Domain combination pairs in Octopus bimaculoides 280

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

2020 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	1872	187
Cadherin-like	Cadherin-like	219	44
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	191	51
Ankyrin repeat	Ankyrin repeat	164	23
Ankyrin repeat	DEATH domain	150	11
EGF/Laminin	EGF/Laminin	143	95
Immunoglobulin	Immunoglobulin	124	48
RNA-binding domain, RBD	RNA-binding domain, RBD	78	19
ARM repeat	ARM repeat	68	27
FnI-like domain	FnI-like domain	62	43
Nicotinic receptor ligand binding domain-like	Neurotransmitter-gated ion-channel transmembrane pore	61	3
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	61	9
Fibronectin type III	Fibronectin type III	61	32
DBL homology domain (DH-domain)	PH domain-like	59	16
EGF/Laminin	Growth factor receptor domain	58	54
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	53	32
LDL receptor-like module	LDL receptor-like module	47	33
Actin-like ATPase domain	Actin-like ATPase domain	47	11
TPR-like	TPR-like	47	18
Concanavalin A-like lectins/glucanases	EGF/Laminin	44	29
Immunoglobulin	Fibronectin type III	42	21
Invertebrate chitin-binding proteins	Invertebrate chitin-binding proteins	42	20
TSP-1 type 1 repeat	TSP-1 type 1 repeat	41	32
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	37	13
Complement control module/SCR domain	Complement control module/SCR domain	37	28
Growth factor receptor domain	Growth factor receptor domain	35	32
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	34	3
Homeodomain-like	Homeodomain-like	33	12
Thioredoxin-like	GST C-terminal domain-like	33	5
WD40 repeat-like	WD40 repeat-like	32	14
vWA-like	vWA-like	32	13
Spectrin repeat	Spectrin repeat	31	27
P-loop containing nucleoside triphosphate hydrolases	SMAD/FHA domain	30	8
Cysteine-rich domain	PH domain-like	30	7
L domain-like	L domain-like	30	16
E set domains	E set domains	29	18
P-loop containing nucleoside triphosphate hydrolases	ABC transporter transmembrane region	28	9
(Trans)glycosidases	Chitinase insertion domain	27	5
Second domain of FERM	PH domain-like	27	17
RING/U-box	B-box zinc-binding domain	27	15
Kelch motif	POZ domain	26	5
EF-hand	EF-hand	26	12
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	26	18
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	24	12
P-loop containing nucleoside triphosphate hydrolases	PH domain-like	24	6
SH3-domain	PH domain-like	24	14
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	23	7
RING/U-box	RING/U-box	23	12
HAD-like	Calcium ATPase, transmembrane domain M	23	7
PDZ domain-like	PDZ domain-like	23	15
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	22	6
Concanavalin A-like lectins/glucanases	LDL receptor-like module	22	15
SAM/Pointed domain	SAM/Pointed domain	22	6
SH3-domain	SH3-domain	22	14
ARM repeat	Protein kinase-like (PK-like)	22	16
Cysteine-rich domain	DBL homology domain (DH-domain)	22	2
Ankyrin repeat	SOCS box-like	22	5
Ubiquitin-like	Second domain of FERM	22	16
Glucocorticoid receptor-like (DNA-binding domain)	Nuclear receptor ligand-binding domain	22	5
Cyclin-like	Cyclin-like	21	8
FYVE/PHD zinc finger	FYVE/PHD zinc finger	21	14
Hairpin loop containing domain-like	Hairpin loop containing domain-like	21	13
Tropomyosin	Tropomyosin	20	1
LDL receptor-like module	EGF/Laminin	20	13
Calponin-homology domain, CH-domain	Glucocorticoid receptor-like (DNA-binding domain)	20	2
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	20	8
Voltage-gated potassium channels	Voltage-gated potassium channels	19	9
Ubiquitin-like	PH domain-like	19	14
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	19	10
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	19	7
FAD/NAD(P)-binding domain	Glucocorticoid receptor-like (DNA-binding domain)	18	1
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	18	12
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	18	6
FAD/NAD(P)-binding domain	Calponin-homology domain, CH-domain	18	1
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	18	4
PH domain-like	PH domain-like	18	10
Sec7 domain	ARM repeat	17	2
GroES-like	NAD(P)-binding Rossmann-fold domains	17	5
MFS general substrate transporter	Kazal-type serine protease inhibitors	17	3
vWA-like	EGF/Laminin	16	14
Immunoglobulin	EGF/Laminin	16	10
Tudor/PWWP/MBT	Tudor/PWWP/MBT	16	12
SMAD/FHA domain	PH domain-like	16	2
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	15	3
Calcium ATPase, transduction domain A	HAD-like	15	5
FYVE/PHD zinc finger	Bromodomain	15	6
WW domain	WW domain	15	10
SRCR-like	SRCR-like	15	11
F-box domain	RNI-like	15	6
Kelch motif	Kelch motif	14	6
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	14	6
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	14	4
Serine protease inhibitors	Serine protease inhibitors	14	8
SH3-domain	P-loop containing nucleoside triphosphate hydrolases	14	8
Spectrin repeat	EF-hand	14	13
WD40 repeat-like	Quinoprotein alcohol dehydrogenase-like	14	10
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	14	8
L domain-like	Toll/Interleukin receptor TIR domain	13	8
(Trans)glycosidases	Glycosyl hydrolase domain	13	5
FnI-like domain	PMP inhibitors	13	12
BAR/IMD domain-like	SH3-domain	13	9
(Phosphotyrosine protein) phosphatases II	PH domain-like	13	7
TSP-1 type 1 repeat	Serine protease inhibitors	13	8
RING/U-box	NHL repeat	13	4
ARM repeat	Formin homology 2 domain (FH2 domain)	13	5
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	13	8
Chromo domain-like	Chromo domain-like	13	5
Ankyrin repeat	RING/U-box	13	7
cAMP-binding domain-like	cAMP-binding domain-like	13	8
B-box zinc-binding domain	NHL repeat	13	5
RING/U-box	TRAF domain-like	12	9
Concanavalin A-like lectins/glucanases	C-type lectin-like	12	1
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	12	5
LDL receptor-like module	Immunoglobulin	12	6
Clc chloride channel	CBS-domain pair	12	4
YWTD domain	EGF/Laminin	12	9
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	12	3
GroEL equatorial domain-like	GroEL apical domain-like	12	2
Ubiquitin-like	Ubiquitin-like	12	12
Immunoglobulin	Concanavalin A-like lectins/glucanases	12	6
Thioredoxin-like	Thioredoxin-like	12	8
SH2 domain	Protein kinase-like (PK-like)	12	6
alpha-catenin/vinculin-like	alpha-catenin/vinculin-like	12	7
ABC transporter transmembrane region	ABC transporter transmembrane region	12	5
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	12	4
Immunoglobulin	Protein kinase-like (PK-like)	12	7
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex, superhelical domain	12	6
p53-like transcription factors	E set domains	12	5
Protein kinase-like (PK-like)	Nucleotide cyclase	11	9
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	11	1
LDL receptor-like module	Trypsin-like serine proteases	11	10
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	11	7
Spermadhesin, CUB domain	Spermadhesin, CUB domain	11	10
Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	11	5
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	11	7
Cupredoxins	Cupredoxins	11	8
PH domain-like	Ypt/Rab-GAP domain of gyp1p	11	3
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	11	3
POZ domain	Voltage-gated potassium channels	11	4
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	11	3
GroEL-intermediate domain like	GroEL apical domain-like	11	1
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	11	5
MFS general substrate transporter	MFS general substrate transporter	11	4
F-box domain	WD40 repeat-like	11	5
Fibronectin type III	Ankyrin repeat	11	1
SET domain	FYVE/PHD zinc finger	11	4
Ubiquitin-like	Protein kinase-like (PK-like)	11	6
GroEL equatorial domain-like	GroEL-intermediate domain like	11	1
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	11	3
HMG-box	HMG-box	11	4
Concanavalin A-like lectins/glucanases	Growth factor receptor domain	11	8
PreATP-grasp domain	Rudiment single hybrid motif	10	5
Cysteine-rich domain	Cysteine-rich domain	10	7
Metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	10	4
Bromodomain	Bromodomain	10	4
PDZ domain-like	PH domain-like	10	6
SH2 domain	SH3-domain	10	9
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	10	5
ENTH/VHS domain	GAT-like domain	10	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	10	7
Nucleic acid-binding proteins	Nucleic acid-binding proteins	10	8
BRCT domain	BRCT domain	10	8
PH domain-like	GTPase activation domain, GAP	10	5
RCC1/BLIP-II	Hect, E3 ligase catalytic domain	10	4
Thiolase-like	Thiolase-like	10	3
RING/U-box	E set domains	10	3
DBL homology domain (DH-domain)	SH3-domain	10	6
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	10	4
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	10	1
ARM repeat	WD40 repeat-like	10	6
FYVE/PHD zinc finger	RING/U-box	10	4
PDZ domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	10	2
BEACH domain	WD40 repeat-like	10	6
Tudor/PWWP/MBT	ARID-like	9	2
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	9	5
ARM repeat	Clathrin adaptor appendage domain	9	3
Spectrin repeat	GAS2 domain-like	9	8
(Trans)glycosidases	Invertebrate chitin-binding proteins	9	4
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	9	6
Serine protease inhibitors	FnI-like domain	9	6
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	9	2
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	9	5
HIT/MYND zinc finger-like	HIT/MYND zinc finger-like	9	9
Actin depolymerizing proteins	Actin depolymerizing proteins	9	6
vWA-like	Growth factor receptor domain	9	8
Ankyrin repeat	P-loop containing nucleoside triphosphate hydrolases	9	7
EF-hand	GAS2 domain-like	9	8
Ubiquitin-like	UBA-like	9	4
PH domain-like	ArfGap/RecO-like zinc finger	9	3
Chitinase insertion domain	Invertebrate chitin-binding proteins	8	3
Tudor/PWWP/MBT	FYVE/PHD zinc finger	8	5
CalX-like	CalX-like	8	5
Regulator of G-protein signaling, RGS	DBL homology domain (DH-domain)	8	1
lambda repressor-like DNA-binding domains	Homeodomain-like	8	2
dsRNA-binding domain-like	dsRNA-binding domain-like	8	6
RCC1/BLIP-II	Galactose-binding domain-like	8	2
Calponin-homology domain, CH-domain	E set domains	8	4
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	8	4
Cysteine-rich domain	Protein kinase-like (PK-like)	8	4
YWTD domain	LDL receptor-like module	8	7
C2 domain (Calcium/lipid-binding domain, CaLB)	PH domain-like	8	6
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	8	4
RCC1/BLIP-II	RCC1/BLIP-II	8	4
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	8	3
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	8	4
GAF domain-like	GAF domain-like	8	3
Spermadhesin, CUB domain	EGF/Laminin	8	7
PreATP-grasp domain	Single hybrid motif	8	4
EF-hand	RING/U-box	8	6
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	8	3
FAS1 domain	FAS1 domain	8	4
Regulator of G-protein signaling, RGS	PH domain-like	8	1
Metalloproteases ("zincins"), catalytic domain	TSP-1 type 1 repeat	8	8
Voltage-gated potassium channels	cAMP-binding domain-like	8	5
EGF/Laminin	Fibronectin type III	8	1
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	8	5
Regulator of G-protein signaling, RGS	Cysteine-rich domain	8	1
Rudiment single hybrid motif	Single hybrid motif	8	4
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	8	4
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	8	3
RING/U-box	Galactose-binding domain-like	8	2
ArfGap/RecO-like zinc finger	Ankyrin repeat	8	5
GAF domain-like	HD-domain/PDEase-like	8	4
EGF/Laminin	Complement control module/SCR domain	8	7
RCC1/BLIP-II	RING/U-box	8	2
PDZ domain-like	SH3-domain	7	5
HMG-box	FYVE/PHD zinc finger	7	2
C2 domain (Calcium/lipid-binding domain, CaLB)	GTPase activation domain, GAP	7	4
Fibronectin type III	Protein kinase-like (PK-like)	7	7
PMP inhibitors	PMP inhibitors	7	6
Concanavalin A-like lectins/glucanases	WD40 repeat-like	7	2
HIT/MYND zinc finger-like	TPR-like	7	4
Cullin homology domain	"Winged helix" DNA-binding domain	7	4
FYVE/PHD zinc finger	Chromo domain-like	7	2
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	7	2
P-loop containing nucleoside triphosphate hydrolases	Protein kinase-like (PK-like)	7	3
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	7	6
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	7	4
Intermediate filament protein, coiled coil region	Myosin rod fragments	7	6
p53-like transcription factors	DNA-binding protein LAG-1 (CSL)	7	2
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	7	5
Voltage-gated potassium channels	Periplasmic binding protein-like II	7	6
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	7	5
Cysteine proteinases	RING/U-box	7	7
Metalloproteases ("zincins"), catalytic domain	Concanavalin A-like lectins/glucanases	7	2
Purple acid phosphatase, N-terminal domain	Metallo-dependent phosphatases	7	3
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	7	4
Ankyrin repeat	SAM/Pointed domain	7	7
CoA-dependent acyltransferases	CoA-dependent acyltransferases	7	2
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	7	5
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	7	5
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	7	4
Spermadhesin, CUB domain	Complement control module/SCR domain	7	5
ClpP/crotonase	ClpP/crotonase	7	3
ARM repeat	Subdomain of clathrin and coatomer appendage domain	7	2
HMG-box	P-loop containing nucleoside triphosphate hydrolases	7	2
Glucocorticoid receptor-like (DNA-binding domain)	Homeodomain-like	7	6
Voltage-gated potassium channels	E set domains	7	2
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	7	3
YWTD domain	YWTD domain	7	7
Plakin repeat	Plakin repeat	7	6
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	7	1
DNA-binding protein LAG-1 (CSL)	E set domains	7	2
BAR/IMD domain-like	PH domain-like	7	4
HMG-box	Chromo domain-like	7	2
Calponin-homology domain, CH-domain	Spectrin repeat	7	5
PHM/PNGase F	PHM/PNGase F	7	4
Myosin rod fragments	Myosin rod fragments	7	4
Spermadhesin, CUB domain	LDL receptor-like module	7	7
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	7	5
Ankyrin repeat	SH3-domain	7	4
Hairpin loop containing domain-like	Complement control module/SCR domain	7	7
PP2C-like	Protein serine/threonine phosphatase 2C, C-terminal domain	6	1
EF-G C-terminal domain-like	EF-G C-terminal domain-like	6	4
Class I glutamine amidotransferase-like	Glutathione synthetase ATP-binding domain-like	6	3
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	6	4
Second domain of FERM	alpha-catenin/vinculin-like	6	1
Class I glutamine amidotransferase-like	Carbamoyl phosphate synthetase, large subunit connection domain	6	3
L domain-like	Growth factor receptor domain	6	5
TSP-1 type 1 repeat	Immunoglobulin	6	6
Spectrin repeat	Plakin repeat	6	5
WD40 repeat-like	TPR-like	6	4
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	6	3
A middle domain of Talin 1	alpha-catenin/vinculin-like	6	1
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	6	3
L domain-like	Immunoglobulin	6	4
PH domain-like	Protein kinase-like (PK-like)	6	5
SH2 domain	PH domain-like	6	5
Tudor/PWWP/MBT	HIT/MYND zinc finger-like	6	2
SRCR-like	Trypsin-like serine proteases	6	6
PH domain-like	alpha-catenin/vinculin-like	6	1
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	6	3
PreATP-grasp domain	PreATP-grasp domain	6	3
Family A G protein-coupled receptor-like	Family A G protein-coupled receptor-like	6	6
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	6	3
PreATP-grasp domain	Methylglyoxal synthase-like	6	3
EF-hand	PLC-like phosphodiesterases	6	5
PH domain-like	I/LWEQ domain	6	1
Terpenoid cyclases/Protein prenyltransferases	Alpha-macroglobulin receptor domain	6	3
Rhodanese/Cell cycle control phosphatase	(Phosphotyrosine protein) phosphatases II	6	3
Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	6	3
Intermediate filament protein, coiled coil region	Lamin A/C globular tail domain	6	4
EF-hand	Cysteine-rich domain	6	2
ARM repeat	Ankyrin repeat	6	4
Kringle-like	Kringle-like	6	2
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	6	5
Protein kinase-like (PK-like)	PX domain	6	5
SET domain	HIT/MYND zinc finger-like	6	3
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	6	4
DEATH domain	Caspase-like	6	2
Cullin repeat-like	Cullin homology domain	6	3
Cysteine-rich domain	GTPase activation domain, GAP	6	4
A middle domain of Talin 1	I/LWEQ domain	6	1
Cysteine proteinases	EF-hand	6	4
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipoxigenase	6	1
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	6	2
Concanavalin A-like lectins/glucanases	ARM repeat	6	2
Ubiquitin-like	RING/U-box	6	4
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	6	4
Subtilisin-like	Galactose-binding domain-like	6	5
Metalloproteases ("zincins"), catalytic domain	Hemopexin-like domain	6	5
Inosine monophosphate dehydrogenase (IMPDH)	Inosine monophosphate dehydrogenase (IMPDH)	6	2
RCC1/BLIP-II	E set domains	6	1
PH domain-like	WD40 repeat-like	6	3
PDZ domain-like	P-loop containing nucleoside triphosphate hydrolases	6	4
Second domain of FERM	A middle domain of Talin 1	6	1
Galactose-binding domain-like	Hect, E3 ligase catalytic domain	6	4
Spectrin repeat	PH domain-like	6	3
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	6	4
TSP-1 type 1 repeat	FnI-like domain	6	3
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	6	3
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	6	2
PH domain-like	A middle domain of Talin 1	6	1
Kringle-like	Protein kinase-like (PK-like)	6	2
Ankyrin repeat	Protein kinase-like (PK-like)	6	5
Ankyrin repeat	PH domain-like	6	3
SAM/Pointed domain	PH domain-like	6	3
Tudor/PWWP/MBT	HMG-box	6	1
Class I glutamine amidotransferase-like	PreATP-grasp domain	6	3
Periplasmic binding protein-like I	Periplasmic binding protein-like II	6	5
FF domain	FF domain	6	2
Translation proteins	EF-G C-terminal domain-like	6	4
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	6	2
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	6	3
I/LWEQ domain	alpha-catenin/vinculin-like	6	1
E set domains	Galactose-binding domain-like	6	1
RNI-like	EF-hand	6	2
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	6	2
L domain-like	Family A G protein-coupled receptor-like	6	4
C2 domain (Calcium/lipid-binding domain, CaLB)	Ubiquitin-like	6	4
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	6	3
Ran binding protein zinc finger-like	RNA-binding domain, RBD	6	2
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	6	2
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	6	6
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	6	3
WW domain	FF domain	6	2
Second domain of FERM	I/LWEQ domain	6	1
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	6	4
LDL receptor-like module	SRCR-like	6	6
PH domain-like	BEACH domain	6	3
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	6	2
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	5	5
Sema domain	Plexin repeat	5	5
ARM repeat	Cysteine proteinases	5	3
PurM N-terminal domain-like	PurM C-terminal domain-like	5	3
Plakin repeat	EF-hand	5	4
POZ domain	POZ domain	5	5
SAM/Pointed domain	GTPase activation domain, GAP	5	2
C2 domain (Calcium/lipid-binding domain, CaLB)	ARM repeat	5	4
Mib/herc2 domain-like	Galactose-binding domain-like	5	3
Zn-finger domain of Sec23/24	vWA-like	5	2
PGBD-like	Metalloproteases ("zincins"), catalytic domain	5	4
EGF/Laminin	Invertebrate chitin-binding proteins	5	5
ARM repeat	PH domain-like	5	2
PKD domain	PKD domain	5	5
SNARE-like	SNARE fusion complex	5	2
Metalloproteases ("zincins"), catalytic domain	Blood coagulation inhibitor (disintegrin)	5	2
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	5	2
vWA-like	Helical domain of Sec23/24	5	2
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	5	3
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	5	2
RING/U-box	Homeodomain-like	5	4
Tudor/PWWP/MBT	SAM/Pointed domain	5	3
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	5	2
Periplasmic binding protein-like I	Periplasmic binding protein-like I	5	4
Calpain large subunit, middle domain (domain III)	EF-hand	5	3
Nucleotidylyl transferase	S15/NS1 RNA-binding domain	5	3
Doublecortin (DC)	Doublecortin (DC)	5	4
GST C-terminal domain-like	S15/NS1 RNA-binding domain	5	3
BAR/IMD domain-like	Ankyrin repeat	5	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Carbamoyl phosphate synthetase, large subunit connection domain	5	2
Translation proteins	Ribosomal protein S5 domain 2-like	5	3
TPR-like	SET domain	5	2
Succinyl-CoA synthetase domains	NAD(P)-binding Rossmann-fold domains	5	2
BPTI-like	BPTI-like	5	4
Fibronectin type III	(Phosphotyrosine protein) phosphatases II	5	5
PH domain-like	Oxysterol-binding protein-like	5	3
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	5	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Glutathione synthetase ATP-binding domain-like	5	2
Glucocorticoid receptor-like (DNA-binding domain)	POZ domain	5	3
GST C-terminal domain-like	Nucleotidylyl transferase	5	3
NHL repeat	Soluble quinoprotein glucose dehydrogenase	5	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	5	2
SH2 domain	SOCS box-like	5	2
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	5	3
DEATH domain	DEATH domain	5	1
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	5	3
Flavoproteins	Riboflavin synthase domain-like	5	3
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	5	3
L domain-like	P-loop containing nucleoside triphosphate hydrolases	5	4
Kazal-type serine protease inhibitors	Kazal-type serine protease inhibitors	5	4
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	5	2
Concanavalin A-like lectins/glucanases	P-loop containing nucleoside triphosphate hydrolases	5	4
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	5	1
Integrin domains	Integrin domains	5	4
L27 domain	PDZ domain-like	5	3
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	5	2
GTPase activation domain, GAP	ARM repeat	5	1
Integrin alpha N-terminal domain	Integrin domains	5	4
Bromodomain	Tudor/PWWP/MBT	5	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Methylglyoxal synthase-like	5	2
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	5	2
Periplasmic binding protein-like I	Protein kinase-like (PK-like)	5	5
SAM/Pointed domain	"Winged helix" DNA-binding domain	5	4
Periplasmic binding protein-like I	Voltage-gated potassium channels	5	4
ArfGap/RecO-like zinc finger	SH3-domain	5	2
TPR-like	ARM repeat	5	5
Carbamoyl phosphate synthetase, small subunit N-terminal domain	PreATP-grasp domain	5	2
WW domain	Hect, E3 ligase catalytic domain	5	5
Cullin repeat-like	"Winged helix" DNA-binding domain	5	2
EF-hand	Eferin C-derminal domain-like	5	1
FKBP-like	TPR-like	5	3
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	5	1
Ran binding protein zinc finger-like	RING/U-box	5	3
Mib/herc2 domain-like	Hect, E3 ligase catalytic domain	5	3
Intermediate filament protein, coiled coil region	Intermediate filament protein, coiled coil region	5	4
L domain-like	Protein kinase-like (PK-like)	5	4
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	5	2
vWA-like	beta-sandwich domain of Sec23/24	5	2
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex; beta-sheet shell regions	5	3
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	5	2
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	5	3
C2 domain (Calcium/lipid-binding domain, CaLB)	vWA-like	5	3
Protein kinase-like (PK-like)	SH3-domain	5	5
Plakin repeat	GAS2 domain-like	5	4
Single hybrid motif	CoA-dependent acyltransferases	5	5
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	5	3
Di-copper centre-containing domain	C-terminal domain of mollusc hemocyanin	5	5
Zn-finger domain of Sec23/24	beta-sandwich domain of Sec23/24	5	2
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	5	4
BRK domain-like	P-loop containing nucleoside triphosphate hydrolases	5	2
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	5	3
RUN domain-like	SH3-domain	5	2
Second domain of FERM	Second domain of FERM	5	5
ARM repeat	"Winged helix" DNA-binding domain	5	2
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	5	5
PDZ domain-like	DBL homology domain (DH-domain)	5	3
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	5	3
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	5	2
Ribonuclease H-like	DNA/RNA polymerases	5	5
MAST3 pre-PK domain-like	Protein kinase-like (PK-like)	4	1
PABC (PABP) domain	Hect, E3 ligase catalytic domain	4	1
Carbamoyl phosphate synthetase, large subunit connection domain	Aspartate/ornithine carbamoyltransferase	4	1
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	4	3
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	4	3
E set domains	P-loop containing nucleoside triphosphate hydrolases	4	2
WD40 repeat-like	SNARE fusion complex	4	2
SAM/Pointed domain	ArfGap/RecO-like zinc finger	4	1
Cysteine proteinases	Transglutaminase, two C-terminal domains	4	3
Rudiment single hybrid motif	ClpP/crotonase	4	1
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	4	1
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	4	1
Plexin repeat	E set domains	4	4
EGF/Laminin	Integrin beta tail domain	4	3
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	4	4
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	4	4
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	4	1
PH domain-like	PLC-like phosphodiesterases	4	3
MAST3 pre-PK domain-like	PDZ domain-like	4	1
C-type lectin-like	C-type lectin-like	4	3
Glutathione synthetase ATP-binding domain-like	Composite domain of metallo-dependent hydrolases	4	1
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	4	4
Methylglyoxal synthase-like	Metallo-dependent hydrolases	4	1
Glutathione synthetase ATP-binding domain-like	Aspartate/ornithine carbamoyltransferase	4	1
NAD(P)-binding Rossmann-fold domains	Citrate synthase	4	1
Methylglyoxal synthase-like	Composite domain of metallo-dependent hydrolases	4	1
Class I glutamine amidotransferase-like	Aspartate/ornithine carbamoyltransferase	4	1
SH2 domain	SH2 domain	4	4
HSP20-like chaperones	HSP20-like chaperones	4	2
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	4	1
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	4	1
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	4	2
Ubiquitin-like	Ras GEF	4	3
BRK domain-like	Bromodomain	4	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	4	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Composite domain of metallo-dependent hydrolases	4	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	S15/NS1 RNA-binding domain	4	2
PreATP-grasp domain	ClpP/crotonase	4	1
Trypsin-like serine proteases	Concanavalin A-like lectins/glucanases	4	4
Carbamoyl phosphate synthetase, large subunit connection domain	Composite domain of metallo-dependent hydrolases	4	1
PH domain-like	Ras GEF	4	3
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	4	2
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	4	1
Protein kinase-like (PK-like)	WD40 repeat-like	4	3
Spectrin repeat	SH3-domain	4	4
Mib/herc2 domain-like	RING/U-box	4	2
Ubiquitin-like	Ran binding protein zinc finger-like	4	2
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	4	3
beta-beta-alpha zinc fingers	Homeodomain-like	4	4
P-loop containing nucleoside triphosphate hydrolases	TPR-like	4	4
Class I glutamine amidotransferase-like	Composite domain of metallo-dependent hydrolases	4	1
SMAD/FHA domain	C2 domain (Calcium/lipid-binding domain, CaLB)	4	1
FLJ32549 domain-like	FLJ32549 C-terminal domain-like	4	1
Sec7 domain	PH domain-like	4	3
Concanavalin A-like lectins/glucanases	PH domain-like	4	1
ARM repeat	P-loop containing nucleoside triphosphate hydrolases	4	2
Clavaminate synthase-like	S-adenosyl-L-methionine-dependent methyltransferases	4	1
PreATP-grasp domain	Metallo-dependent hydrolases	4	1
P-loop containing nucleoside triphosphate hydrolases	dsRNA-binding domain-like	4	2
GST C-terminal domain-like	Methionyl-tRNA synthetase (MetRS), Zn-domain	4	2
WW domain	RING/U-box	4	3
ARM repeat	BEACH domain	4	1
Hormone receptor domain	Family A G protein-coupled receptor-like	4	3
Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	4	4
Phospholipase D/nuclease	Phospholipase D/nuclease	4	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Metallo-dependent hydrolases	4	1
SAM/Pointed domain	SH2 domain	4	3
Class I glutamine amidotransferase-like	Metallo-dependent hydrolases	4	1
PH domain-like	FYVE/PHD zinc finger	4	4
E set domains	Ankyrin repeat	4	2
Metalloproteases ("zincins"), catalytic domain	Spermadhesin, CUB domain	4	2
Ras GEF	EF-hand	4	1
Galactose-binding domain-like	Galactose-binding domain-like	4	3
Glutathione synthetase ATP-binding domain-like	Citrate synthase	4	1
RNA-binding domain, RBD	Retrovirus zinc finger-like domains	4	2
SET domain	Bromodomain	4	1
PreATP-grasp domain	Composite domain of metallo-dependent hydrolases	4	1
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	4	4
Carbamoyl phosphate synthetase, large subunit connection domain	Metallo-dependent hydrolases	4	1
WW domain	EF-hand	4	3
USP8 N-terminal domain-like	JAB1/MPN domain	4	1
RNA-binding domain, RBD	Clavaminate synthase-like	4	1
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	4	4
B-box zinc-binding domain	E set domains	4	2
E set domains	Transglutaminase, two C-terminal domains	4	3
NAD(P)-binding Rossmann-fold domains	ACP-like	4	2
tRNA-binding arm	Class II aaRS and biotin synthetases	4	3
C2 domain (Calcium/lipid-binding domain, CaLB)	Cysteine-rich domain	4	2
Succinyl-CoA synthetase domains	Citrate synthase	4	1
ArfGap/RecO-like zinc finger	GTPase activation domain, GAP	4	1
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	4	3
Thioredoxin-like	Ubiquitin-like	4	2
E set domains	Cysteine proteinases	4	3
POZ domain	beta-beta-alpha zinc fingers	4	4
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	4	2
RCC1/BLIP-II	PABC (PABP) domain	4	1
Methylglyoxal synthase-like	Aspartate/ornithine carbamoyltransferase	4	1
ARM repeat	alpha/beta-Hydrolases	4	2
Metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	4	1
HLH, helix-loop-helix DNA-binding domain	PYP-like sensor domain (PAS domain)	4	3
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	S15/NS1 RNA-binding domain	4	2
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	4	1
Galactose mutarotase-like	(Trans)glycosidases	4	2
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	4	1
Spermadhesin, CUB domain	Growth factor receptor domain	4	4
Composite domain of metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	4	1
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	4	4
SMAD/FHA domain	PX domain	4	1
C-type lectin-like	LDL receptor-like module	4	4
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	4	3
PH domain-like	EF-hand	4	3
C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	4	4
Protein kinase-like (PK-like)	PDZ domain-like	4	1
P-loop containing nucleoside triphosphate hydrolases	PX domain	4	1
Bromodomain	HIT/MYND zinc finger-like	4	1
E set domains	NHL repeat	4	2
P-loop containing nucleoside triphosphate hydrolases	C2 domain (Calcium/lipid-binding domain, CaLB)	4	1
Di-copper centre-containing domain	Di-copper centre-containing domain	4	4
Glutathione synthetase ATP-binding domain-like	Metallo-dependent hydrolases	4	1
TPR-like	Protein kinase-like (PK-like)	4	4
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	4	2
(Phosphotyrosine protein) phosphatases II	Cysteine-rich domain	4	2
Ankyrin repeat	alpha-catenin/vinculin-like	4	1
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	4	2
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	4	2
Concanavalin A-like lectins/glucanases	BEACH domain	4	1
Glutathione synthetase ATP-binding domain-like	NAD(P)-binding Rossmann-fold domains	4	1
SET domain	beta-beta-alpha zinc fingers	4	3
C-type lectin-like	Hairpin loop containing domain-like	4	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Aspartate/ornithine carbamoyltransferase	4	1
Carboxypeptidase regulatory domain-like	Soluble quinoprotein glucose dehydrogenase	4	1
RNA-binding domain, RBD	Tudor/PWWP/MBT	4	3
Acid proteases	DNA/RNA polymerases	4	2
SEA domain	Frizzled cysteine-rich domain	4	2
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	4	2
Ribosomal L27 protein-like	Nucleic acid-binding proteins	4	2
Sec63 N-terminal domain-like	E set domains	4	3
BAR/IMD domain-like	GTPase activation domain, GAP	4	4
POZ domain	Galactose oxidase, central domain	4	3
Retrovirus zinc finger-like domains	P-loop containing nucleoside triphosphate hydrolases	4	3
PDZ domain-like	SAM/Pointed domain	4	4
PAZ domain	Ribonuclease H-like	4	3
Periplasmic binding protein-like I	Nucleotide cyclase	4	4
Ankyrin repeat	L domain-like	4	3
Ypt/Rab-GAP domain of gyp1p	RUN domain-like	4	1
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	4	3
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	4	1
Single hybrid motif	ClpP/crotonase	4	1
Myosin rod fragments	Lamin A/C globular tail domain	4	3
TGS-like	ThrRS/AlaRS common domain	4	3
PreATP-grasp domain	Aspartate/ornithine carbamoyltransferase	4	1
Cysteine proteinases	Cysteine proteinases	4	4
Ras GEF	Cysteine-rich domain	4	1
TAF(II)230 TBP-binding fragment	Bromodomain	4	1
GST C-terminal domain-like	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	4	2
Carboxypeptidase regulatory domain-like	NHL repeat	4	1
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	4	1
FYVE/PHD zinc finger	HIT/MYND zinc finger-like	4	1
Ankyrin repeat	Eukaryotic type KH-domain (KH-domain type I)	4	1
Ypt/Rab-GAP domain of gyp1p	SH3-domain	4	1
MIR domain	MIR domain	3	3
Ubiquitin-like	Acid proteases	3	1
t-snare proteins	SNARE fusion complex	3	2
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	tRNA-binding arm	3	1
B-box zinc-binding domain	Calcium-dependent phosphotriesterase	3	3
MIR domain	IP3 receptor type 1 binding core, domain 2	3	3
UBA-like	UBA-like	3	2
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	3	1
LDL receptor-like module	Growth factor receptor domain	3	3
Serine protease inhibitors	LDL receptor-like module	3	3
Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	3	3
YWTD domain	Growth factor receptor domain	3	3
FKBP-like	EF-hand	3	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	3	3
Ubiquitin-like	ARM repeat	3	2
Complement control module/SCR domain	Growth factor receptor domain	3	3
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	3	3
SH2 domain	GTPase activation domain, GAP	3	3
P-loop containing nucleoside triphosphate hydrolases	Tudor/PWWP/MBT	3	3
TB module/8-cys domain	Growth factor receptor domain	3	3
Plexin repeat	Integrin domains	3	2
CCCH zinc finger	CCCH zinc finger	3	2
SAM/Pointed domain	RING/U-box	3	2
ARM repeat	Toll/Interleukin receptor TIR domain	3	2
WD40 repeat-like	Hect, E3 ligase catalytic domain	3	1
PX domain	SH3-domain	3	3
DUSP-like	Cysteine proteinases	3	3
Integrin domains	EGF/Laminin	3	2
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	3	2
Tryptophan synthase beta subunit-like PLP-dependent enzymes	CBS-domain pair	3	1
RING/U-box	UBA-like	3	2
PA domain	Zn-dependent exopeptidases	3	2
ARM repeat	Chaperone J-domain	3	1
"Winged helix" DNA-binding domain	SMAD/FHA domain	3	1
Snake toxin-like	Protein kinase-like (PK-like)	3	3
SMAD/FHA domain	BRCT domain	3	2
Homeodomain-like	POZ domain	3	3
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	3	2
vWA-like	Integrin domains	3	2
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	3	2
PriA/YqbF domain	GINS helical bundle-like	3	2
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	3	2
alpha/beta-Hydrolases	Lipase/lipooxygenase domain (PLAT/LH2 domain)	3	1
Nucleic acid-binding proteins	BRCT domain	3	3
P-loop containing nucleoside triphosphate hydrolases	TGS-like	3	1
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	3	2
(Trans)glycosidases	E set domains	3	2
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	3	2
Growth factor receptor domain	Invertebrate chitin-binding proteins	3	3
TGS-like	Class II aaRS and biotin synthetases	3	2
Myosin rod fragments	Tropomyosin	3	2
RING/U-box	P-loop containing nucleoside triphosphate hydrolases	3	2
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	3	1
SAP domain	RNA-binding domain, RBD	3	2
TPR-like	HCP-like	3	3
RING/U-box	Calcium-dependent phosphotriesterase	3	3
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	P-loop containing nucleoside triphosphate hydrolases	3	1
HLH, helix-loop-helix DNA-binding domain	Orange domain-like	3	1
Nucleoside diphosphate kinase, NDK	Nucleoside diphosphate kinase, NDK	3	2
C-type lectin-like	Spermadhesin, CUB domain	3	3
Protein kinase-like (PK-like)	Polo-box domain	3	2
Kringle-like	Immunoglobulin	3	1
CRAL/TRIO domain	Spectrin repeat	3	3
Calponin-homology domain, CH-domain	Calponin-homology domain, CH-domain	3	2
DEATH domain	RBP11-like subunits of RNA polymerase	3	1
EF-hand	Mitochondrial carrier	3	3
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	3	1
Concanavalin A-like lectins/glucanases	Complement control module/SCR domain	3	3
UBC-like	RING/U-box	3	3
C-type lectin-like	Immunoglobulin	3	3
RCC1/BLIP-II	Concanavalin A-like lectins/glucanases	3	1
Tudor/PWWP/MBT	RING/U-box	3	2
RUN domain-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	3	1
Second domain of FERM	SH3-domain	3	3
RNI-like	L domain-like	3	3
FYVE/PHD zinc finger	Clavaminate synthase-like	3	3
PDZ domain-like	Ubiquitin-like	3	2
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	3	2
Cysteine proteinases	UBA-like	3	2
PUA domain-like	P-loop containing nucleoside triphosphate hydrolases	3	2
TRAF domain-like	TRAF domain-like	3	3
Heme-dependent peroxidases	TSP-1 type 1 repeat	3	2
L domain-like	Fibronectin type III	3	3
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	3	1
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	3	2
Amine oxidase N-terminal region	Amine oxidase N-terminal region	3	1
Guanido kinase N-terminal domain	Glutamine synthetase/guanido kinase	3	2
Hermes dimerisation domain	Ribonuclease H-like	3	2
GYF domain	Chaperone J-domain	3	1
CAD & PB1 domains	Protein kinase-like (PK-like)	3	2
Nucleic acid-binding proteins	Translation proteins SH3-like domain	3	2
Glutaminase/Asparaginase	Ankyrin repeat	3	2
FYVE/PHD zinc finger	SAP domain	3	1
NAD(P)-binding Rossmann-fold domains	alpha/beta-Hydrolases	3	2
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	3	3
PGBD-like	Hemopexin-like domain	3	3
Phosphofructokinase	Phosphofructokinase	3	1
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	3	2
YWTD domain	Quinoprotein alcohol dehydrogenase-like	3	2
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	3	2
PX domain	BAR/IMD domain-like	3	3
RNase III domain-like	dsRNA-binding domain-like	3	2
Carbohydrate-binding domain	beta-N-acetylhexosaminidase-like domain	3	2
Cap-Gly domain	Cap-Gly domain	3	3
Ankyrin repeat	ADP-ribosylation	3	3
Histone-fold	ARM repeat	3	2
Invertebrate chitin-binding proteins	Concanavalin A-like lectins/glucanases	3	3
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	3	2
EGF/Laminin	Family A G protein-coupled receptor-like	3	1
Concanavalin A-like lectins/glucanases	Family A G protein-coupled receptor-like	3	1
ValRS/IleRS/LeuRS editing domain	tRNA-binding arm	3	1
Nucleotidylyl transferase	tRNA-binding arm	3	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	3	3
Kazal-type serine protease inhibitors	Growth factor receptor domain	3	2
Outer arm dynein light chain 1	L domain-like	3	3
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	3	2
PsbU/PolX domain-like	Nucleotidyltransferase	3	2
Calponin-homology domain, CH-domain	EF-hand	3	3
Homeodomain-like	FAD/NAD(P)-binding domain	3	2
Alkaline phosphatase-like	His-Me finger endonucleases	3	2
SNARE fusion complex	SNARE fusion complex	3	2
Carbon-nitrogen hydrolase	HIT-like	3	1
Cysteine-rich domain	SAM/Pointed domain	3	3
L27 domain	P-loop containing nucleoside triphosphate hydrolases	3	1
Flavoproteins	Radical SAM enzymes	3	1
beta-beta-alpha zinc fingers	Formin homology 2 domain (FH2 domain)	3	3
ARM repeat	UBA-like	3	2
Plexin repeat	vWA-like	3	2
FnI-like domain	EGF/Laminin	3	3
Toll/Interleukin receptor TIR domain	Toll/Interleukin receptor TIR domain	3	2
RNase III domain-like	RNase III domain-like	3	2
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	3	1
Amine oxidase N-terminal region	Amine oxidase catalytic domain	3	1
"Winged helix" DNA-binding domain	PH domain-like	3	2
Transducin (heterotrimeric G protein), gamma chain	Regulator of G-protein signaling, RGS	3	2
SH3-domain	EF-hand	3	3
Ypt/Rab-GAP domain of gyp1p	Rhodanese/Cell cycle control phosphatase	3	2
RING/U-box	SH2 domain	3	2
Ran binding protein zinc finger-like	Cysteine proteinases	3	1
ATP-dependent DNA ligase DNA-binding domain	BRCT domain	3	3
RuvA domain 2-like	RuvA domain 2-like	3	3
Chaperone J-domain	Thioredoxin-like	3	2
SAP domain	RING/U-box	3	1
P-loop containing nucleoside triphosphate hydrolases	Ubiquitin-like	3	3
Cadherin-like	Concanavalin A-like lectins/glucanases	3	3
Protein kinase-like (PK-like)	RCC1/BLIP-II	3	1
PABC (PABP) domain	PABC (PABP) domain	3	2
Ankyrin repeat	Mib/herc2 domain-like	3	2
Carbohydrate-binding domain	(Trans)glycosidases	3	2
P-loop containing nucleoside triphosphate hydrolases	EF-hand	3	2
Carbohydrate-binding domain	E set domains	3	2
CAD & PB1 domains	RING/U-box	3	2
Transglutaminase, two C-terminal domains	Transglutaminase, two C-terminal domains	3	2
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	3	2
Ubiquitin-like	Cysteine-rich domain	3	2
Concanavalin A-like lectins/glucanases	Hect, E3 ligase catalytic domain	3	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	3	2
P-loop containing nucleoside triphosphate hydrolases	Nucleotidylyl transferase	3	2
RCC1/BLIP-II	WD40 repeat-like	3	1
Regulator of G-protein signaling, RGS	PX domain	3	1
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	3	2
EGF/Laminin	TB module/8-cys domain	3	3
L27 domain	SH3-domain	3	1
Calponin-homology domain, CH-domain	PH domain-like	3	1
Ubiquitin-like	SH3-domain	3	3
AN1-like Zinc finger	AN1-like Zinc finger	3	2
ACT-like	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	3	2
beta-N-acetylhexosaminidase-like domain	E set domains	3	2
(Phosphotyrosine protein) phosphatases II	FYVE/PHD zinc finger	3	2
WGR domain-like	Domain of poly(ADP-ribose) polymerase	3	3
Acid proteases	UBA-like	3	1
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	3	1
RING/U-box	WD40 repeat-like	3	3
Growth factor receptor domain	Protein kinase-like (PK-like)	3	3
Cap-Gly domain	Ubiquitin-like	3	3
DEATH domain	Protein kinase-like (PK-like)	3	1
Galactose-binding domain-like	(Trans)glycosidases	3	3
beta-sandwich domain of Sec23/24	beta-beta-alpha zinc fingers	3	2
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	3	2
RUN domain-like	RUN domain-like	3	1
Invertebrate chitin-binding proteins	Trypsin-like serine proteases	3	3
SH3-domain	GTPase activation domain, GAP	3	3
Homeodomain-like	FAD-linked reductases, C-terminal domain	3	2
WGR domain-like	ADP-ribosylation	3	3
TSP-1 type 1 repeat	EGF/Laminin	3	3
TATA-box binding protein-like	DNA-glycosylase	3	1
Acetyl-CoA synthetase-like	ACP-like	3	2
ARM repeat	GYF domain	3	1
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	2	1
Glucocorticoid receptor-like (DNA-binding domain)	FYVE/PHD zinc finger	2	1
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	2	2
Zn-dependent exopeptidases	Transferrin receptor-like dimerisation domain	2	2
Macro domain-like	Zn-dependent exopeptidases	2	1
RING/U-box	Hect, E3 ligase catalytic domain	2	1
EGF/Laminin	Methyl-accepting chemotaxis protein (MCP) signaling domain	2	2
CAD & PB1 domains	UBA-like	2	1
Cadherin-like	Dystroglycan, domain 2	2	2
Multidrug efflux transporter AcrB transmembrane domain	WD40 repeat-like	2	1
Cadherin-like	EGF/Laminin	2	2
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	2	2
FabD/lysophospholipase-like	ACP-like	2	1
Annexin	Annexin	2	1
Formyltransferase	FMT C-terminal domain-like	2	2
Taf5 N-terminal domain-like	WD40 repeat-like	2	1
PK beta-barrel domain-like	PK C-terminal domain-like	2	1
Metalloproteases ("zincins"), catalytic domain	Hairpin loop containing domain-like	2	2
His-Me finger endonucleases	HIT/MYND zinc finger-like	2	1
Cap-Gly domain	L domain-like	2	2
C2 domain (Calcium/lipid-binding domain, CaLB)	WW domain	2	2
Pectin lyase-like	Pectin lyase-like	2	2
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Translation proteins	ThrRS/AlaRS common domain	2	1
PDZ domain-like	(Phosphotyrosine protein) phosphatases II	2	2
RING/U-box	Nuclear receptor coactivator interlocking domain	2	2
cAMP-binding domain-like	Protein kinase-like (PK-like)	2	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	2	1
Cytochrome b5-like heme/steroid binding domain	Galactose-binding domain-like	2	1
ARM repeat	Zn-dependent exopeptidases	2	1
Plexin repeat	EGF/Laminin	2	1
L domain-like	Ubiquitin-like	2	2
Acetyl-CoA synthetase-like	NAD(P)-binding Rossmann-fold domains	2	1
SAM/Pointed domain	ADP-ribosylation	2	2
Alkaline phosphatase-like	Alkaline phosphatase-like	2	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	2	1
EGF/Laminin	Heme-dependent peroxidases	2	1
L domain-like	ADP-ribosylglycohydrolase	2	1
S-adenosyl-L-methionine-dependent methyltransferases	GroES-like	2	1
PurM C-terminal domain-like	Class I glutamine amidotransferase-like	2	1
Spermadhesin, CUB domain	Concanavalin A-like lectins/glucanases	2	1
LDL receptor-like module	Complement control module/SCR domain	2	2
Immunoglobulin	Family A G protein-coupled receptor-like	2	1
PAH2 domain	PAH2 domain	2	2
Surp module (SWAP domain)	Surp module (SWAP domain)	2	2
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	2	1
Spermadhesin, CUB domain	Kelch motif	2	2
Protein kinase-like (PK-like)	FAT domain of focal adhesion kinase	2	2
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	2	2
Tudor/PWWP/MBT	6-phosphogluconate dehydrogenase C-terminal domain-like	2	1
Tudor/PWWP/MBT	Hect, E3 ligase catalytic domain	2	1
EF-hand	NAD kinase/diacylglycerol kinase-like	2	1
"Winged helix" DNA-binding domain	E set domains	2	1
HSP20-like chaperones	TPR-like	2	2
Ubiquitin-like	FAT domain of focal adhesion kinase	2	2
Probable ACP-binding domain of malonyl-CoA ACP transacylase	NAD(P)-binding Rossmann-fold domains	2	1
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	2	2
YVTN repeat-like/Quinoprotein amine dehydrogenase	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	2
Eukaryotic type KH-domain (KH-domain type I)	Retrovirus zinc finger-like domains	2	1
C2 domain (Calcium/lipid-binding domain, CaLB)	DBL homology domain (DH-domain)	2	1
PreATP-grasp domain	Formyltransferase	2	1
EF-hand	WD40 repeat-like	2	2
ARM repeat	Hect, E3 ligase catalytic domain	2	2
Mib/herc2 domain-like	Tudor/PWWP/MBT	2	1
Tudor/PWWP/MBT	Galactose-binding domain-like	2	1
E set domains	Terpenoid cyclases/Protein prenyltransferases	2	1
PDZ domain-like	DEATH domain	2	1
Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	2	2
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	2	2
A DNA-binding domain in eukaryotic transcription factors	Leucine zipper domain	2	2
Periplasmic binding protein-like II	Periplasmic binding protein-like II	2	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	2	1
Tex N-terminal region-like	RuvA domain 2-like	2	2
cAMP-binding domain-like	Ras GEF	2	2
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	1
Rudiment single hybrid motif	Aldolase	2	1
Pre-PUA domain	PUA domain-like	2	1
HR1 repeat	Protein kinase-like (PK-like)	2	1
Zn-dependent exopeptidases	Zn-dependent exopeptidases	2	2
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	2	2
SH2 domain	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
Rudiment single hybrid motif	PurM C-terminal domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	2	1
Pentapeptide repeat-like	Pentapeptide repeat-like	2	2
S-adenosyl-L-methionine-dependent methyltransferases	Galactose oxidase, central domain	2	1
Cytochrome b5-like heme/steroid binding domain	Tudor/PWWP/MBT	2	1
S-adenosyl-L-methionine-dependent methyltransferases	NAD(P)-binding Rossmann-fold domains	2	1
Hairpin loop containing domain-like	SRCR-like	2	2
Glycoside hydrolase/deacetylase	Glycoside hydrolase/deacetylase	2	1
Voltage-gated potassium channels	EF-hand	2	1
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	2	1
Family A G protein-coupled receptor-like	"Winged helix" DNA-binding domain	2	1
Growth factor receptor domain	NHL repeat	2	1
UBC-like	Ribosomal protein S5 domain 2-like	2	1
Aldolase	Single hybrid motif	2	1
POZ domain	Ankyrin repeat	2	2
P-loop containing nucleoside triphosphate hydrolases	Second domain of FERM	2	2
Bromodomain	TAZ domain	2	2
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	2	2
TGS-like	Class II aaRS ABD-related	2	1
PreATP-grasp domain	post-HMGL domain-like	2	1
Ankyrin repeat	WD40 repeat-like	2	1
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	2	2
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	2	2
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	2	2
Galactose-binding domain-like	Growth factor receptor domain	2	2
Spectrin repeat	WW domain	2	2
PDZ domain-like	Formin homology 2 domain (FH2 domain)	2	2
Ubiquitin-like	Cysteine proteinases	2	2
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	2	2
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	2	1
HLH, helix-loop-helix DNA-binding domain	Formin homology 2 domain (FH2 domain)	2	2
EF-hand	SH2 domain	2	2
E set domains	AMPKBI-like	2	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	Quinoprotein alcohol dehydrogenase-like	2	2
HCP-like	HCP-like	2	2
Probable ACP-binding domain of malonyl-CoA ACP transacylase	ACP-like	2	1
Thiolase-like	alpha/beta-Hydrolases	2	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	2	1
SET domain	RuBisCo LSMT C-terminal, substrate-binding domain	2	2
PurM N-terminal domain-like	Class I glutamine amidotransferase-like	2	1
Thiolase-like	FabD/lysophospholipase-like	2	1
Protein kinase-like (PK-like)	UBA-like	2	2
Trypsin-like serine proteases	Trypsin-like serine proteases	2	2
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	2	1
Plexin repeat	Integrin beta tail domain	2	1
Actin depolymerizing proteins	VHP, Villin headpiece domain	2	2
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	2	1
Thyroglobulin type-1 domain	Thyroglobulin type-1 domain	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	2	1
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	2	2
GST C-terminal domain-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Thiolase-like	ACP-like	2	1
Granulin repeat	Granulin repeat	2	2
FYVE/PHD zinc finger	Supernatant protein factor (SPF), C-terminal domain	2	1
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	2	1
PAP/OAS1 substrate-binding domain	Retrovirus zinc finger-like domains	2	1
Tudor/PWWP/MBT	Staphylococcal nuclease	2	2
Cytochrome b5-like heme/steroid binding domain	Hect, E3 ligase catalytic domain	2	1
ARM repeat	L domain-like	2	1
Tricorn protease domain 2	SOCS box-like	2	1
DNase I-like	RNA-binding domain, RBD	2	1
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, dispensable insert domain	2	1
ADC-like	Cdc48 domain 2-like	2	1
PDZ domain-like	Second domain of FERM	2	1
FYVE/PHD zinc finger	SAM/Pointed domain	2	1
TPR-like	Clavaminate synthase-like	2	2
Tudor/PWWP/MBT	S-adenosyl-L-methionine-dependent methyltransferases	2	1
SET domain	WW domain	2	1
Ankyrin repeat	Second domain of FERM	2	1
NAD kinase/diacylglycerol kinase-like	SAM/Pointed domain	2	2
HR1 repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
Cytochrome b5-like heme/steroid binding domain	Mib/herc2 domain-like	2	1
Methyl-accepting chemotaxis protein (MCP) signaling domain	Concanavalin A-like lectins/glucanases	2	2
L domain-like	WD40 repeat-like	2	1
"Winged helix" DNA-binding domain	dsRNA-binding domain-like	2	2
"Winged helix" DNA-binding domain	FYVE/PHD zinc finger	2	2
Second domain of FERM	Protein kinase-like (PK-like)	2	2
Cysteine proteinases	Ribonuclease H-like	2	1
PurM C-terminal domain-like	Formyltransferase	2	1
SH2 domain	DNase I-like	2	1
ADC-like	P-loop containing nucleoside triphosphate hydrolases	2	1
TB module/8-cys domain	TB module/8-cys domain	2	2
GMP synthetase C-terminal dimerisation domain	GMP synthetase C-terminal dimerisation domain	2	1
Calcium-dependent phosphotriesterase	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	2
GTPase activation domain, GAP	VPS9 domain	2	1
Starch-binding domain-like	PLC-like phosphodiesterases	2	1
P-loop containing nucleoside triphosphate hydrolases	PAZ domain	2	1
LDL receptor-like module	FnI-like domain	2	2
EGF/Laminin	Di-copper centre-containing domain	2	1
PP2C-like	PP2C-like	2	2
Ankyrin repeat	Galactose-binding domain-like	2	2
Concanavalin A-like lectins/glucanases	SRCR-like	2	2
ACP-like	alpha/beta-Hydrolases	2	1
VPS9 domain	Ankyrin repeat	2	1
TSP-1 type 1 repeat	Hairpin loop containing domain-like	2	2
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	2	2
RCC1/BLIP-II	Cytochrome b5-like heme/steroid binding domain	2	1
Putative DNA-binding domain	SAND domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Quinoprotein alcohol dehydrogenase-like	2	2
L domain-like	NTF2-like	2	1
CHY zinc finger-like	RING/U-box	2	1
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	2	1
Cation efflux protein transmembrane domain-like	Cation efflux protein transmembrane domain-like	2	1
DEATH domain	Toll/Interleukin receptor TIR domain	2	2
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	2	2
TPR-like	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	2	2
RNA-binding domain, RBD	PWI domain	2	1
EF-hand	Mannose 6-phosphate receptor domain	2	2
L domain-like	Concanavalin A-like lectins/glucanases	2	2
alpha-helical ferredoxin	Nucleotide-binding domain	2	2
Carbamate kinase-like	ALDH-like	2	1
RUN domain-like	Supernatant protein factor (SPF), C-terminal domain	2	1
S-adenosyl-L-methionine-dependent methyltransferases	alpha/beta-Hydrolases	2	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	2	1
P-loop containing nucleoside triphosphate hydrolases	RNase III domain-like	2	1
Ypt/Rab-GAP domain of gyp1p	WD40 repeat-like	2	2
Ubiquitin-like	Ankyrin repeat	2	2
PH domain-like	FAT domain of focal adhesion kinase	2	2
CHY zinc finger-like	Zinc hairpin stack	2	1
vWA-like	Complement control module/SCR domain	2	2
EF-hand	PX domain	2	1
Galactose-binding domain-like	TSP-1 type 1 repeat	2	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipase/lipooxygenase domain (PLAT/LH2 domain)	2	2
Growth factor receptor domain	TSP-1 type 1 repeat	2	2
p53-like transcription factors	Ankyrin repeat	2	1
post-HMGL domain-like	Single hybrid motif	2	1
Bromodomain	Nuclear receptor coactivator interlocking domain	2	2
ARM repeat	RING/U-box	2	2
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	2	1
Restriction endonuclease-like	RuvA domain 2-like	2	1
DNA breaking-rejoining enzymes	Eukaryotic DNA topoisomerase I, dispensable insert domain	2	1
HAD-like	HAD-like	2	2
UBA-like	RNA-binding domain, RBD	2	1
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
Fibrinogen C-terminal domain-like	Growth factor receptor domain	2	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	2	1
Macro domain-like	RING/U-box	2	2
Thiolase-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
RING/U-box	TAZ domain	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	1
POZ domain	TRAF domain-like	2	2
PreATP-grasp domain	Aldolase	2	1
RNA-binding domain, RBD	HIT/MYND zinc finger-like	2	1
TSP type-3 repeat	TSP type-3 repeat	2	2
CAD & PB1 domains	Cysteine-rich domain	2	1
MIT domain	MIT domain	2	2
BRCT domain	WGR domain-like	2	2
Plexin repeat	GTPase activation domain, GAP	2	2
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	2	1
PH domain-like	Moesin tail domain	2	1
ARM repeat	WWE domain	2	2
C-type lectin-like	EGF/Laminin	2	2
Aconitase iron-sulfur domain	LeuD/IlvD-like	2	1
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	2	1
Ribonuclease H-like	RuvA domain 2-like	2	2
cAMP-binding domain-like	Ubiquitin-like	2	2
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	1
Nucleotidyltransferase	Nucleotidyltransferase	2	1
Rudiment single hybrid motif	PurM N-terminal domain-like	2	1
Glucocorticoid receptor-like (DNA-binding domain)	SET domain	2	1
Single hybrid motif	Single hybrid motif	2	2
PDZ domain-like	BAR/IMD domain-like	2	1
PX domain	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	2
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	2	2
L domain-like	EGF/Laminin	2	2
PUA domain-like	RING/U-box	2	2
TSP-1 type 1 repeat	Trypsin-like serine proteases	2	1
L domain-like	Actin depolymerizing proteins	2	1
HMA, heavy metal-associated domain	HAD-like	2	2
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	2	1
P-loop containing nucleoside triphosphate hydrolases	RNA-binding domain, RBD	2	2
LDL receptor-like module	L domain-like	2	2
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	2	2
Probable ACP-binding domain of malonyl-CoA ACP transacylase	S-adenosyl-L-methionine-dependent methyltransferases	2	1
PreATP-grasp domain	PurM N-terminal domain-like	2	1
SH2 domain	Cysteine-rich domain	2	2
E set domains	Alpha-macroglobulin receptor domain	2	1
Ankyrin repeat	Hect, E3 ligase catalytic domain	2	2
GroES-like	alpha/beta-Hydrolases	2	1
YWTD domain	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	2
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	2	2
LDL receptor-like module	Terpenoid cyclases/Protein prenyltransferases	2	1
BPTI-like	Di-copper centre-containing domain	2	1
Heat shock protein 70kD (HSP70), C-terminal subdomain	Heat shock protein 70kD (HSP70), C-terminal subdomain	2	1
RuvA domain 2-like	P-loop containing nucleoside triphosphate hydrolases	2	2
FabD/lysophospholipase-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Integrin domains	Integrin beta tail domain	2	1
Class II aaRS and biotin synthetases	Translation proteins	2	1
Tudor/PWWP/MBT	NAD(P)-binding Rossmann-fold domains	2	1
Toll/Interleukin receptor TIR domain	SAM/Pointed domain	2	2
L domain-like	DEATH domain	2	2
TPR-like	Chaperone J-domain	2	2
Metalloproteases ("zincins"), catalytic domain	Complement control module/SCR domain	2	2
Rudiment single hybrid motif	Formyltransferase	2	1
PreATP-grasp domain	PurM C-terminal domain-like	2	1
C2 domain (Calcium/lipid-binding domain, CaLB)	C-terminal domain of PLC-beta	2	2
PurM N-terminal domain-like	Formyltransferase	2	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	alpha/beta-Hydrolases	2	1
FabD/lysophospholipase-like	GroES-like	2	1
BRCT domain	Ankyrin repeat	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Smc hinge domain	2	1
vWA-like	Integrin beta tail domain	2	1
Eukaryotic type KH-domain (KH-domain type I)	Tudor/PWWP/MBT	2	2
Actin-crosslinking proteins	Actin-crosslinking proteins	2	2
Bromodomain	RING/U-box	2	2
Calpain large subunit, middle domain (domain III)	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
LDL receptor-like module	Hairpin loop containing domain-like	2	2
Glutathione synthetase ATP-binding domain-like	PurM N-terminal domain-like	2	1
Kazal-type serine protease inhibitors	Concanavalin A-like lectins/glucanases	2	1
Concanavalin A-like lectins/glucanases	EF-hand	2	1
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	2	2
Initiation factor IF2/eIF5b, domain 3	Translation proteins	2	2
MIT domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	2	1
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	2	2
RNI-like	Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain	2	1
E set domains	Protein kinase-like (PK-like)	2	2
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	2	2
WW domain	PIN domain-like	2	1
E set domains	GTPase activation domain, GAP	2	2
GroES-like	ACP-like	2	1
FMN-linked oxidoreductases	Nucleotide-binding domain	2	2
Thiolase-like	NAD(P)-binding Rossmann-fold domains	2	1
Avidin/streptavidin	Avidin/streptavidin	2	1
Spectrin repeat	RING/U-box	2	2
Cysteine proteinases	beta-sandwich domain of Sec23/24	2	2
Stathmin	Stathmin	2	1
PLC-like phosphodiesterases	C-terminal domain of PLC-beta	2	2
Second domain of FERM	FAT domain of focal adhesion kinase	2	2
YWTD domain	Fibronectin type III	2	2
HLH, helix-loop-helix DNA-binding domain	HMG-box	2	2
Kelch motif	EGF/Laminin	2	2
RUN domain-like	FYVE/PHD zinc finger	2	1
E set domains	DEATH domain	2	1
FabD/lysophospholipase-like	EF-hand	2	2
Hairpin loop containing domain-like	Trypsin-like serine proteases	2	2
Folate-binding domain	Aminomethyltransferase beta-barrel domain	2	2
BRCT domain	Domain of poly(ADP-ribose) polymerase	2	2
beta-beta-alpha zinc fingers	WW domain	2	1
RCC1/BLIP-II	Mib/herc2 domain-like	2	1
CCHHC domain	CCHHC domain	2	1
Metalloproteases ("zincins"), catalytic domain	EGF/Laminin	2	1
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	2	2
FabD/lysophospholipase-like	alpha/beta-Hydrolases	2	1
L domain-like	SAM/Pointed domain	2	1
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	2	1
FMN-linked oxidoreductases	alpha-helical ferredoxin	2	2
Cysteine proteinases	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
PurM N-terminal domain-like	PurM N-terminal domain-like	2	1
Cytochrome b5-like heme/steroid binding domain	RING/U-box	2	1
NAD(P)-binding Rossmann-fold domains	SCP-like	2	2
DNase I-like	SAM/Pointed domain	2	1
DBL homology domain (DH-domain)	BAR/IMD domain-like	2	2
P-loop containing nucleoside triphosphate hydrolases	LigT-like	2	1
Glutathione synthetase ATP-binding domain-like	post-HMGL domain-like	2	1
TAZ domain	Nuclear receptor coactivator interlocking domain	2	2
RCC1/BLIP-II	Tudor/PWWP/MBT	2	1
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	2	2
Clathrin heavy-chain terminal domain	ARM repeat	2	1
Kazal-type serine protease inhibitors	EGF/Laminin	2	1
Glutathione synthetase ATP-binding domain-like	Formyltransferase	2	1
SMAD MH1 domain	SMAD/FHA domain	2	1
vWA-like	Invertebrate chitin-binding proteins	2	2
Glutathione synthetase ATP-binding domain-like	PurM C-terminal domain-like	2	1
LDL receptor-like module	Alpha-macroglobulin receptor domain	2	1
Polo-box domain	Polo-box domain	2	1
DBL homology domain (DH-domain)	Ras GEF	2	2
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	2	2
Sema domain	Protein kinase-like (PK-like)	2	2
Sema domain	E set domains	2	2
Translational machinery components	L30e-like	2	2
Zinc beta-ribbon	Cyclin-like	2	2
HAD-like	FAD/NAD(P)-binding domain	2	2
Aldolase	post-HMGL domain-like	2	1
NAD(P)-binding Rossmann-fold domains	P-loop containing nucleoside triphosphate hydrolases	2	2
RCC1/BLIP-II	DBL homology domain (DH-domain)	2	1
Galactose-binding domain-like	(Phosphotyrosine protein) phosphatases II	2	2
S-adenosyl-L-methionine-dependent methyltransferases	ACP-like	2	1
Saposin	Saposin	2	2
Metallo-dependent phosphatases	EF-hand	2	1
Quinoprotein alcohol dehydrogenase-like	TPR-like	2	1
HR1 repeat	HR1 repeat	2	1
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	2	1
Plexin repeat	Protein kinase-like (PK-like)	2	2
Enolase N-terminal domain-like	Enolase C-terminal domain-like	2	2
PurM C-terminal domain-like	PurM C-terminal domain-like	2	1
RING/U-box	Protein kinase-like (PK-like)	2	1
RNI-like	RNI-like	2	2
PAZ domain	dsRNA-binding domain-like	2	1
WD40 repeat-like	Ribonuclease H-like	2	1
Invertebrate chitin-binding proteins	Glycoside hydrolase/deacetylase	2	2
WD40 repeat-like	FYVE/PHD zinc finger	2	2
WD40 repeat-like	NHL repeat	2	2
Tex N-terminal region-like	Ribonuclease H-like	2	2
RNA-binding domain, RBD	PABC (PABP) domain	2	1
P-loop containing nucleoside triphosphate hydrolases	DEATH domain	2	2
Protein kinase-like (PK-like)	MIT domain	2	2
LDL receptor-like module	EF-hand	2	2
SH3-domain	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	2	1
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	2	1
Protein kinase-like (PK-like)	RNA-binding domain, RBD	2	1
p53-like transcription factors	DEATH domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Myosin rod fragments	2	2
EGF/Laminin	BPTI-like	2	1
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	2	2
L domain-like	RING/U-box	2	1
WD40 repeat-like	Cysteine proteinases	2	1
FKBP-like	Myosin rod fragments	2	1
LDL receptor-like module	Mannose 6-phosphate receptor domain	2	2
ARM repeat	Rap/Ran-GAP	2	2
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	2	1
Glutathione synthetase ATP-binding domain-like	Aldolase	2	1
Voltage-gated potassium channels	Small-conductance potassium channel	2	1
Eukaryotic type KH-domain (KH-domain type I)	P-loop containing nucleoside triphosphate hydrolases	2	1
Cysteine proteinases	Galactose-binding domain-like	2	2
Thiolase-like	GroES-like	2	1
BRCT domain	ADP-ribosylation	2	2
Zinc hairpin stack	RING/U-box	2	1
UBC-like	Endosomal sorting complex assembly domain	2	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	2	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	VPS9 domain	2	1
Rudiment single hybrid motif	post-HMGL domain-like	2	1
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	2	2
Nucleotidylyl transferase	Ribosomal protein L25-like	2	2
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	2	1
NTF2-like	NTF2-like	2	1
TPR-like	"Winged helix" DNA-binding domain	2	2
PAZ domain	RNase III domain-like	2	1
PAP/OAS1 substrate-binding domain	PAP/OAS1 substrate-binding domain	2	1
PRTase-like	PRTase-like	2	2
L domain-like	Snake toxin-like	2	2
C-type lectin-like	Complement control module/SCR domain	2	2
Nucleotidyltransferase	Retrovirus zinc finger-like domains	2	1
FabD/lysophospholipase-like	NAD(P)-binding Rossmann-fold domains	2	1
B-box zinc-binding domain	TRAF domain-like	2	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	GroES-like	2	1
Growth factor receptor domain	FnI-like domain	2	2
Serine protease inhibitors	Hairpin loop containing domain-like	2	2
ThrRS/AlaRS common domain	Class II aaRS ABD-related	2	1
Thioredoxin-like	"Winged helix" DNA-binding domain	1	1
PA domain	RING/U-box	1	1
WWE domain	Hect, E3 ligase catalytic domain	1	1
F-box domain	Sec7 domain	1	1
Serine protease inhibitors	EGF/Laminin	1	1
Kazal-type serine protease inhibitors	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
N-terminal domain of cbl (N-cbl)	EF-hand	1	1
Pseudouridine synthase	PUA domain-like	1	1
FYVE/PHD zinc finger	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
SMAD/FHA domain	HAD-like	1	1
Ubiquitin-like	PUA domain-like	1	1
DNA/RNA polymerases	L domain-like	1	1
Homocysteine S-methyltransferase	Cobalamin (vitamin B12)-binding domain	1	1
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain	WD40 repeat-like	1	1
Histone-fold	Ras GEF	1	1
SAP domain	Concanavalin A-like lectins/glucanases	1	1
Glycerol-3-phosphate (1)-acyltransferase	EF-hand	1	1
PH domain-like	Phospholipase D/nuclease	1	1
beta-beta-alpha zinc fingers	P-loop containing nucleoside triphosphate hydrolases	1	1
Ribosomal protein L25-like	Class II aaRS ABD-related	1	1
Kringle-like	(Phosphotyrosine protein) phosphatases II	1	1
SAICAR synthase-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
Rhodanese/Cell cycle control phosphatase	Cysteine proteinases	1	1
SAM/Pointed domain	P-loop containing nucleoside triphosphate hydrolases	1	1
RUN domain-like	PH domain-like	1	1
Heme-dependent peroxidases	EF-hand	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain III	1	1
SH3-domain	WW domain	1	1
Cyclophilin-like	RNA-binding domain, RBD	1	1
Galactose-binding domain-like	Kelch motif	1	1
Formin homology 2 domain (FH2 domain)	RING/U-box	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain I	1	1
Growth factor receptor domain	Notch domain	1	1
ENTH/VHS domain	SH3-domain	1	1
Tricorn protease domain 2	RCC1/BLIP-II	1	1
RING/U-box	RNA-binding domain, RBD	1	1
WWE domain	WWE domain	1	1
Histone-fold	PH domain-like	1	1
ARM repeat	CYTH-like phosphatases	1	1
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	1	1
SMAD/FHA domain	PDZ domain-like	1	1
DNA/RNA polymerases	Zinc finger domain of DNA polymerase-alpha	1	1
WD40 repeat-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
Macro domain-like	CRAL/TRIO domain	1	1
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	1	1
YccV-like	ApaG-like	1	1
SH3-domain	SAM/Pointed domain	1	1
GST C-terminal domain-like	eEF1-gamma domain	1	1
"Winged helix" DNA-binding domain	GroEL apical domain-like	1	1
Rhodanese/Cell cycle control phosphatase	WW domain	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	1	1
Kazal-type serine protease inhibitors	Immunoglobulin	1	1
WD40 repeat-like	DPP6 N-terminal domain-like	1	1
Protein kinase-like (PK-like)	BEACH domain	1	1
Acyl-CoA binding protein	Ankyrin repeat	1	1
Amyloid beta a4 protein copper binding domain (domain 2)	CAPPD, an extracellular domain of amyloid beta A4 protein	1	1
Immunoglobulin	Caspase-like	1	1
RNI-like	ARM repeat	1	1
HAD-like	P-loop containing nucleoside triphosphate hydrolases	1	1
HR1 repeat	PDZ domain-like	1	1
PR-1-like	PR-1-like	1	1
Prokaryotic type I DNA topoisomerase	Zinc beta-ribbon	1	1
DBL homology domain (DH-domain)	FYVE/PHD zinc finger	1	1
DNase I-like	Formin homology 2 domain (FH2 domain)	1	1
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	Formin homology 2 domain (FH2 domain)	1	1
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	1	1
F-box domain	ApaG-like	1	1
POZ domain	WD40 repeat-like	1	1
E set domains	Pectin lyase-like	1	1
Second domain of FERM	(Phosphotyrosine protein) phosphatases II	1	1
Nucleic acid-binding proteins	Retrovirus zinc finger-like domains	1	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Pyrimidine nucleoside phosphorylase C-terminal domain	1	1
ENTH/VHS domain	FYVE/PHD zinc finger	1	1
PA domain	Transferrin receptor-like dimerisation domain	1	1
WW domain	PH domain-like	1	1
POZ domain	Galactose-binding domain-like	1	1
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	1	1
Thioesterase/thiol ester dehydrase-isomerase	SCP-like	1	1
PheT/TilS domain	Class II aaRS and biotin synthetases	1	1
ClpS-like	"Winged helix" DNA-binding domain	1	1
Carbonic anhydrase	Carbonic anhydrase	1	1
EF-hand	Dimeric alpha+beta barrel	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
P-loop containing nucleoside triphosphate hydrolases	SMR domain-like	1	1
GroES-like	GroES-like	1	1
Adenine nucleotide alpha hydrolases-like	YjgF-like	1	1
lambda repressor-like DNA-binding domains	lambda repressor-like DNA-binding domains	1	1
Cytochrome b5-like heme/steroid binding domain	HSP20-like chaperones	1	1
TRAF domain-like	PDZ domain-like	1	1
UBA-like	DNase I-like	1	1
Cysteine proteinases	Tudor/PWWP/MBT	1	1
Ribonuclease H-like	Zinc finger domain of DNA polymerase-alpha	1	1
Immunoglobulin	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
Notch domain	Notch domain	1	1
ARM repeat	POZ domain	1	1
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	1	1
Carboxypeptidase regulatory domain-like	Carboxypeptidase regulatory domain-like	1	1
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	1	1
alpha/beta knot	Nucleic acid-binding proteins	1	1
TPR-like	PUA domain-like	1	1
PUG domain-like	Ubiquitin-like	1	1
PH domain-like	Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	1	1
PH domain-like	RING/U-box	1	1
Histone-fold	Histone-fold	1	1
Fibronectin type III	Thioredoxin-like	1	1
Homocysteine S-methyltransferase	Methionine synthase activation domain-like	1	1
Calcium-dependent phosphotriesterase	SOCS box-like	1	1
Galactose oxidase, central domain	Galactose oxidase, central domain	1	1
PUG domain-like	Cysteine proteinases	1	1
Complement control module/SCR domain	SRCR-like	1	1
BRCT domain	Nucleotidyltransferase	1	1
G protein-binding domain	Cysteine-rich domain	1	1
Retrovirus zinc finger-like domains	DNA/RNA polymerases	1	1
Ankyrin repeat	EF-hand	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
dsRNA-binding domain-like	R3H domain	1	1
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	1	1
PH domain-like	BSD domain-like	1	1
FabD/lysophospholipase-like	FabD/lysophospholipase-like	1	1
TROVE domain-like	vWA-like	1	1
S15/NS1 RNA-binding domain	C-terminal domain of ProRS	1	1
Calcium-dependent phosphotriesterase	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
DBL homology domain (DH-domain)	SH2 domain	1	1
Tudor/PWWP/MBT	Chromo domain-like	1	1
Histone-fold	Macro domain-like	1	1
YjgF-like	YjgF-like	1	1
RNA-binding domain, RBD	dsRNA-binding domain-like	1	1
DNA/RNA polymerases	ARM repeat	1	1
SH3-domain	Plakin repeat	1	1
Invertebrate chitin-binding proteins	E set domains	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Hect, E3 ligase catalytic domain	1	1
POZ domain	Skp1 dimerisation domain-like	1	1
SH2 domain	PLC-like phosphodiesterases	1	1
PX domain	GTPase activation domain, GAP	1	1
Ubiquitin-like	HAD-like	1	1
Hypothetical protein SAV1430	Fe-S cluster assembly (FSCA) domain-like	1	1
BAR/IMD domain-like	SH2 domain	1	1
Bet v1-like	Bet v1-like	1	1
RING/U-box	beta-sandwich domain of Sec23/24	1	1
GST C-terminal domain-like	Class II aaRS and biotin synthetases	1	1
SH2 domain	Ras GEF	1	1
TPR-like	RING/U-box	1	1
Quinoprotein alcohol dehydrogenase-like	UBC-like	1	1
PUA domain-like	SWIB/MDM2 domain	1	1
Acyl-CoA binding protein	ClpP/crotonase	1	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	NHL repeat	1	1
Cytochrome b5-like heme/steroid binding domain	Riboflavin synthase domain-like	1	1
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	1	1
Dihydropteroate synthetase-like	Methionine synthase activation domain-like	1	1
SMAD/FHA domain	Protein kinase-like (PK-like)	1	1
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	1	1
Kelch motif	Galactose oxidase, central domain	1	1
L domain-like	ADP-ribosylation	1	1
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
FYVE/PHD zinc finger	GroEL apical domain-like	1	1
ArfGap/RecO-like zinc finger	Family A G protein-coupled receptor-like	1	1
Alpha subunit of glutamate synthase, C-terminal domain	Nucleotide-binding domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	beta-beta-alpha zinc fingers	1	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	1	1
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	1	1
Ankyrin repeat	(Trans)glycosidases	1	1
RNI-like	Trypsin-like serine proteases	1	1
Kringle-like	Concanavalin A-like lectins/glucanases	1	1
Ribosomal protein L25-like	S15/NS1 RNA-binding domain	1	1
GST C-terminal domain-like	C-terminal domain of ProRS	1	1
Tricorn protease domain 2	WD40 repeat-like	1	1
C-type lectin-like	Fibronectin type III	1	1
Protein kinase-like (PK-like)	Ypt/Rab-GAP domain of gyp1p	1	1
ClpP/crotonase	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
E set domains	Hect, E3 ligase catalytic domain	1	1
PUA domain-like	Nucleotidylyl transferase	1	1
Quinoprotein alcohol dehydrogenase-like	DPP6 N-terminal domain-like	1	1
Concanavalin A-like lectins/glucanases	Fibrinogen C-terminal domain-like	1	1
NAD kinase/diacylglycerol kinase-like	NAD kinase/diacylglycerol kinase-like	1	1
Tex N-terminal region-like	SH2 domain	1	1
P-loop containing nucleoside triphosphate hydrolases	R3H domain	1	1
DBL homology domain (DH-domain)	WD40 repeat-like	1	1
"Winged helix" DNA-binding domain	GTPase activation domain, GAP	1	1
Aminoacid dehydrogenase-like, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Eukaryotic type KH-domain (KH-domain type I)	SAM/Pointed domain	1	1
USP8 N-terminal domain-like	Rhodanese/Cell cycle control phosphatase	1	1
beta-beta-alpha zinc fingers	TRAF domain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	1	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	1	1
Apolipoprotein A-I	Apolipoprotein A-I	1	1
Nucleic acid-binding proteins	TPR-like	1	1
Calponin-homology domain, CH-domain	Ubiquitin-like	1	1
Protein kinase-like (PK-like)	KA1-like	1	1
Glycosyl hydrolase domain	Glycosyl hydrolase domain	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
HBS1-like domain	Translation proteins	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	LDL receptor-like module	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
GFP-like	EGF/Laminin	1	1
GTPase activation domain, GAP	RGC domain-like	1	1
EF-hand	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	E set domains	1	1
F-box domain	YccV-like	1	1
P-loop containing nucleoside triphosphate hydrolases	POZ domain	1	1
Serine protease inhibitors	Growth factor receptor domain	1	1
Frizzled cysteine-rich domain	LDL receptor-like module	1	1
Lipovitellin-phosvitin complex, superhelical domain	vWA-like	1	1
Periplasmic binding protein-like II	Nucleotide cyclase	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
FAD-linked reductases, C-terminal domain	Aminomethyltransferase beta-barrel domain	1	1
Ribonuclease H-like	Ribonuclease H-like	1	1
RNA-binding domain, RBD	beta-sandwich domain of Sec23/24	1	1
Serine protease inhibitors	vWA-like	1	1
Zinc beta-ribbon	Zinc beta-ribbon	1	1
Inhibitor of apoptosis (IAP) repeat	UBC-like	1	1
RING/U-box	DEATH domain	1	1
TRAF domain-like	NRDP1 C-terminal domain-like	1	1
PDZ domain-like	EF-hand	1	1
DNA-binding domain	FYVE/PHD zinc finger	1	1
GST C-terminal domain-like	Ribosomal protein L25-like	1	1
CoA-dependent acyltransferases	Formin homology 2 domain (FH2 domain)	1	1
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	cAMP-binding domain-like	1	1
DAK1/DegV-like	DhaL-like	1	1
Calcyclin-binding protein-like	HSP20-like chaperones	1	1
GFP-like	Growth factor receptor domain	1	1
Formin homology 2 domain (FH2 domain)	SAM/Pointed domain	1	1
NAD(P)-binding Rossmann-fold domains	RING/U-box	1	1
GST C-terminal domain-like	eEF-1beta-like	1	1
"Winged helix" DNA-binding domain	occludin/ELL-like	1	1
Galactose mutarotase-like	Glycosyl hydrolase domain	1	1
LDL receptor-like module	Fibronectin type III	1	1
TSP-1 type 1 repeat	Concanavalin A-like lectins/glucanases	1	1
DBL homology domain (DH-domain)	Quinoprotein alcohol dehydrogenase-like	1	1
SH3-domain	PLC-like phosphodiesterases	1	1
beta-beta-alpha zinc fingers	Phage fibre proteins	1	1
PRP4-like	WD40 repeat-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Fzo-like conserved region	1	1
Homeodomain-like	Creatinase/aminopeptidase	1	1
DNase I-like	GTPase activation domain, GAP	1	1
Quinoprotein alcohol dehydrogenase-like	EF-hand	1	1
ARM repeat	EGF/Laminin	1	1
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	1	1
Mib/herc2 domain-like	Spermadhesin, CUB domain	1	1
Soluble quinoprotein glucose dehydrogenase	RING/U-box	1	1
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	1	1
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	1	1
DNA breaking-rejoining enzymes	POZ domain	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	vWA-like	1	1
PDZ domain-like	"Winged helix" DNA-binding domain	1	1
Galactose-binding domain-like	Concanavalin A-like lectins/glucanases	1	1
beta-sandwich domain of Sec23/24	Protein kinase-like (PK-like)	1	1
R3H domain	Ribonuclease H-like	1	1
Chaperone J-domain	Homeodomain-like	1	1
CBS-domain pair	CBS-domain pair	1	1
Oxidoreductase molybdopterin-binding domain	E set domains	1	1
S15/NS1 RNA-binding domain	S15/NS1 RNA-binding domain	1	1
EGF/Laminin	TSP type-3 repeat	1	1
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	1	1
RNA-binding domain, RBD	DPP6 N-terminal domain-like	1	1
ARM repeat	HSP20-like chaperones	1	1
TPR-like	Metallo-dependent phosphatases	1	1
N-terminal domain of cbl (N-cbl)	UBA-like	1	1
LDL receptor-like module	Family A G protein-coupled receptor-like	1	1
Ribonuclease H-like	SH2 domain	1	1
RING/U-box	DUSP-like	1	1
TSP type-3 repeat	Concanavalin A-like lectins/glucanases	1	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	1	1
Ubiquitin-like	NAD kinase/diacylglycerol kinase-like	1	1
PX domain	TPR-like	1	1
TNF receptor-like	TNF receptor-like	1	1
POZ domain	Pentapeptide repeat-like	1	1
beta-sandwich domain of Sec23/24	Formin homology 2 domain (FH2 domain)	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Nucleic acid-binding proteins	1	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	1	1
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	1	1
TAZ domain	Kix domain of CBP (creb binding protein)	1	1
Nucleotidylyl transferase	Class II aaRS and biotin synthetases	1	1
EGF/Laminin	Notch domain	1	1
RNA-binding domain, RBD	Eukaryotic type KH-domain (KH-domain type I)	1	1
Methionine synthase domain	Methionine synthase activation domain-like	1	1
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	Pyrimidine nucleoside phosphorylase C-terminal domain	1	1
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Ankyrin repeat	YWTD domain	1	1
PIN domain-like	Nucleic acid-binding proteins	1	1
Insect cysteine-rich antifreeze protein	Insect cysteine-rich antifreeze protein	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Sialidases	1	1
FMT C-terminal domain-like	ACP-like	1	1
Ribosomal protein S5 domain 2-like	HMG-box	1	1
Ubiquitin-like	AN1-like Zinc finger	1	1
TPR-like	Fic-like	1	1
vWA-like	Cysteine-rich domain	1	1
PHM/PNGase F	NHL repeat	1	1
Homocysteine S-methyltransferase	Methionine synthase domain	1	1
SAM/Pointed domain	E set domains	1	1
F-box domain	SMI1/KNR4-like	1	1
WW domain	Cysteine proteinases	1	1
Heme-dependent peroxidases	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
ARID-like	Chromo domain-like	1	1
FYVE/PHD zinc finger	EF-hand	1	1
Class II aaRS ABD-related	C-terminal domain of ProRS	1	1
Ankyrin repeat	TPR-like	1	1
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	1	1
Band 7/SPFH domain	SCP-like	1	1
F-box domain	Cyclin-like	1	1
UBA-like	XPC-binding domain	1	1
HLH, helix-loop-helix DNA-binding domain	beta-sandwich domain of Sec23/24	1	1
EGF/Laminin	Ankyrin repeat	1	1
Cytochrome b5-like heme/steroid binding domain	E set domains	1	1
ARM repeat	SAM/Pointed domain	1	1
Cystine-knot cytokines	Cystine-knot cytokines	1	1
UBA-like	WWE domain	1	1
BRCA2 helical domain	BRCA2 tower domain	1	1
MIT domain	Calpain large subunit, middle domain (domain III)	1	1
WD40 repeat-like	Nucleoporin domain	1	1
TSP-1 type 1 repeat	LDL receptor-like module	1	1
ENTH/VHS domain	Clathrin adaptor appendage domain	1	1
Homeodomain-like	Creatinase/prolidase N-terminal domain	1	1
BAR/IMD domain-like	Family A G protein-coupled receptor-like	1	1
Invertebrate chitin-binding proteins	Carbohydrate-binding domain	1	1
Kazal-type serine protease inhibitors	Protein kinase-like (PK-like)	1	1
EF-hand	Riboflavin synthase domain-like	1	1
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	1	1
Homocysteine S-methyltransferase	Dihydropteroate synthetase-like	1	1
WD40 repeat-like	Prefoldin	1	1
Nucleic acid-binding proteins	SH2 domain	1	1
Dom34/Pelota N-terminal domain-like	L30e-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
Heme-dependent peroxidases	Riboflavin synthase domain-like	1	1
RING/U-box	Fibronectin type III	1	1
NAD(P)-binding Rossmann-fold domains	DHS-like NAD/FAD-binding domain	1	1
Calponin-homology domain, CH-domain	Plakin repeat	1	1
ARM repeat	PX domain	1	1
BRCT domain	DBL homology domain (DH-domain)	1	1
RNA-binding domain, RBD	SPOC domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	SH2 domain	1	1
L domain-like	PP2C-like	1	1
Acetyl-CoA synthetase-like	Acetyl-CoA synthetase-like	1	1
Tudor/PWWP/MBT	SET domain	1	1
Chaperone J-domain	E set domains	1	1
P-loop containing nucleoside triphosphate hydrolases	DPP6 N-terminal domain-like	1	1
SH3-domain	Immunoglobulin	1	1
ACP-like	ALDH-like	1	1
HBS1-like domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Putative DNA-binding domain	1	1
SH3-domain	UBA-like	1	1
PLP-dependent transferases	PLP-dependent transferases	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
Sema domain	Immunoglobulin	1	1
Cytochrome b5-like heme/steroid binding domain	Oxidoreductase molybdopterin-binding domain	1	1
ARID-like	ARM repeat	1	1
ARM repeat	Fibronectin type III	1	1
Cu,Zn superoxide dismutase-like	Cu,Zn superoxide dismutase-like	1	1
HSP20-like chaperones	Riboflavin synthase domain-like	1	1
Protease propeptides/inhibitors	Subtilisin-like	1	1
BRCT domain	DNA/RNA polymerases	1	1
Histone-fold	DBL homology domain (DH-domain)	1	1
TATA-box binding protein-like	TATA-box binding protein-like	1	1
Ankyrin repeat	beta-N-acetylhexosaminidase-like domain	1	1
Macro domain-like	ADP-ribosylation	1	1
BRCT domain	Homeodomain-like	1	1
TSP-1 type 1 repeat	GFP-like	1	1
Calponin-homology domain, CH-domain	RGC domain-like	1	1
Clavaminate synthase-like	EF-hand	1	1
PH domain-like	Family A G protein-coupled receptor-like	1	1
TPR-like	Toll/Interleukin receptor TIR domain	1	1
RNA-binding domain, RBD	Formin homology 2 domain (FH2 domain)	1	1
FYVE/PHD zinc finger	Elongation factor TFIIS domain 2	1	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	1	1
Tudor/PWWP/MBT	CCHHC domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
C-type lectin-like	Growth factor receptor domain	1	1
Ribonuclease H-like	HRDC-like	1	1
RING/U-box	WWE domain	1	1
RuvA domain 2-like	Nucleic acid-binding proteins	1	1
Kazal-type serine protease inhibitors	L domain-like	1	1
Invertebrate chitin-binding proteins	beta-N-acetylhexosaminidase-like domain	1	1
ALDH-like	ALDH-like	1	1
AF1104-like	AF1104-like	1	1
Growth factor receptor domain	Fibronectin type III	1	1
NTF2-like	RNA-binding domain, RBD	1	1
EGF/Laminin	Trypsin-like serine proteases	1	1
Methylglyoxal synthase-like	Cytidine deaminase-like	1	1
PKD domain	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
EF-hand	C-terminal domain of PLC-beta	1	1
Protease propeptides/inhibitors	Zn-dependent exopeptidases	1	1
PRTase-like	Ribulose-phoshate binding barrel	1	1
FYVE/PHD zinc finger	BRK domain-like	1	1
dsRNA-binding domain-like	Tudor/PWWP/MBT	1	1
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
Leukotriene A4 hydrolase N-terminal domain	Leukotriene A4 hydrolase N-terminal domain	1	1
Nucleotidylyl transferase	Class II aaRS ABD-related	1	1
Kelch motif	Growth factor receptor domain	1	1
PUA domain-like	eIF1-like	1	1
CRAL/TRIO domain	GTPase activation domain, GAP	1	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
Heme-dependent peroxidases	FnI-like domain	1	1
PX domain	L domain-like	1	1
Chaperone J-domain	Sec63 N-terminal domain-like	1	1
ARM repeat	CalX-like	1	1
Kazal-type serine protease inhibitors	TSP-1 type 1 repeat	1	1
Ubiquitin-like	(Phosphotyrosine protein) phosphatases II	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	UBA-like	1	1
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Methenyltetrahydrofolate cyclohydrolase-like	1	1
Second domain of FERM	RING/U-box	1	1
YaeB-like	YaeB-like	1	1
BRK domain-like	Elongation factor TFIIS domain 2	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	1	1
"Winged helix" DNA-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Hedgehog/DD-peptidase	Hedgehog/DD-peptidase	1	1
cAMP-binding domain-like	PDZ domain-like	1	1
ISP transmembrane anchor	ISP domain	1	1
B-box zinc-binding domain	P-loop containing nucleoside triphosphate hydrolases	1	1
IP3 receptor type 1 binding core, domain 2	IP3 receptor type 1 binding core, domain 2	1	1
Immunoglobulin	Trypsin-like serine proteases	1	1
MIT domain	Cysteine proteinases	1	1
B-box zinc-binding domain	Fibronectin type III	1	1
Cna protein B-type domain	Starch-binding domain-like	1	1
PX domain	MIT domain	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
EF-hand	UBA-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ATP-dependent DNA ligase DNA-binding domain	1	1
FAD/NAD(P)-binding domain	Aminomethyltransferase beta-barrel domain	1	1
RNA-binding domain, RBD	Class II aaRS ABD-related	1	1
Alpha subunit of glutamate synthase, C-terminal domain	alpha-helical ferredoxin	1	1
BRCA2 helical domain	Nucleic acid-binding proteins	1	1
NAD(P)-binding Rossmann-fold domains	NagB/RpiA/CoA transferase-like	1	1
Trypsin-like serine proteases	PDZ domain-like	1	1
TSP-1 type 1 repeat	PMP inhibitors	1	1
Ribosomal protein L25-like	C-terminal domain of ProRS	1	1
A heparin-binding domain	Amyloid beta a4 protein copper binding domain (domain 2)	1	1
Staphylococcal nuclease	Staphylococcal nuclease	1	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	1	1
BRCT domain	DNA polymerase beta, N-terminal domain-like	1	1
Spectrin repeat	Immunoglobulin	1	1
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
Hypothetical protein c14orf129, hspc210	TPR-like	1	1
vWA-like	SPOC domain-like	1	1
TPR-like	RNA-binding domain, RBD	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	DEATH domain	1	1
RUN domain-like	PX domain	1	1
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	1	1
Activator of Hsp90 ATPase, Aha1	Bet v1-like	1	1
Snake toxin-like	Family A G protein-coupled receptor-like	1	1
beta-beta-alpha zinc fingers	Ribonuclease H-like	1	1
Acid proteases	ARM repeat	1	1
FAS1 domain	Growth factor receptor domain	1	1
Calponin-homology domain, CH-domain	P-loop containing nucleoside triphosphate hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	Chaperone J-domain	1	1
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	1	1
Thioredoxin-like	ERP29 C domain-like	1	1
vWA-like	Concanavalin A-like lectins/glucanases	1	1
RNA-binding domain, RBD	SET domain	1	1
Nucleic acid-binding proteins	BRCA2 tower domain	1	1
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	1	1
ADP-ribosylation	ADP-ribosylation	1	1
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	1	1
Homeodomain-like	L-aspartase-like	1	1
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	1	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	1	1
P-loop containing nucleoside triphosphate hydrolases	Cysteine-rich domain	1	1
Formate/glycerate dehydrogenase catalytic domain-like	DHS-like NAD/FAD-binding domain	1	1
Sema domain	TSP-1 type 1 repeat	1	1
SH2 domain	Ankyrin repeat	1	1
Periplasmic binding protein-like II	Protein kinase-like (PK-like)	1	1
Metalloproteases ("zincins"), catalytic domain	ARM repeat	1	1
MOSC N-terminal domain-like	PK beta-barrel domain-like	1	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	1	1
N-terminal domain of cbl (N-cbl)	SH2 domain	1	1
Nucleotide-diphospho-sugar transferases	SAM/Pointed domain	1	1
Formyltransferase	ALDH-like	1	1
HIT-like	HIT-like	1	1
DNase I-like	MFS general substrate transporter	1	1
HBS1-like domain	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Macro domain-like	1	1
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	1	1
Regulator of G-protein signaling, RGS	Ubiquitin-like	1	1
Ubiquitin-like	Zn-binding ribosomal proteins	1	1
Subtilisin-like	Growth factor receptor domain	1	1
(Trans)glycosidases	Six-hairpin glycosidases	1	1
Sialidases	Sialidases	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	YWTD domain	1	1
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	1	1
Protease propeptides/inhibitors	Galactose-binding domain-like	1	1
EF-hand	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
Sec63 N-terminal domain-like	Ribonuclease H-like	1	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	1	1
RuvA domain 2-like	F-box domain	1	1
cAMP-binding domain-like	FabD/lysophospholipase-like	1	1
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	1	1
Ankyrin repeat	Family A G protein-coupled receptor-like	1	1
UBC-like	UBA-like	1	1
FAD/NAD(P)-binding domain	EF-hand	1	1
EF-hand	Rhomboid-like	1	1
TPR-like	PIN domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	SOCS box-like	1	1
Hairpin loop containing domain-like	Concanavalin A-like lectins/glucanases	1	1
SAP domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Retrovirus capsid dimerization domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Bet v1-like	HAD-like	1	1
R3H domain	RNA-binding domain, RBD	1	1
FKBP-like	FKBP-like	1	1
RING/U-box	NRDP1 C-terminal domain-like	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
RING/U-box	SH3-domain	1	1
SH3-domain	Fibronectin type III	1	1
L domain-like	Trypsin-like serine proteases	1	1
DNA clamp	DNA clamp	1	1
SAM/Pointed domain	Hect, E3 ligase catalytic domain	1	1
Calponin-homology domain, CH-domain	GAS2 domain-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HMG-box	1	1
Tropomyosin	beta-beta-alpha zinc fingers	1	1
F-box domain	Concanavalin A-like lectins/glucanases	1	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	1	1
EF-hand	Isochorismatase-like hydrolases	1	1
Formyltransferase	ACP-like	1	1
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	1	1
AXH domain	HMG-box	1	1
DNA/RNA polymerases	FYVE/PHD zinc finger	1	1
Glucocorticoid receptor-like (DNA-binding domain)	VPS9 domain	1	1
Methionine synthase domain	Cobalamin (vitamin B12)-binding domain	1	1
Ypt/Rab-GAP domain of gyp1p	EF-hand	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	1	1
Soluble quinoprotein glucose dehydrogenase	SAM/Pointed domain	1	1
Sec63 N-terminal domain-like	DNA/RNA polymerases	1	1
PLP-dependent transferases	Adenine nucleotide alpha hydrolases-like	1	1
Growth factor receptor domain	(Phosphotyrosine protein) phosphatases II	1	1
vWA-like	TSP-1 type 1 repeat	1	1
RING/U-box	CCCH zinc finger	1	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	1	1
ENT-like	Bromodomain	1	1
FAD-linked reductases, C-terminal domain	Folate-binding domain	1	1
F-box domain	Kelch motif	1	1
P-loop containing nucleoside triphosphate hydrolases	Ribonuclease H-like	1	1
Galactose-binding domain-like	BRCT domain	1	1
Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	1	1
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	1	1
N-terminal domain of cbl (N-cbl)	RING/U-box	1	1
B-box zinc-binding domain	Tudor/PWWP/MBT	1	1
(Phosphotyrosine protein) phosphatases II	Nucleic acid-binding proteins	1	1
Integrin alpha N-terminal domain	Integrin alpha N-terminal domain	1	1
PLP-binding barrel	Alanine racemase C-terminal domain-like	1	1
PLC-like phosphodiesterases	PLC-like phosphodiesterases	1	1
Protein kinase-like (PK-like)	HCP-like	1	1
Starch-binding domain-like	Starch-binding domain-like	1	1
(Phosphotyrosine protein) phosphatases II	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
(Trans)glycosidases	Beta-D-glucan exohydrolase, C-terminal domain	1	1
Ankyrin repeat	HIT/MYND zinc finger-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Protein kinase-like (PK-like)	1	1
Thioredoxin-like	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
MIR domain	Concanavalin A-like lectins/glucanases	1	1
Ankyrin repeat	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	1	1
Ribonuclease H-like	CCCH zinc finger	1	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	1	1
FnI-like domain	Leech antihemostatic proteins	1	1
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	1	1
EPT/RTPC-like	RNA 3'-terminal phosphate cyclase, RPTC, insert domain	1	1
ARM repeat	HLH, helix-loop-helix DNA-binding domain	1	1
PLC-like phosphodiesterases	Ubiquitin-like	1	1
Calpain large subunit, middle domain (domain III)	Calpain large subunit, middle domain (domain III)	1	1
Kazal-type serine protease inhibitors	EF-hand	1	1
(Trans)glycosidases	(Trans)glycosidases	1	1
Thioredoxin-like	NHL repeat	1	1
WWE domain	ADP-ribosylation	1	1
Concanavalin A-like lectins/glucanases	RING/U-box	1	1
Ubiquitin-like	XPC-binding domain	1	1
EPT/RTPC-like	EPT/RTPC-like	1	1
SAM/Pointed domain	Ras GEF	1	1
CCHHC domain	SAM/Pointed domain	1	1
Thioredoxin-like	FAD/NAD(P)-binding domain	1	1
CCCH zinc finger	RNA-binding domain, RBD	1	1
Lipocalins	Lipocalins	1	1
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	1	1
Ligand-binding domain in the NO signalling and Golgi transport	Nucleotide cyclase	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Fibronectin type III	1	1
UBC-like	LigT-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
Thioredoxin-like	Galactose-binding domain-like	1	1
BAR/IMD domain-like	Protein kinase-like (PK-like)	1	1
NHL repeat	Calcium-dependent phosphotriesterase	1	1
RUN domain-like	PDZ domain-like	1	1
Galactose-binding domain-like	Protein kinase-like (PK-like)	1	1
Concanavalin A-like lectins/glucanases	SOCS box-like	1	1
USP8 N-terminal domain-like	WW domain	1	1
Tudor/PWWP/MBT	HIV integrase-binding domain	1	1
Regulator of G-protein signaling, RGS	Retrovirus zinc finger-like domains	1	1
Glucocorticoid receptor-like (DNA-binding domain)	beta-sandwich domain of Sec23/24	1	1
Cytochrome b5-like heme/steroid binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
HMA, heavy metal-associated domain	Cu,Zn superoxide dismutase-like	1	1
BRCT domain	post-AAA+ oligomerization domain-like	1	1
UBA-like	Tudor/PWWP/MBT	1	1
ARID-like	Clavaminate synthase-like	1	1
G protein-binding domain	PH domain-like	1	1
Ankyrin repeat	PDZ domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	1	1
Immunoglobulin	Heme-dependent peroxidases	1	1
MgtE membrane domain-like	MgtE membrane domain-like	1	1
Cadherin-like	Growth factor receptor domain	1	1
FYVE/PHD zinc finger	SMAD/FHA domain	1	1
TAFH domain-like	Histone-fold	1	1
FYVE/PHD zinc finger	PUA domain-like	1	1
Ribosomal protein L25-like	Class II aaRS and biotin synthetases	1	1
SRCR-like	C-type lectin-like	1	1
WWE domain	Domain of poly(ADP-ribose) polymerase	1	1
SMI1/KNR4-like	ApaG-like	1	1
Thiolase-like	SCP-like	1	1
Inhibitor of apoptosis (IAP) repeat	Quinoprotein alcohol dehydrogenase-like	1	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	1	1
Arp2/3 complex subunits	Arp2/3 complex subunits	1	1
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
GST C-terminal domain-like	Class II aaRS ABD-related	1	1
PH domain-like	C-terminal domain of PLC-beta	1	1
Protein kinase-like (PK-like)	Rhodanese/Cell cycle control phosphatase	1	1
Doublecortin (DC)	Ricin B-like lectins	1	1
PUG domain-like	Galactose-binding domain-like	1	1
Single hybrid motif	Formin homology 2 domain (FH2 domain)	1	1
Growth factor receptor domain	Ankyrin repeat	1	1
Translation proteins	Translation proteins	1	1
Immunoglobulin	FnI-like domain	1	1
Ankyrin repeat	FabD/lysophospholipase-like	1	1
beta-beta-alpha zinc fingers	ARM repeat	1	1
WD40 repeat-like	Cyclophilin-like	1	1
FAD/NAD(P)-binding domain	NAD(P)-binding Rossmann-fold domains	1	1
Dihydropteroate synthetase-like	Cobalamin (vitamin B12)-binding domain	1	1
beta-sandwich domain of Sec23/24	SET domain	1	1
Concanavalin A-like lectins/glucanases	Protein kinase-like (PK-like)	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	1	1
GAT-like domain	Clathrin adaptor appendage domain	1	1
DNA-glycosylase	Nudix	1	1
WW domain	FKBP-like	1	1
Ankyrin repeat	Formin homology 2 domain (FH2 domain)	1	1
Epsilon subunit of F1F0-ATP synthase N-terminal domain	Epsilon subunit of F1F0-ATP synthase C-terminal domain	1	1
Ankyrin repeat	RNI-like	1	1
USP8 N-terminal domain-like	Cysteine proteinases	1	1
Ankyrin repeat	Cap-Gly domain	1	1
Thioredoxin-like	eEF1-gamma domain	1	1
BEACH domain	FYVE/PHD zinc finger	1	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	1	1
SH2 domain	UBA-like	1	1
BSD domain-like	BSD domain-like	1	1
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	1	1
Galactose mutarotase-like	Galactose mutarotase-like	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Chromo domain-like	BRK domain-like	1	1
Ribonuclease H-like	Nucleic acid-binding proteins	1	1
Surp module (SWAP domain)	Ubiquitin-like	1	1
Plexin repeat	Immunoglobulin	1	1
p53-like transcription factors	SH2 domain	1	1
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Doublecortin (DC)	Protein kinase-like (PK-like)	1	1
THUMP domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
vWA-like	Sensory domain-like	1	1
BRK domain-like	BRK domain-like	1	1
F-box domain	UBC-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Microbial and mitochondrial ADK, insert "zinc finger" domain	1	1
Homeodomain-like	JAB1/MPN domain	1	1
FMT C-terminal domain-like	ALDH-like	1	1
"Winged helix" DNA-binding domain	beta-sandwich domain of Sec23/24	1	1
Ribonuclease H-like	RNA-binding domain, RBD	1	1
Acyl-CoA binding protein	Supernatant protein factor (SPF), C-terminal domain	1	1
CCHHC domain	Acyl-CoA N-acyltransferases (Nat)	1	1
Macro domain-like	BRCT domain	1	1
SIS domain	SIS domain	1	1
RuvA domain 2-like	SH2 domain	1	1
Ankyrin repeat	Domain of poly(ADP-ribose) polymerase	1	1
PYP-like sensor domain (PAS domain)	Protein kinase-like (PK-like)	1	1
TSP-1 type 1 repeat	BPTI-like	1	1
Plexin repeat	TSP-1 type 1 repeat	1	1
WD40 repeat-like	Bromodomain	1	1
Concanavalin A-like lectins/glucanases	FnI-like domain	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
HAD-like	Protein kinase-like (PK-like)	1	1
YWTD domain	Complement control module/SCR domain	1	1
FYVE/PHD zinc finger	Concanavalin A-like lectins/glucanases	1	1
PDZ domain-like	Ras GEF	1	1
A heparin-binding domain	CAPPD, an extracellular domain of amyloid beta A4 protein	1	1
Regulator of G-protein signaling, RGS	Protein kinase-like (PK-like)	1	1
BRCT domain	PsbU/PolX domain-like	1	1
FAD/NAD(P)-binding domain	Folate-binding domain	1	1
Family A G protein-coupled receptor-like	DEATH domain	1	1
Class II aaRS and biotin synthetases	GAD domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	AN1-like Zinc finger	1	1
Notch domain	Ankyrin repeat	1	1
R3H domain	AN1-like Zinc finger	1	1
SH3-domain	Phosphoglycerate mutase-like	1	1
CCCH zinc finger	Retrovirus zinc finger-like domains	1	1
GIY-YIG endonuclease	RING/U-box	1	1
Ankyrin repeat	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
Galactose-binding domain-like	EGF/Laminin	1	1
DNA-binding domain	SET domain	1	1
Plexin repeat	Plexin repeat	1	1
Ankyrin repeat	RCC1/BLIP-II	1	1
beta-beta-alpha zinc fingers	Leucine zipper domain	1	1
ARM repeat	Lipovitellin-phosvitin complex, superhelical domain	1	1
PEBP-like	PEBP-like	1	1
Nucleotidylyl transferase	Nucleotidylyl transferase	1	1
Rap/Ran-GAP	PDZ domain-like	1	1
BPTI-like	Immunoglobulin	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain II	1	1
Nqo1 middle domain-like	Nqo1C-terminal domain-like	1	1
ADP-ribosylation	Outer arm dynein light chain 1	1	1
Cobalamin (vitamin B12)-binding domain	Methionine synthase activation domain-like	1	1
CAD & PB1 domains	His-Me finger endonucleases	1	1
ARM repeat	Galactose-binding domain-like	1	1
SH2 domain	(Phosphotyrosine protein) phosphatases II	1	1
Dihydropteroate synthetase-like	Methionine synthase domain	1	1
P-loop containing nucleoside triphosphate hydrolases	GTPase activation domain, GAP	1	1
SMAD/FHA domain	RING/U-box	1	1
PH domain-like	Cullin repeat-like	1	1
PAH2 domain	Homeodomain-like	1	1
Tudor/PWWP/MBT	BRCT domain	1	1
EF-hand	Thyroglobulin type-1 domain	1	1
IP3 receptor type 1 binding core, domain 2	Concanavalin A-like lectins/glucanases	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
Metalloproteases ("zincins"), catalytic domain	Metalloproteases ("zincins"), catalytic domain	1	1
RuvA domain 2-like	WD40 repeat-like	1	1
ARM repeat	Mib/herc2 domain-like	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
SWIB/MDM2 domain	eIF1-like	1	1
Tex N-terminal region-like	Nucleic acid-binding proteins	1	1
P-loop containing nucleoside triphosphate hydrolases	Rad50 coiled-coil Zn hook	1	1
Leucine zipper domain	Leucine zipper domain	1	1
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	1	1
Calponin-homology domain, CH-domain	GTPase activation domain, GAP	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	1	1
Cysteine-rich DNA binding domain, (DM domain)	beta-sandwich domain of Sec23/24	1	1
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	1	1
SRCR-like	Pectin lyase-like	1	1
EF-hand	Immunoglobulin	1	1
Nucleic acid-binding proteins	GAD domain-like	1	1
C-type lectin-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
WWE domain	WGR domain-like	1	1
Actin depolymerizing proteins	SH3-domain	1	1
Tricorn protease domain 2	TPR-like	1	1
HSP20-like chaperones	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
F-box domain	P-loop containing nucleoside triphosphate hydrolases	1	1
L domain-like	DNase I-like	1	1
Somatomedin B domain	Family A G protein-coupled receptor-like	1	1
FYVE/PHD zinc finger	RNI-like	1	1
FYVE/PHD zinc finger	Rabenosyn-5 Rab-binding domain-like	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Voltage-gated potassium channels	1	1
Ubiquitin-like	FYVE/PHD zinc finger	1	1
NAD(P)-binding Rossmann-fold domains	Thioesterase/thiol ester dehydrase-isomerase	1	1
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	1	1
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	1	1
PH domain-like	HMG-box	1	1
Cadherin-like	ARM repeat	1	1
DEATH domain	RNI-like	1	1
P-loop containing nucleoside triphosphate hydrolases	FF domain	1	1
Doublecortin (DC)	beta-sandwich domain of Sec23/24	1	1
TrmE connector domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Actin-like ATPase domain	AF1104-like	1	1
Amidase signature (AS) enzymes	Amidase signature (AS) enzymes	1	1
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	1	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	1	1
PH domain-like	Glycolipid transfer protein, GLTP	1	1
p53-like transcription factors	p53 tetramerization domain	1	1
DNA-binding domain	RNI-like	1	1
FYVE/PHD zinc finger	Acyl-CoA N-acyltransferases (Nat)	1	1
mRNA decapping enzyme DcpS N-terminal domain	HIT-like	1	1
Histone-fold	FYVE/PHD zinc finger	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
NHL repeat	Quinoprotein alcohol dehydrogenase-like	1	1
SEA domain	LDL receptor-like module	1	1
Doublecortin (DC)	POZ domain	1	1
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	1	1
EF-hand	DUSP-like	1	1
L domain-like	PDZ domain-like	1	1
Calponin-homology domain, CH-domain	SH3-domain	1	1
Kazal-type serine protease inhibitors	Fibronectin type III	1	1
Quinoprotein alcohol dehydrogenase-like	Prefoldin	1	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
Cap-Gly domain	Cysteine proteinases	1	1
Oxysterol-binding protein-like	Oxysterol-binding protein-like	1	1
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	1	1
Spectrin repeat	DBL homology domain (DH-domain)	1	1
L9 N-domain-like	Ribonuclease H-like	1	1
Chaperone J-domain	RNA-binding domain, RBD	1	1
CalX-like	C-type lectin-like	1	1
Chromo domain-like	ClpP/crotonase	1	1
ARM repeat	Cystine-knot cytokines	1	1
Family A G protein-coupled receptor-like	SH3-domain	1	1
PheT/TilS domain	Putative DNA-binding domain	1	1
Leech antihemostatic proteins	Leech antihemostatic proteins	1	1
beta-sandwich domain of Sec23/24	WD40 repeat-like	1	1
Clavaminate synthase-like	RNI-like	1	1
Doublecortin (DC)	Pentapeptide repeat-like	1	1
Nucleotidylyl transferase	C-terminal domain of ProRS	1	1
CRAL/TRIO domain	(Phosphotyrosine protein) phosphatases II	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	NagB/RpiA/CoA transferase-like	1	1
HAD-like	BRCT domain	1	1
FAD-linked reductases, C-terminal domain	EF-hand	1	1
Eukaryotic type KH-domain (KH-domain type I)	RING/U-box	1	1