Domain combination pairs in Cryptosporidium parvum Iowa II

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

527 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	52	30
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	22	14
RNA-binding domain, RBD	RNA-binding domain, RBD	18	10
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	17	9
Actin-like ATPase domain	Actin-like ATPase domain	16	5
ABC transporter transmembrane region	ABC transporter transmembrane region	15	7
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	13	7
Calcium ATPase, transduction domain A	HAD-like	12	6
HAD-like	Calcium ATPase, transmembrane domain M	12	6
Protein kinase-like (PK-like)	EF-hand	10	7
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	10	4
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	10	4
TPR-like	TPR-like	10	7
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	10	4
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	10	5
GroEL-intermediate domain like	GroEL apical domain-like	9	2
GroEL equatorial domain-like	GroEL-intermediate domain like	9	2
GroEL equatorial domain-like	GroEL apical domain-like	9	2
ARM repeat	ARM repeat	9	7
TSP-1 type 1 repeat	TSP-1 type 1 repeat	8	7
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	7	5
WD40 repeat-like	WD40 repeat-like	6	5
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	6	1
FYVE/PHD zinc finger	FYVE/PHD zinc finger	6	5
Thioredoxin-like	Thioredoxin-like	6	6
Homeodomain-like	Homeodomain-like	5	5
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	5	2
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	5	3
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	5	3
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	5	5
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	5	5
Nucleic acid-binding proteins	Nucleic acid-binding proteins	5	5
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	5	3
UBA-like	Ubiquitin-like	5	4
ARM repeat	Protein kinase-like (PK-like)	4	4
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	4	3
Cyclin-like	Cyclin-like	4	4
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	4	4
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	4	3
Cullin repeat-like	Cullin homology domain	4	3
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	4	3
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	4	2
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	3	2
Translation proteins	EF-G C-terminal domain-like	3	3
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	3
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	3	3
P-loop containing nucleoside triphosphate hydrolases	TGS-like	3	1
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	3
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	3	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	3	3
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	3	2
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	3	3
Flavoproteins	Riboflavin synthase domain-like	3	3
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	3
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	3	2
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	3	2
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	3	3
EF-hand	EF-hand	3	3
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	3	2
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	3	1
beta-sandwich domain of Sec23/24	vWA-like	3	3
GroES-like	NAD(P)-binding Rossmann-fold domains	3	3
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	3	3
Ribonuclease H-like	DNA/RNA polymerases	3	3
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	3	2
CCCH zinc finger	CCCH zinc finger	3	2
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	3	2
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	3	1
cAMP-binding domain-like	cAMP-binding domain-like	3	3
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	3	2
Cullin repeat-like	"Winged helix" DNA-binding domain	3	2
EF-G C-terminal domain-like	EF-G C-terminal domain-like	3	3
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	3	2
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	3	2
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	3	3
Zn-finger domain of Sec23/24	vWA-like	3	3
Growth factor receptor domain	Growth factor receptor domain	3	3
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	3	2
RCC1/BLIP-II	RCC1/BLIP-II	3	3
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	3
Sec63 N-terminal domain-like	E set domains	3	3
EGF/Laminin	EGF/Laminin	3	3
Translation proteins	Ribosomal protein S5 domain 2-like	3	3
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	3	1
vWA-like	Helical domain of Sec23/24	3	3
beta-sandwich domain of Sec23/24	Zn-finger domain of Sec23/24	3	3
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	3	1
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	3	3
RING/U-box	SMAD/FHA domain	3	3
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	3	2
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	3	3
TSP-1 type 1 repeat	EGF/Laminin	3	2
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	3
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	3	3
Cullin homology domain	"Winged helix" DNA-binding domain	3	2
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	3	2
SNARE-like	SNARE fusion complex	3	2
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	2	2
P-loop containing nucleoside triphosphate hydrolases	RCC1/BLIP-II	2	2
SAM/Pointed domain	Protein kinase-like (PK-like)	2	2
Acetyl-CoA synthetase-like	GroES-like	2	2
HCP-like	HCP-like	2	2
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	2	2
Acetyl-CoA synthetase-like	ACP-like	2	2
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	2	2
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	2	2
ARM repeat	Clathrin adaptor appendage domain	2	2
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	2	2
Galactose-binding domain-like	Fibrinogen C-terminal domain-like	2	1
FabD/lysophospholipase-like	NAD(P)-binding Rossmann-fold domains	2	2
Restriction endonuclease-like	RuvA domain 2-like	2	1
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	2	2
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Zinc beta-ribbon	Cyclin-like	2	2
Acetyl-CoA synthetase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
GroES-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	2	1
Kazal-type serine protease inhibitors	Kazal-type serine protease inhibitors	2	2
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	2	1
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
Dipeptidyl peptidase I (cathepsin C), exclusion domain	Cysteine proteinases	2	2
HAD-like	BRCT domain	2	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	SAM/Pointed domain	2	2
Acetyl-CoA synthetase-like	NAD(P)-binding Rossmann-fold domains	2	2
ACP-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	2	2
Kelch motif	Kelch motif	2	2
Ubiquitin-like	Zn-binding ribosomal proteins	2	1
ACP-like	FabD/lysophospholipase-like	2	2
Thiolase-like	Thiolase-like	2	2
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	2	2
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	2	1
RING/U-box	Cysteine proteinases	2	2
Thiolase-like	NAD(P)-binding Rossmann-fold domains	2	2
UBC-like	Protein kinase-like (PK-like)	2	1
Phospholipase D/nuclease	Phospholipase D/nuclease	2	1
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	2	2
(Trans)glycosidases	E set domains	2	2
FabD/lysophospholipase-like	GroES-like	2	2
Ricin B-like lectins	Fibrinogen C-terminal domain-like	2	1
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	2	2
Nucleotidylyl transferase	Ribosomal protein L25-like	2	2
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	2	2
P-loop containing nucleoside triphosphate hydrolases	RING/U-box	2	2
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	2	2
UBA-like	PUG domain-like	2	2
Thiolase-like	FabD/lysophospholipase-like	2	2
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Protein kinase-like (PK-like)	2	2
Chromo domain-like	Chromo domain-like	2	2
Acetyl-CoA synthetase-like	FabD/lysophospholipase-like	2	2
NAD(P)-binding Rossmann-fold domains	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
Chaperone J-domain	Thioredoxin-like	2	2
ACP-like	Thiolase-like	2	2
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	2	2
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	2	2
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	2	2
DNA clamp	DNA clamp	2	1
(Trans)glycosidases	Glycosyl hydrolase domain	2	2
Phosphofructokinase	Phosphofructokinase	2	1
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	2	2
Galactose-binding domain-like	LCCL domain	2	1
Nucleic acid-binding proteins	Translation proteins SH3-like domain	2	2
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	2	2
FYVE/PHD zinc finger	SET domain	2	2
Ricin B-like lectins	LCCL domain	2	1
Nucleotide cyclase	Nucleotide cyclase	2	2
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	2	2
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	2	2
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	2	2
Glycerol-3-phosphate (1)-acyltransferase	Glycerol-3-phosphate (1)-acyltransferase	2	2
ADC-like	P-loop containing nucleoside triphosphate hydrolases	2	2
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	2	1
Kelch motif	POZ domain	2	2
GroES-like	GroES-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	2	2
ACP-like	ACP-like	2	2
Acetyl-CoA synthetase-like	Thiolase-like	2	2
Ricin B-like lectins	Galactose-binding domain-like	2	1
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	2	2
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Glucocorticoid receptor-like (DNA-binding domain)	2	2
Translational machinery components	L30e-like	2	2
DHS-like NAD/FAD-binding domain	Formate/glycerate dehydrogenase catalytic domain-like	2	1
Thiolase-like	GroES-like	2	2
Fibrinogen C-terminal domain-like	LCCL domain	2	1
Growth factor receptor domain	EGF/Laminin	2	2
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	2	2
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	2	2
FabD/lysophospholipase-like	FabD/lysophospholipase-like	2	2
ACP-like	NAD(P)-binding Rossmann-fold domains	2	2
TATA-box binding protein-like	TATA-box binding protein-like	2	2
Ubiquitin-like	Ubiquitin-like	2	2
DHS-like NAD/FAD-binding domain	NAD(P)-binding Rossmann-fold domains	2	1
ACP-like	GroES-like	2	2
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	1	1
Ankyrin repeat	Arginase/deacetylase	1	1
TRAF domain-like	Cysteine proteinases	1	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	1	1
Ankyrin repeat	Hect, E3 ligase catalytic domain	1	1
ThrRS/AlaRS common domain	Nucleotidylyl transferase	1	1
SNARE fusion complex	SNARE fusion complex	1	1
CCCH zinc finger	WD40 repeat-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	RING/U-box	1	1
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	1	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	1	1
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
TRAF domain-like	ARM repeat	1	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
Putative DNA-binding domain	Putative DNA-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	1	1
Acyl-CoA binding protein	Ankyrin repeat	1	1
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Concanavalin A-like lectins/glucanases	Hect, E3 ligase catalytic domain	1	1
YbaK/ProRS associated domain	Class II aaRS and biotin synthetases	1	1
RNA-binding domain, RBD	Eukaryotic type KH-domain (KH-domain type I)	1	1
Nucleotide-diphospho-sugar transferases	ARM repeat	1	1
HAD-like	HAD-like	1	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	1	1
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	1	1
Activator of Hsp90 ATPase, Aha1	Activator of Hsp90 ATPase, Aha1	1	1
Calcium ATPase, transduction domain A	Nucleotide cyclase	1	1
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	1	1
E set domains	Six-hairpin glycosidases	1	1
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	1	1
RING/U-box	Ran binding protein zinc finger-like	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
Ankyrin repeat	Ankyrin repeat	1	1
Cdc48 domain 2-like	RING/U-box	1	1
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	1	1
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	1	1
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
CCCH zinc finger	RING/U-box	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	Probable ACP-binding domain of malonyl-CoA ACP transacylase	1	1
UBA-like	UBA-like	1	1
AN1-like Zinc finger	AN1-like Zinc finger	1	1
Adenine nucleotide alpha hydrolases-like	Adenine nucleotide alpha hydrolases-like	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Flavoproteins	1	1
EF-hand	Metallo-dependent phosphatases	1	1
ARM repeat	"Winged helix" DNA-binding domain	1	1
WD40 repeat-like	Nitrous oxide reductase, N-terminal domain	1	1
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	1	1
Translation proteins	ThrRS/AlaRS common domain	1	1
Activating enzymes of the ubiquitin-like proteins	Rhodanese/Cell cycle control phosphatase	1	1
CHY zinc finger-like	RING/U-box	1	1
Ribonuclease H-like	HRDC-like	1	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	1	1
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	1	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	1	1
PLP-dependent transferases	PLP-dependent transferases	1	1
PK beta-barrel domain-like	PK C-terminal domain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	1	1
ARM repeat	P-loop containing nucleoside triphosphate hydrolases	1	1
Initiation factor IF2/eIF5b, domain 3	Translation proteins	1	1
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	1	1
E set domains	Glycosyl hydrolase domain	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	1	1
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	1	1
Hypothetical protein AF0491, middle domain	beta-beta-alpha zinc fingers	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Protein kinase-like (PK-like)	KA1-like	1	1
WD40 repeat-like	Cysteine proteinases	1	1
CRAL/TRIO domain	GTPase activation domain, GAP	1	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	1	1
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	1	1
"Winged helix" DNA-binding domain	E set domains	1	1
POZ domain	Skp1 dimerisation domain-like	1	1
4Fe-4S ferredoxins	Riboflavin synthase domain-like	1	1
Thiamin diphosphate-binding fold (THDP-binding)	Riboflavin synthase domain-like	1	1
Ribokinase-like	Ribokinase-like	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Concanavalin A-like lectins/glucanases	1	1
TPR-like	Metallo-dependent phosphatases	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	1	1
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	1	1
Clathrin heavy-chain terminal domain	ARM repeat	1	1
SRCR-like	Concanavalin A-like lectins/glucanases	1	1
CCCH zinc finger	RNA-binding domain, RBD	1	1
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	1	1
MFS general substrate transporter	MFS general substrate transporter	1	1
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	1	1
RING/U-box	FYVE/PHD zinc finger	1	1
Ankyrin repeat	PH domain-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
YbaK/ProRS associated domain	Class II aaRS ABD-related	1	1
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	1	1
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	1	1
SET domain	HIT/MYND zinc finger-like	1	1
Zinc beta-ribbon	Zinc beta-ribbon	1	1
YbaK/ProRS associated domain	C-terminal domain of ProRS	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	4Fe-4S ferredoxins	1	1
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	1	1
tRNA-binding arm	Class II aaRS and biotin synthetases	1	1
(Trans)glycosidases	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	1	1
WD40 repeat-like	Cyclophilin-like	1	1
Voltage-gated potassium channels	E set domains	1	1
RNA-binding domain, RBD	Clavaminate synthase-like	1	1
Kelch motif	Metallo-dependent phosphatases	1	1
Creatinase/aminopeptidase	PH domain-like	1	1
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	1	1
Taf5 N-terminal domain-like	WD40 repeat-like	1	1
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	1	1
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	1	1
Surp module (SWAP domain)	Surp module (SWAP domain)	1	1
Zinc hairpin stack	RING/U-box	1	1
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
Bromodomain	SET domain	1	1
Dom34/Pelota N-terminal domain-like	L30e-like	1	1
(Trans)glycosidases	Six-hairpin glycosidases	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	1	1
SMAD/FHA domain	SMAD/FHA domain	1	1
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	1	1
(Phosphotyrosine protein) phosphatases II	PUG domain-like	1	1
Class II aaRS ABD-related	C-terminal domain of ProRS	1	1
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Dihydrofolate reductase-like	Thymidylate synthase/dCMP hydroxymethylase	1	1
WD40 repeat-like	Bromodomain	1	1
CYTH-like phosphatases	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	1	1
Cysteine proteinases	Ribonuclease H-like	1	1
PH domain-like	PLC-like phosphodiesterases	1	1
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
Rudiment single hybrid motif	Single hybrid motif	1	1
Ankyrin repeat	TPR-like	1	1
EF-hand	SAICAR synthase-like	1	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	1	1
Chaperone J-domain	CSL zinc finger	1	1
Acid proteases	UBA-like	1	1
Pseudouridine synthase	PUA domain-like	1	1
Trimeric LpxA-like enzymes	ARM repeat	1	1
Thiamin diphosphate-binding fold (THDP-binding)	4Fe-4S ferredoxins	1	1
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Oligoxyloglucan reducing end-specific cellobiohydrolase	1	1
DNase I-like	DNase I-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	1	1
Dcp2 domain-like	Nudix	1	1
Fe-S cluster assembly (FSCA) domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	E set domains	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
Chromo domain-like	Bromodomain	1	1
UBA-like	XPC-binding domain	1	1
SET domain	Ankyrin repeat	1	1
PreATP-grasp domain	ClpP/crotonase	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
LCCL domain	LCCL domain	1	1
SRCR-like	SRCR-like	1	1
RNA-binding domain, RBD	PABC (PABP) domain	1	1
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
PR-1-like	PR-1-like	1	1
Bromodomain	Bromodomain	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
LCCL domain	SRCR-like	1	1
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	1	1
Ankyrin repeat	Bromodomain	1	1
HMA, heavy metal-associated domain	HAD-like	1	1
Mannose 6-phosphate receptor domain	YccV-like	1	1
PH domain-like	Oxysterol-binding protein-like	1	1
Thiamin diphosphate-binding fold (THDP-binding)	Flavoproteins	1	1
Chaperone J-domain	Sec63 N-terminal domain-like	1	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	1	1
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	1	1
PreATP-grasp domain	Single hybrid motif	1	1
PAH2 domain	PAH2 domain	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	HAD-like	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
E set domains	E set domains	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	SRCR-like	1	1
ClpP/crotonase	ClpP/crotonase	1	1
Cyclophilin-like	RNA-binding domain, RBD	1	1
FYVE/PHD zinc finger	ARM repeat	1	1
TK C-terminal domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	1	1
Galactose mutarotase-like	(Trans)glycosidases	1	1
PUG domain-like	Ubiquitin-like	1	1
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	1	1
P-loop containing nucleoside triphosphate hydrolases	RNA-binding domain, RBD	1	1
Ankyrin repeat	Complement control module/SCR domain	1	1
Homeodomain-like	CHY zinc finger-like	1	1
alpha/beta-Hydrolases	Galactose-binding domain-like	1	1
GST C-terminal domain-like	eEF-1beta-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	1	1
FYVE/PHD zinc finger	Bromodomain	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	1	1
Pre-PUA domain	PUA domain-like	1	1
TRAF domain-like	POZ domain	1	1
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1	1
TSP-1 type 1 repeat	Kringle-like	1	1
Growth factor receptor domain	Hairpin loop containing domain-like	1	1
EGF/Laminin	Hairpin loop containing domain-like	1	1
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	1	1
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	1	1
RING/U-box	RNA-binding domain, RBD	1	1
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	1	1
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	1	1
dsRNA-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleic acid-binding proteins	TPR-like	1	1
FYSH domain	beta-beta-alpha zinc fingers	1	1
PLP-dependent transferases	Adenine nucleotide alpha hydrolases-like	1	1
Nucleotidylyl transferase	Nucleotidylyl transferase	1	1
Ribonuclease H-like	Ribonuclease H-like	1	1
TPR-like	RNA-binding domain, RBD	1	1
GST C-terminal domain-like	eEF1-gamma domain	1	1
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	1	1
EF-hand	PLC-like phosphodiesterases	1	1
Chaperone J-domain	Homeodomain-like	1	1
TPR-like	Activator of Hsp90 ATPase, Aha1	1	1
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	1	1
(Trans)glycosidases	(Trans)glycosidases	1	1
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	1	1
Calcium ATPase, transmembrane domain M	Nucleotide cyclase	1	1
ADP-ribosylation	B-box zinc-binding domain	1	1
PriA/YqbF domain	GINS helical bundle-like	1	1
WD40 repeat-like	Quinoprotein alcohol dehydrogenase-like	1	1
MIT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	1	1
LCCL domain	Concanavalin A-like lectins/glucanases	1	1
Ankyrin repeat	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Ubiquitin-like	Cysteine proteinases	1	1
RNA-binding domain, RBD	WW domain	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Riboflavin synthase domain-like	1	1
Thiamin diphosphate-binding fold (THDP-binding)	Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	1	1
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	1	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	1	1
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	1	1
cAMP-binding domain-like	Protein kinase-like (PK-like)	1	1
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	1	1
Retrovirus zinc finger-like domains	RING/U-box	1	1
PUA domain-like	eIF1-like	1	1
Starch-binding domain-like	EF-hand	1	1
Concanavalin A-like lectins/glucanases	Amine oxidase catalytic domain	1	1
PRP4-like	WD40 repeat-like	1	1
alpha/beta knot	Nucleic acid-binding proteins	1	1
RNI-like	RNI-like	1	1
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	1	1
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	1	1
Trimeric LpxA-like enzymes	HAD-like	1	1
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
TK C-terminal domain-like	Riboflavin synthase domain-like	1	1
Thioredoxin-like	FAD-dependent thiol oxidase	1	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	1	1
ARM repeat	RING/U-box	1	1
Sec7 domain	Ypt/Rab-GAP domain of gyp1p	1	1
GST C-terminal domain-like	Nucleic acid-binding proteins	1	1
CHY zinc finger-like	Zinc hairpin stack	1	1
RCC1/BLIP-II	Chromo domain-like	1	1
SMAD/FHA domain	BRCT domain	1	1
4Fe-4S ferredoxins	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
ADC-like	Cdc48 domain 2-like	1	1
Enolase N-terminal domain-like	Enolase C-terminal domain-like	1	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	1	1
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	1	1
Carbamate kinase-like	PUA domain-like	1	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	1	1
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	1	1
P-loop containing nucleoside triphosphate hydrolases	EF-hand	1	1
UBC-like	UBA-like	1	1
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
WD40 repeat-like	Ribonuclease H-like	1	1
ARM repeat	Subdomain of clathrin and coatomer appendage domain	1	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	1	1
4Fe-4S ferredoxins	Flavoproteins	1	1
TK C-terminal domain-like	4Fe-4S ferredoxins	1	1
Single hybrid motif	ClpP/crotonase	1	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	1	1
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	1	1
BRCT domain	post-AAA+ oligomerization domain-like	1	1
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	1	1
TPR-like	Formin homology 2 domain (FH2 domain)	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	LCCL domain	1	1
PH domain-like	EF-hand	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
TK C-terminal domain-like	Flavoproteins	1	1
TK C-terminal domain-like	Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
Thiamin diphosphate-binding fold (THDP-binding)	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
WD40 repeat-like	Nucleoporin domain	1	1
Chaperone J-domain	E set domains	1	1
"Winged helix" DNA-binding domain	Zinc beta-ribbon	1	1
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	1	1
Macro domain-like	Zn-dependent exopeptidases	1	1
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	1	1
Putative isomerase YbhE	WD40 repeat-like	1	1
RING/U-box	Homeodomain-like	1	1
PreATP-grasp domain	Rudiment single hybrid motif	1	1
PX domain	WD40 repeat-like	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
DNA polymerase beta, N-terminal domain-like	Restriction endonuclease-like	1	1
Kelch motif	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	1	1
PH domain-like	BEACH domain	1	1
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	1	1
NTF2-like	RNA-binding domain, RBD	1	1
GMP synthetase C-terminal dimerisation domain	GMP synthetase C-terminal dimerisation domain	1	1
Starch-binding domain-like	Protein kinase-like (PK-like)	1	1
EF-hand	cAMP-binding domain-like	1	1
ALDH-like	Dehydroquinate synthase-like	1	1
Cullin repeat-like	Cullin repeat-like	1	1
Ubiquitin-like	Acid proteases	1	1
vWA-like	Cysteine-rich domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	1	1
RING/U-box	WD40 repeat-like	1	1
Hect, E3 ligase catalytic domain	Hect, E3 ligase catalytic domain	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
t-snare proteins	SNARE fusion complex	1	1
WWE domain	RING/U-box	1	1
Eukaryotic type KH-domain (KH-domain type I)	Retrovirus zinc finger-like domains	1	1
Rudiment single hybrid motif	ClpP/crotonase	1	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	1	1
Ubiquitin-like	XPC-binding domain	1	1
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	1	1
ENTH/VHS domain	ARM repeat	1	1
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	1	1

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