Domain combination pairs in Octopus bimaculoides 280

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

2020 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	1872	187
Cadherin-like	Cadherin-like	219	44
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	191	51
Ankyrin repeat	Ankyrin repeat	164	23
Ankyrin repeat	DEATH domain	150	11
EGF/Laminin	EGF/Laminin	143	95
Immunoglobulin	Immunoglobulin	124	48
RNA-binding domain, RBD	RNA-binding domain, RBD	78	19
ARM repeat	ARM repeat	68	27
FnI-like domain	FnI-like domain	62	43
Fibronectin type III	Fibronectin type III	61	32
Nicotinic receptor ligand binding domain-like	Neurotransmitter-gated ion-channel transmembrane pore	61	3
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	61	9
DBL homology domain (DH-domain)	PH domain-like	59	16
EGF/Laminin	Growth factor receptor domain	58	54
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	53	32
Actin-like ATPase domain	Actin-like ATPase domain	47	11
TPR-like	TPR-like	47	18
LDL receptor-like module	LDL receptor-like module	47	33
EGF/Laminin	Concanavalin A-like lectins/glucanases	44	29
Invertebrate chitin-binding proteins	Invertebrate chitin-binding proteins	42	20
Immunoglobulin	Fibronectin type III	42	21
TSP-1 type 1 repeat	TSP-1 type 1 repeat	41	32
Complement control module/SCR domain	Complement control module/SCR domain	37	28
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	37	13
Growth factor receptor domain	Growth factor receptor domain	35	32
Tubulin C-terminal domain-like	Tubulin nucleotide-binding domain-like	34	3
Thioredoxin-like	GST C-terminal domain-like	33	5
Homeodomain-like	Homeodomain-like	33	12
vWA-like	vWA-like	32	13
WD40 repeat-like	WD40 repeat-like	32	14
Spectrin repeat	Spectrin repeat	31	27
Cysteine-rich domain	PH domain-like	30	7
L domain-like	L domain-like	30	16
P-loop containing nucleoside triphosphate hydrolases	SMAD/FHA domain	30	8
E set domains	E set domains	29	18
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	28	9
(Trans)glycosidases	Chitinase insertion domain	27	5
Second domain of FERM	PH domain-like	27	17
RING/U-box	B-box zinc-binding domain	27	15
POZ domain	Kelch motif	26	5
EF-hand	EF-hand	26	12
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	26	18
P-loop containing nucleoside triphosphate hydrolases	PH domain-like	24	6
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	24	12
SH3-domain	PH domain-like	24	14
RING/U-box	RING/U-box	23	12
PDZ domain-like	PDZ domain-like	23	15
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	23	7
HAD-like	Calcium ATPase, transmembrane domain M	23	7
SH3-domain	SH3-domain	22	14
Protein kinase-like (PK-like)	ARM repeat	22	16
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	22	6
Ubiquitin-like	Second domain of FERM	22	16
SAM/Pointed domain	SAM/Pointed domain	22	6
Cysteine-rich domain	DBL homology domain (DH-domain)	22	2
Concanavalin A-like lectins/glucanases	LDL receptor-like module	22	15
Glucocorticoid receptor-like (DNA-binding domain)	Nuclear receptor ligand-binding domain	22	5
Ankyrin repeat	SOCS box-like	22	5
FYVE/PHD zinc finger	FYVE/PHD zinc finger	21	14
Hairpin loop containing domain-like	Hairpin loop containing domain-like	21	13
Cyclin-like	Cyclin-like	21	8
Calponin-homology domain, CH-domain	Glucocorticoid receptor-like (DNA-binding domain)	20	2
LDL receptor-like module	EGF/Laminin	20	13
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	20	8
Tropomyosin	Tropomyosin	20	1
Ubiquitin-like	PH domain-like	19	14
Voltage-gated potassium channels	Voltage-gated potassium channels	19	9
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	19	7
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	19	10
FAD/NAD(P)-binding domain	Glucocorticoid receptor-like (DNA-binding domain)	18	1
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	18	12
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	18	6
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	18	4
FAD/NAD(P)-binding domain	Calponin-homology domain, CH-domain	18	1
PH domain-like	PH domain-like	18	10
Sec7 domain	ARM repeat	17	2
MFS general substrate transporter	Kazal-type serine protease inhibitors	17	3
GroES-like	NAD(P)-binding Rossmann-fold domains	17	5
SMAD/FHA domain	PH domain-like	16	2
EGF/Laminin	vWA-like	16	14
Tudor/PWWP/MBT	Tudor/PWWP/MBT	16	12
Immunoglobulin	EGF/Laminin	16	10
FYVE/PHD zinc finger	Bromodomain	15	6
F-box domain	RNI-like	15	6
WW domain	WW domain	15	10
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	15	3
SRCR-like	SRCR-like	15	11
Calcium ATPase, transduction domain A	HAD-like	15	5
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	14	4
Spectrin repeat	EF-hand	14	13
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	14	8
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	14	6
Serine protease inhibitors	Serine protease inhibitors	14	8
P-loop containing nucleoside triphosphate hydrolases	SH3-domain	14	8
Kelch motif	Kelch motif	14	6
Quinoprotein alcohol dehydrogenase-like	WD40 repeat-like	14	10
RING/U-box	NHL repeat	13	4
(Trans)glycosidases	Glycosyl hydrolase domain	13	5
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	13	8
Ankyrin repeat	RING/U-box	13	7
TSP-1 type 1 repeat	Serine protease inhibitors	13	8
B-box zinc-binding domain	NHL repeat	13	5
cAMP-binding domain-like	cAMP-binding domain-like	13	8
Chromo domain-like	Chromo domain-like	13	5
BAR/IMD domain-like	SH3-domain	13	9
PH domain-like	(Phosphotyrosine protein) phosphatases II	13	7
ARM repeat	Formin homology 2 domain (FH2 domain)	13	5
L domain-like	Toll/Interleukin receptor TIR domain	13	8
FnI-like domain	PMP inhibitors	13	12
GroEL equatorial domain-like	GroEL apical domain-like	12	2
YWTD domain	EGF/Laminin	12	9
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	12	3
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	12	5
ABC transporter transmembrane region	ABC transporter transmembrane region	12	5
SH2 domain	Protein kinase-like (PK-like)	12	6
Thioredoxin-like	Thioredoxin-like	12	8
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	12	4
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex, superhelical domain	12	6
Ubiquitin-like	Ubiquitin-like	12	12
Concanavalin A-like lectins/glucanases	C-type lectin-like	12	1
Immunoglobulin	Concanavalin A-like lectins/glucanases	12	6
p53-like transcription factors	E set domains	12	5
Immunoglobulin	Protein kinase-like (PK-like)	12	7
Clc chloride channel	CBS-domain pair	12	4
RING/U-box	TRAF domain-like	12	9
LDL receptor-like module	Immunoglobulin	12	6
alpha-catenin/vinculin-like	alpha-catenin/vinculin-like	12	7
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	11	3
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	11	3
HMG-box	HMG-box	11	4
F-box domain	WD40 repeat-like	11	5
Cupredoxins	Cupredoxins	11	8
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	11	7
Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	11	5
MFS general substrate transporter	MFS general substrate transporter	11	4
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	11	1
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	11	5
POZ domain	Voltage-gated potassium channels	11	4
Growth factor receptor domain	Concanavalin A-like lectins/glucanases	11	8
Ubiquitin-like	Protein kinase-like (PK-like)	11	6
GroEL-intermediate domain like	GroEL apical domain-like	11	1
Protein kinase-like (PK-like)	Nucleotide cyclase	11	9
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	11	7
Spermadhesin, CUB domain	Spermadhesin, CUB domain	11	10
FYVE/PHD zinc finger	SET domain	11	4
LDL receptor-like module	Trypsin-like serine proteases	11	10
Fibronectin type III	Ankyrin repeat	11	1
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	11	3
PH domain-like	Ypt/Rab-GAP domain of gyp1p	11	3
GroEL equatorial domain-like	GroEL-intermediate domain like	11	1
BEACH domain	WD40 repeat-like	10	6
BRCT domain	BRCT domain	10	8
SH2 domain	SH3-domain	10	9
SH3-domain	DBL homology domain (DH-domain)	10	6
FYVE/PHD zinc finger	RING/U-box	10	4
WD40 repeat-like	ARM repeat	10	6
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	10	4
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	10	7
PreATP-grasp domain	Rudiment single hybrid motif	10	5
Nucleic acid-binding proteins	Nucleic acid-binding proteins	10	8
RING/U-box	E set domains	10	3
ENTH/VHS domain	GAT-like domain	10	2
Bromodomain	Bromodomain	10	4
Thiolase-like	Thiolase-like	10	3
PDZ domain-like	PH domain-like	10	6
RCC1/BLIP-II	Hect, E3 ligase catalytic domain	10	4
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	10	5
Cysteine-rich domain	Cysteine-rich domain	10	7
PH domain-like	GTPase activation domain, GAP	10	5
C2 domain (Calcium/lipid-binding domain, CaLB)	PDZ domain-like	10	2
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	10	1
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	10	4
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	9	5
HIT/MYND zinc finger-like	HIT/MYND zinc finger-like	9	9
ARM repeat	Clathrin adaptor appendage domain	9	3
Tudor/PWWP/MBT	ARID-like	9	2
P-loop containing nucleoside triphosphate hydrolases	Ankyrin repeat	9	7
PH domain-like	ArfGap/RecO-like zinc finger	9	3
EF-hand	GAS2 domain-like	9	8
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	9	6
Actin depolymerizing proteins	Actin depolymerizing proteins	9	6
vWA-like	Growth factor receptor domain	9	8
Spectrin repeat	GAS2 domain-like	9	8
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	9	5
Serine protease inhibitors	FnI-like domain	9	6
Invertebrate chitin-binding proteins	(Trans)glycosidases	9	4
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	9	2
Ubiquitin-like	UBA-like	9	4
RCC1/BLIP-II	Galactose-binding domain-like	8	2
FAS1 domain	FAS1 domain	8	4
Voltage-gated potassium channels	cAMP-binding domain-like	8	5
Cysteine-rich domain	Protein kinase-like (PK-like)	8	4
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	8	4
Metalloproteases ("zincins"), catalytic domain	TSP-1 type 1 repeat	8	8
Chitinase insertion domain	Invertebrate chitin-binding proteins	8	3
GAF domain-like	GAF domain-like	8	3
EGF/Laminin	Fibronectin type III	8	1
Regulator of G-protein signaling, RGS	DBL homology domain (DH-domain)	8	1
CalX-like	CalX-like	8	5
GAF domain-like	HD-domain/PDEase-like	8	4
Regulator of G-protein signaling, RGS	PH domain-like	8	1
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	8	4
Rudiment single hybrid motif	Single hybrid motif	8	4
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	8	5
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	8	3
Spermadhesin, CUB domain	EGF/Laminin	8	7
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	8	3
RCC1/BLIP-II	RCC1/BLIP-II	8	4
lambda repressor-like DNA-binding domains	Homeodomain-like	8	2
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	8	4
Regulator of G-protein signaling, RGS	Cysteine-rich domain	8	1
YWTD domain	LDL receptor-like module	8	7
PreATP-grasp domain	Single hybrid motif	8	4
C2 domain (Calcium/lipid-binding domain, CaLB)	PH domain-like	8	6
dsRNA-binding domain-like	dsRNA-binding domain-like	8	6
RCC1/BLIP-II	RING/U-box	8	2
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	8	4
Calponin-homology domain, CH-domain	E set domains	8	4
Ankyrin repeat	ArfGap/RecO-like zinc finger	8	5
EF-hand	RING/U-box	8	6
FYVE/PHD zinc finger	Tudor/PWWP/MBT	8	5
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	8	3
Galactose-binding domain-like	RING/U-box	8	2
EGF/Laminin	Complement control module/SCR domain	8	7
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	7	4
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	7	2
HMG-box	FYVE/PHD zinc finger	7	2
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	7	3
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	7	5
Cullin homology domain	"Winged helix" DNA-binding domain	7	4
Plakin repeat	Plakin repeat	7	6
DNA-binding protein LAG-1 (CSL)	E set domains	7	2
C2 domain (Calcium/lipid-binding domain, CaLB)	GTPase activation domain, GAP	7	4
RING/U-box	Cysteine proteinases	7	7
PDZ domain-like	SH3-domain	7	5
Ankyrin repeat	SH3-domain	7	4
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	7	5
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	7	4
Purple acid phosphatase, N-terminal domain	Metallo-dependent phosphatases	7	3
PMP inhibitors	PMP inhibitors	7	6
Protein kinase-like (PK-like)	P-loop containing nucleoside triphosphate hydrolases	7	3
Calponin-homology domain, CH-domain	Spectrin repeat	7	5
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	7	6
BAR/IMD domain-like	PH domain-like	7	4
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	7	5
YWTD domain	YWTD domain	7	7
Hairpin loop containing domain-like	Complement control module/SCR domain	7	7
Metalloproteases ("zincins"), catalytic domain	Concanavalin A-like lectins/glucanases	7	2
HMG-box	P-loop containing nucleoside triphosphate hydrolases	7	2
Spermadhesin, CUB domain	Complement control module/SCR domain	7	5
Voltage-gated potassium channels	Periplasmic binding protein-like II	7	6
ClpP/crotonase	ClpP/crotonase	7	3
Voltage-gated potassium channels	E set domains	7	2
p53-like transcription factors	DNA-binding protein LAG-1 (CSL)	7	2
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	7	5
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	7	1
Homeodomain-like	Glucocorticoid receptor-like (DNA-binding domain)	7	6
CoA-dependent acyltransferases	CoA-dependent acyltransferases	7	2
HIT/MYND zinc finger-like	TPR-like	7	4
FYVE/PHD zinc finger	Chromo domain-like	7	2
ARM repeat	Subdomain of clathrin and coatomer appendage domain	7	2
Concanavalin A-like lectins/glucanases	WD40 repeat-like	7	2
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	7	5
Ankyrin repeat	SAM/Pointed domain	7	7
Spermadhesin, CUB domain	LDL receptor-like module	7	7
HMG-box	Chromo domain-like	7	2
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	7	4
Fibronectin type III	Protein kinase-like (PK-like)	7	7
Intermediate filament protein, coiled coil region	Myosin rod fragments	7	6
Myosin rod fragments	Myosin rod fragments	7	4
PHM/PNGase F	PHM/PNGase F	7	4
Cysteine-rich domain	GTPase activation domain, GAP	6	4
WW domain	FF domain	6	2
Family A G protein-coupled receptor-like	Family A G protein-coupled receptor-like	6	6
SRCR-like	Trypsin-like serine proteases	6	6
RCC1/BLIP-II	E set domains	6	1
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	6	3
L domain-like	Immunoglobulin	6	4
Ankyrin repeat	ARM repeat	6	4
PH domain-like	I/LWEQ domain	6	1
RNI-like	EF-hand	6	2
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	6	3
Inosine monophosphate dehydrogenase (IMPDH)	Inosine monophosphate dehydrogenase (IMPDH)	6	2
SET domain	HIT/MYND zinc finger-like	6	3
Translation proteins	EF-G C-terminal domain-like	6	4
Rhodanese/Cell cycle control phosphatase	(Phosphotyrosine protein) phosphatases II	6	3
Second domain of FERM	I/LWEQ domain	6	1
Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	6	3
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	6	3
Cysteine proteinases	EF-hand	6	4
C2 domain (Calcium/lipid-binding domain, CaLB)	Ubiquitin-like	6	4
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	6	2
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	6	2
PH domain-like	WD40 repeat-like	6	3
PH domain-like	alpha-catenin/vinculin-like	6	1
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	6	4
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	6	4
RNA-binding domain, RBD	Ran binding protein zinc finger-like	6	2
Second domain of FERM	alpha-catenin/vinculin-like	6	1
PH domain-like	BEACH domain	6	3
PreATP-grasp domain	Methylglyoxal synthase-like	6	3
EF-hand	Cysteine-rich domain	6	2
Kringle-like	Protein kinase-like (PK-like)	6	2
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	6	2
DEATH domain	Caspase-like	6	2
Spectrin repeat	PH domain-like	6	3
Spectrin repeat	Plakin repeat	6	5
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	6	3
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	6	3
Second domain of FERM	A middle domain of Talin 1	6	1
Galactose-binding domain-like	Hect, E3 ligase catalytic domain	6	4
PDZ domain-like	P-loop containing nucleoside triphosphate hydrolases	6	4
Class I glutamine amidotransferase-like	PreATP-grasp domain	6	3
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	6	3
A middle domain of Talin 1	alpha-catenin/vinculin-like	6	1
Periplasmic binding protein-like I	Periplasmic binding protein-like II	6	5
Subtilisin-like	Galactose-binding domain-like	6	5
Ubiquitin-like	RING/U-box	6	4
TSP-1 type 1 repeat	FnI-like domain	6	3
E set domains	Galactose-binding domain-like	6	1
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	6	4
PP2C-like	Protein serine/threonine phosphatase 2C, C-terminal domain	6	1
EF-G C-terminal domain-like	EF-G C-terminal domain-like	6	4
Terpenoid cyclases/Protein prenyltransferases	Alpha-macroglobulin receptor domain	6	3
I/LWEQ domain	alpha-catenin/vinculin-like	6	1
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	6	2
WD40 repeat-like	TPR-like	6	4
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	6	2
Kringle-like	Kringle-like	6	2
Tudor/PWWP/MBT	HMG-box	6	1
Ankyrin repeat	Protein kinase-like (PK-like)	6	5
L domain-like	Family A G protein-coupled receptor-like	6	4
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	6	5
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	6	3
Class I glutamine amidotransferase-like	Carbamoyl phosphate synthetase, large subunit connection domain	6	3
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	6	4
PreATP-grasp domain	PreATP-grasp domain	6	3
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	6	2
A middle domain of Talin 1	I/LWEQ domain	6	1
Metalloproteases ("zincins"), catalytic domain	Hemopexin-like domain	6	5
SRCR-like	LDL receptor-like module	6	6
Class I glutamine amidotransferase-like	Glutathione synthetase ATP-binding domain-like	6	3
Intermediate filament protein, coiled coil region	Lamin A/C globular tail domain	6	4
Cullin repeat-like	Cullin homology domain	6	3
SH2 domain	PH domain-like	6	5
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	6	4
PX domain	Protein kinase-like (PK-like)	6	5
PH domain-like	Ankyrin repeat	6	3
HIT/MYND zinc finger-like	Tudor/PWWP/MBT	6	2
Concanavalin A-like lectins/glucanases	ARM repeat	6	2
SAM/Pointed domain	PH domain-like	6	3
FF domain	FF domain	6	2
L domain-like	Growth factor receptor domain	6	5
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	6	6
PH domain-like	Protein kinase-like (PK-like)	6	5
TSP-1 type 1 repeat	Immunoglobulin	6	6
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipoxigenase	6	1
EF-hand	PLC-like phosphodiesterases	6	5
PH domain-like	A middle domain of Talin 1	6	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	6	3
L domain-like	Protein kinase-like (PK-like)	5	4
ARM repeat	PH domain-like	5	2
Tudor/PWWP/MBT	SAM/Pointed domain	5	3
ARM repeat	Cysteine proteinases	5	3
ARM repeat	TPR-like	5	5
Glucocorticoid receptor-like (DNA-binding domain)	POZ domain	5	3
Zn-finger domain of Sec23/24	vWA-like	5	2
DEATH domain	DEATH domain	5	1
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	5	1
Nucleotidylyl transferase	S15/NS1 RNA-binding domain	5	3
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	5	2
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	5	3
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	5	2
BPTI-like	BPTI-like	5	4
ArfGap/RecO-like zinc finger	SH3-domain	5	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Methylglyoxal synthase-like	5	2
BAR/IMD domain-like	Ankyrin repeat	5	2
GST C-terminal domain-like	S15/NS1 RNA-binding domain	5	3
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	5	3
Periplasmic binding protein-like I	Voltage-gated potassium channels	5	4
C2 domain (Calcium/lipid-binding domain, CaLB)	vWA-like	5	3
Bromodomain	Tudor/PWWP/MBT	5	2
PH domain-like	Oxysterol-binding protein-like	5	3
TPR-like	SET domain	5	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Glutathione synthetase ATP-binding domain-like	5	2
Integrin domains	Integrin domains	5	4
Galactose-binding domain-like	Mib/herc2 domain-like	5	3
L27 domain	PDZ domain-like	5	3
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	5	2
Ran binding protein zinc finger-like	RING/U-box	5	3
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex; beta-sheet shell regions	5	3
Di-copper centre-containing domain	C-terminal domain of mollusc hemocyanin	5	5
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	5	2
Sema domain	Plexin repeat	5	5
Doublecortin (DC)	Doublecortin (DC)	5	4
L domain-like	P-loop containing nucleoside triphosphate hydrolases	5	4
WW domain	Hect, E3 ligase catalytic domain	5	5
Mib/herc2 domain-like	Hect, E3 ligase catalytic domain	5	3
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	5	2
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	5	3
Fibronectin type III	(Phosphotyrosine protein) phosphatases II	5	5
POZ domain	POZ domain	5	5
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	5	3
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	5	2
P-loop containing nucleoside triphosphate hydrolases	Concanavalin A-like lectins/glucanases	5	4
PDZ domain-like	DBL homology domain (DH-domain)	5	3
PurM N-terminal domain-like	PurM C-terminal domain-like	5	3
EGF/Laminin	Invertebrate chitin-binding proteins	5	5
SNARE-like	SNARE fusion complex	5	2
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	5	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Carbamoyl phosphate synthetase, large subunit connection domain	5	2
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	5	5
Homeodomain-like	RING/U-box	5	4
BRK domain-like	P-loop containing nucleoside triphosphate hydrolases	5	2
Cullin repeat-like	"Winged helix" DNA-binding domain	5	2
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	5	3
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	5	4
Periplasmic binding protein-like I	Protein kinase-like (PK-like)	5	5
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	5	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	PreATP-grasp domain	5	2
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	5	2
FKBP-like	TPR-like	5	3
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	5	2
Single hybrid motif	CoA-dependent acyltransferases	5	5
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	5	1
Ribonuclease H-like	DNA/RNA polymerases	5	5
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	5	3
GTPase activation domain, GAP	ARM repeat	5	1
PKD domain	PKD domain	5	5
vWA-like	Helical domain of Sec23/24	5	2
SAM/Pointed domain	"Winged helix" DNA-binding domain	5	4
RUN domain-like	SH3-domain	5	2
ARM repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	5	4
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	5	2
Integrin alpha N-terminal domain	Integrin domains	5	4
PGBD-like	Metalloproteases ("zincins"), catalytic domain	5	4
Plakin repeat	GAS2 domain-like	5	4
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	5	5
Intermediate filament protein, coiled coil region	Intermediate filament protein, coiled coil region	5	4
Metalloproteases ("zincins"), catalytic domain	Blood coagulation inhibitor (disintegrin)	5	2
EF-hand	Eferin C-derminal domain-like	5	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	5	2
ARM repeat	"Winged helix" DNA-binding domain	5	2
Second domain of FERM	Second domain of FERM	5	5
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	5	2
Calpain large subunit, middle domain (domain III)	EF-hand	5	3
GST C-terminal domain-like	Nucleotidylyl transferase	5	3
SH2 domain	SOCS box-like	5	2
Kazal-type serine protease inhibitors	Kazal-type serine protease inhibitors	5	4
Periplasmic binding protein-like I	Periplasmic binding protein-like I	5	4
NHL repeat	Soluble quinoprotein glucose dehydrogenase	5	2
SH3-domain	Protein kinase-like (PK-like)	5	5
Translation proteins	Ribosomal protein S5 domain 2-like	5	3
Plakin repeat	EF-hand	5	4
SAM/Pointed domain	GTPase activation domain, GAP	5	2
Flavoproteins	Riboflavin synthase domain-like	5	3
beta-sandwich domain of Sec23/24	Zn-finger domain of Sec23/24	5	2
beta-sandwich domain of Sec23/24	vWA-like	5	2
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	5	3
Glutathione synthetase ATP-binding domain-like	NAD(P)-binding Rossmann-fold domains	4	1
ARM repeat	BEACH domain	4	1
Myosin rod fragments	Lamin A/C globular tail domain	4	3
PreATP-grasp domain	ClpP/crotonase	4	1
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	4	4
Spermadhesin, CUB domain	Growth factor receptor domain	4	4
WW domain	EF-hand	4	3
Class I glutamine amidotransferase-like	Composite domain of metallo-dependent hydrolases	4	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	S15/NS1 RNA-binding domain	4	2
ArfGap/RecO-like zinc finger	GTPase activation domain, GAP	4	1
WD40 repeat-like	SNARE fusion complex	4	2
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	4	2
PABC (PABP) domain	Hect, E3 ligase catalytic domain	4	1
Metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	4	1
Concanavalin A-like lectins/glucanases	Trypsin-like serine proteases	4	4
NAD(P)-binding Rossmann-fold domains	ACP-like	4	2
B-box zinc-binding domain	E set domains	4	2
WW domain	RING/U-box	4	3
C-type lectin-like	C-type lectin-like	4	3
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	4	1
P-loop containing nucleoside triphosphate hydrolases	dsRNA-binding domain-like	4	2
PreATP-grasp domain	Metallo-dependent hydrolases	4	1
NAD(P)-binding Rossmann-fold domains	Citrate synthase	4	1
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	4	4
Galactose-binding domain-like	Galactose-binding domain-like	4	3
FYVE/PHD zinc finger	HIT/MYND zinc finger-like	4	1
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	4	1
Ribosomal L27 protein-like	Nucleic acid-binding proteins	4	2
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	4	1
Ypt/Rab-GAP domain of gyp1p	SH3-domain	4	1
PH domain-like	FYVE/PHD zinc finger	4	4
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	4	3
Glutathione synthetase ATP-binding domain-like	Metallo-dependent hydrolases	4	1
Acid proteases	DNA/RNA polymerases	4	2
USP8 N-terminal domain-like	JAB1/MPN domain	4	1
Ubiquitin-like	Ran binding protein zinc finger-like	4	2
Hairpin loop containing domain-like	C-type lectin-like	4	3
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	4	3
E set domains	P-loop containing nucleoside triphosphate hydrolases	4	2
RCC1/BLIP-II	PABC (PABP) domain	4	1
SH2 domain	SH2 domain	4	4
POZ domain	Galactose oxidase, central domain	4	3
PH domain-like	PLC-like phosphodiesterases	4	3
Methylglyoxal synthase-like	Composite domain of metallo-dependent hydrolases	4	1
Concanavalin A-like lectins/glucanases	BEACH domain	4	1
SEA domain	Frizzled cysteine-rich domain	4	2
Ypt/Rab-GAP domain of gyp1p	RUN domain-like	4	1
Glutathione synthetase ATP-binding domain-like	Citrate synthase	4	1
Single hybrid motif	ClpP/crotonase	4	1
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	4	3
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	4	3
Periplasmic binding protein-like I	Nucleotide cyclase	4	4
Thioredoxin-like	Ubiquitin-like	4	2
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	4	1
TPR-like	Protein kinase-like (PK-like)	4	4
ARM repeat	alpha/beta-Hydrolases	4	2
E set domains	Cysteine proteinases	4	3
Galactose mutarotase-like	(Trans)glycosidases	4	2
FLJ32549 domain-like	FLJ32549 C-terminal domain-like	4	1
Protein kinase-like (PK-like)	PDZ domain-like	4	1
Ras GEF	Cysteine-rich domain	4	1
PAZ domain	Ribonuclease H-like	4	3
Carbamoyl phosphate synthetase, large subunit connection domain	Composite domain of metallo-dependent hydrolases	4	1
Di-copper centre-containing domain	Di-copper centre-containing domain	4	4
Cysteine proteinases	Transglutaminase, two C-terminal domains	4	3
Rudiment single hybrid motif	ClpP/crotonase	4	1
Spectrin repeat	SH3-domain	4	4
TGS-like	ThrRS/AlaRS common domain	4	3
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	4	2
Sec63 N-terminal domain-like	E set domains	4	3
RING/U-box	Mib/herc2 domain-like	4	2
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	4	1
SAM/Pointed domain	ArfGap/RecO-like zinc finger	4	1
Succinyl-CoA synthetase domains	Citrate synthase	4	1
Carbamoyl phosphate synthetase, large subunit connection domain	Aspartate/ornithine carbamoyltransferase	4	1
RNA-binding domain, RBD	Clavaminate synthase-like	4	1
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	4	4
PreATP-grasp domain	Aspartate/ornithine carbamoyltransferase	4	1
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	4	1
Bromodomain	HIT/MYND zinc finger-like	4	1
HLH, helix-loop-helix DNA-binding domain	PYP-like sensor domain (PAS domain)	4	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Composite domain of metallo-dependent hydrolases	4	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Cysteine-rich domain	4	2
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	4	4
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	4	1
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	4	4
SET domain	beta-beta-alpha zinc fingers	4	3
Cysteine proteinases	Cysteine proteinases	4	4
Glutathione synthetase ATP-binding domain-like	Composite domain of metallo-dependent hydrolases	4	1
E set domains	Ankyrin repeat	4	2
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	4	2
P-loop containing nucleoside triphosphate hydrolases	PX domain	4	1
Methylglyoxal synthase-like	Aspartate/ornithine carbamoyltransferase	4	1
RNA-binding domain, RBD	Retrovirus zinc finger-like domains	4	2
RNA-binding domain, RBD	Tudor/PWWP/MBT	4	3
SET domain	Bromodomain	4	1
E set domains	NHL repeat	4	2
TAF(II)230 TBP-binding fragment	Bromodomain	4	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Metallo-dependent hydrolases	4	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	S15/NS1 RNA-binding domain	4	2
Concanavalin A-like lectins/glucanases	PH domain-like	4	1
Class I glutamine amidotransferase-like	Aspartate/ornithine carbamoyltransferase	4	1
GST C-terminal domain-like	Methionyl-tRNA synthetase (MetRS), Zn-domain	4	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	4	3
Glutathione synthetase ATP-binding domain-like	Aspartate/ornithine carbamoyltransferase	4	1
Carbamoyl phosphate synthetase, large subunit connection domain	Metallo-dependent hydrolases	4	1
C-terminal domain of mollusc hemocyanin	C-terminal domain of mollusc hemocyanin	4	4
Ankyrin repeat	alpha-catenin/vinculin-like	4	1
SAM/Pointed domain	PDZ domain-like	4	4
PH domain-like	EF-hand	4	3
Ankyrin repeat	L domain-like	4	3
POZ domain	beta-beta-alpha zinc fingers	4	4
PreATP-grasp domain	Composite domain of metallo-dependent hydrolases	4	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	4	2
Carboxypeptidase regulatory domain-like	Soluble quinoprotein glucose dehydrogenase	4	1
Retrovirus zinc finger-like domains	P-loop containing nucleoside triphosphate hydrolases	4	3
Hormone receptor domain	Family A G protein-coupled receptor-like	4	3
SMAD/FHA domain	C2 domain (Calcium/lipid-binding domain, CaLB)	4	1
Carboxypeptidase regulatory domain-like	NHL repeat	4	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Aspartate/ornithine carbamoyltransferase	4	1
E set domains	Transglutaminase, two C-terminal domains	4	3
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	4	4
SMAD/FHA domain	PX domain	4	1
HSP20-like chaperones	HSP20-like chaperones	4	2
Ankyrin repeat	Eukaryotic type KH-domain (KH-domain type I)	4	1
Class I glutamine amidotransferase-like	Metallo-dependent hydrolases	4	1
(Phosphotyrosine protein) phosphatases II	Cysteine-rich domain	4	2
P-loop containing nucleoside triphosphate hydrolases	C2 domain (Calcium/lipid-binding domain, CaLB)	4	1
Metalloproteases ("zincins"), catalytic domain	Spermadhesin, CUB domain	4	2
MAST3 pre-PK domain-like	PDZ domain-like	4	1
ARM repeat	P-loop containing nucleoside triphosphate hydrolases	4	2
BAR/IMD domain-like	GTPase activation domain, GAP	4	4
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	4	3
Phospholipase D/nuclease	Phospholipase D/nuclease	4	3
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	4	1
Ras GEF	PH domain-like	4	3
tRNA-binding arm	Class II aaRS and biotin synthetases	4	3
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	4	1
Ras GEF	Ubiquitin-like	4	3
MAST3 pre-PK domain-like	Protein kinase-like (PK-like)	4	1
P-loop containing nucleoside triphosphate hydrolases	TPR-like	4	4
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	4	3
EGF/Laminin	Integrin beta tail domain	4	3
SAM/Pointed domain	SH2 domain	4	3
Clavaminate synthase-like	S-adenosyl-L-methionine-dependent methyltransferases	4	1
Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	4	4
C-type lectin-like	LDL receptor-like module	4	4
Protein kinase-like (PK-like)	WD40 repeat-like	4	3
Sec7 domain	PH domain-like	4	3
Ras GEF	EF-hand	4	1
Composite domain of metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	4	1
BRK domain-like	Bromodomain	4	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	4	2
beta-beta-alpha zinc fingers	Homeodomain-like	4	4
GST C-terminal domain-like	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	4	2
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	4	1
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	4	2
Plexin repeat	E set domains	4	4
Methylglyoxal synthase-like	Metallo-dependent hydrolases	4	1
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	4	2
SAP domain	RNA-binding domain, RBD	3	2
ValRS/IleRS/LeuRS editing domain	tRNA-binding arm	3	1
EGF/Laminin	Family A G protein-coupled receptor-like	3	1
Toll/Interleukin receptor TIR domain	Toll/Interleukin receptor TIR domain	3	2
TSP-1 type 1 repeat	EGF/Laminin	3	3
Regulator of G-protein signaling, RGS	PX domain	3	1
Chaperone J-domain	Thioredoxin-like	3	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	3	3
Snake toxin-like	Protein kinase-like (PK-like)	3	3
L27 domain	SH3-domain	3	1
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	3	2
Plexin repeat	Integrin domains	3	2
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	3	1
MIR domain	IP3 receptor type 1 binding core, domain 2	3	3
Serine protease inhibitors	LDL receptor-like module	3	3
SAM/Pointed domain	RING/U-box	3	2
Ubiquitin-like	Acid proteases	3	1
(Trans)glycosidases	beta-Galactosidase/glucuronidase domain	3	3
Growth factor receptor domain	Protein kinase-like (PK-like)	3	3
Amine oxidase N-terminal region	Amine oxidase N-terminal region	3	1
L27 domain	P-loop containing nucleoside triphosphate hydrolases	3	1
Galactose-binding domain-like	(Trans)glycosidases	3	3
PsbU/PolX domain-like	Nucleotidyltransferase	3	2
PDZ domain-like	Ubiquitin-like	3	2
TGS-like	Class II aaRS and biotin synthetases	3	2
Concanavalin A-like lectins/glucanases	Family A G protein-coupled receptor-like	3	1
Complement control module/SCR domain	Growth factor receptor domain	3	3
Kringle-like	Immunoglobulin	3	1
(Trans)glycosidases	E set domains	3	2
L domain-like	Fibronectin type III	3	3
PABC (PABP) domain	PABC (PABP) domain	3	2
SH2 domain	RING/U-box	3	2
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	3	2
Plexin repeat	vWA-like	3	2
Second domain of FERM	SH3-domain	3	3
ATP-dependent DNA ligase DNA-binding domain	BRCT domain	3	3
Concanavalin A-like lectins/glucanases	Hect, E3 ligase catalytic domain	3	1
GTPase activation domain, GAP	SH3-domain	3	3
Cysteine-rich domain	SAM/Pointed domain	3	3
Protein kinase-like (PK-like)	Polo-box domain	3	2
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	3	1
TB module/8-cys domain	Growth factor receptor domain	3	3
Transglutaminase, two C-terminal domains	Transglutaminase, two C-terminal domains	3	2
RUN domain-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	3	1
Phosphofructokinase	Phosphofructokinase	3	1
TPR-like	HCP-like	3	3
CRAL/TRIO domain	Spectrin repeat	3	3
Growth factor receptor domain	Invertebrate chitin-binding proteins	3	3
ARM repeat	Toll/Interleukin receptor TIR domain	3	2
alpha/beta-Hydrolases	Lipase/lipooxygenase domain (PLAT/LH2 domain)	3	1
PX domain	SH3-domain	3	3
Histone-fold	ARM repeat	3	2
Transducin (heterotrimeric G protein), gamma chain	Regulator of G-protein signaling, RGS	3	2
CCCH zinc finger	CCCH zinc finger	3	2
ARM repeat	Chaperone J-domain	3	1
C-type lectin-like	Spermadhesin, CUB domain	3	3
RCC1/BLIP-II	Concanavalin A-like lectins/glucanases	3	1
WGR domain-like	ADP-ribosylation	3	3
FYVE/PHD zinc finger	Clavaminate synthase-like	3	3
UBA-like	UBA-like	3	2
Ubiquitin-like	ARM repeat	3	2
PX domain	BAR/IMD domain-like	3	3
Kazal-type serine protease inhibitors	Growth factor receptor domain	3	2
beta-N-acetylhexosaminidase-like domain	E set domains	3	2
RNI-like	L domain-like	3	3
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	tRNA-binding arm	3	1
LDL receptor-like module	Growth factor receptor domain	3	3
GINS helical bundle-like	PriA/YqbF domain	3	2
Cadherin-like	Concanavalin A-like lectins/glucanases	3	3
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	3	1
UBA-like	ARM repeat	3	2
RING/U-box	UBA-like	3	2
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	3	2
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	3	2
Nucleoside diphosphate kinase, NDK	Nucleoside diphosphate kinase, NDK	3	2
Myosin rod fragments	Tropomyosin	3	2
vWA-like	Integrin domains	3	2
Tudor/PWWP/MBT	P-loop containing nucleoside triphosphate hydrolases	3	3
RING/U-box	Calcium-dependent phosphotriesterase	3	3
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	3	2
beta-sandwich domain of Sec23/24	beta-beta-alpha zinc fingers	3	2
MIR domain	MIR domain	3	3
AN1-like Zinc finger	AN1-like Zinc finger	3	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	3	2
WGR domain-like	Domain of poly(ADP-ribose) polymerase	3	3
B-box zinc-binding domain	Calcium-dependent phosphotriesterase	3	3
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	3	2
RCC1/BLIP-II	WD40 repeat-like	3	1
Homeodomain-like	FAD/NAD(P)-binding domain	3	2
Nucleic acid-binding proteins	Translation proteins SH3-like domain	3	2
DUSP-like	Cysteine proteinases	3	3
Invertebrate chitin-binding proteins	Trypsin-like serine proteases	3	3
WD40 repeat-like	RING/U-box	3	3
ACT-like	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	3	2
P-loop containing nucleoside triphosphate hydrolases	RING/U-box	3	2
NAD(P)-binding Rossmann-fold domains	alpha/beta-Hydrolases	3	2
Invertebrate chitin-binding proteins	Concanavalin A-like lectins/glucanases	3	3
UBA-like	Cysteine proteinases	3	2
Carbohydrate-binding domain	(Trans)glycosidases	3	2
HLH, helix-loop-helix DNA-binding domain	Orange domain-like	3	1
Glutaminase/Asparaginase	Ankyrin repeat	3	2
WD40 repeat-like	Hect, E3 ligase catalytic domain	3	1
EGF/Laminin	TB module/8-cys domain	3	3
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	3	2
Hermes dimerisation domain	Ribonuclease H-like	3	2
Tryptophan synthase beta subunit-like PLP-dependent enzymes	CBS-domain pair	3	1
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	3	2
SAP domain	RING/U-box	3	1
Concanavalin A-like lectins/glucanases	Complement control module/SCR domain	3	3
"Winged helix" DNA-binding domain	SMAD/FHA domain	3	1
DEATH domain	RBP11-like subunits of RNA polymerase	3	1
C-type lectin-like	Immunoglobulin	3	3
GYF domain	Chaperone J-domain	3	1
TATA-box binding protein-like	DNA-glycosylase	3	1
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	3	2
RUN domain-like	RUN domain-like	3	1
Homeodomain-like	FAD-linked reductases, C-terminal domain	3	2
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	3	3
P-loop containing nucleoside triphosphate hydrolases	EF-hand	3	2
beta-beta-alpha zinc fingers	Formin homology 2 domain (FH2 domain)	3	3
Nucleotidylyl transferase	P-loop containing nucleoside triphosphate hydrolases	3	2
Carbon-nitrogen hydrolase	HIT-like	3	1
SNARE fusion complex	SNARE fusion complex	3	2
Cap-Gly domain	Ubiquitin-like	3	3
Heme-dependent peroxidases	TSP-1 type 1 repeat	3	2
Acid proteases	UBA-like	3	1
Carbohydrate-binding domain	beta-N-acetylhexosaminidase-like domain	3	2
Calponin-homology domain, CH-domain	Calponin-homology domain, CH-domain	3	2
SH3-domain	EF-hand	3	3
Ubiquitin-like	SH3-domain	3	3
Ubiquitin-like	Cysteine-rich domain	3	2
GTPase activation domain, GAP	SH2 domain	3	3
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	3	1
(Phosphotyrosine protein) phosphatases II	FYVE/PHD zinc finger	3	2
YWTD domain	Quinoprotein alcohol dehydrogenase-like	3	2
t-snare proteins	SNARE fusion complex	3	2
Flavoproteins	Radical SAM enzymes	3	1
DEATH domain	Protein kinase-like (PK-like)	3	1
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	3	2
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	3	2
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	P-loop containing nucleoside triphosphate hydrolases	3	1
Mib/herc2 domain-like	Ankyrin repeat	3	2
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	3	3
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	3	1
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	3	2
PGBD-like	Hemopexin-like domain	3	3
CAD & PB1 domains	Protein kinase-like (PK-like)	3	2
FKBP-like	EF-hand	3	1
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	3	1
SMAD/FHA domain	BRCT domain	3	2
PA domain	Zn-dependent exopeptidases	3	2
L domain-like	Outer arm dynein light chain 1	3	3
Amine oxidase N-terminal region	Amine oxidase catalytic domain	3	1
Nucleic acid-binding proteins	BRCT domain	3	3
Protein kinase-like (PK-like)	RCC1/BLIP-II	3	1
Nucleotidylyl transferase	tRNA-binding arm	3	1
Guanido kinase N-terminal domain	Glutamine synthetase/guanido kinase	3	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	3	2
UBC-like	RING/U-box	3	3
P-loop containing nucleoside triphosphate hydrolases	Ubiquitin-like	3	3
Integrin domains	EGF/Laminin	3	2
Homeodomain-like	POZ domain	3	3
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	3	2
Alkaline phosphatase-like	His-Me finger endonucleases	3	2
FnI-like domain	EGF/Laminin	3	3
Acetyl-CoA synthetase-like	ACP-like	3	2
RING/U-box	Tudor/PWWP/MBT	3	2
P-loop containing nucleoside triphosphate hydrolases	TGS-like	3	1
CAD & PB1 domains	RING/U-box	3	2
"Winged helix" DNA-binding domain	PH domain-like	3	2
Calponin-homology domain, CH-domain	EF-hand	3	3
TRAF domain-like	TRAF domain-like	3	3
Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	3	3
FYVE/PHD zinc finger	SAP domain	3	1
RuvA domain 2-like	RuvA domain 2-like	3	3
Calponin-homology domain, CH-domain	PH domain-like	3	1
RNase III domain-like	dsRNA-binding domain-like	3	2
Ran binding protein zinc finger-like	Cysteine proteinases	3	1
Ypt/Rab-GAP domain of gyp1p	Rhodanese/Cell cycle control phosphatase	3	2
Cap-Gly domain	Cap-Gly domain	3	3
P-loop containing nucleoside triphosphate hydrolases	PUA domain-like	3	2
EF-hand	Mitochondrial carrier	3	3
RNase III domain-like	RNase III domain-like	3	2
Ankyrin repeat	ADP-ribosylation	3	3
ARM repeat	GYF domain	3	1
YWTD domain	Growth factor receptor domain	3	3
Carbohydrate-binding domain	E set domains	3	2
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	3	2
Ankyrin repeat	Second domain of FERM	2	1
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	2	1
L domain-like	SAM/Pointed domain	2	1
Cytochrome b5-like heme/steroid binding domain	Galactose-binding domain-like	2	1
FabD/lysophospholipase-like	NAD(P)-binding Rossmann-fold domains	2	1
TSP-1 type 1 repeat	Trypsin-like serine proteases	2	1
Eukaryotic type KH-domain (KH-domain type I)	P-loop containing nucleoside triphosphate hydrolases	2	1
RUN domain-like	FYVE/PHD zinc finger	2	1
Polo-box domain	Polo-box domain	2	1
GroES-like	ACP-like	2	1
Nucleotidyltransferase	Retrovirus zinc finger-like domains	2	1
NAD kinase/diacylglycerol kinase-like	SAM/Pointed domain	2	2
E set domains	Terpenoid cyclases/Protein prenyltransferases	2	1
PurM N-terminal domain-like	Formyltransferase	2	1
Thyroglobulin type-1 domain	Thyroglobulin type-1 domain	2	2
WD40 repeat-like	FYVE/PHD zinc finger	2	2
EF-hand	PX domain	2	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	2	1
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, dispensable insert domain	2	1
ARM repeat	Hect, E3 ligase catalytic domain	2	2
Spectrin repeat	WW domain	2	2
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	2	2
UBC-like	Ribosomal protein S5 domain 2-like	2	1
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	2	2
Eukaryotic type KH-domain (KH-domain type I)	Retrovirus zinc finger-like domains	2	1
L domain-like	ADP-ribosylglycohydrolase	2	1
TSP type-3 repeat	TSP type-3 repeat	2	2
Cadherin-like	Dystroglycan, domain 2	2	2
CCHHC domain	CCHHC domain	2	1
Class II aaRS and biotin synthetases	Translation proteins	2	1
Tudor/PWWP/MBT	Hect, E3 ligase catalytic domain	2	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	VPS9 domain	2	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	2	1
Galactose-binding domain-like	TSP-1 type 1 repeat	2	1
Spermadhesin, CUB domain	Kelch motif	2	2
Tex N-terminal region-like	Ribonuclease H-like	2	2
POZ domain	TRAF domain-like	2	2
Calcium-dependent phosphotriesterase	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	2
Protein kinase-like (PK-like)	UBA-like	2	2
PurM C-terminal domain-like	Formyltransferase	2	1
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	2	2
VPS9 domain	Ankyrin repeat	2	1
Thiolase-like	GroES-like	2	1
Metallo-dependent phosphatases	EF-hand	2	1
TPR-like	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	2	2
FKBP-like	Myosin rod fragments	2	1
Mib/herc2 domain-like	Tudor/PWWP/MBT	2	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	GroES-like	2	1
EF-hand	NAD kinase/diacylglycerol kinase-like	2	1
Kazal-type serine protease inhibitors	Concanavalin A-like lectins/glucanases	2	1
ADC-like	Cdc48 domain 2-like	2	1
Aldolase	Single hybrid motif	2	1
vWA-like	Invertebrate chitin-binding proteins	2	2
"Winged helix" DNA-binding domain	E set domains	2	1
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	2	2
Rudiment single hybrid motif	Aldolase	2	1
Glutathione synthetase ATP-binding domain-like	PurM C-terminal domain-like	2	1
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	2	2
Quinoprotein alcohol dehydrogenase-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	2
Cytochrome b5-like heme/steroid binding domain	Mib/herc2 domain-like	2	1
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	2	2
Plexin repeat	GTPase activation domain, GAP	2	2
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	2	1
BPTI-like	Di-copper centre-containing domain	2	1
Rudiment single hybrid motif	PurM N-terminal domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	RNA-binding domain, RBD	2	2
Cation efflux protein transmembrane domain-like	Cation efflux protein transmembrane domain-like	2	1
Spectrin repeat	RING/U-box	2	2
vWA-like	Integrin beta tail domain	2	1
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	2	2
SH2 domain	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	2	2
P-loop containing nucleoside triphosphate hydrolases	PAZ domain	2	1
HMA, heavy metal-associated domain	HAD-like	2	2
PRTase-like	PRTase-like	2	2
His-Me finger endonucleases	HIT/MYND zinc finger-like	2	1
FYVE/PHD zinc finger	SAM/Pointed domain	2	1
PAP/OAS1 substrate-binding domain	PAP/OAS1 substrate-binding domain	2	1
Glucocorticoid receptor-like (DNA-binding domain)	SET domain	2	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	S-adenosyl-L-methionine-dependent methyltransferases	2	1
S-adenosyl-L-methionine-dependent methyltransferases	NAD(P)-binding Rossmann-fold domains	2	1
Glutathione synthetase ATP-binding domain-like	post-HMGL domain-like	2	1
Fibronectin type III	YWTD domain	2	2
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	2	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	NAD(P)-binding Rossmann-fold domains	2	1
BRCT domain	Domain of poly(ADP-ribose) polymerase	2	2
TB module/8-cys domain	TB module/8-cys domain	2	2
DNA breaking-rejoining enzymes	Eukaryotic DNA topoisomerase I, dispensable insert domain	2	1
TAZ domain	Nuclear receptor coactivator interlocking domain	2	2
DNase I-like	RNA-binding domain, RBD	2	1
Protein kinase-like (PK-like)	MIT domain	2	2
C2 domain (Calcium/lipid-binding domain, CaLB)	C-terminal domain of PLC-beta	2	2
DNase I-like	SAM/Pointed domain	2	1
LDL receptor-like module	Alpha-macroglobulin receptor domain	2	1
TPR-like	Chaperone J-domain	2	2
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	2	2
YVTN repeat-like/Quinoprotein amine dehydrogenase	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	2
Cytochrome b5-like heme/steroid binding domain	Hect, E3 ligase catalytic domain	2	1
PreATP-grasp domain	PurM N-terminal domain-like	2	1
Nucleotidylyl transferase	Ribosomal protein L25-like	2	2
E set domains	DEATH domain	2	1
Glutathione synthetase ATP-binding domain-like	Formyltransferase	2	1
Galactose-binding domain-like	(Phosphotyrosine protein) phosphatases II	2	2
CAD & PB1 domains	Cysteine-rich domain	2	1
Kazal-type serine protease inhibitors	EGF/Laminin	2	1
Zinc hairpin stack	RING/U-box	2	1
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	2	1
Rudiment single hybrid motif	Formyltransferase	2	1
RuvA domain 2-like	P-loop containing nucleoside triphosphate hydrolases	2	2
Carbamate kinase-like	ALDH-like	2	1
vWA-like	Complement control module/SCR domain	2	2
Acetyl-CoA synthetase-like	NAD(P)-binding Rossmann-fold domains	2	1
Ankyrin repeat	WD40 repeat-like	2	1
PH domain-like	FAT domain of focal adhesion kinase	2	2
Thiolase-like	ACP-like	2	1
LDL receptor-like module	Complement control module/SCR domain	2	2
Trypsin-like serine proteases	Trypsin-like serine proteases	2	2
Plexin repeat	Protein kinase-like (PK-like)	2	2
FYVE/PHD zinc finger	Supernatant protein factor (SPF), C-terminal domain	2	1
PDZ domain-like	Formin homology 2 domain (FH2 domain)	2	2
LDL receptor-like module	L domain-like	2	2
E set domains	AMPKBI-like	2	1
NHL repeat	WD40 repeat-like	2	2
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	1
Putative DNA-binding domain	SAND domain-like	2	1
PLC-like phosphodiesterases	C-terminal domain of PLC-beta	2	2
Tudor/PWWP/MBT	Staphylococcal nuclease	2	2
E set domains	GTPase activation domain, GAP	2	2
PAH2 domain	PAH2 domain	2	2
UBA-like	RNA-binding domain, RBD	2	1
NAD(P)-binding Rossmann-fold domains	SCP-like	2	2
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	2	1
C-type lectin-like	EGF/Laminin	2	2
RNA-binding domain, RBD	HIT/MYND zinc finger-like	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	1
PreATP-grasp domain	PurM C-terminal domain-like	2	1
Concanavalin A-like lectins/glucanases	EF-hand	2	1
Ubiquitin-like	FAT domain of focal adhesion kinase	2	2
Glycoside hydrolase/deacetylase	Glycoside hydrolase/deacetylase	2	1
CHY zinc finger-like	Zinc hairpin stack	2	1
Folate-binding domain	Aminomethyltransferase beta-barrel domain	2	2
Clathrin heavy-chain terminal domain	ARM repeat	2	1
Plexin repeat	EGF/Laminin	2	1
FabD/lysophospholipase-like	GroES-like	2	1
Alkaline phosphatase-like	Alkaline phosphatase-like	2	1
RING/U-box	TAZ domain	2	2
Rudiment single hybrid motif	post-HMGL domain-like	2	1
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	2	2
YWTD domain	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	2
PX domain	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
Annexin	Annexin	2	1
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	2
Glutathione synthetase ATP-binding domain-like	Aldolase	2	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	2	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	2	1
CAD & PB1 domains	UBA-like	2	1
Protein kinase-like (PK-like)	RNA-binding domain, RBD	2	1
Bromodomain	TAZ domain	2	2
RNA-binding domain, RBD	PABC (PABP) domain	2	1
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	2	2
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	2	2
SAM/Pointed domain	Toll/Interleukin receptor TIR domain	2	2
L domain-like	NTF2-like	2	1
Starch-binding domain-like	PLC-like phosphodiesterases	2	1
HR1 repeat	HR1 repeat	2	1
Nucleotidyltransferase	Nucleotidyltransferase	2	1
P-loop containing nucleoside triphosphate hydrolases	Myosin rod fragments	2	2
Ankyrin repeat	Hect, E3 ligase catalytic domain	2	2
HLH, helix-loop-helix DNA-binding domain	HMG-box	2	2
GTPase activation domain, GAP	VPS9 domain	2	1
LDL receptor-like module	Terpenoid cyclases/Protein prenyltransferases	2	1
C-type lectin-like	Complement control module/SCR domain	2	2
SET domain	WW domain	2	1
TGS-like	Class II aaRS ABD-related	2	1
Cysteine-rich domain	SH2 domain	2	2
cAMP-binding domain-like	Protein kinase-like (PK-like)	2	1
Serine protease inhibitors	Hairpin loop containing domain-like	2	2
Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	2	2
PurM C-terminal domain-like	PurM C-terminal domain-like	2	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	ACP-like	2	1
FabD/lysophospholipase-like	ACP-like	2	1
S-adenosyl-L-methionine-dependent methyltransferases	GroES-like	2	1
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	2	1
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
RNI-like	Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain	2	1
Rudiment single hybrid motif	PurM C-terminal domain-like	2	1
B-box zinc-binding domain	TRAF domain-like	2	1
Restriction endonuclease-like	RuvA domain 2-like	2	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	2	1
PreATP-grasp domain	Formyltransferase	2	1
Sema domain	E set domains	2	2
E set domains	Protein kinase-like (PK-like)	2	2
L domain-like	Snake toxin-like	2	2
S-adenosyl-L-methionine-dependent methyltransferases	ACP-like	2	1
HCP-like	HCP-like	2	2
Cysteine proteinases	beta-sandwich domain of Sec23/24	2	2
GroES-like	alpha/beta-Hydrolases	2	1
Thiolase-like	NAD(P)-binding Rossmann-fold domains	2	1
BRCT domain	WGR domain-like	2	2
Tudor/PWWP/MBT	6-phosphogluconate dehydrogenase C-terminal domain-like	2	1
HR1 repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
WD40 repeat-like	Ypt/Rab-GAP domain of gyp1p	2	2
RCC1/BLIP-II	Tudor/PWWP/MBT	2	1
Ubiquitin-like	Ankyrin repeat	2	2
Tudor/PWWP/MBT	Galactose-binding domain-like	2	1
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	2	2
PurM N-terminal domain-like	PurM N-terminal domain-like	2	1
MIT domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Zinc beta-ribbon	Cyclin-like	2	2
SET domain	RuBisCo LSMT C-terminal, substrate-binding domain	2	2
L domain-like	WD40 repeat-like	2	1
Tricorn protease domain 2	SOCS box-like	2	1
LDL receptor-like module	EF-hand	2	2
ARM repeat	Zn-dependent exopeptidases	2	1
WD40 repeat-like	Ribonuclease H-like	2	1
HR1 repeat	Protein kinase-like (PK-like)	2	1
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	2	2
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	2	1
Surp module (SWAP domain)	Surp module (SWAP domain)	2	2
Tudor/PWWP/MBT	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Initiation factor IF2/eIF5b, domain 3	Translation proteins	2	2
Translational machinery components	L30e-like	2	2
TPR-like	Clavaminate synthase-like	2	2
Cytochrome b5-like heme/steroid binding domain	RING/U-box	2	1
Translation proteins	ThrRS/AlaRS common domain	2	1
EF-hand	Mannose 6-phosphate receptor domain	2	2
RING/U-box	Nuclear receptor coactivator interlocking domain	2	2
PAZ domain	RNase III domain-like	2	1
Stathmin	Stathmin	2	1
Sema domain	Protein kinase-like (PK-like)	2	2
Avidin/streptavidin	Avidin/streptavidin	2	1
POZ domain	Ankyrin repeat	2	2
Voltage-gated potassium channels	Small-conductance potassium channel	2	1
PDZ domain-like	DEATH domain	2	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	2	1
S-adenosyl-L-methionine-dependent methyltransferases	alpha/beta-Hydrolases	2	1
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	2	2
Voltage-gated potassium channels	EF-hand	2	1
Cadherin-like	EGF/Laminin	2	2
LDL receptor-like module	Mannose 6-phosphate receptor domain	2	2
RNI-like	RNI-like	2	2
Pectin lyase-like	Pectin lyase-like	2	2
Hairpin loop containing domain-like	Trypsin-like serine proteases	2	2
Growth factor receptor domain	FnI-like domain	2	2
Taf5 N-terminal domain-like	WD40 repeat-like	2	1
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	2	2
E set domains	Alpha-macroglobulin receptor domain	2	1
PDZ domain-like	BAR/IMD domain-like	2	1
Quinoprotein alcohol dehydrogenase-like	TPR-like	2	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	2	1
Saposin	Saposin	2	2
Tex N-terminal region-like	RuvA domain 2-like	2	2
FnI-like domain	LDL receptor-like module	2	2
alpha-helical ferredoxin	FMN-linked oxidoreductases	2	2
CHY zinc finger-like	RING/U-box	2	1
GMP synthetase C-terminal dimerisation domain	GMP synthetase C-terminal dimerisation domain	2	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	2	1
ARM repeat	Rap/Ran-GAP	2	2
Ubiquitin-like	Cysteine proteinases	2	2
Family A G protein-coupled receptor-like	"Winged helix" DNA-binding domain	2	1
WD40 repeat-like	Cysteine proteinases	2	1
Cysteine proteinases	Galactose-binding domain-like	2	2
Ribonuclease H-like	RuvA domain 2-like	2	2
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	2	1
Glutathione synthetase ATP-binding domain-like	PurM N-terminal domain-like	2	1
Thiolase-like	FabD/lysophospholipase-like	2	1
p53-like transcription factors	DEATH domain	2	1
DBL homology domain (DH-domain)	BAR/IMD domain-like	2	2
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	2	2
NTF2-like	NTF2-like	2	1
Multidrug efflux transporter AcrB transmembrane domain	WD40 repeat-like	2	1
WW domain	PIN domain-like	2	1
Metalloproteases ("zincins"), catalytic domain	Complement control module/SCR domain	2	2
Metalloproteases ("zincins"), catalytic domain	EGF/Laminin	2	1
FabD/lysophospholipase-like	EF-hand	2	2
Tudor/PWWP/MBT	NAD(P)-binding Rossmann-fold domains	2	1
P-loop containing nucleoside triphosphate hydrolases	Second domain of FERM	2	2
ADC-like	P-loop containing nucleoside triphosphate hydrolases	2	1
A DNA-binding domain in eukaryotic transcription factors	Leucine zipper domain	2	2
HAD-like	HAD-like	2	2
Probable ACP-binding domain of malonyl-CoA ACP transacylase	alpha/beta-Hydrolases	2	1
HAD-like	FAD/NAD(P)-binding domain	2	2
FabD/lysophospholipase-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Thiolase-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	2	1
PK beta-barrel domain-like	PK C-terminal domain-like	2	1
Ankyrin repeat	Galactose-binding domain-like	2	2
DEATH domain	Toll/Interleukin receptor TIR domain	2	2
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	2	2
Galactose-binding domain-like	Growth factor receptor domain	2	2
L domain-like	EGF/Laminin	2	2
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	2	2
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipase/lipooxygenase domain (PLAT/LH2 domain)	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Smc hinge domain	2	1
Growth factor receptor domain	TSP-1 type 1 repeat	2	2
Pentapeptide repeat-like	Pentapeptide repeat-like	2	2
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	2	1
RING/U-box	Hect, E3 ligase catalytic domain	2	1
FYVE/PHD zinc finger	"Winged helix" DNA-binding domain	2	2
PUA domain-like	RING/U-box	2	2
Zn-dependent exopeptidases	Transferrin receptor-like dimerisation domain	2	2
p53-like transcription factors	Ankyrin repeat	2	1
L domain-like	RING/U-box	2	1
RING/U-box	Protein kinase-like (PK-like)	2	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	2	1
SH2 domain	DNase I-like	2	1
UBC-like	Endosomal sorting complex assembly domain	2	1
Granulin repeat	Granulin repeat	2	2
Pre-PUA domain	PUA domain-like	2	1
Second domain of FERM	Protein kinase-like (PK-like)	2	2
Cysteine proteinases	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
Cytochrome b5-like heme/steroid binding domain	Tudor/PWWP/MBT	2	1
Formyltransferase	FMT C-terminal domain-like	2	2
TPR-like	HSP20-like chaperones	2	2
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	2	2
Nucleotide-binding domain	FMN-linked oxidoreductases	2	2
EF-hand	WD40 repeat-like	2	2
SMAD MH1 domain	SMAD/FHA domain	2	1
PAP/OAS1 substrate-binding domain	Retrovirus zinc finger-like domains	2	1
MIT domain	MIT domain	2	2
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	2	1
beta-beta-alpha zinc fingers	WW domain	2	1
Eukaryotic type KH-domain (KH-domain type I)	Tudor/PWWP/MBT	2	2
PDZ domain-like	Second domain of FERM	2	1
Glucocorticoid receptor-like (DNA-binding domain)	FYVE/PHD zinc finger	2	1
EGF/Laminin	Heme-dependent peroxidases	2	1
Zn-dependent exopeptidases	Zn-dependent exopeptidases	2	2
L domain-like	Concanavalin A-like lectins/glucanases	2	2
PreATP-grasp domain	Aldolase	2	1
Calpain large subunit, middle domain (domain III)	C2 domain (Calcium/lipid-binding domain, CaLB)	2	1
Macro domain-like	Zn-dependent exopeptidases	2	1
RCC1/BLIP-II	Cytochrome b5-like heme/steroid binding domain	2	1
ARM repeat	WWE domain	2	2
P-loop containing nucleoside triphosphate hydrolases	RNase III domain-like	2	1
Immunoglobulin	Family A G protein-coupled receptor-like	2	1
RCC1/BLIP-II	Mib/herc2 domain-like	2	1
PDZ domain-like	(Phosphotyrosine protein) phosphatases II	2	2
RNA-binding domain, RBD	PWI domain	2	1
ACP-like	alpha/beta-Hydrolases	2	1
HLH, helix-loop-helix DNA-binding domain	Formin homology 2 domain (FH2 domain)	2	2
Metalloproteases ("zincins"), catalytic domain	Hairpin loop containing domain-like	2	2
TPR-like	"Winged helix" DNA-binding domain	2	2
post-HMGL domain-like	Single hybrid motif	2	1
Fibrinogen C-terminal domain-like	Growth factor receptor domain	2	1
Integrin domains	Integrin beta tail domain	2	1
PH domain-like	Moesin tail domain	2	1
Macro domain-like	RING/U-box	2	2
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	2	1
GST C-terminal domain-like	S-adenosyl-L-methionine-dependent methyltransferases	2	1
LDL receptor-like module	Hairpin loop containing domain-like	2	2
P-loop containing nucleoside triphosphate hydrolases	LigT-like	2	1
NAD(P)-binding Rossmann-fold domains	P-loop containing nucleoside triphosphate hydrolases	2	2
Single hybrid motif	Single hybrid motif	2	2
EF-hand	SH2 domain	2	2
Enolase N-terminal domain-like	Enolase C-terminal domain-like	2	2
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	2	2
Heat shock protein 70kD (HSP70), C-terminal subdomain	Heat shock protein 70kD (HSP70), C-terminal subdomain	2	1
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	2	1
"Winged helix" DNA-binding domain	dsRNA-binding domain-like	2	2
Protein kinase-like (PK-like)	FAT domain of focal adhesion kinase	2	2
PAZ domain	dsRNA-binding domain-like	2	1
ARM repeat	RING/U-box	2	2
PurM C-terminal domain-like	Class I glutamine amidotransferase-like	2	1
RCC1/BLIP-II	DBL homology domain (DH-domain)	2	1
Cysteine proteinases	Ribonuclease H-like	2	1
Methyl-accepting chemotaxis protein (MCP) signaling domain	Concanavalin A-like lectins/glucanases	2	2
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	2	1
SRCR-like	Concanavalin A-like lectins/glucanases	2	2
C2 domain (Calcium/lipid-binding domain, CaLB)	WW domain	2	2
C2 domain (Calcium/lipid-binding domain, CaLB)	DBL homology domain (DH-domain)	2	1
PreATP-grasp domain	post-HMGL domain-like	2	1
BRCT domain	Ankyrin repeat	2	2
Actin-crosslinking proteins	Actin-crosslinking proteins	2	2
Kelch motif	EGF/Laminin	2	2
Plexin repeat	Integrin beta tail domain	2	1
Spermadhesin, CUB domain	Concanavalin A-like lectins/glucanases	2	1
RUN domain-like	Supernatant protein factor (SPF), C-terminal domain	2	1
cAMP-binding domain-like	Ras GEF	2	2
SH3-domain	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
SAM/Pointed domain	ADP-ribosylation	2	2
DBL homology domain (DH-domain)	Ras GEF	2	2
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	1
Invertebrate chitin-binding proteins	Glycoside hydrolase/deacetylase	2	2
Periplasmic binding protein-like II	Periplasmic binding protein-like II	2	1
Thiolase-like	alpha/beta-Hydrolases	2	1
Aconitase iron-sulfur domain	LeuD/IlvD-like	2	1
EGF/Laminin	BPTI-like	2	1
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	2	1
ARM repeat	L domain-like	2	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	2	1
Actin depolymerizing proteins	VHP, Villin headpiece domain	2	2
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	2	1
TSP-1 type 1 repeat	Hairpin loop containing domain-like	2	2
Hairpin loop containing domain-like	SRCR-like	2	2
alpha-helical ferredoxin	Nucleotide-binding domain	2	2
BRCT domain	ADP-ribosylation	2	2
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	2	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	2	1
PP2C-like	PP2C-like	2	2
FabD/lysophospholipase-like	alpha/beta-Hydrolases	2	1
Second domain of FERM	FAT domain of focal adhesion kinase	2	2
P-loop containing nucleoside triphosphate hydrolases	DEATH domain	2	2
Aldolase	post-HMGL domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Quinoprotein alcohol dehydrogenase-like	2	2
cAMP-binding domain-like	Ubiquitin-like	2	2
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	2	2
Bromodomain	RING/U-box	2	2
EGF/Laminin	Di-copper centre-containing domain	2	1
PurM N-terminal domain-like	Class I glutamine amidotransferase-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	2	2
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	2	2
L domain-like	Actin depolymerizing proteins	2	1
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	2	1
L domain-like	Ubiquitin-like	2	2
EGF/Laminin	Methyl-accepting chemotaxis protein (MCP) signaling domain	2	2
S-adenosyl-L-methionine-dependent methyltransferases	Galactose oxidase, central domain	2	1
Growth factor receptor domain	NHL repeat	2	1
L domain-like	DEATH domain	2	2
Bromodomain	Nuclear receptor coactivator interlocking domain	2	2
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	2	1
Cap-Gly domain	L domain-like	2	2
ARM repeat	Mib/herc2 domain-like	1	1
GST C-terminal domain-like	C-terminal domain of ProRS	1	1
Cytochrome b5-like heme/steroid binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Sec63 N-terminal domain-like	Ribonuclease H-like	1	1
NAD(P)-binding Rossmann-fold domains	RING/U-box	1	1
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	cAMP-binding domain-like	1	1
Acyl-CoA binding protein	Ankyrin repeat	1	1
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	1	1
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	1	1
dsRNA-binding domain-like	Tudor/PWWP/MBT	1	1
P-loop containing nucleoside triphosphate hydrolases	FF domain	1	1
POZ domain	Pentapeptide repeat-like	1	1
Ankyrin repeat	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
SWIB/MDM2 domain	eIF1-like	1	1
Galactose-binding domain-like	Concanavalin A-like lectins/glucanases	1	1
NAD(P)-binding Rossmann-fold domains	Thioesterase/thiol ester dehydrase-isomerase	1	1
"Winged helix" DNA-binding domain	occludin/ELL-like	1	1
Ribosomal protein L25-like	S15/NS1 RNA-binding domain	1	1
Metalloproteases ("zincins"), catalytic domain	Metalloproteases ("zincins"), catalytic domain	1	1
MIT domain	Calpain large subunit, middle domain (domain III)	1	1
DNase I-like	Formin homology 2 domain (FH2 domain)	1	1
Tudor/PWWP/MBT	Chromo domain-like	1	1
RING/U-box	Fibronectin type III	1	1
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	1	1
TSP-1 type 1 repeat	PMP inhibitors	1	1
p53-like transcription factors	p53 tetramerization domain	1	1
P-loop containing nucleoside triphosphate hydrolases	R3H domain	1	1
Ribonuclease H-like	Nucleic acid-binding proteins	1	1
Macro domain-like	BRCT domain	1	1
ClpP/crotonase	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
Growth factor receptor domain	Ankyrin repeat	1	1
Periplasmic binding protein-like II	Protein kinase-like (PK-like)	1	1
TNF receptor-like	TNF receptor-like	1	1
ARM repeat	PX domain	1	1
Lipocalins	Lipocalins	1	1
Immunoglobulin	Caspase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Macro domain-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
Glycerol-3-phosphate (1)-acyltransferase	EF-hand	1	1
TPR-like	Metallo-dependent phosphatases	1	1
TPR-like	Toll/Interleukin receptor TIR domain	1	1
Cu,Zn superoxide dismutase-like	Cu,Zn superoxide dismutase-like	1	1
Kazal-type serine protease inhibitors	Protein kinase-like (PK-like)	1	1
Ankyrin repeat	beta-N-acetylhexosaminidase-like domain	1	1
PX domain	GTPase activation domain, GAP	1	1
ARM repeat	CYTH-like phosphatases	1	1
RNI-like	Trypsin-like serine proteases	1	1
Adenine nucleotide alpha hydrolases-like	YjgF-like	1	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	1	1
Galactose oxidase, central domain	Galactose oxidase, central domain	1	1
Nucleic acid-binding proteins	SH2 domain	1	1
MgtE membrane domain-like	MgtE membrane domain-like	1	1
HIT-like	HIT-like	1	1
EF-hand	Dimeric alpha+beta barrel	1	1
WD40 repeat-like	Nucleoporin domain	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain II	1	1
N-terminal domain of cbl (N-cbl)	RING/U-box	1	1
BAR/IMD domain-like	Protein kinase-like (PK-like)	1	1
DNase I-like	GTPase activation domain, GAP	1	1
Acid proteases	ARM repeat	1	1
RUN domain-like	PDZ domain-like	1	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
NHL repeat	Quinoprotein alcohol dehydrogenase-like	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	1	1
BRK domain-like	Elongation factor TFIIS domain 2	1	1
Hairpin loop containing domain-like	Concanavalin A-like lectins/glucanases	1	1
NAD(P)-binding Rossmann-fold domains	DHS-like NAD/FAD-binding domain	1	1
Sialidases	Sialidases	1	1
Heme-dependent peroxidases	Riboflavin synthase domain-like	1	1
R3H domain	RNA-binding domain, RBD	1	1
WD40 repeat-like	DPP6 N-terminal domain-like	1	1
Ubiquitin-like	PUA domain-like	1	1
Inhibitor of apoptosis (IAP) repeat	UBC-like	1	1
beta-sandwich domain of Sec23/24	SET domain	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	1	1
RING/U-box	DEATH domain	1	1
HAD-like	BRCT domain	1	1
PUG domain-like	Cysteine proteinases	1	1
WWE domain	Hect, E3 ligase catalytic domain	1	1
SMAD/FHA domain	PDZ domain-like	1	1
WW domain	FKBP-like	1	1
Soluble quinoprotein glucose dehydrogenase	RING/U-box	1	1
DEATH domain	RNI-like	1	1
ACP-like	ALDH-like	1	1
FYVE/PHD zinc finger	GroEL apical domain-like	1	1
Pseudouridine synthase	PUA domain-like	1	1
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	1	1
Chaperone J-domain	E set domains	1	1
EGF/Laminin	Notch domain	1	1
Surp module (SWAP domain)	Ubiquitin-like	1	1
N-terminal domain of cbl (N-cbl)	UBA-like	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	YWTD domain	1	1
Nucleic acid-binding proteins	Retrovirus zinc finger-like domains	1	1
Prokaryotic type I DNA topoisomerase	Zinc beta-ribbon	1	1
HAD-like	Protein kinase-like (PK-like)	1	1
Homocysteine S-methyltransferase	Dihydropteroate synthetase-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Putative DNA-binding domain	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
Rap/Ran-GAP	PDZ domain-like	1	1
SH3-domain	Fibronectin type III	1	1
dsRNA-binding domain-like	R3H domain	1	1
F-box domain	Kelch motif	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
N-terminal domain of cbl (N-cbl)	SH2 domain	1	1
RNI-like	ARM repeat	1	1
ARM repeat	EGF/Laminin	1	1
ARM repeat	HLH, helix-loop-helix DNA-binding domain	1	1
PH domain-like	HMG-box	1	1
Acetyl-CoA synthetase-like	Acetyl-CoA synthetase-like	1	1
NTF2-like	RNA-binding domain, RBD	1	1
WWE domain	ADP-ribosylation	1	1
Regulator of G-protein signaling, RGS	Ubiquitin-like	1	1
Kazal-type serine protease inhibitors	Immunoglobulin	1	1
Ubiquitin-like	(Phosphotyrosine protein) phosphatases II	1	1
TAFH domain-like	Histone-fold	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
TSP type-3 repeat	Concanavalin A-like lectins/glucanases	1	1
Ribosomal protein L25-like	Class II aaRS and biotin synthetases	1	1
BRCT domain	Nucleotidyltransferase	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
Tudor/PWWP/MBT	SET domain	1	1
Histone-fold	DBL homology domain (DH-domain)	1	1
THUMP domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
SAM/Pointed domain	E set domains	1	1
L domain-like	PDZ domain-like	1	1
HAD-like	P-loop containing nucleoside triphosphate hydrolases	1	1
EGF/Laminin	Trypsin-like serine proteases	1	1
Spectrin repeat	DBL homology domain (DH-domain)	1	1
ENTH/VHS domain	FYVE/PHD zinc finger	1	1
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	1	1
DNA-binding domain	RNI-like	1	1
TPR-like	Fic-like	1	1
Tudor/PWWP/MBT	CCHHC domain	1	1
DNA/RNA polymerases	L domain-like	1	1
YccV-like	ApaG-like	1	1
TROVE domain-like	vWA-like	1	1
Thioredoxin-like	ERP29 C domain-like	1	1
PKD domain	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
Protease propeptides/inhibitors	Zn-dependent exopeptidases	1	1
Chromo domain-like	BRK domain-like	1	1
SMAD/FHA domain	HAD-like	1	1
Immunoglobulin	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
CoA-dependent acyltransferases	Formin homology 2 domain (FH2 domain)	1	1
POZ domain	Skp1 dimerisation domain-like	1	1
Cobalamin (vitamin B12)-binding domain	Methionine synthase activation domain-like	1	1
BRCA2 helical domain	Nucleic acid-binding proteins	1	1
Ankyrin repeat	EF-hand	1	1
BRCT domain	PsbU/PolX domain-like	1	1
EPT/RTPC-like	EPT/RTPC-like	1	1
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	1	1
L domain-like	DNase I-like	1	1
vWA-like	Sensory domain-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
Cna protein B-type domain	Starch-binding domain-like	1	1
Class II aaRS ABD-related	C-terminal domain of ProRS	1	1
Thioredoxin-like	Galactose-binding domain-like	1	1
Protein kinase-like (PK-like)	KA1-like	1	1
Frizzled cysteine-rich domain	LDL receptor-like module	1	1
NAD(P)-binding Rossmann-fold domains	NagB/RpiA/CoA transferase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Microbial and mitochondrial ADK, insert "zinc finger" domain	1	1
EF-hand	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
vWA-like	TSP-1 type 1 repeat	1	1
Protein kinase-like (PK-like)	BEACH domain	1	1
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	1	1
CCCH zinc finger	RNA-binding domain, RBD	1	1
EGF/Laminin	TSP type-3 repeat	1	1
RNA-binding domain, RBD	SET domain	1	1
EF-hand	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
S15/NS1 RNA-binding domain	S15/NS1 RNA-binding domain	1	1
Alpha subunit of glutamate synthase, C-terminal domain	Nucleotide-binding domain	1	1
PHM/PNGase F	NHL repeat	1	1
POZ domain	WD40 repeat-like	1	1
p53-like transcription factors	SH2 domain	1	1
RING/U-box	SH3-domain	1	1
Invertebrate chitin-binding proteins	E set domains	1	1
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	1	1
Ankyrin repeat	TPR-like	1	1
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	1	1
DAK1/DegV-like	DhaL-like	1	1
AF1104-like	AF1104-like	1	1
Plexin repeat	Immunoglobulin	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	1	1
RuvA domain 2-like	F-box domain	1	1
Cap-Gly domain	Cysteine proteinases	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
S15/NS1 RNA-binding domain	C-terminal domain of ProRS	1	1
BRCT domain	post-AAA+ oligomerization domain-like	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Sialidases	1	1
HBS1-like domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Formyltransferase	ALDH-like	1	1
L9 N-domain-like	Ribonuclease H-like	1	1
Integrin alpha N-terminal domain	Integrin alpha N-terminal domain	1	1
Galactose-binding domain-like	EGF/Laminin	1	1
Serine protease inhibitors	Growth factor receptor domain	1	1
Thioredoxin-like	eEF1-gamma domain	1	1
Trypsin-like serine proteases	PDZ domain-like	1	1
RNA-binding domain, RBD	Class II aaRS ABD-related	1	1
Concanavalin A-like lectins/glucanases	RING/U-box	1	1
beta-beta-alpha zinc fingers	Phage fibre proteins	1	1
Regulator of G-protein signaling, RGS	Retrovirus zinc finger-like domains	1	1
Macro domain-like	CRAL/TRIO domain	1	1
RNA-binding domain, RBD	dsRNA-binding domain-like	1	1
Cyclophilin-like	RNA-binding domain, RBD	1	1
WD40 repeat-like	Cyclophilin-like	1	1
POZ domain	Galactose-binding domain-like	1	1
Retrovirus zinc finger-like domains	DNA/RNA polymerases	1	1
Ypt/Rab-GAP domain of gyp1p	EF-hand	1	1
GST C-terminal domain-like	Class II aaRS and biotin synthetases	1	1
Calponin-homology domain, CH-domain	RGC domain-like	1	1
(Trans)glycosidases	Six-hairpin glycosidases	1	1
Calponin-homology domain, CH-domain	Ubiquitin-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	RING/U-box	1	1
C-type lectin-like	Growth factor receptor domain	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HMG-box	1	1
Dom34/Pelota N-terminal domain-like	L30e-like	1	1
Rhodanese/Cell cycle control phosphatase	WW domain	1	1
F-box domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleic acid-binding proteins	GAD domain-like	1	1
TrmE connector domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Cysteine-rich DNA binding domain, (DM domain)	beta-sandwich domain of Sec23/24	1	1
PUA domain-like	SWIB/MDM2 domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Cysteine-rich domain	1	1
Homocysteine S-methyltransferase	Methionine synthase domain	1	1
Tricorn protease domain 2	WD40 repeat-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Rad50 coiled-coil Zn hook	1	1
Homeodomain-like	Creatinase/aminopeptidase	1	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	1	1
TSP-1 type 1 repeat	LDL receptor-like module	1	1
L domain-like	ADP-ribosylation	1	1
FAD-linked reductases, C-terminal domain	Folate-binding domain	1	1
Ankyrin repeat	Formin homology 2 domain (FH2 domain)	1	1
"Winged helix" DNA-binding domain	GTPase activation domain, GAP	1	1
SH3-domain	Phosphoglycerate mutase-like	1	1
Snake toxin-like	Family A G protein-coupled receptor-like	1	1
Ankyrin repeat	(Trans)glycosidases	1	1
Tricorn protease domain 2	RCC1/BLIP-II	1	1
RING/U-box	CCCH zinc finger	1	1
Bet v1-like	HAD-like	1	1
GFP-like	Growth factor receptor domain	1	1
Nucleotide-diphospho-sugar transferases	SAM/Pointed domain	1	1
DNA breaking-rejoining enzymes	POZ domain	1	1
EGF/Laminin	Ankyrin repeat	1	1
Fibronectin type III	Thioredoxin-like	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	E set domains	1	1
PheT/TilS domain	Putative DNA-binding domain	1	1
Calcium-dependent phosphotriesterase	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
Calpain large subunit, middle domain (domain III)	Calpain large subunit, middle domain (domain III)	1	1
PH domain-like	BSD domain-like	1	1
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Chaperone J-domain	1	1
BRCT domain	Homeodomain-like	1	1
Heme-dependent peroxidases	FnI-like domain	1	1
Class II aaRS and biotin synthetases	GAD domain-like	1	1
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain	WD40 repeat-like	1	1
B-box zinc-binding domain	P-loop containing nucleoside triphosphate hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	SMR domain-like	1	1
PH domain-like	C-terminal domain of PLC-beta	1	1
SH3-domain	WW domain	1	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	1	1
MOSC N-terminal domain-like	PK beta-barrel domain-like	1	1
SMI1/KNR4-like	ApaG-like	1	1
SAM/Pointed domain	Ras GEF	1	1
NHL repeat	Calcium-dependent phosphotriesterase	1	1
RING/U-box	beta-sandwich domain of Sec23/24	1	1
GTPase activation domain, GAP	RGC domain-like	1	1
FYVE/PHD zinc finger	EF-hand	1	1
Histone-fold	PH domain-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Nucleic acid-binding proteins	1	1
SAM/Pointed domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Thioredoxin-like	"Winged helix" DNA-binding domain	1	1
DBL homology domain (DH-domain)	SH2 domain	1	1
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	1	1
Protein kinase-like (PK-like)	Rhodanese/Cell cycle control phosphatase	1	1
PUG domain-like	Ubiquitin-like	1	1
Ubiquitin-like	FYVE/PHD zinc finger	1	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	1	1
DNase I-like	MFS general substrate transporter	1	1
SIS domain	SIS domain	1	1
ALDH-like	ALDH-like	1	1
RING/U-box	DUSP-like	1	1
Cytochrome b5-like heme/steroid binding domain	HSP20-like chaperones	1	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	1	1
Tudor/PWWP/MBT	HIV integrase-binding domain	1	1
A heparin-binding domain	CAPPD, an extracellular domain of amyloid beta A4 protein	1	1
PR-1-like	PR-1-like	1	1
GST C-terminal domain-like	Class II aaRS ABD-related	1	1
SMAD/FHA domain	Protein kinase-like (PK-like)	1	1
Chaperone J-domain	Sec63 N-terminal domain-like	1	1
YaeB-like	YaeB-like	1	1
Notch domain	Ankyrin repeat	1	1
Doublecortin (DC)	Pentapeptide repeat-like	1	1
Ribosomal protein L25-like	C-terminal domain of ProRS	1	1
vWA-like	SPOC domain-like	1	1
Methylglyoxal synthase-like	Cytidine deaminase-like	1	1
FAD-linked reductases, C-terminal domain	Aminomethyltransferase beta-barrel domain	1	1
TATA-box binding protein-like	TATA-box binding protein-like	1	1
P-loop containing nucleoside triphosphate hydrolases	SOCS box-like	1	1
FnI-like domain	Leech antihemostatic proteins	1	1
HBS1-like domain	Translation proteins	1	1
PLP-dependent transferases	Adenine nucleotide alpha hydrolases-like	1	1
ArfGap/RecO-like zinc finger	Family A G protein-coupled receptor-like	1	1
Second domain of FERM	(Phosphotyrosine protein) phosphatases II	1	1
Immunoglobulin	Trypsin-like serine proteases	1	1
ARM repeat	CalX-like	1	1
Ribonuclease H-like	RNA-binding domain, RBD	1	1
Quinoprotein alcohol dehydrogenase-like	UBC-like	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
Galactose-binding domain-like	BRCT domain	1	1
RuvA domain 2-like	Nucleic acid-binding proteins	1	1
Nucleic acid-binding proteins	TPR-like	1	1
Nucleotidylyl transferase	Class II aaRS and biotin synthetases	1	1
RNA-binding domain, RBD	Eukaryotic type KH-domain (KH-domain type I)	1	1
Invertebrate chitin-binding proteins	beta-N-acetylhexosaminidase-like domain	1	1
Galactose-binding domain-like	Protein kinase-like (PK-like)	1	1
Calponin-homology domain, CH-domain	GTPase activation domain, GAP	1	1
TPR-like	RING/U-box	1	1
Clavaminate synthase-like	RNI-like	1	1
Aminoacid dehydrogenase-like, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Tex N-terminal region-like	SH2 domain	1	1
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	1	1
C-type lectin-like	Fibronectin type III	1	1
Quinoprotein alcohol dehydrogenase-like	EF-hand	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
ARM repeat	HSP20-like chaperones	1	1
PA domain	Transferrin receptor-like dimerisation domain	1	1
Ubiquitin-like	XPC-binding domain	1	1
alpha/beta knot	Nucleic acid-binding proteins	1	1
cAMP-binding domain-like	PDZ domain-like	1	1
Ankyrin repeat	RNI-like	1	1
Formin homology 2 domain (FH2 domain)	RING/U-box	1	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	1	1
GAT-like domain	Clathrin adaptor appendage domain	1	1
Plexin repeat	TSP-1 type 1 repeat	1	1
Ligand-binding domain in the NO signalling and Golgi transport	Nucleotide cyclase	1	1
UBA-like	WWE domain	1	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	1	1
SH2 domain	UBA-like	1	1
Immunoglobulin	FnI-like domain	1	1
cAMP-binding domain-like	FabD/lysophospholipase-like	1	1
FMT C-terminal domain-like	ACP-like	1	1
BEACH domain	FYVE/PHD zinc finger	1	1
EF-hand	Thyroglobulin type-1 domain	1	1
Kazal-type serine protease inhibitors	L domain-like	1	1
CRAL/TRIO domain	(Phosphotyrosine protein) phosphatases II	1	1
Ribonuclease H-like	HRDC-like	1	1
PX domain	TPR-like	1	1
DNA-binding domain	FYVE/PHD zinc finger	1	1
F-box domain	ApaG-like	1	1
PH domain-like	Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	1	1
GST C-terminal domain-like	Ribosomal protein L25-like	1	1
TSP-1 type 1 repeat	Concanavalin A-like lectins/glucanases	1	1
"Winged helix" DNA-binding domain	GroEL apical domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	DPP6 N-terminal domain-like	1	1
GroES-like	GroES-like	1	1
"Winged helix" DNA-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Dihydropteroate synthetase-like	Cobalamin (vitamin B12)-binding domain	1	1
PX domain	L domain-like	1	1
Heme-dependent peroxidases	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
BRCT domain	DNA/RNA polymerases	1	1
HSP20-like chaperones	Riboflavin synthase domain-like	1	1
Histone-fold	FYVE/PHD zinc finger	1	1
DNA clamp	DNA clamp	1	1
Glucocorticoid receptor-like (DNA-binding domain)	beta-beta-alpha zinc fingers	1	1
Galactose mutarotase-like	Glycosyl hydrolase domain	1	1
F-box domain	Cyclin-like	1	1
Homeodomain-like	L-aspartase-like	1	1
AXH domain	HMG-box	1	1
FYVE/PHD zinc finger	Elongation factor TFIIS domain 2	1	1
Tex N-terminal region-like	Nucleic acid-binding proteins	1	1
ENTH/VHS domain	SH3-domain	1	1
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	Formin homology 2 domain (FH2 domain)	1	1
Cysteine proteinases	Tudor/PWWP/MBT	1	1
PLC-like phosphodiesterases	PLC-like phosphodiesterases	1	1
Ribonuclease H-like	SH2 domain	1	1
FAD-linked reductases, C-terminal domain	EF-hand	1	1
Acyl-CoA binding protein	Supernatant protein factor (SPF), C-terminal domain	1	1
Acyl-CoA binding protein	ClpP/crotonase	1	1
Kelch motif	Galactose oxidase, central domain	1	1
Formyltransferase	ACP-like	1	1
Arp2/3 complex subunits	Arp2/3 complex subunits	1	1
PX domain	MIT domain	1	1
Concanavalin A-like lectins/glucanases	Protein kinase-like (PK-like)	1	1
Histone-fold	Macro domain-like	1	1
FAD/NAD(P)-binding domain	Aminomethyltransferase beta-barrel domain	1	1
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	1	1
(Phosphotyrosine protein) phosphatases II	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
Formate/glycerate dehydrogenase catalytic domain-like	DHS-like NAD/FAD-binding domain	1	1
BRCT domain	DNA polymerase beta, N-terminal domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
SH3-domain	Plakin repeat	1	1
SRCR-like	Pectin lyase-like	1	1
SH3-domain	UBA-like	1	1
Amyloid beta a4 protein copper binding domain (domain 2)	CAPPD, an extracellular domain of amyloid beta A4 protein	1	1
PH domain-like	RING/U-box	1	1
Concanavalin A-like lectins/glucanases	FnI-like domain	1	1
RING/U-box	RNA-binding domain, RBD	1	1
Doublecortin (DC)	POZ domain	1	1
DNA/RNA polymerases	Zinc finger domain of DNA polymerase-alpha	1	1
WD40 repeat-like	Prefoldin	1	1
HSP20-like chaperones	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Growth factor receptor domain	Fibronectin type III	1	1
PUA domain-like	Nucleotidylyl transferase	1	1
Ankyrin repeat	YWTD domain	1	1
RNA-binding domain, RBD	beta-sandwich domain of Sec23/24	1	1
Doublecortin (DC)	Protein kinase-like (PK-like)	1	1
P-loop containing nucleoside triphosphate hydrolases	Ribonuclease H-like	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	1	1
EF-hand	UBA-like	1	1
Ankyrin repeat	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Ribosomal protein L25-like	Class II aaRS ABD-related	1	1
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	1	1
Ubiquitin-like	Zn-binding ribosomal proteins	1	1
Nucleic acid-binding proteins	BRCA2 tower domain	1	1
Carboxypeptidase regulatory domain-like	Carboxypeptidase regulatory domain-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	beta-sandwich domain of Sec23/24	1	1
PLC-like phosphodiesterases	Ubiquitin-like	1	1
Protein kinase-like (PK-like)	Ypt/Rab-GAP domain of gyp1p	1	1
Methionine synthase domain	Cobalamin (vitamin B12)-binding domain	1	1
E set domains	Hect, E3 ligase catalytic domain	1	1
"Winged helix" DNA-binding domain	beta-sandwich domain of Sec23/24	1	1
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	1	1
CAD & PB1 domains	His-Me finger endonucleases	1	1
ARID-like	Chromo domain-like	1	1
Lipovitellin-phosvitin complex, superhelical domain	vWA-like	1	1
Sema domain	Immunoglobulin	1	1
Translation proteins	Translation proteins	1	1
Eukaryotic type KH-domain (KH-domain type I)	SAM/Pointed domain	1	1
Concanavalin A-like lectins/glucanases	SOCS box-like	1	1
Insect cysteine-rich antifreeze protein	Insect cysteine-rich antifreeze protein	1	1
HMA, heavy metal-associated domain	Cu,Zn superoxide dismutase-like	1	1
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	Pyrimidine nucleoside phosphorylase C-terminal domain	1	1
GST C-terminal domain-like	eEF-1beta-like	1	1
Band 7/SPFH domain	SCP-like	1	1
SAP domain	Concanavalin A-like lectins/glucanases	1	1
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	1	1
DBL homology domain (DH-domain)	FYVE/PHD zinc finger	1	1
ENTH/VHS domain	Clathrin adaptor appendage domain	1	1
ADP-ribosylation	ADP-ribosylation	1	1
FMT C-terminal domain-like	ALDH-like	1	1
Family A G protein-coupled receptor-like	SH3-domain	1	1
F-box domain	Sec7 domain	1	1
FAD/NAD(P)-binding domain	EF-hand	1	1
Thioredoxin-like	FAD/NAD(P)-binding domain	1	1
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Methenyltetrahydrofolate cyclohydrolase-like	1	1
PLP-dependent transferases	PLP-dependent transferases	1	1
BAR/IMD domain-like	SH2 domain	1	1
NAD kinase/diacylglycerol kinase-like	NAD kinase/diacylglycerol kinase-like	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
FYVE/PHD zinc finger	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Ankyrin repeat	Domain of poly(ADP-ribose) polymerase	1	1
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	1	1
Ankyrin repeat	Cap-Gly domain	1	1
SAICAR synthase-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
TPR-like	RNA-binding domain, RBD	1	1
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	1	1
EPT/RTPC-like	RNA 3'-terminal phosphate cyclase, RPTC, insert domain	1	1
WW domain	PH domain-like	1	1
Chromo domain-like	ClpP/crotonase	1	1
Leucine zipper domain	Leucine zipper domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	1	1
Thiolase-like	SCP-like	1	1
Apolipoprotein A-I	Apolipoprotein A-I	1	1
ADP-ribosylation	Outer arm dynein light chain 1	1	1
TSP-1 type 1 repeat	GFP-like	1	1
FAS1 domain	Growth factor receptor domain	1	1
Carbonic anhydrase	Carbonic anhydrase	1	1
EF-hand	C-terminal domain of PLC-beta	1	1
P-loop containing nucleoside triphosphate hydrolases	AN1-like Zinc finger	1	1
PEBP-like	PEBP-like	1	1
BAR/IMD domain-like	Family A G protein-coupled receptor-like	1	1
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	1	1
Dihydropteroate synthetase-like	Methionine synthase activation domain-like	1	1
Regulator of G-protein signaling, RGS	Protein kinase-like (PK-like)	1	1
Oxysterol-binding protein-like	Oxysterol-binding protein-like	1	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	1	1
Concanavalin A-like lectins/glucanases	Fibrinogen C-terminal domain-like	1	1
(Phosphotyrosine protein) phosphatases II	Nucleic acid-binding proteins	1	1
Kazal-type serine protease inhibitors	TSP-1 type 1 repeat	1	1
Calponin-homology domain, CH-domain	GAS2 domain-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	VPS9 domain	1	1
beta-beta-alpha zinc fingers	ARM repeat	1	1
A heparin-binding domain	Amyloid beta a4 protein copper binding domain (domain 2)	1	1
Protein kinase-like (PK-like)	HCP-like	1	1
Tricorn protease domain 2	TPR-like	1	1
Cytochrome b5-like heme/steroid binding domain	Riboflavin synthase domain-like	1	1
(Trans)glycosidases	(Trans)glycosidases	1	1
Actin depolymerizing proteins	SH3-domain	1	1
PUA domain-like	eIF1-like	1	1
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	1	1
F-box domain	UBC-like	1	1
MIR domain	Concanavalin A-like lectins/glucanases	1	1
Kringle-like	Concanavalin A-like lectins/glucanases	1	1
F-box domain	YccV-like	1	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	1	1
Hedgehog/DD-peptidase	Hedgehog/DD-peptidase	1	1
Cystine-knot cytokines	Cystine-knot cytokines	1	1
SH2 domain	(Phosphotyrosine protein) phosphatases II	1	1
beta-sandwich domain of Sec23/24	Protein kinase-like (PK-like)	1	1
PH domain-like	Phospholipase D/nuclease	1	1
Doublecortin (DC)	beta-sandwich domain of Sec23/24	1	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
ARM repeat	Galactose-binding domain-like	1	1
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	1	1
Second domain of FERM	RING/U-box	1	1
RUN domain-like	PH domain-like	1	1
vWA-like	Cysteine-rich domain	1	1
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	1	1
BRCT domain	DBL homology domain (DH-domain)	1	1
beta-beta-alpha zinc fingers	Leucine zipper domain	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
F-box domain	Concanavalin A-like lectins/glucanases	1	1
Ankyrin repeat	FabD/lysophospholipase-like	1	1
(Trans)glycosidases	Beta-D-glucan exohydrolase, C-terminal domain	1	1
GST C-terminal domain-like	eEF1-gamma domain	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Hect, E3 ligase catalytic domain	1	1
Ribonuclease H-like	Ribonuclease H-like	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	LDL receptor-like module	1	1
Chaperone J-domain	RNA-binding domain, RBD	1	1
lambda repressor-like DNA-binding domains	lambda repressor-like DNA-binding domains	1	1
YVTN repeat-like/Quinoprotein amine dehydrogenase	NHL repeat	1	1
Soluble quinoprotein glucose dehydrogenase	SAM/Pointed domain	1	1
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	1	1
Histone-fold	Histone-fold	1	1
ISP transmembrane anchor	ISP domain	1	1
SRCR-like	C-type lectin-like	1	1
RING/U-box	WWE domain	1	1
FAD/NAD(P)-binding domain	Folate-binding domain	1	1
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
FKBP-like	FKBP-like	1	1
WW domain	Cysteine proteinases	1	1
LDL receptor-like module	Fibronectin type III	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	1	1
Nucleotidylyl transferase	Nucleotidylyl transferase	1	1
Subtilisin-like	Growth factor receptor domain	1	1
Cadherin-like	ARM repeat	1	1
YWTD domain	Complement control module/SCR domain	1	1
RuvA domain 2-like	SH2 domain	1	1
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	1	1
Leukotriene A4 hydrolase N-terminal domain	Leukotriene A4 hydrolase N-terminal domain	1	1
DNA/RNA polymerases	ARM repeat	1	1
UBA-like	DNase I-like	1	1
Quinoprotein alcohol dehydrogenase-like	DPP6 N-terminal domain-like	1	1
Family A G protein-coupled receptor-like	DEATH domain	1	1
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain III	1	1
Macro domain-like	ADP-ribosylation	1	1
Oxidoreductase molybdopterin-binding domain	E set domains	1	1
Notch domain	Notch domain	1	1
Hypothetical protein c14orf129, hspc210	TPR-like	1	1
Homeodomain-like	JAB1/MPN domain	1	1
Cytochrome b5-like heme/steroid binding domain	Oxidoreductase molybdopterin-binding domain	1	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	1	1
Kringle-like	(Phosphotyrosine protein) phosphatases II	1	1
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain I	1	1
Protease propeptides/inhibitors	Subtilisin-like	1	1
TPR-like	PUA domain-like	1	1
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
Sec63 N-terminal domain-like	DNA/RNA polymerases	1	1
PDZ domain-like	"Winged helix" DNA-binding domain	1	1
CCHHC domain	Acyl-CoA N-acyltransferases (Nat)	1	1
IP3 receptor type 1 binding core, domain 2	IP3 receptor type 1 binding core, domain 2	1	1
SAM/Pointed domain	Hect, E3 ligase catalytic domain	1	1
Ankyrin repeat	HIT/MYND zinc finger-like	1	1
DNA-binding domain	SET domain	1	1
E set domains	Pectin lyase-like	1	1
SH2 domain	PLC-like phosphodiesterases	1	1
Spectrin repeat	Immunoglobulin	1	1
Ankyrin repeat	PDZ domain-like	1	1
DBL homology domain (DH-domain)	Quinoprotein alcohol dehydrogenase-like	1	1
Serine protease inhibitors	vWA-like	1	1
BSD domain-like	BSD domain-like	1	1
Doublecortin (DC)	Ricin B-like lectins	1	1
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	1	1
Cytochrome b5-like heme/steroid binding domain	E set domains	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	UBA-like	1	1
Retrovirus capsid dimerization domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Tudor/PWWP/MBT	BRCT domain	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
LDL receptor-like module	Family A G protein-coupled receptor-like	1	1
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	1	1
Nucleotidylyl transferase	C-terminal domain of ProRS	1	1
DBL homology domain (DH-domain)	WD40 repeat-like	1	1
ARID-like	ARM repeat	1	1
C-type lectin-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
CBS-domain pair	CBS-domain pair	1	1
PRP4-like	WD40 repeat-like	1	1
B-box zinc-binding domain	Fibronectin type III	1	1
P-loop containing nucleoside triphosphate hydrolases	SH2 domain	1	1
PDZ domain-like	EF-hand	1	1
FYVE/PHD zinc finger	Acyl-CoA N-acyltransferases (Nat)	1	1
Calcyclin-binding protein-like	HSP20-like chaperones	1	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	1	1
RNA-binding domain, RBD	Formin homology 2 domain (FH2 domain)	1	1
Protease propeptides/inhibitors	Galactose-binding domain-like	1	1
Actin-like ATPase domain	AF1104-like	1	1
Thioredoxin-like	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
PRTase-like	Ribulose-phoshate binding barrel	1	1
mRNA decapping enzyme DcpS N-terminal domain	HIT-like	1	1
L domain-like	Trypsin-like serine proteases	1	1
ENT-like	Bromodomain	1	1
CCHHC domain	SAM/Pointed domain	1	1
ARM repeat	SAM/Pointed domain	1	1
Epsilon subunit of F1F0-ATP synthase N-terminal domain	Epsilon subunit of F1F0-ATP synthase C-terminal domain	1	1
EF-hand	Immunoglobulin	1	1
beta-beta-alpha zinc fingers	P-loop containing nucleoside triphosphate hydrolases	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	DEATH domain	1	1
Thioredoxin-like	NHL repeat	1	1
SH3-domain	Immunoglobulin	1	1
RNA-binding domain, RBD	DPP6 N-terminal domain-like	1	1
BPTI-like	Immunoglobulin	1	1
PH domain-like	Glycolipid transfer protein, GLTP	1	1
L domain-like	PP2C-like	1	1
SH2 domain	Ankyrin repeat	1	1
FAD/NAD(P)-binding domain	NAD(P)-binding Rossmann-fold domains	1	1
RING/U-box	NRDP1 C-terminal domain-like	1	1
Rhodanese/Cell cycle control phosphatase	Cysteine proteinases	1	1
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	1	1
Clavaminate synthase-like	EF-hand	1	1
Ankyrin repeat	RCC1/BLIP-II	1	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	1	1
CCCH zinc finger	Retrovirus zinc finger-like domains	1	1
beta-beta-alpha zinc fingers	Ribonuclease H-like	1	1
G protein-binding domain	PH domain-like	1	1
PIN domain-like	Nucleic acid-binding proteins	1	1
FYVE/PHD zinc finger	RNI-like	1	1
MIT domain	Cysteine proteinases	1	1
Chaperone J-domain	Homeodomain-like	1	1
Invertebrate chitin-binding proteins	Carbohydrate-binding domain	1	1
SAP domain	P-loop containing nucleoside triphosphate hydrolases	1	1
UBA-like	Tudor/PWWP/MBT	1	1
SMAD/FHA domain	RING/U-box	1	1
EF-hand	Rhomboid-like	1	1
PAH2 domain	Homeodomain-like	1	1
Complement control module/SCR domain	SRCR-like	1	1
Nqo1 middle domain-like	Nqo1C-terminal domain-like	1	1
PDZ domain-like	Ras GEF	1	1
ARM repeat	Fibronectin type III	1	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	1	1
Kazal-type serine protease inhibitors	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
P-loop containing nucleoside triphosphate hydrolases	Fzo-like conserved region	1	1
HLH, helix-loop-helix DNA-binding domain	beta-sandwich domain of Sec23/24	1	1
WD40 repeat-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
ARM repeat	Lipovitellin-phosvitin complex, superhelical domain	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
Thioesterase/thiol ester dehydrase-isomerase	SCP-like	1	1
Plexin repeat	Plexin repeat	1	1
Ribosomal protein S5 domain 2-like	HMG-box	1	1
FYVE/PHD zinc finger	BRK domain-like	1	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Pyrimidine nucleoside phosphorylase C-terminal domain	1	1
Somatomedin B domain	Family A G protein-coupled receptor-like	1	1
Inhibitor of apoptosis (IAP) repeat	Quinoprotein alcohol dehydrogenase-like	1	1
R3H domain	Ribonuclease H-like	1	1
SEA domain	LDL receptor-like module	1	1
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	1	1
FYVE/PHD zinc finger	SMAD/FHA domain	1	1
UBA-like	XPC-binding domain	1	1
Homeodomain-like	Creatinase/prolidase N-terminal domain	1	1
RUN domain-like	PX domain	1	1
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	1	1
Growth factor receptor domain	(Phosphotyrosine protein) phosphatases II	1	1
ARM repeat	Cystine-knot cytokines	1	1
PheT/TilS domain	Class II aaRS and biotin synthetases	1	1
USP8 N-terminal domain-like	Rhodanese/Cell cycle control phosphatase	1	1
WWE domain	Domain of poly(ADP-ribose) polymerase	1	1
Leech antihemostatic proteins	Leech antihemostatic proteins	1	1
Zinc beta-ribbon	Zinc beta-ribbon	1	1
Dihydropteroate synthetase-like	Methionine synthase domain	1	1
PA domain	RING/U-box	1	1
B-box zinc-binding domain	Tudor/PWWP/MBT	1	1
Sema domain	TSP-1 type 1 repeat	1	1
DNA-glycosylase	Nudix	1	1
TPR-like	PIN domain-like	1	1
vWA-like	Concanavalin A-like lectins/glucanases	1	1
WWE domain	WGR domain-like	1	1
BRK domain-like	BRK domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	POZ domain	1	1
Galactose mutarotase-like	Galactose mutarotase-like	1	1
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	1	1
beta-beta-alpha zinc fingers	TRAF domain-like	1	1
Kelch motif	Growth factor receptor domain	1	1
Tropomyosin	beta-beta-alpha zinc fingers	1	1
WWE domain	WWE domain	1	1
Homocysteine S-methyltransferase	Methionine synthase activation domain-like	1	1
FYVE/PHD zinc finger	Concanavalin A-like lectins/glucanases	1	1
Metalloproteases ("zincins"), catalytic domain	ARM repeat	1	1
YjgF-like	YjgF-like	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Voltage-gated potassium channels	1	1
RuvA domain 2-like	WD40 repeat-like	1	1
TRAF domain-like	PDZ domain-like	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
R3H domain	AN1-like Zinc finger	1	1
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	1	1
Growth factor receptor domain	Notch domain	1	1
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
PLP-binding barrel	Alanine racemase C-terminal domain-like	1	1
Alpha subunit of glutamate synthase, C-terminal domain	alpha-helical ferredoxin	1	1
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	1	1
PYP-like sensor domain (PAS domain)	Protein kinase-like (PK-like)	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	NagB/RpiA/CoA transferase-like	1	1
F-box domain	SMI1/KNR4-like	1	1
HBS1-like domain	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	1	1
Homocysteine S-methyltransferase	Cobalamin (vitamin B12)-binding domain	1	1
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	1	1
Ubiquitin-like	HAD-like	1	1
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	1	1
CalX-like	C-type lectin-like	1	1
SH3-domain	PLC-like phosphodiesterases	1	1
HR1 repeat	PDZ domain-like	1	1
Amidase signature (AS) enzymes	Amidase signature (AS) enzymes	1	1
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	1	1
Calponin-homology domain, CH-domain	Plakin repeat	1	1
UBC-like	UBA-like	1	1
ARM repeat	POZ domain	1	1
EF-hand	Riboflavin synthase domain-like	1	1
SH3-domain	SAM/Pointed domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ATP-dependent DNA ligase DNA-binding domain	1	1
USP8 N-terminal domain-like	WW domain	1	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	1	1
ARID-like	Clavaminate synthase-like	1	1
WD40 repeat-like	Bromodomain	1	1
G protein-binding domain	Cysteine-rich domain	1	1
Staphylococcal nuclease	Staphylococcal nuclease	1	1
PUG domain-like	Galactose-binding domain-like	1	1
Activator of Hsp90 ATPase, Aha1	Bet v1-like	1	1
Bet v1-like	Bet v1-like	1	1
Single hybrid motif	Formin homology 2 domain (FH2 domain)	1	1
TAZ domain	Kix domain of CBP (creb binding protein)	1	1
N-terminal domain of cbl (N-cbl)	EF-hand	1	1
Hypothetical protein SAV1430	Fe-S cluster assembly (FSCA) domain-like	1	1
Galactose-binding domain-like	Kelch motif	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Protein kinase-like (PK-like)	1	1
SH2 domain	Ras GEF	1	1
UBC-like	LigT-like	1	1
EF-hand	DUSP-like	1	1
Formin homology 2 domain (FH2 domain)	SAM/Pointed domain	1	1
CRAL/TRIO domain	GTPase activation domain, GAP	1	1
Periplasmic binding protein-like II	Nucleotide cyclase	1	1
Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	1	1
Ribonuclease H-like	Zinc finger domain of DNA polymerase-alpha	1	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	1	1
GFP-like	EGF/Laminin	1	1
TRAF domain-like	NRDP1 C-terminal domain-like	1	1
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	1	1
TSP-1 type 1 repeat	BPTI-like	1	1
EF-hand	Isochorismatase-like hydrolases	1	1
Starch-binding domain-like	Starch-binding domain-like	1	1
FYVE/PHD zinc finger	PUA domain-like	1	1
Methionine synthase domain	Methionine synthase activation domain-like	1	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	1	1
Immunoglobulin	Heme-dependent peroxidases	1	1
Ankyrin repeat	Family A G protein-coupled receptor-like	1	1
Heme-dependent peroxidases	EF-hand	1	1
Serine protease inhibitors	EGF/Laminin	1	1
Ubiquitin-like	NAD kinase/diacylglycerol kinase-like	1	1
beta-sandwich domain of Sec23/24	WD40 repeat-like	1	1
Nucleotidylyl transferase	Class II aaRS ABD-related	1	1
Kazal-type serine protease inhibitors	EF-hand	1	1
Calcium-dependent phosphotriesterase	SOCS box-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	vWA-like	1	1
BRCA2 helical domain	BRCA2 tower domain	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Fibronectin type III	1	1
GIY-YIG endonuclease	RING/U-box	1	1
PH domain-like	Family A G protein-coupled receptor-like	1	1
IP3 receptor type 1 binding core, domain 2	Concanavalin A-like lectins/glucanases	1	1
Calponin-homology domain, CH-domain	SH3-domain	1	1
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	1	1
P-loop containing nucleoside triphosphate hydrolases	GTPase activation domain, GAP	1	1
Ribonuclease H-like	CCCH zinc finger	1	1
Histone-fold	Ras GEF	1	1
Quinoprotein alcohol dehydrogenase-like	Prefoldin	1	1
PH domain-like	Cullin repeat-like	1	1
RNA-binding domain, RBD	SPOC domain-like	1	1
Calponin-homology domain, CH-domain	P-loop containing nucleoside triphosphate hydrolases	1	1
beta-sandwich domain of Sec23/24	Formin homology 2 domain (FH2 domain)	1	1
FYVE/PHD zinc finger	Rabenosyn-5 Rab-binding domain-like	1	1
FabD/lysophospholipase-like	FabD/lysophospholipase-like	1	1
Ubiquitin-like	AN1-like Zinc finger	1	1
ClpS-like	"Winged helix" DNA-binding domain	1	1
USP8 N-terminal domain-like	Cysteine proteinases	1	1
Cadherin-like	Growth factor receptor domain	1	1
Kazal-type serine protease inhibitors	Fibronectin type III	1	1
DNA/RNA polymerases	FYVE/PHD zinc finger	1	1
Mib/herc2 domain-like	Spermadhesin, CUB domain	1	1
Glycosyl hydrolase domain	Glycosyl hydrolase domain	1	1
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1