Domain combination pairs in Apis mellifera 38.2d

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

1607 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	354	52
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	294	84
Immunoglobulin	Immunoglobulin	226	96
EGF/Laminin	EGF/Laminin	109	87
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	97	9
Immunoglobulin	Fibronectin type III	94	55
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	83	29
L domain-like	L domain-like	80	42
Fibronectin type III	Fibronectin type III	77	46
EGF/Laminin	Growth factor receptor domain	72	66
TPR-like	TPR-like	69	18
Cadherin-like	Cadherin-like	66	41
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	65	11
HAD-like	Calcium ATPase, transmembrane domain M	65	11
Calcium ATPase, transduction domain A	HAD-like	64	10
Growth factor receptor domain	Growth factor receptor domain	64	55
RNA-binding domain, RBD	RNA-binding domain, RBD	63	18
Nicotinic receptor ligand binding domain-like	Neurotransmitter-gated ion-channel transmembrane pore	60	2
ABC transporter transmembrane region	ABC transporter transmembrane region	60	7
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	60	8
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	56	6
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	55	5
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	55	5
ARM repeat	ARM repeat	53	23
Glucocorticoid receptor-like (DNA-binding domain)	Nuclear receptor ligand-binding domain	52	6
Voltage-gated potassium channels	Voltage-gated potassium channels	50	10
DBL homology domain (DH-domain)	PH domain-like	49	30
TSP-1 type 1 repeat	TSP-1 type 1 repeat	46	28
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	44	17
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	43	11
Homeodomain-like	Homeodomain-like	42	14
E set domains	E set domains	42	17
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	41	4
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	40	3
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	39	28
(Trans)glycosidases	Chitinase insertion domain	38	10
BAR/IMD domain-like	SH3-domain	38	8
Second domain of FERM	PH domain-like	38	24
EGF/Laminin	Concanavalin A-like lectins/glucanases	38	30
EF-hand	EF-hand	37	17
Spectrin repeat	Spectrin repeat	36	24
MFS general substrate transporter	Kazal-type serine protease inhibitors	36	5
Actin-like ATPase domain	Actin-like ATPase domain	35	8
PH domain-like	PH domain-like	33	23
Periplasmic binding protein-like I	Periplasmic binding protein-like II	33	6
LDL receptor-like module	LDL receptor-like module	33	29
PDZ domain-like	PDZ domain-like	32	16
PDZ domain-like	P-loop containing nucleoside triphosphate hydrolases	32	13
Cyclin-like	Cyclin-like	31	6
ARM repeat	Protein kinase-like (PK-like)	30	12
SH3-domain	P-loop containing nucleoside triphosphate hydrolases	29	10
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	28	8
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	28	4
Ubiquitin-like	Ubiquitin-like	28	18
PDZ domain-like	SH3-domain	27	12
Invertebrate chitin-binding proteins	Invertebrate chitin-binding proteins	27	14
RNI-like	L domain-like	27	14
Glucocorticoid receptor-like (DNA-binding domain)	Homeodomain-like	27	8
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	27	11
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	26	7
Spermadhesin, CUB domain	Spermadhesin, CUB domain	26	20
Ubiquitin-like	PH domain-like	26	18
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	26	4
GroES-like	NAD(P)-binding Rossmann-fold domains	25	6
Translation proteins	EF-G C-terminal domain-like	25	6
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	24	8
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	24	11
Metalloproteases ("zincins"), catalytic domain	TSP-1 type 1 repeat	24	11
WW domain	WW domain	24	14
FYVE/PHD zinc finger	FYVE/PHD zinc finger	24	13
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	24	6
Ankyrin repeat	Ankyrin repeat	24	13
Subtilisin-like	Galactose-binding domain-like	23	6
Chitinase insertion domain	Invertebrate chitin-binding proteins	23	8
WD40 repeat-like	WD40 repeat-like	23	7
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	23	8
POZ domain	Kelch motif	23	6
(Trans)glycosidases	Invertebrate chitin-binding proteins	23	8
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	23	9
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	22	2
Thioredoxin-like	GST C-terminal domain-like	22	2
Ubiquitin-like	Second domain of FERM	22	14
Terpenoid cyclases/Protein prenyltransferases	Alpha-macroglobulin receptor domain	21	5
EF-G C-terminal domain-like	EF-G C-terminal domain-like	21	4
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	21	7
SH2 domain	SH3-domain	21	7
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	21	3
HLH, helix-loop-helix DNA-binding domain	PYP-like sensor domain (PAS domain)	21	7
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	20	4
HLH, helix-loop-helix DNA-binding domain	Orange domain-like	20	3
SH3-domain	SH3-domain	20	11
Nucleotide cyclase	Nucleotide cyclase	20	3
ARM repeat	Formin homology 2 domain (FH2 domain)	19	4
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	19	6
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	19	6
F-box domain	RNI-like	19	4
Fibronectin type III	Protein kinase-like (PK-like)	19	10
C-type lectin-like	C-type lectin-like	19	1
SH2 domain	Protein kinase-like (PK-like)	19	6
Cadherin-like	Concanavalin A-like lectins/glucanases	19	14
Calponin-homology domain, CH-domain	Spectrin repeat	19	13
Voltage-gated potassium channels	cAMP-binding domain-like	19	5
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	19	2
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	19	6
Cupredoxins	Cupredoxins	19	6
Sec7 domain	ARM repeat	19	6
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	19	2
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	18	5
Galactose-binding domain-like	Growth factor receptor domain	18	9
Protein kinase-like (PK-like)	C2 domain (Calcium/lipid-binding domain, CaLB)	18	10
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	18	4
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	18	1
GroEL equatorial domain-like	GroEL apical domain-like	18	3
FYVE/PHD zinc finger	Bromodomain	18	13
LDL receptor-like module	Growth factor receptor domain	18	17
Metalloproteases ("zincins"), catalytic domain	Blood coagulation inhibitor (disintegrin)	18	2
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	18	2
POZ domain	Voltage-gated potassium channels	18	3
Growth factor receptor domain	Protein kinase-like (PK-like)	18	7
DPY module	DPY module	17	17
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	17	7
cAMP-binding domain-like	cAMP-binding domain-like	17	6
LDL receptor-like module	EGF/Laminin	17	17
Voltage-gated potassium channels	Periplasmic binding protein-like II	17	5
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	17	1
GroEL equatorial domain-like	GroEL-intermediate domain like	17	2
GroEL-intermediate domain like	GroEL apical domain-like	17	2
EGF/Laminin	YWTD domain	17	14
Sema domain	Plexin repeat	17	7
Protease propeptides/inhibitors	Zn-dependent exopeptidases	17	1
SH3-domain	PH domain-like	17	10
YWTD domain	YWTD domain	16	12
E set domains	Terpenoid cyclases/Protein prenyltransferases	16	1
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	16	4
LDL receptor-like module	YWTD domain	16	15
CoA-dependent acyltransferases	CoA-dependent acyltransferases	16	2
Growth factor receptor domain	Concanavalin A-like lectins/glucanases	16	16
GAF domain-like	HD-domain/PDEase-like	16	5
Spectrin repeat	PH domain-like	16	10
Immunoglobulin	Protein kinase-like (PK-like)	16	13
Calponin-homology domain, CH-domain	PH domain-like	16	8
E set domains	Alpha-macroglobulin receptor domain	16	1
L domain-like	Toll/Interleukin receptor TIR domain	15	12
YWTD domain	Growth factor receptor domain	15	14
ACT-like	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	15	2
PH domain-like	SH2 domain	15	6
Spermadhesin, CUB domain	EGF/Laminin	15	9
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	15	5
Periplasmic binding protein-like I	Voltage-gated potassium channels	15	3
PAZ domain	Ribonuclease H-like	14	4
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	14	4
PH domain-like	Protein kinase-like (PK-like)	14	6
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	14	3
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	14	11
Protein kinase-like (PK-like)	Nucleotide cyclase	14	5
Thiolase-like	Thiolase-like	14	4
EF-hand	PLC-like phosphodiesterases	14	7
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	14	6
Translation proteins	Ribosomal protein S5 domain 2-like	14	4
Immunoglobulin	TSP-1 type 1 repeat	14	8
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	14	2
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	14	6
NAD(P)-binding Rossmann-fold domains	Formate/glycerate dehydrogenase catalytic domain-like	14	6
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	14	3
L domain-like	Immunoglobulin	14	9
Myosin rod fragments	Myosin rod fragments	13	6
L domain-like	Protein kinase-like (PK-like)	13	6
Cadherin-like	EGF/Laminin	13	8
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex, superhelical domain	13	4
Ligand-binding domain in the NO signalling and Golgi transport	Nucleotide cyclase	13	1
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	13	7
"Winged helix" DNA-binding domain	Periplasmic binding protein-like II	13	1
PreATP-grasp domain	Rudiment single hybrid motif	13	5
Growth factor receptor domain	DPY module	13	13
Trypsin-like serine proteases	Trypsin-like serine proteases	12	3
BAR/IMD domain-like	GTPase activation domain, GAP	12	5
Cysteine-rich domain	Cysteine-rich domain	12	6
TSP-1 type 1 repeat	BPTI-like	12	7
RING/U-box	B-box zinc-binding domain	12	6
GAF domain-like	GAF domain-like	12	3
PH domain-like	PLC-like phosphodiesterases	12	5
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	12	7
PH domain-like	EF-hand	12	5
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	12	6
Thioredoxin-like	Thioredoxin-like	12	5
FnI-like domain	FnI-like domain	12	10
SMAD MH1 domain	SMAD/FHA domain	12	2
Fibronectin type III	(Phosphotyrosine protein) phosphatases II	12	8
Growth factor receptor domain	Fibronectin type III	12	4
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	12	2
Galactose-binding domain-like	Protein kinase-like (PK-like)	12	4
Cysteine-rich domain	Protein kinase-like (PK-like)	11	4
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	11	5
RuvA domain 2-like	RuvA domain 2-like	11	4
Tex N-terminal region-like	Nucleic acid-binding proteins	11	4
Plexin repeat	E set domains	11	2
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	11	2
Ribonuclease H-like	Nucleic acid-binding proteins	11	4
Sema domain	E set domains	11	2
Single hybrid motif	CoA-dependent acyltransferases	11	4
PH domain-like	(Phosphotyrosine protein) phosphatases II	11	7
WD40 repeat-like	RING/U-box	11	3
DBL homology domain (DH-domain)	SH3-domain	11	7
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	11	1
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	11	2
Protein kinase-like (PK-like)	P-loop containing nucleoside triphosphate hydrolases	11	4
E set domains	GTPase activation domain, GAP	11	2
RING/U-box	RING/U-box	11	7
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	11	2
Tudor/PWWP/MBT	Tudor/PWWP/MBT	11	8
Tex N-terminal region-like	RuvA domain 2-like	11	4
RuvA domain 2-like	Nucleic acid-binding proteins	11	4
Ribonuclease H-like	RuvA domain 2-like	11	4
Plexin repeat	GTPase activation domain, GAP	11	2
L domain-like	Growth factor receptor domain	11	4
Sema domain	GTPase activation domain, GAP	11	2
Immunoglobulin	(Phosphotyrosine protein) phosphatases II	11	7
Snake toxin-like	Protein kinase-like (PK-like)	11	3
Spermadhesin, CUB domain	LDL receptor-like module	11	10
Tex N-terminal region-like	Ribonuclease H-like	11	4
Cytochrome P450	Cytochrome P450	11	4
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	11	4
C2 domain (Calcium/lipid-binding domain, CaLB)	C-terminal domain of PLC-beta	10	4
Ribonuclease H-like	DNA/RNA polymerases	10	3
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	10	3
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	10	4
dsRNA-binding domain-like	dsRNA-binding domain-like	10	6
MFS general substrate transporter	MFS general substrate transporter	10	4
Ubiquitin-like	Protein kinase-like (PK-like)	10	4
PreATP-grasp domain	PreATP-grasp domain	10	3
SH3-domain	Protein kinase-like (PK-like)	10	5
PreATP-grasp domain	Methylglyoxal synthase-like	10	3
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	10	3
Di-copper centre-containing domain	E set domains	10	5
Chromo domain-like	Chromo domain-like	10	3
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	10	6
Cysteine proteinases	EF-hand	10	1
Calpain large subunit, middle domain (domain III)	EF-hand	10	1
Cap-Gly domain	Cap-Gly domain	10	4
WW domain	FF domain	10	4
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	10	3
RING/U-box	Cysteine proteinases	10	4
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	10	3
Complement control module/SCR domain	Complement control module/SCR domain	10	9
lambda repressor-like DNA-binding domains	Homeodomain-like	10	4
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	10	3
SAM/Pointed domain	"Winged helix" DNA-binding domain	10	2
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	10	3
Periplasmic binding protein-like I	Nucleotide cyclase	10	3
SAM/Pointed domain	SAM/Pointed domain	10	4
FF domain	FF domain	10	4
PYP-like sensor domain (PAS domain)	Voltage-gated potassium channels	10	3
ARM repeat	Clathrin adaptor appendage domain	10	3
Periplasmic binding protein-like I	Protein kinase-like (PK-like)	10	3
Cysteine-rich domain	PH domain-like	10	4
SH2 domain	SH2 domain	10	6
DNA breaking-rejoining enzymes	Eukaryotic DNA topoisomerase I, dispensable insert domain	9	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	9	4
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	9	3
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, dispensable insert domain	9	2
PH domain-like	C-terminal domain of PLC-beta	9	3
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	9	5
Hemocyanin, N-terminal domain	E set domains	9	4
TPR-like	Chaperone J-domain	9	2
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	9	3
FYVE/PHD zinc finger	Tudor/PWWP/MBT	9	6
PLC-like phosphodiesterases	C-terminal domain of PLC-beta	9	3
Cullin homology domain	"Winged helix" DNA-binding domain	9	3
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	9	4
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	9	7
Initiation factor IF2/eIF5b, domain 3	Translation proteins	9	2
(Trans)glycosidases	Glycosyl hydrolase domain	9	4
Resolvase-like	Homeodomain-like	9	1
Subtilisin-like	Growth factor receptor domain	9	4
EF-hand	C-terminal domain of PLC-beta	9	3
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	9	1
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	9	2
GTPase activation domain, GAP	SH3-domain	9	4
P-loop containing nucleoside triphosphate hydrolases	PH domain-like	9	6
"Winged helix" DNA-binding domain	Chorismate lyase-like	9	1
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	9	2
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	9	2
PYP-like sensor domain (PAS domain)	cAMP-binding domain-like	9	2
Hemocyanin, N-terminal domain	Di-copper centre-containing domain	9	4
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	9	4
PDZ domain-like	PH domain-like	9	5
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	9	3
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	9	1
Integrin domains	Integrin domains	9	5
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	8	3
EGF/Laminin	TB module/8-cys domain	8	8
Thiolase-like	ACP-like	8	2
P-loop containing nucleoside triphosphate hydrolases	Myosin rod fragments	8	1
PH domain-like	Ras GEF	8	5
Probable ACP-binding domain of malonyl-CoA ACP transacylase	alpha/beta-Hydrolases	8	2
PurM N-terminal domain-like	PurM C-terminal domain-like	8	4
Concanavalin A-like lectins/glucanases	ARM repeat	8	3
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8	2
NAD(P)-binding Rossmann-fold domains	ACP-like	8	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	8	1
cAMP-binding domain-like	Protein kinase-like (PK-like)	8	1
Calponin-homology domain, CH-domain	E set domains	8	6
PHM/PNGase F	PHM/PNGase F	8	3
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	8	6
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	8	2
Thiolase-like	GroES-like	8	2
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	8	6
Probable ACP-binding domain of malonyl-CoA ACP transacylase	NAD(P)-binding Rossmann-fold domains	8	2
Zn-finger domain of Sec23/24	vWA-like	8	3
MIR domain	MIR domain	8	3
Zn-finger domain of Sec23/24	beta-sandwich domain of Sec23/24	8	3
MIR domain	EF-hand	8	3
FabD/lysophospholipase-like	ACP-like	8	2
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8	2
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	8	2
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	8	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	8	1
MIR domain	IP3 receptor type 1 binding core, domain 2	8	3
Probable ACP-binding domain of malonyl-CoA ACP transacylase	GroES-like	8	2
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	8	4
BRCT domain	BRCT domain	8	7
Thiolase-like	alpha/beta-Hydrolases	8	2
Thiolase-like	NAD(P)-binding Rossmann-fold domains	8	2
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	8	2
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	8	2
Ras GEF	Ubiquitin-like	8	4
FabD/lysophospholipase-like	NAD(P)-binding Rossmann-fold domains	8	2
Concanavalin A-like lectins/glucanases	IP3 receptor type 1 binding core, domain 2	8	3
beta-sandwich domain of Sec23/24	vWA-like	8	3
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	8	3
Concanavalin A-like lectins/glucanases	EF-hand	8	3
Thiolase-like	FabD/lysophospholipase-like	8	2
TB module/8-cys domain	Growth factor receptor domain	8	8
EF-hand	RING/U-box	8	2
FabD/lysophospholipase-like	GroES-like	8	2
HMA, heavy metal-associated domain	HAD-like	8	6
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	8	3
ACP-like	alpha/beta-Hydrolases	8	2
GroES-like	alpha/beta-Hydrolases	8	2
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	8	2
Integrin alpha N-terminal domain	Integrin domains	8	4
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	8	2
Kringle-like	Protein kinase-like (PK-like)	8	2
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	8	3
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	8	3
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	8	2
Aconitase iron-sulfur domain	LeuD/IlvD-like	8	2
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	8	2
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	8	6
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex; beta-sheet shell regions	8	3
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	8	2
WW domain	Hect, E3 ligase catalytic domain	8	5
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	8	2
ENTH/VHS domain	GAT-like domain	8	2
Transmembrane di-heme cytochromes	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8	1
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	8	4
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	8	2
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	8	2
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	8	2
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	8	3
POZ domain	POZ domain	8	5
Tropomyosin	Tropomyosin	8	7
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	8	3
C2 domain (Calcium/lipid-binding domain, CaLB)	WW domain	8	5
PH domain-like	GTPase activation domain, GAP	8	7
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	8	3
WD40 repeat-like	TPR-like	8	5
Ankyrin repeat	SAM/Pointed domain	8	3
NAD(P)-binding Rossmann-fold domains	alpha/beta-Hydrolases	8	2
MIR domain	Concanavalin A-like lectins/glucanases	8	3
FabD/lysophospholipase-like	alpha/beta-Hydrolases	8	2
alpha-catenin/vinculin-like	alpha-catenin/vinculin-like	8	6
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	8	2
TB module/8-cys domain	TB module/8-cys domain	8	8
IP3 receptor type 1 binding core, domain 2	EF-hand	8	3
ArfGap/RecO-like zinc finger	PH domain-like	8	5
Probable ACP-binding domain of malonyl-CoA ACP transacylase	ACP-like	8	2
GroES-like	ACP-like	8	2
DBL homology domain (DH-domain)	Ras GEF	8	5
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	7	1
Kazal-type serine protease inhibitors	EF-hand	7	5
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	7	3
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	7	2
UBA-like	Ubiquitin-like	7	4
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	7	1
FYVE/PHD zinc finger	SET domain	7	5
Actin depolymerizing proteins	Actin depolymerizing proteins	7	3
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	7	1
Galactose-binding domain-like	(Trans)glycosidases	7	4
NTF2-like	UBA-like	7	2
Calponin-homology domain, CH-domain	SH3-domain	7	3
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	7	3
Spermadhesin, CUB domain	Growth factor receptor domain	7	4
Sec63 N-terminal domain-like	E set domains	7	3
Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	7	3
C2 domain (Calcium/lipid-binding domain, CaLB)	Hect, E3 ligase catalytic domain	7	4
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	7	2
BAR/IMD domain-like	PH domain-like	7	4
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	7	2
Concanavalin A-like lectins/glucanases	P-loop containing nucleoside triphosphate hydrolases	7	5
HR1 repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	7	5
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	7	5
ADC-like	P-loop containing nucleoside triphosphate hydrolases	7	3
Acetyl-CoA synthetase-like	Acetyl-CoA synthetase-like	7	4
Concanavalin A-like lectins/glucanases	RING/U-box	7	3
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	7	2
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	7	3
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	7	2
P-loop containing nucleoside triphosphate hydrolases	EF-hand	7	3
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	7	2
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	7	5
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	7	1
HR1 repeat	HR1 repeat	7	5
L domain-like	NTF2-like	7	2
Myosin S1 fragment, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	7	1
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	7	3
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	7	3
(Trans)glycosidases	(Trans)glycosidases	7	6
Glucocorticoid receptor-like (DNA-binding domain)	beta-beta-alpha zinc fingers	7	3
vWA-like	Helical domain of Sec23/24	7	2
Chitinase insertion domain	Chitinase insertion domain	7	6
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	7	2
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	7	1
HR1 repeat	Protein kinase-like (PK-like)	7	5
RING/U-box	CCCH zinc finger	7	3
PDZ domain-like	Ubiquitin-like	7	4
L domain-like	UBA-like	7	2
Galactose oxidase, central domain	POZ domain	7	6
ADC-like	Cdc48 domain 2-like	7	3
C2 domain (Calcium/lipid-binding domain, CaLB)	GTPase activation domain, GAP	7	6
Quinoprotein alcohol dehydrogenase-like	WD40 repeat-like	7	5
Galactose-binding domain-like	Fibronectin type III	7	3
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	7	1
Periplasmic binding protein-like II	Periplasmic binding protein-like II	7	1
Nucleic acid-binding proteins	Nucleic acid-binding proteins	7	4
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	7	1
DNA clamp	DNA clamp	7	1
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	6	2
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	6	1
Myosin rod fragments	Tropomyosin	6	6
ENTH/VHS domain	Clathrin adaptor appendage domain	6	1
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	6	2
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	6	3
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	6	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	6	2
C2 domain (Calcium/lipid-binding domain, CaLB)	Ubiquitin-like	6	3
vWA-like	EGF/Laminin	6	3
Clavaminate synthase-like	FYVE/PHD zinc finger	6	4
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	6	4
GAT-like domain	Clathrin adaptor appendage domain	6	1
Galactose-binding domain-like	Concanavalin A-like lectins/glucanases	6	4
CalX-like	CalX-like	6	1
ArfGap/RecO-like zinc finger	Ankyrin repeat	6	3
RNA-binding domain, RBD	SPOC domain-like	6	3
Class I glutamine amidotransferase-like	Carbamoyl phosphate synthetase, large subunit connection domain	6	2
PreATP-grasp domain	PurM N-terminal domain-like	6	2
BAR/IMD domain-like	Ankyrin repeat	6	3
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	6	4
EF-hand	Ferredoxin reductase-like, C-terminal NADP-linked domain	6	3
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	6	2
YjgF-like	YjgF-like	6	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	PreATP-grasp domain	6	2
EF-hand	Riboflavin synthase domain-like	6	3
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	6	3
TPR-like	RING/U-box	6	2
F-box domain	WD40 repeat-like	6	3
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	6	3
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	6	2
Nucleotidylyl transferase	Alpha-L RNA-binding motif	6	1
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	6	3
P-loop containing nucleoside triphosphate hydrolases	PUA domain-like	6	2
Protease propeptides/inhibitors	Galactose-binding domain-like	6	1
Metalloproteases ("zincins"), catalytic domain	Spermadhesin, CUB domain	6	4
Glutathione synthetase ATP-binding domain-like	PurM C-terminal domain-like	6	2
PH domain-like	Ankyrin repeat	6	3
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	6	2
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	6	2
Class II aaRS and biotin synthetases	ThrRS/AlaRS common domain	6	3
CCCH zinc finger	CCCH zinc finger	6	5
Protease propeptides/inhibitors	Subtilisin-like	6	1
Class I glutamine amidotransferase-like	Glutathione synthetase ATP-binding domain-like	6	2
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	6	2
ARM repeat	Subdomain of clathrin and coatomer appendage domain	6	2
Bromodomain	Tudor/PWWP/MBT	6	3
SH2 domain	SOCS box-like	6	2
RuvA domain 2-like	SH2 domain	6	3
Enolase N-terminal domain-like	Enolase C-terminal domain-like	6	1
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	6	4
Class I glutamine amidotransferase-like	PreATP-grasp domain	6	2
Tex N-terminal region-like	SH2 domain	6	3
BPTI-like	BPTI-like	6	6
Spectrin repeat	EF-hand	6	4
Invertebrate chitin-binding proteins	LDL receptor-like module	6	4
Phospholipase D/nuclease	Phospholipase D/nuclease	6	3
Glutathione synthetase ATP-binding domain-like	PurM N-terminal domain-like	6	2
Cysteine-rich domain	Ubiquitin-like	6	3
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	6	3
PUA domain-like	RING/U-box	6	5
Nucleic acid-binding proteins	SH2 domain	6	3
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	6	3
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	6	3
Adenine nucleotide alpha hydrolases-like	YjgF-like	6	3
Ribonuclease H-like	SH2 domain	6	3
Rudiment single hybrid motif	PurM C-terminal domain-like	6	2
PreATP-grasp domain	PurM C-terminal domain-like	6	2
Calponin-homology domain, CH-domain	EF-hand	6	3
Family A G protein-coupled receptor-like	Family A G protein-coupled receptor-like	6	2
RNA-binding domain, RBD	UBA-like	6	3
Surp module (SWAP domain)	Surp module (SWAP domain)	6	3
PR-1-like	Crisp domain-like	6	2
Rudiment single hybrid motif	PurM N-terminal domain-like	6	2
C2 domain (Calcium/lipid-binding domain, CaLB)	ARM repeat	6	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Methylglyoxal synthase-like	6	2
GTPase activation domain, GAP	RGC domain-like	6	2
(Trans)glycosidases	Six-hairpin glycosidases	6	1
Rudiment single hybrid motif	Single hybrid motif	6	2
LDL receptor-like module	Concanavalin A-like lectins/glucanases	6	6
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Carbamoyl phosphate synthetase, large subunit connection domain	6	2
B-box zinc-binding domain	NHL repeat	6	3
PreATP-grasp domain	Single hybrid motif	6	2
L domain-like	Family A G protein-coupled receptor-like	6	6
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Glutathione synthetase ATP-binding domain-like	6	2
RING/U-box	Homeodomain-like	6	4
Composite domain of metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	5	1
HIT/MYND zinc finger-like	SET domain	5	3
Immunoglobulin	EGF/Laminin	5	5
NAD(P)-binding Rossmann-fold domains	SCP-like	5	2
SNARE-like	SNARE fusion complex	5	2
Kazal-type serine protease inhibitors	Kazal-type serine protease inhibitors	5	4
Integrin domains	EGF/Laminin	5	2
EGF/Laminin	Integrin beta tail domain	5	2
Kelch motif	Kelch motif	5	2
CBS-domain pair	CBS-domain pair	5	1
Class I glutamine amidotransferase-like	Metallo-dependent hydrolases	5	1
PH domain-like	WD40 repeat-like	5	2
LDL receptor-like module	Immunoglobulin	5	5
Bromodomain	Bromodomain	5	3
Second domain of FERM	Protein kinase-like (PK-like)	5	3
CRAL/TRIO domain	Spectrin repeat	5	3
SRCR-like	Trypsin-like serine proteases	5	5
Methylglyoxal synthase-like	Metallo-dependent hydrolases	5	1
GTPase activation domain, GAP	Bet v1-like	5	1
PreATP-grasp domain	Aspartate/ornithine carbamoyltransferase	5	1
vWA-like	Integrin beta tail domain	5	2
vWA-like	Integrin domains	5	2
BRCT domain	DBL homology domain (DH-domain)	5	4
Glutathione synthetase ATP-binding domain-like	Metallo-dependent hydrolases	5	1
Glutathione synthetase ATP-binding domain-like	Aspartate/ornithine carbamoyltransferase	5	1
P-loop containing nucleoside triphosphate hydrolases	Retrovirus zinc finger-like domains	5	2
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	5	3
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	5	1
BRK domain-like	P-loop containing nucleoside triphosphate hydrolases	5	1
Growth factor receptor domain	Notch domain	5	5
PH domain-like	Phospholipase D/nuclease	5	2
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	5	2
DUSP-like	DUSP-like	5	1
Methylglyoxal synthase-like	Aspartate/ornithine carbamoyltransferase	5	1
L domain-like	Fibronectin type III	5	1
EGF/Laminin	Carboxypeptidase regulatory domain-like	5	1
Cyclophilin-like	TPR-like	5	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Composite domain of metallo-dependent hydrolases	5	1
B-box zinc-binding domain	Concanavalin A-like lectins/glucanases	5	1
Class I glutamine amidotransferase-like	Composite domain of metallo-dependent hydrolases	5	1
Class I glutamine amidotransferase-like	Aspartate/ornithine carbamoyltransferase	5	1
EGF/Laminin	DPY module	5	5
PreATP-grasp domain	Composite domain of metallo-dependent hydrolases	5	1
HIT/MYND zinc finger-like	TPR-like	5	3
PYP-like sensor domain (PAS domain)	HD-domain/PDEase-like	5	1
Carbamoyl phosphate synthetase, large subunit connection domain	Metallo-dependent hydrolases	5	1
DBL homology domain (DH-domain)	SH2 domain	5	1
Complement control module/SCR domain	Galactose-binding domain-like	5	5
RING/U-box	Fibronectin type III	5	1
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	5	2
Integrin domains	Integrin beta tail domain	5	2
Carbamoyl phosphate synthetase, large subunit connection domain	Composite domain of metallo-dependent hydrolases	5	1
Protein kinase-like (PK-like)	PDZ domain-like	5	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Aspartate/ornithine carbamoyltransferase	5	1
Carbamoyl phosphate synthetase, large subunit connection domain	Aspartate/ornithine carbamoyltransferase	5	1
ARM repeat	WD40 repeat-like	5	3
Cullin repeat-like	Cullin homology domain	5	2
TGS-like	Class II aaRS and biotin synthetases	5	2
BRK domain-like	Bromodomain	5	1
P-loop containing nucleoside triphosphate hydrolases	dsRNA-binding domain-like	5	3
EGF/Laminin	Notch domain	5	5
Chaperone J-domain	Homeodomain-like	5	1
Second domain of FERM	FAT domain of focal adhesion kinase	5	3
EGF/Laminin	Ankyrin repeat	5	5
TGS-like	Class II aaRS ABD-related	5	2
Notch domain	Ankyrin repeat	5	5
PX domain	Phospholipase D/nuclease	5	2
Notch domain	Notch domain	5	5
P-loop containing nucleoside triphosphate hydrolases	Ankyrin repeat	5	4
CCHHC domain	Acyl-CoA N-acyltransferases (Nat)	5	2
RING/U-box	TRAF domain-like	5	3
ARM repeat	Hect, E3 ligase catalytic domain	5	2
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	5	1
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	5	3
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	5	2
ARID-like	Clavaminate synthase-like	5	3
PreATP-grasp domain	Metallo-dependent hydrolases	5	1
RING/U-box	DUSP-like	5	1
Spectrin repeat	SH3-domain	5	5
A DNA-binding domain in eukaryotic transcription factors	Leucine zipper domain	5	4
PH domain-like	BEACH domain	5	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Metallo-dependent hydrolases	5	1
Methylglyoxal synthase-like	Composite domain of metallo-dependent hydrolases	5	1
p53-like transcription factors	E set domains	5	3
TGS-like	ThrRS/AlaRS common domain	5	2
FAS1 domain	FAS1 domain	5	3
Glutathione synthetase ATP-binding domain-like	Composite domain of metallo-dependent hydrolases	5	1
FYVE/PHD zinc finger	Chromo domain-like	5	1
Calponin-homology domain, CH-domain	DBL homology domain (DH-domain)	5	1
EGF/Laminin	Calcium-dependent phosphotriesterase	5	1
Protein kinase-like (PK-like)	FAT domain of focal adhesion kinase	5	3
C2 domain (Calcium/lipid-binding domain, CaLB)	Chaperone J-domain	5	3
P-loop containing nucleoside triphosphate hydrolases	GTPase activation domain, GAP	5	2
(Phosphotyrosine protein) phosphatases II	Chaperone J-domain	5	3
Growth factor receptor domain	Complement control module/SCR domain	5	5
Galactose-binding domain-like	Galactose-binding domain-like	5	5
Zn-dependent exopeptidases	Zn-dependent exopeptidases	5	3
LDL receptor-like module	Trypsin-like serine proteases	5	5
SMAD/FHA domain	P-loop containing nucleoside triphosphate hydrolases	5	4
B-box zinc-binding domain	Fibronectin type III	5	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	5	1
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	5	2
Carboxypeptidase regulatory domain-like	Calcium-dependent phosphotriesterase	5	1
Bet v1-like	HAD-like	5	1
Growth factor receptor domain	Ankyrin repeat	5	5
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	5	3
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	5	2
Calponin-homology domain, CH-domain	SH2 domain	5	1
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	5	2
Spectrin repeat	DBL homology domain (DH-domain)	5	3
PH domain-like	FAT domain of focal adhesion kinase	5	3
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	5	3
Sec7 domain	PH domain-like	5	2
Metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	5	1
P-loop containing nucleoside triphosphate hydrolases	Quinoprotein alcohol dehydrogenase-like	5	3
SET domain	TPR-like	5	3
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	5	2
Immunoglobulin	Growth factor receptor domain	5	5
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	5	3
Fibronectin type III	Concanavalin A-like lectins/glucanases	5	1
Ankyrin repeat	POZ domain	5	3
Cysteine proteinases	DUSP-like	5	1
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	cAMP-binding domain-like	5	2
CRAL/TRIO domain	PH domain-like	5	3
lambda repressor-like DNA-binding domains	LexA/Signal peptidase	5	1
PX domain	PH domain-like	5	2
CRAL/TRIO domain	DBL homology domain (DH-domain)	5	3
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	5	1
Tudor/PWWP/MBT	SAM/Pointed domain	5	3
SH3-domain	EF-hand	5	4
ThrRS/AlaRS common domain	Class II aaRS ABD-related	5	2
RNA-binding domain, RBD	PWI domain	4	1
Regulator of G-protein signaling, RGS	Protein kinase-like (PK-like)	4	1
Elafin-like	Immunoglobulin	4	4
Metalloproteases ("zincins"), catalytic domain	EGF/Laminin	4	2
alpha-helical ferredoxin	Nucleotide-binding domain	4	2
RNase III domain-like	RNase III domain-like	4	3
MgtE membrane domain-like	MgtE membrane domain-like	4	1
"Winged helix" DNA-binding domain	E set domains	4	2
L27 domain	PDZ domain-like	4	3
Protein kinase-like (PK-like)	(Phosphotyrosine protein) phosphatases II	4	2
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	4	3
PDZ domain-like	Glucocorticoid receptor-like (DNA-binding domain)	4	2
Transglutaminase, two C-terminal domains	Transglutaminase, two C-terminal domains	4	3
PreATP-grasp domain	Aldolase	4	1
L domain-like	P-loop containing nucleoside triphosphate hydrolases	4	4
Ubiquitin-like	RNA-binding domain, RBD	4	2
S15/NS1 RNA-binding domain	C-terminal domain of ProRS	4	2
SH2 domain	GTPase activation domain, GAP	4	2
BPTI-like	Elafin-like	4	4
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	4	1
Aldolase	Single hybrid motif	4	1
RNA-binding domain, RBD	Ran binding protein zinc finger-like	4	1
Calponin-homology domain, CH-domain	Calponin-homology domain, CH-domain	4	3
(Phosphotyrosine protein) phosphatases II	DNA ligase/mRNA capping enzyme, catalytic domain	4	1
Cysteine proteinases	Transglutaminase, two C-terminal domains	4	3
P-loop containing nucleoside triphosphate hydrolases	TGS-like	4	1
WD40 repeat-like	SNARE fusion complex	4	2
ARID-like	FYVE/PHD zinc finger	4	2
Bromodomain	HIT/MYND zinc finger-like	4	2
RNA-binding domain, RBD	L domain-like	4	1
Ubiquitin-like	ARM repeat	4	1
Histone-fold	PH domain-like	4	4
FYVE/PHD zinc finger	HIT/MYND zinc finger-like	4	2
FF domain	GTPase activation domain, GAP	4	1
GST C-terminal domain-like	Nucleotidylyl transferase	4	2
RNA-binding domain, RBD	NAD kinase/diacylglycerol kinase-like	4	2
Ankyrin repeat	Mib/herc2 domain-like	4	2
Ubiquitin-like	FAT domain of focal adhesion kinase	4	2
RNase III domain-like	dsRNA-binding domain-like	4	3
NAD kinase/diacylglycerol kinase-like	Ankyrin repeat	4	2
Rudiment single hybrid motif	post-HMGL domain-like	4	1
LDL receptor-like module	Mannose 6-phosphate receptor domain	4	2
DBL homology domain (DH-domain)	C2 domain (Calcium/lipid-binding domain, CaLB)	4	2
Thioredoxin-like	Six-hairpin glycosidases	4	1
RCC1/BLIP-II	Hect, E3 ligase catalytic domain	4	1
Protein kinase-like (PK-like)	Chaperone J-domain	4	2
GFP-like	YWTD domain	4	4
PH domain-like	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	4	3
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	4	1
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	4	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	4	2
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	4	2
Histone-fold	DBL homology domain (DH-domain)	4	4
Rhodanese/Cell cycle control phosphatase	(Phosphotyrosine protein) phosphatases II	4	1
Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	4	2
Galactose-binding domain-like	C-type lectin-like	4	4
Cyclophilin-like	RNA-binding domain, RBD	4	2
ARM repeat	P-loop containing nucleoside triphosphate hydrolases	4	1
ClpS-like	"Winged helix" DNA-binding domain	4	1
Glutathione synthetase ATP-binding domain-like	post-HMGL domain-like	4	1
HCP-like	HCP-like	4	3
PreATP-grasp domain	post-HMGL domain-like	4	1
lambda repressor-like DNA-binding domains	Periplasmic binding protein-like I	4	1
Complement control module/SCR domain	C-type lectin-like	4	4
Protein kinase-like (PK-like)	SAM/Pointed domain	4	2
TRAF domain-like	Cysteine proteinases	4	1
EGF/Laminin	Galactose-binding domain-like	4	4
Ubiquitin-like	NAD kinase/diacylglycerol kinase-like	4	2
Rudiment single hybrid motif	Aldolase	4	1
GST C-terminal domain-like	S15/NS1 RNA-binding domain	4	2
Concanavalin A-like lectins/glucanases	FnI-like domain	4	4
P-loop containing nucleoside triphosphate hydrolases	FF domain	4	1
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	4	1
Nucleic acid-binding proteins	Translation proteins SH3-like domain	4	2
PDZ domain-like	DBL homology domain (DH-domain)	4	3
PH domain-like	Moesin tail domain	4	2
PUA domain-like	Ribosomal protein S5 domain 2-like	4	1
SH3-domain	PX domain	4	3
PH domain-like	Oxysterol-binding protein-like	4	3
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	4	2
TAZ domain	Kix domain of CBP (creb binding protein)	4	4
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	4	3
DNA-binding domain	Bromodomain	4	3
SAP domain	Concanavalin A-like lectins/glucanases	4	2
P-loop containing nucleoside triphosphate hydrolases	POZ domain	4	2
Class II aaRS ABD-related	C-terminal domain of ProRS	4	2
PH domain-like	Ypt/Rab-GAP domain of gyp1p	4	3
Histone-fold	Ras GEF	4	4
EGF/Laminin	Complement control module/SCR domain	4	4
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	4	2
Glutathione synthetase ATP-binding domain-like	Aldolase	4	1
Carboxypeptidase regulatory domain-like	Carboxypeptidase regulatory domain-like	4	2
RNA-binding domain, RBD	NTF2-like	4	1
Formate/glycerate dehydrogenase catalytic domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	4	1
LDL receptor-like module	Glycoside hydrolase/deacetylase	4	2
post-HMGL domain-like	Single hybrid motif	4	1
GFP-like	Growth factor receptor domain	4	4
Metalloproteases ("zincins"), catalytic domain	Hemopexin-like domain	4	2
Regulator of G-protein signaling, RGS	PX domain	4	3
FKBP-like	TPR-like	4	2
Plexin repeat	vWA-like	4	2
DNA-binding domain	FYVE/PHD zinc finger	4	3
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	4	2
BPTI-like	Immunoglobulin	4	4
SAP domain	P-loop containing nucleoside triphosphate hydrolases	4	2
Clc chloride channel	CBS-domain pair	4	1
Cullin repeat-like	"Winged helix" DNA-binding domain	4	1
RUN domain-like	RUN domain-like	4	1
FnI-like domain	Growth factor receptor domain	4	4
Nucleotidylyl transferase	S15/NS1 RNA-binding domain	4	2
Aldolase	post-HMGL domain-like	4	1
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	4	2
Tudor/PWWP/MBT	HIT/MYND zinc finger-like	4	2
PH domain-like	ARM repeat	4	2
Invertebrate chitin-binding proteins	Glycoside hydrolase/deacetylase	4	2
Cysteine-rich domain	RNA-binding domain, RBD	4	2
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	4	2
Surp module (SWAP domain)	Ubiquitin-like	4	1
WW domain	PDZ domain-like	4	3
(Phosphotyrosine protein) phosphatases II	Nucleic acid-binding proteins	4	1
Starch-binding domain-like	Starch-binding domain-like	4	2
RUN domain-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	4	1
Chaperone J-domain	beta-beta-alpha zinc fingers	4	1
Second domain of FERM	Moesin tail domain	4	2
TSP-1 type 1 repeat	Elafin-like	4	4
ClpP/crotonase	ClpP/crotonase	4	2
P-loop containing nucleoside triphosphate hydrolases	E set domains	4	2
Kelch motif	Galactose oxidase, central domain	4	3
PAH2 domain	PAH2 domain	4	1
PGBD-like	Metalloproteases ("zincins"), catalytic domain	4	2
GST C-terminal domain-like	C-terminal domain of ProRS	3	1
MAST3 pre-PK domain-like	Protein kinase-like (PK-like)	3	1
GST C-terminal domain-like	Class II aaRS ABD-related	3	1
RNA-binding domain, RBD	Eukaryotic type KH-domain (KH-domain type I)	3	2
GTPase activation domain, GAP	CRAL/TRIO domain	3	3
EF-hand	Tropomyosin	3	1
Rudiment single hybrid motif	Formyltransferase	3	1
Regulator of G-protein signaling, RGS	Ubiquitin-like	3	3
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	3	1
Ribosomal protein L25-like	Class II aaRS and biotin synthetases	3	1
Outer arm dynein light chain 1	L domain-like	3	2
Protein kinase-like (PK-like)	Class II aaRS and biotin synthetases	3	1
Cna protein B-type domain	Starch-binding domain-like	3	1
B-box zinc-binding domain	FYVE/PHD zinc finger	3	2
LDL receptor-like module	SRCR-like	3	3
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	3	1
A heparin-binding domain	Amyloid beta a4 protein copper binding domain (domain 2)	3	2
E set domains	Cysteine proteinases	3	2
WD40 repeat-like	Ribonuclease H-like	3	2
Thioredoxin-like	eEF1-gamma domain	3	1
Transcription factor STAT-4 N-domain	p53-like transcription factors	3	1
GroEL apical domain-like	SAICAR synthase-like	3	2
GroES-like	GroES-like	3	1
Amyloid beta a4 protein copper binding domain (domain 2)	CAPPD, an extracellular domain of amyloid beta A4 protein	3	2
YVTN repeat-like/Quinoprotein amine dehydrogenase	Quinoprotein alcohol dehydrogenase-like	3	3
HSP20-like chaperones	TPR-like	3	1
SNF-like	SNF-like	3	1
Ribosomal protein L25-like	C-terminal domain of ProRS	3	1
Actin depolymerizing proteins	SH3-domain	3	1
A heparin-binding domain	CAPPD, an extracellular domain of amyloid beta A4 protein	3	2
P-loop containing nucleoside triphosphate hydrolases	Second domain of FERM	3	3
Ankyrin repeat	RING/U-box	3	2
E set domains	Transglutaminase, two C-terminal domains	3	2
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	3	1
Kelch motif	Fibronectin type III	3	2
Glucocorticoid receptor-like (DNA-binding domain)	Putative DNA-binding domain	3	2
Transcription factor STAT-4 N-domain	SH2 domain	3	1
Kelch motif	EGF/Laminin	3	2
LDL receptor-like module	EF-hand	3	1
Intermediate filament protein, coiled coil region	Lamin A/C globular tail domain	3	1
TAFH domain-like	HIT/MYND zinc finger-like	3	2
GST C-terminal domain-like	Ribosomal protein L25-like	3	1
FMN-linked oxidoreductases	alpha-helical ferredoxin	3	1
Alpha subunit of glutamate synthase, C-terminal domain	Nucleotide-binding domain	3	1
Ubiquitin-like	Cysteine proteinases	3	2
PABC (PABP) domain	Hect, E3 ligase catalytic domain	3	2
Smc hinge domain	Tropomyosin	3	3
Protein kinase-like (PK-like)	Polo-box domain	3	2
PurM N-terminal domain-like	Formyltransferase	3	1
WD40 repeat-like	UBC-like	3	1
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	3	1
Transducin (heterotrimeric G protein), gamma chain	Regulator of G-protein signaling, RGS	3	3
PUA domain-like	SWIB/MDM2 domain	3	2
Flavoproteins	Riboflavin synthase domain-like	3	2
Tudor/PWWP/MBT	ARID-like	3	2
BEACH domain	WD40 repeat-like	3	1
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	3	3
B-box zinc-binding domain	Bromodomain	3	2
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	3	1
L domain-like	Heme-dependent peroxidases	3	2
"Winged helix" DNA-binding domain	FYVE/PHD zinc finger	3	2
Immunoglobulin	Concanavalin A-like lectins/glucanases	3	3
Nucleotidylyl transferase	C-terminal domain of ProRS	3	1
Spermadhesin, CUB domain	Trypsin-like serine proteases	3	1
p53-like transcription factors	SH2 domain	3	1
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	3	1
alpha/beta knot	Nucleic acid-binding proteins	3	2
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	3	1
Chaperone J-domain	E set domains	3	1
POZ domain	beta-beta-alpha zinc fingers	3	3
Ubiquitin-like	RING/U-box	3	2
Thyroglobulin type-1 domain	Thyroglobulin type-1 domain	3	3
P-loop containing nucleoside triphosphate hydrolases	vWA-like	3	2
ISP domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	3	1
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	3	1
TSP-1 type 1 repeat	DEATH domain	3	1
Nucleoside diphosphate kinase, NDK	Nucleoside diphosphate kinase, NDK	3	2
L27 domain	P-loop containing nucleoside triphosphate hydrolases	3	2
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	3	2
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	3	2
Ankyrin repeat	SET domain	3	1
Immunoglobulin	Heme-dependent peroxidases	3	2
ARM repeat	Ankyrin repeat	3	1
ISP domain	FAD/NAD(P)-binding domain	3	1
POZ domain	Skp1 dimerisation domain-like	3	1
PDZ domain-like	Ras GEF	3	2
L27 domain	SH3-domain	3	2
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	3	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	3	1
Ankyrin repeat	TPR-like	3	2
WD40 repeat-like	Cysteine proteinases	3	2
RING/U-box	Cyclophilin-like	3	3
DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	3	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	3	1
Kazal-type serine protease inhibitors	Thyroglobulin type-1 domain	3	3
Glucocorticoid receptor-like (DNA-binding domain)	VPS9 domain	3	2
Actin depolymerizing proteins	VHP, Villin headpiece domain	3	1
Succinyl-CoA synthetase domains	NAD(P)-binding Rossmann-fold domains	3	2
UDP-Glycosyltransferase/glycogen phosphorylase	HAD-like	3	1
WD40 repeat-like	Putative isomerase YbhE	3	3
Nucleotidylyl transferase	Ribosomal protein L25-like	3	1
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	3	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	VPS9 domain	3	2
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	3	2
Immunoglobulin	DEATH domain	3	1
beta-beta-alpha zinc fingers	WW domain	3	1
PH domain-like	BSD domain-like	3	1
Ankyrin repeat	ADP-ribosylation	3	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	3	1
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	3	1
S15/NS1 RNA-binding domain	S15/NS1 RNA-binding domain	3	1
GST C-terminal domain-like	eEF1-gamma domain	3	1
PreATP-grasp domain	Formyltransferase	3	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	3	2
cAMP-binding domain-like	PDZ domain-like	3	2
SMAD/FHA domain	PH domain-like	3	2
PK beta-barrel domain-like	PK C-terminal domain-like	3	2
Ankyrin repeat	Voltage-gated potassium channels	3	1
Leukotriene A4 hydrolase N-terminal domain	Leukotriene A4 hydrolase N-terminal domain	3	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Cysteine-rich domain	3	2
DEATH domain	Protein kinase-like (PK-like)	3	1
BSD domain-like	BSD domain-like	3	1
FYVE/PHD zinc finger	RING/U-box	3	2
PH domain-like	VPS9 domain	3	2
STAT	p53-like transcription factors	3	1
FnI-like domain	EGF/Laminin	3	3
TPR-like	PH domain-like	3	2
Voltage-gated potassium channels	E set domains	3	2
Acetyl-CoA synthetase-like	Quinoprotein alcohol dehydrogenase-like	3	1
RING/U-box	NHL repeat	3	2
EF-hand	Thyroglobulin type-1 domain	3	3
Chromo domain-like	SET domain	3	2
DPP6 N-terminal domain-like	Tubby C-terminal domain-like	3	2
UBA-like	Thioredoxin-like	3	2
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	3	2
Tudor/PWWP/MBT	SET domain	3	3
PH domain-like	Ran binding protein zinc finger-like	3	2
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	3	1
Ribosomal L27 protein-like	Nucleic acid-binding proteins	3	2
Ankyrin repeat	Hect, E3 ligase catalytic domain	3	1
EF-hand	Mitochondrial carrier	3	2
FMN-linked oxidoreductases	Nucleotide-binding domain	3	1
Ankyrin repeat	Protein kinase-like (PK-like)	3	3
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	3	2
Complement control module/SCR domain	Concanavalin A-like lectins/glucanases	3	3
Invasin/intimin cell-adhesion fragments	Invasin/intimin cell-adhesion fragments	3	1
Ribosomal protein L25-like	Class II aaRS ABD-related	3	1
cAMP-binding domain-like	Ubiquitin-like	3	2
Acetyl-CoA synthetase-like	ACP-like	3	2
NAD(P)-binding Rossmann-fold domains	P-loop containing nucleoside triphosphate hydrolases	3	2
Glutathione synthetase ATP-binding domain-like	Formyltransferase	3	1
Nucleotidylyl transferase	Class II aaRS and biotin synthetases	3	1
MAST3 pre-PK domain-like	PDZ domain-like	3	1
POZ domain	Homeodomain-like	3	2
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	3	2
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	3	2
FKBP-like	FKBP-like	3	1
Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	3	2
RCC1/BLIP-II	RCC1/BLIP-II	3	2
Transcription factor STAT-4 N-domain	STAT	3	1
Nucleotidylyl transferase	Class II aaRS ABD-related	3	1
PLP-dependent transferases	PLP-dependent transferases	3	2
Mib/herc2 domain-like	Hect, E3 ligase catalytic domain	3	1
Kringle-like	Kringle-like	3	2
PRP4-like	WD40 repeat-like	3	2
cAMP-binding domain-like	FabD/lysophospholipase-like	3	2
WD40 repeat-like	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	3	2
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	3	1
ARID-like	ARM repeat	3	2
CCCH zinc finger	RNA-binding domain, RBD	3	2
Chaperone J-domain	Sec63 N-terminal domain-like	3	1
SNARE fusion complex	SNARE fusion complex	3	1
Spermadhesin, CUB domain	Kelch motif	3	2
Guanido kinase N-terminal domain	Glutamine synthetase/guanido kinase	3	1
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	3	2
Methylated DNA-protein cysteine methyltransferase domain	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	3	1
Metalloproteases ("zincins"), catalytic domain	Metalloproteases ("zincins"), catalytic domain	3	1
Ribosomal protein L6	Ribosomal protein L6	3	1
PurM C-terminal domain-like	Formyltransferase	3	1
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	3	1
cAMP-binding domain-like	Ras GEF	3	2
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	3	1
CCCH zinc finger	Retrovirus zinc finger-like domains	3	2
EF-hand	Mannose 6-phosphate receptor domain	3	1
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	3	1
Clathrin heavy-chain terminal domain	ARM repeat	3	1
Ankyrin repeat	DEATH domain	3	1
Alpha subunit of glutamate synthase, C-terminal domain	alpha-helical ferredoxin	3	1
PGBD-like	Hemopexin-like domain	3	1
PH domain-like	Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	3	1
Putative DNA-binding domain	SAND domain-like	3	3
Ubiquitin-like	DBL homology domain (DH-domain)	3	3
Cysteine proteinases	Ribonuclease H-like	3	2
PDZ domain-like	(Phosphotyrosine protein) phosphatases II	3	2
Second domain of FERM	Second domain of FERM	3	3
GST C-terminal domain-like	Class II aaRS and biotin synthetases	3	1
Hairpin loop containing domain-like	Hairpin loop containing domain-like	3	2
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	3	2
Ribosomal protein L25-like	S15/NS1 RNA-binding domain	3	1
STAT	SH2 domain	3	1
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	3	2
SAM/Pointed domain	ADP-ribosylation	3	1
ARM repeat	Mib/herc2 domain-like	3	1
DEK C-terminal domain	SWIB/MDM2 domain	3	1
C-terminal UvrC-binding domain of UvrB	RuvA domain 2-like	3	1
Hermes dimerisation domain	Ribonuclease H-like	3	1
TPR-like	RNA-binding domain, RBD	2	1
FMT C-terminal domain-like	ALDH-like	2	1
RNA-binding domain, RBD	PABC (PABP) domain	2	1
Lipovitellin-phosvitin complex, superhelical domain	ARM repeat	2	1
IP3 receptor type 1 binding core, domain 2	ARM repeat	2	1
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	2	1
SAM/Pointed domain	PH domain-like	2	2
WWE domain	RING/U-box	2	2
TSP type-3 repeat	TSP type-3 repeat	2	2
PX domain	BAR/IMD domain-like	2	2
L domain-like	Calponin-homology domain, CH-domain	2	1
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	2	2
Nitrous oxide reductase, N-terminal domain	WD40 repeat-like	2	1
CBS-domain pair	cAMP-binding domain-like	2	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	2	1
Ubiquitin-like	FYVE/PHD zinc finger	2	1
Concanavalin A-like lectins/glucanases	BEACH domain	2	2
DNase I-like	DNA/RNA polymerases	2	1
PH domain-like	I/LWEQ domain	2	1
Thioredoxin-like	Ubiquitin-like	2	1
PX domain	Protein kinase-like (PK-like)	2	2
Second domain of FERM	DBL homology domain (DH-domain)	2	2
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	2	2
SWIB/MDM2 domain	eIF1-like	2	1
Kazal-type serine protease inhibitors	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	2	2
DBL homology domain (DH-domain)	WD40 repeat-like	2	1
GDNF receptor-like	GDNF receptor-like	2	2
GFP-like	EGF/Laminin	2	2
Ribonuclease H-like	HRDC-like	2	2
L domain-like	Concanavalin A-like lectins/glucanases	2	2
Spermadhesin, CUB domain	Complement control module/SCR domain	2	2
ARM repeat	Cysteine proteinases	2	1
Saposin	Metallo-dependent phosphatases	2	1
A middle domain of Talin 1	alpha-catenin/vinculin-like	2	1
RNA-binding domain, RBD	Class II aaRS ABD-related	2	2
LDL receptor-like module	Protein kinase-like (PK-like)	2	2
Concanavalin A-like lectins/glucanases	PH domain-like	2	2
Glutathione synthetase ATP-binding domain-like	NAD(P)-binding Rossmann-fold domains	2	1
Plexin repeat	Integrin domains	2	1
L domain-like	Actin depolymerizing proteins	2	1
ARM repeat	WWE domain	2	1
Surp module (SWAP domain)	ENTH/VHS domain	2	1
Growth factor receptor domain	SAM/Pointed domain	2	1
Ubiquitin-like	Zn-binding ribosomal proteins	2	1
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	1
ARM repeat	GTPase activation domain, GAP	2	2
TRAF domain-like	TRAF domain-like	2	2
ARM repeat	CRAL/TRIO domain	2	2
PAZ domain	dsRNA-binding domain-like	2	2
Ribosomal protein S5 domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	2	2
NAD kinase/diacylglycerol kinase-like	SAM/Pointed domain	2	1
Staphylococcal nuclease	Staphylococcal nuclease	2	2
Phenylalanine zipper	SH2 domain	2	1
FYVE/PHD zinc finger	PUA domain-like	2	1
Calponin-homology domain, CH-domain	Glucocorticoid receptor-like (DNA-binding domain)	2	1
PTS system IIB component-like	Phoshotransferase/anion transport protein	2	1
alpha/beta-Hydrolases	alpha/beta-Hydrolases	2	1
FYVE/PHD zinc finger	Elongation factor TFIIS domain 2	2	2
Quinoprotein alcohol dehydrogenase-like	Putative isomerase YbhE	2	2
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	2	1
Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	2	2
LDL receptor-like module	Galactose-binding domain-like	2	2
TATA-box binding protein-like	TATA-box binding protein-like	2	2
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	2	1
Kazal-type serine protease inhibitors	Immunoglobulin	2	1
FYVE/PHD zinc finger	S-adenosyl-L-methionine-dependent methyltransferases	2	2
t-snare proteins	SNARE fusion complex	2	2
Nqo1 middle domain-like	Nqo1C-terminal domain-like	2	1
EF-hand	Isochorismatase-like hydrolases	2	1
Serine protease inhibitors	FnI-like domain	2	2
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	2	2
YWTD domain	Protein kinase-like (PK-like)	2	1
DBL homology domain (DH-domain)	Quinoprotein alcohol dehydrogenase-like	2	1
PAZ domain	RNase III domain-like	2	2
WGR domain-like	Domain of poly(ADP-ribose) polymerase	2	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	2	1
Ubiquitin-like	(Phosphotyrosine protein) phosphatases II	2	1
Mib/herc2 domain-like	Mib/herc2 domain-like	2	2
BRCT domain	PH domain-like	2	2
L domain-like	EGF/Laminin	2	2
Fibronectin type III	SAM/Pointed domain	2	1
PX domain	MIT domain	2	2
WWE domain	Hect, E3 ligase catalytic domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Fzo-like conserved region	2	2
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	2	1
Heme-dependent peroxidases	EF-hand	2	1
beta-beta-alpha zinc fingers	Homeodomain-like	2	2
WD40 repeat-like	EF-hand	2	2
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	2	1
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	2	1
DNA-binding protein LAG-1 (CSL)	E set domains	2	2
GTPase activation domain, GAP	VPS9 domain	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	1
Thioesterase/thiol ester dehydrase-isomerase	SCP-like	2	1
Spermadhesin, CUB domain	Concanavalin A-like lectins/glucanases	2	2
Folate-binding domain	Aminomethyltransferase beta-barrel domain	2	1
E set domains	RING/U-box	2	1
PUA domain-like	Nucleotidylyl transferase	2	1
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	2	1
FAD/NAD(P)-binding domain	Calponin-homology domain, CH-domain	2	1
Immunoglobulin	Hormone receptor domain	2	2
Inosine monophosphate dehydrogenase (IMPDH)	Inosine monophosphate dehydrogenase (IMPDH)	2	2
Galactose-binding domain-like	BRCT domain	2	1
UBA-like	P-loop containing nucleoside triphosphate hydrolases	2	1
PH domain-like	alpha-catenin/vinculin-like	2	1
Doublecortin (DC)	POZ domain	2	1
Succinyl-CoA synthetase domains	Citrate synthase	2	1
DNase I-like	GTPase activation domain, GAP	2	2
Doublecortin (DC)	Pentapeptide repeat-like	2	1
Phenylalanine zipper	PH domain-like	2	1
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	2	2
I/LWEQ domain	I/LWEQ domain	2	1
ARM repeat	EF-hand	2	1
Plexin repeat	TSP-1 type 1 repeat	2	2
LDL receptor-like module	Terpenoid cyclases/Protein prenyltransferases	2	2
PIN domain-like	Nucleic acid-binding proteins	2	1
Galactose oxidase, central domain	Fibronectin type III	2	1
P-loop containing nucleoside triphosphate hydrolases	SOCS box-like	2	1
Rudiment single hybrid motif	ClpP/crotonase	2	1
DNA polymerase beta, N-terminal domain-like	Restriction endonuclease-like	2	1
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	2	1
BRCT domain	Domain of poly(ADP-ribose) polymerase	2	1
TPR-like	Ran binding protein zinc finger-like	2	1
lambda repressor-like DNA-binding domains	lambda repressor-like DNA-binding domains	2	1
Fibronectin type III	YWTD domain	2	1
Galactose-binding domain-like	SAM/Pointed domain	2	1
BRCA2 helical domain	Nucleic acid-binding proteins	2	2
Glutathione synthetase ATP-binding domain-like	Citrate synthase	2	1
PTS-regulatory domain, PRD	Phoshotransferase/anion transport protein	2	1
"Winged helix" DNA-binding domain	Transducin (heterotrimeric G protein), gamma chain	2	2
Ribosomal protein S5 domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	2	2
Methuselah ectodomain	Family A G protein-coupled receptor-like	2	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	2	2
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	2	1
I/LWEQ domain	alpha-catenin/vinculin-like	2	1
Sema domain	TSP-1 type 1 repeat	2	2
Putative isomerase YbhE	TPR-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Ubiquitin-like	2	2
Formyltransferase	FMT C-terminal domain-like	2	1
FAD/NAD(P)-binding domain	Glucocorticoid receptor-like (DNA-binding domain)	2	1
LDL receptor-like module	Family A G protein-coupled receptor-like	2	2
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	2	1
EF-hand	Cysteine-rich domain	2	2
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	2	2
TPR-like	Clavaminate synthase-like	2	1
Ankyrin repeat	FabD/lysophospholipase-like	2	2
P-loop containing nucleoside triphosphate hydrolases	MOP-like	2	1
Calponin-homology domain, CH-domain	GAS2 domain-like	2	1
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	2	1
DBL homology domain (DH-domain)	BAR/IMD domain-like	2	2
SH3-domain	ARM repeat	2	1
PX domain	Ubiquitin-like	2	1
PP2C-like	PP2C-like	2	1
Second domain of FERM	A middle domain of Talin 1	2	1
CCHHC domain	CCHHC domain	2	2
Taf5 N-terminal domain-like	WD40 repeat-like	2	1
FAD/NAD(P)-binding domain	EF-hand	2	2
Chaperone J-domain	RNA-binding domain, RBD	2	1
PH domain-like	Bet v1-like	2	1
LDL receptor-like module	Alpha-macroglobulin receptor domain	2	2
THUMP domain-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
MOSC N-terminal domain-like	PK beta-barrel domain-like	2	1
Ubiquitin-like	Ran binding protein zinc finger-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Nucleotidylyl transferase	2	1
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	2	2
Thioredoxin-like	ERP29 C domain-like	2	1
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	2	1
SRCR-like	SRCR-like	2	2
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	2	1
Plexin repeat	EGF/Laminin	2	1
TSP type-3 repeat	Concanavalin A-like lectins/glucanases	2	2
"Winged helix" DNA-binding domain	occludin/ELL-like	2	1
EF-hand	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	2	1
Carbamate kinase-like	ALDH-like	2	1
Cadherin-like	Growth factor receptor domain	2	2
Macro domain-like	Zn-dependent exopeptidases	2	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	2	1
LDL receptor-like module	Complement control module/SCR domain	2	2
UBA-like	NSFL1 (p97 ATPase) cofactor p47, SEP domain	2	1
RNA-binding domain, RBD	DPP6 N-terminal domain-like	2	1
Ribonuclease PH domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	2	2
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
FYVE/PHD zinc finger	GroEL apical domain-like	2	1
Staphylococcal nuclease	Tudor/PWWP/MBT	2	2
A middle domain of Talin 1	I/LWEQ domain	2	1
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	2	2
EF-hand	Immunoglobulin	2	1
Ubiquitin-like	Moesin tail domain	2	1
TrmE connector domain	P-loop containing nucleoside triphosphate hydrolases	2	2
Radical SAM enzymes	Molybdenum cofactor biosynthesis protein C, MoaC	2	1
NAD(P)-binding Rossmann-fold domains	Citrate synthase	2	1
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	2	1
PreATP-grasp domain	ClpP/crotonase	2	1
MIR domain	ARM repeat	2	1
E set domains	Galactose-binding domain-like	2	1
SEA domain	EGF/Laminin	2	1
P-loop containing nucleoside triphosphate hydrolases	RNase III domain-like	2	2
Heme-dependent peroxidases	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	1
HCP-like	Protein kinase-like (PK-like)	2	1
Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	2	2
Mib/herc2 domain-like	RING/U-box	2	2
SH3-domain	Fibronectin type III	2	1
FYVE/PHD zinc finger	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
FAD-linked reductases, C-terminal domain	EF-hand	2	2
"Winged helix" DNA-binding domain	Regulator of G-protein signaling, RGS	2	2
Eukaryotic type KH-domain (KH-domain type I)	Retrovirus zinc finger-like domains	2	1
CRAL/TRIO domain	(Phosphotyrosine protein) phosphatases II	2	2
Ankyrin repeat	FYVE/PHD zinc finger	2	1
RCC1/BLIP-II	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	2	2
Cysteine-rich domain	GTPase activation domain, GAP	2	2
Protein kinase-like (PK-like)	L27 domain	2	1
Immunoglobulin	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	1
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	2	1
E set domains	Ankyrin repeat	2	1
PDZ domain-like	BAR/IMD domain-like	2	1
Single hybrid motif	ClpP/crotonase	2	1
Spermadhesin, CUB domain	Galactose-binding domain-like	2	2
BRCT domain	Homeodomain-like	2	1
Hormone receptor domain	Family A G protein-coupled receptor-like	2	1
Ankyrin repeat	L domain-like	2	2
PLC-like phosphodiesterases	Ubiquitin-like	2	2
DNase I-like	RNA-binding domain, RBD	2	1
PDZ domain-like	PX domain	2	1
Heme-dependent peroxidases	Riboflavin synthase domain-like	2	1
C-type lectin-like	Immunoglobulin	2	1
ARM repeat	Rap/Ran-GAP	2	1
MIT domain	Protein kinase-like (PK-like)	2	2
Nucleotide-diphospho-sugar transferases	IpsF-like	2	1
Thiolase-like	SCP-like	2	1
DAK1/DegV-like	DhaL-like	2	1
Phosphofructokinase	Phosphofructokinase	2	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Eukaryotic type KH-domain (KH-domain type I)	2	2
Dcp2 domain-like	Nudix	2	1
CHY zinc finger-like	Zinc hairpin stack	2	1
Glucocorticoid receptor-like (DNA-binding domain)	VHP, Villin headpiece domain	2	2
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	2	1
PRTase-like	PRTase-like	2	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	2	1
E set domains	Hect, E3 ligase catalytic domain	2	2
Ubiquitin-like	PUA domain-like	2	1
RCC1/BLIP-II	PH domain-like	2	2
FMN-linked oxidoreductases	dsRNA-binding domain-like	2	1
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	2	1
Cytochrome b5-like heme/steroid binding domain	Riboflavin synthase domain-like	2	2
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	2	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	2	1
PH domain-like	Quinoprotein alcohol dehydrogenase-like	2	1
Plexin repeat	Immunoglobulin	2	1
P-loop containing nucleoside triphosphate hydrolases	PAZ domain	2	2
"Winged helix" DNA-binding domain	SAICAR synthase-like	2	1
C-type lectin-like	Fibronectin type III	2	1
LDL receptor-like module	L domain-like	2	2
Second domain of FERM	(Phosphotyrosine protein) phosphatases II	2	1
Zinc beta-ribbon	Cyclin-like	2	1
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	2	1
Second domain of FERM	PDZ domain-like	2	1
SH2 domain	Ras GEF	2	1
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	2	1
Glucocorticoid receptor-like (DNA-binding domain)	Ubiquitin-like	2	1
Galactose-binding domain-like	RING/U-box	2	1
Zinc beta-ribbon	Zinc beta-ribbon	2	1
B-box zinc-binding domain	TRAF domain-like	2	1
Tetrapyrrole methylase	S-adenosyl-L-methionine-dependent methyltransferases	2	1
HCP-like	SAM/Pointed domain	2	1
ISP transmembrane anchor	ISP domain	2	2
YVTN repeat-like/Quinoprotein amine dehydrogenase	WD40 repeat-like	2	2
Sema domain	Immunoglobulin	2	1
Acyl-CoA binding protein	Supernatant protein factor (SPF), C-terminal domain	2	2
BRCT domain	WGR domain-like	2	1
Tubulin nucleotide-binding domain-like	Tubulin nucleotide-binding domain-like	2	1
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	2	1
Formyltransferase	ALDH-like	2	1
Plexin repeat	Integrin beta tail domain	2	1
Hypothetical protein c14orf129, hspc210	TPR-like	2	1
POZ domain	FYVE/PHD zinc finger	2	1
PH domain-like	A middle domain of Talin 1	2	1
RING/U-box	RNA-binding domain, RBD	2	2
FYVE/PHD zinc finger	SAICAR synthase-like	2	1
Nucleotide cyclase	P-loop containing nucleoside triphosphate hydrolases	2	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	2	1
POZ domain	Pentapeptide repeat-like	2	1
Ankyrin repeat	SH3-domain	2	2
PUA domain-like	eIF1-like	2	1
PDZ domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
RUN domain-like	FYVE/PHD zinc finger	2	1
Myosin rod fragments	Mitotic arrest deficient-like 1, Mad1	2	2
Sec63 N-terminal domain-like	DNA/RNA polymerases	2	2
PTS-regulatory domain, PRD	PTS system IIB component-like	2	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	ARM repeat	2	1
NAD(P)-binding Rossmann-fold domains	Thioesterase/thiol ester dehydrase-isomerase	2	1
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	2	2
Second domain of FERM	I/LWEQ domain	2	1
RNI-like	Ubiquitin-like	2	1
WGR domain-like	ADP-ribosylation	2	1
BRCT domain	ADP-ribosylation	2	1
vWA-like	Complement control module/SCR domain	2	2
"Winged helix" DNA-binding domain	GroEL apical domain-like	2	1
GST C-terminal domain-like	eEF-1beta-like	2	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	2	1
Putative DNA-binding domain	Cation efflux protein transmembrane domain-like	2	1
Ankyrin repeat	PDZ domain-like	2	2
Heme-dependent peroxidases	Heme-dependent peroxidases	2	1
Cation efflux protein transmembrane domain-like	Cation efflux protein transmembrane domain-like	2	1
Second domain of FERM	alpha-catenin/vinculin-like	2	1
FAD-linked reductases, C-terminal domain	FAD-linked reductases, C-terminal domain	2	1
RAP domain-like	RAP domain-like	1	1
Nitric oxide (NO) synthase oxygenase domain	Flavoproteins	1	1
TAFH domain-like	Histone-fold	1	1
P-loop containing nucleoside triphosphate hydrolases	Putative isomerase YbhE	1	1
HR1 repeat	PDZ domain-like	1	1
Ras GEF	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
PurS-like	FGAM synthase PurL, linker domain	1	1
SET domain	WW domain	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
C-type lectin-like	LDL receptor-like module	1	1
POZ domain	Galactose-binding domain-like	1	1
F-box domain	Pectin lyase-like	1	1
ARID-like	Chromo domain-like	1	1
DNA-binding domain	SET domain	1	1
His-Me finger endonucleases	His-Me finger endonucleases	1	1
Methylglyoxal synthase-like	Cytidine deaminase-like	1	1
Pseudouridine synthase	(Phosphotyrosine protein) phosphatases II	1	1
Invertebrate chitin-binding proteins	Galactose-binding domain-like	1	1
HAD-like	P-loop containing nucleoside triphosphate hydrolases	1	1
GTPase activation domain, GAP	Ubiquitin-like	1	1
Uracil-DNA glycosylase-like	Cytidine deaminase-like	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	LDL receptor-like module	1	1
WD40 repeat-like	SAM/Pointed domain	1	1
B-box zinc-binding domain	P-loop containing nucleoside triphosphate hydrolases	1	1
WW domain	PH domain-like	1	1
p53-like transcription factors	DNA-binding protein LAG-1 (CSL)	1	1
FAD-linked reductases, C-terminal domain	MoaD/ThiS	1	1
Voltage-gated potassium channels	Small-conductance potassium channel	1	1
WD40 repeat-like	Galactose oxidase, central domain	1	1
SMAD/FHA domain	"Winged helix" DNA-binding domain	1	1
Cystatin/monellin	Cysteine proteinases	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	CCCH zinc finger	1	1
UBA-like	Phosphoglycerate mutase-like	1	1
Concanavalin A-like lectins/glucanases	Protein kinase-like (PK-like)	1	1
Quinoprotein alcohol dehydrogenase-like	Tricorn protease domain 2	1	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	1	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
Calcyclin-binding protein-like	HSP20-like chaperones	1	1
PH domain-like	Cullin repeat-like	1	1
"Winged helix" DNA-binding domain	Dimeric alpha+beta barrel	1	1
CoA-dependent acyltransferases	NAD(P)-binding Rossmann-fold domains	1	1
Cysteine proteinases	Cysteine proteinases	1	1
PH domain-like	FYVE/PHD zinc finger	1	1
Single hybrid motif	NAD(P)-binding Rossmann-fold domains	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ATP-dependent DNA ligase DNA-binding domain	1	1
Thyroglobulin type-1 domain	Leech antihemostatic proteins	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
Trypsin-like serine proteases	PDZ domain-like	1	1
C-type lectin-like	Concanavalin A-like lectins/glucanases	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
Nitric oxide (NO) synthase oxygenase domain	Riboflavin synthase domain-like	1	1
ENTH/VHS domain	RNA-binding domain, RBD	1	1
TPR-like	RNI-like	1	1
SMAD/FHA domain	HAD-like	1	1
Elafin-like	Fibronectin type III	1	1
SAM/Pointed domain	RING/U-box	1	1
Ras GEF	EF-hand	1	1
Regulator of G-protein signaling, RGS	PH domain-like	1	1
FYVE/PHD zinc finger	Acyl-CoA N-acyltransferases (Nat)	1	1
TRAF domain-like	POZ domain	1	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Nucleic acid-binding proteins	1	1
PDZ domain-like	Cysteine-rich domain	1	1
PH domain-like	HMG-box	1	1
SAND domain-like	HIT/MYND zinc finger-like	1	1
Protein kinase-like (PK-like)	KA1-like	1	1
Histone-fold	POZ domain	1	1
ARM repeat	SAM/Pointed domain	1	1
Actin-like ATPase domain	AF1104-like	1	1
P-loop containing nucleoside triphosphate hydrolases	SET domain	1	1
BPTI-like	Concanavalin A-like lectins/glucanases	1	1
PurS-like	PurM C-terminal domain-like	1	1
Translation proteins	ThrRS/AlaRS common domain	1	1
GST C-terminal domain-like	Methionyl-tRNA synthetase (MetRS), Zn-domain	1	1
Homeodomain-like	Bromodomain	1	1
Cystatin/monellin	Cystatin/monellin	1	1
PUG domain-like	Ubiquitin-like	1	1
Leech antihemostatic proteins	BPTI-like	1	1
Thiolase-like	Thioredoxin-like	1	1
GMP synthetase C-terminal dimerisation domain	GMP synthetase C-terminal dimerisation domain	1	1
E set domains	Complement control module/SCR domain	1	1
Bacterial hemolysins	Tropomyosin	1	1
ARM repeat	Thioesterase/thiol ester dehydrase-isomerase	1	1
RING/U-box	P-loop containing nucleoside triphosphate hydrolases	1	1
WWE domain	WWE domain	1	1
Invertebrate chitin-binding proteins	SRCR-like	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
EF-hand	NAD kinase/diacylglycerol kinase-like	1	1
RING/U-box	Bromodomain	1	1
C-type lectin-like	Spermadhesin, CUB domain	1	1
SH3-domain	Phosphoglycerate mutase-like	1	1
PKD domain	PKD domain	1	1
Quinoprotein alcohol dehydrogenase-like	F-box domain	1	1
L domain-like	PP2C-like	1	1
Cap-Gly domain	Cysteine proteinases	1	1
PDZ domain-like	Regulator of G-protein signaling, RGS	1	1
Arabinanase/levansucrase/invertase	Concanavalin A-like lectins/glucanases	1	1
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	1	1
SMAD/FHA domain	Protein kinase-like (PK-like)	1	1
Cadherin-like	Protein kinase-like (PK-like)	1	1
Homeodomain-like	SIS domain	1	1
HIT-like	HIT-like	1	1
Heat shock protein 70kD (HSP70), C-terminal subdomain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	1	1
CRAL/TRIO domain	SH3-domain	1	1
RNI-like	Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain	1	1
BRCA2 helical domain	BRCA2 tower domain	1	1
Ribosomal protein S5 domain 2-like	Nucleic acid-binding proteins	1	1
AMMECR1-like	AMMECR1-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheY-like	1	1
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
beta-beta-alpha zinc fingers	FYVE/PHD zinc finger	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
Eukaryotic type KH-domain (KH-domain type I)	P-loop containing nucleoside triphosphate hydrolases	1	1
a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	1	1
Frizzled cysteine-rich domain	LDL receptor-like module	1	1
TROVE domain-like	vWA-like	1	1
EGF/Laminin	TIMP-like	1	1
Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	1	1
PDZ domain-like	GTPase activation domain, GAP	1	1
Chaperone J-domain	Chaperone J-domain	1	1
GST C-terminal domain-like	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
PX domain	GTPase activation domain, GAP	1	1
EGF/Laminin	TSP type-3 repeat	1	1
Tricorn protease domain 2	EF-hand	1	1
Zinc beta-ribbon	YrdC/RibB	1	1
Sigma2 domain of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	1	1
Cysteine proteinases	UBA-like	1	1
RCC1/BLIP-II	VPS9 domain	1	1
FGAM synthase PurL, linker domain	PurM N-terminal domain-like	1	1
Elafin-like	Elafin-like	1	1
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	1	1
Homeodomain-like	Methylated DNA-protein cysteine methyltransferase domain	1	1
TPR-like	Metallo-dependent phosphatases	1	1
FKBP-like	EF-hand	1	1
Histone-fold	Ankyrin repeat	1	1
Rap/Ran-GAP	PDZ domain-like	1	1
Thyroglobulin type-1 domain	BPTI-like	1	1
Cytochrome b5-like heme/steroid binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
XPC-binding domain	UBA-like	1	1
UBA-like	SH3-domain	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	Methylated DNA-protein cysteine methyltransferase domain	1	1
Leech antihemostatic proteins	Leech antihemostatic proteins	1	1
VPS9 domain	Ubiquitin-like	1	1
FnI-like domain	Galactose-binding domain-like	1	1
Tudor/PWWP/MBT	Chromo domain-like	1	1
Apolipoprotein A-I	Apolipoprotein A-I	1	1
vWA-like	Concanavalin A-like lectins/glucanases	1	1
SH3-domain	SAM/Pointed domain	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
RNA-binding domain, RBD	Tricorn protease domain 2	1	1
SAM/Pointed domain	Toll/Interleukin receptor TIR domain	1	1
SET domain	Bromodomain	1	1
(Phosphotyrosine protein) phosphatases II	Cysteine-rich domain	1	1
Chaperone J-domain	CSL zinc finger	1	1
Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	1	1
Regulator of G-protein signaling, RGS	DBL homology domain (DH-domain)	1	1
Thioredoxin-like	Galactose-binding domain-like	1	1
ARM repeat	Toll/Interleukin receptor TIR domain	1	1
UBC-like	UBA-like	1	1
C-type lectin-like	EGF/Laminin	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
BRK domain-like	Elongation factor TFIIS domain 2	1	1
PH domain-like	RING/U-box	1	1
DEATH domain	Toll/Interleukin receptor TIR domain	1	1
ARM repeat	RING/U-box	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	1	1
WD40 repeat-like	Bromodomain	1	1
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	1	1
Dystroglycan, domain 2	Cadherin-like	1	1
TPR-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Nucleic acid-binding proteins	1	1
Second domain of FERM	RING/U-box	1	1
TPR-like	Protein prenylyltransferase	1	1
Zinc hairpin stack	Retrovirus zinc finger-like domains	1	1
PX domain	Outer arm dynein light chain 1	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	S15/NS1 RNA-binding domain	1	1
FYVE/PHD zinc finger	BRK domain-like	1	1
RNI-like	Toll/Interleukin receptor TIR domain	1	1
WD40 repeat-like	Cyclophilin-like	1	1
Ankyrin repeat	RNI-like	1	1
Multidrug efflux transporter AcrB transmembrane domain	Quinoprotein alcohol dehydrogenase-like	1	1
Nitric oxide (NO) synthase oxygenase domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
PRTase-like	Ribulose-phoshate binding barrel	1	1
C-type lectin-like	Growth factor receptor domain	1	1
L domain-like	PDZ domain-like	1	1
Growth factor receptor domain	TSP type-3 repeat	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
Rhodanese/Cell cycle control phosphatase	Cysteine proteinases	1	1
Nucleic acid-binding proteins	BRCA2 tower domain	1	1
ARM repeat	UBA-like	1	1
RING/U-box	Tropomyosin	1	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	1	1
Ubiquitin-like	Cap-Gly domain	1	1
Seven-hairpin glycosidases	PA domain	1	1
B-box zinc-binding domain	Cyclophilin-like	1	1
RING/U-box	UBA-like	1	1
F-box domain	UBC-like	1	1
UBC-like	Protein kinase-like (PK-like)	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
Ras GEF	PLC-like phosphodiesterases	1	1
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
Phoshotransferase/anion transport protein	Phoshotransferase/anion transport protein	1	1
L domain-like	Ubiquitin-like	1	1
Tudor/PWWP/MBT	DNA-binding domain	1	1
FGAM synthase PurL, linker domain	PurM C-terminal domain-like	1	1
Thioredoxin-like	TPR-like	1	1
FYVE/PHD zinc finger	SAP domain	1	1
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	1	1
"Winged helix" DNA-binding domain	Acyl-CoA N-acyltransferases (Nat)	1	1
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	1	1
CRAL/TRIO N-terminal domain	(Phosphotyrosine protein) phosphatases II	1	1
PH domain-like	"Winged helix" DNA-binding domain	1	1
Frizzled cysteine-rich domain	Trypsin-like serine proteases	1	1
DBL homology domain (DH-domain)	GTPase activation domain, GAP	1	1
P-loop containing nucleoside triphosphate hydrolases	RGC domain-like	1	1
CAD & PB1 domains	PDZ domain-like	1	1
Folate-binding domain	TrmE connector domain	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	UBA-like	1	1
Molybdenum cofactor biosynthesis proteins	MoeA N-terminal region -like	1	1
DNA-binding domain	Homeodomain-like	1	1
Homeodomain-like	FYVE/PHD zinc finger	1	1
MoaD/ThiS	ThiG-like	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	S15/NS1 RNA-binding domain	1	1
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	1	1
HesB-like domain	HesB-like domain	1	1
FYVE/PHD zinc finger	PDZ domain-like	1	1
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
Outer arm dynein light chain 1	P-loop containing nucleoside triphosphate hydrolases	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
vWA-like	Growth factor receptor domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
14-3-3 protein	14-3-3 protein	1	1
FLJ32549 domain-like	FLJ32549 C-terminal domain-like	1	1
F-box domain	Galactose-binding domain-like	1	1
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	1	1
HMG-box	HMG-box	1	1
N-acetylmuramoyl-L-alanine amidase-like	PGBD-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Tudor/PWWP/MBT	1	1
beta-lactamase/transpeptidase-like	Ankyrin repeat	1	1
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
TrkA C-terminal domain-like	TrkA C-terminal domain-like	1	1
Actin-crosslinking proteins	Actin-crosslinking proteins	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
FAH	FAH	1	1
beta-beta-alpha zinc fingers	Nucleotide-diphospho-sugar transferases	1	1
Tropomyosin	Mitotic arrest deficient-like 1, Mad1	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	YWTD domain	1	1
Complement control module/SCR domain	Immunoglobulin	1	1
Multidrug efflux transporter AcrB transmembrane domain	WD40 repeat-like	1	1
PurS-like	PurM N-terminal domain-like	1	1
Activator of Hsp90 ATPase, Aha1	Bet v1-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	Tudor/PWWP/MBT	1	1
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	1	1
RCC1/BLIP-II	POZ domain	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	1	1
BRCT domain	Lesion bypass DNA polymerase (Y-family), little finger domain	1	1
TPR-like	ARM repeat	1	1
Serine protease inhibitors	Galactose-binding domain-like	1	1
beta-Roll	beta-Roll	1	1
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	1	1
Outer arm dynein light chain 1	Toll/Interleukin receptor TIR domain	1	1
CAPPD, an extracellular domain of amyloid beta A4 protein	CAPPD, an extracellular domain of amyloid beta A4 protein	1	1
Aminoacid dehydrogenase-like, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Serine protease inhibitors	Serine protease inhibitors	1	1
EF-hand	Ubiquitin-like	1	1
Saposin	Saposin	1	1
WD40 repeat-like	Tricorn protease domain 2	1	1
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	1	1
YccV-like	ApaG-like	1	1
Frizzled cysteine-rich domain	SRCR-like	1	1
Homeodomain-like	Ribonuclease H-like	1	1
Ubiquitin-like	HAD-like	1	1
DPP6 N-terminal domain-like	ARM repeat	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
L domain-like	Pectin lyase-like	1	1
BRCT domain	DNA/RNA polymerases	1	1
FAD-linked reductases, C-terminal domain	ThiG-like	1	1
RNI-like	Immunoglobulin	1	1
WW domain	RING/U-box	1	1
Pectin lyase-like	Pectin lyase-like	1	1
MIT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
NHL repeat	WD40 repeat-like	1	1
Ubiquitin-like	Acid proteases	1	1
PDZ domain-like	RING/U-box	1	1
SH2 domain	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Invertebrate chitin-binding proteins	Trypsin-like serine proteases	1	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	1	1
Ypt/Rab-GAP domain of gyp1p	Rhodanese/Cell cycle control phosphatase	1	1
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	Homeodomain-like	1	1
Quinoprotein alcohol dehydrogenase-like	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	1	1
PLP-dependent transferases	Adenine nucleotide alpha hydrolases-like	1	1
"Winged helix" DNA-binding domain	PLP-dependent transferases	1	1
WW domain	EF-hand	1	1
HRDC-like	HRDC-like	1	1
PTS system fructose IIA component-like	PTS IIb component	1	1
TSP-1 type 1 repeat	Spermadhesin, CUB domain	1	1
FnI-like domain	Invertebrate chitin-binding proteins	1	1
L domain-like	Hormone receptor domain	1	1
Serine protease inhibitors	Invertebrate chitin-binding proteins	1	1
Protein kinase-like (PK-like)	NTF2-like	1	1
TPR-like	Fic-like	1	1
Doublecortin (DC)	Quinoprotein alcohol dehydrogenase-like	1	1
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	1	1