Domain combination pairs in Medicago truncatula

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

1737 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
P-loop containing nucleoside triphosphate hydrolases	L domain-like	873	131
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	470	94
L domain-like	L domain-like	469	109
L domain-like	Protein kinase-like (PK-like)	446	48
Toll/Interleukin receptor TIR domain	P-loop containing nucleoside triphosphate hydrolases	423	73
F-box domain	RNI-like	383	18
Toll/Interleukin receptor TIR domain	L domain-like	361	62
RNI-like	L domain-like	333	107
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	310	65
Toll/Interleukin receptor TIR domain	"Winged helix" DNA-binding domain	253	48
"Winged helix" DNA-binding domain	L domain-like	253	51
RNA-binding domain, RBD	RNA-binding domain, RBD	208	26
alpha-D-mannose-specific plant lectins	Protein kinase-like (PK-like)	201	12
P-loop containing nucleoside triphosphate hydrolases	RNI-like	182	60
Actin-like ATPase domain	Actin-like ATPase domain	145	24
RNI-like	RNI-like	144	53
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	137	13
ABC transporter transmembrane region	ABC transporter transmembrane region	110	9
F-box domain	Galactose oxidase, central domain	105	5
Nucleic acid-binding proteins	Nucleic acid-binding proteins	102	25
RNI-like	Protein kinase-like (PK-like)	101	29
GroES-like	NAD(P)-binding Rossmann-fold domains	96	7
TPR-like	TPR-like	95	26
Thioredoxin-like	GST C-terminal domain-like	95	7
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	93	7
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	92	17
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	92	22
HAD-like	Calcium ATPase, transmembrane domain M	91	17
Calcium ATPase, transduction domain A	HAD-like	88	15
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	81	14
RING/U-box	ARM repeat	74	10
ARM repeat	ARM repeat	73	34
Thiolase-like	Thiolase-like	72	3
Cyclin-like	Cyclin-like	71	8
DNA-binding pseudobarrel domain	DNA-binding pseudobarrel domain	69	13
"Winged helix" DNA-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	66	2
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	66	9
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	66	9
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	65	5
Plant invertase/pectin methylesterase inhibitor	Pectin lyase-like	63	2
Galactose-binding domain-like	(Trans)glycosidases	63	12
RING/U-box	RING/U-box	58	20
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	57	7
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	56	6
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	56	9
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	54	6
Cupredoxins	Cupredoxins	54	5
Periplasmic binding protein-like I	Periplasmic binding protein-like II	54	5
POZ domain	Skp1 dimerisation domain-like	53	4
Terpenoid cyclases/Protein prenyltransferases	Terpenoid synthases	53	5
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	53	4
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	50	8
Concanavalin A-like lectins/glucanases	Protein kinase-like (PK-like)	50	9
Toll/Interleukin receptor TIR domain	Toll/Interleukin receptor TIR domain	49	18
(Trans)glycosidases	Glycosyl hydrolase domain	48	11
F-box domain	L domain-like	47	10
Barwin-like endoglucanases	PHL pollen allergen	47	1
Homeodomain-like	Homeodomain-like	46	14
Voltage-gated potassium channels	cAMP-binding domain-like	46	5
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	45	9
CheY-like	Homeodomain-like	45	5
Protein kinase-like (PK-like)	EF-hand	44	2
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	43	11
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	42	6
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	42	6
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	41	8
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	41	5
CCCH zinc finger	CCCH zinc finger	40	17
Ubiquitin-like	Ubiquitin-like	40	10
DNA-binding domain	DNA-binding domain	39	5
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	39	5
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipoxigenase	38	2
RNA-binding domain, RBD	Ran binding protein zinc finger-like	38	3
F-box domain	Kelch motif	38	6
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	37	6
FYVE/PHD zinc finger	FYVE/PHD zinc finger	37	18
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	36	14
Galactose-binding domain-like	Galactose-binding domain-like	36	4
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	36	12
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	36	8
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	35	7
ACT-like	ACT-like	33	12
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	32	6
Terpenoid cyclases/Protein prenyltransferases	Terpenoid cyclases/Protein prenyltransferases	30	6
ENTH/VHS domain	GAT-like domain	29	3
(Trans)glycosidases	Beta-D-glucan exohydrolase, C-terminal domain	29	2
SET domain	PUA domain-like	29	3
vWA-like	RING/U-box	28	4
DNA-binding pseudobarrel domain	CAD & PB1 domains	28	4
RING/U-box	Nucleotide-diphospho-sugar transferases	28	3
WRKY DNA-binding domain	WRKY DNA-binding domain	28	2
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	27	7
Cullin homology domain	"Winged helix" DNA-binding domain	27	4
Purple acid phosphatase, N-terminal domain	Metallo-dependent phosphatases	27	4
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	27	3
ACT-like	Protein kinase-like (PK-like)	26	2
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	26	7
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	26	15
Surp module (SWAP domain)	Surp module (SWAP domain)	26	3
FYVE/PHD zinc finger	Acyl-CoA N-acyltransferases (Nat)	25	8
Phospholipase D/nuclease	Phospholipase D/nuclease	25	9
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	25	10
GroEL equatorial domain-like	GroEL apical domain-like	24	6
PAH2 domain	PAH2 domain	24	7
P-loop containing nucleoside triphosphate hydrolases	E set domains	24	4
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	24	5
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	SAICAR synthase-like	24	6
Adenine nucleotide alpha hydrolases-like	Protein kinase-like (PK-like)	23	4
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	23	4
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	23	8
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	23	4
Homeodomain-like	Bet v1-like	23	6
Clc chloride channel	CBS-domain pair	23	4
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	23	4
PAZ domain	Ribonuclease H-like	22	4
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	22	5
EF-hand	Riboflavin synthase domain-like	22	2
Ankyrin repeat	Ankyrin repeat	22	5
DNA/RNA polymerases	Ribonuclease H-like	22	4
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	22	5
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	22	10
GroEL-intermediate domain like	GroEL apical domain-like	22	5
GroES-like	GroES-like	22	2
GroEL equatorial domain-like	GroEL-intermediate domain like	22	5
Thioredoxin-like	Thioredoxin-like	22	12
P-loop containing nucleoside triphosphate hydrolases	Nucleic acid-binding proteins	22	7
CBS-domain pair	CBS-domain pair	22	8
dsRNA-binding domain-like	dsRNA-binding domain-like	21	9
E set domains	Ankyrin repeat	21	2
FKBP-like	FKBP-like	21	8
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	21	5
Subtilisin-like	PA domain	21	4
Amine oxidase N-terminal region	Amine oxidase catalytic domain	21	3
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	21	9
P-loop containing nucleoside triphosphate hydrolases	Ankyrin repeat	21	4
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	21	6
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	21	8
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	20	1
Amine oxidase N-terminal region	Amine oxidase N-terminal region	20	3
Translation proteins	EF-G C-terminal domain-like	20	7
SNARE-like	SNARE fusion complex	20	2
Protein kinase-like (PK-like)	ARM repeat	20	17
EF-hand	P-loop containing nucleoside triphosphate hydrolases	20	5
Homodimeric domain of signal transducing histidine kinase	CheY-like	20	6
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	20	7
Double Clp-N motif	P-loop containing nucleoside triphosphate hydrolases	20	8
Homeodomain-like	"Winged helix" DNA-binding domain	20	2
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	20	3
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	20	8
EF-G C-terminal domain-like	EF-G C-terminal domain-like	20	7
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	20	1
Bet v1-like	Bet v1-like	20	6
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheY-like	20	6
WD40 repeat-like	WD40 repeat-like	19	11
Zinc hairpin stack	RING/U-box	19	5
FKBP-like	TPR-like	19	4
Cullin repeat-like	Cullin homology domain	19	4
CHY zinc finger-like	Zinc hairpin stack	18	4
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	18	3
TRAF domain-like	Ubiquitin-like	18	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	18	11
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	18	3
FYVE/PHD zinc finger	RING/U-box	18	9
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	18	7
CHY zinc finger-like	RING/U-box	18	4
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	18	13
Protein kinase-like (PK-like)	RING/U-box	18	6
Chromo domain-like	Chromo domain-like	18	3
P-loop containing nucleoside triphosphate hydrolases	RING/U-box	17	5
Acid proteases	Saposin	17	1
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	17	6
FYVE/PHD zinc finger	SET domain	17	10
F-box domain	Tubby C-terminal domain-like	17	3
EF-hand	Ferredoxin reductase-like, C-terminal NADP-linked domain	17	1
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	17	11
PK beta-barrel domain-like	PK C-terminal domain-like	17	2
C2 domain (Calcium/lipid-binding domain, CaLB)	Phospholipase D/nuclease	17	4
EGF/Laminin	Protein kinase-like (PK-like)	17	5
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	17	2
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	17	5
ARM repeat	Hect, E3 ligase catalytic domain	17	4
Starch-binding domain-like	Galactose-binding domain-like	16	3
TATA-box binding protein-like	TATA-box binding protein-like	16	2
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	16	5
FAS1 domain	FAS1 domain	16	3
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	16	4
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	16	9
TPR-like	HCP-like	16	12
YhbY-like	YhbY-like	16	6
Cullin repeat-like	"Winged helix" DNA-binding domain	16	2
UDP-Glycosyltransferase/glycogen phosphorylase	HAD-like	15	3
RING/U-box	Ankyrin repeat	15	5
Protein kinase-like (PK-like)	WD40 repeat-like	15	4
Translation proteins SH3-like domain	Nucleic acid-binding proteins	15	4
Galactose mutarotase-like	(Trans)glycosidases	15	3
EF-hand	EF-hand	15	7
P-loop containing nucleoside triphosphate hydrolases	dsRNA-binding domain-like	15	5
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	15	2
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	15	9
Translation proteins	Ribosomal protein S5 domain 2-like	15	4
Arabinanase/levansucrase/invertase	Concanavalin A-like lectins/glucanases	15	2
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	15	3
Protein kinase-like (PK-like)	TPR-like	15	3
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	15	3
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	14	2
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	14	10
HCP-like	HCP-like	14	7
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	14	3
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	14	3
Galactose mutarotase-like	Glycosyl hydrolase domain	14	2
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	14	7
Homeodomain-like	FAD-linked reductases, C-terminal domain	14	2
Homeodomain-like	FAD/NAD(P)-binding domain	14	2
PA domain	Zn-dependent exopeptidases	14	3
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	14	6
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	14	10
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	14	4
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	14	7
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	14	2
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	14	9
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	14	6
NTF2-like	RNA-binding domain, RBD	14	2
Protease propeptides/inhibitors	Subtilisin-like	13	3
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	13	5
RING/U-box	TRAF domain-like	13	3
E set domains	(Trans)glycosidases	13	6
PGBD-like	Metalloproteases ("zincins"), catalytic domain	13	2
Toll/Interleukin receptor TIR domain	RNI-like	13	9
ARM repeat	WD40 repeat-like	13	10
UBA-like	Ubiquitin-like	13	6
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	13	3
(Trans)glycosidases	Ricin B-like lectins	13	3
F-box domain	F-box domain	13	7
Calponin-homology domain, CH-domain	P-loop containing nucleoside triphosphate hydrolases	13	2
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	13	2
Tropomyosin	Tropomyosin	13	4
Carbamate kinase-like	ACT-like	13	4
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	12	4
MFS general substrate transporter	MFS general substrate transporter	12	2
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	12	2
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	12	7
Ankyrin repeat	POZ domain	12	4
PYP-like sensor domain (PAS domain)	Protein kinase-like (PK-like)	12	3
HMA, heavy metal-associated domain	HAD-like	12	9
EF-hand	PLC-like phosphodiesterases	12	3
ClpP/crotonase	ClpP/crotonase	12	5
Trypsin-like serine proteases	PDZ domain-like	12	5
Protein kinase-like (PK-like)	Ankyrin repeat	12	3
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	11	3
BAR/IMD domain-like	SH3-domain	11	1
WD40 repeat-like	Quinoprotein alcohol dehydrogenase-like	11	10
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	11	1
HAD-like	BRCT domain	11	3
GAF domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	11	4
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	11	4
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	11	1
Class II aaRS and biotin synthetases	GAD domain-like	11	3
E set domains	Glycosyl hydrolase domain	11	5
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	11	1
Flavoproteins	Riboflavin synthase domain-like	11	3
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	11	5
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	11	4
RNase III domain-like	dsRNA-binding domain-like	11	6
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	11	2
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	11	2
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	11	5
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	11	5
RING/U-box	Homeodomain-like	10	3
vWA-like	Helical domain of Sec23/24	10	4
t-snare proteins	SNARE fusion complex	10	3
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	10	4
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	10	2
ARM repeat	Sec7 domain	10	5
BRCT domain	BRCT domain	10	8
PH domain-like	Oxysterol-binding protein-like	10	1
Sec63 N-terminal domain-like	E set domains	10	4
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	10	5
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	10	4
beta-sandwich domain of Sec23/24	vWA-like	10	4
beta-sandwich domain of Sec23/24	Zn-finger domain of Sec23/24	10	4
TPR-like	Chaperone J-domain	10	4
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	10	3
RCC1/BLIP-II	RCC1/BLIP-II	10	4
TRAF domain-like	POZ domain	10	2
Galactose mutarotase-like	Galactose-binding domain-like	10	3
Zn-finger domain of Sec23/24	vWA-like	10	4
Tudor/PWWP/MBT	FYVE/PHD zinc finger	10	5
WD40 repeat-like	RING/U-box	10	6
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	10	5
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	10	4
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	10	5
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	9	3
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	9	1
Sigma3 and sigma4 domains of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	9	3
Galactose mutarotase-like	Starch-binding domain-like	9	2
Sigma2 domain of RNA polymerase sigma factors	Sigma3 and sigma4 domains of RNA polymerase sigma factors	9	3
WW domain	WW domain	9	5
Cysteine proteinases	UBA-like	9	3
RING/U-box	Cysteine proteinases	9	5
ISP domain	Bet v1-like	9	3
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	9	7
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	9	4
"Winged helix" DNA-binding domain	RNI-like	9	6
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	9	4
HD-domain/PDEase-like	Nucleotidyltransferase	9	6
PreATP-grasp domain	Rudiment single hybrid motif	9	5
ARID-like	FYVE/PHD zinc finger	9	3
P-loop containing nucleoside triphosphate hydrolases	ARM repeat	9	5
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	9	3
Tudor/PWWP/MBT	SET domain	9	4
UBA-like	UBA-like	9	7
Chromo domain-like	S-adenosyl-L-methionine-dependent methyltransferases	9	1
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	9	5
Homeodomain-like	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	9	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	9	3
Galactose oxidase, central domain	E set domains	9	2
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	9	5
(Phosphotyrosine protein) phosphatases II	Formin homology 2 domain (FH2 domain)	9	2
CCCH zinc finger	RNA-binding domain, RBD	9	4
RmlC-like cupins	RmlC-like cupins	9	2
C2 domain (Calcium/lipid-binding domain, CaLB)	Formin homology 2 domain (FH2 domain)	9	2
E set domains	CBS-domain pair	9	2
RNase III domain-like	RNase III domain-like	9	6
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	9	3
RuBisCO, large subunit, small (N-terminal) domain	RuBisCo, C-terminal domain	9	2
ARM repeat	POZ domain	9	4
Cysteine proteinases	DUSP-like	8	3
Protein kinase-like (PK-like)	Formin homology 2 domain (FH2 domain)	8	2
ADC-like	Cdc48 domain 2-like	8	4
ACT-like	NAD(P)-binding Rossmann-fold domains	8	4
Nucleotidylyl transferase	Nucleotidylyl transferase	8	1
POZ domain	POZ domain	8	6
SET domain	RuBisCo LSMT C-terminal, substrate-binding domain	8	3
Translation proteins	Initiation factor IF2/eIF5b, domain 3	8	4
Voltage-gated potassium channels	EF-hand	8	3
(Trans)glycosidases	Chitinase insertion domain	8	4
FAD/NAD(P)-binding domain	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	8	1
Nucleic acid-binding proteins	GAD domain-like	8	2
Single hybrid motif	CoA-dependent acyltransferases	8	4
HIT/MYND zinc finger-like	Cysteine proteinases	8	1
P-loop containing nucleoside triphosphate hydrolases	CYTH-like phosphatases	8	3
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	8	3
Cysteine proteinases	Granulin repeat	8	2
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	8	4
CheY-like	CheY-like	8	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	8	2
DNA-binding pseudobarrel domain	P-loop containing nucleoside triphosphate hydrolases	8	6
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	8	4
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	8	1
Adenine nucleotide alpha hydrolases-like	RING/U-box	8	1
LysM domain	Protein kinase-like (PK-like)	8	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	8	3
CAD & PB1 domains	Protein kinase-like (PK-like)	8	1
E set domains	AMPKBI-like	8	2
ThrRS/AlaRS common domain	Class II aaRS and biotin synthetases	8	4
L domain-like	Formin homology 2 domain (FH2 domain)	8	2
Zinc beta-ribbon	Cyclin-like	8	2
Actin-crosslinking proteins	(Trans)glycosidases	8	1
FAD-linked reductases, C-terminal domain	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	8	1
Actin depolymerizing proteins	Actin depolymerizing proteins	8	4
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	7	4
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	7	2
"Winged helix" DNA-binding domain	Actin-like ATPase domain	7	6
PAZ domain	RNase III domain-like	7	5
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	7	2
RNA-binding domain, RBD	PABC (PABP) domain	7	3
GAF domain-like	Homodimeric domain of signal transducing histidine kinase	7	4
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	7	2
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	7	2
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	7	2
Enolase N-terminal domain-like	Enolase C-terminal domain-like	7	3
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	7	2
RING/U-box	RNA-binding domain, RBD	7	1
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	7	3
RCC1/BLIP-II	Protein kinase-like (PK-like)	7	4
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	7	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	7	3
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	7	3
L domain-like	Actin-like ATPase domain	7	6
RCC1/BLIP-II	FYVE/PHD zinc finger	7	2
ArfGap/RecO-like zinc finger	C2 domain (Calcium/lipid-binding domain, CaLB)	7	3
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	7	3
Aconitase iron-sulfur domain	LeuD/IlvD-like	7	4
F-box domain	HCP-like	7	3
EF-hand	Mitochondrial carrier	7	2
ARID-like	HMG-box	7	4
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	7	2
POZ domain	TAZ domain	7	2
Ubiquitin-like	BAG domain	7	3
PH domain-like	Bet v1-like	7	2
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	7	4
TPR-like	Thioredoxin-like	7	4
TAZ domain	FYVE/PHD zinc finger	7	3
(Phosphotyrosine protein) phosphatases II	DNA ligase/mRNA capping enzyme, catalytic domain	7	4
Voltage-gated potassium channels	TrkA C-terminal domain-like	7	1
NAD(P)-binding Rossmann-fold domains	Galactose-binding domain-like	7	2
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	7	4
Nucleoside hydrolase	Nucleoside hydrolase	7	3
ENT-like	Tudor/PWWP/MBT	7	2
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	7	2
UBA-like	P-loop containing nucleoside triphosphate hydrolases	7	5
P-loop containing nucleoside triphosphate hydrolases	RNase III domain-like	7	5
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	7	2
TPR-like	CAD & PB1 domains	7	2
DNase I-like	EF-hand	7	4
P-loop containing nucleoside triphosphate hydrolases	Actin-like ATPase domain	7	6
Carbamate kinase-like	ALDH-like	7	1
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	7	4
Surp module (SWAP domain)	Ubiquitin-like	7	1
TAZ domain	RING/U-box	7	3
PH domain-like	P-loop containing nucleoside triphosphate hydrolases	7	3
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	7	1
Dihydrofolate reductase-like	Thymidylate synthase/dCMP hydroxymethylase	7	1
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	7	2
Class II aaRS ABD-related	C-terminal domain of ProRS	7	2
P-loop containing nucleoside triphosphate hydrolases	PAZ domain	7	5
PH domain-like	FYVE/PHD zinc finger	7	2
Periplasmic binding protein-like II	ACT-like	7	1
PDZ domain-like	ClpP/crotonase	7	1
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	7	1
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	7	2
"Winged helix" DNA-binding domain	E set domains	7	3
PurM N-terminal domain-like	PurM C-terminal domain-like	7	4
TRAF domain-like	Cysteine proteinases	7	2
FYVE/PHD zinc finger	Plus3-like	6	3
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	6	1
PH domain-like	ArfGap/RecO-like zinc finger	6	4
Trypsin-like serine proteases	Trypsin-like serine proteases	6	5
Cysteine proteinases	Sec-C motif	6	1
ACT-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	6	2
TPR-like	RING/U-box	6	3
(Phosphotyrosine protein) phosphatases II	Nucleic acid-binding proteins	6	3
Ubiquitin-like	Zn-binding ribosomal proteins	6	1
SAP domain	FYVE/PHD zinc finger	6	2
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	6	2
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	6	2
ACT-like	Formyltransferase	6	1
(Trans)glycosidases	Protein kinase-like (PK-like)	6	3
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	6	4
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	6	3
Carbamate kinase-like	NAD(P)-binding Rossmann-fold domains	6	2
MOSC N-terminal domain-like	PK beta-barrel domain-like	6	1
Actin depolymerizing proteins	VHP, Villin headpiece domain	6	2
Ribonuclease H-like	HRDC-like	6	2
Toll/Interleukin receptor TIR domain	Actin-like ATPase domain	6	5
Cap-Gly domain	Ubiquitin-like	6	2
Translational machinery components	L30e-like	6	3
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	6	3
Plant lectins/antimicrobial peptides	Lysozyme-like	6	2
SMAD/FHA domain	P-loop containing nucleoside triphosphate hydrolases	6	1
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	6	4
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	6	4
Oxidoreductase molybdopterin-binding domain	E set domains	6	3
LEA14-like	LEA14-like	6	2
Tetrahydrobiopterin biosynthesis enzymes-like	Tetrahydrobiopterin biosynthesis enzymes-like	6	2
BAR/IMD domain-like	PH domain-like	6	4
ADC-like	P-loop containing nucleoside triphosphate hydrolases	6	2
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	6	2
4Fe-4S ferredoxins	P-loop containing nucleoside triphosphate hydrolases	6	1
ARM repeat	Clathrin adaptor appendage domain	6	4
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	6	3
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	6	1
Carbamate kinase-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	6	2
RING/U-box	PUA domain-like	6	3
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	6	1
(Trans)glycosidases	(Trans)glycosidases	6	3
POZ domain	TPR-like	6	4
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	6	1
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	6	2
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	6	1
C2 domain (Calcium/lipid-binding domain, CaLB)	vWA-like	6	2
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	6	3
PriA/YqbF domain	GINS helical bundle-like	6	2
SWIB/MDM2 domain	Plus3-like	6	3
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	6	2
Retrovirus zinc finger-like domains	RING/U-box	6	1
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	6	3
Voltage-gated potassium channels	Voltage-gated potassium channels	6	3
GroEL apical domain-like	SAICAR synthase-like	6	3
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	6	2
FYVE/PHD zinc finger	Homeodomain-like	6	2
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	6	2
GST C-terminal domain-like	eEF-1beta-like	6	3
Thioredoxin-like	Cysteine-rich domain	6	2
Translation proteins	ThrRS/AlaRS common domain	6	2
PH domain-like	RCC1/BLIP-II	6	1
CBS-domain pair	CAD & PB1 domains	6	2
Ubiquitin-like	Protein kinase-like (PK-like)	6	1
FAD/NAD(P)-binding domain	EF-hand	6	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	6	4
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	6	2
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	6	2
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	6	4
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	6	1
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	5	2
P-loop containing nucleoside triphosphate hydrolases	Macro domain-like	5	3
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	5	4
ARM repeat	Tudor/PWWP/MBT	5	4
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	5	2
Thioredoxin-like	eEF1-gamma domain	5	1
UBC-like	UBA-like	5	1
SET domain	TPR-like	5	2
TPR-like	"Winged helix" DNA-binding domain	5	2
PLC-like phosphodiesterases	PLC-like phosphodiesterases	5	3
GST C-terminal domain-like	eEF1-gamma domain	5	1
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	5	4
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	5	1
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	5	4
Metallo-hydrolase/oxidoreductase	ATP-dependent DNA ligase DNA-binding domain	5	3
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	5	2
PH domain-like	Ankyrin repeat	5	3
YjgF-like	YjgF-like	5	1
SWIB/MDM2 domain	SWIB/MDM2 domain	5	2
Voltage-gated potassium channels	Ankyrin repeat	5	1
UROD/MetE-like	UROD/MetE-like	5	2
Class I glutamine amidotransferase-like	Class I glutamine amidotransferase-like	5	2
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	5	2
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	5	1
cAMP-binding domain-like	Ankyrin repeat	5	1
GAF domain-like	CheY-like	5	3
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	5	2
Protein kinase-like (PK-like)	KA1-like	5	1
Chaperone J-domain	4Fe-4S ferredoxins	5	3
CCCH zinc finger	Eukaryotic type KH-domain (KH-domain type I)	5	3
PAZ domain	dsRNA-binding domain-like	5	3
RING/U-box	UBA-like	5	2
Ribulose-phoshate binding barrel	Ribulose-phoshate binding barrel	5	2
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	5	1
F-box domain	Actin-like ATPase domain	5	1
Metallo-dependent hydrolases	Glutamine synthetase/guanido kinase	5	1
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	5	3
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	5	2
PYP-like sensor domain (PAS domain)	GAF domain-like	5	1
Metallo-hydrolase/oxidoreductase	DNA ligase/mRNA capping enzyme, catalytic domain	5	3
GAF domain-like	GAF domain-like	5	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	5	1
C-terminal domain of alpha and beta subunits of F1 ATP synthase	Epsilon subunit of F1F0-ATP synthase N-terminal domain	5	2
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	5	3
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	5	2
P-loop containing nucleoside triphosphate hydrolases	Epsilon subunit of F1F0-ATP synthase N-terminal domain	5	2
Class II aaRS and biotin synthetases	Translation proteins	5	1
TRAF domain-like	TRAF domain-like	5	4
RBP11-like subunits of RNA polymerase	Insert subdomain of RNA polymerase alpha subunit	5	3
Metallo-dependent hydrolases	Glutamine synthetase, N-terminal domain	5	1
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	5	2
ArfGap/RecO-like zinc finger	Ankyrin repeat	5	3
Protein kinase-like (PK-like)	P-loop containing nucleoside triphosphate hydrolases	5	5
CCCH zinc finger	RING/U-box	5	2
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	5	1
BEACH domain	WD40 repeat-like	5	4
alpha-D-mannose-specific plant lectins	alpha-D-mannose-specific plant lectins	5	3
Ubiquitin-like	Homeodomain-like	5	1
FYVE/PHD zinc finger	SWIB/MDM2 domain	5	2
Ricin B-like lectins	Glycosyl hydrolase domain	5	1
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	5	3
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	5	2
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	5	2
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	5	2
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	5	1
PWI domain	RNA-binding domain, RBD	5	2
Adenine nucleotide alpha hydrolases-like	YjgF-like	5	1
BAR/IMD domain-like	Ankyrin repeat	5	3
Tropomyosin	P-loop containing nucleoside triphosphate hydrolases	5	4
SMAD/FHA domain	PP2C-like	5	1
Kelch motif	Kelch motif	5	3
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	5	3
HCP-like	HIT/MYND zinc finger-like	5	2
Putative isomerase YbhE	WD40 repeat-like	4	3
Starch-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	4	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	4	1
Protein kinase-like (PK-like)	PH domain-like	4	2
PA domain	Transferrin receptor-like dimerisation domain	4	1
CCCH zinc finger	HIT-like	4	1
P-loop containing nucleoside triphosphate hydrolases	Pre-protein crosslinking domain of SecA	4	4
SNARE fusion complex	SNARE fusion complex	4	2
BRCT domain	RING/U-box	4	2
FYVE/PHD zinc finger	SAICAR synthase-like	4	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	Epsilon subunit of F1F0-ATP synthase N-terminal domain	4	1
Formate/glycerate dehydrogenase catalytic domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	4	1
FYVE/PHD zinc finger	GYF domain	4	2
PH domain-like	Phospholipase D/nuclease	4	2
Putative DNA-binding domain	Class II aaRS and biotin synthetases	4	2
PH domain-like	BEACH domain	4	3
Arp2/3 complex subunits	Arp2/3 complex subunits	4	1
FYVE/PHD zinc finger	Clavaminate synthase-like	4	2
WW domain	P-loop containing nucleoside triphosphate hydrolases	4	1
PurM N-terminal domain-like	Class I glutamine amidotransferase-like	4	2
Hypothetical protein SAV1430	Fe-S cluster assembly (FSCA) domain-like	4	1
FYVE/PHD zinc finger	GroEL apical domain-like	4	2
alpha/beta-Hydrolases	alpha/beta-Hydrolases	4	3
ARM repeat	TPR-like	4	3
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	4	3
ARM repeat	Subdomain of clathrin and coatomer appendage domain	4	3
Starch-binding domain-like	Phosphoglycerate mutase-like	4	1
E set domains	RNA-binding domain, RBD	4	1
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	4	2
Ubiquitin-like	PUG domain-like	4	3
PH domain-like	GTPase activation domain, GAP	4	1
PurM C-terminal domain-like	Class I glutamine amidotransferase-like	4	2
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	4	2
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	4	2
TPR-like	HSP20-like chaperones	4	2
ARM repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	4	4
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	4	3
WW domain	FF domain	4	3
PP2C-like	Protein kinase-like (PK-like)	4	4
Clathrin heavy-chain terminal domain	ARM repeat	4	1
vWA-like	Cysteine-rich domain	4	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	4	2
Putative DNA-binding domain	Putative DNA-binding domain	4	2
SBT domain	Ankyrin repeat	4	2
USP8 N-terminal domain-like	JAB1/MPN domain	4	2
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	4	3
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	4	2
Ubiquitin-like	Hect, E3 ligase catalytic domain	4	2
F-box domain	HIT/MYND zinc finger-like	4	1
Chitinase insertion domain	Protein kinase-like (PK-like)	4	2
Zn-dependent exopeptidases	Transferrin receptor-like dimerisation domain	4	1
Cyclophilin-like	TPR-like	4	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	4	3
MIT domain	P-loop containing nucleoside triphosphate hydrolases	4	1
PH domain-like	WD40 repeat-like	4	3
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	4	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	4	2
Globin-like	Globin-like	4	1
Hemopexin-like domain	Hemopexin-like domain	4	1
FYVE/PHD zinc finger	Ankyrin repeat	4	1
ARID-like	Clavaminate synthase-like	4	2
Chaperone J-domain	CSL zinc finger	4	2
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	4	1
tRNA-binding arm	Class II aaRS and biotin synthetases	4	2
ARM repeat	UBA-like	4	2
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	4	2
BRCT domain	FYVE/PHD zinc finger	4	3
Ubiquitin-like	Cysteine proteinases	4	2
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	4	3
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	4	2
Thioredoxin-like	"Winged helix" DNA-binding domain	4	1
WD40 repeat-like	F-box domain	4	3
PRTase-like	PRTase-like	4	2
Glutamyl tRNA-reductase catalytic, N-terminal domain	NAD(P)-binding Rossmann-fold domains	4	2
Glutamyl tRNA-reductase catalytic, N-terminal domain	Glutamyl tRNA-reductase dimerization domain	4	2
NAD(P)-binding Rossmann-fold domains	Glutamyl tRNA-reductase dimerization domain	4	2
RNA-binding domain, RBD	P-loop containing nucleoside triphosphate hydrolases	4	4
alpha-D-mannose-specific plant lectins	Hairpin loop containing domain-like	4	2
E set domains	E set domains	4	2
WD40 repeat-like	DNase I-like	4	2
Quinoprotein alcohol dehydrogenase-like	3-carboxy-cis,cis-mucoante lactonizing enzyme	4	3
PLP-binding barrel	Alanine racemase C-terminal domain-like	4	2
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	4	2
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	4	1
PRTase-like	Ribulose-phoshate binding barrel	4	1
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	4	1
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	4	3
Hairpin loop containing domain-like	Protein kinase-like (PK-like)	4	2
PH domain-like	ARM repeat	4	3
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	4	2
P-loop containing nucleoside triphosphate hydrolases	TGS-like	4	2
FF domain	FF domain	4	3
FYVE/PHD zinc finger	Transducin (alpha subunit), insertion domain	4	2
F-box domain	P-loop containing nucleoside triphosphate hydrolases	4	4
UBA-like	Hect, E3 ligase catalytic domain	4	2
Kelch motif	Metallo-dependent phosphatases	4	2
(Phosphotyrosine protein) phosphatases II	NAD kinase/diacylglycerol kinase-like	4	1
YrdC/RibB	RibA-like	4	2
ClpP/crotonase	6-phosphogluconate dehydrogenase C-terminal domain-like	4	2
PreATP-grasp domain	PreATP-grasp domain	3	3
P-loop containing nucleoside triphosphate hydrolases	RecA protein, C-terminal domain	3	2
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	3	2
Scorpion toxin-like	Scorpion toxin-like	3	2
Histone-fold	ARM repeat	3	2
Thioredoxin-like	NHL repeat	3	1
DEK C-terminal domain	ssDNA-binding transcriptional regulator domain	3	1
PLP-dependent transferases	Ornithine decarboxylase C-terminal domain	3	1
Heme oxygenase-like	HAD-like	3	2
Cytochrome f, large domain	Rudiment single hybrid motif	3	2
HLH, helix-loop-helix DNA-binding domain	ACT-like	3	2
PurS-like	PurM N-terminal domain-like	3	1
Amidase signature (AS) enzymes	TPR-like	3	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	3	2
(Phosphotyrosine protein) phosphatases II	Actin depolymerizing proteins	3	2
Quinoprotein alcohol dehydrogenase-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	3	3
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	3	1
Cystatin/monellin	Cystatin/monellin	3	3
PreATP-grasp domain	Single hybrid motif	3	3
Toll/Interleukin receptor TIR domain	UDP-Glycosyltransferase/glycogen phosphorylase	3	3
RNI-like	ARM repeat	3	1
P-loop containing nucleoside triphosphate hydrolases	Helical scaffold and wing domains of SecA	3	3
Eukaryotic type KH-domain (KH-domain type I)	LigT-like	3	2
Translation proteins	Translation proteins	3	1
PapD-like	Ankyrin repeat	3	3
Chaperone J-domain	RNA-binding domain, RBD	3	2
UBA-like	XPC-binding domain	3	2
Outer arm dynein light chain 1	L domain-like	3	3
BRCA2 helical domain	BRCA2 tower domain	3	3
L domain-like	Elongation factor Ts (EF-Ts), dimerisation domain	3	3
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	3	3
Clavaminate synthase-like	Clavaminate synthase-like	3	1
Undecaprenyl diphosphate synthase	Undecaprenyl diphosphate synthase	3	1
Chaperone J-domain	Thioredoxin-like	3	2
Ribosomal proteins S24e, L23 and L15e	Nucleic acid-binding proteins	3	2
POZ domain	RNI-like	3	2
Phage tail proteins	Phage tail proteins	3	3
HAD-like	NTF2-like	3	1
Saposin	Saposin	3	2
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Nucleic acid-binding proteins	3	2
Tropomyosin	Apolipoprotein A-I	3	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	3	1
SufE/NifU	BolA-like	3	1
Oxidoreductase molybdopterin-binding domain	Cytochrome b5-like heme/steroid binding domain	3	2
Nucleic acid-binding proteins	BRCA2 tower domain	3	3
Ubiquitin-like	XPC-binding domain	3	2
Chaperone J-domain	Sec63 N-terminal domain-like	3	1
Elongation factor Ts (EF-Ts), dimerisation domain	Elongation factor Ts (EF-Ts), dimerisation domain	3	3
Ribosomal protein L6	Ribosomal protein L6	3	1
Rudiment single hybrid motif	Single hybrid motif	3	3
Pre-protein crosslinking domain of SecA	Helical scaffold and wing domains of SecA	3	3
PRP4-like	WD40 repeat-like	3	2
MoeA N-terminal region -like	Molybdenum cofactor biosynthesis proteins	3	3
Folate-binding domain	Aminomethyltransferase beta-barrel domain	3	2
beta and beta-prime subunits of DNA dependent RNA-polymerase	beta and beta-prime subunits of DNA dependent RNA-polymerase	3	2
HAD-like	NHL repeat	3	1
GroEL-intermediate domain like	GroEL-intermediate domain like	3	2
HAD-like	Riboflavin kinase-like	3	1
Metallo-hydrolase/oxidoreductase	Nucleic acid-binding proteins	3	1
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	3	2
P-loop containing nucleoside triphosphate hydrolases	DNA/RNA polymerases	3	3
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	3	2
HIT-like	HIT-like	3	2
F-box domain	Protein kinase-like (PK-like)	3	2
Ribonuclease H-like	Ribonuclease H-like	3	2
HisI-like	all-alpha NTP pyrophosphatases	3	2
FGAM synthase PurL, linker domain	Class I glutamine amidotransferase-like	3	1
Thioredoxin-like	Ubiquitin-like	3	1
Tudor/PWWP/MBT	RNA-binding domain, RBD	3	1
PAH2 domain	F-box domain	3	1
Nucleotidylyl transferase	Ribosomal protein L25-like	3	2
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	3	2
Tricorn protease N-terminal domain	DPP6 N-terminal domain-like	3	1
Protein kinase-like (PK-like)	(Phosphotyrosine protein) phosphatases II	3	1
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	3	2
Class II aaRS and biotin synthetases	HD-domain/PDEase-like	3	3
LysM domain	LysM domain	3	1
TPR-like	PUA domain-like	3	1
Bacterial photosystem II reaction centre, L and M subunits	Photosystem II antenna protein-like	3	1
HAD-like	Glycerol-3-phosphate (1)-acyltransferase	3	1
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	3	2
Concanavalin A-like lectins/glucanases	BEACH domain	3	2
Ubiquitin-like	TPR-like	3	1
PurS-like	Class I glutamine amidotransferase-like	3	1
L domain-like	UDP-Glycosyltransferase/glycogen phosphorylase	3	3
Osmotin, thaumatin-like protein	alpha-D-mannose-specific plant lectins	3	2
P-loop containing nucleoside triphosphate hydrolases	vWA-like	3	2
DNase I-like	DNase I-like	3	2
Cullin repeat-like	Cullin repeat-like	3	3
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	3	3
Oxidoreductase molybdopterin-binding domain	Riboflavin synthase domain-like	3	2
Fe-S cluster assembly (FSCA) domain-like	Fe-S cluster assembly (FSCA) domain-like	3	1
E set domains	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
Dom34/Pelota N-terminal domain-like	L30e-like	3	1
Putative DNA-binding domain	PheT/TilS domain	3	1
AN1-like Zinc finger	AN1-like Zinc finger	3	2
Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	3	2
Cyclophilin-like	RNA-binding domain, RBD	3	1
Voltage-gated potassium channels	Glycosyl hydrolase domain	3	3
Concanavalin A-like lectins/glucanases	WD40 repeat-like	3	2
P-loop containing nucleoside triphosphate hydrolases	Elongation factor Ts (EF-Ts), dimerisation domain	3	3
Chaperone J-domain	E set domains	3	1
Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	3	1
DNA-binding domain	DNA-binding pseudobarrel domain	3	3
PH domain-like	HMG-box	3	1
Cytochrome b5-like heme/steroid binding domain	Riboflavin synthase domain-like	3	2
E set domains	Riboflavin synthase domain-like	3	2
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	3	2
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	3	1
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	3	2
PurS-like	FGAM synthase PurL, linker domain	3	1
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	3	2
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	3	2
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	3	2
PurS-like	PurM C-terminal domain-like	3	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	3	2
Flavoproteins	Protein kinase-like (PK-like)	3	1
Ribosomal L27 protein-like	Nucleic acid-binding proteins	3	2
Translational machinery components	Insert subdomain of RNA polymerase alpha subunit	3	2
Ribosomal protein S5 domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	3	2
Cytidine deaminase-like	Dihydrofolate reductase-like	3	2
BRCT domain	DNA/RNA polymerases	3	1
WD40 repeat-like	DPP6 N-terminal domain-like	3	2
PUA domain-like	Ribosomal protein S5 domain 2-like	3	2
PurM N-terminal domain-like	PurM N-terminal domain-like	3	1
BRCT domain	Lesion bypass DNA polymerase (Y-family), little finger domain	3	1
E set domains	Cytochrome b5-like heme/steroid binding domain	3	2
"Winged helix" DNA-binding domain	Elongation factor Ts (EF-Ts), dimerisation domain	3	3
Ribosomal protein S5 domain 2-like	Nucleic acid-binding proteins	3	2
Macro domain-like	CRAL/TRIO domain	3	1
WGR domain-like	Domain of poly(ADP-ribose) polymerase	3	3
PheT/TilS domain	Class II aaRS and biotin synthetases	3	1
HMA, heavy metal-associated domain	"Winged helix" DNA-binding domain	3	2
Osmotin, thaumatin-like protein	Protein kinase-like (PK-like)	3	2
Ribonuclease PH domain 2-like	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	3	2
BRCA2 helical domain	Nucleic acid-binding proteins	3	3
Heat shock protein 70kD (HSP70), C-terminal subdomain	Heat shock protein 70kD (HSP70), C-terminal subdomain	3	1
WGR domain-like	ADP-ribosylation	3	3
P-loop containing nucleoside triphosphate hydrolases	UDP-Glycosyltransferase/glycogen phosphorylase	3	3
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	3	1
Cytochrome b5-like heme/steroid binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	3	3
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	3	1
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	3	2
Cation efflux protein cytoplasmic domain-like	Cation efflux protein cytoplasmic domain-like	3	2
Translational machinery components	RBP11-like subunits of RNA polymerase	3	2
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	3	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	3	1
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	3	1
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	3	2
Actin-crosslinking proteins	Actin-crosslinking proteins	3	1
Second domain of FERM	PH domain-like	3	2
PurM C-terminal domain-like	PurM C-terminal domain-like	3	1
Concanavalin A-like lectins/glucanases	PH domain-like	3	2
FGAM synthase PurL, linker domain	PurM N-terminal domain-like	3	1
Alpha-L RNA-binding motif	Pseudouridine synthase	3	1
Oxidoreductase molybdopterin-binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
Metalloproteases ("zincins"), catalytic domain	HAD-like	3	1
WWE domain	ADP-ribosylation	3	2
HAD-like	Thioredoxin-like	3	1
Second domain of FERM	P-loop containing nucleoside triphosphate hydrolases	3	2
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	3	2
FGAM synthase PurL, linker domain	PurM C-terminal domain-like	3	1
DUSP-like	Ubiquitin-like	3	1
PUA domain-like	alpha/beta knot	3	1
PUA domain-like	P-loop containing nucleoside triphosphate hydrolases	3	2
MoeA N-terminal region -like	MoeA C-terminal domain-like	3	3
RNA-binding domain, RBD	DNase I-like	3	2
Dom34/Pelota N-terminal domain-like	Translational machinery components	3	1
L30e-like	alpha/beta knot	2	1
Six-hairpin glycosidases	AbfB domain	2	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	2	1
Hypothetical protein c14orf129, hspc210	TPR-like	2	1
Enolase N-terminal domain-like	alpha/beta-Hydrolases	2	1
Pseudouridine synthase	Pseudouridine synthase	2	1
PDZ domain-like	TPR-like	2	1
Fe-S cluster assembly (FSCA) domain-like	P-loop containing nucleoside triphosphate hydrolases	2	1
DHS-like NAD/FAD-binding domain	Enolase C-terminal domain-like	2	1
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	2	2
Heme-dependent peroxidases	Heme-dependent peroxidases	2	1
UBC-like	RING/U-box	2	2
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	1
P-loop containing nucleoside triphosphate hydrolases	D-aminoacid aminotransferase-like PLP-dependent enzymes	2	2
Ran binding protein zinc finger-like	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	2	1
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3	Eukaryotic type KH-domain (KH-domain type I)	2	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleic acid-binding proteins	2	1
HMA, heavy metal-associated domain	Toll/Interleukin receptor TIR domain	2	1
ACP-like	Trimeric LpxA-like enzymes	2	2
F-box domain	NHL repeat	2	2
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	2	1
P-loop containing nucleoside triphosphate hydrolases	TRCF domain-like	2	1
Nucleotidyltransferase	EF-hand	2	1
F-box domain	SMI1/KNR4-like	2	2
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	2	1
Urease, gamma-subunit	Metallo-dependent hydrolases	2	2
FYVE/PHD zinc finger	TPR-like	2	1
FAD/NAD(P)-binding domain	ACP-like	2	2
CAD & PB1 domains	RING/U-box	2	1
Adenine nucleotide alpha hydrolases-like	Thioredoxin-like	2	2
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	2	1
(Phosphotyrosine protein) phosphatases II	E set domains	2	2
Protein kinase-like (PK-like)	HSP20-like chaperones	2	2
Probable bacterial effector-binding domain	Probable bacterial effector-binding domain	2	2
HAD-like	dsRNA-binding domain-like	2	2
PLP-dependent transferases	PLP-dependent transferases	2	2
Surp module (SWAP domain)	ENTH/VHS domain	2	2
Riboflavin synthase domain-like	Riboflavin synthase domain-like	2	1
Cytochrome f, large domain	Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor	2	1
Plus3-like	CCCH zinc finger	2	1
UraD-Like	Transthyretin (synonym: prealbumin)	2	1
Insert subdomain of RNA polymerase alpha subunit	C-terminal domain of RNA polymerase alpha subunit	2	1
Tex N-terminal region-like	Ribonuclease H-like	2	2
Toll/Interleukin receptor TIR domain	Elongation factor Ts (EF-Ts), dimerisation domain	2	2
RING/U-box	Ran binding protein zinc finger-like	2	1
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	2	1
GST C-terminal domain-like	Ypt/Rab-GAP domain of gyp1p	2	1
RING/U-box	Cyclophilin-like	2	1
Cytidine deaminase-like	YbiA-like	2	1
Putative isomerase YbhE	Quinoprotein alcohol dehydrogenase-like	2	1
Cysteine proteinases	Protein kinase-like (PK-like)	2	2
BSD domain-like	BSD domain-like	2	1
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	2	1
Histone-fold	NAP-like	2	1
Acetyl-CoA synthetase-like	Trimeric LpxA-like enzymes	2	2
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	2	1
F-box domain	Acid proteases	2	1
L domain-like	Leucine zipper domain	2	1
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	2	1
Macro domain-like	Zn-dependent exopeptidases	2	1
PP2C-like	cAMP-binding domain-like	2	2
DHS-like NAD/FAD-binding domain	Enolase N-terminal domain-like	2	1
GYF domain	CCCH zinc finger	2	1
Barwin-like endoglucanases	Protein kinase-like (PK-like)	2	1
Toll/Interleukin receptor TIR domain	UBA-like	2	2
BRCT domain	Nucleotidyltransferase	2	1
alpha/beta-Hydrolases	P-loop containing nucleoside triphosphate hydrolases	2	2
Restriction endonuclease-like	RuvA domain 2-like	2	2
Thiamin diphosphate-binding fold (THDP-binding)	Enolase C-terminal domain-like	2	1
Thioredoxin-like	Ypt/Rab-GAP domain of gyp1p	2	1
P-loop containing nucleoside triphosphate hydrolases	RuvA domain 2-like	2	1
Pentein	Pentein	2	1
Chaperone J-domain	Homeodomain-like	2	1
HydB/Nqo4-like	4Fe-4S ferredoxins	2	2
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	2	2
NAD(P)-binding Rossmann-fold domains	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	2	1
Class I glutamine amidotransferase-like	Ribulose-phoshate binding barrel	2	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	2	2
Clavaminate synthase-like	beta-beta-alpha zinc fingers	2	2
SAND domain-like	SET domain	2	1
FAD/NAD(P)-binding domain	HI0933 insert domain-like	2	1
Aspartate/glutamate racemase	Aspartate/glutamate racemase	2	1
Cytidine deaminase-like	Cytidine deaminase-like	2	1
HMA, heavy metal-associated domain	L domain-like	2	1
Actin depolymerizing proteins	C-terminal, gelsolin-like domain of Sec23/24	2	1
Phage tail proteins	gp5 N-terminal domain-like	2	2
FAD/NAD(P)-binding domain	Acetyl-CoA synthetase-like	2	2
WD40 repeat-like	SNARE fusion complex	2	2
UBA-like	PUG domain-like	2	2
Formyltransferase	FMT C-terminal domain-like	2	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	Nucleic acid-binding proteins	2	1
ATP-dependent DNA ligase DNA-binding domain	BRCT domain	2	1
Thioredoxin-like	FAD-dependent thiol oxidase	2	1
EF-hand	Calponin-homology domain, CH-domain	2	2
BRCT domain	PsbU/PolX domain-like	2	1
Aldolase	Aminoacid dehydrogenase-like, N-terminal domain	2	1
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	2	2
PDZ domain-like	PDZ domain-like	2	1
Class I glutamine amidotransferase-like	ADC synthase	2	1
Photosystem I subunits PsaA/PsaB	Photosystem I subunits PsaA/PsaB	2	2
TPR-like	RNI-like	2	2
Cytochrome P450	Cytochrome P450	2	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	2	1
NAD(P)-binding Rossmann-fold domains	Citrate synthase	2	1
Concanavalin A-like lectins/glucanases	HSP20-like chaperones	2	2
PsbU/PolX domain-like	Nucleotidyltransferase	2	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	2	1
HIT/MYND zinc finger-like	HIT/MYND zinc finger-like	2	1
HCP-like	Homing endonucleases	2	1
Rhomboid-like	UBA-like	2	1
F-box domain	Clavaminate synthase-like	2	2
"Winged helix" DNA-binding domain	F1F0 ATP synthase subunit A	2	1
Domain of the SRP/SRP receptor G-proteins	Signal peptide-binding domain	2	1
Urease, gamma-subunit	Composite domain of metallo-dependent hydrolases	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	1
Obg GTP-binding protein N-terminal domain	Obg GTP-binding protein C-terminal domain	2	1
Nucleotidyltransferase	TGS-like	2	2
cAMP-binding domain-like	cAMP-binding domain-like	2	2
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	2	1
Thiamin diphosphate-binding fold (THDP-binding)	alpha/beta-Hydrolases	2	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
F-box domain	alpha-D-mannose-specific plant lectins	2	1
P-loop containing nucleoside triphosphate hydrolases	NAD(P)-binding Rossmann-fold domains	2	2
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	2	2
Urease, beta-subunit	Composite domain of metallo-dependent hydrolases	2	2
Nucleic acid-binding proteins	BRCT domain	2	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	2	1
Concanavalin A-like lectins/glucanases	RING/U-box	2	1
GYF domain	SET domain	2	1
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	2	1
RNA-binding domain, RBD	Retrovirus zinc finger-like domains	2	2
FAD/NAD(P)-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	2	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	2	1
Translational machinery components	C-terminal domain of RNA polymerase alpha subunit	2	1
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	2	1
vWA-like	SPOC domain-like	2	2
Ribosomal protein S5 domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
L domain-like	Cysteine proteinases	2	2
ARID-like	HSP20-like chaperones	2	1
Rad51 N-terminal domain-like	P-loop containing nucleoside triphosphate hydrolases	2	1
TRAF domain-like	Kix domain of CBP (creb binding protein)	2	1
YjeF N-terminal domain-like	FMN-binding split barrel	2	1
Mannose-binding lectins	Mannose-binding lectins	2	1
cAMP-binding domain-like	ALDH-like	2	2
Clavaminate synthase-like	RING/U-box	2	2
HMA, heavy metal-associated domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Acyl-CoA binding protein	Kelch motif	2	2
Tricorn protease domain 2	Quinoprotein alcohol dehydrogenase-like	2	2
BRCT domain	WGR domain-like	2	2
CarD-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Galactose oxidase, central domain	P-loop containing nucleoside triphosphate hydrolases	2	1
HD-domain/PDEase-like	TGS-like	2	2
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	2	1
Tubulin nucleotide-binding domain-like	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	2	1
Cullin repeat-like	POZ domain	2	1
Ankyrin repeat	TPR-like	2	2
Ribose/Galactose isomerase RpiB/AlsB	RmlC-like cupins	2	1
Diaminopimelate epimerase-like	Diaminopimelate epimerase-like	2	1
Rudiment single hybrid motif	Cytochrome f subunit of the cytochrome b6f complex, transmembrane anchor	2	1
PUA domain-like	Nucleotidylyl transferase	2	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	2	2
Urease, gamma-subunit	Urease, beta-subunit	2	2
Transmembrane di-heme cytochromes	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	2	1
Ribonuclease H-like	Nucleic acid-binding proteins	2	2
Acetyl-CoA synthetase-like	ACP-like	2	2
Aldolase	NAD(P)-binding Rossmann-fold domains	2	1
Outer arm dynein light chain 1	Protein kinase-like (PK-like)	2	2
Serine metabolism enzymes domain	ACT-like	2	2
BRCT domain	ADP-ribosylation	2	2
P-loop containing nucleoside triphosphate hydrolases	Glucocorticoid receptor-like (DNA-binding domain)	2	2
WD40 repeat-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	2	2
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	2	1
Plus3-like	GYF domain	2	1
Actin-like ATPase domain	AF1104-like	2	1
FYVE/PHD zinc finger	SAND domain-like	2	1
Mechanosensitive channel protein MscS (YggB), transmembrane region	Sm-like ribonucleoproteins	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	2	1
Smc hinge domain	Tropomyosin	2	1
Glycerol-3-phosphate (1)-acyltransferase	EF-hand	2	1
SMAD/FHA domain	Phospholipase D/nuclease	2	2
RNA-binding domain, RBD	WW domain	2	1
gp5 N-terminal domain-like	Phage fibre proteins	2	2
NTF2-like	Probable bacterial effector-binding domain	2	1
PGBD-like	DnaJ/Hsp40 cysteine-rich domain	2	1
Nucleic acid-binding proteins	S15/NS1 RNA-binding domain	2	1
BRCT domain	Domain of poly(ADP-ribose) polymerase	2	2
Cullin repeat-like	Skp1 dimerisation domain-like	2	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	2	1
Glucocorticoid receptor-like (DNA-binding domain)	HAD-like	2	2
WD40 repeat-like	Bromodomain	2	1
GroEL equatorial domain-like	DNA-binding domain	2	1
L domain-like	Ubiquitin-like	2	2
RNA-binding domain, RBD	Clavaminate synthase-like	2	1
Single hybrid motif	Single hybrid motif	2	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	2	1
ARM repeat	alpha/beta-Hydrolases	2	1
HIT/MYND zinc finger-like	RING/U-box	2	1
Urease, beta-subunit	Metallo-dependent hydrolases	2	2
PX domain	BAR/IMD domain-like	2	2
Ribonuclease H-like	RuvA domain 2-like	2	2
PH domain-like	BSD domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	HRDC-like	2	2
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	2	2
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	2	2
L domain-like	UBA-like	2	2
RuvA domain 2-like	Nucleic acid-binding proteins	2	2
PDZ domain-like	(Phosphotyrosine protein) phosphatases II	2	2
FYVE/PHD zinc finger	PUA domain-like	2	1
TAZ domain	TAZ domain	2	1
Formate/glycerate dehydrogenase catalytic domain-like	Formate/glycerate dehydrogenase catalytic domain-like	2	1
cAMP-binding domain-like	Thioesterase/thiol ester dehydrase-isomerase	2	1
Nitrite and sulphite reductase 4Fe-4S domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	2	2
Lipoxigenase	Class II aaRS and biotin synthetases	2	1
CarD-like	TRCF domain-like	2	1
FYVE/PHD zinc finger	CCCH zinc finger	2	1
Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	2	2
Ribosomal protein S2	Nucleotide-diphospho-sugar transferases	2	1
beta-sandwich domain of Sec23/24	Leucine zipper domain	2	1
Voltage-gated potassium channels	NAD(P)-binding Rossmann-fold domains	2	1
SAP domain	DNase I-like	2	1
Ran binding protein zinc finger-like	P-loop containing nucleoside triphosphate hydrolases	2	1
P-loop containing nucleoside triphosphate hydrolases	FAD/NAD(P)-binding domain	2	1
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
RuvA domain 2-like	RuvA domain 2-like	2	2
Tudor/PWWP/MBT	SAND domain-like	2	1
Translation proteins SH3-like domain	Ribosomal protein S19	2	1
Cysteine-rich domain	Cysteine-rich domain	2	2
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	2	2
Dihydrofolate reductase-like	YbiA-like	2	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	2	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	2	1
SWIB/MDM2 domain	GYF domain	2	1
ARM repeat	SH3-domain	2	2
BRCT domain	post-AAA+ oligomerization domain-like	2	1
Thiamin diphosphate-binding fold (THDP-binding)	Enolase N-terminal domain-like	2	1
DHS-like NAD/FAD-binding domain	alpha/beta-Hydrolases	2	1
Methylglyoxal synthase-like	Cytidine deaminase-like	2	1
Thioredoxin-like	ERP29 C domain-like	2	1
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	2	2
Phage tail proteins	Phage fibre proteins	2	2
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	2	2
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	2	1
ADP-ribosylation	Hemopexin-like domain	2	2
Chelatase	Chlorophyll a-b binding protein	2	1
C-terminal, gelsolin-like domain of Sec23/24	VHP, Villin headpiece domain	2	1
SWIB/MDM2 domain	CCCH zinc finger	2	1
PYP-like sensor domain (PAS domain)	F-box domain	2	2
HMG-box	HMG-box	2	2
Ran binding protein zinc finger-like	Translation proteins	2	1
Nqo1 middle domain-like	Nqo1C-terminal domain-like	2	1
CAD & PB1 domains	UBA-like	2	1
BRCT domain	DNA polymerase beta, N-terminal domain-like	2	1
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	2	1
SAP domain	RNA-binding domain, RBD	2	1
UDP-Glycosyltransferase/glycogen phosphorylase	NAD(P)-binding Rossmann-fold domains	2	2
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	2	1
FAD/NAD(P)-binding domain	SMAD/FHA domain	2	1
FAD/NAD(P)-binding domain	Trimeric LpxA-like enzymes	2	2
Activator of Hsp90 ATPase, Aha1	Bet v1-like	2	1
RBP11-like subunits of RNA polymerase	C-terminal domain of RNA polymerase alpha subunit	2	1
HD-domain/PDEase-like	EF-hand	2	1
Tricorn protease domain 2	WD40 repeat-like	2	2
F-box domain	Leucine zipper domain	2	1
cAMP-binding domain-like	Protein kinase-like (PK-like)	2	2
P-loop containing nucleoside triphosphate hydrolases	Obg GTP-binding protein C-terminal domain	2	1
Dcp2 domain-like	Nudix	2	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	2	1
Periplasmic binding protein-like II	GlnB-like	2	1
Ribosomal proteins S24e, L23 and L15e	YWTD domain	2	1
Calcyclin-binding protein-like	HSP20-like chaperones	2	1
Ribonuclease H-like	Eukaryotic type KH-domain (KH-domain type I)	2	1
Enolase C-terminal domain-like	alpha/beta-Hydrolases	2	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	2	1
TPR-like	Metallo-dependent phosphatases	2	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	2	2
GST C-terminal domain-like	Nucleotidylyl transferase	1	1
Band 7/SPFH domain	DNA/RNA polymerases	1	1
FYVE/PHD zinc finger	Chromo domain-like	1	1
Starch-binding domain-like	(Trans)glycosidases	1	1
HIT/MYND zinc finger-like	Protein kinase-like (PK-like)	1	1
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	1	1
L9 N-domain-like	Ribosomal protein L9 C-domain	1	1
Translation proteins SH3-like domain	Translation proteins SH3-like domain	1	1
Protein kinase-like (PK-like)	beta-lactamase/transpeptidase-like	1	1
Sec63 N-terminal domain-like	DNA/RNA polymerases	1	1
HAD-like	Nucleotide-diphospho-sugar transferases	1	1
Pectin lyase-like	RmlC-like cupins	1	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	1	1
F-box domain	ApaG-like	1	1
D-aminoacid aminotransferase-like PLP-dependent enzymes	D-aminoacid aminotransferase-like PLP-dependent enzymes	1	1
FMN-dependent nitroreductase-like	FMN-dependent nitroreductase-like	1	1
Ribulose-phoshate binding barrel	HAD-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Typo IV secretion system protein TraC	1	1
NAD(P)-binding Rossmann-fold domains	RNI-like	1	1
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	1	1
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	1	1
TolB, C-terminal domain	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
MetI-like	P-loop containing nucleoside triphosphate hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	SMR domain-like	1	1
Ribosomal protein S2	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Protein prenylyltransferase	L domain-like	1	1
HSP20-like chaperones	HSP20-like chaperones	1	1
WGR domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	ACT-like	1	1
Thiamin diphosphate-binding fold (THDP-binding)	NAD(P)-binding Rossmann-fold domains	1	1
P-loop containing nucleoside triphosphate hydrolases	Carbohydrate phosphatase	1	1
Terpenoid synthases	Terpenoid synthases	1	1
PH domain-like	"Winged helix" DNA-binding domain	1	1
PDZ domain-like	Rubredoxin-like	1	1
Kelch motif	S-adenosyl-L-methionine-dependent methyltransferases	1	1
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	1	1
FYSH domain	beta-beta-alpha zinc fingers	1	1
Ribosomal protein S8	Ribosomal protein L36	1	1
Phosphoenolpyruvate/pyruvate domain	ENTH/VHS domain	1	1
"Winged helix" DNA-binding domain	UBA-like	1	1
Nucleotide-diphospho-sugar transferases	RmlC-like cupins	1	1
P-loop containing nucleoside triphosphate hydrolases	Pili subunits	1	1
Cullin repeat-like	WRKY DNA-binding domain	1	1
Ribonuclease Rh-like	Ribonuclease Rh-like	1	1
ACP-like	Heme-dependent catalase-like	1	1
Periplasmic binding protein-like II	MetI-like	1	1
TAF(II)230 TBP-binding fragment	Bromodomain	1	1
Carbohydrate phosphatase	HAD-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Thiamin diphosphate-binding fold (THDP-binding)	1	1
Phosphofructokinase	NAD(P)-binding Rossmann-fold domains	1	1
Cytochrome b559 subunits	Photosystem II reaction center protein L, PsbL	1	1
L domain-like	Glutathione synthetase ATP-binding domain-like	1	1
Quinoprotein alcohol dehydrogenase-like	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain I	1	1
TPR-like	Calcium-dependent phosphotriesterase	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	MHC antigen-recognition domain	1	1
FAD/NAD(P)-binding domain	Thioredoxin-like	1	1
Typo IV secretion system protein TraC	NTF2-like	1	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	1	1
POZ domain	Galactose-binding domain-like	1	1
NAD(P)-binding Rossmann-fold domains	"Winged helix" DNA-binding domain	1	1
GroES-like	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
TPR-like	Phospholipase D/nuclease	1	1
CCCH zinc finger	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
Ankyrin repeat	DNA/RNA polymerases	1	1
Cysteine-rich domain	Caspase-like	1	1
ValRS/IleRS/LeuRS editing domain	tRNA-binding arm	1	1
GST C-terminal domain-like	Ribosomal protein L25-like	1	1
POZ domain	Pentapeptide repeat-like	1	1
Protein kinase-like (PK-like)	BEACH domain	1	1
Ribonuclease H-like	P-loop containing nucleoside triphosphate hydrolases	1	1
RuvA domain 2-like	SH2 domain	1	1
SGNH hydrolase	SGNH hydrolase	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	"Winged helix" DNA-binding domain	1	1
TPR-like	F-box domain	1	1
alpha/beta-Hydrolases	FAD/NAD(P)-binding domain	1	1
WGR domain-like	Phosphofructokinase	1	1
Glutamine synthetase/guanido kinase	GatB/YqeY motif	1	1
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	1	1
Nucleic acid-binding proteins	F-box domain	1	1
Starch-binding domain-like	Carboxypeptidase regulatory domain-like	1	1
Homeodomain-like	Photosystem I subunits PsaA/PsaB	1	1
vWA-like	SAP domain	1	1
UBC-like	UBC-like	1	1
Chaperone J-domain	Multiheme cytochromes	1	1
WD40 repeat-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	1	1
PLP-dependent transferases	MOSC N-terminal domain-like	1	1
TAF(II)230 TBP-binding fragment	Ubiquitin-like	1	1
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	1	1
Helical scaffold and wing domains of SecA	Helical scaffold and wing domains of SecA	1	1
Rudiment single hybrid motif	ClpP/crotonase	1	1
Trigger factor ribosome-binding domain	FKBP-like	1	1
Plant lectins/antimicrobial peptides	Barwin-like endoglucanases	1	1
Carbohydrate phosphatase	Thiamin diphosphate-binding fold (THDP-binding)	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
N-terminal domain of MutM-like DNA repair proteins	S13-like H2TH domain	1	1
RNI-like	RuBisCo, C-terminal domain	1	1
Ankyrin repeat	Translation initiation factor IF3, C-terminal domain	1	1
Type II DNA topoisomerase	Type II DNA topoisomerase	1	1
F-box domain	FtsH protease domain-like	1	1
alpha/beta knot	Nucleic acid-binding proteins	1	1
Concanavalin A-like lectins/glucanases	Calpain large subunit, middle domain (domain III)	1	1
FYVE/PHD zinc finger	Bromodomain	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
P-loop containing nucleoside triphosphate hydrolases	GIY-YIG endonuclease	1	1
Fucose-specific lectin	Fucose-specific lectin	1	1
GAF domain-like	Acetyl-CoA synthetase-like	1	1
Concanavalin A-like lectins/glucanases	SH2 domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	1	1
Subunit IX of photosystem I reaction centre, PsaJ	Zn-binding ribosomal proteins	1	1
P-loop containing nucleoside triphosphate hydrolases	HIT-like	1	1
Terpenoid synthases	L domain-like	1	1
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	1	1
P-loop containing nucleoside triphosphate hydrolases	NTF2-like	1	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	1	1
Starch-binding domain-like	Starch-binding domain-like	1	1
Phage fibre proteins	alpha/beta-Hydrolases	1	1
Trimeric LpxA-like enzymes	ARM repeat	1	1
SMI1/KNR4-like	ApaG-like	1	1
Cytochrome P450	Homeodomain-like	1	1
Ribonuclease H-like	SH2 domain	1	1
Protein kinase-like (PK-like)	Class II aaRS ABD-related	1	1
HAD-like	RmlC-like cupins	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	1	1
lambda repressor-like DNA-binding domains	RmlC-like cupins	1	1
PLP-dependent transferases	Clavaminate synthase-like	1	1
Ribonuclease Rh-like	Protein kinase-like (PK-like)	1	1
Protein kinase-like (PK-like)	RuBisCo, C-terminal domain	1	1
Pseudo ankyrin repeat-like	TPR-like	1	1
Ribosomal protein L16p/L10e	Ribosomal protein L14	1	1
WD40 repeat-like	Cyclophilin-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	alpha/beta-Hydrolases	1	1
PUA domain-like	SWIB/MDM2 domain	1	1
Ribonuclease Rh-like	Formin homology 2 domain (FH2 domain)	1	1
TPR-like	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	1	1
S15/NS1 RNA-binding domain	HydB/Nqo4-like	1	1
"Winged helix" DNA-binding domain	HRDC-like	1	1
UBC-like	Endosomal sorting complex assembly domain	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	Ribosomal protein S5 domain 2-like	1	1
Terpenoid synthases	Protein kinase-like (PK-like)	1	1
Cna protein B-type domain	Starch-binding domain-like	1	1
Metallo-hydrolase/oxidoreductase	TPR-like	1	1
Phosphoglucomutase, C-terminal domain	Phosphoglucomutase, C-terminal domain	1	1
FAD-binding/transporter-associated domain-like	DNA-binding pseudobarrel domain	1	1
Ubiquitin-like	Bromodomain	1	1
Ribonuclease H-like	Protein kinase-like (PK-like)	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	PLP-dependent transferases	1	1
Protein kinase-like (PK-like)	HCP-like	1	1
FAD/NAD(P)-binding domain	NosL/MerB-like	1	1
gp5 N-terminal domain-like	Ankyrin repeat	1	1
Phosphoglycerate kinase	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	1	1
ARM repeat	Chaperone J-domain	1	1
Thioredoxin-like	Ribonuclease Rh-like	1	1
ARM repeat	Acid proteases	1	1
Poly A polymerase C-terminal region-like	Poly A polymerase C-terminal region-like	1	1
FAD/NAD(P)-binding domain	DNA-binding domain	1	1
Multidrug resistance efflux transporter EmrE	(Trans)glycosidases	1	1
PAH2 domain	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	alpha/beta-Hydrolases	1	1
F-box domain	YWTD domain	1	1
CCCH zinc finger	WD40 repeat-like	1	1
Aquaporin-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Ribonuclease H-like	Alkaline phosphatase-like	1	1
Phosphoenolpyruvate/pyruvate domain	Multidrug resistance efflux transporter EmrE	1	1
SufE/NifU	NadA-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	Retrovirus zinc finger-like domains	1	1
RNA-binding domain, RBD	Surp module (SWAP domain)	1	1
Macro domain-like	HIT-like	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
L domain-like	RING/U-box	1	1
"Winged helix" DNA-binding domain	GAF domain-like	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain II	1	1
FMN-linked oxidoreductases	FAD/NAD(P)-binding domain	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	Dihydropteroate synthetase-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	RING/U-box	1	1
Oxysterol-binding protein-like	LeuD/IlvD-like	1	1
Acyl-CoA N-acyltransferases (Nat)	BRCT domain	1	1
vWA-like	C-terminal domain of Ku80	1	1
Nucleic acid-binding proteins	SH2 domain	1	1
DNase I-like	Clavaminate synthase-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	RNA-binding domain, RBD	1	1
Metalloproteases ("zincins"), catalytic domain	OmpA-like	1	1
Thioredoxin-like	VC0467-like	1	1
(Phosphotyrosine protein) phosphatases II	RNA-binding domain, RBD	1	1
Acid proteases	Acid proteases	1	1
PDZ domain-like	E set domains	1	1
ClpP/crotonase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
Aquaporin-like	HMA, heavy metal-associated domain	1	1
Phage tail proteins	Ankyrin repeat	1	1
Homeodomain-like	L domain-like	1	1
Acyl-CoA dehydrogenase NM domain-like	Thioesterase/thiol ester dehydrase-isomerase	1	1
S-adenosyl-L-methionine-dependent methyltransferases	alpha-D-mannose-specific plant lectins	1	1
UBC-like	Class II aaRS ABD-related	1	1
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	1	1
Protein kinase-like (PK-like)	PR-1-like	1	1
Protein kinase-like (PK-like)	Cytochrome P450	1	1
beta-Galactosidase/glucuronidase domain	Galactose mutarotase-like	1	1
CoA-dependent acyltransferases	CoA-dependent acyltransferases	1	1
F-box domain	LysM domain	1	1
Leucine zipper domain	Chaperone J-domain	1	1
F-box domain	Pectin lyase-like	1	1
Acyl-CoA binding protein	Ankyrin repeat	1	1
Phage tail proteins	Tricorn protease N-terminal domain	1	1
MurE/MurF N-terminal domain	MurD-like peptide ligases, peptide-binding domain	1	1
Outer arm dynein light chain 1	RNI-like	1	1
Ran binding protein zinc finger-like	DNase I-like	1	1
P-loop containing nucleoside triphosphate hydrolases	HAD-like	1	1
Nucleic acid-binding proteins	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Cytochrome b5-like heme/steroid binding domain	alpha/beta-Hydrolases	1	1
Pre-PUA domain	PUA domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Prismane protein-like	1	1
ClpP/crotonase	Thiolase-like	1	1
PH domain-like	Prismane protein-like	1	1
POZ domain	Putative isomerase YbhE	1	1
DNA-glycosylase	Nudix	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Toll/Interleukin receptor TIR domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
P-loop containing nucleoside triphosphate hydrolases	Cysteine proteinases	1	1
FKBP-like	Rhodanese/Cell cycle control phosphatase	1	1
gp5 N-terminal domain-like	gp5 N-terminal domain-like	1	1
Starch-binding domain-like	Nucleic acid-binding proteins	1	1
SSo0622-like	Kelch motif	1	1
F-box domain	DPP6 N-terminal domain-like	1	1
Phosphofructokinase	"Winged helix" DNA-binding domain	1	1
Glutathione synthetase ATP-binding domain-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	1	1
FAD-linked reductases, C-terminal domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	1	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	1	1
AN1-like Zinc finger	beta-beta-alpha zinc fingers	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	1	1
Fe-S cluster assembly (FSCA) domain-like	FKBP-like	1	1
ISP transmembrane anchor	ISP domain	1	1
SNARE-like	SNARE-like	1	1
N-terminal domain of adenylylcyclase associated protein, CAP	C-terminal domain of adenylylcyclase associated protein	1	1
TolB, C-terminal domain	Quinoprotein alcohol dehydrogenase-like	1	1
Calponin-homology domain, CH-domain	ARM repeat	1	1
Trimeric LpxA-like enzymes	Heme-dependent catalase-like	1	1
Alpha subunit of glutamate synthase, C-terminal domain	FAD/NAD(P)-binding domain	1	1
DNA clamp	DNA clamp	1	1
NAD(P)-binding Rossmann-fold domains	YgbK-like	1	1
Ribosomal proteins S24e, L23 and L15e	Translation proteins SH3-like domain	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	1	1
Nucleic acid-binding proteins	RNA-binding domain, RBD	1	1
PreATP-grasp domain	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
DNA-glycosylase	DNase I-like	1	1
EPT/RTPC-like	EPT/RTPC-like	1	1
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	1	1
Single hybrid motif	ClpP/crotonase	1	1
PUA domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
beta-sandwich domain of Sec23/24	Ribosomal protein L1	1	1
Zinc beta-ribbon	Zinc beta-ribbon	1	1
Class II aaRS and biotin synthetases	Class II aaRS and biotin synthetases	1	1
P-loop containing nucleoside triphosphate hydrolases	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
ARM repeat	Clavaminate synthase-like	1	1
Oxygen-evolving enhancer protein 3,	Cyclophilin-like	1	1
Nucleotide-diphospho-sugar transferases	ARM repeat	1	1
CheY-like	DNA-binding domain	1	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	Cytochrome c oxidase subunit II-like, transmembrane region	1	1
Concanavalin A-like lectins/glucanases	Cysteine proteinases	1	1
FAD/NAD(P)-binding domain	Heme-dependent catalase-like	1	1
HD-domain/PDEase-like	ACT-like	1	1
DNA-binding pseudobarrel domain	Ribonuclease H-like	1	1
SAP domain	ADP-ribosylation	1	1
FYVE/PHD zinc finger	Actin-like ATPase domain	1	1
ARM repeat	"Winged helix" DNA-binding domain	1	1
Pectin lyase-like	Pectin lyase-like	1	1
Aldolase	Ribulose-phoshate binding barrel	1	1
Toll/Interleukin receptor TIR domain	DNA-binding pseudobarrel domain	1	1
RNA-binding domain, RBD	DPP6 N-terminal domain-like	1	1
Photosystem II 10 kDa phosphoprotein PsbH	Transmembrane di-heme cytochromes	1	1
Rhomboid-like	Ran binding protein zinc finger-like	1	1
Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin	1	1
TPR-like	FAD/NAD(P)-binding domain	1	1
Homeodomain-like	Toll/Interleukin receptor TIR domain	1	1
PreATP-grasp domain	Methylglyoxal synthase-like	1	1
DNA-binding pseudobarrel domain	Nucleic acid-binding proteins	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	TATA-box binding protein-like	1	1
Ribosomal protein L14	Translational machinery components	1	1
L domain-like	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
Zn-binding ribosomal proteins	Ribosomal protein S18	1	1
Phage fibre proteins	Phage fibre proteins	1	1
HMA, heavy metal-associated domain	Cu,Zn superoxide dismutase-like	1	1
Homeodomain-like	Tetracyclin repressor-like, C-terminal domain	1	1
PYP-like sensor domain (PAS domain)	Galactose oxidase, central domain	1	1
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	1	1
Terpenoid synthases	Outer arm dynein light chain 1	1	1
gp5 N-terminal domain-like	Tricorn protease N-terminal domain	1	1
SPOC domain-like	SAP domain	1	1
Nucleic acid-binding proteins	DNA-binding domain	1	1
Zn-dependent exopeptidases	Protein kinase-like (PK-like)	1	1
Staphylococcal nuclease	Staphylococcal nuclease	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	1	1
TGS-like	ThrRS/AlaRS common domain	1	1
Protein kinase-like (PK-like)	Metal cation-transporting ATPase, ATP-binding domain N	1	1
ARM repeat	Concanavalin A-like lectins/glucanases	1	1
TPR-like	Casein kinase II beta subunit	1	1
Multidrug resistance efflux transporter EmrE	ENTH/VHS domain	1	1
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	1	1
PIN domain-like	Chromo domain-like	1	1
L domain-like	Actin-crosslinking proteins	1	1
Hypothetical protein AF0491, middle domain	beta-beta-alpha zinc fingers	1	1
Nucleic acid-binding proteins	SMAD/FHA domain	1	1
C-type lectin-like	Protein kinase-like (PK-like)	1	1
Nucleic acid-binding proteins	UBA-like	1	1
PUA domain-like	eIF1-like	1	1
SPOC domain-like	C-terminal domain of Ku80	1	1
C-terminal domain of alpha and beta subunits of F1 ATP synthase	Cupredoxins	1	1
FKBP-like	Triger factor/SurA peptide-binding domain-like	1	1
"Winged helix" DNA-binding domain	NosL/MerB-like	1	1
TGS-like	Class II aaRS ABD-related	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	alpha/beta-Hydrolases	1	1
Ankyrin repeat	Pseudo ankyrin repeat-like	1	1
Translation proteins	Nucleotide-diphospho-sugar transferases	1	1
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	1	1
WW domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	1	1
Aconitase iron-sulfur domain	Oxysterol-binding protein-like	1	1
Clavaminate synthase-like	Protein kinase-like (PK-like)	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
DNA repair protein MutS, domain I	GIY-YIG endonuclease	1	1
P-loop containing nucleoside triphosphate hydrolases	TK C-terminal domain-like	1	1
Translation proteins	PRC-barrel domain	1	1
Metallo-hydrolase/oxidoreductase	Protein kinase-like (PK-like)	1	1
PYP-like sensor domain (PAS domain)	Kelch motif	1	1
Glutathione synthetase ATP-binding domain-like	Phosphohistidine domain	1	1
"Winged helix" DNA-binding domain	Acetyl-CoA synthetase-like	1	1
NAD(P)-binding Rossmann-fold domains	F-box domain	1	1
Nucleic acid-binding proteins	TPR-like	1	1
Tricorn protease N-terminal domain	Tricorn protease N-terminal domain	1	1
AraD/HMP-PK domain-like	HAD-like	1	1
MFS general substrate transporter	Alkaline phosphatase-like	1	1
L domain-like	FabD/lysophospholipase-like	1	1
Acetyl-CoA synthetase-like	Quinoprotein alcohol dehydrogenase-like	1	1
YggU-like	Glutathione synthetase ATP-binding domain-like	1	1
Nucleic acid-binding proteins	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
Pectin lyase-like	L domain-like	1	1
DAK1/DegV-like	DhaL-like	1	1
Thioredoxin-like	Six-hairpin glycosidases	1	1
Ankyrin repeat	Translation initiation factor IF3, N-terminal domain	1	1
Dimeric alpha+beta barrel	Dehydroquinate synthase-like	1	1
Retrovirus zinc finger-like domains	Actin depolymerizing proteins	1	1
DNA/RNA polymerases	DNA/RNA polymerases	1	1
HAD-like	NAD(P)-binding Rossmann-fold domains	1	1
NAD(P)-binding Rossmann-fold domains	Thiolase-like	1	1
Nucleic acid-binding proteins	L domain-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	Thiolase-like	1	1
UBC-like	Protein kinase-like (PK-like)	1	1
WD40 repeat-like	NHL repeat	1	1
XRCC4, N-terminal domain	XRCC4, C-terminal oligomerization domain	1	1
L domain-like	alpha/beta-Hydrolases	1	1
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	1	1
Ribonuclease H-like	DNase I-like	1	1
Protein kinase-like (PK-like)	Homeodomain-like	1	1
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	1	1
WD40 repeat-like	Ribonuclease H-like	1	1
CBS-domain pair	DNA-binding pseudobarrel domain	1	1
ARM repeat	F-box domain	1	1
alpha/beta-Hydrolases	HCP-like	1	1
Aldolase	HAD-like	1	1
Nucleotidylyl transferase	tRNA-binding arm	1	1
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	1	1
FYVE/PHD zinc finger	RNI-like	1	1
Carbohydrate phosphatase	NAD(P)-binding Rossmann-fold domains	1	1
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	1	1
Cysteine proteinases	DNA-binding pseudobarrel domain	1	1
WD40 repeat-like	Nucleoporin domain	1	1
Protease propeptides/inhibitors	PA domain	1	1
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	Phosphoglycerate kinase	1	1
R3H domain	Ankyrin repeat	1	1
F-box domain	SET domain	1	1
MHC antigen-recognition domain	Protein kinase-like (PK-like)	1	1
YgbK-like	Aldolase	1	1
Phosphoglycerate mutase-like	Phosphoglycerate mutase-like	1	1
Nucleic acid-binding proteins	Ribosomal protein S7	1	1
SAP domain	WGR domain-like	1	1
beta-beta-alpha zinc fingers	CCCH zinc finger	1	1
RNI-like	NTF2-like	1	1
PLP-dependent transferases	(Trans)glycosidases	1	1
Skp1 dimerisation domain-like	Skp1 dimerisation domain-like	1	1
HMG-box	P-loop containing nucleoside triphosphate hydrolases	1	1
Peptidase/esterase 'gauge' domain	SNARE fusion complex	1	1
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Phage fibre proteins	Tricorn protease N-terminal domain	1	1
PRC-barrel domain	Nucleotide-diphospho-sugar transferases	1	1
PA domain	RING/U-box	1	1
Mitochondrial carrier	Mitochondrial carrier	1	1
alpha-helical ferredoxin	FAD/NAD(P)-binding domain	1	1
Nucleotide-binding domain	Nucleotide-binding domain	1	1
C-terminal domain of alpha and beta subunits of F1 ATP synthase	Cytochrome c oxidase subunit II-like, transmembrane region	1	1
TGS-like	ACT-like	1	1
SAM/Pointed domain	Metallo-hydrolase/oxidoreductase	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	1	1
FYVE/PHD zinc finger	F-box domain	1	1
SAP domain	Domain of poly(ADP-ribose) polymerase	1	1
Acyl-CoA N-acyltransferases (Nat)	RNA-binding domain, RBD	1	1
Putative cyclase	YjgF-like	1	1
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
TPR-like	RNA-binding domain, RBD	1	1
Phage fibre proteins	Ankyrin repeat	1	1
Acetyl-CoA synthetase-like	Tetracyclin repressor-like, C-terminal domain	1	1
FAD/NAD(P)-binding domain	"Winged helix" DNA-binding domain	1	1
WD40 repeat-like	Galactose oxidase, central domain	1	1
Nucleotidyltransferase	ACT-like	1	1
Photosystem II reaction center protein K, PsbK	Photosystem II reaction center protein I, PsbI	1	1
P-loop containing nucleoside triphosphate hydrolases	Ribonuclease Rh-like	1	1
UBA-like	post-AAA+ oligomerization domain-like	1	1
beta-beta-alpha zinc fingers	Ankyrin repeat	1	1
ARM repeat	alpha/beta knot	1	1
Zn-dependent exopeptidases	NAC domain	1	1
L domain-like	ARM repeat	1	1
Putative isomerase YbhE	ARM repeat	1	1
Arabinanase/levansucrase/invertase	Nucleotide-diphospho-sugar transferases	1	1
Myosin S1 fragment, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
DNA repair protein MutS, domain III	SMR domain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	1	1
Metallo-dependent phosphatases	Metallo-dependent phosphatases	1	1
RING/U-box	Leucine zipper domain	1	1
Metalloproteases ("zincins"), catalytic domain	ARM repeat	1	1
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	1	1
Metallo-dependent hydrolases	Metallo-dependent hydrolases	1	1
Ubiquitin-like	HAD-like	1	1
MHC antigen-recognition domain	ARM repeat	1	1
NAD(P)-binding Rossmann-fold domains	DNA/RNA polymerases	1	1
PIN domain-like	Nucleic acid-binding proteins	1	1
ISP domain	Chlorophyll a-b binding protein	1	1
POZ domain	WD40 repeat-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	PLP-dependent transferases	1	1
F-box domain	Glutathione synthetase ATP-binding domain-like	1	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
L domain-like	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
Trigger factor ribosome-binding domain	Triger factor/SurA peptide-binding domain-like	1	1
NusB-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
F-box domain	NTF2-like	1	1
WD40 repeat-like	Peptidase/esterase 'gauge' domain	1	1
TGS-like	Class II aaRS and biotin synthetases	1	1
HydA/Nqo6-like	Nqo5-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Cna protein B-type domain	Cna protein B-type domain	1	1
RuBisCO, large subunit, small (N-terminal) domain	Ribosomal protein S8	1	1
Phosphofructokinase	P-loop containing nucleoside triphosphate hydrolases	1	1
L domain-like	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
ARM repeat	BEACH domain	1	1
Staphylococcal nuclease	Tudor/PWWP/MBT	1	1
Rad51 N-terminal domain-like	ARM repeat	1	1
Leukotriene A4 hydrolase N-terminal domain	ARM repeat	1	1
Metallo-hydrolase/oxidoreductase	alpha/beta-Hydrolases	1	1
F-box domain	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
EF-hand	TPR-like	1	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	Cupredoxins	1	1
Eukaryotic RPB5 N-terminal domain	Eukaryotic RPB5 N-terminal domain	1	1
Rhodanese/Cell cycle control phosphatase	alpha/beta-Hydrolases	1	1
RNA-binding domain, RBD	ENTH/VHS domain	1	1
FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	1	1
Kix domain of CBP (creb binding protein)	Protein kinase-like (PK-like)	1	1
Putative isomerase YbhE	RING/U-box	1	1
WD40 repeat-like	3-carboxy-cis,cis-mucoante lactonizing enzyme	1	1
dsRNA-binding domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	tRNA-binding arm	1	1
HCP-like	Phospholipase D/nuclease	1	1
P-loop containing nucleoside triphosphate hydrolases	Cytochrome c oxidase subunit II-like, transmembrane region	1	1
Type II DNA topoisomerase	GyrA/ParC C-terminal domain-like	1	1
Ubiquitin-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain III	1	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	1	1
SAP domain	CCCH zinc finger	1	1
Leucine zipper domain	Leucine zipper domain	1	1
HCP-like	Argininosuccinate synthetase, C-terminal domain	1	1
GST C-terminal domain-like	Nucleic acid-binding proteins	1	1
"Winged helix" DNA-binding domain	DNA-binding pseudobarrel domain	1	1
CBS-domain pair	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	RNA-binding domain, RBD	1	1
Mog1p/PsbP-like	CRAL/TRIO domain	1	1
Thiolase-like	WD40 repeat-like	1	1
Lipoxigenase	Metal cation-transporting ATPase, ATP-binding domain N	1	1
Protein kinase-like (PK-like)	Class II aaRS and biotin synthetases	1	1
Cysteine proteinases	Thioredoxin-like	1	1
Protein kinase-like (PK-like)	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
Cna protein B-type domain	Carboxypeptidase regulatory domain-like	1	1
Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	1	1
Zn-dependent exopeptidases	L domain-like	1	1
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	1	1
"Winged helix" DNA-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Band 7/SPFH domain	Band 7/SPFH domain	1	1
Cyclin-like	P-loop containing nucleoside triphosphate hydrolases	1	1
HMG-box	Leucine zipper domain	1	1
SSo0622-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Protein kinase-like (PK-like)	NTF2-like	1	1
RNI-like	alpha/beta-Hydrolases	1	1
UBC-like	Class II aaRS and biotin synthetases	1	1
Nucleic acid-binding proteins	Protein kinase-like (PK-like)	1	1
Toll/Interleukin receptor TIR domain	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
Cap-Gly domain	L domain-like	1	1
DNA primase core	P-loop containing nucleoside triphosphate hydrolases	1	1
Rudiment single hybrid motif	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
Chromo domain-like	Ankyrin repeat	1	1
NAC domain	NAC domain	1	1
"Winged helix" DNA-binding domain	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
Arabinanase/levansucrase/invertase	Arabinanase/levansucrase/invertase	1	1
Caspase-like	DNase I-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	YgbK-like	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Acyl-CoA dehydrogenase C-terminal domain-like	Thioesterase/thiol ester dehydrase-isomerase	1	1
Ribokinase-like	Thiamin phosphate synthase	1	1
Ankyrin repeat	S-adenosyl-L-methionine-dependent methyltransferases	1	1
GYF domain	RNA-binding domain, RBD	1	1
Lipocalins	Lipocalins	1	1
WD40 repeat-like	TPR-like	1	1
PA domain	EGF/Laminin	1	1
SWIB/MDM2 domain	eIF1-like	1	1
Second domain of FERM	Prismane protein-like	1	1
Sec1/munc18-like (SM) proteins	Sec1/munc18-like (SM) proteins	1	1
gp5 N-terminal domain-like	alpha/beta-Hydrolases	1	1
Serpins	P-loop containing nucleoside triphosphate hydrolases	1	1
ARM repeat	FabD/lysophospholipase-like	1	1
Starch-binding domain-like	Glutathione synthetase ATP-binding domain-like	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	Clavaminate synthase-like	1	1
Acetyl-CoA synthetase-like	Heme-dependent catalase-like	1	1
MIT domain	MIT domain	1	1
Homeodomain-like	F-box domain	1	1
WD40 repeat-like	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
Adenine nucleotide alpha hydrolases-like	Molybdenum cofactor biosynthesis proteins	1	1
ACP-like	ACP-like	1	1
FAD/NAD(P)-binding domain	Nucleic acid-binding proteins	1	1
Carbamate kinase-like	Acyl-CoA N-acyltransferases (Nat)	1	1
HIT/MYND zinc finger-like	L domain-like	1	1
Cyclin-like	L domain-like	1	1
Subtilisin-like	Cytidine deaminase-like	1	1
ARM repeat	Ribosomal protein L4	1	1
Kix domain of CBP (creb binding protein)	Kix domain of CBP (creb binding protein)	1	1
Ankyrin repeat	RCC1/BLIP-II	1	1
N-utilization substance G protein NusG, N-terminal domain	Translation proteins SH3-like domain	1	1
TK C-terminal domain-like	NAD(P)-binding Rossmann-fold domains	1	1
RNA-binding domain, RBD	N-terminal domain of alpha and beta subunits of F1 ATP synthase	1	1
Tex N-terminal region-like	RuvA domain 2-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	alpha-helical ferredoxin	1	1
Cytochrome P450	Calcium-dependent phosphotriesterase	1	1
Acetyl-CoA synthetase-like	Homeodomain-like	1	1
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	1	1
Tricorn protease domain 2	alpha/beta-Hydrolases	1	1
HCP-like	RNI-like	1	1
5' to 3' exonuclease, C-terminal subdomain	Chromo domain-like	1	1
Quinoprotein alcohol dehydrogenase-like	DPP6 N-terminal domain-like	1	1
TK C-terminal domain-like	HAD-like	1	1
L domain-like	V-type ATP synthase subunit C	1	1
Homeodomain-like	TATA-box binding protein-like	1	1
Carbohydrate phosphatase	TK C-terminal domain-like	1	1
Phage tail proteins	alpha/beta-Hydrolases	1	1
WGR domain-like	NAD(P)-binding Rossmann-fold domains	1	1
RNI-like	SGNH hydrolase	1	1
CBS-domain pair	FAD-binding/transporter-associated domain-like	1	1
Protein kinase-like (PK-like)	Acyl-CoA dehydrogenase NM domain-like	1	1
Cullin repeat-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
AF0104/ALDC/Ptd012-like	AF0104/ALDC/Ptd012-like	1	1
C-terminal UvrC-binding domain of UvrB	ApaG-like	1	1
DNA breaking-rejoining enzymes	Heat shock protein 70kD (HSP70), peptide-binding domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	1	1
JAB1/MPN domain	cAMP-binding domain-like	1	1
Six-hairpin glycosidases	Tautomerase/MIF	1	1
Carbamate kinase-like	Carbamate kinase-like	1	1
Tudor/PWWP/MBT	Tudor/PWWP/MBT	1	1
Metallo-hydrolase/oxidoreductase	Casein kinase II beta subunit	1	1
DEK C-terminal domain	SWIB/MDM2 domain	1	1
F-box domain	Calcium-dependent phosphotriesterase	1	1
HMA, heavy metal-associated domain	FAD/NAD(P)-binding domain	1	1
R3H domain	P-loop containing nucleoside triphosphate hydrolases	1	1
FMN-linked oxidoreductases	alpha-helical ferredoxin	1	1
ALDH-like	TPR-like	1	1
Sec1/munc18-like (SM) proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
Ribosomal protein S8	RuBisCo, C-terminal domain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Protein kinase-like (PK-like)	1	1
alpha/beta-Hydrolases	Ankyrin repeat	1	1
ARID-like	Homeodomain-like	1	1
Tudor/PWWP/MBT	P-loop containing nucleoside triphosphate hydrolases	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	Homeodomain-like	1	1
ALDH-like	ALDH-like	1	1
HIT/MYND zinc finger-like	SET domain	1	1
"Winged helix" DNA-binding domain	Periplasmic binding protein-like II	1	1
POZ domain	Quinoprotein alcohol dehydrogenase-like	1	1
Tex N-terminal region-like	Nucleic acid-binding proteins	1	1
PH domain-like	(Phosphotyrosine protein) phosphatases II	1	1
UBA-like	NSFL1 (p97 ATPase) cofactor p47, SEP domain	1	1
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	1	1
Alpha subunit of glutamate synthase, C-terminal domain	alpha-helical ferredoxin	1	1
RNI-like	WD40 repeat-like	1	1
Ribosomal protein S2	F1F0 ATP synthase subunit A	1	1
P-loop containing nucleoside triphosphate hydrolases	Cupredoxins	1	1
WD40 repeat-like	Toll/Interleukin receptor TIR domain	1	1
P-loop containing nucleoside triphosphate hydrolases	PLP-dependent transferases	1	1
Pseudouridine synthase	PUA domain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FAD/NAD(P)-binding domain	1	1
NAD(P)-binding Rossmann-fold domains	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
RNI-like	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
Acid proteases	Nucleic acid-binding proteins	1	1
Photosystem II antenna protein-like	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	1	1
Prokaryotic type I DNA topoisomerase	Retrovirus zinc finger-like domains	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	GHMP Kinase, C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	UBC-like	1	1
Thiamin diphosphate-binding fold (THDP-binding)	HAD-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Retrovirus zinc finger-like domains	1	1
F-box domain	Outer arm dynein light chain 1	1	1
Taf5 N-terminal domain-like	WD40 repeat-like	1	1
PreATP-grasp domain	ClpP/crotonase	1	1
lambda repressor-like DNA-binding domains	Cyanase C-terminal domain	1	1
HMA, heavy metal-associated domain	NosL/MerB-like	1	1
Cryptochrome/photolyase, N-terminal domain	alpha/beta-Hydrolases	1	1
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	1	1
MurE/MurF N-terminal domain	MurD-like peptide ligases, catalytic domain	1	1
Periplasmic binding protein-like I	Periplasmic binding protein-like I	1	1
Bromodomain	Nucleic acid-binding proteins	1	1
GroES-like	DNA/RNA polymerases	1	1
DPP6 N-terminal domain-like	HCP-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Methyl-accepting chemotaxis protein (MCP) signaling domain	1	1
beta-sandwich domain of Sec23/24	Acid proteases	1	1
ssDNA-binding transcriptional regulator domain	ssDNA-binding transcriptional regulator domain	1	1
L domain-like	DNA-binding pseudobarrel domain	1	1
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	1	1