Domain combination pairs in Cryptosporidium parvum Iowa II

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

527 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	52	30
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	22	14
RNA-binding domain, RBD	RNA-binding domain, RBD	18	10
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	17	9
Actin-like ATPase domain	Actin-like ATPase domain	16	5
ABC transporter transmembrane region	ABC transporter transmembrane region	15	7
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	13	7
Calcium ATPase, transduction domain A	HAD-like	12	6
HAD-like	Calcium ATPase, transmembrane domain M	12	6
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	10	4
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	10	4
TPR-like	TPR-like	10	7
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	10	5
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	10	4
Protein kinase-like (PK-like)	EF-hand	10	7
GroEL equatorial domain-like	GroEL-intermediate domain like	9	2
GroEL-intermediate domain like	GroEL apical domain-like	9	2
GroEL equatorial domain-like	GroEL apical domain-like	9	2
ARM repeat	ARM repeat	9	7
TSP-1 type 1 repeat	TSP-1 type 1 repeat	8	7
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	7	5
Thioredoxin-like	Thioredoxin-like	6	6
WD40 repeat-like	WD40 repeat-like	6	5
FYVE/PHD zinc finger	FYVE/PHD zinc finger	6	5
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	6	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	5	5
Homeodomain-like	Homeodomain-like	5	5
Ubiquitin-like	UBA-like	5	4
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	5	5
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	5	3
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	5	3
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	5	2
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	5	3
Nucleic acid-binding proteins	Nucleic acid-binding proteins	5	5
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	4	3
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	4	2
Protein kinase-like (PK-like)	ARM repeat	4	4
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	4	3
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	4	3
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	4	4
Cyclin-like	Cyclin-like	4	4
Cullin repeat-like	Cullin homology domain	4	3
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	3	3
Growth factor receptor domain	Growth factor receptor domain	3	3
Translation proteins	EF-G C-terminal domain-like	3	3
Cullin homology domain	"Winged helix" DNA-binding domain	3	2
beta-sandwich domain of Sec23/24	Zn-finger domain of Sec23/24	3	3
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	3	1
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	3	3
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	3
cAMP-binding domain-like	cAMP-binding domain-like	3	3
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	3	2
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	3	3
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	3	1
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	3	1
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	3	2
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	3	2
P-loop containing nucleoside triphosphate hydrolases	TGS-like	3	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	3	2
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	3	2
Zn-finger domain of Sec23/24	vWA-like	3	3
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	3
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	3	2
EGF/Laminin	EGF/Laminin	3	3
GroES-like	NAD(P)-binding Rossmann-fold domains	3	3
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	3	3
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	3	2
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	3	2
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	3	2
EF-G C-terminal domain-like	EF-G C-terminal domain-like	3	3
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	3	3
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	3	3
Flavoproteins	Riboflavin synthase domain-like	3	3
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	3
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	3	2
RING/U-box	SMAD/FHA domain	3	3
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	3	3
TSP-1 type 1 repeat	EGF/Laminin	3	2
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	3	2
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	3
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	3	3
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	3	2
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	3	3
EF-hand	EF-hand	3	3
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	3	2
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	3
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	3	2
Translation proteins	Ribosomal protein S5 domain 2-like	3	3
vWA-like	Helical domain of Sec23/24	3	3
RCC1/BLIP-II	RCC1/BLIP-II	3	3
Ribonuclease H-like	DNA/RNA polymerases	3	3
CCCH zinc finger	CCCH zinc finger	3	2
beta-sandwich domain of Sec23/24	vWA-like	3	3
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	3	1
Cullin repeat-like	"Winged helix" DNA-binding domain	3	2
Sec63 N-terminal domain-like	E set domains	3	3
SNARE-like	SNARE fusion complex	3	2
Thiolase-like	NAD(P)-binding Rossmann-fold domains	2	2
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	2	1
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
HAD-like	BRCT domain	2	1
P-loop containing nucleoside triphosphate hydrolases	RCC1/BLIP-II	2	2
GroES-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
Translation proteins SH3-like domain	Nucleic acid-binding proteins	2	2
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	2	2
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	2	2
Glycerol-3-phosphate (1)-acyltransferase	Glycerol-3-phosphate (1)-acyltransferase	2	2
ACP-like	FabD/lysophospholipase-like	2	2
FabD/lysophospholipase-like	FabD/lysophospholipase-like	2	2
FabD/lysophospholipase-like	GroES-like	2	2
UBC-like	Protein kinase-like (PK-like)	2	1
Acetyl-CoA synthetase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
ACP-like	GroES-like	2	2
Nucleotidylyl transferase	Ribosomal protein L25-like	2	2
EGF/Laminin	Growth factor receptor domain	2	2
Ricin B-like lectins	LCCL domain	2	1
GroES-like	GroES-like	2	2
Thiolase-like	Thiolase-like	2	2
Galactose-binding domain-like	Fibrinogen C-terminal domain-like	2	1
ACP-like	NAD(P)-binding Rossmann-fold domains	2	2
Thiolase-like	FabD/lysophospholipase-like	2	2
ADC-like	P-loop containing nucleoside triphosphate hydrolases	2	2
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	2	1
POZ domain	Kelch motif	2	2
E set domains	(Trans)glycosidases	2	2
PUG domain-like	UBA-like	2	2
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	2	2
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	2	2
ACP-like	Thiolase-like	2	2
TATA-box binding protein-like	TATA-box binding protein-like	2	2
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	2	2
HCP-like	HCP-like	2	2
Ricin B-like lectins	Fibrinogen C-terminal domain-like	2	1
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	2	2
Fibrinogen C-terminal domain-like	LCCL domain	2	1
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	2	1
Zinc beta-ribbon	Cyclin-like	2	2
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	2	2
NAD(P)-binding Rossmann-fold domains	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
DHS-like NAD/FAD-binding domain	NAD(P)-binding Rossmann-fold domains	2	1
ACP-like	ACP-like	2	2
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	2	2
Kazal-type serine protease inhibitors	Kazal-type serine protease inhibitors	2	2
ARM repeat	Clathrin adaptor appendage domain	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	2	2
(Trans)glycosidases	Glycosyl hydrolase domain	2	2
RING/U-box	Cysteine proteinases	2	2
Restriction endonuclease-like	RuvA domain 2-like	2	1
Kelch motif	Kelch motif	2	2
Class II aaRS and biotin synthetases	ThrRS/AlaRS common domain	2	2
Acetyl-CoA synthetase-like	NAD(P)-binding Rossmann-fold domains	2	2
Phospholipase D/nuclease	Phospholipase D/nuclease	2	1
Nucleotide cyclase	Nucleotide cyclase	2	2
Chromo domain-like	Chromo domain-like	2	2
Translational machinery components	L30e-like	2	2
Ubiquitin-like	Ubiquitin-like	2	2
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	SAM/Pointed domain	2	2
DHS-like NAD/FAD-binding domain	Formate/glycerate dehydrogenase catalytic domain-like	2	1
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	2	2
P-loop containing nucleoside triphosphate hydrolases	Glucocorticoid receptor-like (DNA-binding domain)	2	2
Galactose-binding domain-like	LCCL domain	2	1
Thiolase-like	GroES-like	2	2
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	2	2
Ricin B-like lectins	Galactose-binding domain-like	2	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Protein kinase-like (PK-like)	2	2
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	2	2
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	2	2
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	2	2
Phosphofructokinase	Phosphofructokinase	2	1
ACP-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
FabD/lysophospholipase-like	NAD(P)-binding Rossmann-fold domains	2	2
Dipeptidyl peptidase I (cathepsin C), exclusion domain	Cysteine proteinases	2	2
DNA clamp	DNA clamp	2	1
Ubiquitin-like	Zn-binding ribosomal proteins	2	1
Acetyl-CoA synthetase-like	Thiolase-like	2	2
P-loop containing nucleoside triphosphate hydrolases	RING/U-box	2	2
Acetyl-CoA synthetase-like	FabD/lysophospholipase-like	2	2
Acetyl-CoA synthetase-like	GroES-like	2	2
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	2	2
SAM/Pointed domain	Protein kinase-like (PK-like)	2	2
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	2	2
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	2	1
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	2	2
Chaperone J-domain	Thioredoxin-like	2	2
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	2	2
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	2	1
Acetyl-CoA synthetase-like	ACP-like	2	2
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	2	2
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	2	2
FYVE/PHD zinc finger	SET domain	2	2
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	2	2
P-loop containing nucleoside triphosphate hydrolases	E set domains	1	1
ARM repeat	Subdomain of clathrin and coatomer appendage domain	1	1
RNA-binding domain, RBD	PABC (PABP) domain	1	1
Putative DNA-binding domain	Putative DNA-binding domain	1	1
E set domains	E set domains	1	1
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	1	1
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	1	1
Concanavalin A-like lectins/glucanases	Amine oxidase catalytic domain	1	1
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	1	1
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	1	1
Retrovirus zinc finger-like domains	RING/U-box	1	1
(Phosphotyrosine protein) phosphatases II	PUG domain-like	1	1
Acyl-CoA binding protein	Ankyrin repeat	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	1	1
Thiamin diphosphate-binding fold (THDP-binding)	Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	1	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	1	1
GST C-terminal domain-like	Nucleic acid-binding proteins	1	1
Surp module (SWAP domain)	Surp module (SWAP domain)	1	1
(Trans)glycosidases	(Trans)glycosidases	1	1
RING/U-box	WD40 repeat-like	1	1
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	1	1
Translation proteins	ThrRS/AlaRS common domain	1	1
ARM repeat	"Winged helix" DNA-binding domain	1	1
EF-hand	Metallo-dependent phosphatases	1	1
CCCH zinc finger	WD40 repeat-like	1	1
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1	1
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	1	1
YbaK/ProRS associated domain	C-terminal domain of ProRS	1	1
Initiation factor IF2/eIF5b, domain 3	Translation proteins	1	1
Carbamate kinase-like	PUA domain-like	1	1
Ubiquitin-like	Acid proteases	1	1
WD40 repeat-like	Quinoprotein alcohol dehydrogenase-like	1	1
t-snare proteins	SNARE fusion complex	1	1
Trimeric LpxA-like enzymes	ARM repeat	1	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	1	1
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	1	1
Cdc48 domain 2-like	RING/U-box	1	1
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Thiamin diphosphate-binding fold (THDP-binding)	Flavoproteins	1	1
HAD-like	HAD-like	1	1
Ankyrin repeat	Arginase/deacetylase	1	1
Ankyrin repeat	TPR-like	1	1
SMAD/FHA domain	BRCT domain	1	1
RCC1/BLIP-II	Chromo domain-like	1	1
Mannose 6-phosphate receptor domain	YccV-like	1	1
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	1	1
Thioredoxin-like	FAD-dependent thiol oxidase	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
"Winged helix" DNA-binding domain	E set domains	1	1
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	1	1
PreATP-grasp domain	Rudiment single hybrid motif	1	1
TPR-like	Activator of Hsp90 ATPase, Aha1	1	1
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	1	1
4Fe-4S ferredoxins	Riboflavin synthase domain-like	1	1
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	1	1
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	1	1
Cyclophilin-like	RNA-binding domain, RBD	1	1
Creatinase/aminopeptidase	PH domain-like	1	1
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	SRCR-like	1	1
MIT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	1	1
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	1	1
ALDH-like	Dehydroquinate synthase-like	1	1
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	LCCL domain	1	1
Kelch motif	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Calcium ATPase, transduction domain A	Nucleotide cyclase	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	1	1
GST C-terminal domain-like	eEF-1beta-like	1	1
FYSH domain	beta-beta-alpha zinc fingers	1	1
WD40 repeat-like	Nucleoporin domain	1	1
NTF2-like	RNA-binding domain, RBD	1	1
Starch-binding domain-like	Protein kinase-like (PK-like)	1	1
Taf5 N-terminal domain-like	WD40 repeat-like	1	1
RING/U-box	RNA-binding domain, RBD	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	1	1
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	1	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	1	1
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	1	1
Putative isomerase YbhE	WD40 repeat-like	1	1
ADC-like	Cdc48 domain 2-like	1	1
EF-hand	PLC-like phosphodiesterases	1	1
PLP-dependent transferases	Adenine nucleotide alpha hydrolases-like	1	1
Trimeric LpxA-like enzymes	HAD-like	1	1
(Trans)glycosidases	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
P-loop containing nucleoside triphosphate hydrolases	RNA-binding domain, RBD	1	1
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	1	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	1	1
RING/U-box	Ran binding protein zinc finger-like	1	1
ENTH/VHS domain	ARM repeat	1	1
Hect, E3 ligase catalytic domain	Hect, E3 ligase catalytic domain	1	1
cAMP-binding domain-like	Protein kinase-like (PK-like)	1	1
PriA/YqbF domain	GINS helical bundle-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
Dom34/Pelota N-terminal domain-like	L30e-like	1	1
Ankyrin repeat	Bromodomain	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	Probable ACP-binding domain of malonyl-CoA ACP transacylase	1	1
POZ domain	Skp1 dimerisation domain-like	1	1
RNA-binding domain, RBD	Clavaminate synthase-like	1	1
ClpP/crotonase	ClpP/crotonase	1	1
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	1	1
Starch-binding domain-like	EF-hand	1	1
CYTH-like phosphatases	S-adenosyl-L-methionine-dependent methyltransferases	1	1
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
LCCL domain	SRCR-like	1	1
Chaperone J-domain	Homeodomain-like	1	1
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	1	1
YbaK/ProRS associated domain	Class II aaRS ABD-related	1	1
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	1	1
Thiamin diphosphate-binding fold (THDP-binding)	4Fe-4S ferredoxins	1	1
Chaperone J-domain	E set domains	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
PUA domain-like	eIF1-like	1	1
SMAD/FHA domain	SMAD/FHA domain	1	1
TK C-terminal domain-like	4Fe-4S ferredoxins	1	1
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	1	1
Ribokinase-like	Ribokinase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	1	1
FYVE/PHD zinc finger	Bromodomain	1	1
Eukaryotic type KH-domain (KH-domain type I)	Retrovirus zinc finger-like domains	1	1
alpha/beta-Hydrolases	Galactose-binding domain-like	1	1
DNase I-like	DNase I-like	1	1
DNA polymerase beta, N-terminal domain-like	Restriction endonuclease-like	1	1
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	1	1
Concanavalin A-like lectins/glucanases	Hect, E3 ligase catalytic domain	1	1
Rudiment single hybrid motif	Single hybrid motif	1	1
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	1	1
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	HAD-like	1	1
Nucleotidylyl transferase	Nucleotidylyl transferase	1	1
MFS general substrate transporter	MFS general substrate transporter	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	1	1
PreATP-grasp domain	ClpP/crotonase	1	1
SRCR-like	SRCR-like	1	1
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	1	1
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	1	1
Class II aaRS ABD-related	C-terminal domain of ProRS	1	1
Activator of Hsp90 ATPase, Aha1	Activator of Hsp90 ATPase, Aha1	1	1
Ankyrin repeat	PH domain-like	1	1
RNI-like	RNI-like	1	1
PLP-dependent transferases	PLP-dependent transferases	1	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	1	1
TRAF domain-like	Cysteine proteinases	1	1
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
RNA-binding domain, RBD	WW domain	1	1
Kelch motif	Metallo-dependent phosphatases	1	1
TPR-like	RNA-binding domain, RBD	1	1
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
(Trans)glycosidases	Six-hairpin glycosidases	1	1
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	1	1
TRAF domain-like	ARM repeat	1	1
EF-hand	cAMP-binding domain-like	1	1
PH domain-like	BEACH domain	1	1
Ankyrin repeat	Ankyrin repeat	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	1	1
CCCH zinc finger	RING/U-box	1	1
Dihydrofolate reductase-like	Thymidylate synthase/dCMP hydroxymethylase	1	1
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Growth factor receptor domain	Hairpin loop containing domain-like	1	1
YbaK/ProRS associated domain	Class II aaRS and biotin synthetases	1	1
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
TRAF domain-like	POZ domain	1	1
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	1	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	1	1
WD40 repeat-like	Cysteine proteinases	1	1
Fe-S cluster assembly (FSCA) domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
vWA-like	Cysteine-rich domain	1	1
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	1	1
Chaperone J-domain	CSL zinc finger	1	1
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	1	1
Ankyrin repeat	Hect, E3 ligase catalytic domain	1	1
tRNA-binding arm	Class II aaRS and biotin synthetases	1	1
TK C-terminal domain-like	Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	1	1
SET domain	Ankyrin repeat	1	1
Enolase N-terminal domain-like	Enolase C-terminal domain-like	1	1
PR-1-like	PR-1-like	1	1
Ribonuclease H-like	Ribonuclease H-like	1	1
ARM repeat	RING/U-box	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
CRAL/TRIO domain	GTPase activation domain, GAP	1	1
Cysteine proteinases	Ribonuclease H-like	1	1
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	1	1
CCCH zinc finger	RNA-binding domain, RBD	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	1	1
Nucleic acid-binding proteins	TPR-like	1	1
WWE domain	RING/U-box	1	1
PUG domain-like	Ubiquitin-like	1	1
Clathrin heavy-chain terminal domain	ARM repeat	1	1
CHY zinc finger-like	RING/U-box	1	1
Macro domain-like	Zn-dependent exopeptidases	1	1
Adenine nucleotide alpha hydrolases-like	Adenine nucleotide alpha hydrolases-like	1	1
Zinc beta-ribbon	Zinc beta-ribbon	1	1
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	1	1
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	1	1
PH domain-like	EF-hand	1	1
Pre-PUA domain	PUA domain-like	1	1
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	1	1
Protein kinase-like (PK-like)	KA1-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
HMA, heavy metal-associated domain	HAD-like	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
UBA-like	XPC-binding domain	1	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	1	1
SRCR-like	Concanavalin A-like lectins/glucanases	1	1
Ankyrin repeat	Complement control module/SCR domain	1	1
Rudiment single hybrid motif	ClpP/crotonase	1	1
Glucocorticoid receptor-like (DNA-binding domain)	RING/U-box	1	1
Ubiquitin-like	XPC-binding domain	1	1
Acid proteases	UBA-like	1	1
WD40 repeat-like	Ribonuclease H-like	1	1
UBA-like	UBA-like	1	1
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	1	1
PreATP-grasp domain	Single hybrid motif	1	1
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	1	1
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	1	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	1	1
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	1	1
PAH2 domain	PAH2 domain	1	1
Ribonuclease H-like	HRDC-like	1	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	1	1
Homeodomain-like	CHY zinc finger-like	1	1
TK C-terminal domain-like	Riboflavin synthase domain-like	1	1
Chromo domain-like	Bromodomain	1	1
TPR-like	Formin homology 2 domain (FH2 domain)	1	1
Voltage-gated potassium channels	E set domains	1	1
E set domains	Six-hairpin glycosidases	1	1
RING/U-box	FYVE/PHD zinc finger	1	1
Chaperone J-domain	Sec63 N-terminal domain-like	1	1
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	1	1
dsRNA-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
alpha/beta knot	Nucleic acid-binding proteins	1	1
Bromodomain	SET domain	1	1
PH domain-like	Oxysterol-binding protein-like	1	1
GMP synthetase C-terminal dimerisation domain	GMP synthetase C-terminal dimerisation domain	1	1
Ubiquitin-like	Cysteine proteinases	1	1
4Fe-4S ferredoxins	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
WD40 repeat-like	Cyclophilin-like	1	1
TK C-terminal domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
EF-hand	SAICAR synthase-like	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Concanavalin A-like lectins/glucanases	1	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	1	1
CHY zinc finger-like	Zinc hairpin stack	1	1
"Winged helix" DNA-binding domain	Zinc beta-ribbon	1	1
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	1	1
Ankyrin repeat	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Flavoproteins	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	1	1
ADP-ribosylation	B-box zinc-binding domain	1	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	1	1
Single hybrid motif	ClpP/crotonase	1	1
Calcium ATPase, transmembrane domain M	Nucleotide cyclase	1	1
RNA-binding domain, RBD	Eukaryotic type KH-domain (KH-domain type I)	1	1
4Fe-4S ferredoxins	Flavoproteins	1	1
Bromodomain	Bromodomain	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	1	1
Hypothetical protein AF0491, middle domain	beta-beta-alpha zinc fingers	1	1
WD40 repeat-like	Nitrous oxide reductase, N-terminal domain	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
TSP-1 type 1 repeat	Kringle-like	1	1
P-loop containing nucleoside triphosphate hydrolases	EF-hand	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
Thiamin diphosphate-binding fold (THDP-binding)	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
BRCT domain	post-AAA+ oligomerization domain-like	1	1
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	1	1
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	1	1
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	1	1
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	1	1
FYVE/PHD zinc finger	ARM repeat	1	1
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	1	1
SET domain	HIT/MYND zinc finger-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	1	1
Cullin repeat-like	Cullin repeat-like	1	1
Nucleotide-diphospho-sugar transferases	ARM repeat	1	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	1	1
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	1	1
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	1	1
TPR-like	Metallo-dependent phosphatases	1	1
Thiamin diphosphate-binding fold (THDP-binding)	Riboflavin synthase domain-like	1	1
ARM repeat	P-loop containing nucleoside triphosphate hydrolases	1	1
PX domain	WD40 repeat-like	1	1
GST C-terminal domain-like	eEF1-gamma domain	1	1
PH domain-like	PLC-like phosphodiesterases	1	1
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Riboflavin synthase domain-like	1	1
PK beta-barrel domain-like	PK C-terminal domain-like	1	1
SNARE fusion complex	SNARE fusion complex	1	1
ThrRS/AlaRS common domain	Nucleotidylyl transferase	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	4Fe-4S ferredoxins	1	1
AN1-like Zinc finger	AN1-like Zinc finger	1	1
LCCL domain	LCCL domain	1	1
Galactose mutarotase-like	(Trans)glycosidases	1	1
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	1	1
Activating enzymes of the ubiquitin-like proteins	Rhodanese/Cell cycle control phosphatase	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Oligoxyloglucan reducing end-specific cellobiohydrolase	1	1
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	1	1
UBC-like	UBA-like	1	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	1	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	1	1
E set domains	Glycosyl hydrolase domain	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
LCCL domain	Concanavalin A-like lectins/glucanases	1	1
Sec7 domain	Ypt/Rab-GAP domain of gyp1p	1	1
TK C-terminal domain-like	Flavoproteins	1	1
Pseudouridine synthase	PUA domain-like	1	1
EGF/Laminin	Hairpin loop containing domain-like	1	1
PRP4-like	WD40 repeat-like	1	1
RING/U-box	Homeodomain-like	1	1
Dcp2 domain-like	Nudix	1	1
WD40 repeat-like	Bromodomain	1	1
Zinc hairpin stack	RING/U-box	1	1

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