCA2 helical domain	Nucleic acid-binding proteins	2	2
DBL homology domain (DH-domain)	WD40 repeat-like	2	1
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	2	1
Chaperone J-domain	RNA-binding domain, RBD	2	1
SH3-domain	Fibronectin type III	2	1
PUA domain-like	eIF1-like	2	1
PX domain	BAR/IMD domain-like	2	2
FYVE/PHD zinc finger	GroEL apical domain-like	2	1
Phenylalanine zipper	PH domain-like	2	1
DNase I-like	GTPase activation domain, GAP	2	2
Taf5 N-terminal domain-like	WD40 repeat-like	2	1
Doublecortin (DC)	POZ domain	2	1
YWTD domain	Protein kinase-like (PK-like)	2	1
ARM repeat	EF-hand	2	1
Formyltransferase	ALDH-like	2	1
Formyltransferase	FMT C-terminal domain-like	2	1
Second domain of FERM	alpha-catenin/vinculin-like	2	1
Tetrapyrrole methylase	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Surp module (SWAP domain)	ENTH/VHS domain	2	1
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	2	1
POZ domain	Pentapeptide repeat-like	2	1
L domain-like	Concanavalin A-like lectins/glucanases	2	2
Sema domain	Immunoglobulin	2	1
I/LWEQ domain	I/LWEQ domain	2	1
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	2	1
t-snare proteins	SNARE fusion complex	2	2
alpha/beta-Hydrolases	alpha/beta-Hydrolases	2	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	ARM repeat	2	1
TATA-box binding protein-like	TATA-box binding protein-like	2	2
CBS-domain pair	cAMP-binding domain-like	2	1
DNA polymerase beta, N-terminal domain-like	Restriction endonuclease-like	2	1
HCP-like	Protein kinase-like (PK-like)	2	1
Heme-dependent peroxidases	Riboflavin synthase domain-like	2	1
Thioesterase/thiol ester dehydrase-isomerase	SCP-like	2	1
FYVE/PHD zinc finger	S-adenosyl-L-methionine-dependent methyltransferases	2	2
IP3 receptor type 1 binding core, domain 2	ARM repeat	2	1
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
Spermadhesin, CUB domain	Galactose-binding domain-like	2	2
TPR-like	Ran binding protein zinc finger-like	2	1
Ribonuclease H-like	HRDC-like	2	2
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	2	1
Cytochrome b5-like heme/steroid binding domain	Riboflavin synthase domain-like	2	2
Galactose-binding domain-like	BRCT domain	2	1
P-loop containing nucleoside triphosphate hydrolases	RNase III domain-like	2	2
Ubiquitin-like	Zn-binding ribosomal proteins	2	1
Nucleotide cyclase	P-loop containing nucleoside triphosphate hydrolases	2	1
LDL receptor-like module	L domain-like	2	2
Concanavalin A-like lectins/glucanases	PH domain-like	2	2
ARM repeat	CRAL/TRIO domain	2	2
GFP-like	EGF/Laminin	2	2
TPR-like	Clavaminate synthase-like	2	1
BRCT domain	ADP-ribosylation	2	1
PLC-like phosphodiesterases	Ubiquitin-like	2	2
Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	2	2
DAK1/DegV-like	DhaL-like	2	1
FYVE/PHD zinc finger	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
P-loop containing nucleoside triphosphate hydrolases	MOP-like	2	1
PAZ domain	RNase III domain-like	2	2
WGR domain-like	ADP-ribosylation	2	1
"Winged helix" DNA-binding domain	Regulator of G-protein signaling, RGS	2	2
B-box zinc-binding domain	TRAF domain-like	2	1
vWA-like	Complement control module/SCR domain	2	2
P-loop containing nucleoside triphosphate hydrolases	SOCS box-like	2	1
Rudiment single hybrid motif	ClpP/crotonase	2	1
CCHHC domain	CCHHC domain	2	2
Thioredoxin-like	ERP29 C domain-like	2	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	2	1
PUA domain-like	Nucleotidylyl transferase	2	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	2	2
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	2	1
Phosphofructokinase	Phosphofructokinase	2	1
PX domain	MIT domain	2	2
RUN domain-like	FYVE/PHD zinc finger	2	1
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	2	1
MIT domain	Protein kinase-like (PK-like)	2	2
Mib/herc2 domain-like	RING/U-box	2	2
Kazal-type serine protease inhibitors	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
Ribonuclease PH domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	2	2
LDL receptor-like module	Family A G protein-coupled receptor-like	2	2
Doublecortin (DC)	Pentapeptide repeat-like	2	1
DBL homology domain (DH-domain)	Quinoprotein alcohol dehydrogenase-like	2	1
Protein kinase-like (PK-like)	L27 domain	2	1
Calponin-homology domain, CH-domain	Glucocorticoid receptor-like (DNA-binding domain)	2	1
P-loop containing nucleoside triphosphate hydrolases	Nucleotidylyl transferase	2	1
SH3-domain	ARM repeat	2	1
Glutathione synthetase ATP-binding domain-like	NAD(P)-binding Rossmann-fold domains	2	1
LDL receptor-like module	Alpha-macroglobulin receptor domain	2	2
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	1
Plexin repeat	Immunoglobulin	2	1
EF-hand	Isochorismatase-like hydrolases	2	1
PH domain-like	Bet v1-like	2	1
CRAL/TRIO domain	(Phosphotyrosine protein) phosphatases II	2	2
FYVE/PHD zinc finger	PUA domain-like	2	1
Glutathione synthetase ATP-binding domain-like	Citrate synthase	2	1
NAD kinase/diacylglycerol kinase-like	SAM/Pointed domain	2	1
L domain-like	Actin depolymerizing proteins	2	1
Ankyrin repeat	FabD/lysophospholipase-like	2	2
DBL homology domain (DH-domain)	BAR/IMD domain-like	2	2
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	2	1
E set domains	Ankyrin repeat	2	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	2	1
RNA-binding domain, RBD	Class II aaRS ABD-related	2	2
DNA-binding protein LAG-1 (CSL)	E set domains	2	2
Kazal-type serine protease inhibitors	Immunoglobulin	2	1
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	2	1
Second domain of FERM	DBL homology domain (DH-domain)	2	2
Phenylalanine zipper	SH2 domain	2	1
Second domain of FERM	I/LWEQ domain	2	1
GDNF receptor-like	GDNF receptor-like	2	2
Ubiquitin-like	PUA domain-like	2	1
Hypothetical protein c14orf129, hspc210	TPR-like	2	1
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	2	2
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	2	2
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Eukaryotic type KH-domain (KH-domain type I)	2	2
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	2	1
PRTase-like	PRTase-like	2	1
Cadherin-like	Growth factor receptor domain	2	2
SWIB/MDM2 domain	eIF1-like	2	1
Immunoglobulin	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	2	1
Fibronectin type III	SAM/Pointed domain	2	1
Homeodomain-like	Ribonuclease H-like	1	1
Homeodomain-like	Bromodomain	1	1
HesB-like domain	HesB-like domain	1	1
P-loop containing nucleoside triphosphate hydrolases	RGC domain-like	1	1
PDZ domain-like	RING/U-box	1	1
FKBP-like	EF-hand	1	1
C-type lectin-like	LDL receptor-like module	1	1
Cap-Gly domain	Cysteine proteinases	1	1
Serine protease inhibitors	Invertebrate chitin-binding proteins	1	1
GTPase activation domain, GAP	Ubiquitin-like	1	1
SH3-domain	SAM/Pointed domain	1	1
Ras GEF	EF-hand	1	1
BPTI-like	Concanavalin A-like lectins/glucanases	1	1
Cystatin/monellin	Cysteine proteinases	1	1
Translation proteins	ThrRS/AlaRS common domain	1	1
Doublecortin (DC)	Quinoprotein alcohol dehydrogenase-like	1	1
vWA-like	Concanavalin A-like lectins/glucanases	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
HAD-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Protein kinase-like (PK-like)	KA1-like	1	1
FnI-like domain	Galactose-binding domain-like	1	1
Invertebrate chitin-binding proteins	SRCR-like	1	1
DBL homology domain (DH-domain)	GTPase activation domain, GAP	1	1
Thiolase-like	Thioredoxin-like	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
FGAM synthase PurL, linker domain	PurM N-terminal domain-like	1	1
F-box domain	UBC-like	1	1
PH domain-like	HMG-box	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
RNI-like	Toll/Interleukin receptor TIR domain	1	1
Uracil-DNA glycosylase-like	Cytidine deaminase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Putative isomerase YbhE	1	1
FYVE/PHD zinc finger	Acyl-CoA N-acyltransferases (Nat)	1	1
PUG domain-like	Ubiquitin-like	1	1
SH3-domain	Phosphoglycerate mutase-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
TPR-like	Fic-like	1	1
WD40 repeat-like	Cyclophilin-like	1	1
Rhodanese/Cell cycle control phosphatase	Cysteine proteinases	1	1
BRCA2 helical domain	BRCA2 tower domain	1	1
SAM/Pointed domain	RING/U-box	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	Homeodomain-like	1	1
RING/U-box	UBA-like	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	YWTD domain	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
vWA-like	Growth factor receptor domain	1	1
Ras GEF	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Multidrug efflux transporter AcrB transmembrane domain	Quinoprotein alcohol dehydrogenase-like	1	1
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	1	1
ARM repeat	Thioesterase/thiol ester dehydrase-isomerase	1	1
TROVE domain-like	vWA-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	Tudor/PWWP/MBT	1	1
RCC1/BLIP-II	VPS9 domain	1	1
FYVE/PHD zinc finger	SAP domain	1	1
Complement control module/SCR domain	Immunoglobulin	1	1
RNI-like	Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain	1	1
L domain-like	Pectin lyase-like	1	1
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	1	1
PH domain-like	"Winged helix" DNA-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	1	1
Apolipoprotein A-I	Apolipoprotein A-I	1	1
VPS9 domain	Ubiquitin-like	1	1
Cysteine proteinases	Cysteine proteinases	1	1
WD40 repeat-like	SAM/Pointed domain	1	1
Leech antihemostatic proteins	BPTI-like	1	1
SMAD/FHA domain	HAD-like	1	1
POZ domain	Galactose-binding domain-like	1	1
PX domain	GTPase activation domain, GAP	1	1
14-3-3 protein	14-3-3 protein	1	1
N-acetylmuramoyl-L-alanine amidase-like	PGBD-like	1	1
Cadherin-like	Protein kinase-like (PK-like)	1	1
NHL repeat	WD40 repeat-like	1	1
Second domain of FERM	RING/U-box	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	LDL receptor-like module	1	1
TAFH domain-like	Histone-fold	1	1
p53-like transcription factors	DNA-binding protein LAG-1 (CSL)	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
beta-lactamase/transpeptidase-like	Ankyrin repeat	1	1
(Phosphotyrosine protein) phosphatases II	Cysteine-rich domain	1	1
Ubiquitin-like	HAD-like	1	1
FLJ32549 domain-like	FLJ32549 C-terminal domain-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	S15/NS1 RNA-binding domain	1	1
F-box domain	Pectin lyase-like	1	1
Frizzled cysteine-rich domain	LDL receptor-like module	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	Methylated DNA-protein cysteine methyltransferase domain	1	1
Folate-binding domain	TrmE connector domain	1	1
FYVE/PHD zinc finger	BRK domain-like	1	1
C-type lectin-like	Concanavalin A-like lectins/glucanases	1	1
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	1	1
UBA-like	Phosphoglycerate mutase-like	1	1
TSP-1 type 1 repeat	Spermadhesin, CUB domain	1	1
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
F-box domain	Galactose-binding domain-like	1	1
Growth factor receptor domain	TSP type-3 repeat	1	1
Histone-fold	POZ domain	1	1
Molybdenum cofactor biosynthesis proteins	MoeA N-terminal region -like	1	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	1	1
Quinoprotein alcohol dehydrogenase-like	F-box domain	1	1
Quinoprotein alcohol dehydrogenase-like	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	1	1
RING/U-box	P-loop containing nucleoside triphosphate hydrolases	1	1
Homeodomain-like	FYVE/PHD zinc finger	1	1
ARM repeat	RING/U-box	1	1
Seven-hairpin glycosidases	PA domain	1	1
E set domains	Complement control module/SCR domain	1	1
Homeodomain-like	SIS domain	1	1
SET domain	WW domain	1	1
Outer arm dynein light chain 1	P-loop containing nucleoside triphosphate hydrolases	1	1
PDZ domain-like	GTPase activation domain, GAP	1	1
PurS-like	PurM C-terminal domain-like	1	1
WW domain	EF-hand	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
Trypsin-like serine proteases	PDZ domain-like	1	1
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
MIT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
FAD-linked reductases, C-terminal domain	MoaD/ThiS	1	1
WWE domain	WWE domain	1	1
Cysteine proteinases	UBA-like	1	1
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	1	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	1	1
CAPPD, an extracellular domain of amyloid beta A4 protein	CAPPD, an extracellular domain of amyloid beta A4 protein	1	1
Tudor/PWWP/MBT	Chromo domain-like	1	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Nucleic acid-binding proteins	1	1
YccV-like	ApaG-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
XPC-binding domain	UBA-like	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
PKD domain	PKD domain	1	1
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	1	1
RCC1/BLIP-II	POZ domain	1	1
PLP-dependent transferases	Adenine nucleotide alpha hydrolases-like	1	1
RING/U-box	Bromodomain	1	1
Serine protease inhibitors	Serine protease inhibitors	1	1
B-box zinc-binding domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	CCCH zinc finger	1	1
Sigma2 domain of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	1	1
a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	1	1
WW domain	RING/U-box	1	1
Tudor/PWWP/MBT	DNA-binding domain	1	1
beta-beta-alpha zinc fingers	Nucleotide-diphospho-sugar transferases	1	1
Thyroglobulin type-1 domain	Leech antihemostatic proteins	1	1
CRAL/TRIO domain	SH3-domain	1	1
Methylglyoxal synthase-like	Cytidine deaminase-like	1	1
PH domain-like	FYVE/PHD zinc finger	1	1
Ribosomal protein S5 domain 2-like	Nucleic acid-binding proteins	1	1
Tricorn protease domain 2	EF-hand	1	1
TPR-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
PTS system fructose IIA component-like	PTS IIb component	1	1
Quinoprotein alcohol dehydrogenase-like	Tricorn protease domain 2	1	1
RAP domain-like	RAP domain-like	1	1
Single hybrid motif	NAD(P)-binding Rossmann-fold domains	1	1
RNA-binding domain, RBD	Tricorn protease domain 2	1	1
TRAF domain-like	POZ domain	1	1
Leech antihemostatic proteins	Leech antihemostatic proteins	1	1
Cystatin/monellin	Cystatin/monellin	1	1
Thioredoxin-like	TPR-like	1	1
Homeodomain-like	Methylated DNA-protein cysteine methyltransferase domain	1	1
Zinc beta-ribbon	YrdC/RibB	1	1
Invertebrate chitin-binding proteins	Galactose-binding domain-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	1	1
BRCT domain	DNA/RNA polymerases	1	1
ARM repeat	SAM/Pointed domain	1	1
WD40 repeat-like	Bromodomain	1	1
UBA-like	SH3-domain	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
Thioredoxin-like	Galactose-binding domain-like	1	1
Cytochrome b5-like heme/steroid binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Thyroglobulin type-1 domain	BPTI-like	1	1
SMAD/FHA domain	"Winged helix" DNA-binding domain	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
L domain-like	Ubiquitin-like	1	1
EGF/Laminin	TSP type-3 repeat	1	1
Regulator of G-protein signaling, RGS	PH domain-like	1	1
PDZ domain-like	Regulator of G-protein signaling, RGS	1	1
Frizzled cysteine-rich domain	SRCR-like	1	1
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
Concanavalin A-like lectins/glucanases	Protein kinase-like (PK-like)	1	1
Ras GEF	PLC-like phosphodiesterases	1	1
CoA-dependent acyltransferases	NAD(P)-binding Rossmann-fold domains	1	1
Ypt/Rab-GAP domain of gyp1p	Rhodanese/Cell cycle control phosphatase	1	1
HMG-box	HMG-box	1	1
SAM/Pointed domain	Toll/Interleukin receptor TIR domain	1	1
TPR-like	Protein prenylyltransferase	1	1
SH2 domain	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
DNA-binding domain	Homeodomain-like	1	1
Regulator of G-protein signaling, RGS	DBL homology domain (DH-domain)	1	1
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	1	1
PurS-like	FGAM synthase PurL, linker domain	1	1
Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	1	1
Actin-like ATPase domain	AF1104-like	1	1
TPR-like	ARM repeat	1	1
Pectin lyase-like	Pectin lyase-like	1	1
SET domain	Bromodomain	1	1
Histone-fold	Ankyrin repeat	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	UBA-like	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	S15/NS1 RNA-binding domain	1	1
Rap/Ran-GAP	PDZ domain-like	1	1
Frizzled cysteine-rich domain	Trypsin-like serine proteases	1	1
P-loop containing nucleoside triphosphate hydrolases	Tudor/PWWP/MBT	1	1
GMP synthetase C-terminal dimerisation domain	GMP synthetase C-terminal dimerisation domain	1	1
Activator of Hsp90 ATPase, Aha1	Bet v1-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Nucleic acid-binding proteins	1	1
Elafin-like	Elafin-like	1	1
Ubiquitin-like	Cap-Gly domain	1	1
RNI-like	Immunoglobulin	1	1
TPR-like	RNI-like	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	1	1
Ankyrin repeat	RNI-like	1	1
Serine protease inhibitors	Galactose-binding domain-like	1	1
L domain-like	PDZ domain-like	1	1
C-type lectin-like	Growth factor receptor domain	1	1
BRCT domain	Lesion bypass DNA polymerase (Y-family), little finger domain	1	1
His-Me finger endonucleases	His-Me finger endonucleases	1	1
Nitric oxide (NO) synthase oxygenase domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Protein kinase-like (PK-like)	NTF2-like	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	1	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	1	1
"Winged helix" DNA-binding domain	Dimeric alpha+beta barrel	1	1
B-box zinc-binding domain	Cyclophilin-like	1	1
Nitric oxide (NO) synthase oxygenase domain	Flavoproteins	1	1
PX domain	Outer arm dynein light chain 1	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ATP-dependent DNA ligase DNA-binding domain	1	1
Calcyclin-binding protein-like	HSP20-like chaperones	1	1
PRTase-like	Ribulose-phoshate binding barrel	1	1
Heat shock protein 70kD (HSP70), C-terminal subdomain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Zinc hairpin stack	Retrovirus zinc finger-like domains	1	1
FYVE/PHD zinc finger	PDZ domain-like	1	1
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
WD40 repeat-like	Galactose oxidase, central domain	1	1
Aminoacid dehydrogenase-like, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
TrkA C-terminal domain-like	TrkA C-terminal domain-like	1	1
Pseudouridine synthase	(Phosphotyrosine protein) phosphatases II	1	1
C-type lectin-like	Spermadhesin, CUB domain	1	1
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	1	1
Voltage-gated potassium channels	Small-conductance potassium channel	1	1
CRAL/TRIO N-terminal domain	(Phosphotyrosine protein) phosphatases II	1	1
Dystroglycan, domain 2	Cadherin-like	1	1
Phoshotransferase/anion transport protein	Phoshotransferase/anion transport protein	1	1
CAD & PB1 domains	PDZ domain-like	1	1
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	1	1
Chaperone J-domain	CSL zinc finger	1	1
DEATH domain	Toll/Interleukin receptor TIR domain	1	1
FAH	FAH	1	1
PDZ domain-like	Cysteine-rich domain	1	1
EGF/Laminin	TIMP-like	1	1
ARM repeat	Toll/Interleukin receptor TIR domain	1	1
Eukaryotic type KH-domain (KH-domain type I)	P-loop containing nucleoside triphosphate hydrolases	1	1
Tropomyosin	Mitotic arrest deficient-like 1, Mad1	1	1
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	1	1
BRK domain-like	Elongation factor TFIIS domain 2	1	1
Ubiquitin-like	Acid proteases	1	1
HR1 repeat	PDZ domain-like	1	1
TPR-like	Metallo-dependent phosphatases	1	1
P-loop containing nucleoside triphosphate hydrolases	SET domain	1	1
GST C-terminal domain-like	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
ENTH/VHS domain	RNA-binding domain, RBD	1	1
Elafin-like	Fibronectin type III	1	1
SAND domain-like	HIT/MYND zinc finger-like	1	1
EF-hand	Ubiquitin-like	1	1
HRDC-like	HRDC-like	1	1
MoaD/ThiS	ThiG-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheY-like	1	1
PurS-like	PurM N-terminal domain-like	1	1
L domain-like	Hormone receptor domain	1	1
DNA-binding domain	SET domain	1	1
FnI-like domain	Invertebrate chitin-binding proteins	1	1
UBC-like	UBA-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
ARID-like	Chromo domain-like	1	1
WW domain	PH domain-like	1	1
PH domain-like	RING/U-box	1	1
ARM repeat	UBA-like	1	1
RING/U-box	Tropomyosin	1	1
Nitric oxide (NO) synthase oxygenase domain	Riboflavin synthase domain-like	1	1
Actin-crosslinking proteins	Actin-crosslinking proteins	1	1
UBC-like	Protein kinase-like (PK-like)	1	1
WD40 repeat-like	Tricorn protease domain 2	1	1
Chaperone J-domain	Chaperone J-domain	1	1
EF-hand	NAD kinase/diacylglycerol kinase-like	1	1
"Winged helix" DNA-binding domain	PLP-dependent transferases	1	1
Bacterial hemolysins	Tropomyosin	1	1
Nucleic acid-binding proteins	BRCA2 tower domain	1	1
Invertebrate chitin-binding proteins	Trypsin-like serine proteases	1	1
beta-Roll	beta-Roll	1	1
FGAM synthase PurL, linker domain	PurM C-terminal domain-like	1	1
HIT-like	HIT-like	1	1
FAD-linked reductases, C-terminal domain	ThiG-like	1	1
Outer arm dynein light chain 1	Toll/Interleukin receptor TIR domain	1	1
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	1	1
AMMECR1-like	AMMECR1-like	1	1
Arabinanase/levansucrase/invertase	Concanavalin A-like lectins/glucanases	1	1
beta-beta-alpha zinc fingers	FYVE/PHD zinc finger	1	1
SMAD/FHA domain	Protein kinase-like (PK-like)	1	1
PH domain-like	Cullin repeat-like	1	1
DPP6 N-terminal domain-like	ARM repeat	1	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
C-type lectin-like	EGF/Laminin	1	1
Glucocorticoid receptor-like (DNA-binding domain)	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
Multidrug efflux transporter AcrB transmembrane domain	WD40 repeat-like	1	1
L domain-like	PP2C-like	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	1	1
GST C-terminal domain-like	Methionyl-tRNA synthetase (MetRS), Zn-domain	1	1
"Winged helix" DNA-binding domain	Acyl-CoA N-acyltransferases (Nat)	1	1
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
Saposin	Saposin	1	1