Domain combination pairs in Medicago truncatula

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

1737 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
P-loop containing nucleoside triphosphate hydrolases	L domain-like	873	131
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	470	94
L domain-like	L domain-like	469	109
L domain-like	Protein kinase-like (PK-like)	446	48
Toll/Interleukin receptor TIR domain	P-loop containing nucleoside triphosphate hydrolases	423	73
F-box domain	RNI-like	383	18
Toll/Interleukin receptor TIR domain	L domain-like	361	62
RNI-like	L domain-like	333	107
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	310	65
Toll/Interleukin receptor TIR domain	"Winged helix" DNA-binding domain	253	48
"Winged helix" DNA-binding domain	L domain-like	253	51
RNA-binding domain, RBD	RNA-binding domain, RBD	208	26
alpha-D-mannose-specific plant lectins	Protein kinase-like (PK-like)	201	12
P-loop containing nucleoside triphosphate hydrolases	RNI-like	182	60
Actin-like ATPase domain	Actin-like ATPase domain	145	24
RNI-like	RNI-like	144	53
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	137	13
ABC transporter transmembrane region	ABC transporter transmembrane region	110	9
F-box domain	Galactose oxidase, central domain	105	5
Nucleic acid-binding proteins	Nucleic acid-binding proteins	102	25
RNI-like	Protein kinase-like (PK-like)	101	29
GroES-like	NAD(P)-binding Rossmann-fold domains	96	7
TPR-like	TPR-like	95	26
Thioredoxin-like	GST C-terminal domain-like	95	7
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	93	7
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	92	22
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	92	17
Calcium ATPase, transmembrane domain M	HAD-like	91	17
Calcium ATPase, transduction domain A	HAD-like	88	15
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	81	14
RING/U-box	ARM repeat	74	10
ARM repeat	ARM repeat	73	34
Thiolase-like	Thiolase-like	72	3
Cyclin-like	Cyclin-like	71	8
DNA-binding pseudobarrel domain	DNA-binding pseudobarrel domain	69	13
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	66	9
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	66	9
"Winged helix" DNA-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	66	2
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	65	5
Galactose-binding domain-like	(Trans)glycosidases	63	12
Plant invertase/pectin methylesterase inhibitor	Pectin lyase-like	63	2
RING/U-box	RING/U-box	58	20
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	57	7
Calcium ATPase, transmembrane domain M	Metal cation-transporting ATPase, ATP-binding domain N	56	6
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	56	9
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	54	6
Cupredoxins	Cupredoxins	54	5
Periplasmic binding protein-like I	Periplasmic binding protein-like II	54	5
POZ domain	Skp1 dimerisation domain-like	53	4
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	53	4
Terpenoid cyclases/Protein prenyltransferases	Terpenoid synthases	53	5
Concanavalin A-like lectins/glucanases	Protein kinase-like (PK-like)	50	9
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	50	8
Toll/Interleukin receptor TIR domain	Toll/Interleukin receptor TIR domain	49	18
(Trans)glycosidases	Glycosyl hydrolase domain	48	11
F-box domain	L domain-like	47	10
Barwin-like endoglucanases	PHL pollen allergen	47	1
Homeodomain-like	Homeodomain-like	46	14
Voltage-gated potassium channels	cAMP-binding domain-like	46	5
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	45	9
CheY-like	Homeodomain-like	45	5
Protein kinase-like (PK-like)	EF-hand	44	2
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	43	11
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	42	6
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	42	6
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	41	8
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	41	5
CCCH zinc finger	CCCH zinc finger	40	17
Ubiquitin-like	Ubiquitin-like	40	10
DNA-binding domain	DNA-binding domain	39	5
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	39	5
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipoxigenase	38	2
Ran binding protein zinc finger-like	RNA-binding domain, RBD	38	3
F-box domain	Kelch motif	38	6
FYVE/PHD zinc finger	FYVE/PHD zinc finger	37	18
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	37	6
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	36	12
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	36	8
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	36	14
Galactose-binding domain-like	Galactose-binding domain-like	36	4
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	35	7
ACT-like	ACT-like	33	12
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	32	6
Terpenoid cyclases/Protein prenyltransferases	Terpenoid cyclases/Protein prenyltransferases	30	6
(Trans)glycosidases	Beta-D-glucan exohydrolase, C-terminal domain	29	2
SET domain	PUA domain-like	29	3
ENTH/VHS domain	GAT-like domain	29	3
RING/U-box	Nucleotide-diphospho-sugar transferases	28	3
WRKY DNA-binding domain	WRKY DNA-binding domain	28	2
vWA-like	RING/U-box	28	4
DNA-binding pseudobarrel domain	CAD & PB1 domains	28	4
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	27	7
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	27	3
Purple acid phosphatase, N-terminal domain	Metallo-dependent phosphatases	27	4
Cullin homology domain	"Winged helix" DNA-binding domain	27	4
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	26	15
Surp module (SWAP domain)	Surp module (SWAP domain)	26	3
ACT-like	Protein kinase-like (PK-like)	26	2
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	26	7
FYVE/PHD zinc finger	Acyl-CoA N-acyltransferases (Nat)	25	8
Phospholipase D/nuclease	Phospholipase D/nuclease	25	9
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	25	10
PAH2 domain	PAH2 domain	24	7
GroEL equatorial domain-like	GroEL apical domain-like	24	6
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	SAICAR synthase-like	24	6
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	24	5
P-loop containing nucleoside triphosphate hydrolases	E set domains	24	4
Adenine nucleotide alpha hydrolases-like	Protein kinase-like (PK-like)	23	4
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	23	4
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	23	8
Clc chloride channel	CBS-domain pair	23	4
Bacterial exopeptidase dimerisation domain	Zn-dependent exopeptidases	23	4
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	23	4
Homeodomain-like	Bet v1-like	23	6
EF-hand	Riboflavin synthase domain-like	22	2
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	22	5
Thioredoxin-like	Thioredoxin-like	22	12
CBS-domain pair	CBS-domain pair	22	8
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	22	10
GroEL equatorial domain-like	GroEL-intermediate domain like	22	5
Ankyrin repeat	Ankyrin repeat	22	5
PAZ domain	Ribonuclease H-like	22	4
GroEL-intermediate domain like	GroEL apical domain-like	22	5
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	22	7
GroES-like	GroES-like	22	2
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	22	5
Ribonuclease H-like	DNA/RNA polymerases	22	4
Amine oxidase N-terminal region	Amine oxidase catalytic domain	21	3
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	21	9
Subtilisin-like	PA domain	21	4
Ankyrin repeat	P-loop containing nucleoside triphosphate hydrolases	21	4
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	21	8
FKBP-like	FKBP-like	21	8
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	21	6
dsRNA-binding domain-like	dsRNA-binding domain-like	21	9
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	21	5
E set domains	Ankyrin repeat	21	2
Translation proteins	EF-G C-terminal domain-like	20	7
Bet v1-like	Bet v1-like	20	6
Double Clp-N motif	P-loop containing nucleoside triphosphate hydrolases	20	8
SNARE-like	SNARE fusion complex	20	2
EF-G C-terminal domain-like	EF-G C-terminal domain-like	20	7
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheY-like	20	6
ARM repeat	Protein kinase-like (PK-like)	20	17
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	20	7
EF-hand	P-loop containing nucleoside triphosphate hydrolases	20	5
Amine oxidase N-terminal region	Amine oxidase N-terminal region	20	3
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	20	1
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	20	1
Homodimeric domain of signal transducing histidine kinase	CheY-like	20	6
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	20	8
Homeodomain-like	"Winged helix" DNA-binding domain	20	2
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	20	3
Cullin repeat-like	Cullin homology domain	19	4
Zinc hairpin stack	RING/U-box	19	5
WD40 repeat-like	WD40 repeat-like	19	11
FKBP-like	TPR-like	19	4
CHY zinc finger-like	Zinc hairpin stack	18	4
Protein kinase-like (PK-like)	RING/U-box	18	6
Chromo domain-like	Chromo domain-like	18	3
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	18	3
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	18	7
CHY zinc finger-like	RING/U-box	18	4
TRAF domain-like	Ubiquitin-like	18	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	18	11
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	18	13
FYVE/PHD zinc finger	RING/U-box	18	9
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	18	3
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	17	6
C2 domain (Calcium/lipid-binding domain, CaLB)	Phospholipase D/nuclease	17	4
ARM repeat	Hect, E3 ligase catalytic domain	17	4
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	17	11
PK beta-barrel domain-like	PK C-terminal domain-like	17	2
EF-hand	Ferredoxin reductase-like, C-terminal NADP-linked domain	17	1
P-loop containing nucleoside triphosphate hydrolases	RING/U-box	17	5
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	17	5
EGF/Laminin	Protein kinase-like (PK-like)	17	5
F-box domain	Tubby C-terminal domain-like	17	3
Acid proteases	Saposin	17	1
FYVE/PHD zinc finger	SET domain	17	10
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	17	2
FAS1 domain	FAS1 domain	16	3
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	16	5
TPR-like	HCP-like	16	12
TATA-box binding protein-like	TATA-box binding protein-like	16	2
Cullin repeat-like	"Winged helix" DNA-binding domain	16	2
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	16	9
YhbY-like	YhbY-like	16	6
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	16	4
Starch-binding domain-like	Galactose-binding domain-like	16	3
P-loop containing nucleoside triphosphate hydrolases	dsRNA-binding domain-like	15	5
TPR-like	Protein kinase-like (PK-like)	15	3
Nucleic acid-binding proteins	Translation proteins SH3-like domain	15	4
Arabinanase/levansucrase/invertase	Concanavalin A-like lectins/glucanases	15	2
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	15	3
Protein kinase-like (PK-like)	WD40 repeat-like	15	4
UDP-Glycosyltransferase/glycogen phosphorylase	HAD-like	15	3
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	15	2
Galactose mutarotase-like	(Trans)glycosidases	15	3
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	15	9
EF-hand	EF-hand	15	7
Translation proteins	Ribosomal protein S5 domain 2-like	15	4
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	15	3
RING/U-box	Ankyrin repeat	15	5
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	14	7
HCP-like	HCP-like	14	7
PA domain	Zn-dependent exopeptidases	14	3
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	14	3
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	14	10
Homeodomain-like	FAD/NAD(P)-binding domain	14	2
Galactose mutarotase-like	Glycosyl hydrolase domain	14	2
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	14	3
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	14	9
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	14	2
Homeodomain-like	FAD-linked reductases, C-terminal domain	14	2
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	14	7
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	14	10
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	14	6
NTF2-like	RNA-binding domain, RBD	14	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	14	6
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	14	4
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	14	2
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	13	3
Protease propeptides/inhibitors	Subtilisin-like	13	3
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	13	2
Ubiquitin-like	UBA-like	13	6
Toll/Interleukin receptor TIR domain	RNI-like	13	9
ARM repeat	WD40 repeat-like	13	10
Carbamate kinase-like	ACT-like	13	4
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	13	5
F-box domain	F-box domain	13	7
Tropomyosin	Tropomyosin	13	4
(Trans)glycosidases	Ricin B-like lectins	13	3
E set domains	(Trans)glycosidases	13	6
RING/U-box	TRAF domain-like	13	3
PGBD-like	Metalloproteases ("zincins"), catalytic domain	13	2
Calponin-homology domain, CH-domain	P-loop containing nucleoside triphosphate hydrolases	13	2
EF-hand	PLC-like phosphodiesterases	12	3
PYP-like sensor domain (PAS domain)	Protein kinase-like (PK-like)	12	3
Protein kinase-like (PK-like)	Ankyrin repeat	12	3
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	12	7
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	12	2
POZ domain	Ankyrin repeat	12	4
HMA, heavy metal-associated domain	HAD-like	12	9
ClpP/crotonase	ClpP/crotonase	12	5
Trypsin-like serine proteases	PDZ domain-like	12	5
MFS general substrate transporter	MFS general substrate transporter	12	2
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	12	4
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	11	4
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	11	5
RNase III domain-like	dsRNA-binding domain-like	11	6
E set domains	Glycosyl hydrolase domain	11	5
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	11	3
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	11	5
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	11	1
Flavoproteins	Riboflavin synthase domain-like	11	3
Class II aaRS and biotin synthetases	GAD domain-like	11	3
BAR/IMD domain-like	SH3-domain	11	1
GAF domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	11	4
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	11	2
HAD-like	BRCT domain	11	3
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	11	1
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	11	5
C2 domain (Calcium/lipid-binding domain, CaLB)	EF-hand	11	2
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	11	4
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	11	1
Quinoprotein alcohol dehydrogenase-like	WD40 repeat-like	11	10
t-snare proteins	SNARE fusion complex	10	3
BRCT domain	BRCT domain	10	8
RCC1/BLIP-II	RCC1/BLIP-II	10	4
vWA-like	Helical domain of Sec23/24	10	4
TPR-like	Chaperone J-domain	10	4
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	10	3
RING/U-box	WD40 repeat-like	10	6
POZ domain	TRAF domain-like	10	2
ARM repeat	Sec7 domain	10	5
beta-sandwich domain of Sec23/24	Zn-finger domain of Sec23/24	10	4
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	10	4
Zn-finger domain of Sec23/24	vWA-like	10	4
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	10	4
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	10	5
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	10	4
Tudor/PWWP/MBT	FYVE/PHD zinc finger	10	5
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	10	5
Homeodomain-like	RING/U-box	10	3
Galactose mutarotase-like	Galactose-binding domain-like	10	3
Sec63 N-terminal domain-like	E set domains	10	4
beta-sandwich domain of Sec23/24	vWA-like	10	4
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	10	2
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	10	5
PH domain-like	Oxysterol-binding protein-like	10	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Formin homology 2 domain (FH2 domain)	9	2
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	9	3
RING/U-box	Cysteine proteinases	9	5
ARM repeat	P-loop containing nucleoside triphosphate hydrolases	9	5
ARID-like	FYVE/PHD zinc finger	9	3
Sigma3 and sigma4 domains of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	9	3
Galactose mutarotase-like	Starch-binding domain-like	9	2
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	9	3
Tudor/PWWP/MBT	SET domain	9	4
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	9	1
(Phosphotyrosine protein) phosphatases II	Formin homology 2 domain (FH2 domain)	9	2
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	9	5
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	9	4
ARM repeat	POZ domain	9	4
Cysteine proteinases	UBA-like	9	3
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	9	7
Homeodomain-like	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	9	2
Galactose oxidase, central domain	E set domains	9	2
E set domains	CBS-domain pair	9	2
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	9	3
RmlC-like cupins	RmlC-like cupins	9	2
HD-domain/PDEase-like	Nucleotidyltransferase	9	6
UBA-like	UBA-like	9	7
PreATP-grasp domain	Rudiment single hybrid motif	9	5
"Winged helix" DNA-binding domain	RNI-like	9	6
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	9	5
CCCH zinc finger	RNA-binding domain, RBD	9	4
ISP domain	Bet v1-like	9	3
Chromo domain-like	S-adenosyl-L-methionine-dependent methyltransferases	9	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	9	3
WW domain	WW domain	9	5
Sigma2 domain of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	9	3
RuBisCO, large subunit, small (N-terminal) domain	RuBisCo, C-terminal domain	9	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	9	4
RNase III domain-like	RNase III domain-like	9	6
Nucleotidylyl transferase	Nucleotidylyl transferase	8	1
Nucleic acid-binding proteins	GAD domain-like	8	2
HIT/MYND zinc finger-like	Cysteine proteinases	8	1
NAD(P)-binding Rossmann-fold domains	ACT-like	8	4
SET domain	RuBisCo LSMT C-terminal, substrate-binding domain	8	3
CAD & PB1 domains	Protein kinase-like (PK-like)	8	1
E set domains	AMPKBI-like	8	2
ADC-like	Cdc48 domain 2-like	8	4
Cysteine proteinases	DUSP-like	8	3
LysM domain	Protein kinase-like (PK-like)	8	2
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	8	4
Adenine nucleotide alpha hydrolases-like	RING/U-box	8	1
Translation proteins	Initiation factor IF2/eIF5b, domain 3	8	4
CheY-like	CheY-like	8	1
L domain-like	Formin homology 2 domain (FH2 domain)	8	2
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	8	4
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	8	4
Single hybrid motif	CoA-dependent acyltransferases	8	4
FAD-linked reductases, C-terminal domain	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	8	1
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	8	1
(Trans)glycosidases	Chitinase insertion domain	8	4
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	8	3
Zinc beta-ribbon	Cyclin-like	8	2
Protein kinase-like (PK-like)	Formin homology 2 domain (FH2 domain)	8	2
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	8	2
P-loop containing nucleoside triphosphate hydrolases	DNA-binding pseudobarrel domain	8	6
POZ domain	POZ domain	8	6
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	8	3
Actin-crosslinking proteins	(Trans)glycosidases	8	1
Voltage-gated potassium channels	EF-hand	8	3
Actin depolymerizing proteins	Actin depolymerizing proteins	8	4
Cysteine proteinases	Granulin repeat	8	2
FAD/NAD(P)-binding domain	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	8	1
P-loop containing nucleoside triphosphate hydrolases	CYTH-like phosphatases	8	3
GAF domain-like	Homodimeric domain of signal transducing histidine kinase	7	4
Carbamate kinase-like	ALDH-like	7	1
Ubiquitin-like	BAG domain	7	3
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	7	2
EF-hand	Mitochondrial carrier	7	2
TPR-like	Thioredoxin-like	7	4
TAZ domain	FYVE/PHD zinc finger	7	3
ArfGap/RecO-like zinc finger	C2 domain (Calcium/lipid-binding domain, CaLB)	7	3
POZ domain	TAZ domain	7	2
F-box domain	HCP-like	7	3
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	7	2
PAZ domain	RNase III domain-like	7	5
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	7	2
PH domain-like	FYVE/PHD zinc finger	7	2
P-loop containing nucleoside triphosphate hydrolases	RNase III domain-like	7	5
P-loop containing nucleoside triphosphate hydrolases	UBA-like	7	5
(Phosphotyrosine protein) phosphatases II	DNA ligase/mRNA capping enzyme, catalytic domain	7	4
RCC1/BLIP-II	FYVE/PHD zinc finger	7	2
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	7	2
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	7	4
PDZ domain-like	ClpP/crotonase	7	1
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	7	1
TPR-like	CAD & PB1 domains	7	2
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	7	3
TAZ domain	RING/U-box	7	3
Voltage-gated potassium channels	TrkA C-terminal domain-like	7	1
RING/U-box	RNA-binding domain, RBD	7	1
Dihydrofolate reductase-like	Thymidylate synthase/dCMP hydroxymethylase	7	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	7	3
"Winged helix" DNA-binding domain	E set domains	7	3
Aconitase iron-sulfur domain	LeuD/IlvD-like	7	4
Surp module (SWAP domain)	Ubiquitin-like	7	1
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	7	4
Galactose-binding domain-like	NAD(P)-binding Rossmann-fold domains	7	2
L domain-like	Actin-like ATPase domain	7	6
PH domain-like	P-loop containing nucleoside triphosphate hydrolases	7	3
"Winged helix" DNA-binding domain	Actin-like ATPase domain	7	6
RNA-binding domain, RBD	PABC (PABP) domain	7	3
P-loop containing nucleoside triphosphate hydrolases	Actin-like ATPase domain	7	6
DNase I-like	EF-hand	7	4
PH domain-like	Bet v1-like	7	2
Enolase N-terminal domain-like	Enolase C-terminal domain-like	7	3
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	7	2
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	7	1
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	7	2
PurM N-terminal domain-like	PurM C-terminal domain-like	7	4
Class II aaRS ABD-related	C-terminal domain of ProRS	7	2
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	7	2
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	7	4
Periplasmic binding protein-like II	ACT-like	7	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	7	2
TRAF domain-like	Cysteine proteinases	7	2
P-loop containing nucleoside triphosphate hydrolases	PAZ domain	7	5
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	7	2
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	7	2
Nucleoside hydrolase	Nucleoside hydrolase	7	3
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	7	4
ARID-like	HMG-box	7	4
ENT-like	Tudor/PWWP/MBT	7	2
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	7	3
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	7	3
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	7	2
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	7	2
RCC1/BLIP-II	Protein kinase-like (PK-like)	7	4
SAP domain	FYVE/PHD zinc finger	6	2
SMAD/FHA domain	P-loop containing nucleoside triphosphate hydrolases	6	1
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	6	1
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	6	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	6	4
ADC-like	P-loop containing nucleoside triphosphate hydrolases	6	2
BAR/IMD domain-like	PH domain-like	6	4
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	6	4
Trypsin-like serine proteases	Trypsin-like serine proteases	6	5
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	6	2
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	6	3
RING/U-box	PUA domain-like	6	3
TPR-like	RING/U-box	6	3
Cap-Gly domain	Ubiquitin-like	6	2
GroEL apical domain-like	SAICAR synthase-like	6	3
PH domain-like	RCC1/BLIP-II	6	1
FYVE/PHD zinc finger	Plus3-like	6	3
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	6	2
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	6	3
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	6	4
Carbamate kinase-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	6	2
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	6	3
SWIB/MDM2 domain	Plus3-like	6	3
Ubiquitin-like	Zn-binding ribosomal proteins	6	1
Retrovirus zinc finger-like domains	RING/U-box	6	1
Oxidoreductase molybdopterin-binding domain	E set domains	6	3
LEA14-like	LEA14-like	6	2
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	6	3
Thioredoxin-like	Cysteine-rich domain	6	2
MOSC N-terminal domain-like	PK beta-barrel domain-like	6	1
FAD/NAD(P)-binding domain	EF-hand	6	2
C2 domain (Calcium/lipid-binding domain, CaLB)	vWA-like	6	2
Plant lectins/antimicrobial peptides	Lysozyme-like	6	2
ARM repeat	Clathrin adaptor appendage domain	6	4
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	6	2
Voltage-gated potassium channels	Voltage-gated potassium channels	6	3
GST C-terminal domain-like	eEF-1beta-like	6	3
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	6	2
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	6	2
Cysteine proteinases	Sec-C motif	6	1
Tetrahydrobiopterin biosynthesis enzymes-like	Tetrahydrobiopterin biosynthesis enzymes-like	6	2
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	6	3
(Trans)glycosidases	(Trans)glycosidases	6	3
ACT-like	Formyltransferase	6	1
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	6	2
(Phosphotyrosine protein) phosphatases II	Nucleic acid-binding proteins	6	3
(Trans)glycosidases	Protein kinase-like (PK-like)	6	3
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	6	4
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	6	1
Carbamate kinase-like	NAD(P)-binding Rossmann-fold domains	6	2
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	6	1
Translational machinery components	L30e-like	6	3
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	6	1
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	6	1
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	6	1
CBS-domain pair	CAD & PB1 domains	6	2
POZ domain	TPR-like	6	4
FYVE/PHD zinc finger	Homeodomain-like	6	2
PH domain-like	ArfGap/RecO-like zinc finger	6	4
Ribonuclease H-like	HRDC-like	6	2
Translation proteins	ThrRS/AlaRS common domain	6	2
PriA/YqbF domain	GINS helical bundle-like	6	2
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	6	2
Ubiquitin-like	Protein kinase-like (PK-like)	6	1
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	6	4
ACT-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	6	2
Actin depolymerizing proteins	VHP, Villin headpiece domain	6	2
Toll/Interleukin receptor TIR domain	Actin-like ATPase domain	6	5
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	6	1
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	6	2
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	5	2
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	5	2
BEACH domain	WD40 repeat-like	5	4
Ribulose-phoshate binding barrel	Ribulose-phoshate binding barrel	5	2
Ricin B-like lectins	Glycosyl hydrolase domain	5	1
Protein kinase-like (PK-like)	KA1-like	5	1
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	5	1
UBC-like	UBA-like	5	1
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	5	2
GST C-terminal domain-like	eEF1-gamma domain	5	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	5	1
Metallo-hydrolase/oxidoreductase	DNA ligase/mRNA capping enzyme, catalytic domain	5	3
FYVE/PHD zinc finger	SWIB/MDM2 domain	5	2
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	5	3
Adenine nucleotide alpha hydrolases-like	YjgF-like	5	1
CCCH zinc finger	RING/U-box	5	2
PAZ domain	dsRNA-binding domain-like	5	3
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	5	4
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	5	3
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	5	1
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	5	1
C-terminal domain of alpha and beta subunits of F1 ATP synthase	Epsilon subunit of F1F0-ATP synthase N-terminal domain	5	2
Metallo-dependent hydrolases	Glutamine synthetase/guanido kinase	5	1
Protein kinase-like (PK-like)	P-loop containing nucleoside triphosphate hydrolases	5	5
cAMP-binding domain-like	Ankyrin repeat	5	1
PH domain-like	Ankyrin repeat	5	3
RING/U-box	UBA-like	5	2
ArfGap/RecO-like zinc finger	Ankyrin repeat	5	3
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	5	2
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	5	1
Class II aaRS and biotin synthetases	Translation proteins	5	1
Class I glutamine amidotransferase-like	Class I glutamine amidotransferase-like	5	2
TPR-like	"Winged helix" DNA-binding domain	5	2
YjgF-like	YjgF-like	5	1
Voltage-gated potassium channels	Ankyrin repeat	5	1
P-loop containing nucleoside triphosphate hydrolases	Macro domain-like	5	3
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	5	2
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	5	3
PLC-like phosphodiesterases	PLC-like phosphodiesterases	5	3
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	5	2
SWIB/MDM2 domain	SWIB/MDM2 domain	5	2
BAR/IMD domain-like	Ankyrin repeat	5	3
HCP-like	HIT/MYND zinc finger-like	5	2
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	5	3
PYP-like sensor domain (PAS domain)	GAF domain-like	5	1
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	5	2
Kelch motif	Kelch motif	5	3
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	5	3
PWI domain	RNA-binding domain, RBD	5	2
alpha-D-mannose-specific plant lectins	alpha-D-mannose-specific plant lectins	5	3
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	5	4
Thioredoxin-like	eEF1-gamma domain	5	1
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	5	2
Metallo-dependent hydrolases	Glutamine synthetase, N-terminal domain	5	1
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	5	2
SET domain	TPR-like	5	2
UROD/MetE-like	UROD/MetE-like	5	2
Chaperone J-domain	4Fe-4S ferredoxins	5	3
P-loop containing nucleoside triphosphate hydrolases	Epsilon subunit of F1F0-ATP synthase N-terminal domain	5	2
TRAF domain-like	TRAF domain-like	5	4
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	5	2
Ubiquitin-like	Homeodomain-like	5	1
F-box domain	Actin-like ATPase domain	5	1
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	5	4
Metallo-hydrolase/oxidoreductase	ATP-dependent DNA ligase DNA-binding domain	5	3
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	5	2
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	5	1
GAF domain-like	GAF domain-like	5	1
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	5	4
ARM repeat	Tudor/PWWP/MBT	5	4
SMAD/FHA domain	PP2C-like	5	1
GAF domain-like	CheY-like	5	3
CCCH zinc finger	Eukaryotic type KH-domain (KH-domain type I)	5	3
RING/U-box	BRCT domain	4	2
BRCT domain	FYVE/PHD zinc finger	4	3
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	4	2
P-loop containing nucleoside triphosphate hydrolases	Pre-protein crosslinking domain of SecA	4	4
WD40 repeat-like	DNase I-like	4	2
ARM repeat	Subdomain of clathrin and coatomer appendage domain	4	3
ARM repeat	TPR-like	4	3
TPR-like	HSP20-like chaperones	4	2
PRTase-like	Ribulose-phoshate binding barrel	4	1
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	4	3
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	4	1
Ubiquitin-like	Hect, E3 ligase catalytic domain	4	2
PH domain-like	GTPase activation domain, GAP	4	1
PLP-binding barrel	Alanine racemase C-terminal domain-like	4	2
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	4	2
Glutamyl tRNA-reductase catalytic, N-terminal domain	Glutamyl tRNA-reductase dimerization domain	4	2
P-loop containing nucleoside triphosphate hydrolases	RNA-binding domain, RBD	4	4
Starch-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	4	1
(Phosphotyrosine protein) phosphatases II	NAD kinase/diacylglycerol kinase-like	4	1
Zn-dependent exopeptidases	Transferrin receptor-like dimerisation domain	4	1
FYVE/PHD zinc finger	Transducin (alpha subunit), insertion domain	4	2
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	4	1
E set domains	E set domains	4	2
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	4	3
SBT domain	Ankyrin repeat	4	2
Chitinase insertion domain	Protein kinase-like (PK-like)	4	2
Hypothetical protein SAV1430	Fe-S cluster assembly (FSCA) domain-like	4	1
FYVE/PHD zinc finger	SAICAR synthase-like	4	2
Hairpin loop containing domain-like	Protein kinase-like (PK-like)	4	2
PurM N-terminal domain-like	Class I glutamine amidotransferase-like	4	2
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	4	3
P-loop containing nucleoside triphosphate hydrolases	F-box domain	4	4
Formate/glycerate dehydrogenase catalytic domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	4	1
Chaperone J-domain	CSL zinc finger	4	2
Hemopexin-like domain	Hemopexin-like domain	4	1
tRNA-binding arm	Class II aaRS and biotin synthetases	4	2
Ubiquitin-like	PUG domain-like	4	3
WW domain	P-loop containing nucleoside triphosphate hydrolases	4	1
Putative isomerase YbhE	WD40 repeat-like	4	3
E set domains	RNA-binding domain, RBD	4	1
UBA-like	Hect, E3 ligase catalytic domain	4	2
Clathrin heavy-chain terminal domain	ARM repeat	4	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	4	2
ARID-like	Clavaminate synthase-like	4	2
PH domain-like	Phospholipase D/nuclease	4	2
FF domain	FF domain	4	3
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	4	3
MIT domain	P-loop containing nucleoside triphosphate hydrolases	4	1
ARM repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	4	4
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	4	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	Epsilon subunit of F1F0-ATP synthase N-terminal domain	4	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	4	2
Glutamyl tRNA-reductase catalytic, N-terminal domain	NAD(P)-binding Rossmann-fold domains	4	2
Thioredoxin-like	"Winged helix" DNA-binding domain	4	1
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	4	2
alpha/beta-Hydrolases	alpha/beta-Hydrolases	4	3
Quinoprotein alcohol dehydrogenase-like	3-carboxy-cis,cis-mucoante lactonizing enzyme	4	3
FYVE/PHD zinc finger	GYF domain	4	2
Globin-like	Globin-like	4	1
ClpP/crotonase	6-phosphogluconate dehydrogenase C-terminal domain-like	4	2
FYVE/PHD zinc finger	Clavaminate synthase-like	4	2
NAD(P)-binding Rossmann-fold domains	Glutamyl tRNA-reductase dimerization domain	4	2
Cyclophilin-like	TPR-like	4	1
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	4	3
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	4	2
ARM repeat	UBA-like	4	2
alpha-D-mannose-specific plant lectins	Hairpin loop containing domain-like	4	2
FYVE/PHD zinc finger	GroEL apical domain-like	4	2
Kelch motif	Metallo-dependent phosphatases	4	2
USP8 N-terminal domain-like	JAB1/MPN domain	4	2
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	4	1
CCCH zinc finger	HIT-like	4	1
PH domain-like	WD40 repeat-like	4	3
Protein kinase-like (PK-like)	PH domain-like	4	2
vWA-like	Cysteine-rich domain	4	1
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	4	2
WW domain	FF domain	4	3
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	4	1
PRTase-like	PRTase-like	4	2
Cysteine proteinases	Ubiquitin-like	4	2
Arp2/3 complex subunits	Arp2/3 complex subunits	4	1
SNARE fusion complex	SNARE fusion complex	4	2
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	4	2
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	4	2
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	4	3
PP2C-like	Protein kinase-like (PK-like)	4	4
PH domain-like	ARM repeat	4	3
PA domain	Transferrin receptor-like dimerisation domain	4	1
FYVE/PHD zinc finger	Ankyrin repeat	4	1
YrdC/RibB	RibA-like	4	2
P-loop containing nucleoside triphosphate hydrolases	TGS-like	4	2
F-box domain	WD40 repeat-like	4	3
Starch-binding domain-like	Phosphoglycerate mutase-like	4	1
PurM C-terminal domain-like	Class I glutamine amidotransferase-like	4	2
Putative DNA-binding domain	Class II aaRS and biotin synthetases	4	2
F-box domain	HIT/MYND zinc finger-like	4	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	4	2
Putative DNA-binding domain	Putative DNA-binding domain	4	2
PH domain-like	BEACH domain	4	3
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	3	1
P-loop containing nucleoside triphosphate hydrolases	Elongation factor Ts (EF-Ts), dimerisation domain	3	3
Elongation factor Ts (EF-Ts), dimerisation domain	Elongation factor Ts (EF-Ts), dimerisation domain	3	3
P-loop containing nucleoside triphosphate hydrolases	RecA protein, C-terminal domain	3	2
PUA domain-like	alpha/beta knot	3	1
TPR-like	PUA domain-like	3	1
Oxidoreductase molybdopterin-binding domain	Riboflavin synthase domain-like	3	2
DNA-binding domain	DNA-binding pseudobarrel domain	3	3
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	3	2
Second domain of FERM	P-loop containing nucleoside triphosphate hydrolases	3	2
MoeA N-terminal region -like	Molybdenum cofactor biosynthesis proteins	3	3
Translation proteins	Translation proteins	3	1
Alpha-L RNA-binding motif	Pseudouridine synthase	3	1
Osmotin, thaumatin-like protein	Protein kinase-like (PK-like)	3	2
RNA-binding domain, RBD	DNase I-like	3	2
F-box domain	Protein kinase-like (PK-like)	3	2
BRCA2 helical domain	BRCA2 tower domain	3	3
Ribosomal proteins S24e, L23 and L15e	Nucleic acid-binding proteins	3	2
PLP-dependent transferases	Ornithine decarboxylase C-terminal domain	3	1
Chaperone J-domain	E set domains	3	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	3	1
Osmotin, thaumatin-like protein	alpha-D-mannose-specific plant lectins	3	2
"Winged helix" DNA-binding domain	Elongation factor Ts (EF-Ts), dimerisation domain	3	3
P-loop containing nucleoside triphosphate hydrolases	vWA-like	3	2
Concanavalin A-like lectins/glucanases	BEACH domain	3	2
PheT/TilS domain	Class II aaRS and biotin synthetases	3	1
Nucleic acid-binding proteins	BRCA2 tower domain	3	3
Tricorn protease N-terminal domain	DPP6 N-terminal domain-like	3	1
Cation efflux protein cytoplasmic domain-like	Cation efflux protein cytoplasmic domain-like	3	2
Bacterial photosystem II reaction centre, L and M subunits	Photosystem II antenna protein-like	3	1
WGR domain-like	Domain of poly(ADP-ribose) polymerase	3	3
WD40 repeat-like	DPP6 N-terminal domain-like	3	2
UDP-Glycosyltransferase/glycogen phosphorylase	L domain-like	3	3
Heme oxygenase-like	HAD-like	3	2
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	3	2
PurM C-terminal domain-like	PurM C-terminal domain-like	3	1
Ribosomal L27 protein-like	Nucleic acid-binding proteins	3	2
PurM N-terminal domain-like	PurM N-terminal domain-like	3	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	3	2
HMA, heavy metal-associated domain	"Winged helix" DNA-binding domain	3	2
FGAM synthase PurL, linker domain	PurM N-terminal domain-like	3	1
Metalloproteases ("zincins"), catalytic domain	HAD-like	3	1
PAH2 domain	F-box domain	3	1
Actin-crosslinking proteins	Actin-crosslinking proteins	3	1
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	3	3
LysM domain	LysM domain	3	1
HisI-like	all-alpha NTP pyrophosphatases	3	2
Cytochrome f, large domain	Rudiment single hybrid motif	3	2
Cyclophilin-like	RNA-binding domain, RBD	3	1
GroEL-intermediate domain like	GroEL-intermediate domain like	3	2
Ribosomal protein S5 domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	3	2
Fe-S cluster assembly (FSCA) domain-like	Fe-S cluster assembly (FSCA) domain-like	3	1
Undecaprenyl diphosphate synthase	Undecaprenyl diphosphate synthase	3	1
Scorpion toxin-like	Scorpion toxin-like	3	2
PapD-like	Ankyrin repeat	3	3
DEK C-terminal domain	ssDNA-binding transcriptional regulator domain	3	1
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	3	2
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	3	2
SufE/NifU	BolA-like	3	1
BRCT domain	DNA/RNA polymerases	3	1
PUA domain-like	P-loop containing nucleoside triphosphate hydrolases	3	2
Cystatin/monellin	Cystatin/monellin	3	3
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	3	1
PH domain-like	HMG-box	3	1
AN1-like Zinc finger	AN1-like Zinc finger	3	2
Phage tail proteins	Phage tail proteins	3	3
MoeA N-terminal region -like	MoeA C-terminal domain-like	3	3
Metallo-hydrolase/oxidoreductase	Nucleic acid-binding proteins	3	1
UDP-Glycosyltransferase/glycogen phosphorylase	P-loop containing nucleoside triphosphate hydrolases	3	3
FGAM synthase PurL, linker domain	PurM C-terminal domain-like	3	1
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	3	3
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	3	2
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	3	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Nucleic acid-binding proteins	3	2
(Phosphotyrosine protein) phosphatases II	Actin depolymerizing proteins	3	2
POZ domain	RNI-like	3	2
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	3	2
HAD-like	Glycerol-3-phosphate (1)-acyltransferase	3	1
PurS-like	FGAM synthase PurL, linker domain	3	1
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	3	1
HAD-like	Thioredoxin-like	3	1
E set domains	Riboflavin synthase domain-like	3	2
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	3	2
HAD-like	NTF2-like	3	1
DUSP-like	Ubiquitin-like	3	1
Saposin	Saposin	3	2
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	3	3
E set domains	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
Oxidoreductase molybdopterin-binding domain	Cytochrome b5-like heme/steroid binding domain	3	2
PreATP-grasp domain	Single hybrid motif	3	3
Flavoproteins	Protein kinase-like (PK-like)	3	1
Quinoprotein alcohol dehydrogenase-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	3	3
Chaperone J-domain	Thioredoxin-like	3	2
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	3	3
Translational machinery components	RBP11-like subunits of RNA polymerase	3	2
Translational machinery components	Insert subdomain of RNA polymerase alpha subunit	3	2
Voltage-gated potassium channels	Glycosyl hydrolase domain	3	3
Amidase signature (AS) enzymes	TPR-like	3	1
Cytochrome b5-like heme/steroid binding domain	Riboflavin synthase domain-like	3	2
Pre-protein crosslinking domain of SecA	Helical scaffold and wing domains of SecA	3	3
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	3	2
E set domains	Cytochrome b5-like heme/steroid binding domain	3	2
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	3	2
Ribonuclease PH domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	3	2
Ubiquitin-like	XPC-binding domain	3	2
Concanavalin A-like lectins/glucanases	PH domain-like	3	2
Nucleic acid-binding proteins	eIF2alpha middle domain-like	3	1
Ribosomal protein S5 domain 2-like	Nucleic acid-binding proteins	3	2
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	3	2
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	3	2
beta and beta-prime subunits of DNA dependent RNA-polymerase	beta and beta-prime subunits of DNA dependent RNA-polymerase	3	2
Tropomyosin	Apolipoprotein A-I	3	1
Tudor/PWWP/MBT	RNA-binding domain, RBD	3	1
Heat shock protein 70kD (HSP70), C-terminal subdomain	Heat shock protein 70kD (HSP70), C-terminal subdomain	3	1
Dom34/Pelota N-terminal domain-like	L30e-like	3	1
PurS-like	PurM N-terminal domain-like	3	1
Putative DNA-binding domain	PheT/TilS domain	3	1
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	3	2
Oxidoreductase molybdopterin-binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
Clavaminate synthase-like	Clavaminate synthase-like	3	1
Cytochrome b5-like heme/steroid binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
L domain-like	Elongation factor Ts (EF-Ts), dimerisation domain	3	3
Ribonuclease H-like	Ribonuclease H-like	3	2
WGR domain-like	ADP-ribosylation	3	3
Ribosomal protein L6	Ribosomal protein L6	3	1
HAD-like	Riboflavin kinase-like	3	1
Concanavalin A-like lectins/glucanases	WD40 repeat-like	3	2
BRCT domain	Lesion bypass DNA polymerase (Y-family), little finger domain	3	1
PRP4-like	WD40 repeat-like	3	2
Thioredoxin-like	NHL repeat	3	1
UDP-Glycosyltransferase/glycogen phosphorylase	Toll/Interleukin receptor TIR domain	3	3
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	3	2
PurS-like	Class I glutamine amidotransferase-like	3	1
Protein kinase-like (PK-like)	(Phosphotyrosine protein) phosphatases II	3	1
RNI-like	ARM repeat	3	1
Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	3	2
UBA-like	XPC-binding domain	3	2
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	3	2
Ubiquitin-like	TPR-like	3	1
Second domain of FERM	PH domain-like	3	2
Eukaryotic type KH-domain (KH-domain type I)	LigT-like	3	2
WWE domain	ADP-ribosylation	3	2
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	3	2
Thioredoxin-like	Ubiquitin-like	3	1
FGAM synthase PurL, linker domain	Class I glutamine amidotransferase-like	3	1
Chaperone J-domain	Sec63 N-terminal domain-like	3	1
HAD-like	NHL repeat	3	1
PreATP-grasp domain	PreATP-grasp domain	3	3
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	3	1
Cytidine deaminase-like	Dihydrofolate reductase-like	3	2
Rudiment single hybrid motif	Single hybrid motif	3	3
Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	3	1
Macro domain-like	CRAL/TRIO domain	3	1
Nucleotidylyl transferase	Ribosomal protein L25-like	3	2
Histone-fold	ARM repeat	3	2
Cullin repeat-like	Cullin repeat-like	3	3
Folate-binding domain	Aminomethyltransferase beta-barrel domain	3	2
Chaperone J-domain	RNA-binding domain, RBD	3	2
PurS-like	PurM C-terminal domain-like	3	1
BRCA2 helical domain	Nucleic acid-binding proteins	3	3
HIT-like	HIT-like	3	2
PUA domain-like	Ribosomal protein S5 domain 2-like	3	2
L domain-like	Outer arm dynein light chain 1	3	3
Class II aaRS and biotin synthetases	HD-domain/PDEase-like	3	3
DNase I-like	DNase I-like	3	2
Dom34/Pelota N-terminal domain-like	Translational machinery components	3	1
HLH, helix-loop-helix DNA-binding domain	ACT-like	3	2
P-loop containing nucleoside triphosphate hydrolases	Helical scaffold and wing domains of SecA	3	3
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	3	1
Rudiment single hybrid motif	Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor	2	1
FAD/NAD(P)-binding domain	HI0933 insert domain-like	2	1
FAD/NAD(P)-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	2	1
FYVE/PHD zinc finger	CCCH zinc finger	2	1
RNA-binding domain, RBD	Clavaminate synthase-like	2	1
ACP-like	Trimeric LpxA-like enzymes	2	2
Aldolase	Aminoacid dehydrogenase-like, N-terminal domain	2	1
F-box domain	Clavaminate synthase-like	2	2
Cytochrome P450	Cytochrome P450	2	1
gp5 N-terminal domain-like	Phage fibre proteins	2	2
Glycerol-3-phosphate (1)-acyltransferase	EF-hand	2	1
Pentein	Pentein	2	1
PGBD-like	DnaJ/Hsp40 cysteine-rich domain	2	1
SMAD/FHA domain	Phospholipase D/nuclease	2	2
YjeF N-terminal domain-like	FMN-binding split barrel	2	1
GYF domain	SET domain	2	1
Formyltransferase	FMT C-terminal domain-like	2	1
Methylglyoxal synthase-like	Cytidine deaminase-like	2	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	2	1
Thiamin diphosphate-binding fold (THDP-binding)	Enolase N-terminal domain-like	2	1
Nitrite and sulphite reductase 4Fe-4S domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	2	2
DHS-like NAD/FAD-binding domain	alpha/beta-Hydrolases	2	1
BRCT domain	ADP-ribosylation	2	2
F-box domain	SMI1/KNR4-like	2	2
Concanavalin A-like lectins/glucanases	HSP20-like chaperones	2	2
Translation proteins SH3-like domain	Ribosomal protein S19	2	1
Barwin-like endoglucanases	Protein kinase-like (PK-like)	2	1
vWA-like	SPOC domain-like	2	2
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	2	2
HMA, heavy metal-associated domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	2	1
PUA domain-like	Nucleotidylyl transferase	2	1
Dcp2 domain-like	Nudix	2	1
SAP domain	RNA-binding domain, RBD	2	1
Nucleic acid-binding proteins	S15/NS1 RNA-binding domain	2	1
RuvA domain 2-like	RuvA domain 2-like	2	2
Actin-like ATPase domain	AF1104-like	2	1
ATP-dependent DNA ligase DNA-binding domain	BRCT domain	2	1
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	2	1
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	2	2
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	2	2
ARID-like	HSP20-like chaperones	2	1
Cysteine-rich domain	Cysteine-rich domain	2	2
RING/U-box	Ran binding protein zinc finger-like	2	1
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	2	1
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	2	1
L domain-like	Leucine zipper domain	2	1
P-loop containing nucleoside triphosphate hydrolases	alpha/beta-Hydrolases	2	2
Phage tail proteins	Phage fibre proteins	2	2
Transmembrane di-heme cytochromes	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	2	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	2	1
Voltage-gated potassium channels	NAD(P)-binding Rossmann-fold domains	2	1
HIT/MYND zinc finger-like	HIT/MYND zinc finger-like	2	1
Protein kinase-like (PK-like)	HSP20-like chaperones	2	2
HD-domain/PDEase-like	TGS-like	2	2
Urease, beta-subunit	Metallo-dependent hydrolases	2	2
GST C-terminal domain-like	Ypt/Rab-GAP domain of gyp1p	2	1
Urease, gamma-subunit	Urease, beta-subunit	2	2
L domain-like	UBA-like	2	2
Ribonuclease H-like	Nucleic acid-binding proteins	2	2
cAMP-binding domain-like	ALDH-like	2	2
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	2	1
SAND domain-like	SET domain	2	1
P-loop containing nucleoside triphosphate hydrolases	Obg GTP-binding protein C-terminal domain	2	1
Toll/Interleukin receptor TIR domain	UBA-like	2	2
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	2	1
SWIB/MDM2 domain	GYF domain	2	1
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Ribose/Galactose isomerase RpiB/AlsB	RmlC-like cupins	2	1
TRAF domain-like	Kix domain of CBP (creb binding protein)	2	1
Urease, gamma-subunit	Composite domain of metallo-dependent hydrolases	2	2
Riboflavin synthase domain-like	Riboflavin synthase domain-like	2	1
F-box domain	NHL repeat	2	2
FAD/NAD(P)-binding domain	ACP-like	2	2
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	2	1
Toll/Interleukin receptor TIR domain	Elongation factor Ts (EF-Ts), dimerisation domain	2	2
BRCT domain	Domain of poly(ADP-ribose) polymerase	2	2
FAD/NAD(P)-binding domain	Acetyl-CoA synthetase-like	2	2
UraD-Like	Transthyretin (synonym: prealbumin)	2	1
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Cysteine proteinases	Protein kinase-like (PK-like)	2	2
RNA-binding domain, RBD	WW domain	2	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	2	1
FYVE/PHD zinc finger	PUA domain-like	2	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	2	2
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	2	2
Ribosomal proteins S24e, L23 and L15e	YWTD domain	2	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	2	2
HMA, heavy metal-associated domain	L domain-like	2	1
RuvA domain 2-like	Nucleic acid-binding proteins	2	2
NTF2-like	Probable bacterial effector-binding domain	2	1
P-loop containing nucleoside triphosphate hydrolases	FAD/NAD(P)-binding domain	2	1
BRCT domain	WGR domain-like	2	2
Rhomboid-like	UBA-like	2	1
Cullin repeat-like	POZ domain	2	1
TPR-like	Ankyrin repeat	2	2
Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	2	2
Thioredoxin-like	ERP29 C domain-like	2	1
PX domain	BAR/IMD domain-like	2	2
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	2	2
TPR-like	Metallo-dependent phosphatases	2	1
WD40 repeat-like	SNARE fusion complex	2	2
beta-sandwich domain of Sec23/24	Leucine zipper domain	2	1
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	2	1
PDZ domain-like	(Phosphotyrosine protein) phosphatases II	2	2
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	2	1
NAD(P)-binding Rossmann-fold domains	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	2	1
Fe-S cluster assembly (FSCA) domain-like	P-loop containing nucleoside triphosphate hydrolases	2	1
FAD/NAD(P)-binding domain	SMAD/FHA domain	2	1
RING/U-box	Cyclophilin-like	2	1
PsbU/PolX domain-like	Nucleotidyltransferase	2	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	2	1
Tricorn protease domain 2	WD40 repeat-like	2	2
EF-hand	Calponin-homology domain, CH-domain	2	2
Retrovirus zinc finger-like domains	RNA-binding domain, RBD	2	2
WD40 repeat-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	2
Obg GTP-binding protein N-terminal domain	Obg GTP-binding protein C-terminal domain	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	2	2
Aldolase	NAD(P)-binding Rossmann-fold domains	2	1
TAZ domain	TAZ domain	2	1
UBA-like	PUG domain-like	2	2
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Eukaryotic type KH-domain (KH-domain type I)	2	1
Periplasmic binding protein-like II	GlnB-like	2	1
SWIB/MDM2 domain	CCCH zinc finger	2	1
Serine metabolism enzymes domain	ACT-like	2	2
Thiamin diphosphate-binding fold (THDP-binding)	alpha/beta-Hydrolases	2	1
Enolase N-terminal domain-like	alpha/beta-Hydrolases	2	1
HIT/MYND zinc finger-like	RING/U-box	2	1
cAMP-binding domain-like	cAMP-binding domain-like	2	2
Activator of Hsp90 ATPase, Aha1	Bet v1-like	2	1
Enolase C-terminal domain-like	alpha/beta-Hydrolases	2	1
HMG-box	HMG-box	2	2
Clavaminate synthase-like	RING/U-box	2	2
Hypothetical protein c14orf129, hspc210	TPR-like	2	1
Nucleic acid-binding proteins	BRCT domain	2	1
Six-hairpin glycosidases	AbfB domain	2	1
Galactose oxidase, central domain	P-loop containing nucleoside triphosphate hydrolases	2	1
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	2	2
Lipoxigenase	Class II aaRS and biotin synthetases	2	1
Acetyl-CoA synthetase-like	ACP-like	2	2
Class I glutamine amidotransferase-like	Ribulose-phoshate binding barrel	2	1
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
Nucleotidyltransferase	EF-hand	2	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	2	1
Ribosomal protein S2	Nucleotide-diphospho-sugar transferases	2	1
Formate/glycerate dehydrogenase catalytic domain-like	Formate/glycerate dehydrogenase catalytic domain-like	2	1
F-box domain	Acid proteases	2	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	2	1
HCP-like	Homing endonucleases	2	1
FAD/NAD(P)-binding domain	Trimeric LpxA-like enzymes	2	2
Acetyl-CoA synthetase-like	Trimeric LpxA-like enzymes	2	2
Aspartate/glutamate racemase	Aspartate/glutamate racemase	2	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	2	2
P-loop containing nucleoside triphosphate hydrolases	NAD(P)-binding Rossmann-fold domains	2	2
Photosystem I subunits PsaA/PsaB	Photosystem I subunits PsaA/PsaB	2	2
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	2	1
GroEL equatorial domain-like	DNA-binding domain	2	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	Nucleic acid-binding proteins	2	1
PH domain-like	BSD domain-like	2	1
Tex N-terminal region-like	Ribonuclease H-like	2	2
Calcyclin-binding protein-like	HSP20-like chaperones	2	1
Diaminopimelate epimerase-like	Diaminopimelate epimerase-like	2	1
Pseudouridine synthase	Pseudouridine synthase	2	1
ARM repeat	alpha/beta-Hydrolases	2	1
Tricorn protease domain 2	Quinoprotein alcohol dehydrogenase-like	2	2
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	2	2
DHS-like NAD/FAD-binding domain	Enolase N-terminal domain-like	2	1
Nqo1 middle domain-like	Nqo1C-terminal domain-like	2	1
Phage tail proteins	gp5 N-terminal domain-like	2	2
NAD(P)-binding Rossmann-fold domains	Citrate synthase	2	1
HydB/Nqo4-like	4Fe-4S ferredoxins	2	2
Tubulin nucleotide-binding domain-like	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	2	1
NAD(P)-binding Rossmann-fold domains	UDP-Glycosyltransferase/glycogen phosphorylase	2	2
CarD-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Restriction endonuclease-like	RuvA domain 2-like	2	2
Mannose-binding lectins	Mannose-binding lectins	2	1
HD-domain/PDEase-like	EF-hand	2	1
Chaperone J-domain	Homeodomain-like	2	1
Smc hinge domain	Tropomyosin	2	1
Thiamin diphosphate-binding fold (THDP-binding)	Enolase C-terminal domain-like	2	1
Glucocorticoid receptor-like (DNA-binding domain)	HAD-like	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	1
SAP domain	DNase I-like	2	1
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	2	1
WD40 repeat-like	Bromodomain	2	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	2	1
Actin depolymerizing proteins	C-terminal, gelsolin-like domain of Sec23/24	2	1
Histone-fold	NAP-like	2	1
UBC-like	RING/U-box	2	2
Outer arm dynein light chain 1	Protein kinase-like (PK-like)	2	2
PDZ domain-like	TPR-like	2	1
BSD domain-like	BSD domain-like	2	1
Concanavalin A-like lectins/glucanases	RING/U-box	2	1
PP2C-like	cAMP-binding domain-like	2	2
Class I glutamine amidotransferase-like	ADC synthase	2	1
Ran binding protein zinc finger-like	P-loop containing nucleoside triphosphate hydrolases	2	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	2	1
F-box domain	Leucine zipper domain	2	1
Adenine nucleotide alpha hydrolases-like	Thioredoxin-like	2	2
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleic acid-binding proteins	2	1
Cytidine deaminase-like	YbiA-like	2	1
GYF domain	CCCH zinc finger	2	1
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	2	2
Dihydrofolate reductase-like	YbiA-like	2	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
Acyl-CoA binding protein	Kelch motif	2	2
(Phosphotyrosine protein) phosphatases II	E set domains	2	2
P-loop containing nucleoside triphosphate hydrolases	Glucocorticoid receptor-like (DNA-binding domain)	2	2
PDZ domain-like	PDZ domain-like	2	1
BRCT domain	DNA polymerase beta, N-terminal domain-like	2	1
FYVE/PHD zinc finger	SAND domain-like	2	1
"Winged helix" DNA-binding domain	F1F0 ATP synthase subunit A	2	1
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	2	1
Ribonuclease H-like	RuvA domain 2-like	2	2
Clavaminate synthase-like	beta-beta-alpha zinc fingers	2	2
CAD & PB1 domains	RING/U-box	2	1
Chelatase	Chlorophyll a-b binding protein	2	1
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	2	1
Tudor/PWWP/MBT	SAND domain-like	2	1
Single hybrid motif	Single hybrid motif	2	1
C-terminal, gelsolin-like domain of Sec23/24	VHP, Villin headpiece domain	2	1
Thioredoxin-like	Ypt/Rab-GAP domain of gyp1p	2	1
P-loop containing nucleoside triphosphate hydrolases	RuvA domain 2-like	2	1
Heme-dependent peroxidases	Heme-dependent peroxidases	2	1
BRCT domain	PsbU/PolX domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	TRCF domain-like	2	1
TPR-like	RNI-like	2	2
Urease, gamma-subunit	Metallo-dependent hydrolases	2	2
Putative isomerase YbhE	Quinoprotein alcohol dehydrogenase-like	2	1
Ribonuclease H-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
Cullin repeat-like	Skp1 dimerisation domain-like	2	1
ARM repeat	SH3-domain	2	2
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	2	1
HMA, heavy metal-associated domain	Toll/Interleukin receptor TIR domain	2	1
HAD-like	dsRNA-binding domain-like	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	2	1
Ran binding protein zinc finger-like	Translation proteins	2	1
Macro domain-like	Zn-dependent exopeptidases	2	1
Plus3-like	CCCH zinc finger	2	1
cAMP-binding domain-like	Thioesterase/thiol ester dehydrase-isomerase	2	1
Cytochrome f, large domain	Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor	2	1
Nucleotidyltransferase	TGS-like	2	2
cAMP-binding domain-like	Protein kinase-like (PK-like)	2	2
PLP-dependent transferases	PLP-dependent transferases	2	2
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	2	1
FYVE/PHD zinc finger	TPR-like	2	1
CAD & PB1 domains	UBA-like	2	1
RBP11-like subunits of RNA polymerase	C-terminal domain of RNA polymerase alpha subunit	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	2	2
F-box domain	alpha-D-mannose-specific plant lectins	2	1
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	2	1
Plus3-like	GYF domain	2	1
L30e-like	alpha/beta knot	2	1
Ran binding protein zinc finger-like	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	2	1
Insert subdomain of RNA polymerase alpha subunit	C-terminal domain of RNA polymerase alpha subunit	2	1
Ubiquitin-like	L domain-like	2	2
Surp module (SWAP domain)	ENTH/VHS domain	2	2
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	2	2
BRCT domain	Nucleotidyltransferase	2	1
Translational machinery components	C-terminal domain of RNA polymerase alpha subunit	2	1
P-loop containing nucleoside triphosphate hydrolases	D-aminoacid aminotransferase-like PLP-dependent enzymes	2	2
Cytidine deaminase-like	Cytidine deaminase-like	2	1
PYP-like sensor domain (PAS domain)	F-box domain	2	2
BRCT domain	post-AAA+ oligomerization domain-like	2	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	2	2
Probable bacterial effector-binding domain	Probable bacterial effector-binding domain	2	2
Mechanosensitive channel protein MscS (YggB), transmembrane region	Sm-like ribonucleoproteins	2	2
ADP-ribosylation	Hemopexin-like domain	2	2
Ribosomal protein S5 domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
Urease, beta-subunit	Composite domain of metallo-dependent hydrolases	2	2
L domain-like	Cysteine proteinases	2	2
Thioredoxin-like	FAD-dependent thiol oxidase	2	1
CarD-like	TRCF domain-like	2	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	2	1
DHS-like NAD/FAD-binding domain	Enolase C-terminal domain-like	2	1
Protein kinase-like (PK-like)	Class II aaRS and biotin synthetases	1	1
Caspase-like	DNase I-like	1	1
"Winged helix" DNA-binding domain	Periplasmic binding protein-like II	1	1
C-terminal domain of alpha and beta subunits of F1 ATP synthase	Cytochrome c oxidase subunit II-like, transmembrane region	1	1
P-loop containing nucleoside triphosphate hydrolases	Pili subunits	1	1
"Winged helix" DNA-binding domain	Acetyl-CoA synthetase-like	1	1
FAD/NAD(P)-binding domain	Thioredoxin-like	1	1
vWA-like	SAP domain	1	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	1	1
UBC-like	UBC-like	1	1
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	1	1
HydA/Nqo6-like	Nqo5-like	1	1
Cytochrome P450	Calcium-dependent phosphotriesterase	1	1
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	1	1
Tex N-terminal region-like	RuvA domain 2-like	1	1
Protein kinase-like (PK-like)	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
Periplasmic binding protein-like II	MetI-like	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	1	1
ARM repeat	F-box domain	1	1
Ankyrin repeat	S-adenosyl-L-methionine-dependent methyltransferases	1	1
alpha/beta-Hydrolases	Ankyrin repeat	1	1
(Phosphotyrosine protein) phosphatases II	RNA-binding domain, RBD	1	1
Metallo-dependent hydrolases	Metallo-dependent hydrolases	1	1
CoA-dependent acyltransferases	CoA-dependent acyltransferases	1	1
FYVE/PHD zinc finger	Actin-like ATPase domain	1	1
Nucleic acid-binding proteins	RNA-binding domain, RBD	1	1
MurE/MurF N-terminal domain	MurD-like peptide ligases, peptide-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	HAD-like	1	1
F-box domain	SET domain	1	1
WD40 repeat-like	TPR-like	1	1
XRCC4, N-terminal domain	XRCC4, C-terminal oligomerization domain	1	1
Quinoprotein alcohol dehydrogenase-like	DPP6 N-terminal domain-like	1	1
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	1	1
P-loop containing nucleoside triphosphate hydrolases	Typo IV secretion system protein TraC	1	1
Nucleotidylyl transferase	tRNA-binding arm	1	1
Metallo-hydrolase/oxidoreductase	TPR-like	1	1
SAP domain	ADP-ribosylation	1	1
TK C-terminal domain-like	HAD-like	1	1
WD40 repeat-like	Nucleoporin domain	1	1
ARM repeat	Chaperone J-domain	1	1
Kix domain of CBP (creb binding protein)	Protein kinase-like (PK-like)	1	1
ClpP/crotonase	Thiolase-like	1	1
MetI-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Pseudouridine synthase	PUA domain-like	1	1
MFS general substrate transporter	Alkaline phosphatase-like	1	1
ACP-like	Heme-dependent catalase-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	YgbK-like	1	1
ALDH-like	TPR-like	1	1
TAF(II)230 TBP-binding fragment	Ubiquitin-like	1	1
Protein kinase-like (PK-like)	BEACH domain	1	1
Ubiquitin-like	P-loop containing nucleoside triphosphate hydrolases	1	1
FYVE/PHD zinc finger	Bromodomain	1	1
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	1	1
Aldolase	Ribulose-phoshate binding barrel	1	1
Carbohydrate phosphatase	NAD(P)-binding Rossmann-fold domains	1	1
Terpenoid synthases	Outer arm dynein light chain 1	1	1
Thiamin diphosphate-binding fold (THDP-binding)	NAD(P)-binding Rossmann-fold domains	1	1
Ribosomal protein S8	RuBisCo, C-terminal domain	1	1
Single hybrid motif	ClpP/crotonase	1	1
CBS-domain pair	FAD-binding/transporter-associated domain-like	1	1
Ankyrin repeat	DNA/RNA polymerases	1	1
Cysteine proteinases	Thioredoxin-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	Retrovirus zinc finger-like domains	1	1
Ribonuclease H-like	DNase I-like	1	1
lambda repressor-like DNA-binding domains	RmlC-like cupins	1	1
Metallo-dependent phosphatases	Metallo-dependent phosphatases	1	1
Metalloproteases ("zincins"), catalytic domain	ARM repeat	1	1
SSo0622-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
S-adenosyl-L-methionine-dependent methyltransferases	alpha-D-mannose-specific plant lectins	1	1
WD40 repeat-like	P-loop containing nucleoside triphosphate hydrolases	1	1
vWA-like	C-terminal domain of Ku80	1	1
L domain-like	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Photosystem II antenna protein-like	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
GST C-terminal domain-like	Nucleic acid-binding proteins	1	1
Arabinanase/levansucrase/invertase	Nucleotide-diphospho-sugar transferases	1	1
Carbamate kinase-like	Carbamate kinase-like	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	tRNA-binding arm	1	1
P-loop containing nucleoside triphosphate hydrolases	Methyl-accepting chemotaxis protein (MCP) signaling domain	1	1
Trigger factor ribosome-binding domain	Triger factor/SurA peptide-binding domain-like	1	1
PRC-barrel domain	Nucleotide-diphospho-sugar transferases	1	1
Phage fibre proteins	Ankyrin repeat	1	1
Pectin lyase-like	Pectin lyase-like	1	1
Acyl-CoA dehydrogenase C-terminal domain-like	Thioesterase/thiol ester dehydrase-isomerase	1	1
Phage tail proteins	Tricorn protease N-terminal domain	1	1
Leucine zipper domain	Chaperone J-domain	1	1
Terpenoid synthases	Protein kinase-like (PK-like)	1	1
C-type lectin-like	Protein kinase-like (PK-like)	1	1
Poly A polymerase C-terminal region-like	Poly A polymerase C-terminal region-like	1	1
Phosphofructokinase	P-loop containing nucleoside triphosphate hydrolases	1	1
PLP-dependent transferases	(Trans)glycosidases	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FAD/NAD(P)-binding domain	1	1
Concanavalin A-like lectins/glucanases	SH2 domain	1	1
Homeodomain-like	F-box domain	1	1
DNA breaking-rejoining enzymes	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
gp5 N-terminal domain-like	gp5 N-terminal domain-like	1	1
L domain-like	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
NAD(P)-binding Rossmann-fold domains	F-box domain	1	1
Protein kinase-like (PK-like)	HCP-like	1	1
TAF(II)230 TBP-binding fragment	Bromodomain	1	1
F-box domain	Pectin lyase-like	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	RNA-binding domain, RBD	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	Homeodomain-like	1	1
FMN-linked oxidoreductases	FAD/NAD(P)-binding domain	1	1
Alpha subunit of glutamate synthase, C-terminal domain	FAD/NAD(P)-binding domain	1	1
PDZ domain-like	Rubredoxin-like	1	1
FYVE/PHD zinc finger	F-box domain	1	1
Class II aaRS and biotin synthetases	Class II aaRS and biotin synthetases	1	1
Acetyl-CoA synthetase-like	Tetracyclin repressor-like, C-terminal domain	1	1
Phosphofructokinase	NAD(P)-binding Rossmann-fold domains	1	1
Acetyl-CoA synthetase-like	Heme-dependent catalase-like	1	1
Lipoxigenase	Metal cation-transporting ATPase, ATP-binding domain N	1	1
Multidrug resistance efflux transporter EmrE	ENTH/VHS domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	alpha-helical ferredoxin	1	1
DNA-binding pseudobarrel domain	Nucleic acid-binding proteins	1	1
ALDH-like	ALDH-like	1	1
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	1	1
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	1	1
RNA-binding domain, RBD	Surp module (SWAP domain)	1	1
ARM repeat	Acid proteases	1	1
Photosystem II reaction center protein K, PsbK	Photosystem II reaction center protein I, PsbI	1	1
Glutathione synthetase ATP-binding domain-like	Phosphohistidine domain	1	1
PDZ domain-like	E set domains	1	1
Zn-dependent exopeptidases	Protein kinase-like (PK-like)	1	1
Zn-dependent exopeptidases	L domain-like	1	1
Ribonuclease H-like	Alkaline phosphatase-like	1	1
MIT domain	MIT domain	1	1
Starch-binding domain-like	Nucleic acid-binding proteins	1	1
HMA, heavy metal-associated domain	NosL/MerB-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	1	1
lambda repressor-like DNA-binding domains	Cyanase C-terminal domain	1	1
FYSH domain	beta-beta-alpha zinc fingers	1	1
Aquaporin-like	HMA, heavy metal-associated domain	1	1
ISP domain	Chlorophyll a-b binding protein	1	1
L domain-like	RING/U-box	1	1
Translation proteins	PRC-barrel domain	1	1
Bromodomain	Nucleic acid-binding proteins	1	1
Adenine nucleotide alpha hydrolases-like	Molybdenum cofactor biosynthesis proteins	1	1
AF0104/ALDC/Ptd012-like	AF0104/ALDC/Ptd012-like	1	1
alpha/beta knot	Nucleic acid-binding proteins	1	1
N-utilization substance G protein NusG, N-terminal domain	Translation proteins SH3-like domain	1	1
RuvA domain 2-like	SH2 domain	1	1
Ribosomal protein S2	F1F0 ATP synthase subunit A	1	1
Tricorn protease domain 2	alpha/beta-Hydrolases	1	1
Pectin lyase-like	RmlC-like cupins	1	1
Cytochrome b5-like heme/steroid binding domain	alpha/beta-Hydrolases	1	1
WGR domain-like	NAD(P)-binding Rossmann-fold domains	1	1
Staphylococcal nuclease	Tudor/PWWP/MBT	1	1
P-loop containing nucleoside triphosphate hydrolases	Ribonuclease Rh-like	1	1
gp5 N-terminal domain-like	Tricorn protease N-terminal domain	1	1
Protein kinase-like (PK-like)	Metal cation-transporting ATPase, ATP-binding domain N	1	1
Translation proteins	Nucleotide-diphospho-sugar transferases	1	1
Rhodanese/Cell cycle control phosphatase	alpha/beta-Hydrolases	1	1
Kix domain of CBP (creb binding protein)	Kix domain of CBP (creb binding protein)	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	"Winged helix" DNA-binding domain	1	1
D-aminoacid aminotransferase-like PLP-dependent enzymes	D-aminoacid aminotransferase-like PLP-dependent enzymes	1	1
Cysteine proteinases	DNA-binding pseudobarrel domain	1	1
ARM repeat	Concanavalin A-like lectins/glucanases	1	1
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	1	1
ARM repeat	FabD/lysophospholipase-like	1	1
Aldolase	HAD-like	1	1
Leukotriene A4 hydrolase N-terminal domain	ARM repeat	1	1
F-box domain	YWTD domain	1	1
Homeodomain-like	Tetracyclin repressor-like, C-terminal domain	1	1
Glutathione synthetase ATP-binding domain-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
Ribulose-phoshate binding barrel	HAD-like	1	1
FYVE/PHD zinc finger	Chromo domain-like	1	1
Rudiment single hybrid motif	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
Phage tail proteins	alpha/beta-Hydrolases	1	1
SAP domain	WGR domain-like	1	1
AN1-like Zinc finger	beta-beta-alpha zinc fingers	1	1
"Winged helix" DNA-binding domain	GAF domain-like	1	1
Acid proteases	Nucleic acid-binding proteins	1	1
S15/NS1 RNA-binding domain	HydB/Nqo4-like	1	1
ISP transmembrane anchor	ISP domain	1	1
Aquaporin-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleic acid-binding proteins	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Putative isomerase YbhE	RING/U-box	1	1
alpha/beta-Hydrolases	HCP-like	1	1
RNI-like	WD40 repeat-like	1	1
DNA-binding pseudobarrel domain	Ribonuclease H-like	1	1
Tudor/PWWP/MBT	Tudor/PWWP/MBT	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	GHMP Kinase, C-terminal domain	1	1
Oxygen-evolving enhancer protein 3,	Cyclophilin-like	1	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	Cytochrome c oxidase subunit II-like, transmembrane region	1	1
Protein kinase-like (PK-like)	PR-1-like	1	1
FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	1	1
WD40 repeat-like	NHL repeat	1	1
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	1	1
Thiolase-like	WD40 repeat-like	1	1
Metallo-hydrolase/oxidoreductase	Protein kinase-like (PK-like)	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
Acyl-CoA N-acyltransferases (Nat)	BRCT domain	1	1
PA domain	EGF/Laminin	1	1
UBC-like	Class II aaRS and biotin synthetases	1	1
Arabinanase/levansucrase/invertase	Arabinanase/levansucrase/invertase	1	1
Second domain of FERM	Prismane protein-like	1	1
WD40 repeat-like	Peptidase/esterase 'gauge' domain	1	1
Thioredoxin-like	Ribonuclease Rh-like	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	Clavaminate synthase-like	1	1
UBA-like	post-AAA+ oligomerization domain-like	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	1	1
GAF domain-like	Acetyl-CoA synthetase-like	1	1
DEK C-terminal domain	SWIB/MDM2 domain	1	1
WD40 repeat-like	Ribonuclease H-like	1	1
Cryptochrome/photolyase, N-terminal domain	alpha/beta-Hydrolases	1	1
CBS-domain pair	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
Ankyrin repeat	Pseudo ankyrin repeat-like	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Ribosomal protein S2	S-adenosyl-L-methionine-dependent methyltransferases	1	1
gp5 N-terminal domain-like	alpha/beta-Hydrolases	1	1
Putative isomerase YbhE	ARM repeat	1	1
"Winged helix" DNA-binding domain	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
DNA/RNA polymerases	DNA/RNA polymerases	1	1
Cyclin-like	L domain-like	1	1
MHC antigen-recognition domain	Protein kinase-like (PK-like)	1	1
FAD/NAD(P)-binding domain	Heme-dependent catalase-like	1	1
Tudor/PWWP/MBT	P-loop containing nucleoside triphosphate hydrolases	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain II	1	1
YggU-like	Glutathione synthetase ATP-binding domain-like	1	1
L domain-like	ARM repeat	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	1	1
PUA domain-like	eIF1-like	1	1
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Ribonuclease Rh-like	Formin homology 2 domain (FH2 domain)	1	1
Tex N-terminal region-like	Nucleic acid-binding proteins	1	1
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	1	1
ClpP/crotonase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
Cullin repeat-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Protein kinase-like (PK-like)	Class II aaRS ABD-related	1	1
TPR-like	FAD/NAD(P)-binding domain	1	1
Nucleotide-diphospho-sugar transferases	ARM repeat	1	1
CBS-domain pair	DNA-binding pseudobarrel domain	1	1
NAD(P)-binding Rossmann-fold domains	Thiolase-like	1	1
NusB-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
FAD/NAD(P)-binding domain	Nucleic acid-binding proteins	1	1
Protein kinase-like (PK-like)	beta-lactamase/transpeptidase-like	1	1
Ran binding protein zinc finger-like	DNase I-like	1	1
L9 N-domain-like	Ribosomal protein L9 C-domain	1	1
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	1	1
P-loop containing nucleoside triphosphate hydrolases	Cysteine proteinases	1	1
R3H domain	Ankyrin repeat	1	1
P-loop containing nucleoside triphosphate hydrolases	Carbohydrate phosphatase	1	1
L domain-like	Actin-crosslinking proteins	1	1
Phage fibre proteins	alpha/beta-Hydrolases	1	1
Phage fibre proteins	Phage fibre proteins	1	1
Zinc beta-ribbon	Zinc beta-ribbon	1	1
FAD-binding/transporter-associated domain-like	DNA-binding pseudobarrel domain	1	1
P-loop containing nucleoside triphosphate hydrolases	PLP-dependent transferases	1	1
Protein kinase-like (PK-like)	Cytochrome P450	1	1
Terpenoid synthases	L domain-like	1	1
Quinoprotein alcohol dehydrogenase-like	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	1	1
Mitochondrial carrier	Mitochondrial carrier	1	1
Helical scaffold and wing domains of SecA	Helical scaffold and wing domains of SecA	1	1
UBA-like	NSFL1 (p97 ATPase) cofactor p47, SEP domain	1	1
TGS-like	ThrRS/AlaRS common domain	1	1
Outer arm dynein light chain 1	RNI-like	1	1
gp5 N-terminal domain-like	Ankyrin repeat	1	1
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	1	1
Eukaryotic type KH-domain (KH-domain type I)	RNA-binding domain, RBD	1	1
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	1	1
L domain-like	V-type ATP synthase subunit C	1	1
Sec63 N-terminal domain-like	DNA/RNA polymerases	1	1
Clavaminate synthase-like	Protein kinase-like (PK-like)	1	1
RNI-like	alpha/beta-Hydrolases	1	1
Cullin repeat-like	WRKY DNA-binding domain	1	1
DNA-glycosylase	DNase I-like	1	1
WGR domain-like	Phosphofructokinase	1	1
Carbohydrate phosphatase	Thiamin diphosphate-binding fold (THDP-binding)	1	1
Cytochrome P450	Homeodomain-like	1	1
TGS-like	Class II aaRS and biotin synthetases	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
Thioredoxin-like	Six-hairpin glycosidases	1	1
Nucleotidyltransferase	ACT-like	1	1
"Winged helix" DNA-binding domain	UBA-like	1	1
DNA primase core	P-loop containing nucleoside triphosphate hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	NTF2-like	1	1
HMG-box	P-loop containing nucleoside triphosphate hydrolases	1	1
Phosphoenolpyruvate/pyruvate domain	Multidrug resistance efflux transporter EmrE	1	1
Phosphoenolpyruvate/pyruvate domain	ENTH/VHS domain	1	1
TolB, C-terminal domain	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
Nucleic acid-binding proteins	TPR-like	1	1
F-box domain	LysM domain	1	1
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	1	1
PAH2 domain	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
Kelch motif	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Acetyl-CoA synthetase-like	Homeodomain-like	1	1
PH domain-like	(Phosphotyrosine protein) phosphatases II	1	1
PreATP-grasp domain	ClpP/crotonase	1	1
RNI-like	SGNH hydrolase	1	1
HAD-like	NAD(P)-binding Rossmann-fold domains	1	1
Aconitase iron-sulfur domain	Oxysterol-binding protein-like	1	1
Ankyrin repeat	Translation initiation factor IF3, C-terminal domain	1	1
GYF domain	RNA-binding domain, RBD	1	1
P-loop containing nucleoside triphosphate hydrolases	HIT-like	1	1
Nucleic acid-binding proteins	L domain-like	1	1
RNA-binding domain, RBD	N-terminal domain of alpha and beta subunits of F1 ATP synthase	1	1
Phosphoglucomutase, C-terminal domain	Phosphoglucomutase, C-terminal domain	1	1
DPP6 N-terminal domain-like	HCP-like	1	1
Subunit IX of photosystem I reaction centre, PsaJ	Zn-binding ribosomal proteins	1	1
Peptidase/esterase 'gauge' domain	SNARE fusion complex	1	1
P-loop containing nucleoside triphosphate hydrolases	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
PreATP-grasp domain	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
Periplasmic binding protein-like I	Periplasmic binding protein-like I	1	1
PH domain-like	"Winged helix" DNA-binding domain	1	1
SPOC domain-like	C-terminal domain of Ku80	1	1
Ribonuclease H-like	Protein kinase-like (PK-like)	1	1
JAB1/MPN domain	cAMP-binding domain-like	1	1
Ankyrin repeat	Translation initiation factor IF3, N-terminal domain	1	1
N-terminal domain of MutM-like DNA repair proteins	S13-like H2TH domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Retrovirus zinc finger-like domains	1	1
Glutamine synthetase/guanido kinase	GatB/YqeY motif	1	1
Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	1	1
ARM repeat	alpha/beta knot	1	1
Nucleic acid-binding proteins	SH2 domain	1	1
HMA, heavy metal-associated domain	Cu,Zn superoxide dismutase-like	1	1
Metallo-hydrolase/oxidoreductase	alpha/beta-Hydrolases	1	1
Translation proteins SH3-like domain	Translation proteins SH3-like domain	1	1
CCCH zinc finger	S-adenosyl-L-methionine-dependent methyltransferases	1	1
GST C-terminal domain-like	Ribosomal protein L25-like	1	1
Phage tail proteins	Ankyrin repeat	1	1
Protein kinase-like (PK-like)	Acyl-CoA dehydrogenase NM domain-like	1	1
RuBisCO, large subunit, small (N-terminal) domain	Ribosomal protein S8	1	1
PIN domain-like	Nucleic acid-binding proteins	1	1
Phosphoglycerate kinase	S-adenosyl-L-methionine-dependent methyltransferases	1	1
"Winged helix" DNA-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
F-box domain	DPP6 N-terminal domain-like	1	1
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	1	1
Toll/Interleukin receptor TIR domain	DNA-binding pseudobarrel domain	1	1
Calponin-homology domain, CH-domain	ARM repeat	1	1
WD40 repeat-like	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
TPR-like	Calcium-dependent phosphotriesterase	1	1
Cytochrome b559 subunits	Photosystem II reaction center protein L, PsbL	1	1
Homeodomain-like	Photosystem I subunits PsaA/PsaB	1	1
DNA repair protein MutS, domain III	SMR domain-like	1	1
GroES-like	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
Starch-binding domain-like	Starch-binding domain-like	1	1
F-box domain	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
Thiamin diphosphate-binding fold (THDP-binding)	HAD-like	1	1
HCP-like	Phospholipase D/nuclease	1	1
PUA domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
RNI-like	NTF2-like	1	1
N-terminal domain of adenylylcyclase associated protein, CAP	C-terminal domain of adenylylcyclase associated protein	1	1
Ribosomal protein L14	Translational machinery components	1	1
P-loop containing nucleoside triphosphate hydrolases	SMR domain-like	1	1
Trimeric LpxA-like enzymes	ARM repeat	1	1
Ribosomal protein L16p/L10e	Ribosomal protein L14	1	1
Carbohydrate phosphatase	HAD-like	1	1
NAD(P)-binding Rossmann-fold domains	RNI-like	1	1
Taf5 N-terminal domain-like	WD40 repeat-like	1	1
POZ domain	Pentapeptide repeat-like	1	1
Pectin lyase-like	L domain-like	1	1
Ribonuclease Rh-like	Protein kinase-like (PK-like)	1	1
Zn-binding ribosomal proteins	Ribosomal protein S18	1	1
HAD-like	RmlC-like cupins	1	1
SGNH hydrolase	SGNH hydrolase	1	1
P-loop containing nucleoside triphosphate hydrolases	Cupredoxins	1	1
SAP domain	Domain of poly(ADP-ribose) polymerase	1	1
Concanavalin A-like lectins/glucanases	Calpain large subunit, middle domain (domain III)	1	1
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	alpha/beta-Hydrolases	1	1
Sec1/munc18-like (SM) proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	1	1
Protease propeptides/inhibitors	PA domain	1	1
F-box domain	Calcium-dependent phosphotriesterase	1	1
ARM repeat	Clavaminate synthase-like	1	1
Metallo-hydrolase/oxidoreductase	Casein kinase II beta subunit	1	1
NAD(P)-binding Rossmann-fold domains	"Winged helix" DNA-binding domain	1	1
RING/U-box	Leucine zipper domain	1	1
Protein kinase-like (PK-like)	RuBisCo, C-terminal domain	1	1
DNase I-like	Clavaminate synthase-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	RING/U-box	1	1
Protein kinase-like (PK-like)	NTF2-like	1	1
SAP domain	CCCH zinc finger	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	1	1
Typo IV secretion system protein TraC	NTF2-like	1	1
beta-sandwich domain of Sec23/24	Ribosomal protein L1	1	1
Dimeric alpha+beta barrel	Dehydroquinate synthase-like	1	1
ssDNA-binding transcriptional regulator domain	ssDNA-binding transcriptional regulator domain	1	1
"Winged helix" DNA-binding domain	HRDC-like	1	1
FKBP-like	Triger factor/SurA peptide-binding domain-like	1	1
Nucleic acid-binding proteins	UBA-like	1	1
Nucleic acid-binding proteins	Ribosomal protein S7	1	1
Protein kinase-like (PK-like)	Homeodomain-like	1	1
TGS-like	ACT-like	1	1
TPR-like	F-box domain	1	1
Phage fibre proteins	Tricorn protease N-terminal domain	1	1
Ribokinase-like	Thiamin phosphate synthase	1	1
PLP-dependent transferases	Clavaminate synthase-like	1	1
Leucine zipper domain	Leucine zipper domain	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	1	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	Cupredoxins	1	1
Lipocalins	Lipocalins	1	1
Ankyrin repeat	RCC1/BLIP-II	1	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
Mog1p/PsbP-like	CRAL/TRIO domain	1	1
RNI-like	RuBisCo, C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	GIY-YIG endonuclease	1	1
Plant lectins/antimicrobial peptides	Barwin-like endoglucanases	1	1
CCCH zinc finger	WD40 repeat-like	1	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	1	1
beta-sandwich domain of Sec23/24	Acid proteases	1	1
SWIB/MDM2 domain	eIF1-like	1	1
ValRS/IleRS/LeuRS editing domain	tRNA-binding arm	1	1
HMA, heavy metal-associated domain	FAD/NAD(P)-binding domain	1	1
Hypothetical protein AF0491, middle domain	beta-beta-alpha zinc fingers	1	1
Chaperone J-domain	Multiheme cytochromes	1	1
Homeodomain-like	TATA-box binding protein-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	alpha/beta-Hydrolases	1	1
WD40 repeat-like	Cyclophilin-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Protein kinase-like (PK-like)	1	1
Protein prenylyltransferase	L domain-like	1	1
ARM repeat	"Winged helix" DNA-binding domain	1	1
C-terminal UvrC-binding domain of UvrB	ApaG-like	1	1
ACP-like	ACP-like	1	1
RNA-binding domain, RBD	DPP6 N-terminal domain-like	1	1
POZ domain	Quinoprotein alcohol dehydrogenase-like	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	PLP-dependent transferases	1	1
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	1	1
HIT/MYND zinc finger-like	SET domain	1	1
EF-hand	TPR-like	1	1
Cna protein B-type domain	Carboxypeptidase regulatory domain-like	1	1
TGS-like	Class II aaRS ABD-related	1	1
"Winged helix" DNA-binding domain	DNA-binding pseudobarrel domain	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	TATA-box binding protein-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	PLP-dependent transferases	1	1
POZ domain	Putative isomerase YbhE	1	1
F-box domain	Outer arm dynein light chain 1	1	1
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	1	1
Acyl-CoA N-acyltransferases (Nat)	RNA-binding domain, RBD	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	1	1
Retrovirus zinc finger-like domains	Actin depolymerizing proteins	1	1
FAD/NAD(P)-binding domain	NosL/MerB-like	1	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	1	1
WD40 repeat-like	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
PH domain-like	Prismane protein-like	1	1
"Winged helix" DNA-binding domain	NosL/MerB-like	1	1
Type II DNA topoisomerase	Type II DNA topoisomerase	1	1
Toll/Interleukin receptor TIR domain	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
Thioredoxin-like	VC0467-like	1	1
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	1	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	1	1
WD40 repeat-like	Toll/Interleukin receptor TIR domain	1	1
NAD(P)-binding Rossmann-fold domains	DNA/RNA polymerases	1	1
Carbohydrate phosphatase	TK C-terminal domain-like	1	1
FYVE/PHD zinc finger	RNI-like	1	1
Fucose-specific lectin	Fucose-specific lectin	1	1
beta-Galactosidase/glucuronidase domain	Galactose mutarotase-like	1	1
Sec1/munc18-like (SM) proteins	Sec1/munc18-like (SM) proteins	1	1
Ribonuclease Rh-like	Ribonuclease Rh-like	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	Phosphoglycerate kinase	1	1
Pseudo ankyrin repeat-like	TPR-like	1	1
Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin	1	1
TolB, C-terminal domain	Quinoprotein alcohol dehydrogenase-like	1	1
Starch-binding domain-like	Glutathione synthetase ATP-binding domain-like	1	1
Subtilisin-like	Cytidine deaminase-like	1	1
Skp1 dimerisation domain-like	Skp1 dimerisation domain-like	1	1
Cap-Gly domain	L domain-like	1	1
L domain-like	alpha/beta-Hydrolases	1	1
Photosystem II 10 kDa phosphoprotein PsbH	Transmembrane di-heme cytochromes	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain I	1	1
Myosin S1 fragment, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
HIT/MYND zinc finger-like	L domain-like	1	1
5' to 3' exonuclease, C-terminal subdomain	Chromo domain-like	1	1
PreATP-grasp domain	Methylglyoxal synthase-like	1	1
TPR-like	Phospholipase D/nuclease	1	1
DAK1/DegV-like	DhaL-like	1	1
HMG-box	Leucine zipper domain	1	1
HCP-like	RNI-like	1	1
HD-domain/PDEase-like	ACT-like	1	1
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
HIT/MYND zinc finger-like	Protein kinase-like (PK-like)	1	1
ARM repeat	BEACH domain	1	1
ARM repeat	Ribosomal protein L4	1	1
Cna protein B-type domain	Cna protein B-type domain	1	1
F-box domain	NTF2-like	1	1
Phosphofructokinase	"Winged helix" DNA-binding domain	1	1
Cysteine-rich domain	Caspase-like	1	1
L domain-like	FabD/lysophospholipase-like	1	1
DNA clamp	DNA clamp	1	1
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Nucleic acid-binding proteins	Protein kinase-like (PK-like)	1	1
PLP-dependent transferases	MOSC N-terminal domain-like	1	1
YgbK-like	Aldolase	1	1
PYP-like sensor domain (PAS domain)	Galactose oxidase, central domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
EPT/RTPC-like	EPT/RTPC-like	1	1
Starch-binding domain-like	Carboxypeptidase regulatory domain-like	1	1
F-box domain	Glutathione synthetase ATP-binding domain-like	1	1
DNA repair protein MutS, domain I	GIY-YIG endonuclease	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	alpha/beta-Hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	Thiamin diphosphate-binding fold (THDP-binding)	1	1
F-box domain	FtsH protease domain-like	1	1
Type II DNA topoisomerase	GyrA/ParC C-terminal domain-like	1	1
Macro domain-like	HIT-like	1	1
P-loop containing nucleoside triphosphate hydrolases	TK C-terminal domain-like	1	1
Acetyl-CoA synthetase-like	Quinoprotein alcohol dehydrogenase-like	1	1
Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	1	1
Ribonuclease H-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	1	1
SPOC domain-like	SAP domain	1	1
Concanavalin A-like lectins/glucanases	Cysteine proteinases	1	1
SSo0622-like	Kelch motif	1	1
Prokaryotic type I DNA topoisomerase	Retrovirus zinc finger-like domains	1	1
UBC-like	Class II aaRS ABD-related	1	1
Six-hairpin glycosidases	Tautomerase/MIF	1	1
MurE/MurF N-terminal domain	MurD-like peptide ligases, catalytic domain	1	1
FMN-linked oxidoreductases	alpha-helical ferredoxin	1	1
Zn-dependent exopeptidases	NAC domain	1	1
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	1	1
Cyclin-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	1	1
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	1	1
WD40 repeat-like	Galactose oxidase, central domain	1	1
Nucleic acid-binding proteins	SMAD/FHA domain	1	1
HAD-like	Nucleotide-diphospho-sugar transferases	1	1
NAD(P)-binding Rossmann-fold domains	YgbK-like	1	1
PA domain	RING/U-box	1	1
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	1	1
Rudiment single hybrid motif	ClpP/crotonase	1	1
GroES-like	DNA/RNA polymerases	1	1
Toll/Interleukin receptor TIR domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Band 7/SPFH domain	Band 7/SPFH domain	1	1
AraD/HMP-PK domain-like	HAD-like	1	1
P-loop containing nucleoside triphosphate hydrolases	UBC-like	1	1
beta-beta-alpha zinc fingers	Ankyrin repeat	1	1
Ubiquitin-like	HAD-like	1	1
Nucleotide-binding domain	Nucleotide-binding domain	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
FAD/NAD(P)-binding domain	"Winged helix" DNA-binding domain	1	1
Carbamate kinase-like	Acyl-CoA N-acyltransferases (Nat)	1	1
Acid proteases	Acid proteases	1	1
MHC antigen-recognition domain	ARM repeat	1	1
Nucleic acid-binding proteins	DNA-binding domain	1	1
PYP-like sensor domain (PAS domain)	Kelch motif	1	1
DNA-glycosylase	Nudix	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain III	1	1
WW domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
P-loop containing nucleoside triphosphate hydrolases	Cytochrome c oxidase subunit II-like, transmembrane region	1	1
SNARE-like	SNARE-like	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	MHC antigen-recognition domain	1	1
POZ domain	Galactose-binding domain-like	1	1
Starch-binding domain-like	(Trans)glycosidases	1	1
L domain-like	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	1	1
Nucleic acid-binding proteins	F-box domain	1	1
ARID-like	Homeodomain-like	1	1
SufE/NifU	NadA-like	1	1
PIN domain-like	Chromo domain-like	1	1
PUA domain-like	SWIB/MDM2 domain	1	1
Serpins	P-loop containing nucleoside triphosphate hydrolases	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	Thiolase-like	1	1
Homeodomain-like	L domain-like	1	1
TPR-like	Casein kinase II beta subunit	1	1
L domain-like	DNA-binding pseudobarrel domain	1	1
Cna protein B-type domain	Starch-binding domain-like	1	1
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	1	1
SMI1/KNR4-like	ApaG-like	1	1
Nucleic acid-binding proteins	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
NAC domain	NAC domain	1	1
F-box domain	ApaG-like	1	1
RNI-like	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
TPR-like	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	1	1
WGR domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
beta-beta-alpha zinc fingers	CCCH zinc finger	1	1
Fe-S cluster assembly (FSCA) domain-like	FKBP-like	1	1
Acyl-CoA binding protein	Ankyrin repeat	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	Ribosomal protein S5 domain 2-like	1	1
Trimeric LpxA-like enzymes	Heme-dependent catalase-like	1	1
CheY-like	DNA-binding domain	1	1
Terpenoid synthases	Terpenoid synthases	1	1
Metalloproteases ("zincins"), catalytic domain	OmpA-like	1	1
SAM/Pointed domain	Metallo-hydrolase/oxidoreductase	1	1
Oxysterol-binding protein-like	LeuD/IlvD-like	1	1
Pre-PUA domain	PUA domain-like	1	1
Multidrug resistance efflux transporter EmrE	(Trans)glycosidases	1	1
Ribonuclease H-like	SH2 domain	1	1
Band 7/SPFH domain	DNA/RNA polymerases	1	1
GST C-terminal domain-like	Nucleotidylyl transferase	1	1
Rhomboid-like	Ran binding protein zinc finger-like	1	1
Nucleotide-diphospho-sugar transferases	RmlC-like cupins	1	1
Chromo domain-like	Ankyrin repeat	1	1
Ribosomal protein S8	Ribosomal protein L36	1	1
Homeodomain-like	Toll/Interleukin receptor TIR domain	1	1
L domain-like	Glutathione synthetase ATP-binding domain-like	1	1
FAD-linked reductases, C-terminal domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
UBC-like	Protein kinase-like (PK-like)	1	1
FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	1	1
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	1	1
TK C-terminal domain-like	NAD(P)-binding Rossmann-fold domains	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Acyl-CoA dehydrogenase NM domain-like	Thioesterase/thiol ester dehydrase-isomerase	1	1
Ribosomal proteins S24e, L23 and L15e	Translation proteins SH3-like domain	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	ACT-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Prismane protein-like	1	1
Rad51 N-terminal domain-like	ARM repeat	1	1
FKBP-like	Rhodanese/Cell cycle control phosphatase	1	1
TPR-like	RNA-binding domain, RBD	1	1
R3H domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Putative cyclase	YjgF-like	1	1
Ubiquitin-like	Bromodomain	1	1
POZ domain	WD40 repeat-like	1	1
Trigger factor ribosome-binding domain	FKBP-like	1	1
RNA-binding domain, RBD	ENTH/VHS domain	1	1
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
C-terminal domain of alpha and beta subunits of F1 ATP synthase	Cupredoxins	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
alpha-helical ferredoxin	FAD/NAD(P)-binding domain	1	1
NAD(P)-binding Rossmann-fold domains	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	Dihydropteroate synthetase-like	1	1
alpha/beta-Hydrolases	FAD/NAD(P)-binding domain	1	1
dsRNA-binding domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
UBC-like	Endosomal sorting complex assembly domain	1	1
Alpha subunit of glutamate synthase, C-terminal domain	alpha-helical ferredoxin	1	1
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	1	1
HSP20-like chaperones	HSP20-like chaperones	1	1
Eukaryotic RPB5 N-terminal domain	Eukaryotic RPB5 N-terminal domain	1	1
HCP-like	Argininosuccinate synthetase, C-terminal domain	1	1
FAD/NAD(P)-binding domain	DNA-binding domain	1	1
Staphylococcal nuclease	Staphylococcal nuclease	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	1	1
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	1	1
Phosphoglycerate mutase-like	Phosphoglycerate mutase-like	1	1