Domain combination pairs in Medicago truncatula

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

1737 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
P-loop containing nucleoside triphosphate hydrolases	L domain-like	873	131
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	470	94
L domain-like	L domain-like	469	109
L domain-like	Protein kinase-like (PK-like)	446	48
Toll/Interleukin receptor TIR domain	P-loop containing nucleoside triphosphate hydrolases	423	73
RNI-like	F-box domain	383	18
Toll/Interleukin receptor TIR domain	L domain-like	361	62
RNI-like	L domain-like	333	107
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	310	65
"Winged helix" DNA-binding domain	L domain-like	253	51
Toll/Interleukin receptor TIR domain	"Winged helix" DNA-binding domain	253	48
RNA-binding domain, RBD	RNA-binding domain, RBD	208	26
alpha-D-mannose-specific plant lectins	Protein kinase-like (PK-like)	201	12
P-loop containing nucleoside triphosphate hydrolases	RNI-like	182	60
Actin-like ATPase domain	Actin-like ATPase domain	145	24
RNI-like	RNI-like	144	53
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	137	13
ABC transporter transmembrane region	ABC transporter transmembrane region	110	9
F-box domain	Galactose oxidase, central domain	105	5
Nucleic acid-binding proteins	Nucleic acid-binding proteins	102	25
RNI-like	Protein kinase-like (PK-like)	101	29
GroES-like	NAD(P)-binding Rossmann-fold domains	96	7
Thioredoxin-like	GST C-terminal domain-like	95	7
TPR-like	TPR-like	95	26
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	93	7
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	92	17
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	92	22
HAD-like	Calcium ATPase, transmembrane domain M	91	17
Calcium ATPase, transduction domain A	HAD-like	88	15
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	81	14
RING/U-box	ARM repeat	74	10
ARM repeat	ARM repeat	73	34
Thiolase-like	Thiolase-like	72	3
Cyclin-like	Cyclin-like	71	8
DNA-binding pseudobarrel domain	DNA-binding pseudobarrel domain	69	13
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	66	9
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	66	9
"Winged helix" DNA-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	66	2
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	65	5
(Trans)glycosidases	Galactose-binding domain-like	63	12
Plant invertase/pectin methylesterase inhibitor	Pectin lyase-like	63	2
RING/U-box	RING/U-box	58	20
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	57	7
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	56	9
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	56	6
Cupredoxins	Cupredoxins	54	5
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	54	6
Periplasmic binding protein-like I	Periplasmic binding protein-like II	54	5
POZ domain	Skp1 dimerisation domain-like	53	4
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	53	4
Terpenoid cyclases/Protein prenyltransferases	Terpenoid synthases	53	5
FAD-linked reductases, C-terminal domain	FAD/NAD(P)-binding domain	50	8
Concanavalin A-like lectins/glucanases	Protein kinase-like (PK-like)	50	9
Toll/Interleukin receptor TIR domain	Toll/Interleukin receptor TIR domain	49	18
(Trans)glycosidases	Glycosyl hydrolase domain	48	11
Barwin-like endoglucanases	PHL pollen allergen	47	1
F-box domain	L domain-like	47	10
Homeodomain-like	Homeodomain-like	46	14
Voltage-gated potassium channels	cAMP-binding domain-like	46	5
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	45	9
CheY-like	Homeodomain-like	45	5
Protein kinase-like (PK-like)	EF-hand	44	2
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	43	11
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	42	6
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	42	6
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	41	5
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	41	8
Ubiquitin-like	Ubiquitin-like	40	10
CCCH zinc finger	CCCH zinc finger	40	17
DNA-binding domain	DNA-binding domain	39	5
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	39	5
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipoxigenase	38	2
Ran binding protein zinc finger-like	RNA-binding domain, RBD	38	3
F-box domain	Kelch motif	38	6
FYVE/PHD zinc finger	FYVE/PHD zinc finger	37	18
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	37	6
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	36	8
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	36	12
Galactose-binding domain-like	Galactose-binding domain-like	36	4
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	36	14
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	35	7
ACT-like	ACT-like	33	12
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	32	6
Terpenoid cyclases/Protein prenyltransferases	Terpenoid cyclases/Protein prenyltransferases	30	6
(Trans)glycosidases	Beta-D-glucan exohydrolase, C-terminal domain	29	2
ENTH/VHS domain	GAT-like domain	29	3
PUA domain-like	SET domain	29	3
DNA-binding pseudobarrel domain	CAD & PB1 domains	28	4
vWA-like	RING/U-box	28	4
RING/U-box	Nucleotide-diphospho-sugar transferases	28	3
WRKY DNA-binding domain	WRKY DNA-binding domain	28	2
Purple acid phosphatase, N-terminal domain	Metallo-dependent phosphatases	27	4
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	27	7
Cullin homology domain	"Winged helix" DNA-binding domain	27	4
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	27	3
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	26	7
Surp module (SWAP domain)	Surp module (SWAP domain)	26	3
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	26	15
ACT-like	Protein kinase-like (PK-like)	26	2
FYVE/PHD zinc finger	Acyl-CoA N-acyltransferases (Nat)	25	8
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	25	10
Phospholipase D/nuclease	Phospholipase D/nuclease	25	9
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	SAICAR synthase-like	24	6
E set domains	P-loop containing nucleoside triphosphate hydrolases	24	4
PAH2 domain	PAH2 domain	24	7
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	24	5
GroEL equatorial domain-like	GroEL apical domain-like	24	6
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	23	4
Adenine nucleotide alpha hydrolases-like	Protein kinase-like (PK-like)	23	4
Homeodomain-like	Bet v1-like	23	6
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	23	8
Clc chloride channel	CBS-domain pair	23	4
Bacterial exopeptidase dimerisation domain	Zn-dependent exopeptidases	23	4
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	23	4
Ankyrin repeat	Ankyrin repeat	22	5
GroEL equatorial domain-like	GroEL-intermediate domain like	22	5
CBS-domain pair	CBS-domain pair	22	8
EF-hand	Riboflavin synthase domain-like	22	2
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	22	10
Thioredoxin-like	Thioredoxin-like	22	12
PAZ domain	Ribonuclease H-like	22	4
GroEL-intermediate domain like	GroEL apical domain-like	22	5
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	22	7
Ribonuclease H-like	DNA/RNA polymerases	22	4
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	22	5
GroES-like	GroES-like	22	2
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	22	5
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	21	6
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	21	9
Subtilisin-like	PA domain	21	4
Amine oxidase N-terminal region	Amine oxidase catalytic domain	21	3
FKBP-like	FKBP-like	21	8
dsRNA-binding domain-like	dsRNA-binding domain-like	21	9
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	21	5
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	21	8
E set domains	Ankyrin repeat	21	2
Ankyrin repeat	P-loop containing nucleoside triphosphate hydrolases	21	4
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	20	8
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheY-like	20	6
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	20	1
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	20	7
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	20	3
SNARE-like	SNARE fusion complex	20	2
EF-G C-terminal domain-like	EF-G C-terminal domain-like	20	7
Amine oxidase N-terminal region	Amine oxidase N-terminal region	20	3
Bet v1-like	Bet v1-like	20	6
ARM repeat	Protein kinase-like (PK-like)	20	17
Translation proteins	EF-G C-terminal domain-like	20	7
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	20	1
EF-hand	P-loop containing nucleoside triphosphate hydrolases	20	5
Double Clp-N motif	P-loop containing nucleoside triphosphate hydrolases	20	8
Homodimeric domain of signal transducing histidine kinase	CheY-like	20	6
Homeodomain-like	"Winged helix" DNA-binding domain	20	2
Cullin repeat-like	Cullin homology domain	19	4
WD40 repeat-like	WD40 repeat-like	19	11
FKBP-like	TPR-like	19	4
Zinc hairpin stack	RING/U-box	19	5
Chromo domain-like	Chromo domain-like	18	3
Protein kinase-like (PK-like)	RING/U-box	18	6
CHY zinc finger-like	Zinc hairpin stack	18	4
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	18	13
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	18	3
TRAF domain-like	Ubiquitin-like	18	2
FYVE/PHD zinc finger	RING/U-box	18	9
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	18	3
CHY zinc finger-like	RING/U-box	18	4
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	18	11
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	18	7
C2 domain (Calcium/lipid-binding domain, CaLB)	Phospholipase D/nuclease	17	4
ARM repeat	Hect, E3 ligase catalytic domain	17	4
PK beta-barrel domain-like	PK C-terminal domain-like	17	2
EF-hand	Ferredoxin reductase-like, C-terminal NADP-linked domain	17	1
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	17	2
F-box domain	Tubby C-terminal domain-like	17	3
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	17	5
Acid proteases	Saposin	17	1
RING/U-box	P-loop containing nucleoside triphosphate hydrolases	17	5
Metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	17	6
EGF/Laminin	Protein kinase-like (PK-like)	17	5
FYVE/PHD zinc finger	SET domain	17	10
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	17	11
TPR-like	HCP-like	16	12
Cullin repeat-like	"Winged helix" DNA-binding domain	16	2
YhbY-like	YhbY-like	16	6
TATA-box binding protein-like	TATA-box binding protein-like	16	2
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	16	5
Starch-binding domain-like	Galactose-binding domain-like	16	3
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	16	9
FAS1 domain	FAS1 domain	16	3
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	16	4
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	15	2
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	15	3
Arabinanase/levansucrase/invertase	Concanavalin A-like lectins/glucanases	15	2
Protein kinase-like (PK-like)	WD40 repeat-like	15	4
UDP-Glycosyltransferase/glycogen phosphorylase	HAD-like	15	3
Translation proteins	Ribosomal protein S5 domain 2-like	15	4
Protein kinase-like (PK-like)	TPR-like	15	3
Galactose mutarotase-like	(Trans)glycosidases	15	3
P-loop containing nucleoside triphosphate hydrolases	dsRNA-binding domain-like	15	5
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	15	3
RING/U-box	Ankyrin repeat	15	5
EF-hand	EF-hand	15	7
Translation proteins SH3-like domain	Nucleic acid-binding proteins	15	4
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	15	9
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	14	7
PA domain	Zn-dependent exopeptidases	14	3
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	14	3
Homeodomain-like	FAD-linked reductases, C-terminal domain	14	2
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	14	10
HCP-like	HCP-like	14	7
NTF2-like	RNA-binding domain, RBD	14	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	14	6
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	14	9
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	14	4
Galactose mutarotase-like	Glycosyl hydrolase domain	14	2
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	14	6
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	14	2
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	14	7
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	14	2
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	14	3
Homeodomain-like	FAD/NAD(P)-binding domain	14	2
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	14	10
F-box domain	F-box domain	13	7
RING/U-box	TRAF domain-like	13	3
PGBD-like	Metalloproteases ("zincins"), catalytic domain	13	2
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	13	5
(Trans)glycosidases	Ricin B-like lectins	13	3
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	13	2
Calponin-homology domain, CH-domain	P-loop containing nucleoside triphosphate hydrolases	13	2
ARM repeat	WD40 repeat-like	13	10
Carbamate kinase-like	ACT-like	13	4
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	13	3
UBA-like	Ubiquitin-like	13	6
Toll/Interleukin receptor TIR domain	RNI-like	13	9
Protease propeptides/inhibitors	Subtilisin-like	13	3
E set domains	(Trans)glycosidases	13	6
Tropomyosin	Tropomyosin	13	4
EF-hand	PLC-like phosphodiesterases	12	3
PYP-like sensor domain (PAS domain)	Protein kinase-like (PK-like)	12	3
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	12	7
ClpP/crotonase	ClpP/crotonase	12	5
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	12	4
Trypsin-like serine proteases	PDZ domain-like	12	5
Protein kinase-like (PK-like)	Ankyrin repeat	12	3
HMA, heavy metal-associated domain	HAD-like	12	9
POZ domain	Ankyrin repeat	12	4
MFS general substrate transporter	MFS general substrate transporter	12	2
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	12	2
BAR/IMD domain-like	SH3-domain	11	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	11	5
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	11	1
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	11	4
GAF domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	11	4
C2 domain (Calcium/lipid-binding domain, CaLB)	EF-hand	11	2
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	11	5
Quinoprotein alcohol dehydrogenase-like	WD40 repeat-like	11	10
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	11	4
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	11	1
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	11	3
Flavoproteins	Riboflavin synthase domain-like	11	3
E set domains	Glycosyl hydrolase domain	11	5
RNase III domain-like	dsRNA-binding domain-like	11	6
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	11	5
Class II aaRS and biotin synthetases	GAD domain-like	11	3
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	11	2
HAD-like	BRCT domain	11	3
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	11	1
PH domain-like	Oxysterol-binding protein-like	10	1
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	10	5
TPR-like	Chaperone J-domain	10	4
t-snare proteins	SNARE fusion complex	10	3
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	10	5
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	10	2
RCC1/BLIP-II	RCC1/BLIP-II	10	4
Zn-finger domain of Sec23/24	vWA-like	10	4
POZ domain	TRAF domain-like	10	2
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	10	5
WD40 repeat-like	RING/U-box	10	6
Galactose-binding domain-like	Galactose mutarotase-like	10	3
Tudor/PWWP/MBT	FYVE/PHD zinc finger	10	5
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	10	3
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	10	4
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	10	4
Homeodomain-like	RING/U-box	10	3
beta-sandwich domain of Sec23/24	Zn-finger domain of Sec23/24	10	4
BRCT domain	BRCT domain	10	8
vWA-like	Helical domain of Sec23/24	10	4
ARM repeat	Sec7 domain	10	5
beta-sandwich domain of Sec23/24	vWA-like	10	4
Sec63 N-terminal domain-like	E set domains	10	4
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	10	4
Tudor/PWWP/MBT	SET domain	9	4
RING/U-box	Cysteine proteinases	9	5
UBA-like	UBA-like	9	7
HD-domain/PDEase-like	Nucleotidyltransferase	9	6
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	9	3
"Winged helix" DNA-binding domain	RNI-like	9	6
CCCH zinc finger	RNA-binding domain, RBD	9	4
Sigma3 and sigma4 domains of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	9	3
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	9	3
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	9	1
Homeodomain-like	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	9	2
RmlC-like cupins	RmlC-like cupins	9	2
RuBisCO, large subunit, small (N-terminal) domain	RuBisCo, C-terminal domain	9	2
Sigma2 domain of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	9	3
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	9	4
Cysteine proteinases	UBA-like	9	3
Chromo domain-like	S-adenosyl-L-methionine-dependent methyltransferases	9	1
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	9	4
Nucleotidylyl transferase	ValRS/IleRS/LeuRS editing domain	9	5
ISP domain	Bet v1-like	9	3
E set domains	CBS-domain pair	9	2
PreATP-grasp domain	Rudiment single hybrid motif	9	5
RNase III domain-like	RNase III domain-like	9	6
ARM repeat	POZ domain	9	4
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	9	7
WW domain	WW domain	9	5
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	9	5
Galactose oxidase, central domain	E set domains	9	2
ARID-like	FYVE/PHD zinc finger	9	3
(Phosphotyrosine protein) phosphatases II	Formin homology 2 domain (FH2 domain)	9	2
C2 domain (Calcium/lipid-binding domain, CaLB)	Formin homology 2 domain (FH2 domain)	9	2
P-loop containing nucleoside triphosphate hydrolases	ARM repeat	9	5
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	9	3
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	9	3
Galactose mutarotase-like	Starch-binding domain-like	9	2
Single hybrid motif	CoA-dependent acyltransferases	8	4
CAD & PB1 domains	Protein kinase-like (PK-like)	8	1
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	8	4
L domain-like	Formin homology 2 domain (FH2 domain)	8	2
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	8	4
(Trans)glycosidases	Chitinase insertion domain	8	4
POZ domain	POZ domain	8	6
Zinc beta-ribbon	Cyclin-like	8	2
DNA-binding pseudobarrel domain	P-loop containing nucleoside triphosphate hydrolases	8	6
FAD/NAD(P)-binding domain	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	8	1
DUSP-like	Cysteine proteinases	8	3
Protein kinase-like (PK-like)	Formin homology 2 domain (FH2 domain)	8	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	8	3
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	8	1
SET domain	RuBisCo LSMT C-terminal, substrate-binding domain	8	3
Nucleotidylyl transferase	Nucleotidylyl transferase	8	1
HIT/MYND zinc finger-like	Cysteine proteinases	8	1
E set domains	AMPKBI-like	8	2
Actin-crosslinking proteins	(Trans)glycosidases	8	1
Adenine nucleotide alpha hydrolases-like	RING/U-box	8	1
Cysteine proteinases	Granulin repeat	8	2
P-loop containing nucleoside triphosphate hydrolases	CYTH-like phosphatases	8	3
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	8	2
CheY-like	CheY-like	8	1
LysM domain	Protein kinase-like (PK-like)	8	2
FAD-linked reductases, C-terminal domain	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	8	1
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	8	3
ACT-like	NAD(P)-binding Rossmann-fold domains	8	4
Actin depolymerizing proteins	Actin depolymerizing proteins	8	4
ADC-like	Cdc48 domain 2-like	8	4
Nucleic acid-binding proteins	GAD domain-like	8	2
EF-hand	Voltage-gated potassium channels	8	3
Translation proteins	Initiation factor IF2/eIF5b, domain 3	8	4
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	8	4
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	7	4
L domain-like	Actin-like ATPase domain	7	6
Thioredoxin-like	TPR-like	7	4
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	7	2
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	7	3
Class II aaRS ABD-related	C-terminal domain of ProRS	7	2
PDZ domain-like	ClpP/crotonase	7	1
Carbamate kinase-like	ALDH-like	7	1
RCC1/BLIP-II	FYVE/PHD zinc finger	7	2
Dihydrofolate reductase-like	Thymidylate synthase/dCMP hydroxymethylase	7	1
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	7	2
ArfGap/RecO-like zinc finger	C2 domain (Calcium/lipid-binding domain, CaLB)	7	3
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	7	2
PH domain-like	FYVE/PHD zinc finger	7	2
TPR-like	CAD & PB1 domains	7	2
EF-hand	Mitochondrial carrier	7	2
"Winged helix" DNA-binding domain	E set domains	7	3
PurM N-terminal domain-like	PurM C-terminal domain-like	7	4
PAZ domain	RNase III domain-like	7	5
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	7	4
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	7	4
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	7	2
ENT-like	Tudor/PWWP/MBT	7	2
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	7	3
F-box domain	HCP-like	7	3
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	7	1
PH domain-like	P-loop containing nucleoside triphosphate hydrolases	7	3
PH domain-like	Bet v1-like	7	2
ARID-like	HMG-box	7	4
RCC1/BLIP-II	Protein kinase-like (PK-like)	7	4
POZ domain	TAZ domain	7	2
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	7	2
RING/U-box	TAZ domain	7	3
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	7	3
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	7	2
P-loop containing nucleoside triphosphate hydrolases	RNase III domain-like	7	5
TRAF domain-like	Cysteine proteinases	7	2
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	7	2
GAF domain-like	Homodimeric domain of signal transducing histidine kinase	7	4
Ubiquitin-like	BAG domain	7	3
DNase I-like	EF-hand	7	4
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	7	2
Enolase N-terminal domain-like	Enolase C-terminal domain-like	7	3
RNA-binding domain, RBD	PABC (PABP) domain	7	3
Nucleoside hydrolase	Nucleoside hydrolase	7	3
Aconitase iron-sulfur domain	LeuD/IlvD-like	7	4
Periplasmic binding protein-like II	ACT-like	7	1
P-loop containing nucleoside triphosphate hydrolases	UBA-like	7	5
"Winged helix" DNA-binding domain	Actin-like ATPase domain	7	6
P-loop containing nucleoside triphosphate hydrolases	PAZ domain	7	5
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	7	4
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	7	3
P-loop containing nucleoside triphosphate hydrolases	Actin-like ATPase domain	7	6
(Phosphotyrosine protein) phosphatases II	DNA ligase/mRNA capping enzyme, catalytic domain	7	4
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	7	2
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	7	1
RING/U-box	RNA-binding domain, RBD	7	1
Surp module (SWAP domain)	Ubiquitin-like	7	1
Voltage-gated potassium channels	TrkA C-terminal domain-like	7	1
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	7	2
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	7	2
FYVE/PHD zinc finger	TAZ domain	7	3
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	7	2
NAD(P)-binding Rossmann-fold domains	Galactose-binding domain-like	7	2
GST C-terminal domain-like	eEF-1beta-like	6	3
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	6	2
Carbamate kinase-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	6	2
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	6	2
FYVE/PHD zinc finger	Homeodomain-like	6	2
Translational machinery components	L30e-like	6	3
MOSC N-terminal domain-like	PK beta-barrel domain-like	6	1
GINS helical bundle-like	PriA/YqbF domain	6	2
Retrovirus zinc finger-like domains	RING/U-box	6	1
PH domain-like	ArfGap/RecO-like zinc finger	6	4
(Trans)glycosidases	(Trans)glycosidases	6	3
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	6	3
Tetrahydrobiopterin biosynthesis enzymes-like	Tetrahydrobiopterin biosynthesis enzymes-like	6	2
Ubiquitin-like	Zn-binding ribosomal proteins	6	1
Toll/Interleukin receptor TIR domain	Actin-like ATPase domain	6	5
ARM repeat	Clathrin adaptor appendage domain	6	4
PH domain-like	RCC1/BLIP-II	6	1
SAP domain	FYVE/PHD zinc finger	6	2
Carbamate kinase-like	NAD(P)-binding Rossmann-fold domains	6	2
Plant lectins/antimicrobial peptides	Lysozyme-like	6	2
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	6	1
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	6	3
C2 domain (Calcium/lipid-binding domain, CaLB)	vWA-like	6	2
Actin depolymerizing proteins	VHP, Villin headpiece domain	6	2
FYVE/PHD zinc finger	Plus3-like	6	3
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	6	3
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	6	2
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	6	1
Oxidoreductase molybdopterin-binding domain	E set domains	6	3
Cysteine proteinases	Sec-C motif	6	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	6	4
POZ domain	TPR-like	6	4
Thioredoxin-like	Cysteine-rich domain	6	2
RING/U-box	PUA domain-like	6	3
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	6	3
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	6	4
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	6	4
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	6	2
GroEL apical domain-like	SAICAR synthase-like	6	3
TPR-like	RING/U-box	6	3
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	6	1
ACT-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	6	2
Ubiquitin-like	Protein kinase-like (PK-like)	6	1
SWIB/MDM2 domain	Plus3-like	6	3
ADC-like	P-loop containing nucleoside triphosphate hydrolases	6	2
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	6	2
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	6	2
(Phosphotyrosine protein) phosphatases II	Nucleic acid-binding proteins	6	3
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	6	4
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	6	1
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	6	3
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	6	2
FAD/NAD(P)-binding domain	EF-hand	6	2
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	6	2
Cap-Gly domain	Ubiquitin-like	6	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	6	2
ACT-like	Formyltransferase	6	1
BAR/IMD domain-like	PH domain-like	6	4
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	6	1
Voltage-gated potassium channels	Voltage-gated potassium channels	6	3
LEA14-like	LEA14-like	6	2
(Trans)glycosidases	Protein kinase-like (PK-like)	6	3
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	6	4
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	6	1
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	6	1
Trypsin-like serine proteases	Trypsin-like serine proteases	6	5
SMAD/FHA domain	P-loop containing nucleoside triphosphate hydrolases	6	1
CBS-domain pair	CAD & PB1 domains	6	2
Ribonuclease H-like	HRDC-like	6	2
Translation proteins	ThrRS/AlaRS common domain	6	2
Metallo-hydrolase/oxidoreductase	DNA ligase/mRNA capping enzyme, catalytic domain	5	3
Protein kinase-like (PK-like)	KA1-like	5	1
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	5	2
UROD/MetE-like	UROD/MetE-like	5	2
ArfGap/RecO-like zinc finger	Ankyrin repeat	5	3
UBC-like	UBA-like	5	1
SMAD/FHA domain	PP2C-like	5	1
Ubiquitin-like	Homeodomain-like	5	1
CCCH zinc finger	RING/U-box	5	2
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	5	3
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	5	2
GST C-terminal domain-like	eEF1-gamma domain	5	1
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	5	4
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	5	1
TPR-like	"Winged helix" DNA-binding domain	5	2
Tropomyosin	P-loop containing nucleoside triphosphate hydrolases	5	4
PAZ domain	dsRNA-binding domain-like	5	3
BAR/IMD domain-like	Ankyrin repeat	5	3
TRAF domain-like	TRAF domain-like	5	4
HCP-like	HIT/MYND zinc finger-like	5	2
BEACH domain	WD40 repeat-like	5	4
Metallo-hydrolase/oxidoreductase	ATP-dependent DNA ligase DNA-binding domain	5	3
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	5	2
PH domain-like	Ankyrin repeat	5	3
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	5	1
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	5	4
P-loop containing nucleoside triphosphate hydrolases	Protein kinase-like (PK-like)	5	5
C-terminal domain of alpha and beta subunits of F1 ATP synthase	Epsilon subunit of F1F0-ATP synthase N-terminal domain	5	2
TPR-like	SET domain	5	2
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	5	2
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	5	2
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	5	2
PYP-like sensor domain (PAS domain)	GAF domain-like	5	1
P-loop containing nucleoside triphosphate hydrolases	Epsilon subunit of F1F0-ATP synthase N-terminal domain	5	2
cAMP-binding domain-like	Ankyrin repeat	5	1
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	5	3
SWIB/MDM2 domain	SWIB/MDM2 domain	5	2
GAF domain-like	GAF domain-like	5	1
RING/U-box	UBA-like	5	2
Metallo-dependent hydrolases	Glutamine synthetase, N-terminal domain	5	1
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	5	2
F-box domain	Actin-like ATPase domain	5	1
YjgF-like	YjgF-like	5	1
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	5	2
ARM repeat	Tudor/PWWP/MBT	5	4
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	5	2
Class I glutamine amidotransferase-like	Class I glutamine amidotransferase-like	5	2
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	5	3
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	5	2
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	5	1
Adenine nucleotide alpha hydrolases-like	YjgF-like	5	1
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	5	1
P-loop containing nucleoside triphosphate hydrolases	Macro domain-like	5	3
alpha-D-mannose-specific plant lectins	alpha-D-mannose-specific plant lectins	5	3
Ribulose-phoshate binding barrel	Ribulose-phoshate binding barrel	5	2
FYVE/PHD zinc finger	SWIB/MDM2 domain	5	2
Chaperone J-domain	4Fe-4S ferredoxins	5	3
GAF domain-like	CheY-like	5	3
PLC-like phosphodiesterases	PLC-like phosphodiesterases	5	3
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	5	2
PWI domain	RNA-binding domain, RBD	5	2
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	5	1
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	5	3
Voltage-gated potassium channels	Ankyrin repeat	5	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	5	1
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	5	4
Ricin B-like lectins	Glycosyl hydrolase domain	5	1
Kelch motif	Kelch motif	5	3
Metallo-dependent hydrolases	Glutamine synthetase/guanido kinase	5	1
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	5	3
CCCH zinc finger	Eukaryotic type KH-domain (KH-domain type I)	5	3
Class II aaRS and biotin synthetases	Translation proteins	5	1
Thioredoxin-like	eEF1-gamma domain	5	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	4	2
Cyclophilin-like	TPR-like	4	1
SBT domain	Ankyrin repeat	4	2
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	4	2
PurM N-terminal domain-like	Class I glutamine amidotransferase-like	4	2
NAD(P)-binding Rossmann-fold domains	Glutamyl tRNA-reductase dimerization domain	4	2
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	4	1
UBA-like	Hect, E3 ligase catalytic domain	4	2
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	4	3
FYVE/PHD zinc finger	Transducin (alpha subunit), insertion domain	4	2
WD40 repeat-like	F-box domain	4	3
Quinoprotein alcohol dehydrogenase-like	3-carboxy-cis,cis-mucoante lactonizing enzyme	4	3
PLP-binding barrel	Alanine racemase C-terminal domain-like	4	2
ARM repeat	TPR-like	4	3
PA domain	Transferrin receptor-like dimerisation domain	4	1
SNARE fusion complex	SNARE fusion complex	4	2
PH domain-like	BEACH domain	4	3
FYVE/PHD zinc finger	Clavaminate synthase-like	4	2
tRNA-binding arm	Class II aaRS and biotin synthetases	4	2
PP2C-like	Protein kinase-like (PK-like)	4	4
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	4	2
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	4	2
Formate/glycerate dehydrogenase catalytic domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	4	1
alpha-D-mannose-specific plant lectins	Hairpin loop containing domain-like	4	2
Arp2/3 complex subunits	Arp2/3 complex subunits	4	1
PurM C-terminal domain-like	Class I glutamine amidotransferase-like	4	2
ClpP/crotonase	6-phosphogluconate dehydrogenase C-terminal domain-like	4	2
Ubiquitin-like	Cysteine proteinases	4	2
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	4	1
TPR-like	HSP20-like chaperones	4	2
ARM repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	4	4
Thioredoxin-like	"Winged helix" DNA-binding domain	4	1
alpha/beta-Hydrolases	alpha/beta-Hydrolases	4	3
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	4	3
FYVE/PHD zinc finger	GroEL apical domain-like	4	2
Chitinase insertion domain	Protein kinase-like (PK-like)	4	2
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	4	1
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	4	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	Epsilon subunit of F1F0-ATP synthase N-terminal domain	4	1
FYVE/PHD zinc finger	GYF domain	4	2
F-box domain	P-loop containing nucleoside triphosphate hydrolases	4	4
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	4	2
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	4	3
Ubiquitin-like	Hect, E3 ligase catalytic domain	4	2
Glutamyl tRNA-reductase catalytic, N-terminal domain	NAD(P)-binding Rossmann-fold domains	4	2
CCCH zinc finger	HIT-like	4	1
Hemopexin-like domain	Hemopexin-like domain	4	1
FF domain	FF domain	4	3
ARM repeat	Subdomain of clathrin and coatomer appendage domain	4	3
P-loop containing nucleoside triphosphate hydrolases	RNA-binding domain, RBD	4	4
PH domain-like	GTPase activation domain, GAP	4	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	4	2
Putative DNA-binding domain	Putative DNA-binding domain	4	2
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	4	2
P-loop containing nucleoside triphosphate hydrolases	Pre-protein crosslinking domain of SecA	4	4
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	4	1
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	4	3
PRTase-like	Ribulose-phoshate binding barrel	4	1
Zn-dependent exopeptidases	Transferrin receptor-like dimerisation domain	4	1
Clathrin heavy-chain terminal domain	ARM repeat	4	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	4	3
F-box domain	HIT/MYND zinc finger-like	4	1
YrdC/RibB	RibA-like	4	2
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	4	2
E set domains	RNA-binding domain, RBD	4	1
Starch-binding domain-like	Phosphoglycerate mutase-like	4	1
Hairpin loop containing domain-like	Protein kinase-like (PK-like)	4	2
(Phosphotyrosine protein) phosphatases II	NAD kinase/diacylglycerol kinase-like	4	1
Ubiquitin-like	PUG domain-like	4	3
ARM repeat	UBA-like	4	2
PRTase-like	PRTase-like	4	2
E set domains	E set domains	4	2
BRCT domain	FYVE/PHD zinc finger	4	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	4	1
BRCT domain	RING/U-box	4	2
PH domain-like	WD40 repeat-like	4	3
Putative isomerase YbhE	WD40 repeat-like	4	3
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	4	2
Protein kinase-like (PK-like)	PH domain-like	4	2
vWA-like	Cysteine-rich domain	4	1
WW domain	P-loop containing nucleoside triphosphate hydrolases	4	1
Globin-like	Globin-like	4	1
Starch-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	4	1
PH domain-like	ARM repeat	4	3
FYVE/PHD zinc finger	SAICAR synthase-like	4	2
FYVE/PHD zinc finger	Ankyrin repeat	4	1
P-loop containing nucleoside triphosphate hydrolases	TGS-like	4	2
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	4	2
MIT domain	P-loop containing nucleoside triphosphate hydrolases	4	1
Hypothetical protein SAV1430	Fe-S cluster assembly (FSCA) domain-like	4	1
Kelch motif	Metallo-dependent phosphatases	4	2
PH domain-like	Phospholipase D/nuclease	4	2
USP8 N-terminal domain-like	JAB1/MPN domain	4	2
WW domain	FF domain	4	3
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	4	3
Glutamyl tRNA-reductase catalytic, N-terminal domain	Glutamyl tRNA-reductase dimerization domain	4	2
ARID-like	Clavaminate synthase-like	4	2
Chaperone J-domain	CSL zinc finger	4	2
WD40 repeat-like	DNase I-like	4	2
Ribonuclease H-like	Ribonuclease H-like	3	2
Oxidoreductase molybdopterin-binding domain	Cytochrome b5-like heme/steroid binding domain	3	2
Nucleic acid-binding proteins	eIF2alpha middle domain-like	3	1
Folate-binding domain	Aminomethyltransferase beta-barrel domain	3	2
Second domain of FERM	P-loop containing nucleoside triphosphate hydrolases	3	2
Ribonuclease PH domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	3	2
(Phosphotyrosine protein) phosphatases II	Actin depolymerizing proteins	3	2
HAD-like	Thioredoxin-like	3	1
L domain-like	UDP-Glycosyltransferase/glycogen phosphorylase	3	3
Chaperone J-domain	Thioredoxin-like	3	2
SufE/NifU	BolA-like	3	1
Actin-crosslinking proteins	Actin-crosslinking proteins	3	1
PurS-like	PurM C-terminal domain-like	3	1
Ribosomal protein L6	Ribosomal protein L6	3	1
Histone-fold	ARM repeat	3	2
Dom34/Pelota N-terminal domain-like	L30e-like	3	1
Cytochrome b5-like heme/steroid binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
Class II aaRS and biotin synthetases	HD-domain/PDEase-like	3	3
BRCT domain	Lesion bypass DNA polymerase (Y-family), little finger domain	3	1
Osmotin, thaumatin-like protein	Protein kinase-like (PK-like)	3	2
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	3	2
HAD-like	Riboflavin kinase-like	3	1
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	3	2
Ubiquitin-like	TPR-like	3	1
UBA-like	XPC-binding domain	3	2
E set domains	Cytochrome b5-like heme/steroid binding domain	3	2
Ribosomal protein S5 domain 2-like	Nucleic acid-binding proteins	3	2
TPR-like	PUA domain-like	3	1
RNA-binding domain, RBD	DNase I-like	3	2
E set domains	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
HAD-like	NHL repeat	3	1
Ribosomal L27 protein-like	Nucleic acid-binding proteins	3	2
Undecaprenyl diphosphate synthase	Undecaprenyl diphosphate synthase	3	1
Phage tail proteins	Phage tail proteins	3	3
Chaperone J-domain	RNA-binding domain, RBD	3	2
PurM N-terminal domain-like	PurM N-terminal domain-like	3	1
LysM domain	LysM domain	3	1
HLH, helix-loop-helix DNA-binding domain	ACT-like	3	2
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	3	1
Quinoprotein alcohol dehydrogenase-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	3	3
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	3	2
PH domain-like	HMG-box	3	1
PUA domain-like	Ribosomal protein S5 domain 2-like	3	2
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	3	1
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	3	2
Cation efflux protein cytoplasmic domain-like	Cation efflux protein cytoplasmic domain-like	3	2
"Winged helix" DNA-binding domain	Elongation factor Ts (EF-Ts), dimerisation domain	3	3
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	3	3
P-loop containing nucleoside triphosphate hydrolases	RecA protein, C-terminal domain	3	2
Ubiquitin-like	XPC-binding domain	3	2
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	3	2
Translational machinery components	RBP11-like subunits of RNA polymerase	3	2
FGAM synthase PurL, linker domain	PurM C-terminal domain-like	3	1
Saposin	Saposin	3	2
BRCA2 helical domain	Nucleic acid-binding proteins	3	3
PreATP-grasp domain	Single hybrid motif	3	3
Flavoproteins	Protein kinase-like (PK-like)	3	1
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	3	2
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	3	3
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	3	3
PurS-like	Class I glutamine amidotransferase-like	3	1
Nucleotidylyl transferase	Ribosomal protein L25-like	3	2
FGAM synthase PurL, linker domain	PurM N-terminal domain-like	3	1
Putative DNA-binding domain	PheT/TilS domain	3	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	3	2
BRCA2 helical domain	BRCA2 tower domain	3	3
Tricorn protease N-terminal domain	DPP6 N-terminal domain-like	3	1
BRCT domain	DNA/RNA polymerases	3	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	3	1
POZ domain	RNI-like	3	2
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	3	2
Ribosomal protein S5 domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	3	2
Cullin repeat-like	Cullin repeat-like	3	3
Chaperone J-domain	Sec63 N-terminal domain-like	3	1
Thioredoxin-like	NHL repeat	3	1
beta and beta-prime subunits of DNA dependent RNA-polymerase	beta and beta-prime subunits of DNA dependent RNA-polymerase	3	2
HIT-like	HIT-like	3	2
MoeA N-terminal region -like	MoeA C-terminal domain-like	3	3
MoeA N-terminal region -like	Molybdenum cofactor biosynthesis proteins	3	3
Chaperone J-domain	E set domains	3	1
Osmotin, thaumatin-like protein	alpha-D-mannose-specific plant lectins	3	2
Cytochrome b5-like heme/steroid binding domain	Riboflavin synthase domain-like	3	2
Fe-S cluster assembly (FSCA) domain-like	Fe-S cluster assembly (FSCA) domain-like	3	1
HMA, heavy metal-associated domain	"Winged helix" DNA-binding domain	3	2
DNA-binding domain	DNA-binding pseudobarrel domain	3	3
PapD-like	Ankyrin repeat	3	3
Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	3	2
Clavaminate synthase-like	Clavaminate synthase-like	3	1
Translation proteins	Translation proteins	3	1
P-loop containing nucleoside triphosphate hydrolases	UDP-Glycosyltransferase/glycogen phosphorylase	3	3
RNI-like	ARM repeat	3	1
PRP4-like	WD40 repeat-like	3	2
Translational machinery components	Insert subdomain of RNA polymerase alpha subunit	3	2
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Nucleic acid-binding proteins	3	2
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	3	1
PreATP-grasp domain	PreATP-grasp domain	3	3
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	3	2
Tudor/PWWP/MBT	RNA-binding domain, RBD	3	1
Cytidine deaminase-like	Dihydrofolate reductase-like	3	2
P-loop containing nucleoside triphosphate hydrolases	vWA-like	3	2
P-loop containing nucleoside triphosphate hydrolases	Helical scaffold and wing domains of SecA	3	3
Outer arm dynein light chain 1	L domain-like	3	3
E set domains	Riboflavin synthase domain-like	3	2
Cytochrome f, large domain	Rudiment single hybrid motif	3	2
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	3	1
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	3	2
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	3	1
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	3	3
Protein kinase-like (PK-like)	(Phosphotyrosine protein) phosphatases II	3	1
Eukaryotic type KH-domain (KH-domain type I)	LigT-like	3	2
DNase I-like	DNase I-like	3	2
PurS-like	FGAM synthase PurL, linker domain	3	1
HAD-like	Glycerol-3-phosphate (1)-acyltransferase	3	1
P-loop containing nucleoside triphosphate hydrolases	Elongation factor Ts (EF-Ts), dimerisation domain	3	3
Second domain of FERM	PH domain-like	3	2
PAH2 domain	F-box domain	3	1
Tropomyosin	Apolipoprotein A-I	3	1
PUA domain-like	P-loop containing nucleoside triphosphate hydrolases	3	2
Thioredoxin-like	Ubiquitin-like	3	1
HAD-like	NTF2-like	3	1
GroEL-intermediate domain like	GroEL-intermediate domain like	3	2
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	3	2
PUA domain-like	alpha/beta knot	3	1
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	3	1
Rudiment single hybrid motif	Single hybrid motif	3	3
WWE domain	ADP-ribosylation	3	2
PheT/TilS domain	Class II aaRS and biotin synthetases	3	1
Toll/Interleukin receptor TIR domain	UDP-Glycosyltransferase/glycogen phosphorylase	3	3
PLP-dependent transferases	Ornithine decarboxylase C-terminal domain	3	1
Bacterial photosystem II reaction centre, L and M subunits	Photosystem II antenna protein-like	3	1
F-box domain	Protein kinase-like (PK-like)	3	2
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	3	1
Pre-protein crosslinking domain of SecA	Helical scaffold and wing domains of SecA	3	3
Metallo-hydrolase/oxidoreductase	Nucleic acid-binding proteins	3	1
Concanavalin A-like lectins/glucanases	WD40 repeat-like	3	2
Cyclophilin-like	RNA-binding domain, RBD	3	1
Scorpion toxin-like	Scorpion toxin-like	3	2
L domain-like	Elongation factor Ts (EF-Ts), dimerisation domain	3	3
PurM C-terminal domain-like	PurM C-terminal domain-like	3	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	3	2
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	3	2
Cystatin/monellin	Cystatin/monellin	3	3
Heat shock protein 70kD (HSP70), C-terminal subdomain	Heat shock protein 70kD (HSP70), C-terminal subdomain	3	1
WGR domain-like	Domain of poly(ADP-ribose) polymerase	3	3
Metalloproteases ("zincins"), catalytic domain	HAD-like	3	1
Ribosomal proteins S24e, L23 and L15e	Nucleic acid-binding proteins	3	2
DUSP-like	Ubiquitin-like	3	1
Concanavalin A-like lectins/glucanases	BEACH domain	3	2
Alpha-L RNA-binding motif	Pseudouridine synthase	3	1
Nucleic acid-binding proteins	BRCA2 tower domain	3	3
HisI-like	all-alpha NTP pyrophosphatases	3	2
Macro domain-like	CRAL/TRIO domain	3	1
FGAM synthase PurL, linker domain	Class I glutamine amidotransferase-like	3	1
Oxidoreductase molybdopterin-binding domain	Riboflavin synthase domain-like	3	2
Voltage-gated potassium channels	Glycosyl hydrolase domain	3	3
Concanavalin A-like lectins/glucanases	PH domain-like	3	2
DEK C-terminal domain	ssDNA-binding transcriptional regulator domain	3	1
Oxidoreductase molybdopterin-binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
WD40 repeat-like	DPP6 N-terminal domain-like	3	2
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	3	2
WGR domain-like	ADP-ribosylation	3	3
PurS-like	PurM N-terminal domain-like	3	1
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	3	2
Elongation factor Ts (EF-Ts), dimerisation domain	Elongation factor Ts (EF-Ts), dimerisation domain	3	3
AN1-like Zinc finger	AN1-like Zinc finger	3	2
Heme oxygenase-like	HAD-like	3	2
Amidase signature (AS) enzymes	TPR-like	3	1
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	3	2
Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	3	1
Ribonuclease H-like	Nucleic acid-binding proteins	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	2	2
Toll/Interleukin receptor TIR domain	UBA-like	2	2
Class I glutamine amidotransferase-like	ADC synthase	2	1
RING/U-box	Ran binding protein zinc finger-like	2	1
Enolase C-terminal domain-like	alpha/beta-Hydrolases	2	1
Dcp2 domain-like	Nudix	2	1
"Winged helix" DNA-binding domain	F1F0 ATP synthase subunit A	2	1
cAMP-binding domain-like	Thioesterase/thiol ester dehydrase-isomerase	2	1
C-terminal, gelsolin-like domain of Sec23/24	VHP, Villin headpiece domain	2	1
Restriction endonuclease-like	RuvA domain 2-like	2	2
Outer arm dynein light chain 1	Protein kinase-like (PK-like)	2	2
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	2	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	2	1
Aldolase	NAD(P)-binding Rossmann-fold domains	2	1
PUA domain-like	Nucleotidylyl transferase	2	1
Translational machinery components	C-terminal domain of RNA polymerase alpha subunit	2	1
Histone-fold	NAP-like	2	1
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	2	1
F-box domain	Acid proteases	2	1
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	2	2
Acetyl-CoA synthetase-like	Trimeric LpxA-like enzymes	2	2
Formyltransferase	FMT C-terminal domain-like	2	1
Thiamin diphosphate-binding fold (THDP-binding)	Enolase N-terminal domain-like	2	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
Ribosomal protein S5 domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
FYVE/PHD zinc finger	CCCH zinc finger	2	1
HMA, heavy metal-associated domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Hypothetical protein c14orf129, hspc210	TPR-like	2	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	2	1
L domain-like	UBA-like	2	2
Mechanosensitive channel protein MscS (YggB), transmembrane region	Sm-like ribonucleoproteins	2	2
F-box domain	Leucine zipper domain	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	2	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	2	1
Glycerol-3-phosphate (1)-acyltransferase	EF-hand	2	1
Obg GTP-binding protein N-terminal domain	Obg GTP-binding protein C-terminal domain	2	1
DHS-like NAD/FAD-binding domain	Enolase N-terminal domain-like	2	1
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	2	1
Transmembrane di-heme cytochromes	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	2	1
TAZ domain	TAZ domain	2	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	2	2
YjeF N-terminal domain-like	FMN-binding split barrel	2	1
Urease, beta-subunit	Composite domain of metallo-dependent hydrolases	2	2
HIT/MYND zinc finger-like	RING/U-box	2	1
SWIB/MDM2 domain	CCCH zinc finger	2	1
Heme-dependent peroxidases	Heme-dependent peroxidases	2	1
Smc hinge domain	Tropomyosin	2	1
Protein kinase-like (PK-like)	HSP20-like chaperones	2	2
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	2	2
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
Urease, gamma-subunit	Metallo-dependent hydrolases	2	2
Mannose-binding lectins	Mannose-binding lectins	2	1
Probable bacterial effector-binding domain	Probable bacterial effector-binding domain	2	2
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	2	2
Putative isomerase YbhE	Quinoprotein alcohol dehydrogenase-like	2	1
cAMP-binding domain-like	Protein kinase-like (PK-like)	2	2
RNA-binding domain, RBD	Clavaminate synthase-like	2	1
RNA-binding domain, RBD	WW domain	2	1
P-loop containing nucleoside triphosphate hydrolases	FAD/NAD(P)-binding domain	2	1
Ribosomal protein S2	Nucleotide-diphospho-sugar transferases	2	1
Actin-like ATPase domain	AF1104-like	2	1
P-loop containing nucleoside triphosphate hydrolases	NAD(P)-binding Rossmann-fold domains	2	2
DHS-like NAD/FAD-binding domain	Enolase C-terminal domain-like	2	1
Thiamin diphosphate-binding fold (THDP-binding)	Enolase C-terminal domain-like	2	1
Tudor/PWWP/MBT	SAND domain-like	2	1
SAP domain	RNA-binding domain, RBD	2	1
BRCT domain	post-AAA+ oligomerization domain-like	2	1
Tricorn protease domain 2	WD40 repeat-like	2	2
Cytidine deaminase-like	YbiA-like	2	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleic acid-binding proteins	2	1
Galactose oxidase, central domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Retrovirus zinc finger-like domains	RNA-binding domain, RBD	2	2
Plus3-like	CCCH zinc finger	2	1
Cysteine proteinases	Protein kinase-like (PK-like)	2	2
CAD & PB1 domains	RING/U-box	2	1
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Class I glutamine amidotransferase-like	Ribulose-phoshate binding barrel	2	1
Thioredoxin-like	ERP29 C domain-like	2	1
ARM repeat	SH3-domain	2	2
GST C-terminal domain-like	Ypt/Rab-GAP domain of gyp1p	2	1
Concanavalin A-like lectins/glucanases	HSP20-like chaperones	2	2
RuvA domain 2-like	Nucleic acid-binding proteins	2	2
Ribonuclease H-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
SAND domain-like	SET domain	2	1
Urease, gamma-subunit	Composite domain of metallo-dependent hydrolases	2	2
ACP-like	Trimeric LpxA-like enzymes	2	2
PDZ domain-like	PDZ domain-like	2	1
HAD-like	dsRNA-binding domain-like	2	2
FAD/NAD(P)-binding domain	SMAD/FHA domain	2	1
Concanavalin A-like lectins/glucanases	RING/U-box	2	1
RuvA domain 2-like	RuvA domain 2-like	2	2
beta-sandwich domain of Sec23/24	Leucine zipper domain	2	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	2	1
Enolase N-terminal domain-like	alpha/beta-Hydrolases	2	1
Thiamin diphosphate-binding fold (THDP-binding)	alpha/beta-Hydrolases	2	1
NAD(P)-binding Rossmann-fold domains	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	2	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	2	2
HCP-like	Homing endonucleases	2	1
CAD & PB1 domains	UBA-like	2	1
TPR-like	Metallo-dependent phosphatases	2	1
GYF domain	SET domain	2	1
Ribose/Galactose isomerase RpiB/AlsB	RmlC-like cupins	2	1
HMA, heavy metal-associated domain	Toll/Interleukin receptor TIR domain	2	1
TPR-like	Ankyrin repeat	2	2
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	2	1
Photosystem I subunits PsaA/PsaB	Photosystem I subunits PsaA/PsaB	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	2	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	2	1
Tex N-terminal region-like	Ribonuclease H-like	2	2
Activator of Hsp90 ATPase, Aha1	Bet v1-like	2	1
Nqo1 middle domain-like	Nqo1C-terminal domain-like	2	1
F-box domain	SMI1/KNR4-like	2	2
Aldolase	Aminoacid dehydrogenase-like, N-terminal domain	2	1
ADP-ribosylation	Hemopexin-like domain	2	2
gp5 N-terminal domain-like	Phage fibre proteins	2	2
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	2	2
WD40 repeat-like	Bromodomain	2	1
BRCT domain	Domain of poly(ADP-ribose) polymerase	2	2
PDZ domain-like	TPR-like	2	1
PLP-dependent transferases	PLP-dependent transferases	2	2
L domain-like	Ubiquitin-like	2	2
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	2	1
Cytochrome f, large domain	Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor	2	1
Diaminopimelate epimerase-like	Diaminopimelate epimerase-like	2	1
Cysteine-rich domain	Cysteine-rich domain	2	2
Lipoxigenase	Class II aaRS and biotin synthetases	2	1
Ran binding protein zinc finger-like	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	2	1
RBP11-like subunits of RNA polymerase	C-terminal domain of RNA polymerase alpha subunit	2	1
PX domain	BAR/IMD domain-like	2	2
Cullin repeat-like	POZ domain	2	1
HD-domain/PDEase-like	TGS-like	2	2
BRCT domain	DNA polymerase beta, N-terminal domain-like	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	2	2
Clavaminate synthase-like	RING/U-box	2	2
FYVE/PHD zinc finger	SAND domain-like	2	1
Nucleic acid-binding proteins	BRCT domain	2	1
PDZ domain-like	(Phosphotyrosine protein) phosphatases II	2	2
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	2	1
Thioredoxin-like	Ypt/Rab-GAP domain of gyp1p	2	1
L domain-like	Leucine zipper domain	2	1
HydB/Nqo4-like	4Fe-4S ferredoxins	2	2
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	2	2
HIT/MYND zinc finger-like	HIT/MYND zinc finger-like	2	1
Plus3-like	GYF domain	2	1
DHS-like NAD/FAD-binding domain	alpha/beta-Hydrolases	2	1
Periplasmic binding protein-like II	GlnB-like	2	1
Phage tail proteins	gp5 N-terminal domain-like	2	2
YVTN repeat-like/Quinoprotein amine dehydrogenase	WD40 repeat-like	2	2
BRCT domain	PsbU/PolX domain-like	2	1
Actin depolymerizing proteins	C-terminal, gelsolin-like domain of Sec23/24	2	1
Surp module (SWAP domain)	ENTH/VHS domain	2	2
RING/U-box	Cyclophilin-like	2	1
Serine metabolism enzymes domain	ACT-like	2	2
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	2	1
Riboflavin synthase domain-like	Riboflavin synthase domain-like	2	1
Dihydrofolate reductase-like	YbiA-like	2	1
Translation proteins SH3-like domain	Ribosomal protein S19	2	1
HMG-box	HMG-box	2	2
CarD-like	TRCF domain-like	2	1
BRCT domain	ADP-ribosylation	2	2
Ribosomal proteins S24e, L23 and L15e	YWTD domain	2	1
cAMP-binding domain-like	cAMP-binding domain-like	2	2
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	Nucleic acid-binding proteins	2	1
Aspartate/glutamate racemase	Aspartate/glutamate racemase	2	1
BRCT domain	Nucleotidyltransferase	2	1
NAD(P)-binding Rossmann-fold domains	UDP-Glycosyltransferase/glycogen phosphorylase	2	2
SMAD/FHA domain	Phospholipase D/nuclease	2	2
Barwin-like endoglucanases	Protein kinase-like (PK-like)	2	1
Pseudouridine synthase	Pseudouridine synthase	2	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	2	1
Urease, gamma-subunit	Urease, beta-subunit	2	2
P-loop containing nucleoside triphosphate hydrolases	RuvA domain 2-like	2	1
Cullin repeat-like	Skp1 dimerisation domain-like	2	1
Nucleotidyltransferase	EF-hand	2	1
BSD domain-like	BSD domain-like	2	1
Chelatase	Chlorophyll a-b binding protein	2	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	2	1
cAMP-binding domain-like	ALDH-like	2	2
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	2	2
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	2	1
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	2	1
P-loop containing nucleoside triphosphate hydrolases	D-aminoacid aminotransferase-like PLP-dependent enzymes	2	2
NAD(P)-binding Rossmann-fold domains	Citrate synthase	2	1
FAD/NAD(P)-binding domain	HI0933 insert domain-like	2	1
Adenine nucleotide alpha hydrolases-like	Thioredoxin-like	2	2
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	2	1
Ran binding protein zinc finger-like	Translation proteins	2	1
UBC-like	RING/U-box	2	2
Fe-S cluster assembly (FSCA) domain-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Macro domain-like	Zn-dependent exopeptidases	2	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	2	2
TRAF domain-like	Kix domain of CBP (creb binding protein)	2	1
Thioredoxin-like	FAD-dependent thiol oxidase	2	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	2	1
Clavaminate synthase-like	beta-beta-alpha zinc fingers	2	2
BRCT domain	WGR domain-like	2	2
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	2	1
vWA-like	SPOC domain-like	2	2
Nitrite and sulphite reductase 4Fe-4S domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	2	2
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	2	2
ATP-dependent DNA ligase DNA-binding domain	BRCT domain	2	1
Nucleic acid-binding proteins	S15/NS1 RNA-binding domain	2	1
Single hybrid motif	Single hybrid motif	2	1
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	2	2
CarD-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Glucocorticoid receptor-like (DNA-binding domain)	HAD-like	2	2
PsbU/PolX domain-like	Nucleotidyltransferase	2	1
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	2	1
FYVE/PHD zinc finger	PUA domain-like	2	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	2	1
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	2	1
ARID-like	HSP20-like chaperones	2	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	2	1
Rudiment single hybrid motif	Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor	2	1
NTF2-like	Probable bacterial effector-binding domain	2	1
EF-hand	Calponin-homology domain, CH-domain	2	2
SWIB/MDM2 domain	GYF domain	2	1
Formate/glycerate dehydrogenase catalytic domain-like	Formate/glycerate dehydrogenase catalytic domain-like	2	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Eukaryotic type KH-domain (KH-domain type I)	2	1
Pentein	Pentein	2	1
HMA, heavy metal-associated domain	L domain-like	2	1
FAD/NAD(P)-binding domain	Acetyl-CoA synthetase-like	2	2
TPR-like	RNI-like	2	2
GroEL equatorial domain-like	DNA-binding domain	2	1
UraD-Like	Transthyretin (synonym: prealbumin)	2	1
Rhomboid-like	UBA-like	2	1
(Phosphotyrosine protein) phosphatases II	E set domains	2	2
Cytidine deaminase-like	Cytidine deaminase-like	2	1
FAD/NAD(P)-binding domain	ACP-like	2	2
GYF domain	CCCH zinc finger	2	1
FAD/NAD(P)-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	2	1
ARM repeat	alpha/beta-Hydrolases	2	1
FAD/NAD(P)-binding domain	Trimeric LpxA-like enzymes	2	2
F-box domain	alpha-D-mannose-specific plant lectins	2	1
Tricorn protease domain 2	Quinoprotein alcohol dehydrogenase-like	2	2
Methylglyoxal synthase-like	Cytidine deaminase-like	2	1
Calcyclin-binding protein-like	HSP20-like chaperones	2	1
F-box domain	NHL repeat	2	2
Insert subdomain of RNA polymerase alpha subunit	C-terminal domain of RNA polymerase alpha subunit	2	1
Toll/Interleukin receptor TIR domain	Elongation factor Ts (EF-Ts), dimerisation domain	2	2
Chaperone J-domain	Homeodomain-like	2	1
Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	2	2
WD40 repeat-like	SNARE fusion complex	2	2
Ran binding protein zinc finger-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Phage tail proteins	Phage fibre proteins	2	2
L domain-like	Cysteine proteinases	2	2
F-box domain	Clavaminate synthase-like	2	2
Acetyl-CoA synthetase-like	ACP-like	2	2
Nucleotidyltransferase	TGS-like	2	2
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	2	1
PGBD-like	DnaJ/Hsp40 cysteine-rich domain	2	1
PH domain-like	BSD domain-like	2	1
Ribonuclease H-like	RuvA domain 2-like	2	2
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	2	1
Six-hairpin glycosidases	AbfB domain	2	1
Cytochrome P450	Cytochrome P450	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	1
P-loop containing nucleoside triphosphate hydrolases	Glucocorticoid receptor-like (DNA-binding domain)	2	2
Tubulin nucleotide-binding domain-like	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	2	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	2	1
P-loop containing nucleoside triphosphate hydrolases	alpha/beta-Hydrolases	2	2
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	1
Urease, beta-subunit	Metallo-dependent hydrolases	2	2
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	2	2
PYP-like sensor domain (PAS domain)	F-box domain	2	2
Acyl-CoA binding protein	Kelch motif	2	2
FYVE/PHD zinc finger	TPR-like	2	1
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	2	2
Voltage-gated potassium channels	NAD(P)-binding Rossmann-fold domains	2	1
L30e-like	alpha/beta knot	2	1
P-loop containing nucleoside triphosphate hydrolases	Obg GTP-binding protein C-terminal domain	2	1
P-loop containing nucleoside triphosphate hydrolases	TRCF domain-like	2	1
UBA-like	PUG domain-like	2	2
SAP domain	DNase I-like	2	1
PP2C-like	cAMP-binding domain-like	2	2
HD-domain/PDEase-like	EF-hand	2	1
TolB, C-terminal domain	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain I	1	1
Toll/Interleukin receptor TIR domain	DNA-binding pseudobarrel domain	1	1
TK C-terminal domain-like	NAD(P)-binding Rossmann-fold domains	1	1
ACP-like	ACP-like	1	1
POZ domain	Galactose-binding domain-like	1	1
Phosphofructokinase	NAD(P)-binding Rossmann-fold domains	1	1
Ribosomal protein S8	RuBisCo, C-terminal domain	1	1
Protein kinase-like (PK-like)	Cytochrome P450	1	1
alpha-helical ferredoxin	FAD/NAD(P)-binding domain	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	1	1
DNA-binding pseudobarrel domain	Nucleic acid-binding proteins	1	1
F-box domain	LysM domain	1	1
Periplasmic binding protein-like II	MetI-like	1	1
Photosystem II 10 kDa phosphoprotein PsbH	Transmembrane di-heme cytochromes	1	1
WD40 repeat-like	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
Nucleic acid-binding proteins	Protein kinase-like (PK-like)	1	1
P-loop containing nucleoside triphosphate hydrolases	Typo IV secretion system protein TraC	1	1
HSP20-like chaperones	HSP20-like chaperones	1	1
MHC antigen-recognition domain	Protein kinase-like (PK-like)	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	MHC antigen-recognition domain	1	1
Cyclin-like	P-loop containing nucleoside triphosphate hydrolases	1	1
beta-beta-alpha zinc fingers	CCCH zinc finger	1	1
WD40 repeat-like	Cyclophilin-like	1	1
dsRNA-binding domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Terpenoid synthases	L domain-like	1	1
HMA, heavy metal-associated domain	FAD/NAD(P)-binding domain	1	1
Trimeric LpxA-like enzymes	ARM repeat	1	1
YggU-like	Glutathione synthetase ATP-binding domain-like	1	1
Ribonuclease Rh-like	Formin homology 2 domain (FH2 domain)	1	1
FMN-linked oxidoreductases	FAD/NAD(P)-binding domain	1	1
Thioredoxin-like	VC0467-like	1	1
TGS-like	Class II aaRS and biotin synthetases	1	1
Cysteine proteinases	Thioredoxin-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	RNA-binding domain, RBD	1	1
FAD/NAD(P)-binding domain	Nucleic acid-binding proteins	1	1
HydA/Nqo6-like	Nqo5-like	1	1
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	alpha/beta-Hydrolases	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
PH domain-like	Prismane protein-like	1	1
PRC-barrel domain	Nucleotide-diphospho-sugar transferases	1	1
DNA repair protein MutS, domain I	GIY-YIG endonuclease	1	1
Pseudo ankyrin repeat-like	TPR-like	1	1
ssDNA-binding transcriptional regulator domain	ssDNA-binding transcriptional regulator domain	1	1
vWA-like	SAP domain	1	1
FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	1	1
"Winged helix" DNA-binding domain	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
Staphylococcal nuclease	Staphylococcal nuclease	1	1
Lipocalins	Lipocalins	1	1
Ubiquitin-like	Bromodomain	1	1
Phage fibre proteins	Ankyrin repeat	1	1
Protein kinase-like (PK-like)	HCP-like	1	1
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	1	1
Cytochrome b559 subunits	Photosystem II reaction center protein L, PsbL	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	1	1
"Winged helix" DNA-binding domain	NosL/MerB-like	1	1
ARM repeat	Clavaminate synthase-like	1	1
POZ domain	Putative isomerase YbhE	1	1
Ankyrin repeat	Pseudo ankyrin repeat-like	1	1
RuBisCO, large subunit, small (N-terminal) domain	Ribosomal protein S8	1	1
SAM/Pointed domain	Metallo-hydrolase/oxidoreductase	1	1
Starch-binding domain-like	(Trans)glycosidases	1	1
Ribonuclease H-like	DNase I-like	1	1
Concanavalin A-like lectins/glucanases	Cysteine proteinases	1	1
"Winged helix" DNA-binding domain	Acetyl-CoA synthetase-like	1	1
HIT/MYND zinc finger-like	SET domain	1	1
Zinc beta-ribbon	Zinc beta-ribbon	1	1
POZ domain	Pentapeptide repeat-like	1	1
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	1	1
L domain-like	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Homeodomain-like	L domain-like	1	1
L domain-like	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
FYSH domain	beta-beta-alpha zinc fingers	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	TATA-box binding protein-like	1	1
WW domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
ARM repeat	FabD/lysophospholipase-like	1	1
WD40 repeat-like	P-loop containing nucleoside triphosphate hydrolases	1	1
PIN domain-like	Nucleic acid-binding proteins	1	1
PYP-like sensor domain (PAS domain)	Galactose oxidase, central domain	1	1
Carbohydrate phosphatase	HAD-like	1	1
YgbK-like	Aldolase	1	1
Nucleotide-diphospho-sugar transferases	ARM repeat	1	1
Protein kinase-like (PK-like)	BEACH domain	1	1
PA domain	EGF/Laminin	1	1
P-loop containing nucleoside triphosphate hydrolases	UBC-like	1	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	1	1
S15/NS1 RNA-binding domain	HydB/Nqo4-like	1	1
Calponin-homology domain, CH-domain	ARM repeat	1	1
PA domain	RING/U-box	1	1
Nucleotidyltransferase	ACT-like	1	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	1	1
FYVE/PHD zinc finger	RNI-like	1	1
Phosphoglycerate kinase	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Leucine zipper domain	Chaperone J-domain	1	1
Acetyl-CoA synthetase-like	Tetracyclin repressor-like, C-terminal domain	1	1
L domain-like	FabD/lysophospholipase-like	1	1
Skp1 dimerisation domain-like	Skp1 dimerisation domain-like	1	1
Metallo-hydrolase/oxidoreductase	TPR-like	1	1
Caspase-like	DNase I-like	1	1
Protein kinase-like (PK-like)	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
Ubiquitin-like	HAD-like	1	1
ARM repeat	"Winged helix" DNA-binding domain	1	1
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	1	1
gp5 N-terminal domain-like	Ankyrin repeat	1	1
TPR-like	Casein kinase II beta subunit	1	1
ARM repeat	Chaperone J-domain	1	1
Trimeric LpxA-like enzymes	Heme-dependent catalase-like	1	1
Nucleic acid-binding proteins	DNA-binding domain	1	1
FKBP-like	Triger factor/SurA peptide-binding domain-like	1	1
"Winged helix" DNA-binding domain	UBA-like	1	1
Ribosomal protein S2	F1F0 ATP synthase subunit A	1	1
Ankyrin repeat	DNA/RNA polymerases	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	"Winged helix" DNA-binding domain	1	1
Trigger factor ribosome-binding domain	FKBP-like	1	1
WGR domain-like	NAD(P)-binding Rossmann-fold domains	1	1
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	1	1
Pre-PUA domain	PUA domain-like	1	1
PUA domain-like	SWIB/MDM2 domain	1	1
PLP-dependent transferases	Clavaminate synthase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Ribonuclease Rh-like	1	1
PAH2 domain	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
HIT/MYND zinc finger-like	L domain-like	1	1
Cytochrome P450	Homeodomain-like	1	1
Protein kinase-like (PK-like)	Acyl-CoA dehydrogenase NM domain-like	1	1
Multidrug resistance efflux transporter EmrE	(Trans)glycosidases	1	1
XRCC4, N-terminal domain	XRCC4, C-terminal oligomerization domain	1	1
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	RING/U-box	1	1
Staphylococcal nuclease	Tudor/PWWP/MBT	1	1
CBS-domain pair	DNA-binding pseudobarrel domain	1	1
HMG-box	P-loop containing nucleoside triphosphate hydrolases	1	1
"Winged helix" DNA-binding domain	HRDC-like	1	1
HCP-like	RNI-like	1	1
ALDH-like	TPR-like	1	1
POZ domain	Quinoprotein alcohol dehydrogenase-like	1	1
Pectin lyase-like	Pectin lyase-like	1	1
Ankyrin repeat	RCC1/BLIP-II	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	Ribosomal protein S5 domain 2-like	1	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	Cytochrome c oxidase subunit II-like, transmembrane region	1	1
Quinoprotein alcohol dehydrogenase-like	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	1	1
NAD(P)-binding Rossmann-fold domains	RNI-like	1	1
Arabinanase/levansucrase/invertase	Arabinanase/levansucrase/invertase	1	1
TPR-like	Phospholipase D/nuclease	1	1
Protein kinase-like (PK-like)	NTF2-like	1	1
Mitochondrial carrier	Mitochondrial carrier	1	1
Nucleic acid-binding proteins	RNA-binding domain, RBD	1	1
Phage tail proteins	alpha/beta-Hydrolases	1	1
ALDH-like	ALDH-like	1	1
NAD(P)-binding Rossmann-fold domains	F-box domain	1	1
MFS general substrate transporter	Alkaline phosphatase-like	1	1
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	1	1
CheY-like	DNA-binding domain	1	1
SAP domain	CCCH zinc finger	1	1
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	1	1
Cyclin-like	L domain-like	1	1
ARM repeat	BEACH domain	1	1
alpha/beta-Hydrolases	FAD/NAD(P)-binding domain	1	1
AraD/HMP-PK domain-like	HAD-like	1	1
PDZ domain-like	Rubredoxin-like	1	1
Zn-dependent exopeptidases	L domain-like	1	1
Band 7/SPFH domain	DNA/RNA polymerases	1	1
Chromo domain-like	Ankyrin repeat	1	1
AN1-like Zinc finger	beta-beta-alpha zinc fingers	1	1
NAD(P)-binding Rossmann-fold domains	YgbK-like	1	1
P-loop containing nucleoside triphosphate hydrolases	NTF2-like	1	1
Metalloproteases ("zincins"), catalytic domain	ARM repeat	1	1
Ribosomal protein S8	Ribosomal protein L36	1	1
vWA-like	C-terminal domain of Ku80	1	1
Metalloproteases ("zincins"), catalytic domain	OmpA-like	1	1
Rudiment single hybrid motif	ClpP/crotonase	1	1
Adenine nucleotide alpha hydrolases-like	Molybdenum cofactor biosynthesis proteins	1	1
SPOC domain-like	C-terminal domain of Ku80	1	1
Ribonuclease H-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Carbohydrate phosphatase	NAD(P)-binding Rossmann-fold domains	1	1
Multidrug resistance efflux transporter EmrE	ENTH/VHS domain	1	1
HCP-like	Phospholipase D/nuclease	1	1
Acyl-CoA binding protein	Ankyrin repeat	1	1
Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin	1	1
P-loop containing nucleoside triphosphate hydrolases	Methyl-accepting chemotaxis protein (MCP) signaling domain	1	1
RNI-like	WD40 repeat-like	1	1
P-loop containing nucleoside triphosphate hydrolases	TK C-terminal domain-like	1	1
Pectin lyase-like	L domain-like	1	1
CBS-domain pair	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
SSo0622-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	tRNA-binding arm	1	1
Tudor/PWWP/MBT	P-loop containing nucleoside triphosphate hydrolases	1	1
Peptidase/esterase 'gauge' domain	SNARE fusion complex	1	1
Terpenoid synthases	Protein kinase-like (PK-like)	1	1
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	RNA-binding domain, RBD	1	1
Phosphoglycerate mutase-like	Phosphoglycerate mutase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
C-type lectin-like	Protein kinase-like (PK-like)	1	1
Cytochrome b5-like heme/steroid binding domain	alpha/beta-Hydrolases	1	1
SWIB/MDM2 domain	eIF1-like	1	1
P-loop containing nucleoside triphosphate hydrolases	GIY-YIG endonuclease	1	1
Toll/Interleukin receptor TIR domain	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
Toll/Interleukin receptor TIR domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
C-terminal domain of alpha and beta subunits of F1 ATP synthase	Cupredoxins	1	1
WD40 repeat-like	TPR-like	1	1
FKBP-like	Rhodanese/Cell cycle control phosphatase	1	1
Acetyl-CoA synthetase-like	Homeodomain-like	1	1
F-box domain	DPP6 N-terminal domain-like	1	1
Thioredoxin-like	Six-hairpin glycosidases	1	1
Nucleic acid-binding proteins	L domain-like	1	1
Nucleotide-binding domain	Nucleotide-binding domain	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	Clavaminate synthase-like	1	1
Band 7/SPFH domain	Band 7/SPFH domain	1	1
Translation proteins	PRC-barrel domain	1	1
TGS-like	Class II aaRS ABD-related	1	1
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	1	1
Nucleotidylyl transferase	tRNA-binding arm	1	1
Subtilisin-like	Cytidine deaminase-like	1	1
Oxygen-evolving enhancer protein 3,	Cyclophilin-like	1	1
Taf5 N-terminal domain-like	WD40 repeat-like	1	1
HD-domain/PDEase-like	ACT-like	1	1
MHC antigen-recognition domain	ARM repeat	1	1
Kix domain of CBP (creb binding protein)	Kix domain of CBP (creb binding protein)	1	1
P-loop containing nucleoside triphosphate hydrolases	Thiamin diphosphate-binding fold (THDP-binding)	1	1
ARM repeat	Acid proteases	1	1
Phosphoenolpyruvate/pyruvate domain	ENTH/VHS domain	1	1
WD40 repeat-like	Ribonuclease H-like	1	1
RING/U-box	Leucine zipper domain	1	1
lambda repressor-like DNA-binding domains	Cyanase C-terminal domain	1	1
TPR-like	Calcium-dependent phosphotriesterase	1	1
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	1	1
Alpha subunit of glutamate synthase, C-terminal domain	alpha-helical ferredoxin	1	1
RNI-like	NTF2-like	1	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
RNI-like	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
Nucleic acid-binding proteins	SMAD/FHA domain	1	1
Serpins	P-loop containing nucleoside triphosphate hydrolases	1	1
Cullin repeat-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Metallo-hydrolase/oxidoreductase	Protein kinase-like (PK-like)	1	1
N-terminal domain of MutM-like DNA repair proteins	S13-like H2TH domain	1	1
Ankyrin repeat	Translation initiation factor IF3, N-terminal domain	1	1
Rudiment single hybrid motif	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
Cna protein B-type domain	Carboxypeptidase regulatory domain-like	1	1
Type II DNA topoisomerase	GyrA/ParC C-terminal domain-like	1	1
Cryptochrome/photolyase, N-terminal domain	alpha/beta-Hydrolases	1	1
Translation proteins	Nucleotide-diphospho-sugar transferases	1	1
F-box domain	FtsH protease domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Retrovirus zinc finger-like domains	1	1
SAP domain	Domain of poly(ADP-ribose) polymerase	1	1
Putative isomerase YbhE	ARM repeat	1	1
Typo IV secretion system protein TraC	NTF2-like	1	1
ISP domain	Chlorophyll a-b binding protein	1	1
Sec1/munc18-like (SM) proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
PH domain-like	"Winged helix" DNA-binding domain	1	1
Glutathione synthetase ATP-binding domain-like	Phosphohistidine domain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	alpha-D-mannose-specific plant lectins	1	1
Ribonuclease H-like	SH2 domain	1	1
FYVE/PHD zinc finger	F-box domain	1	1
Thiamin diphosphate-binding fold (THDP-binding)	NAD(P)-binding Rossmann-fold domains	1	1
lambda repressor-like DNA-binding domains	RmlC-like cupins	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	1	1
Macro domain-like	HIT-like	1	1
ValRS/IleRS/LeuRS editing domain	tRNA-binding arm	1	1
RNI-like	SGNH hydrolase	1	1
DNA/RNA polymerases	DNA/RNA polymerases	1	1
TPR-like	F-box domain	1	1
SAP domain	ADP-ribosylation	1	1
TolB, C-terminal domain	Quinoprotein alcohol dehydrogenase-like	1	1
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	1	1
Tex N-terminal region-like	Nucleic acid-binding proteins	1	1
F-box domain	ApaG-like	1	1
UBC-like	Class II aaRS and biotin synthetases	1	1
TGS-like	ThrRS/AlaRS common domain	1	1
F-box domain	YWTD domain	1	1
L domain-like	V-type ATP synthase subunit C	1	1
HCP-like	Argininosuccinate synthetase, C-terminal domain	1	1
Rhodanese/Cell cycle control phosphatase	alpha/beta-Hydrolases	1	1
PUA domain-like	eIF1-like	1	1
ClpP/crotonase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	1	1
HAD-like	Nucleotide-diphospho-sugar transferases	1	1
Ribosomal protein S2	S-adenosyl-L-methionine-dependent methyltransferases	1	1
beta-beta-alpha zinc fingers	Ankyrin repeat	1	1
Protein kinase-like (PK-like)	PR-1-like	1	1
D-aminoacid aminotransferase-like PLP-dependent enzymes	D-aminoacid aminotransferase-like PLP-dependent enzymes	1	1
Poly A polymerase C-terminal region-like	Poly A polymerase C-terminal region-like	1	1
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Cytochrome c oxidase subunit II-like, transmembrane region	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	1	1
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	1	1
Glutathione synthetase ATP-binding domain-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
Phage tail proteins	Ankyrin repeat	1	1
ARM repeat	F-box domain	1	1
Carbohydrate phosphatase	TK C-terminal domain-like	1	1
Cna protein B-type domain	Cna protein B-type domain	1	1
GroES-like	DNA/RNA polymerases	1	1
DNA-binding pseudobarrel domain	Ribonuclease H-like	1	1
"Winged helix" DNA-binding domain	DNA-binding pseudobarrel domain	1	1
F-box domain	Pectin lyase-like	1	1
Sec1/munc18-like (SM) proteins	Sec1/munc18-like (SM) proteins	1	1
Protein kinase-like (PK-like)	RuBisCo, C-terminal domain	1	1
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	1	1
Phage fibre proteins	Tricorn protease N-terminal domain	1	1
HAD-like	RmlC-like cupins	1	1
Lipoxigenase	Metal cation-transporting ATPase, ATP-binding domain N	1	1
FAD/NAD(P)-binding domain	DNA-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	PLP-dependent transferases	1	1
Aquaporin-like	P-loop containing nucleoside triphosphate hydrolases	1	1
RNI-like	RuBisCo, C-terminal domain	1	1
Nucleotide-diphospho-sugar transferases	RmlC-like cupins	1	1
Fe-S cluster assembly (FSCA) domain-like	FKBP-like	1	1
TPR-like	RNA-binding domain, RBD	1	1
SSo0622-like	Kelch motif	1	1
P-loop containing nucleoside triphosphate hydrolases	Cupredoxins	1	1
(Phosphotyrosine protein) phosphatases II	RNA-binding domain, RBD	1	1
Putative isomerase YbhE	RING/U-box	1	1
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	1	1
WD40 repeat-like	Galactose oxidase, central domain	1	1
5' to 3' exonuclease, C-terminal subdomain	Chromo domain-like	1	1
MetI-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Terpenoid synthases	Terpenoid synthases	1	1
Rad51 N-terminal domain-like	ARM repeat	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
FYVE/PHD zinc finger	Bromodomain	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	alpha/beta-Hydrolases	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	Dihydropteroate synthetase-like	1	1
Phosphoglucomutase, C-terminal domain	Phosphoglucomutase, C-terminal domain	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
Putative cyclase	YjgF-like	1	1
DNase I-like	Clavaminate synthase-like	1	1
TPR-like	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	1	1
Protein kinase-like (PK-like)	Class II aaRS and biotin synthetases	1	1
Ribonuclease H-like	Protein kinase-like (PK-like)	1	1
F-box domain	NTF2-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	PLP-dependent transferases	1	1
UBA-like	NSFL1 (p97 ATPase) cofactor p47, SEP domain	1	1
Carbamate kinase-like	Carbamate kinase-like	1	1
Nucleic acid-binding proteins	S-adenosyl-L-methionine-dependent methyltransferases	1	1
PreATP-grasp domain	ClpP/crotonase	1	1
L9 N-domain-like	Ribosomal protein L9 C-domain	1	1
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	1	1
GST C-terminal domain-like	Nucleic acid-binding proteins	1	1
Acetyl-CoA synthetase-like	Quinoprotein alcohol dehydrogenase-like	1	1
Subunit IX of photosystem I reaction centre, PsaJ	Zn-binding ribosomal proteins	1	1
Nucleic acid-binding proteins	SH2 domain	1	1
Acyl-CoA N-acyltransferases (Nat)	BRCT domain	1	1
RNA-binding domain, RBD	Surp module (SWAP domain)	1	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	Cupredoxins	1	1
Translation proteins SH3-like domain	Translation proteins SH3-like domain	1	1
Single hybrid motif	ClpP/crotonase	1	1
SufE/NifU	NadA-like	1	1
Quinoprotein alcohol dehydrogenase-like	DPP6 N-terminal domain-like	1	1
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	1	1
Homeodomain-like	TATA-box binding protein-like	1	1
beta-sandwich domain of Sec23/24	Ribosomal protein L1	1	1
FYVE/PHD zinc finger	Actin-like ATPase domain	1	1
MIT domain	MIT domain	1	1
Aconitase iron-sulfur domain	Oxysterol-binding protein-like	1	1
P-loop containing nucleoside triphosphate hydrolases	HAD-like	1	1
FAD/NAD(P)-binding domain	Thioredoxin-like	1	1
TGS-like	ACT-like	1	1
PLP-dependent transferases	(Trans)glycosidases	1	1
Acyl-CoA dehydrogenase C-terminal domain-like	Thioesterase/thiol ester dehydrase-isomerase	1	1
Protein prenylyltransferase	L domain-like	1	1
Carbamate kinase-like	Acyl-CoA N-acyltransferases (Nat)	1	1
MurE/MurF N-terminal domain	MurD-like peptide ligases, peptide-binding domain	1	1
Cysteine proteinases	DNA-binding pseudobarrel domain	1	1
ClpP/crotonase	Thiolase-like	1	1
Mog1p/PsbP-like	CRAL/TRIO domain	1	1
EPT/RTPC-like	EPT/RTPC-like	1	1
NAC domain	NAC domain	1	1
Concanavalin A-like lectins/glucanases	Calpain large subunit, middle domain (domain III)	1	1
Prokaryotic type I DNA topoisomerase	Retrovirus zinc finger-like domains	1	1
DNA clamp	DNA clamp	1	1
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	SMR domain-like	1	1
L domain-like	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
WD40 repeat-like	NHL repeat	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	1	1
RNA-binding domain, RBD	N-terminal domain of alpha and beta subunits of F1 ATP synthase	1	1
Thioredoxin-like	Ribonuclease Rh-like	1	1
Thiolase-like	WD40 repeat-like	1	1
SNARE-like	SNARE-like	1	1
ISP transmembrane anchor	ISP domain	1	1
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	1	1
Carbohydrate phosphatase	Thiamin diphosphate-binding fold (THDP-binding)	1	1
HMA, heavy metal-associated domain	Cu,Zn superoxide dismutase-like	1	1
R3H domain	Ankyrin repeat	1	1
CoA-dependent acyltransferases	CoA-dependent acyltransferases	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	Phosphoglycerate kinase	1	1
Protease propeptides/inhibitors	PA domain	1	1
Ribosomal protein L14	Translational machinery components	1	1
Tricorn protease domain 2	alpha/beta-Hydrolases	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	GHMP Kinase, C-terminal domain	1	1
Cysteine-rich domain	Caspase-like	1	1
Periplasmic binding protein-like I	Periplasmic binding protein-like I	1	1
Eukaryotic type KH-domain (KH-domain type I)	Retrovirus zinc finger-like domains	1	1
N-utilization substance G protein NusG, N-terminal domain	Translation proteins SH3-like domain	1	1
POZ domain	WD40 repeat-like	1	1
UBC-like	UBC-like	1	1
Protein kinase-like (PK-like)	Homeodomain-like	1	1
Aldolase	Ribulose-phoshate binding barrel	1	1
DPP6 N-terminal domain-like	HCP-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	1	1
Homeodomain-like	Toll/Interleukin receptor TIR domain	1	1
Nucleic acid-binding proteins	UBA-like	1	1
Cytochrome P450	Calcium-dependent phosphotriesterase	1	1
Ribosomal protein L16p/L10e	Ribosomal protein L14	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	1	1
NAD(P)-binding Rossmann-fold domains	DNA/RNA polymerases	1	1
P-loop containing nucleoside triphosphate hydrolases	Prismane protein-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	alpha-helical ferredoxin	1	1
UBC-like	Class II aaRS ABD-related	1	1
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	1	1
F-box domain	Glutathione synthetase ATP-binding domain-like	1	1
Acid proteases	Nucleic acid-binding proteins	1	1
"Winged helix" DNA-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Metallo-hydrolase/oxidoreductase	Casein kinase II beta subunit	1	1
EF-hand	TPR-like	1	1
Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain III	1	1
GST C-terminal domain-like	Ribosomal protein L25-like	1	1
L domain-like	RING/U-box	1	1
Nucleic acid-binding proteins	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
Ubiquitin-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Zn-dependent exopeptidases	Protein kinase-like (PK-like)	1	1
CCCH zinc finger	S-adenosyl-L-methionine-dependent methyltransferases	1	1
FAD/NAD(P)-binding domain	NosL/MerB-like	1	1
UBA-like	post-AAA+ oligomerization domain-like	1	1
Ribonuclease Rh-like	Ribonuclease Rh-like	1	1
Fucose-specific lectin	Fucose-specific lectin	1	1
FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	1	1
L domain-like	Actin-crosslinking proteins	1	1
Starch-binding domain-like	Starch-binding domain-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	Thiolase-like	1	1
Pectin lyase-like	RmlC-like cupins	1	1
TK C-terminal domain-like	HAD-like	1	1
Glutamine synthetase/guanido kinase	GatB/YqeY motif	1	1
Homeodomain-like	F-box domain	1	1
GST C-terminal domain-like	Nucleotidylyl transferase	1	1
L domain-like	DNA-binding pseudobarrel domain	1	1
Phage tail proteins	Tricorn protease N-terminal domain	1	1
Ribonuclease Rh-like	Protein kinase-like (PK-like)	1	1
PH domain-like	(Phosphotyrosine protein) phosphatases II	1	1
Tex N-terminal region-like	RuvA domain 2-like	1	1
Ribokinase-like	Thiamin phosphate synthase	1	1
F-box domain	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FAD/NAD(P)-binding domain	1	1
Homeodomain-like	Photosystem I subunits PsaA/PsaB	1	1
Terpenoid synthases	Outer arm dynein light chain 1	1	1
ACP-like	Heme-dependent catalase-like	1	1
beta-sandwich domain of Sec23/24	Acid proteases	1	1
Six-hairpin glycosidases	Tautomerase/MIF	1	1
Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	1	1
Cna protein B-type domain	Starch-binding domain-like	1	1
Starch-binding domain-like	Nucleic acid-binding proteins	1	1
Bromodomain	Nucleic acid-binding proteins	1	1
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	1	1
Class II aaRS and biotin synthetases	Class II aaRS and biotin synthetases	1	1
GroES-like	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	YgbK-like	1	1
Outer arm dynein light chain 1	RNI-like	1	1
UBC-like	Protein kinase-like (PK-like)	1	1
FAD-binding/transporter-associated domain-like	DNA-binding pseudobarrel domain	1	1
L domain-like	Glutathione synthetase ATP-binding domain-like	1	1
Eukaryotic RPB5 N-terminal domain	Eukaryotic RPB5 N-terminal domain	1	1
Sec63 N-terminal domain-like	DNA/RNA polymerases	1	1
TAF(II)230 TBP-binding fragment	Bromodomain	1	1
HMA, heavy metal-associated domain	NosL/MerB-like	1	1
Retrovirus zinc finger-like domains	Actin depolymerizing proteins	1	1
R3H domain	P-loop containing nucleoside triphosphate hydrolases	1	1
ARID-like	Homeodomain-like	1	1
DNA-glycosylase	DNase I-like	1	1
"Winged helix" DNA-binding domain	Periplasmic binding protein-like II	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	Homeodomain-like	1	1
Plant lectins/antimicrobial peptides	Barwin-like endoglucanases	1	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	1	1
ARM repeat	Concanavalin A-like lectins/glucanases	1	1
HIT/MYND zinc finger-like	Protein kinase-like (PK-like)	1	1
NusB-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
gp5 N-terminal domain-like	Tricorn protease N-terminal domain	1	1
WD40 repeat-like	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
SGNH hydrolase	SGNH hydrolase	1	1
FAD/NAD(P)-binding domain	"Winged helix" DNA-binding domain	1	1
Chaperone J-domain	Multiheme cytochromes	1	1
Aquaporin-like	HMA, heavy metal-associated domain	1	1
NAD(P)-binding Rossmann-fold domains	Thiolase-like	1	1
SAP domain	WGR domain-like	1	1
Acyl-CoA N-acyltransferases (Nat)	RNA-binding domain, RBD	1	1
beta-Galactosidase/glucuronidase domain	Galactose mutarotase-like	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
ARM repeat	alpha/beta knot	1	1
DNA primase core	P-loop containing nucleoside triphosphate hydrolases	1	1
Ribulose-phoshate binding barrel	HAD-like	1	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
RNA-binding domain, RBD	ENTH/VHS domain	1	1
WD40 repeat-like	Peptidase/esterase 'gauge' domain	1	1
PreATP-grasp domain	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
DNA-glycosylase	Nudix	1	1
alpha/beta-Hydrolases	HCP-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
FYVE/PHD zinc finger	Chromo domain-like	1	1
TAF(II)230 TBP-binding fragment	Ubiquitin-like	1	1
gp5 N-terminal domain-like	gp5 N-terminal domain-like	1	1
Protein kinase-like (PK-like)	beta-lactamase/transpeptidase-like	1	1
Dimeric alpha+beta barrel	Dehydroquinate synthase-like	1	1
F-box domain	Calcium-dependent phosphotriesterase	1	1
Metallo-hydrolase/oxidoreductase	alpha/beta-Hydrolases	1	1
CBS-domain pair	FAD-binding/transporter-associated domain-like	1	1
C-terminal UvrC-binding domain of UvrB	ApaG-like	1	1
MurE/MurF N-terminal domain	MurD-like peptide ligases, catalytic domain	1	1
Metallo-dependent phosphatases	Metallo-dependent phosphatases	1	1
Oxysterol-binding protein-like	LeuD/IlvD-like	1	1
Clavaminate synthase-like	Protein kinase-like (PK-like)	1	1
Ankyrin repeat	S-adenosyl-L-methionine-dependent methyltransferases	1	1
SPOC domain-like	SAP domain	1	1
JAB1/MPN domain	cAMP-binding domain-like	1	1
Acetyl-CoA synthetase-like	Heme-dependent catalase-like	1	1
Phosphofructokinase	"Winged helix" DNA-binding domain	1	1
L domain-like	alpha/beta-Hydrolases	1	1
Ribonuclease H-like	Alkaline phosphatase-like	1	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	1	1
HMG-box	Leucine zipper domain	1	1
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
P-loop containing nucleoside triphosphate hydrolases	HIT-like	1	1
Myosin S1 fragment, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Ribosomal proteins S24e, L23 and L15e	Translation proteins SH3-like domain	1	1
Nucleic acid-binding proteins	F-box domain	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	ACT-like	1	1
DNA breaking-rejoining enzymes	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
Kix domain of CBP (creb binding protein)	Protein kinase-like (PK-like)	1	1
Kelch motif	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Starch-binding domain-like	Glutathione synthetase ATP-binding domain-like	1	1
Aldolase	HAD-like	1	1
Alpha subunit of glutamate synthase, C-terminal domain	FAD/NAD(P)-binding domain	1	1
Ran binding protein zinc finger-like	DNase I-like	1	1
FAD-linked reductases, C-terminal domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
WGR domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	1	1
gp5 N-terminal domain-like	alpha/beta-Hydrolases	1	1
RuvA domain 2-like	SH2 domain	1	1
Ankyrin repeat	Translation initiation factor IF3, C-terminal domain	1	1
Trigger factor ribosome-binding domain	Triger factor/SurA peptide-binding domain-like	1	1
C-terminal domain of alpha and beta subunits of F1 ATP synthase	Cytochrome c oxidase subunit II-like, transmembrane region	1	1
NAD(P)-binding Rossmann-fold domains	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
P-loop containing nucleoside triphosphate hydrolases	Pili subunits	1	1
Zn-binding ribosomal proteins	Ribosomal protein S18	1	1
AF0104/ALDC/Ptd012-like	AF0104/ALDC/Ptd012-like	1	1
alpha/beta knot	Nucleic acid-binding proteins	1	1
Homeodomain-like	Tetracyclin repressor-like, C-terminal domain	1	1
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Zn-dependent exopeptidases	NAC domain	1	1
"Winged helix" DNA-binding domain	GAF domain-like	1	1
Hypothetical protein AF0491, middle domain	beta-beta-alpha zinc fingers	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	PLP-dependent transferases	1	1
PLP-dependent transferases	MOSC N-terminal domain-like	1	1
N-terminal domain of adenylylcyclase associated protein, CAP	C-terminal domain of adenylylcyclase associated protein	1	1
Pseudouridine synthase	PUA domain-like	1	1
DNA repair protein MutS, domain III	SMR domain-like	1	1
ARM repeat	Ribosomal protein L4	1	1
DEK C-terminal domain	SWIB/MDM2 domain	1	1
Type II DNA topoisomerase	Type II DNA topoisomerase	1	1
SMI1/KNR4-like	ApaG-like	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Arabinanase/levansucrase/invertase	Nucleotide-diphospho-sugar transferases	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	1	1
RNI-like	alpha/beta-Hydrolases	1	1
PreATP-grasp domain	Methylglyoxal synthase-like	1	1
PUA domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Starch-binding domain-like	Carboxypeptidase regulatory domain-like	1	1
Protein kinase-like (PK-like)	Class II aaRS ABD-related	1	1
FMN-linked oxidoreductases	alpha-helical ferredoxin	1	1
F-box domain	SET domain	1	1
Cullin repeat-like	WRKY DNA-binding domain	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	alpha/beta-Hydrolases	1	1
Helical scaffold and wing domains of SecA	Helical scaffold and wing domains of SecA	1	1
Concanavalin A-like lectins/glucanases	SH2 domain	1	1
RNA-binding domain, RBD	DPP6 N-terminal domain-like	1	1
Nucleic acid-binding proteins	Ribosomal protein S7	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	1	1
DAK1/DegV-like	DhaL-like	1	1
Tudor/PWWP/MBT	Tudor/PWWP/MBT	1	1
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleic acid-binding proteins	TPR-like	1	1
Phage fibre proteins	alpha/beta-Hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	Cysteine proteinases	1	1
HAD-like	NAD(P)-binding Rossmann-fold domains	1	1
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	1	1
WGR domain-like	Phosphofructokinase	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain II	1	1
Acid proteases	Acid proteases	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Protein kinase-like (PK-like)	1	1
Second domain of FERM	Prismane protein-like	1	1
Phosphofructokinase	P-loop containing nucleoside triphosphate hydrolases	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	1	1
TPR-like	FAD/NAD(P)-binding domain	1	1
NAD(P)-binding Rossmann-fold domains	"Winged helix" DNA-binding domain	1	1
PDZ domain-like	E set domains	1	1
F-box domain	Outer arm dynein light chain 1	1	1
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	1	1
Metallo-dependent hydrolases	Metallo-dependent hydrolases	1	1
Thiamin diphosphate-binding fold (THDP-binding)	HAD-like	1	1
FAD/NAD(P)-binding domain	Heme-dependent catalase-like	1	1
alpha/beta-Hydrolases	Ankyrin repeat	1	1
Phage fibre proteins	Phage fibre proteins	1	1
PYP-like sensor domain (PAS domain)	Kelch motif	1	1
Rhomboid-like	Ran binding protein zinc finger-like	1	1
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
Leucine zipper domain	Leucine zipper domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	1	1
WD40 repeat-like	Toll/Interleukin receptor TIR domain	1	1
Photosystem II reaction center protein K, PsbK	Photosystem II reaction center protein I, PsbI	1	1
P-loop containing nucleoside triphosphate hydrolases	Carbohydrate phosphatase	1	1
WD40 repeat-like	Nucleoporin domain	1	1
GAF domain-like	Acetyl-CoA synthetase-like	1	1
Phosphoenolpyruvate/pyruvate domain	Multidrug resistance efflux transporter EmrE	1	1
Cap-Gly domain	L domain-like	1	1
Protein kinase-like (PK-like)	Metal cation-transporting ATPase, ATP-binding domain N	1	1
Leukotriene A4 hydrolase N-terminal domain	ARM repeat	1	1
CCCH zinc finger	WD40 repeat-like	1	1
GYF domain	RNA-binding domain, RBD	1	1
L domain-like	ARM repeat	1	1
PIN domain-like	Chromo domain-like	1	1
Photosystem II antenna protein-like	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
Acyl-CoA dehydrogenase NM domain-like	Thioesterase/thiol ester dehydrase-isomerase	1	1
UBC-like	Endosomal sorting complex assembly domain	1	1