Domain combination pairs in Nematostella vectensis 1.0

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

2334 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
EGF/Laminin	EGF/Laminin	220	100
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	190	48
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	136	53
Immunoglobulin	Immunoglobulin	120	61
Galactose-binding domain-like	Galactose-binding domain-like	98	22
Nicotinic receptor ligand binding domain-like	Neurotransmitter-gated ion-channel transmembrane pore	91	3
EGF/Laminin	Growth factor receptor domain	89	66
TSP-1 type 1 repeat	TSP-1 type 1 repeat	86	25
TPR-like	TPR-like	83	28
Growth factor receptor domain	Growth factor receptor domain	64	47
RING/U-box	B-box zinc-binding domain	61	15
Cadherin-like	Cadherin-like	49	30
P-loop containing nucleoside triphosphate hydrolases	ABC transporter transmembrane region	49	9
Voltage-gated potassium channels	Voltage-gated potassium channels	44	11
POZ domain	Voltage-gated potassium channels	43	5
RNA-binding domain, RBD	RNA-binding domain, RBD	43	20
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	43	17
Actin-like ATPase domain	Actin-like ATPase domain	41	11
POZ domain	Kelch motif	40	8
ARM repeat	ARM repeat	40	24
Spermadhesin, CUB domain	Spermadhesin, CUB domain	39	20
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	34	25
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	32	16
Immunoglobulin	Fibronectin type III	32	26
Fibronectin type III	Fibronectin type III	31	27
EF-hand	EF-hand	31	17
LDL receptor-like module	LDL receptor-like module	30	15
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	30	3
ABC transporter transmembrane region	ABC transporter transmembrane region	29	6
DBL homology domain (DH-domain)	PH domain-like	28	19
RING/U-box	TRAF domain-like	28	14
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	27	11
Hairpin loop containing domain-like	Fibrinogen C-terminal domain-like	27	10
SRCR-like	SRCR-like	27	9
Concanavalin A-like lectins/glucanases	EGF/Laminin	27	24
CalX-like	CalX-like	26	16
F-box domain	RNI-like	26	9
WD40 repeat-like	WD40 repeat-like	26	15
Homeodomain-like	Homeodomain-like	25	16
B-box zinc-binding domain	E set domains	25	12
Thioredoxin-like	GST C-terminal domain-like	25	2
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	23	10
Complement control module/SCR domain	Complement control module/SCR domain	22	16
Ubiquitin-like	Second domain of FERM	21	12
Ubiquitin-like	PH domain-like	21	13
PH domain-like	Second domain of FERM	21	13
Kazal-type serine protease inhibitors	Kazal-type serine protease inhibitors	21	10
RING/U-box	RING/U-box	21	14
RNI-like	RNI-like	21	8
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	21	2
Glutathione synthetase ATP-binding domain-like	PreATP-grasp domain	20	14
EGF/Laminin	Galactose-binding domain-like	20	14
HAD-like	Calcium ATPase, transmembrane domain M	20	6
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	19	4
Calcium ATPase, transduction domain A	HAD-like	19	5
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	19	5
Thioredoxin-like	Thioredoxin-like	19	11
cAMP-binding domain-like	Voltage-gated potassium channels	19	9
PH domain-like	PH domain-like	19	16
vWA-like	vWA-like	19	13
Protein kinase-like (PK-like)	ARM repeat	18	13
Metalloproteases ("zincins"), catalytic domain	TSP-1 type 1 repeat	18	15
Glucocorticoid receptor-like (DNA-binding domain)	Nuclear receptor ligand-binding domain	18	3
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	18	6
RING/U-box	E set domains	18	8
Voltage-gated potassium channels	Periplasmic binding protein-like II	18	7
Zn-dependent exopeptidases	Transferrin receptor-like dimerisation domain	17	2
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	17	3
MFS general substrate transporter	MFS general substrate transporter	17	5
TRAF domain-like	TRAF domain-like	17	9
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	17	3
GroEL equatorial domain-like	GroEL apical domain-like	17	4
L domain-like	Family A G protein-coupled receptor-like	17	6
E set domains	NHL repeat	17	8
EGF/Laminin	Fibrinogen C-terminal domain-like	17	8
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	17	3
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	16	9
Actin depolymerizing proteins	Actin depolymerizing proteins	16	12
SH3-domain	SH3-domain	16	12
Thyroglobulin type-1 domain	Thyroglobulin type-1 domain	16	3
PA domain	Zn-dependent exopeptidases	16	2
Cyclin-like	Cyclin-like	16	4
Hairpin loop containing domain-like	EGF/Laminin	16	11
Spectrin repeat	Spectrin repeat	16	16
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	16	6
FYVE/PHD zinc finger	FYVE/PHD zinc finger	16	12
PDZ domain-like	PDZ domain-like	16	14
PGBD-like	Metalloproteases ("zincins"), catalytic domain	15	5
PA domain	Transferrin receptor-like dimerisation domain	15	1
Metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	15	10
Cadherin-like	EGF/Laminin	15	11
B-box zinc-binding domain	NHL repeat	15	6
Kelch motif	Kelch motif	15	8
Thiolase-like	Thiolase-like	14	2
RING/U-box	NHL repeat	14	5
GroEL equatorial domain-like	GroEL-intermediate domain like	14	3
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	14	6
BAR/IMD domain-like	SH3-domain	14	8
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	14	5
cAMP-binding domain-like	cAMP-binding domain-like	14	8
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	13	4
Tudor/PWWP/MBT	Tudor/PWWP/MBT	13	12
(Trans)glycosidases	Glycosyl hydrolase domain	13	6
Family A G protein-coupled receptor-like	Family A G protein-coupled receptor-like	13	6
GroES-like	NAD(P)-binding Rossmann-fold domains	13	1
GroEL-intermediate domain like	GroEL apical domain-like	13	2
EGF/Laminin	YWTD domain	13	11
Pentapeptide repeat-like	Pentapeptide repeat-like	12	7
SH3-domain	PH domain-like	12	12
Guanido kinase N-terminal domain	Glutamine synthetase/guanido kinase	12	4
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	12	10
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	12	12
Ubiquitin-like	Ubiquitin-like	12	11
Hairpin loop containing domain-like	Concanavalin A-like lectins/glucanases	12	5
WD40 repeat-like	Quinoprotein alcohol dehydrogenase-like	11	10
F-box domain	WD40 repeat-like	11	6
Nucleic acid-binding proteins	Nucleic acid-binding proteins	11	10
Protein kinase-like (PK-like)	Nucleotide cyclase	11	3
C-type lectin-like	C-type lectin-like	11	8
E set domains	E set domains	11	10
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	11	3
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	11	5
Galactose-binding domain-like	(Trans)glycosidases	11	5
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	10	7
Fibronectin type III	Voltage-gated potassium channels	10	10
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	10	5
P-loop containing nucleoside triphosphate hydrolases	DEATH domain	10	10
CoA-dependent acyltransferases	CoA-dependent acyltransferases	10	2
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	10	3
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	10	5
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	10	2
PreATP-grasp domain	Rudiment single hybrid motif	10	7
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	10	4
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	10	4
Histone-fold	Histone-fold	10	2
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	9	7
WW domain	WW domain	9	8
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	9	4
Subtilisin-like	Galactose-binding domain-like	9	4
POZ domain	POZ domain	9	7
L domain-like	L domain-like	9	8
SH3-domain	P-loop containing nucleoside triphosphate hydrolases	9	9
GTPase activation domain, GAP	PH domain-like	9	8
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	9	4
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	9	6
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	9	5
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	9	7
Periplasmic binding protein-like I	Periplasmic binding protein-like II	9	7
lambda repressor-like DNA-binding domains	Homeodomain-like	9	2
P-loop containing nucleoside triphosphate hydrolases	TPR-like	9	7
Protease propeptides/inhibitors	Subtilisin-like	9	4
SET domain	beta-beta-alpha zinc fingers	8	5
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	8	7
Ubiquitin-like	UBA-like	8	8
P-loop containing nucleoside triphosphate hydrolases	SMAD/FHA domain	8	6
Concanavalin A-like lectins/glucanases	C-type lectin-like	8	7
Concanavalin A-like lectins/glucanases	Fibronectin type III	8	7
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	8	8
Calponin-homology domain, CH-domain	Spectrin repeat	8	8
FYVE/PHD zinc finger	Bromodomain	8	6
EF-hand	PLC-like phosphodiesterases	8	8
HLH, helix-loop-helix DNA-binding domain	PYP-like sensor domain (PAS domain)	8	6
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	8	8
RNI-like	EF-hand	8	4
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	8	2
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	8	2
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	8	3
MFS general substrate transporter	Kazal-type serine protease inhibitors	8	2
Metalloproteases ("zincins"), catalytic domain	Concanavalin A-like lectins/glucanases	8	2
Spermadhesin, CUB domain	EGF/Laminin	8	8
PHM/PNGase F	PHM/PNGase F	8	3
Hairpin loop containing domain-like	Galactose-binding domain-like	8	5
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	8	5
Purple acid phosphatase, N-terminal domain	Metallo-dependent phosphatases	8	3
LDL receptor-like module	YWTD domain	8	8
DNA/RNA polymerases	Ribonuclease H-like	8	7
TPR-like	HCP-like	8	8
DEATH domain	DEATH domain	7	7
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	7	4
Galactose oxidase, central domain	Kelch motif	7	4
PDZ domain-like	SH3-domain	7	7
Invertebrate chitin-binding proteins	Invertebrate chitin-binding proteins	7	7
TSP-1 type 1 repeat	Fibronectin type III	7	7
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	7	4
BRCT domain	BRCT domain	7	7
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	7	4
Kazal-type serine protease inhibitors	EF-hand	7	5
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	7	3
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	7	4
Periplasmic binding protein-like I	Growth factor receptor domain	7	3
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	7	6
RING/U-box	WD40 repeat-like	7	5
Complement control module/SCR domain	EGF/Laminin	7	7
EGF/Laminin	LDL receptor-like module	7	7
Cadherin-like	Concanavalin A-like lectins/glucanases	7	7
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	7	4
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	7	3
Protease propeptides/inhibitors	Galactose-binding domain-like	7	2
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	7	5
Cullin homology domain	"Winged helix" DNA-binding domain	7	3
vWA-like	EGF/Laminin	7	5
PH domain-like	(Phosphotyrosine protein) phosphatases II	7	5
Cysteine-rich domain	Cysteine-rich domain	7	6
Insect cysteine-rich antifreeze protein	Insect cysteine-rich antifreeze protein	7	4
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	7	5
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	7	2
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	6	2
Rudiment single hybrid motif	Single hybrid motif	6	3
Cullin repeat-like	"Winged helix" DNA-binding domain	6	2
PH domain-like	PDZ domain-like	6	6
Cullin repeat-like	Cullin homology domain	6	2
Galactose-binding domain-like	Fibronectin type III	6	6
PH domain-like	SH2 domain	6	4
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	6	3
Ligand-binding domain in the NO signalling and Golgi transport	Nucleotide cyclase	6	2
SH3-domain	DBL homology domain (DH-domain)	6	6
Growth factor receptor domain	YWTD domain	6	6
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	6	3
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	6	2
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	6	4
Glucocorticoid receptor-like (DNA-binding domain)	Homeodomain-like	6	4
PreATP-grasp domain	Single hybrid motif	6	3
HLH, helix-loop-helix DNA-binding domain	Orange domain-like	6	3
Cysteine-rich domain	Protein kinase-like (PK-like)	6	5
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	6	5
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	6	5
Nucleotide cyclase	EAL domain-like	6	3
EF-G C-terminal domain-like	EF-G C-terminal domain-like	6	5
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	6	5
dsRNA-binding domain-like	dsRNA-binding domain-like	6	6
P-loop containing nucleoside triphosphate hydrolases	RNI-like	6	5
BEACH domain	WD40 repeat-like	6	5
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	6	6
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	6	3
L domain-like	Growth factor receptor domain	6	5
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	6	3
"Winged helix" DNA-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	6	1
Ubiquitin-like	PDZ domain-like	6	6
Periplasmic binding protein-like I	Protein kinase-like (PK-like)	6	5
PKD domain	PKD domain	6	6
PAZ domain	Ribonuclease H-like	6	4
GAF domain-like	GAF domain-like	6	4
L27 domain	PDZ domain-like	6	6
POZ domain	Galactose oxidase, central domain	6	3
FAS1 domain	FAS1 domain	6	5
PH domain-like	FYVE/PHD zinc finger	6	6
PDZ domain-like	P-loop containing nucleoside triphosphate hydrolases	6	6
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	6	4
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	6	1
WD40 repeat-like	ARM repeat	6	6
ArfGap/RecO-like zinc finger	PH domain-like	6	6
Concanavalin A-like lectins/glucanases	Growth factor receptor domain	6	6
RING/U-box	Cysteine proteinases	6	5
Folate-binding domain	Aminomethyltransferase beta-barrel domain	5	3
Integrin domains	EGF/Laminin	5	3
Rhodanese/Cell cycle control phosphatase	(Phosphotyrosine protein) phosphatases II	5	1
DUSP-like	Cysteine proteinases	5	5
DEATH domain	TPR-like	5	5
Spectrin repeat	EF-hand	5	5
CHY zinc finger-like	Zinc hairpin stack	5	5
Ubiquitin-like	Cysteine proteinases	5	4
FYVE/PHD zinc finger	DNase I-like	5	3
DEATH domain	Caspase-like	5	4
SAM/Pointed domain	SAM/Pointed domain	5	4
LDL receptor-like module	Growth factor receptor domain	5	5
(Trans)glycosidases	Chitinase insertion domain	5	1
Ankyrin repeat	ARM repeat	5	5
Voltage-gated potassium channels	E set domains	5	3
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	5	2
Concanavalin A-like lectins/glucanases	Galactose-binding domain-like	5	5
PX domain	BAR/IMD domain-like	5	2
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	5	4
PH domain-like	PLC-like phosphodiesterases	5	5
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	5	3
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	5	5
WD40 repeat-like	SOCS box-like	5	3
Protein kinase-like (PK-like)	P-loop containing nucleoside triphosphate hydrolases	5	5
Plexin repeat	vWA-like	5	3
C2 domain (Calcium/lipid-binding domain, CaLB)	GTPase activation domain, GAP	5	5
C-type lectin-like	Galactose-binding domain-like	5	5
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	5	5
Fibronectin type III	Protein kinase-like (PK-like)	5	5
vWA-like	Integrin domains	5	3
Protease propeptides/inhibitors	Zn-dependent exopeptidases	5	2
Translation proteins	EF-G C-terminal domain-like	5	4
HMG-box	HMG-box	5	3
Cysteine-rich domain	C2 domain (Calcium/lipid-binding domain, CaLB)	5	4
"Winged helix" DNA-binding domain	Periplasmic binding protein-like II	5	1
Galactose-binding domain-like	Growth factor receptor domain	5	5
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	5	5
Cysteine-rich domain	PH domain-like	5	5
Plexin repeat	Integrin domains	5	3
Complement control module/SCR domain	Growth factor receptor domain	5	5
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	5	1
Metalloproteases ("zincins"), catalytic domain	Blood coagulation inhibitor (disintegrin)	5	2
Fibrinogen C-terminal domain-like	Fibrinogen C-terminal domain-like	5	3
t-snare proteins	SNARE fusion complex	5	3
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	5	1
GAF domain-like	HD-domain/PDEase-like	5	3
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	5	5
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	5	5
Spermadhesin, CUB domain	Growth factor receptor domain	5	5
PH domain-like	BEACH domain	5	3
Spermadhesin, CUB domain	Concanavalin A-like lectins/glucanases	5	5
Metalloproteases ("zincins"), catalytic domain	Hemopexin-like domain	5	3
Plexin repeat	EGF/Laminin	5	3
PH domain-like	EF-hand	5	5
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	5	3
Metalloproteases ("zincins"), catalytic domain	Metalloproteases ("zincins"), catalytic domain	5	4
Flavoproteins	Riboflavin synthase domain-like	5	4
POZ domain	Ankyrin repeat	4	4
Ankyrin repeat	P-loop containing nucleoside triphosphate hydrolases	4	4
Doublecortin (DC)	Doublecortin (DC)	4	4
Translation proteins	Ribosomal protein S5 domain 2-like	4	3
YWTD domain	YWTD domain	4	4
Nucleoside diphosphate kinase, NDK	Nucleoside diphosphate kinase, NDK	4	3
Clc chloride channel	CBS-domain pair	4	4
Ankyrin repeat	SH3-domain	4	3
Chromo domain-like	Chromo domain-like	4	3
FAD-linked reductases, C-terminal domain	Aminomethyltransferase beta-barrel domain	4	2
P-loop containing nucleoside triphosphate hydrolases	PH domain-like	4	4
RING/U-box	UBA-like	4	4
SMAD MH1 domain	SMAD/FHA domain	4	2
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	4	4
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	4	2
P-loop containing nucleoside triphosphate hydrolases	Concanavalin A-like lectins/glucanases	4	2
Ubiquitin-like	Thioredoxin-like	4	4
Oxidoreductase molybdopterin-binding domain	E set domains	4	2
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	4	2
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	4	4
Protein kinase-like (PK-like)	SAM/Pointed domain	4	3
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	cAMP-binding domain-like	4	1
Protein kinase-like (PK-like)	SH3-domain	4	4
CCCH zinc finger	RING/U-box	4	4
BAR/IMD domain-like	GTPase activation domain, GAP	4	4
Clavaminate synthase-like	FYVE/PHD zinc finger	4	4
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	4	2
SH2 domain	SH3-domain	4	4
SH3-domain	PX domain	4	3
RING/U-box	TPR-like	4	3
ClpP/crotonase	ClpP/crotonase	4	2
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	4	3
ARM repeat	"Winged helix" DNA-binding domain	4	1
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	4	4
Ubiquitin-like	Protein kinase-like (PK-like)	4	4
ARM repeat	Formin homology 2 domain (FH2 domain)	4	3
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	4	3
PH domain-like	Ras GEF	4	4
L27 domain	SH3-domain	4	4
Periplasmic binding protein-like I	Periplasmic binding protein-like I	4	4
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	4	4
DNase I-like	DNase I-like	4	4
Pectin lyase-like	Pectin lyase-like	4	4
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	4	3
EF-hand	Cysteine proteinases	4	2
WD40 repeat-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	4	4
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	4	4
Toll/Interleukin receptor TIR domain	Toll/Interleukin receptor TIR domain	4	3
Adhesin YadA, collagen-binding domain	Adhesin YadA, collagen-binding domain	4	1
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	4	4
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	4	4
EF-hand	Mitochondrial carrier	4	2
Cytochrome b5-like heme/steroid binding domain	Oxidoreductase molybdopterin-binding domain	4	2
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipase/lipooxygenase domain (PLAT/LH2 domain)	4	3
C2 domain (Calcium/lipid-binding domain, CaLB)	vWA-like	4	1
Nucleotide cyclase	Nucleotide cyclase	4	3
P-loop containing nucleoside triphosphate hydrolases	RING/U-box	4	3
FAD-linked reductases, C-terminal domain	Folate-binding domain	4	2
Immunoglobulin	Protein kinase-like (PK-like)	4	3
SH2 domain	SOCS box-like	4	1
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	4	3
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	4	4
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	4	4
SNARE-like	SNARE fusion complex	4	2
Carbamoyl phosphate synthetase, large subunit connection domain	PreATP-grasp domain	4	4
Cysteine proteinases	FYVE/PHD zinc finger	4	3
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	4	1
Cytochrome b5-like heme/steroid binding domain	E set domains	4	2
EGF/Laminin	TB module/8-cys domain	4	4
Phage fibre proteins	Phage fibre proteins	4	3
TSP type-3 repeat	Concanavalin A-like lectins/glucanases	4	4
Myosin S1 fragment, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	4	4
PH domain-like	ARM repeat	4	4
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	4	3
Snake toxin-like	Protein kinase-like (PK-like)	4	1
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	4	2
RCC1/BLIP-II	Hect, E3 ligase catalytic domain	4	4
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	4	4
E set domains	(Trans)glycosidases	4	4
Sec7 domain	PH domain-like	4	3
TSP-1 type 1 repeat	Voltage-gated potassium channels	4	4
L27 domain	P-loop containing nucleoside triphosphate hydrolases	4	4
EF-hand	WD40 repeat-like	4	4
PH domain-like	Ankyrin repeat	4	4
Hairpin loop containing domain-like	Hairpin loop containing domain-like	4	4
Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	4	3
PH domain-like	WD40 repeat-like	4	3
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	4	3
Ankyrin repeat	Ankyrin repeat	4	4
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	4	4
P-loop containing nucleoside triphosphate hydrolases	Myosin rod fragments	4	4
Galactose-binding domain-like	Immunoglobulin	4	4
TPR-like	"Winged helix" DNA-binding domain	4	1
Complement control module/SCR domain	Concanavalin A-like lectins/glucanases	4	4
FAD/NAD(P)-binding domain	Folate-binding domain	4	2
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	4	4
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	4	4
Metalloproteases ("zincins"), catalytic domain	ARM repeat	4	2
BAR/IMD domain-like	PH domain-like	4	4
Restriction endonuclease-like	FYVE/PHD zinc finger	4	3
FAD/NAD(P)-binding domain	Aminomethyltransferase beta-barrel domain	4	2
Spectrin repeat	PH domain-like	4	4
Chondroitin AC/alginate lyase	Galactose mutarotase-like	4	3
Kringle-like	Kringle-like	4	1
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	4	2
PR-1-like	PR-1-like	4	4
TSP type-3 repeat	TSP type-3 repeat	4	4
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	4	4
Ubiquitin-like	ARM repeat	4	3
Concanavalin A-like lectins/glucanases	RING/U-box	4	3
PriA/YqbF domain	GINS helical bundle-like	4	2
Somatomedin B domain	Family A G protein-coupled receptor-like	4	3
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	4	4
RING/U-box	Calcium-dependent phosphotriesterase	3	3
Acetyl-CoA synthetase-like	Acetyl-CoA synthetase-like	3	3
Ubiquitin-like	Ras GEF	3	3
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	3
Plexin repeat	Integrin beta tail domain	3	2
WD40 repeat-like	TPR-like	3	3
Thiolase-like	FabD/lysophospholipase-like	3	1
Galactose mutarotase-like	Glycosyl hydrolase domain	3	1
post-HMGL domain-like	Single hybrid motif	3	1
CCCH zinc finger	CCCH zinc finger	3	3
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	3	2
L domain-like	Immunoglobulin	3	3
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	3	1
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	3	3
B-box zinc-binding domain	Fibronectin type III	3	2
Glucocorticoid receptor-like (DNA-binding domain)	SH3-domain	3	1
PurM N-terminal domain-like	PurM C-terminal domain-like	3	3
Aconitase iron-sulfur domain	LeuD/IlvD-like	3	1
Nucleic acid-binding proteins	Translation proteins SH3-like domain	3	2
alpha/beta-Hydrolases	Galactose-binding domain-like	3	2
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	3	1
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	3	3
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	3	3
Calpain large subunit, middle domain (domain III)	EF-hand	3	1
Translation proteins	Initiation factor IF2/eIF5b, domain 3	3	2
Amine oxidase N-terminal region	Amine oxidase catalytic domain	3	2
TPR-like	Clavaminate synthase-like	3	2
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	3	3
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	3	3
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	3	1
Cysteine-rich domain	GTPase activation domain, GAP	3	3
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains	Multidrug efflux transporter AcrB transmembrane domain	3	2
Zn-finger domain of Sec23/24	beta-sandwich domain of Sec23/24	3	3
Glutathione synthetase ATP-binding domain-like	post-HMGL domain-like	3	1
Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	3	1
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	3	2
beta-N-acetylhexosaminidase-like domain	E set domains	3	3
RNA-binding domain, RBD	Retrovirus zinc finger-like domains	3	1
MgtE N-terminal domain-like	MgtE N-terminal domain-like	3	3
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	3	2
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	3	3
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	3	3
WD40 repeat-like	FYVE/PHD zinc finger	3	2
SNARE fusion complex	SNARE fusion complex	3	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Nucleotidyltransferase substrate binding subunit/domain	3	3
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	3	3
Protein kinase-like (PK-like)	Polo-box domain	3	2
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	3	1
FKBP-like	EF-hand	3	1
Immunoglobulin	Complement control module/SCR domain	3	3
Translation proteins	Translation proteins	3	2
Succinyl-CoA synthetase domains	NAD(P)-binding Rossmann-fold domains	3	2
ARM repeat	Cysteine proteinases	3	3
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	3	2
RING/U-box	Fibronectin type III	3	2
Protein kinase-like (PK-like)	WD40 repeat-like	3	3
Glutathione synthetase ATP-binding domain-like	Aldolase	3	1
RuvA domain 2-like	Ribonuclease H-like	3	3
Ribonuclease H-like	Ribonuclease H-like	3	2
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	3	3
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	3	3
Guanido kinase N-terminal domain	Guanido kinase N-terminal domain	3	2
EGF/Laminin	Integrin beta tail domain	3	2
WGR domain-like	Domain of poly(ADP-ribose) polymerase	3	3
Ubiquitin-like	Ankyrin repeat	3	3
ARM repeat	Clathrin adaptor appendage domain	3	2
Nucleotidylyl transferase	P-loop containing nucleoside triphosphate hydrolases	3	3
Galactose-binding domain-like	SEA domain	3	3
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	3
Actin depolymerizing proteins	VHP, Villin headpiece domain	3	3
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	3	2
P-loop containing nucleoside triphosphate hydrolases	TGS-like	3	1
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	3	1
Aldolase	post-HMGL domain-like	3	1
alpha-catenin/vinculin-like	alpha-catenin/vinculin-like	3	3
E set domains	Cysteine proteinases	3	2
Ubiquitin-like	RING/U-box	3	3
FnI-like domain	FnI-like domain	3	3
HIT/MYND zinc finger-like	SET domain	3	3
SEA domain	Fibronectin type III	3	3
Concanavalin A-like lectins/glucanases	SRCR-like	3	3
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	3	3
Zinc beta-ribbon	Cyclin-like	3	3
Zinc hairpin stack	RING/U-box	3	3
Spermadhesin, CUB domain	Immunoglobulin	3	3
p53-like transcription factors	E set domains	3	3
Growth factor receptor domain	SEA domain	3	2
P-loop containing nucleoside triphosphate hydrolases	EF-hand	3	3
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	3	3
SGNH hydrolase	DNase I-like	3	2
Integrin domains	Integrin beta tail domain	3	2
PYP-like sensor domain (PAS domain)	Voltage-gated potassium channels	3	2
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	3	2
Saposin	Saposin	3	2
vWA-like	Complement control module/SCR domain	3	3
PGBD-like	Hemopexin-like domain	3	2
Toll/Interleukin receptor TIR domain	SAM/Pointed domain	3	2
PreATP-grasp domain	Methylglyoxal synthase-like	3	3
UBC-like	RING/U-box	3	2
Nucleotide-binding domain	Nucleotide-binding domain	3	2
Calponin-homology domain, CH-domain	EF-hand	3	3
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	3	2
Cap-Gly domain	Cysteine proteinases	3	2
PYP-like sensor domain (PAS domain)	cAMP-binding domain-like	3	2
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	3	2
FYVE/PHD zinc finger	RING/U-box	3	3
FKBP-like	TPR-like	3	3
PreATP-grasp domain	Aldolase	3	1
P-loop containing nucleoside triphosphate hydrolases	POZ domain	3	1
C2 domain (Calcium/lipid-binding domain, CaLB)	ARM repeat	3	3
TSP-1 type 1 repeat	EGF/Laminin	3	3
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	3	3
Rudiment single hybrid motif	post-HMGL domain-like	3	1
Elafin-like	Elafin-like	3	3
Calponin-homology domain, CH-domain	E set domains	3	3
Amine oxidase N-terminal region	Amine oxidase N-terminal region	3	2
Regulator of G-protein signaling, RGS	PX domain	3	2
Concanavalin A-like lectins/glucanases	SEA domain	3	3
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	3	3
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	3	2
vWA-like	Helical domain of Sec23/24	3	3
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	3	3
Galactose-binding domain-like	vWA-like	3	3
vWA-like	Integrin beta tail domain	3	2
Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	3	2
SNF-like	SNF-like	3	1
RCC1/BLIP-II	RCC1/BLIP-II	3	3
Bromodomain	Bromodomain	3	3
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	3	3
HIT/MYND zinc finger-like	TPR-like	3	3
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	3	2
Cysteine-rich domain	Ubiquitin-like	3	3
Calponin-homology domain, CH-domain	Calponin-homology domain, CH-domain	3	3
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	3	3
Formyltransferase	FMT C-terminal domain-like	3	2
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	3	2
Rudiment single hybrid motif	Aldolase	3	1
Protein kinase-like (PK-like)	DEATH domain	3	3
ARM repeat	TPR-like	3	3
SAM/Pointed domain	RING/U-box	3	3
EGF/Laminin	C-type lectin-like	3	3
Protein kinase-like (PK-like)	RCC1/BLIP-II	3	2
Immunoglobulin	Family A G protein-coupled receptor-like	3	3
CHY zinc finger-like	RING/U-box	3	3
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	3	1
Sec63 N-terminal domain-like	E set domains	3	2
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	3	2
Single hybrid motif	CoA-dependent acyltransferases	3	1
Zn-finger domain of Sec23/24	vWA-like	3	3
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	3	1
vWA-like	beta-sandwich domain of Sec23/24	3	3
P-loop containing nucleoside triphosphate hydrolases	Retrovirus zinc finger-like domains	3	3
PreATP-grasp domain	post-HMGL domain-like	3	1
ARM repeat	Subdomain of clathrin and coatomer appendage domain	3	2
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	3	3
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	3	2
Galactose-binding domain-like	Hect, E3 ligase catalytic domain	3	3
Leukotriene A4 hydrolase N-terminal domain	ARM repeat	3	1
GTPase activation domain, GAP	SH3-domain	3	3
ArfGap/RecO-like zinc finger	Ankyrin repeat	3	3
ARM repeat	Concanavalin A-like lectins/glucanases	3	3
Galactose-binding domain-like	Protein kinase-like (PK-like)	3	3
UBA-like	UBA-like	3	3
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	3	1
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	3	2
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	3
FYVE/PHD zinc finger	Tudor/PWWP/MBT	3	3
PH domain-like	Oxysterol-binding protein-like	3	2
ENTH/VHS domain	GAT-like domain	3	2
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	3	2
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	3	1
Aldolase	Single hybrid motif	3	1
Cytidine deaminase-like	Cytidine deaminase-like	3	2
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	3	3
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	3	2
FYVE/PHD zinc finger	"Winged helix" DNA-binding domain	3	3
PUA domain-like	RING/U-box	3	3
Galactose mutarotase-like	(Trans)glycosidases	3	1
EF-hand	RING/U-box	3	3
vWA-like	Concanavalin A-like lectins/glucanases	3	3
Homeodomain-like	RING/U-box	3	3
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	3	3
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	3	3
Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	2	2
F-box domain	Concanavalin A-like lectins/glucanases	2	2
Polo-box domain	Polo-box domain	2	1
Regulator of G-protein signaling, RGS	Protein kinase-like (PK-like)	2	1
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	2	1
cAMP-binding domain-like	Protein kinase-like (PK-like)	2	2
PsbU/PolX domain-like	Nucleotidyltransferase	2	2
Protein kinase-like (PK-like)	Acyl-CoA dehydrogenase C-terminal domain-like	2	2
WD40 repeat-like	Cyclophilin-like	2	1
PreATP-grasp domain	Metallo-dependent hydrolases	2	2
P-loop containing nucleoside triphosphate hydrolases	PUA domain-like	2	2
Ubiquitin-like	RNI-like	2	2
Restriction endonuclease-like	RuvA domain 2-like	2	2
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	2	2
Growth factor receptor domain	Cadherin-like	2	2
Kringle-like	Protein kinase-like (PK-like)	2	2
SH2 domain	GTPase activation domain, GAP	2	2
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	2	2
Ubiquitin-like	"Winged helix" DNA-binding domain	2	2
Periplasmic binding protein-like II	MetI-like	2	2
Tudor/PWWP/MBT	P-loop containing nucleoside triphosphate hydrolases	2	2
P-loop containing nucleoside triphosphate hydrolases	Microbial and mitochondrial ADK, insert "zinc finger" domain	2	2
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	2	2
Integrin alpha N-terminal domain	Integrin domains	2	2
C-type lectin-like	Hairpin loop containing domain-like	2	2
Protein kinase-like (PK-like)	PX domain	2	2
Immunoglobulin	Concanavalin A-like lectins/glucanases	2	2
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	2	1
Tex N-terminal region-like	RuvA domain 2-like	2	2
Lipase/lipooxygenase domain (PLAT/LH2 domain)	EGF/Laminin	2	2
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	2	2
Immunoglobulin	DNase I-like	2	2
F-box domain	Pectin lyase-like	2	2
P-loop containing nucleoside triphosphate hydrolases	E set domains	2	1
UBA-like	Hect, E3 ligase catalytic domain	2	2
Tropomyosin	Smc hinge domain	2	2
R3H domain	Ribonuclease H-like	2	2
EGF/Laminin	Trypsin-like serine proteases	2	2
Phospholipase D/nuclease	Phospholipase D/nuclease	2	2
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	1
NAD(P)-binding Rossmann-fold domains	DHS-like NAD/FAD-binding domain	2	1
PreATP-grasp domain	Composite domain of metallo-dependent hydrolases	2	2
Ankyrin repeat	Protein kinase-like (PK-like)	2	2
Methylglyoxal synthase-like	Metallo-dependent hydrolases	2	2
SET domain	RuBisCo LSMT C-terminal, substrate-binding domain	2	2
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	2	2
Metallo-dependent phosphatases	Metallo-dependent phosphatases	2	1
CAD & PB1 domains	Protein kinase-like (PK-like)	2	2
TNF receptor-like	DEATH domain	2	1
P-loop containing nucleoside triphosphate hydrolases	RNA-binding domain, RBD	2	2
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	2	2
Concanavalin A-like lectins/glucanases	LDL receptor-like module	2	2
Cadherin-like	Dystroglycan, domain 2	2	2
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	2	2
Kelch motif	EGF/Laminin	2	2
Protein kinase-like (PK-like)	KA1-like	2	2
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	2	2
Concanavalin A-like lectins/glucanases	Voltage-gated potassium channels	2	2
Nucleotidylyl transferase	Ribosomal protein L25-like	2	2
Protein kinase-like (PK-like)	UBA-like	2	2
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	2	2
Restriction endonuclease-like	Cysteine proteinases	2	1
Nucleic acid-binding proteins	TPR-like	2	2
DEATH domain	Toll/Interleukin receptor TIR domain	2	2
Eukaryotic type KH-domain (KH-domain type I)	Tudor/PWWP/MBT	2	2
C-type lectin-like	SEA domain	2	2
Immunoglobulin	Caspase-like	2	2
Class I glutamine amidotransferase-like	P-loop containing nucleoside triphosphate hydrolases	2	2
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	2	2
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	2	2
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	2	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	1
MIR domain	MIR domain	2	2
Methylglyoxal synthase-like	Cytidine deaminase-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	2	1
CheY-like	P-loop containing nucleoside triphosphate hydrolases	2	2
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	2	2
Thioredoxin-like	ERP29 C domain-like	2	1
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	2
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	2	2
Class I glutamine amidotransferase-like	Glutathione synthetase ATP-binding domain-like	2	2
MIR domain	IP3 receptor type 1 binding core, domain 2	2	2
Growth factor receptor domain	TB module/8-cys domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Second domain of FERM	2	2
Homodimeric domain of signal transducing histidine kinase	CheY-like	2	2
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	2	1
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	2	2
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	2	2
FAS1 domain	EGF/Laminin	2	2
SMAD/FHA domain	SMAD/FHA domain	2	2
Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	2	2
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	2	2
Concanavalin A-like lectins/glucanases	TSP-1 type 1 repeat	2	2
Translation proteins	ThrRS/AlaRS common domain	2	2
EF-hand	Cysteine-rich domain	2	2
Taf5 N-terminal domain-like	WD40 repeat-like	2	2
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	2	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	2	2
HMA, heavy metal-associated domain	HAD-like	2	2
RNA-binding domain, RBD	L domain-like	2	2
MurCD N-terminal domain	MurD-like peptide ligases, catalytic domain	2	2
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	2	1
UBA-like	RNA-binding domain, RBD	2	2
Growth factor receptor domain	SRCR-like	2	2
PX domain	Outer arm dynein light chain 1	2	1
Barwin-like endoglucanases	Barwin-like endoglucanases	2	2
Myosin rod fragments	Myosin rod fragments	2	2
WWE domain	Hect, E3 ligase catalytic domain	2	2
Ubiquitin-like	Moesin tail domain	2	1
CAD & PB1 domains	UBA-like	2	2
Immunoglobulin	C-type lectin-like	2	2
SAM/Pointed domain	HD-domain/PDEase-like	2	2
DBL homology domain (DH-domain)	GTPase activation domain, GAP	2	2
Growth factor receptor domain	Fibronectin type III	2	2
Thioredoxin-like	beta-beta-alpha zinc fingers	2	2
Galactose-binding domain-like	Chondroitin AC/alginate lyase	2	2
Carbamate kinase-like	ALDH-like	2	1
Glutaminase/Asparaginase	Ankyrin repeat	2	1
PABC (PABP) domain	PABC (PABP) domain	2	2
BRCT domain	Homeodomain-like	2	2
Second domain of FERM	Moesin tail domain	2	1
PDZ domain-like	"Winged helix" DNA-binding domain	2	2
Tryptophan synthase beta subunit-like PLP-dependent enzymes	CBS-domain pair	2	1
UBC-like	UBA-like	2	2
MOSC N-terminal domain-like	PK beta-barrel domain-like	2	1
RNA-binding domain, RBD	dsRNA-binding domain-like	2	2
Carbamoyl phosphate synthetase, large subunit connection domain	Metallo-dependent hydrolases	2	2
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	2	1
Ubiquitin-like	DBL homology domain (DH-domain)	2	2
Ubiquitin-like	Ran binding protein zinc finger-like	2	2
TRAF domain-like	WD40 repeat-like	2	2
PH domain-like	"Winged helix" DNA-binding domain	2	2
ARM repeat	P-loop containing nucleoside triphosphate hydrolases	2	2
TSP-1 type 1 repeat	Galactose-binding domain-like	2	2
FMN-linked oxidoreductases	alpha-helical ferredoxin	2	2
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	2	2
Methyl-accepting chemotaxis protein (MCP) signaling domain	Methyl-accepting chemotaxis protein (MCP) signaling domain	2	2
Class I glutamine amidotransferase-like	Carbamoyl phosphate synthetase, large subunit connection domain	2	2
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	2	1
Ypt/Rab-GAP domain of gyp1p	RUN domain-like	2	2
RuvA domain 2-like	Nucleic acid-binding proteins	2	2
Sema domain	Plexin repeat	2	2
TRAF domain-like	POZ domain	2	2
FLJ32549 domain-like	FLJ32549 domain-like	2	1
E set domains	Pectin lyase-like	2	2
EGF/Laminin	Fibronectin type III	2	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	2	2
beta-lactamase/transpeptidase-like	beta-lactamase/transpeptidase-like	2	2
WD40 repeat-like	NHL repeat	2	2
Metalloproteases ("zincins"), catalytic domain	Spermadhesin, CUB domain	2	2
cAMP-binding domain-like	Ubiquitin-like	2	2
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	2	2
AN1-like Zinc finger	AN1-like Zinc finger	2	2
Tex N-terminal region-like	Nucleic acid-binding proteins	2	2
Tropomyosin	Tropomyosin	2	2
L domain-like	RNI-like	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheY-like	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	2	2
CBD9-like	PHM/PNGase F	2	1
Nucleotidylyl transferase	S15/NS1 RNA-binding domain	2	2
Complement control module/SCR domain	Trypsin-like serine proteases	2	2
Calponin-homology domain, CH-domain	DBL homology domain (DH-domain)	2	2
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	2	1
Ribosomal L27 protein-like	Nucleic acid-binding proteins	2	2
Growth factor receptor domain	Mannose 6-phosphate receptor domain	2	2
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	2	1
TB module/8-cys domain	TB module/8-cys domain	2	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	2	2
Chaperone J-domain	RNA-binding domain, RBD	2	2
RCC1/BLIP-II	POZ domain	2	2
Mib/herc2 domain-like	Hect, E3 ligase catalytic domain	2	2
Ankyrin repeat	SAM/Pointed domain	2	2
DBL homology domain (DH-domain)	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	2	2
E set domains	Calcium-dependent phosphotriesterase	2	2
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	2	2
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	2	1
Lipovitellin-phosvitin complex, superhelical domain	Lipovitellin-phosvitin complex; beta-sheet shell regions	2	2
Calponin-homology domain, CH-domain	PH domain-like	2	2
Terpenoid cyclases/Protein prenyltransferases	Alpha-macroglobulin receptor domain	2	2
WW domain	Hect, E3 ligase catalytic domain	2	2
SRCR-like	L domain-like	2	2
PYP-like sensor domain (PAS domain)	Homodimeric domain of signal transducing histidine kinase	2	2
Glutathione synthetase ATP-binding domain-like	Composite domain of metallo-dependent hydrolases	2	2
B-box zinc-binding domain	P-loop containing nucleoside triphosphate hydrolases	2	1
TATA-box binding protein-like	DNA-glycosylase	2	1
Spectrin repeat	SH3-domain	2	2
Tex N-terminal region-like	Ribonuclease H-like	2	2
C2 domain (Calcium/lipid-binding domain, CaLB)	WW domain	2	2
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	2	2
alpha-helical ferredoxin	Nucleotide-binding domain	2	2
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	2	2
ARM repeat	Hect, E3 ligase catalytic domain	2	2
Phage tail proteins	Phage tail proteins	2	2
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	2	2
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	2	2
Mib/herc2 domain-like	RING/U-box	2	2
Carbamoyl phosphate synthetase, large subunit connection domain	Composite domain of metallo-dependent hydrolases	2	2
HlyD-like secretion proteins	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	2	2
Enolase N-terminal domain-like	Enolase C-terminal domain-like	2	1
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	2
PreATP-grasp domain	PreATP-grasp domain	2	2
ALDH-like	ALDH-like	2	1
Second domain of FERM	Second domain of FERM	2	2
PDZ domain-like	Second domain of FERM	2	2
Ankyrin repeat	RING/U-box	2	1
HCP-like	HCP-like	2	2
WW domain	EF-hand	2	2
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	2	2
F-box domain	Sec7 domain	2	1
Metalloproteases ("zincins"), catalytic domain	EGF/Laminin	2	2
Ubiquitin-like	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
P-loop containing nucleoside triphosphate hydrolases	CarD-like	2	2
Trefoil	Trefoil	2	2
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	2	2
Kringle-like	Galactose-binding domain-like	2	2
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	2	1
Carbohydrate-binding domain	(Trans)glycosidases	2	2
CRAL/TRIO domain	DBL homology domain (DH-domain)	2	2
PDZ domain-like	WW domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Glucocorticoid receptor-like (DNA-binding domain)	2	1
PH domain-like	Protein kinase-like (PK-like)	2	2
Cyclophilin-like	RNA-binding domain, RBD	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	2
Spectrin repeat	DBL homology domain (DH-domain)	2	2
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	2	1
Carbohydrate-binding domain	E set domains	2	2
Thyroglobulin type-1 domain	EF-hand	2	2
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	2	2
Carbohydrate-binding domain	beta-N-acetylhexosaminidase-like domain	2	2
Frizzled cysteine-rich domain	TIMP-like	2	1
PLP-binding barrel	Alanine racemase C-terminal domain-like	2	1
ARID-like	Clavaminate synthase-like	2	2
Barwin-like endoglucanases	Invertebrate chitin-binding proteins	2	2
Calponin-homology domain, CH-domain	GAS2 domain-like	2	1
Ribonuclease H-like	Nucleic acid-binding proteins	2	2
Nucleic acid-binding proteins	eIF2alpha middle domain-like	2	1
Chaperone J-domain	Homeodomain-like	2	1
CAD & PB1 domains	RING/U-box	2	2
CalX-like	Concanavalin A-like lectins/glucanases	2	2
cAMP-binding domain-like	Ras GEF	2	2
Cytokine	Cytokine	2	2
Sec7 domain	ARM repeat	2	2
CRAL/TRIO domain	Spectrin repeat	2	2
CheY-like	C-terminal effector domain of the bipartite response regulators	2	1
C2 domain (Calcium/lipid-binding domain, CaLB)	FabD/lysophospholipase-like	2	2
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	2	2
NAD(P)-binding Rossmann-fold domains	P-loop containing nucleoside triphosphate hydrolases	2	2
Formate/glycerate dehydrogenase catalytic domain-like	DHS-like NAD/FAD-binding domain	2	1
Acetyl-CoA synthetase-like	ACP-like	2	2
Ankyrin repeat	Ras GEF	2	2
WGR domain-like	ADP-ribosylation	2	2
SH3-domain	EF-hand	2	2
Voltage-gated potassium channels	EF-hand	2	2
Class I glutamine amidotransferase-like	PreATP-grasp domain	2	2
Family A G protein-coupled receptor-like	alpha/beta-Hydrolases	2	2
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	2	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	PreATP-grasp domain	2	2
Homeodomain-like	FAD/NAD(P)-binding domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	2	1
MIT domain	Protein kinase-like (PK-like)	2	2
RNase III domain-like	dsRNA-binding domain-like	2	2
Spermadhesin, CUB domain	LDL receptor-like module	2	2
SAM/Pointed domain	PH domain-like	2	2
ADC-like	Cdc48 domain 2-like	2	1
Immunoglobulin	Toll/Interleukin receptor TIR domain	2	2
Chaperone J-domain	Thioredoxin-like	2	2
Protein kinase-like (PK-like)	Acyl-CoA dehydrogenase NM domain-like	2	2
"Winged helix" DNA-binding domain	E set domains	2	1
F-box domain	L domain-like	2	2
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	2	2
Galactose-binding domain-like	Galactose mutarotase-like	2	2
Glutathione synthetase ATP-binding domain-like	Metallo-dependent hydrolases	2	2
Class II aaRS and biotin synthetases	ThrRS/AlaRS common domain	2	2
Hedgehog/DD-peptidase	Hedgehog/intein (Hint) domain	2	1
PH domain-like	Moesin tail domain	2	1
DBL homology domain (DH-domain)	WD40 repeat-like	2	2
FMN-linked oxidoreductases	Nucleotide-binding domain	2	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	2	2
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	2	2
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	2	2
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	2	2
Galactose-binding domain-like	Mib/herc2 domain-like	2	2
NAD(P)-binding Rossmann-fold domains	SCP-like	2	2
SH2 domain	Ubiquitin-like	2	2
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	2	2
cAMP-binding domain-like	"Winged helix" DNA-binding domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	2	2
Immunoglobulin	tRNA-intron endonuclease catalytic domain-like	2	2
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	2	1
Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	2	2
FLJ32549 domain-like	FLJ32549 C-terminal domain-like	2	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	2	2
Cysteine proteinases	Cysteine proteinases	2	2
Galactose-binding domain-like	Complement control module/SCR domain	2	2
Metalloproteases ("zincins"), catalytic domain	Fibronectin type III	2	2
L domain-like	ARM repeat	2	2
Translational machinery components	L30e-like	2	2
Integrin domains	Integrin domains	2	2
Granulin repeat	Granulin repeat	2	2
C-type lectin-like	Family A G protein-coupled receptor-like	2	1
Zinc beta-ribbon	Zinc beta-ribbon	2	1
TPR-like	SET domain	2	2
L domain-like	P-loop containing nucleoside triphosphate hydrolases	2	2
SH2 domain	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
BAR/IMD domain-like	Cysteine-rich domain	2	2
lambda integrase-like, N-terminal domain	DNA breaking-rejoining enzymes	2	2
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	2	2
FYVE/PHD zinc finger	Family A G protein-coupled receptor-like	2	2
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	2	1
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	2	1
Protein kinase-like (PK-like)	NTF2-like	2	1
ADC-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Cap-Gly domain	Cap-Gly domain	2	2
(Trans)glycosidases	EGF/Laminin	2	2
Spermadhesin, CUB domain	Galactose-binding domain-like	2	2
B-box zinc-binding domain	Calcium-dependent phosphotriesterase	2	2
SAP domain	Restriction endonuclease-like	2	1
Trypsin-like serine proteases	PDZ domain-like	2	2
Immunoglobulin	EGF/Laminin	2	2
Ypt/Rab-GAP domain of gyp1p	Rhodanese/Cell cycle control phosphatase	2	2
A DNA-binding domain in eukaryotic transcription factors	Leucine zipper domain	2	2
Immunoglobulin	TSP-1 type 1 repeat	2	2
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	2	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Carbamoyl phosphate synthetase, large subunit connection domain	2	2
Mitochondrial carrier	Pentapeptide repeat-like	2	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Glutathione synthetase ATP-binding domain-like	2	2
CRAL/TRIO domain	PH domain-like	2	2
Spermadhesin, CUB domain	Kelch motif	2	2
DEATH domain	Immunoglobulin	2	2
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	2	2
PX domain	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
Methylglyoxal synthase-like	Composite domain of metallo-dependent hydrolases	2	2
Homeodomain-like	FAD-linked reductases, C-terminal domain	2	2
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	2	2
ARM repeat	Toll/Interleukin receptor TIR domain	2	2
Globin-like	Globin-like	2	2
RuvA domain 2-like	RuvA domain 2-like	2	2
Cysteine proteinases	UBA-like	2	2
RUN domain-like	PH domain-like	2	2
Phosphoenolpyruvate/pyruvate domain	Thioesterase/thiol ester dehydrase-isomerase	2	2
Inosine monophosphate dehydrogenase (IMPDH)	Inosine monophosphate dehydrogenase (IMPDH)	2	1
Galactose oxidase, central domain	Galactose oxidase, central domain	2	2
B-box zinc-binding domain	Concanavalin A-like lectins/glucanases	2	1
Growth factor receptor domain	Fibrinogen C-terminal domain-like	2	2
R3H domain	P-loop containing nucleoside triphosphate hydrolases	2	2
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	2	2
Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	2	2
Second domain of FERM	RING/U-box	2	2
GTPase activation domain, GAP	RGC domain-like	2	2
DNase I-like	Family A G protein-coupled receptor-like	2	2
Molybdenum cofactor biosynthesis proteins	MoeA N-terminal region -like	1	1
Phage fibre proteins	(Phosphotyrosine protein) phosphatases II	1	1
EGF/Laminin	Lipoxigenase	1	1
Ribulose-phoshate binding barrel	all-alpha NTP pyrophosphatases	1	1
BRCT domain	Domain of poly(ADP-ribose) polymerase	1	1
FMT C-terminal domain-like	ALDH-like	1	1
RNA-binding domain, RBD	Clavaminate synthase-like	1	1
Phage tail proteins	gp5 N-terminal domain-like	1	1
Phosphofructokinase	Phosphofructokinase	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	1	1
STAT	SH2 domain	1	1
Tudor/PWWP/MBT	SET domain	1	1
Kringle-like	Concanavalin A-like lectins/glucanases	1	1
Ubiquitin-like	Hect, E3 ligase catalytic domain	1	1
Hairpin loop containing domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Regulator of G-protein signaling, RGS	Ubiquitin-like	1	1
Anthrax protective antigen	Voltage-gated potassium channels	1	1
Spermadhesin, CUB domain	Complement control module/SCR domain	1	1
Hormone receptor domain	Family A G protein-coupled receptor-like	1	1
Pentapeptide repeat-like	DNase I-like	1	1
Hypothetical protein c14orf129, hspc210	ARM repeat	1	1
SMAD/FHA domain	PDZ domain-like	1	1
Ankyrin repeat	PDZ domain-like	1	1
Nitric oxide (NO) synthase oxygenase domain	Flavoproteins	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	1	1
NHL repeat	BPTI-like	1	1
L domain-like	Fibronectin type III	1	1
Terpenoid cyclases/Protein prenyltransferases	TIMP-like	1	1
MIT domain	MIT domain	1	1
Cysteine proteinases	HIT/MYND zinc finger-like	1	1
Mib/herc2 domain-like	UBA-like	1	1
Concanavalin A-like lectins/glucanases	FYVE/PHD zinc finger	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
Agglutinin HPA-like	Kazal-type serine protease inhibitors	1	1
Multidrug efflux transporter AcrB transmembrane domain	WD40 repeat-like	1	1
Thioredoxin-like	eEF1-gamma domain	1	1
Porins	P-loop containing nucleoside triphosphate hydrolases	1	1
Thiolase-like	SCP-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Phospholipase A2, PLA2	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex; beta-sheet shell regions	1	1
PUG domain-like	Galactose-binding domain-like	1	1
Metalloproteases ("zincins"), catalytic domain	Complement control module/SCR domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	VPS9 domain	1	1
F-box domain	RING/U-box	1	1
WD40 repeat-like	DPP6 N-terminal domain-like	1	1
dsRNA-binding domain-like	R3H domain	1	1
vWA-like	Immunoglobulin	1	1
ARM repeat	SAM/Pointed domain	1	1
GST C-terminal domain-like	S15/NS1 RNA-binding domain	1	1
Thioredoxin-like	DnaJ/Hsp40 cysteine-rich domain	1	1
Urease, gamma-subunit	Urease, beta-subunit	1	1
Serine protease inhibitors	Serine protease inhibitors	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
TSP-1 type 1 repeat	DEATH domain	1	1
PH domain-like	BSD domain-like	1	1
Growth factor receptor domain	Notch domain	1	1
ACT-like	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
HAMP domain-like	Nucleotide cyclase	1	1
Amyloid beta a4 protein copper binding domain (domain 2)	CAPPD, an extracellular domain of amyloid beta A4 protein	1	1
FYVE/PHD zinc finger	PUA domain-like	1	1
L domain-like	PDZ domain-like	1	1
Cytochrome b5-like heme/steroid binding domain	Riboflavin synthase domain-like	1	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
Putative DNA-binding domain	Putative DNA-binding domain	1	1
Hypothetical protein c14orf129, hspc210	TPR-like	1	1
BRCT domain	ADP-ribosylation	1	1
FYVE/PHD zinc finger	SET domain	1	1
Adenine nucleotide alpha hydrolases-like	Type II DNA topoisomerase	1	1
V-type ATP synthase subunit C	Thioesterase/thiol ester dehydrase-isomerase	1	1
Alkaline phosphatase-like	His-Me finger endonucleases	1	1
Eukaryotic type KH-domain (KH-domain type I)	LigT-like	1	1
RNA-binding domain, RBD	Ran binding protein zinc finger-like	1	1
Tropomyosin	RNI-like	1	1
GroEL apical domain-like	SAICAR synthase-like	1	1
Rudiment single hybrid motif	PurM C-terminal domain-like	1	1
Actin-like ATPase domain	CV3147-like	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
L domain-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	1	1
Fibrinogen C-terminal domain-like	Fibronectin type III	1	1
PUG domain-like	Ran binding protein zinc finger-like	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	Pyrimidine nucleoside phosphorylase C-terminal domain	1	1
Chaperone J-domain	UBA-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Family A G protein-coupled receptor-like	1	1
vWA-like	SRCR-like	1	1
Calponin-homology domain, CH-domain	P-loop containing nucleoside triphosphate hydrolases	1	1
L domain-like	DNase I-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	1	1
NAD kinase/diacylglycerol kinase-like	CheY-like	1	1
PTPA-like	PTPA-like	1	1
RNI-like	Phospholipase A2, PLA2	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
CCCH zinc finger	RNA-binding domain, RBD	1	1
Microbial and mitochondrial ADK, insert "zinc finger" domain	Microbial and mitochondrial ADK, insert "zinc finger" domain	1	1
FMN-linked oxidoreductases	Galactose-binding domain-like	1	1
PLC-like phosphodiesterases	C-terminal domain of PLC-beta	1	1
Tricorn protease domain 2	TPR-like	1	1
Clavaminate synthase-like	Tudor/PWWP/MBT	1	1
Formyltransferase	ALDH-like	1	1
Thioredoxin-like	Nucleoside diphosphate kinase, NDK	1	1
cAMP-binding domain-like	FabD/lysophospholipase-like	1	1
GST C-terminal domain-like	C-terminal domain of ProRS	1	1
CBS-domain pair	MgtE membrane domain-like	1	1
PDZ domain-like	Cysteine-rich domain	1	1
FYVE/PHD zinc finger	S-adenosyl-L-methionine-dependent methyltransferases	1	1
SPOC domain-like	SAP domain	1	1
Ubiquitin-like	SMAD/FHA domain	1	1
Multidrug efflux transporter AcrB transmembrane domain	DNA breaking-rejoining enzymes	1	1
EGF/Laminin	Invertebrate chitin-binding proteins	1	1
Trimeric LpxA-like enzymes	ARM repeat	1	1
HAD-like	alpha/beta-Hydrolases	1	1
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	1	1
GAT-like domain	Clathrin adaptor appendage domain	1	1
RING/U-box	RNA-binding domain, RBD	1	1
Seven-hairpin glycosidases	Seven-hairpin glycosidases	1	1
EGF/Laminin	TIMP-like	1	1
RCC1/BLIP-II	Galactose-binding domain-like	1	1
A middle domain of Talin 1	alpha-catenin/vinculin-like	1	1
PYP-like sensor domain (PAS domain)	HD-domain/PDEase-like	1	1
Fibrinogen C-terminal domain-like	Galactose-binding domain-like	1	1
PDZ domain-like	EF-hand	1	1
UBA-like	Galactose-binding domain-like	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	1	1
Concanavalin A-like lectins/glucanases	FnI-like domain	1	1
YjgF-like	YjgF-like	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
CheY-like	Nucleotidyltransferase	1	1
TAFH domain-like	HIT/MYND zinc finger-like	1	1
alpha/beta-Hydrolases	alpha/beta-Hydrolases	1	1
Putative DNA-binding domain	SAND domain-like	1	1
Putative DNA-binding domain	PheT/TilS domain	1	1
PUA domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, dispensable insert domain	1	1
Thioredoxin-like	NHL repeat	1	1
Glucocorticoid receptor-like (DNA-binding domain)	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
DNase I-like	RNA-binding domain, RBD	1	1
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	1	1
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	1	1
Tropomyosin	Class II aaRS ABD-related	1	1
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains	1	1
E set domains	Transglutaminase, two C-terminal domains	1	1
TPR-like	PIN domain-like	1	1
Tudor/PWWP/MBT	CCHHC domain	1	1
RNA-binding domain, RBD	ENTH/VHS domain	1	1
GMP synthetase C-terminal dimerisation domain	GMP synthetase C-terminal dimerisation domain	1	1
Apolipoprotein A-I	NHL repeat	1	1
N-terminal domain of MutM-like DNA repair proteins	Glucocorticoid receptor-like (DNA-binding domain)	1	1
"Winged helix" DNA-binding domain	Regulator of G-protein signaling, RGS	1	1
EAL domain-like	Composite domain of metallo-dependent hydrolases	1	1
SAP domain	SAP domain	1	1
WD40 repeat-like	TolB, C-terminal domain	1	1
ACT-like	ACT-like	1	1
CRAL/TRIO domain	PapD-like	1	1
ENTH/VHS domain	SH3-domain	1	1
tRNA-binding arm	Class II aaRS and biotin synthetases	1	1
Nitrite and sulphite reductase 4Fe-4S domain-like	Precorrin-8X methylmutase CbiC/CobH	1	1
Concanavalin A-like lectins/glucanases	Serine protease inhibitors	1	1
R3H domain	AN1-like Zinc finger	1	1
PLP-dependent transferases	PreATP-grasp domain	1	1
AbfB domain	Kringle-like	1	1
Glutathione synthetase ATP-binding domain-like	Aspartate/ornithine carbamoyltransferase	1	1
Pentapeptide repeat-like	Concanavalin A-like lectins/glucanases	1	1
Ras GEF	EF-hand	1	1
HCP-like	Cyclin-like	1	1
RNA-binding domain, RBD	NTF2-like	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Voltage-gated potassium channels	1	1
FKBP-like	FKBP-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Periplasmic binding protein-like II	1	1
(Phosphotyrosine protein) phosphatases II	Cysteine-rich domain	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
Myosin S1 fragment, N-terminal domain	Myosin rod fragments	1	1
L domain-like	UBA-like	1	1
RING/U-box	BRCT domain	1	1
TRAF domain-like	Cysteine proteinases	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	ACT-like	1	1
Glutathione synthetase ATP-binding domain-like	PurM N-terminal domain-like	1	1
EGF/Laminin	Thioesterase/thiol ester dehydrase-isomerase	1	1
Thioredoxin-like	Galactose-binding domain-like	1	1
Ras GEF	Cysteine-rich domain	1	1
A middle domain of Talin 1	I/LWEQ domain	1	1
LDL receptor-like module	Fibronectin type III	1	1
DNA polymerase beta, N-terminal domain-like	Restriction endonuclease-like	1	1
SH3-domain	Toll/Interleukin receptor TIR domain	1	1
TROVE domain-like	vWA-like	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	LDL receptor-like module	1	1
Doublecortin (DC)	Ricin B-like lectins	1	1
TAZ domain	TAZ domain	1	1
BRK domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Ubiquitin-like	PUA domain-like	1	1
PurM N-terminal domain-like	Class I glutamine amidotransferase-like	1	1
Calponin-homology domain, CH-domain	ARM repeat	1	1
XRCC4, N-terminal domain	DNase I-like	1	1
Zn-dependent exopeptidases	Zn-dependent exopeptidases	1	1
Ubiquitin-like	alpha-catenin/vinculin-like	1	1
PRTase-like	Ribulose-phoshate binding barrel	1	1
(Trans)glycosidases	(Trans)glycosidases	1	1
Dcp2 domain-like	Nudix	1	1
ARM repeat	Ras GEF	1	1
UBA-like	Peptidyl-tRNA hydrolase II	1	1
Dom34/Pelota N-terminal domain-like	L30e-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	1	1
TAZ domain	Kix domain of CBP (creb binding protein)	1	1
SAP domain	Ribonuclease H-like	1	1
Second domain of FERM	A middle domain of Talin 1	1	1
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	1	1
PDZ domain-like	Concanavalin A-like lectins/glucanases	1	1
Ubiquitin-like	GTPase activation domain, GAP	1	1
EF-hand	Kelch motif	1	1
P-loop containing nucleoside triphosphate hydrolases	EGF/Laminin	1	1
ACT-like	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Methylglyoxal synthase-like	1	1
NAP-like	Ankyrin repeat	1	1
DNA-glycosylase	Nudix	1	1
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	1	1
Restriction endonuclease-like	DEK C-terminal domain	1	1
SMAD/FHA domain	PH domain-like	1	1
RING/U-box	Protein kinase-like (PK-like)	1	1
RNI-like	Toll/Interleukin receptor TIR domain	1	1
Homocysteine S-methyltransferase	Methionine synthase activation domain-like	1	1
RuvA domain 2-like	WD40 repeat-like	1	1
Growth factor receptor domain	Protein kinase-like (PK-like)	1	1
(Trans)glycosidases	Invertebrate chitin-binding proteins	1	1
Porins	Porins	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
PGBD-like	PGBD-like	1	1
Calponin-homology domain, CH-domain	SH2 domain	1	1
MIR domain	ARM repeat	1	1
Cyclophilin-like	TPR-like	1	1
Concanavalin A-like lectins/glucanases	Glucocorticoid receptor-like (DNA-binding domain)	1	1
R3H domain	RNA-binding domain, RBD	1	1
Ribulose-phoshate binding barrel	Periplasmic binding protein-like II	1	1
Arp2/3 complex subunits	Arp2/3 complex subunits	1	1
MIT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Concanavalin A-like lectins/glucanases	Protein kinase-like (PK-like)	1	1
ARM repeat	Tudor/PWWP/MBT	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Type II DNA topoisomerase	1	1
Cap-Gly domain	Protein kinase-like (PK-like)	1	1
Nucleotide cyclase	Metallo-dependent hydrolases	1	1
Hairpin loop containing domain-like	SNARE-like	1	1
HR1 repeat	PDZ domain-like	1	1
Precorrin-8X methylmutase CbiC/CobH	CbiG N-terminal domain-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	S15/NS1 RNA-binding domain	1	1
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	1	1
Pentapeptide repeat-like	Nucleoside diphosphate kinase, NDK	1	1
SMAD/FHA domain	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Sema domain	GTPase activation domain, GAP	1	1
PurS-like	PurM C-terminal domain-like	1	1
beta-beta-alpha zinc fingers	RNA-binding domain, RBD	1	1
Transglutaminase, two C-terminal domains	Transglutaminase, two C-terminal domains	1	1
PK beta-barrel domain-like	PK C-terminal domain-like	1	1
Histone-fold	DBL homology domain (DH-domain)	1	1
Adenine nucleotide alpha hydrolases-like	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	1	1
PP2C-like	Protein serine/threonine phosphatase 2C, C-terminal domain	1	1
Thioredoxin-like	FabD/lysophospholipase-like	1	1
RCC1/BLIP-II	RING/U-box	1	1
RmlC-like cupins	RmlC-like cupins	1	1
Restriction endonuclease-like	SWIB/MDM2 domain	1	1
Quinoprotein alcohol dehydrogenase-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
Outer arm dynein light chain 1	Family A G protein-coupled receptor-like	1	1
Lamin A/C globular tail domain	WD40 repeat-like	1	1
Tudor/PWWP/MBT	Cytokine	1	1
MgtE membrane domain-like	MgtE membrane domain-like	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	UBA-like	1	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	1	1
Ribonuclease H-like	CCCH zinc finger	1	1
RING/U-box	NRDP1 C-terminal domain-like	1	1
WW domain	dsRNA-binding domain-like	1	1
His-Me finger endonucleases	DNA/RNA polymerases	1	1
Actin-crosslinking proteins	Actin-crosslinking proteins	1	1
GST C-terminal domain-like	Class II aaRS ABD-related	1	1
E set domains	Glycosyl hydrolase domain	1	1
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	1	1
Dehydroquinate synthase-like	LysM domain	1	1
Galactose-binding domain-like	BRCT domain	1	1
Acetyl-CoA synthetase-like	Quinoprotein alcohol dehydrogenase-like	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipoxigenase	1	1
DNA primase core	P-loop containing nucleoside triphosphate hydrolases	1	1
UBA-like	Thioredoxin-like	1	1
HLH, helix-loop-helix DNA-binding domain	HMG-box	1	1
XRCC4, N-terminal domain	Immunoglobulin	1	1
ParB/Sulfiredoxin	KorB DNA-binding domain-like	1	1
PUG domain-like	RING/U-box	1	1
Quinoprotein alcohol dehydrogenase-like	Ypt/Rab-GAP domain of gyp1p	1	1
DBL homology domain (DH-domain)	FYVE/PHD zinc finger	1	1
Nucleotidylyl transferase	C-terminal domain of ProRS	1	1
UBC-like	Endosomal sorting complex assembly domain	1	1
Dihydropteroate synthetase-like	Methionine synthase activation domain-like	1	1
(Phosphotyrosine protein) phosphatases II	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
Periplasmic binding protein-like I	Nucleotide cyclase	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Aspartate/ornithine carbamoyltransferase	1	1
Homeodomain-like	TNF-like	1	1
P-loop containing nucleoside triphosphate hydrolases	RuvA domain 2-like	1	1
USP8 N-terminal domain-like	JAB1/MPN domain	1	1
Thioredoxin-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Ubiquitin-like	ADP-ribosylation	1	1
C-terminal, gelsolin-like domain of Sec23/24	VHP, Villin headpiece domain	1	1
HSP20-like chaperones	Riboflavin synthase domain-like	1	1
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	1	1
PLP-dependent transferases	Glutathione synthetase ATP-binding domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Toll/Interleukin receptor TIR domain	1	1
Ribosomal protein S5 domain 2-like	Ribulose-phoshate binding barrel	1	1
P-loop containing nucleoside triphosphate hydrolases	Helical scaffold and wing domains of SecA	1	1
F-box domain	Galactose-binding domain-like	1	1
Calponin-homology domain, CH-domain	Ankyrin repeat	1	1
PIN domain-like	Nucleic acid-binding proteins	1	1
MFS general substrate transporter	Ribulose-phoshate binding barrel	1	1
FYVE/PHD zinc finger	GroEL apical domain-like	1	1
PR-1-like	WD40 repeat-like	1	1
YccV-like	ApaG-like	1	1
MFS general substrate transporter	Ribosomal protein S5 domain 2-like	1	1
Rudiment single hybrid motif	Formyltransferase	1	1
Ypt/Rab-GAP domain of gyp1p	SH3-domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	beta-Roll	1	1
TPR-like	UBA-like	1	1
LDL receptor-like module	Galactose-binding domain-like	1	1
Isocitrate/Isopropylmalate dehydrogenase-like	HlyD-like secretion proteins	1	1
Periplasmic binding protein-like II	Nucleotide cyclase	1	1
P-loop containing nucleoside triphosphate hydrolases	Nucleotidyltransferase	1	1
Macro domain-like	Zn-dependent exopeptidases	1	1
Succinyl-CoA synthetase domains	Citrate synthase	1	1
Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	1	1
F-box domain	YccV-like	1	1
GST C-terminal domain-like	Class II aaRS and biotin synthetases	1	1
MetI-like	MetI-like	1	1
POZ domain	Skp1 dimerisation domain-like	1	1
Family A G protein-coupled receptor-like	ABC transporter transmembrane region	1	1
CRAL/TRIO domain	(Phosphotyrosine protein) phosphatases II	1	1
Ubiquitin-like	A middle domain of Talin 1	1	1
beta-N-acetylhexosaminidase-like domain	Galactose-binding domain-like	1	1
Immunoglobulin	Ribonuclease H-like	1	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Pyrimidine nucleoside phosphorylase C-terminal domain	1	1
vWA-like	Growth factor receptor domain	1	1
Homocysteine S-methyltransferase	Cobalamin (vitamin B12)-binding domain	1	1
RNA-binding domain, RBD	Cysteine proteinases	1	1
Ankyrin repeat	HIT/MYND zinc finger-like	1	1
Thioredoxin-like	FAD/NAD(P)-binding domain	1	1
Adenine nucleotide alpha hydrolases-like	P-loop containing nucleoside triphosphate hydrolases	1	1
beta-beta-alpha zinc fingers	PAP/OAS1 substrate-binding domain	1	1
GST C-terminal domain-like	Ribosomal protein L25-like	1	1
ENTH/VHS domain	FYVE/PHD zinc finger	1	1
TIMP-like	TIMP-like	1	1
3-carboxy-cis,cis-mucoante lactonizing enzyme	EGF/Laminin	1	1
RING/U-box	WWE domain	1	1
P-loop containing nucleoside triphosphate hydrolases	PLC-like phosphodiesterases	1	1
WWE domain	ADP-ribosylation	1	1
Cysteine proteinases	Ankyrin repeat	1	1
Thioesterase/thiol ester dehydrase-isomerase	Bet v1-like	1	1
"Winged helix" DNA-binding domain	PLP-dependent transferases	1	1
EF-hand	Leucine zipper domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	1	1
TATA-box binding protein-like	TATA-box binding protein-like	1	1
RCC1/BLIP-II	Tudor/PWWP/MBT	1	1
SEA domain	Family A G protein-coupled receptor-like	1	1
EGF/Laminin	SEA domain	1	1
p53-like transcription factors	DNA-binding protein LAG-1 (CSL)	1	1
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	1	1
Metalloproteases ("zincins"), catalytic domain	C-type lectin-like	1	1
alpha/beta-Hydrolases	Oligoxyloglucan reducing end-specific cellobiohydrolase	1	1
DBL homology domain (DH-domain)	SGNH hydrolase	1	1
DBL homology domain (DH-domain)	BAR/IMD domain-like	1	1
CBS-domain pair	cAMP-binding domain-like	1	1
PUA domain-like	eIF1-like	1	1
Band 7/SPFH domain	SCP-like	1	1
NAD kinase/diacylglycerol kinase-like	Ankyrin repeat	1	1
Porins	Carboxypeptidase regulatory domain-like	1	1
Homeodomain-like	Nucleotide cyclase	1	1
Nucleic acid-binding proteins	Retrovirus zinc finger-like domains	1	1
Metallo-dependent phosphatases	EF-hand	1	1
Cytochrome b5-like heme/steroid binding domain	Hect, E3 ligase catalytic domain	1	1
L21p-like	L21p-like	1	1
Protein kinase-like (PK-like)	Class II aaRS and biotin synthetases	1	1
Tudor/PWWP/MBT	BRCT domain	1	1
Bacterial hemolysins	RING/U-box	1	1
TSP-1 type 1 repeat	Spermadhesin, CUB domain	1	1
Acyl-CoA binding protein	Ankyrin repeat	1	1
PKD domain	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
Kix domain of CBP (creb binding protein)	RING/U-box	1	1
HR1 repeat	Protein kinase-like (PK-like)	1	1
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	1	1
PH domain-like	A middle domain of Talin 1	1	1
Ankyrin repeat	L domain-like	1	1
TPR-like	HSP20-like chaperones	1	1
PDZ domain-like	Formin homology 2 domain (FH2 domain)	1	1
TPR-like	OmpA-like	1	1
Methylated DNA-protein cysteine methyltransferase domain	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	1	1
EGF/Laminin	TSP type-3 repeat	1	1
CBS-domain pair	Nucleotide-diphospho-sugar transferases	1	1
TSP-1 type 1 repeat	SEA domain	1	1
UBA-like	KA1-like	1	1
PH domain-like	RING/U-box	1	1
Spectrin repeat	GAS2 domain-like	1	1
Alpha-L RNA-binding motif	Pseudouridine synthase	1	1
Growth factor receptor domain	Ankyrin repeat	1	1
DEATH domain	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Chaperone J-domain	E set domains	1	1
F-box domain	Kelch motif	1	1
Ribonuclease H-like	RNA-binding domain, RBD	1	1
Multiheme cytochromes	Family A G protein-coupled receptor-like	1	1
Ypt/Rab-GAP domain of gyp1p	EGF/Laminin	1	1
RNI-like	Galactose-binding domain-like	1	1
Protein kinase-like (PK-like)	FAT domain of focal adhesion kinase	1	1
Starch-binding domain-like	(Phosphotyrosine protein) phosphatases II	1	1
PH domain-like	alpha-catenin/vinculin-like	1	1
ADP-ribosylation	vWA-like	1	1
Phase 1 flagellin	Phase 1 flagellin	1	1
P-loop containing nucleoside triphosphate hydrolases	FF domain	1	1
Homeodomain-like	HAMP domain-like	1	1
CAD & PB1 domains	Cysteine-rich domain	1	1
vWA-like	SAP domain	1	1
RCC1/BLIP-II	PABC (PABP) domain	1	1
Ribonuclease H-like	MFS general substrate transporter	1	1
Concanavalin A-like lectins/glucanases	SOCS box-like	1	1
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	1	1
Bromodomain	HMG-box	1	1
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	1	1
Dihydropteroate synthetase-like	Cobalamin (vitamin B12)-binding domain	1	1
Translation proteins SH3-like domain	Translation proteins SH3-like domain	1	1
EF-hand	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	1	1
Acetyl-CoA synthetase-like	Trimeric LpxA-like enzymes	1	1
Urease, gamma-subunit	Metallo-dependent hydrolases	1	1
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	1	1
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	1	1
WD40 repeat-like	RCC1/BLIP-II	1	1
PH domain-like	Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	1	1
GYF domain	Chaperone J-domain	1	1
ArfGap/RecO-like zinc finger	SH3-domain	1	1
Clavaminate synthase-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	MOP-like	1	1
Cysteine proteinases	Ribonuclease H-like	1	1
Ribonuclease H-like	Fibronectin type III	1	1
Galactose-binding domain-like	Family A G protein-coupled receptor-like	1	1
WD40 repeat-like	Hect, E3 ligase catalytic domain	1	1
PDZ domain-like	(Phosphotyrosine protein) phosphatases II	1	1
SAM/Pointed domain	Ubiquitin-like	1	1
HAMP domain-like	Homodimeric domain of signal transducing histidine kinase	1	1
Second domain of FERM	Protein kinase-like (PK-like)	1	1
Fibronectin type III	(Phosphotyrosine protein) phosphatases II	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
Actin-like ATPase domain	AF1104-like	1	1
Kringle-like	Ricin B-like lectins	1	1
Outer arm dynein light chain 1	L domain-like	1	1
WW domain	FKBP-like	1	1
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	1	1
RING/U-box	ADP-ribosylglycohydrolase	1	1
P-loop containing nucleoside triphosphate hydrolases	Ran binding protein zinc finger-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	HD-domain/PDEase-like	1	1
Glycerol-3-phosphate (1)-acyltransferase	Glycerol-3-phosphate (1)-acyltransferase	1	1
SH3-domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Protein kinase-like (PK-like)	L27 domain	1	1
(Phosphotyrosine protein) phosphatases II	FYVE/PHD zinc finger	1	1
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	1	1
Ubiquitin-like	FAT domain of focal adhesion kinase	1	1
XRCC4, C-terminal oligomerization domain	DNase I-like	1	1
Trypsin-like serine proteases	Trypsin-like serine proteases	1	1
ARM repeat	Mib/herc2 domain-like	1	1
E set domains	GTPase activation domain, GAP	1	1
RAP domain-like	RAP domain-like	1	1
ARM repeat	Family A G protein-coupled receptor-like	1	1
CHY zinc finger-like	CHY zinc finger-like	1	1
PreATP-grasp domain	PurM C-terminal domain-like	1	1
PRTase-like	PRTase-like	1	1
LDL receptor-like module	Lipovitellin-phosvitin complex; beta-sheet shell regions	1	1
MoeA N-terminal region -like	MoeA C-terminal domain-like	1	1
Immunoglobulin	Kringle-like	1	1
Voltage-gated potassium channels	Pentapeptide repeat-like	1	1
BPTI-like	Serine protease inhibitors	1	1
SAP domain	Family A G protein-coupled receptor-like	1	1
Nitrite/Sulfite reductase N-terminal domain-like	Precorrin-8X methylmutase CbiC/CobH	1	1
RING/U-box	Fibrinogen C-terminal domain-like	1	1
ARM repeat	WWE domain	1	1
EF-hand	FnI-like domain	1	1
EAL domain-like	Metallo-dependent hydrolases	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Composite domain of metallo-dependent hydrolases	1	1
Kazal-type serine protease inhibitors	FnI-like domain	1	1
Tricorn protease domain 2	DPP6 N-terminal domain-like	1	1
SMAD/FHA domain	RING/U-box	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1	1
RING/U-box	PDZ domain-like	1	1
Protease propeptides/inhibitors	Protease propeptides/inhibitors	1	1
Trypsin-like serine proteases	DEATH domain	1	1
TPR-like	TSP type-3 repeat	1	1
Aminoacid dehydrogenase-like, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Actin-like ATPase domain	NAD kinase/diacylglycerol kinase-like	1	1
vWA-like	Sensory domain-like	1	1
Chondroitin AC/alginate lyase	Hyaluronate lyase-like, C-terminal domain	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
DNA/RNA polymerases	DHH phosphoesterases	1	1
P-loop containing nucleoside triphosphate hydrolases	AN1-like Zinc finger	1	1
Acyl-CoA binding protein	ClpP/crotonase	1	1
Ubiquitin-like	HAD-like	1	1
Ankyrin repeat	FYVE/PHD zinc finger	1	1
RNI-like	Concanavalin A-like lectins/glucanases	1	1
E2F-DP heterodimerization region	Alkaline phosphatase-like	1	1
Nucleotidylyl transferase	Nucleotidylyl transferase	1	1
Protein kinase-like (PK-like)	BEACH domain	1	1
E set domains	Cupredoxins	1	1
Histone-fold	POZ domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	1	1
Periplasmic binding protein-like II	Protein kinase-like (PK-like)	1	1
Methionine synthase domain	Methionine synthase activation domain-like	1	1
SH3-domain	ARM repeat	1	1
Cytochrome b5-like heme/steroid binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Ankyrin repeat	1	1
PUG domain-like	Cysteine proteinases	1	1
GST C-terminal domain-like	GST C-terminal domain-like	1	1
PABC (PABP) domain	Hect, E3 ligase catalytic domain	1	1
TSP-1 type 1 repeat	PGBD-like	1	1
Ankyrin repeat	EF-hand	1	1
E set domains	Hect, E3 ligase catalytic domain	1	1
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain	WD40 repeat-like	1	1
Homocysteine S-methyltransferase	Methionine synthase domain	1	1
R3H domain	Ankyrin repeat	1	1
SH2 domain	SH2 domain	1	1
tRNA-guanine transglycosylase	tRNA-guanine transglycosylase	1	1
FYVE/PHD zinc finger	EF-hand	1	1
DNase I-like	EGF/Laminin	1	1
Fibrinogen C-terminal domain-like	SNARE-like	1	1
Flavoproteins	Radical SAM enzymes	1	1
Complement control module/SCR domain	TSP-1 type 1 repeat	1	1
Calponin-homology domain, CH-domain	Glucocorticoid receptor-like (DNA-binding domain)	1	1
Tudor/PWWP/MBT	RING/U-box	1	1
V-type ATP synthase subunit C	Phosphoenolpyruvate/pyruvate domain	1	1
EGF/Laminin	beta-beta-alpha zinc fingers	1	1
SAP domain	RNA-binding domain, RBD	1	1
SH3-domain	beta-beta-alpha zinc fingers	1	1
SET domain	beta-lactamase/transpeptidase-like	1	1
vWA-like	Di-copper centre-containing domain	1	1
Class I glutamine amidotransferase-like	Composite domain of metallo-dependent hydrolases	1	1
beta-N-acetylhexosaminidase-like domain	EGF/Laminin	1	1
Ribosomal protein L25-like	C-terminal domain of ProRS	1	1
PH domain-like	RNI-like	1	1
RNA-binding domain, RBD	PAP/OAS1 substrate-binding domain	1	1
THUMP domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Family A G protein-coupled receptor-like	WD40 repeat-like	1	1
Ribonuclease H-like	Zinc finger domain of DNA polymerase-alpha	1	1
SAP domain	Cytochrome b5-like heme/steroid binding domain	1	1
SMAD/FHA domain	Protein kinase-like (PK-like)	1	1
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	1	1
Cytochrome b5-like heme/steroid binding domain	Galactose-binding domain-like	1	1
Ubiquitin-like	NAD kinase/diacylglycerol kinase-like	1	1
Cobalamin (vitamin B12)-dependent enzymes	Cobalamin (vitamin B12)-binding domain	1	1
SEA domain	RING/U-box	1	1
Family A G protein-coupled receptor-like	Spectrin repeat	1	1
Tex N-terminal region-like	SH2 domain	1	1
alpha/beta-Hydrolases	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
Immunoglobulin	Fibrinogen C-terminal domain-like	1	1
Second domain of FERM	SH3-domain	1	1
ISP domain	Ferritin-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Protein kinase-like (PK-like)	1	1
Sema domain	TSP-1 type 1 repeat	1	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	1	1
RING/U-box	R3H domain	1	1
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Methenyltetrahydrofolate cyclohydrolase-like	1	1
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	1	1
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	1	1
Fibronectin type III	Hect, E3 ligase catalytic domain	1	1
RNI-like	Fibronectin type III	1	1
RNA-binding domain, RBD	RNI-like	1	1
Staphylococcal nuclease	Tudor/PWWP/MBT	1	1
Chaperone J-domain	Sec63 N-terminal domain-like	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain III	1	1
P-loop containing nucleoside triphosphate hydrolases	Alkaline phosphatase-like	1	1
Intermediate filament protein, coiled coil region	Intermediate filament protein, coiled coil region	1	1
UBA-like	DNase I-like	1	1
RNI-like	Voltage-gated potassium channels	1	1
Bromodomain	RING/U-box	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
P-loop containing nucleoside triphosphate hydrolases	CYTH-like phosphatases	1	1
WD40 repeat-like	E set domains	1	1
Second domain of FERM	FAT domain of focal adhesion kinase	1	1
P-loop containing nucleoside triphosphate hydrolases	GTPase activation domain, GAP	1	1
SAP domain	RING/U-box	1	1
Second domain of FERM	I/LWEQ domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Bet v1-like	1	1
PA domain	RING/U-box	1	1
BRCA2 helical domain	Nucleic acid-binding proteins	1	1
SWIB/MDM2 domain	eIF1-like	1	1
MAST3 pre-PK domain-like	Protein kinase-like (PK-like)	1	1
OmpA-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
FGAM synthase PurL, linker domain	Class I glutamine amidotransferase-like	1	1
TRAF domain-like	Trimerization domain of TRAF	1	1
Thioredoxin-like	Six-hairpin glycosidases	1	1
Domain of poly(ADP-ribose) polymerase	vWA-like	1	1
MIT domain	Calpain large subunit, middle domain (domain III)	1	1
Surp module (SWAP domain)	Ubiquitin-like	1	1
Ubiquitin-like	Zn-dependent exopeptidases	1	1
Pre-PUA domain	PUA domain-like	1	1
WD40 repeat-like	SAM/Pointed domain	1	1
(Trans)glycosidases	Six-hairpin glycosidases	1	1
EF-hand	Eferin C-derminal domain-like	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain II	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
FYVE/PHD zinc finger	Chromo domain-like	1	1
Galactose-binding domain-like	SAM/Pointed domain	1	1
NagB/RpiA/CoA transferase-like	alpha-helical ferredoxin	1	1
lambda repressor-like DNA-binding domains	TNF-like	1	1
"Winged helix" DNA-binding domain	Transducin (heterotrimeric G protein), gamma chain	1	1
PH domain-like	Glycolipid transfer protein, GLTP	1	1
TSP-1 type 1 repeat	vWA-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Smc hinge domain	1	1
PurS-like	Class I glutamine amidotransferase-like	1	1
Molybdenum cofactor biosynthesis proteins	Adenine nucleotide alpha hydrolases-like	1	1
EGF/Laminin	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Periplasmic binding protein-like I	Voltage-gated potassium channels	1	1
ARM repeat	Second domain of FERM	1	1
P-loop containing nucleoside triphosphate hydrolases	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	1	1
Rap/Ran-GAP	PDZ domain-like	1	1
E set domains	Galactose-binding domain-like	1	1
Ferritin-like	Ferritin-like	1	1
EF-hand	DUSP-like	1	1
PGBD-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Pseudouridine synthase	PUA domain-like	1	1
RING/U-box	Cyclophilin-like	1	1
Glutathione synthetase ATP-binding domain-like	Formyltransferase	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
Nqo1 middle domain-like	Nqo1C-terminal domain-like	1	1
Kazal-type serine protease inhibitors	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	1	1
DNase I-like	C-type lectin-like	1	1
Nucleic acid-binding proteins	SH2 domain	1	1
Anthrax protective antigen	Family A G protein-coupled receptor-like	1	1
Ribonuclease H-like	HRDC-like	1	1
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	1	1
Ricin B-like lectins	Galactose-binding domain-like	1	1
ARM repeat	Fibronectin type III	1	1
Sialidases	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
USP8 N-terminal domain-like	WW domain	1	1
Histone-fold	Macro domain-like	1	1
Transmembrane di-heme cytochromes	Radical SAM enzymes	1	1
Spectrin repeat	RING/U-box	1	1
Cytochrome P450	Cytochrome P450	1	1
EF-hand	NAD kinase/diacylglycerol kinase-like	1	1
Sensory domain-like	PR-1-like	1	1
SRCR-like	LDL receptor-like module	1	1
Caspase-like	Caspase-like	1	1
ISP transmembrane anchor	ISP domain	1	1
BAR/IMD domain-like	Ankyrin repeat	1	1
PH domain-like	RCC1/BLIP-II	1	1
Ribosomal protein S5 domain 2-like	Nucleic acid-binding proteins	1	1
PreATP-grasp domain	Formyltransferase	1	1
PLP-dependent transferases	Adenine nucleotide alpha hydrolases-like	1	1
RuvA domain 2-like	F-box domain	1	1
PH domain-like	Bet v1-like	1	1
Ypt/Rab-GAP domain of gyp1p	EF-hand	1	1
TNF receptor-like	TNF receptor-like	1	1
EF-hand	PX domain	1	1
Class II aaRS ABD-related	C-terminal domain of ProRS	1	1
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	1	1
Hairpin loop containing domain-like	Six-hairpin glycosidases	1	1
FYVE/PHD zinc finger	SMAD/FHA domain	1	1
PLP-dependent transferases	MOSC N-terminal domain-like	1	1
DNA-binding protein LAG-1 (CSL)	E set domains	1	1
SMI1/KNR4-like	ApaG-like	1	1
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Fzo-like conserved region	1	1
ACP-like	Trimeric LpxA-like enzymes	1	1
Immunoglobulin	Hormone receptor domain	1	1
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	1	1
Tudor/PWWP/MBT	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Protein kinase-like (PK-like)	Rhodanese/Cell cycle control phosphatase	1	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	1	1
FF domain	GTPase activation domain, GAP	1	1
F-box domain	ApaG-like	1	1
SH2 domain	Cysteine-rich domain	1	1
Nucleotide-diphospho-sugar transferases	Poly A polymerase C-terminal region-like	1	1
Restriction endonuclease-like	EGF/Laminin	1	1
Spermadhesin, CUB domain	SEA domain	1	1
C-type lectin-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
S-adenosyl-L-methionine-dependent methyltransferases	YebC-like	1	1
Clathrin heavy-chain terminal domain	ARM repeat	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain I	1	1
Nitric oxide (NO) synthase oxygenase domain	Riboflavin synthase domain-like	1	1
BRCT domain	DBL homology domain (DH-domain)	1	1
L domain-like	Protein kinase-like (PK-like)	1	1
Metallo-hydrolase/oxidoreductase	Macro domain-like	1	1
Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	1	1
WD40 repeat-like	MFS general substrate transporter	1	1
RNA-binding domain, RBD	DPP6 N-terminal domain-like	1	1
Galactose mutarotase-like	Hyaluronate lyase-like, C-terminal domain	1	1
F-box domain	Fibronectin type III	1	1
Immunoglobulin	Hairpin loop containing domain-like	1	1
Nucleotidylyl transferase	MOP-like	1	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	1	1
Ankyrin repeat	FabD/lysophospholipase-like	1	1
Outer arm dynein light chain 1	P-loop containing nucleoside triphosphate hydrolases	1	1
alpha-helical ferredoxin	4Fe-4S ferredoxins	1	1
DBL homology domain (DH-domain)	SH2 domain	1	1
PLC-like phosphodiesterases	C-type lectin-like	1	1
ISP domain	Bet v1-like	1	1
Ribosomal protein L25-like	Class II aaRS and biotin synthetases	1	1
DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	1	1
FnI-like domain	Kringle-like	1	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
beta-sandwich domain of Sec23/24	Formin homology 2 domain (FH2 domain)	1	1
Periplasmic binding protein-like II	Periplasmic binding protein-like II	1	1
Retrovirus zinc finger-like domains	PAP/OAS1 substrate-binding domain	1	1
Thioredoxin-like	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
TPR-like	Ankyrin repeat	1	1
PLP-dependent transferases	PLP-dependent transferases	1	1
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	1	1
TPR-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Plexin repeat	GTPase activation domain, GAP	1	1
RNA-binding domain, RBD	F-box domain	1	1
GTPase activation domain, GAP	ARM repeat	1	1
Second domain of FERM	alpha-catenin/vinculin-like	1	1
Cytochrome b5-like heme/steroid binding domain	Tudor/PWWP/MBT	1	1
RCC1/BLIP-II	Cytochrome b5-like heme/steroid binding domain	1	1
p53-like transcription factors	p53 tetramerization domain	1	1
WD40 repeat-like	Cysteine proteinases	1	1
PH domain-like	FAT domain of focal adhesion kinase	1	1
SNF-like	Bet v1-like	1	1
Elongation factor Ts (EF-Ts), dimerisation domain	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
CalX-like	(Phosphotyrosine protein) phosphatases II	1	1
DNA/RNA polymerases	MFS general substrate transporter	1	1
Ribonuclease H-like	EGF/Laminin	1	1
Glutathione synthetase ATP-binding domain-like	PurM C-terminal domain-like	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	LysM domain	1	1
Heat shock protein 70kD (HSP70), C-terminal subdomain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	1	1
Ubiquitin-like	Zn-binding ribosomal proteins	1	1
G protein-binding domain	PH domain-like	1	1
PDZ domain-like	Ras GEF	1	1
I/LWEQ domain	I/LWEQ domain	1	1
FYVE/PHD zinc finger	SAICAR synthase-like	1	1
Cupredoxins	HAMP domain-like	1	1
DEATH domain	WD40 repeat-like	1	1
Tubby C-terminal domain-like	DNA/RNA polymerases	1	1
PDZ domain-like	BAR/IMD domain-like	1	1
The spindle assembly checkpoint protein mad2	FYVE/PHD zinc finger	1	1
RuvA domain 2-like	DNase I-like	1	1
"Winged helix" DNA-binding domain	occludin/ELL-like	1	1
UBC-like	Ribosomal protein S5 domain 2-like	1	1
Ubiquitin-like	Cap-Gly domain	1	1
SH3-domain	RUN domain-like	1	1
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	1	1
E set domains	Terpenoid cyclases/Protein prenyltransferases	1	1
SH2 domain	Ankyrin repeat	1	1
Nucleotide-diphospho-sugar transferases	Nucleotidyltransferase	1	1
Glutathione synthetase ATP-binding domain-like	Citrate synthase	1	1
DNA breaking-rejoining enzymes	Eukaryotic DNA topoisomerase I, dispensable insert domain	1	1
A heparin-binding domain	CAPPD, an extracellular domain of amyloid beta A4 protein	1	1
BRCA2 helical domain	BRCA2 tower domain	1	1
Notch domain	Notch domain	1	1
L domain-like	Hormone receptor domain	1	1
Homeodomain-like	Cupredoxins	1	1
Cobalamin (vitamin B12)-binding domain	Methionine synthase activation domain-like	1	1
PDZ domain-like	Regulator of G-protein signaling, RGS	1	1
EGF/Laminin	DEK C-terminal domain	1	1
PurM C-terminal domain-like	Formyltransferase	1	1
BRCT domain	WGR domain-like	1	1
TPR-like	RNA-binding domain, RBD	1	1
WW domain	FF domain	1	1
PH domain-like	Ypt/Rab-GAP domain of gyp1p	1	1
Fibrinogen C-terminal domain-like	Voltage-gated potassium channels	1	1
L9 N-domain-like	Ribosomal protein L9 C-domain	1	1
beta-beta-alpha zinc fingers	WW domain	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Aspartate/ornithine carbamoyltransferase	1	1
Class I glutamine amidotransferase-like	Ribulose-phoshate binding barrel	1	1
P-loop containing nucleoside triphosphate hydrolases	Fibrinogen C-terminal domain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	MetI-like	1	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	1	1
PUA domain-like	Ribosomal protein S5 domain 2-like	1	1
GST C-terminal domain-like	Nucleotidylyl transferase	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Ribokinase-like	1	1
Fibronectin type III	Thioredoxin-like	1	1
GAF domain-like	PYP-like sensor domain (PAS domain)	1	1
SH3-domain	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Isocitrate/Isopropylmalate dehydrogenase-like	Porins	1	1
Fibronectin type III	SAM/Pointed domain	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	YWTD domain	1	1
Ubiquitin-like	XPC-binding domain	1	1
SH3-domain	WW domain	1	1
Concanavalin A-like lectins/glucanases	Carbohydrate-binding domain	1	1
SIS domain	SIS domain	1	1
POZ domain	WD40 repeat-like	1	1
Cysteine proteinases	Transglutaminase, two C-terminal domains	1	1
GYF domain	ARM repeat	1	1
RING/U-box	Trimerization domain of TRAF	1	1
P-loop containing nucleoside triphosphate hydrolases	PEBP-like	1	1
TPR-like	MgtE N-terminal domain-like	1	1
Homeodomain-like	JAB1/MPN domain	1	1
P-loop containing nucleoside triphosphate hydrolases	WW domain	1	1
L domain-like	NTF2-like	1	1
ARM repeat	Galactose-binding domain-like	1	1
Nucleotide-binding domain	4Fe-4S ferredoxins	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	1	1
TRAF domain-like	NRDP1 C-terminal domain-like	1	1
Six-hairpin glycosidases	P-loop containing nucleoside triphosphate hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	ArfGap/RecO-like zinc finger	1	1
PH domain-like	Cullin repeat-like	1	1
Nucleotidylyl transferase	Class II aaRS and biotin synthetases	1	1
Ran binding protein zinc finger-like	RING/U-box	1	1
Tubby C-terminal domain-like	Ribonuclease H-like	1	1
Immunoglobulin	LDL receptor-like module	1	1
HD-domain/PDEase-like	HD-domain/PDEase-like	1	1
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	1	1
G protein-binding domain	Cysteine-rich domain	1	1
Retrovirus zinc finger-like domains	Nucleotidyltransferase	1	1
RNA-binding domain, RBD	Nucleotidyltransferase	1	1
Ferredoxin reductase-like, C-terminal NADP-linked domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Calcium-dependent phosphotriesterase	EGF/Laminin	1	1
ENTH/VHS domain	Clathrin adaptor appendage domain	1	1
TPR-like	Chaperone J-domain	1	1
L9 N-domain-like	Ribonuclease H-like	1	1
Adhesin YadA, collagen-binding domain	Pseudouridine synthase	1	1
Indigoidine synthase A-like	Ribokinase-like	1	1
HAD-like	Acyl-CoA dehydrogenase NM domain-like	1	1
Hairpin loop containing domain-like	DNA/RNA polymerases	1	1
ARM repeat	PX domain	1	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	1	1
Calcium-dependent phosphotriesterase	YWTD domain	1	1
Ubiquitin-like	(Phosphotyrosine protein) phosphatases II	1	1
Nucleic acid-binding proteins	BRCT domain	1	1
Fibronectin type III	MFS general substrate transporter	1	1
Surp module (SWAP domain)	ENTH/VHS domain	1	1
Kelch motif	Growth factor receptor domain	1	1
RNA-binding domain, RBD	Surp module (SWAP domain)	1	1
Ypt/Rab-GAP domain of gyp1p	Concanavalin A-like lectins/glucanases	1	1
UBA-like	WWE domain	1	1
Fibrinogen C-terminal domain-like	TSP-1 type 1 repeat	1	1
SH2 domain	PLC-like phosphodiesterases	1	1
BEACH domain	FYVE/PHD zinc finger	1	1
Protein kinase-like (PK-like)	HCP-like	1	1
Calpain large subunit, middle domain (domain III)	Calpain large subunit, middle domain (domain III)	1	1
Ribosomal protein S5 domain 2-like	Periplasmic binding protein-like II	1	1
Nucleic acid-binding proteins	BRCA2 tower domain	1	1
SRCR-like	EGF/Laminin	1	1
CSL zinc finger	Chaperone J-domain	1	1
CheW-like	CheY-like	1	1
Rhomboid-like	UBA-like	1	1
PH domain-like	NAD kinase/diacylglycerol kinase-like	1	1
TPR-like	MgtE membrane domain-like	1	1
Chaperone J-domain	ARM repeat	1	1
Ankyrin repeat	Second domain of FERM	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
Tetrahydrobiopterin biosynthesis enzymes-like	Tetrahydrobiopterin biosynthesis enzymes-like	1	1
PheT/TilS domain	Class II aaRS and biotin synthetases	1	1
Galactose-binding domain-like	Hyaluronate lyase-like, C-terminal domain	1	1
BRK domain-like	Bromodomain	1	1
vWA-like	Cysteine proteinases	1	1
PYP-like sensor domain (PAS domain)	Nucleotide cyclase	1	1
Fibronectin type III	CalX-like	1	1
Cupredoxins	Nucleotide cyclase	1	1
RING/U-box	Tricorn protease domain 2	1	1
ENT-like	Bromodomain	1	1
HIT/MYND zinc finger-like	HIT/MYND zinc finger-like	1	1
dsRNA-binding domain-like	Nudix	1	1
TPR-like	Fic-like	1	1
Growth factor receptor domain	Immunoglobulin	1	1
SAM/Pointed domain	ArfGap/RecO-like zinc finger	1	1
ACP-like	ALDH-like	1	1
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	1	1
SH3-domain	PLC-like phosphodiesterases	1	1
FabD/lysophospholipase-like	EF-hand	1	1
Ankyrin repeat	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Cobalamin (vitamin B12)-dependent enzymes	1	1
P-loop containing nucleoside triphosphate hydrolases	Quinoprotein alcohol dehydrogenase-like	1	1
alpha/beta-Hydrolases	Carbamate kinase-like	1	1
PurM C-terminal domain-like	Class I glutamine amidotransferase-like	1	1
RNA-binding domain, RBD	GYF domain	1	1
RING/U-box	ARM repeat	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
Fibronectin type III	Periplasmic binding protein-like II	1	1
F-box domain	Voltage-gated potassium channels	1	1
FF domain	FF domain	1	1
Protein kinase-like (PK-like)	(Phosphotyrosine protein) phosphatases II	1	1
Homocysteine S-methyltransferase	Dihydropteroate synthetase-like	1	1
RING/U-box	Hairpin loop containing domain-like	1	1
Cytochrome b5-like heme/steroid binding domain	UBA-like	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	PKD domain	1	1
Kelch motif	BAR/IMD domain-like	1	1
AbfB domain	AbfB domain	1	1
Spermadhesin, CUB domain	Trypsin-like serine proteases	1	1
Activator of Hsp90 ATPase, Aha1	Bet v1-like	1	1
Sema domain	E set domains	1	1
NTF2-like	UBA-like	1	1
Lipoxigenase	Lipoxigenase	1	1
CAD & PB1 domains	PDZ domain-like	1	1
WW domain	PIN domain-like	1	1
Cytochrome b5-like heme/steroid binding domain	Mib/herc2 domain-like	1	1
RING/U-box	DUSP-like	1	1
Kelch motif	SH3-domain	1	1
MgtE N-terminal domain-like	MgtE membrane domain-like	1	1
vWA-like	Cysteine-rich domain	1	1
HAD-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Quinoprotein alcohol dehydrogenase-like	EF-hand	1	1
TSP-1 type 1 repeat	Anthrax protective antigen	1	1
PGBD-like	L,D-transpeptidase catalytic domain-like	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	Fibronectin type III	1	1
MFS general substrate transporter	Periplasmic binding protein-like II	1	1
PDZ domain-like	PX domain	1	1
(Phosphotyrosine protein) phosphatases II	Nucleic acid-binding proteins	1	1
Thioredoxin-like	Family A G protein-coupled receptor-like	1	1
DEATH domain	SH2 domain	1	1
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Oligoxyloglucan reducing end-specific cellobiohydrolase	1	1
Growth factor receptor domain	TNF receptor-like	1	1
His-Me finger endonucleases	Ribonuclease H-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Chaperone J-domain	1	1
Spectrin repeat	WW domain	1	1
EF-hand	Dimeric alpha+beta barrel	1	1
FYVE/PHD zinc finger	RNI-like	1	1
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
CSL zinc finger	CSL zinc finger	1	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	1	1
WW domain	NAD(P)-binding Rossmann-fold domains	1	1
C-type lectin-like	Putative cyclase	1	1
dsRNA-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Retrovirus zinc finger-like domains	Acid proteases	1	1
L27 domain	L27 domain	1	1
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	1	1
FAD/NAD(P)-binding domain	EF-hand	1	1
TPR-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
F-box domain	SMI1/KNR4-like	1	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
EGF/Laminin	V-type ATP synthase subunit C	1	1
BRCT domain	post-AAA+ oligomerization domain-like	1	1
beta-beta-alpha zinc fingers	CCCH zinc finger	1	1
UBA-like	XPC-binding domain	1	1
IP3 receptor type 1 binding core, domain 2	ARM repeat	1	1
WD40 repeat-like	Ribonuclease H-like	1	1
Thioredoxin-like	FAD-dependent thiol oxidase	1	1
Calponin-homology domain, CH-domain	Concanavalin A-like lectins/glucanases	1	1
FnI-like domain	Serine protease inhibitors	1	1
FGAM synthase PurL, linker domain	PurM N-terminal domain-like	1	1
EGF/Laminin	Notch domain	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
Alpha subunit of glutamate synthase, C-terminal domain	alpha-helical ferredoxin	1	1
alpha/beta knot	Nucleic acid-binding proteins	1	1
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	1	1
Protein kinase-like (PK-like)	Ypt/Rab-GAP domain of gyp1p	1	1
RCC1/BLIP-II	UBA-like	1	1
C-type lectin-like	vWA-like	1	1
RCC1/BLIP-II	Mib/herc2 domain-like	1	1
Ubiquitin-like	PX domain	1	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	1	1
Homeodomain-like	SIS domain	1	1
AF0104/ALDC/Ptd012-like	AF0104/ALDC/Ptd012-like	1	1
MIT domain	Cysteine proteinases	1	1
PH domain-like	C-terminal domain of PLC-beta	1	1
EF-hand	GAS2 domain-like	1	1
EPT/RTPC-like	EPT/RTPC-like	1	1
Ankyrin repeat	RCC1/BLIP-II	1	1
Hairpin loop containing domain-like	Kringle-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Ubiquitin-like	1	1
F-box domain	P-loop containing nucleoside triphosphate hydrolases	1	1
NAD(P)-binding Rossmann-fold domains	Citrate synthase	1	1
FMN-linked oxidoreductases	dsRNA-binding domain-like	1	1
HAD-like	Acyl-CoA dehydrogenase C-terminal domain-like	1	1
CCHHC domain	Acyl-CoA N-acyltransferases (Nat)	1	1
Carboxypeptidase regulatory domain-like	OmpA-like	1	1
(Trans)glycosidases	Acyl-CoA N-acyltransferases (Nat)	1	1
Immunoglobulin	Invertebrate chitin-binding proteins	1	1
NAD(P)-binding Rossmann-fold domains	Thioesterase/thiol ester dehydrase-isomerase	1	1
Rap/Ran-GAP	Rap/Ran-GAP	1	1
mRNA decapping enzyme DcpS N-terminal domain	HIT-like	1	1
USP8 N-terminal domain-like	Rhodanese/Cell cycle control phosphatase	1	1
Outer arm dynein light chain 1	WD40 repeat-like	1	1
RUN domain-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
RuvA domain 2-like	Pentapeptide repeat-like	1	1
Ribonuclease H-like	SH2 domain	1	1
POZ domain	Galactose-binding domain-like	1	1
CRAL/TRIO N-terminal domain	(Phosphotyrosine protein) phosphatases II	1	1
Saposin	SGNH hydrolase	1	1
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	1	1
E set domains	Thioredoxin-like	1	1
L30e-like	alpha/beta knot	1	1
Actin-like ATPase domain	CheY-like	1	1
Metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	1	1
WD40 repeat-like	Tricorn protease domain 2	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	CalX-like	1	1
POZ domain	Pentapeptide repeat-like	1	1
TPR-like	Immunoglobulin	1	1
Macro domain-like	CRAL/TRIO domain	1	1
PreATP-grasp domain	PurM N-terminal domain-like	1	1
Actin-like ATPase domain	CheW-like	1	1
Tetrahydrobiopterin biosynthesis enzymes-like	6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	1	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Metallo-dependent hydrolases	1	1
Class I glutamine amidotransferase-like	Metallo-dependent hydrolases	1	1
Intermediate filament protein, coiled coil region	Lamin A/C globular tail domain	1	1
Phospholipase A2, PLA2	Phospholipase A2, PLA2	1	1
MgtE N-terminal domain-like	CBS-domain pair	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	ARM repeat	1	1
PRP4-like	WD40 repeat-like	1	1
Immunoglobulin	(Phosphotyrosine protein) phosphatases II	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	1	1
Calponin-homology domain, CH-domain	SH3-domain	1	1
Dihydropteroate synthetase-like	Methionine synthase domain	1	1
TSP-1 type 1 repeat	C-type lectin-like	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Fibronectin type III	1	1
PR-1-like	SOCS box-like	1	1
Concanavalin A-like lectins/glucanases	ADP-ribosylation	1	1
UBA-like	Ricin B-like lectins	1	1
Second domain of FERM	(Phosphotyrosine protein) phosphatases II	1	1
PH domain-like	Regulator of G-protein signaling, RGS	1	1
Glutathione synthetase ATP-binding domain-like	NAD(P)-binding Rossmann-fold domains	1	1
CRAL/TRIO N-terminal domain	PapD-like	1	1
BSD domain-like	BSD domain-like	1	1
CheY-like	Methylesterase CheB, C-terminal domain	1	1
S13-like H2TH domain	Glucocorticoid receptor-like (DNA-binding domain)	1	1
F-box domain	HCP-like	1	1
beta-beta-alpha zinc fingers	Nucleotidyltransferase	1	1
FGAM synthase PurL, linker domain	PurM C-terminal domain-like	1	1
Ankyrin repeat	Cap-Gly domain	1	1
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	1	1
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	1	1
Protein kinase-like (PK-like)	PDZ domain-like	1	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	VPS9 domain	1	1
CBS-domain pair	CBS-domain pair	1	1
Immunoglobulin	MFS general substrate transporter	1	1
Epsilon subunit of F1F0-ATP synthase N-terminal domain	Epsilon subunit of F1F0-ATP synthase C-terminal domain	1	1
Composite domain of metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	1	1
FAD-linked reductases, C-terminal domain	EF-hand	1	1
Concanavalin A-like lectins/glucanases	Ricin B-like lectins	1	1
EPT/RTPC-like	RNA 3'-terminal phosphate cyclase, RPTC, insert domain	1	1
L domain-like	EGF/Laminin	1	1
SEA domain	TPR-like	1	1
CAD & PB1 domains	His-Me finger endonucleases	1	1
Galactose-binding domain-like	Bet v1-like	1	1
ARM repeat	POZ domain	1	1
TAZ domain	Bromodomain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Nucleic acid-binding proteins	1	1
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	1	1
Histone-fold	ARM repeat	1	1
Ankyrin repeat	WD40 repeat-like	1	1
RNA-binding domain, RBD	PABC (PABP) domain	1	1
p53-like transcription factors	SH2 domain	1	1
SMAD/FHA domain	dsRNA-binding domain-like	1	1
Homeodomain-like	EAL domain-like	1	1
UBC-like	Protein kinase-like (PK-like)	1	1
"Winged helix" DNA-binding domain	Ras GEF	1	1
EF-hand	C-terminal domain of PLC-beta	1	1
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	1	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	1	1
TAFH domain-like	Histone-fold	1	1
TolB, C-terminal domain	TPR-like	1	1
Pentein	Translation proteins	1	1
Concanavalin A-like lectins/glucanases	DNase I-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
Radical SAM enzymes	Molybdenum cofactor biosynthesis protein C, MoaC	1	1
HAD-like	Protein kinase-like (PK-like)	1	1
Thioredoxin-like	AraD/HMP-PK domain-like	1	1
F-box domain	DBL homology domain (DH-domain)	1	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	1	1
BRCT domain	PH domain-like	1	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Chaperone J-domain	1	1
G protein-binding domain	FYVE/PHD zinc finger	1	1
NAD(P)-binding Rossmann-fold domains	NagB/RpiA/CoA transferase-like	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
Ubiquitin-like	BAG domain	1	1
Chromo domain-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
F-box domain	Cyclin-like	1	1
Trefoil	LDL receptor-like module	1	1
PH domain-like	I/LWEQ domain	1	1
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	1	1
Tudor/PWWP/MBT	Fibrinogen C-terminal domain-like	1	1
FYVE/PHD zinc finger	SAP domain	1	1
DEK C-terminal domain	(Phosphotyrosine protein) phosphatases II	1	1
P-loop containing nucleoside triphosphate hydrolases	S-adenosyl-L-methionine-dependent methyltransferases	1	1
RING/U-box	Galactose-binding domain-like	1	1
Tudor/PWWP/MBT	Galactose-binding domain-like	1	1
L domain-like	SAM/Pointed domain	1	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	1	1
Nucleotide-diphospho-sugar transferases	Ribosomal protein S5 domain 2-like	1	1
EF-hand	GAF domain-like	1	1
UBA-like	NSFL1 (p97 ATPase) cofactor p47, SEP domain	1	1
Calponin-homology domain, CH-domain	DNA/RNA polymerases	1	1
Kazal-type serine protease inhibitors	Concanavalin A-like lectins/glucanases	1	1
DEATH domain	NHL repeat	1	1
Pectin lyase-like	Tudor/PWWP/MBT	1	1
N-terminal domain of MutM-like DNA repair proteins	S13-like H2TH domain	1	1
Ubiquitin-like	SH3-domain	1	1
post-AAA+ oligomerization domain-like	post-AAA+ oligomerization domain-like	1	1
Nucleotide-diphospho-sugar transferases	GHMP Kinase, C-terminal domain	1	1
Nitrite/Sulfite reductase N-terminal domain-like	CbiG N-terminal domain-like	1	1
PAH2 domain	PAH2 domain	1	1
RUN domain-like	RUN domain-like	1	1
DEK C-terminal domain	SWIB/MDM2 domain	1	1
Ricin B-like lectins	Alkaline phosphatase-like	1	1
WW domain	RING/U-box	1	1
RING/U-box	Hect, E3 ligase catalytic domain	1	1
TSP-1 type 1 repeat	Cadherin-like	1	1
C-type lectin-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Clavaminate synthase-like	Tetraspanin	1	1
Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	1	1
HR1 repeat	HR1 repeat	1	1
L domain-like	ADP-ribosylglycohydrolase	1	1
P-loop containing nucleoside triphosphate hydrolases	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	1	1
EGF/Laminin	Ankyrin repeat	1	1
Alpha subunit of glutamate synthase, C-terminal domain	Nucleotide-binding domain	1	1
SRCR-like	Spermadhesin, CUB domain	1	1
Actin depolymerizing proteins	SH3-domain	1	1
Bcl-2 inhibitors of programmed cell death	Invertebrate chitin-binding proteins	1	1
Bet v1-like	HAD-like	1	1
RNI-like	Fibrinogen C-terminal domain-like	1	1
PHM/PNGase F	NHL repeat	1	1
EGF/Laminin	SWIB/MDM2 domain	1	1
PH domain-like	Ran binding protein zinc finger-like	1	1
E set domains	cAMP-binding domain-like	1	1
Doublecortin (DC)	Protein kinase-like (PK-like)	1	1
WD40 repeat-like	Chromo domain-like	1	1
(Trans)glycosidases	Restriction endonuclease-like	1	1
STAT	p53-like transcription factors	1	1
PH domain-like	Phospholipase D/nuclease	1	1
Kix domain of CBP (creb binding protein)	Bromodomain	1	1
Glycerol-3-phosphate (1)-acyltransferase	EF-hand	1	1
RNA-binding domain, RBD	SPOC domain-like	1	1
SEA domain	Voltage-gated potassium channels	1	1
Cysteine proteinases	Globin-like	1	1
CRAL/TRIO domain	GTPase activation domain, GAP	1	1
vWA-like	Hairpin loop containing domain-like	1	1
Formyltransferase	ACP-like	1	1
Immunoglobulin	Frizzled cysteine-rich domain	1	1
PUA domain-like	Nucleotidylyl transferase	1	1
Ribosomal protein L25-like	Class II aaRS ABD-related	1	1
Galactose-binding domain-like	Voltage-gated potassium channels	1	1
Tubby C-terminal domain-like	His-Me finger endonucleases	1	1
WD40 repeat-like	Bromodomain	1	1
PDZ domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
FMT C-terminal domain-like	ACP-like	1	1
HlyD-like secretion proteins	Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains	1	1
Glycerol-3-phosphate (1)-acyltransferase	Cysteine proteinases	1	1
Clavaminate synthase-like	RNI-like	1	1
DNA/RNA polymerases	Zinc finger domain of DNA polymerase-alpha	1	1
"Winged helix" DNA-binding domain	GroEL apical domain-like	1	1
G protein-binding domain	G protein-binding domain	1	1
PUA domain-like	SWIB/MDM2 domain	1	1
C-terminal, gelsolin-like domain of Sec23/24	Actin depolymerizing proteins	1	1
vWA-like	SPOC domain-like	1	1
Urease, beta-subunit	Metallo-dependent hydrolases	1	1
Elafin-like	Immunoglobulin	1	1
Subtilisin-like	Subtilisin-like	1	1
N-terminal domain of adenylylcyclase associated protein, CAP	C-terminal domain of adenylylcyclase associated protein	1	1
TIMP-like	Concanavalin A-like lectins/glucanases	1	1
Carboxypeptidase regulatory domain-like	Carboxypeptidase regulatory domain-like	1	1
F-box domain	PH domain-like	1	1
Urease, beta-subunit	Composite domain of metallo-dependent hydrolases	1	1
WD40 repeat-like	SNARE fusion complex	1	1
SEA domain	Protein kinase-like (PK-like)	1	1
Ribosomal protein S5 domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
PUG domain-like	Ubiquitin-like	1	1
Fibronectin type III	Family A G protein-coupled receptor-like	1	1
Cysteine proteinases	Galactose-binding domain-like	1	1
L domain-like	WD40 repeat-like	1	1
EGF/Laminin	Tropomyosin	1	1
GAF domain-like	Phosphoglucomutase, first 3 domains	1	1
Concanavalin A-like lectins/glucanases	Fibrinogen C-terminal domain-like	1	1
Ubiquitin-like	I/LWEQ domain	1	1
RUN domain-like	PDZ domain-like	1	1
TSP-1 type 1 repeat	PR-1-like	1	1
RNase III domain-like	RNase III domain-like	1	1
vWA-like	Trypsin-like serine proteases	1	1
"Winged helix" DNA-binding domain	SAICAR synthase-like	1	1
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	NagB/RpiA/CoA transferase-like	1	1
UBA-like	Tudor/PWWP/MBT	1	1
Second domain of FERM	Ras GEF	1	1
Cullin repeat-like	Cullin repeat-like	1	1
Ubiquitin-like	FAD-binding/transporter-associated domain-like	1	1
HIT-like	HIT-like	1	1
Tudor/PWWP/MBT	EGF/Laminin	1	1
Ricin B-like lectins	Immunoglobulin	1	1
TRAF domain-like	TPR-like	1	1
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	1	1
PDZ domain-like	ClpP/crotonase	1	1
BRCT domain	Lesion bypass DNA polymerase (Y-family), little finger domain	1	1
PYP-like sensor domain (PAS domain)	CheY-like	1	1
BRCT domain	DNA/RNA polymerases	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	1	1
EF-hand	Tropomyosin	1	1
PurS-like	FGAM synthase PurL, linker domain	1	1
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	1	1
C-type lectin-like	ARM repeat	1	1
Nitrite and sulphite reductase 4Fe-4S domain-like	CbiG N-terminal domain-like	1	1
Retrovirus zinc finger-like domains	DNase I-like	1	1
Ubiquitin-like	TPR-like	1	1
Ankyrin repeat	Hect, E3 ligase catalytic domain	1	1
PHM/PNGase F	BPTI-like	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	1	1
cAMP-binding domain-like	PDZ domain-like	1	1
Ubiquitin-like	FYVE/PHD zinc finger	1	1
Cupredoxins	EAL domain-like	1	1
Concanavalin A-like lectins/glucanases	WD40 repeat-like	1	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	1	1
Protein kinase-like (PK-like)	Toll/Interleukin receptor TIR domain	1	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	1	1
PurS-like	PurM N-terminal domain-like	1	1
Methionine synthase domain	Cobalamin (vitamin B12)-binding domain	1	1
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	1	1
Clc chloride channel	Clc chloride channel	1	1
Ricin B-like lectins	Spermadhesin, CUB domain	1	1
ISP domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
HMA, heavy metal-associated domain	Cu,Zn superoxide dismutase-like	1	1
FAD/NAD(P)-binding domain	Calponin-homology domain, CH-domain	1	1
P-loop containing nucleoside triphosphate hydrolases	vWA-like	1	1
NAD kinase/diacylglycerol kinase-like	CheW-like	1	1
Cytochrome c oxidase subunit I-like	Cytochrome c	1	1
ARM repeat	Zn-dependent exopeptidases	1	1
CCHHC domain	CCHHC domain	1	1
Porins	Homeodomain-like	1	1
A heparin-binding domain	Amyloid beta a4 protein copper binding domain (domain 2)	1	1
Tricorn protease domain 2	ARM repeat	1	1
IP3 receptor type 1 binding core, domain 2	IP3 receptor type 1 binding core, domain 2	1	1
L domain-like	RING/U-box	1	1
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	1	1
B-box zinc-binding domain	TRAF domain-like	1	1
EGF/Laminin	Kringle-like	1	1
TSP-1 type 1 repeat	Periplasmic binding protein-like II	1	1
Pentein	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	1	1
Eukaryotic type KH-domain (KH-domain type I)	Pentein	1	1
Fibronectin type III	Anthrax protective antigen	1	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
MurCD N-terminal domain	MurD-like peptide ligases, peptide-binding domain	1	1
RING/U-box	SH3-domain	1	1
DBL homology domain (DH-domain)	Ras GEF	1	1
SRCR-like	Immunoglobulin	1	1
Cysteine proteinases	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
SH2 domain	Ras GEF	1	1
Amidase signature (AS) enzymes	Cytokine	1	1
Plexin repeat	TSP-1 type 1 repeat	1	1
Rudiment single hybrid motif	PurM N-terminal domain-like	1	1
Nucleotidylyl transferase	Class II aaRS ABD-related	1	1
Cytochrome b5-like heme/steroid binding domain	RING/U-box	1	1
BPTI-like	Elafin-like	1	1
Family A G protein-coupled receptor-like	beta-lactamase/transpeptidase-like	1	1
NAD(P)-binding Rossmann-fold domains	RING/U-box	1	1
Growth factor receptor domain	TSP type-3 repeat	1	1
Chaperone J-domain	EPT/RTPC-like	1	1
EGF/Laminin	Phosphoenolpyruvate/pyruvate domain	1	1
"Winged helix" DNA-binding domain	TSP-1 type 1 repeat	1	1
Ankyrin repeat	SOCS box-like	1	1
SH3-domain	DEATH domain	1	1
Plexin repeat	E set domains	1	1
Urease, gamma-subunit	Composite domain of metallo-dependent hydrolases	1	1
Bromodomain	Tudor/PWWP/MBT	1	1
Family A G protein-coupled receptor-like	POZ domain	1	1
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
Mib/herc2 domain-like	Tudor/PWWP/MBT	1	1
SRCR-like	Trypsin-like serine proteases	1	1
Lipoxigenase	beta-beta-alpha zinc fingers	1	1
Staphylococcal nuclease	Staphylococcal nuclease	1	1
Acetyl-CoA synthetase-like	(Trans)glycosidases	1	1
Voltage-gated potassium channels	NAD(P)-binding Rossmann-fold domains	1	1
Ankyrin repeat	FAD-binding/transporter-associated domain-like	1	1
XRCC4, N-terminal domain	XRCC4, C-terminal oligomerization domain	1	1
Nitric oxide (NO) synthase oxygenase domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Stathmin	Stathmin	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	1	1
E set domains	AMPKBI-like	1	1
ARM repeat	beta-sandwich domain of Sec23/24	1	1
Fibronectin type III	Ankyrin repeat	1	1
Cytochrome c	4Fe-4S ferredoxins	1	1
Histone-fold	Ankyrin repeat	1	1
Formate dehydrogenase/DMSO reductase, domains 1-3	ISP domain	1	1
Chaperone J-domain	Nucleotidyltransferase substrate binding subunit/domain	1	1
ARM repeat	FYVE/PHD zinc finger	1	1
Adhesin YadA, collagen-binding domain	Tropomyosin	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Nucleotide-binding domain	1	1
Class I glutamine amidotransferase-like	Aspartate/ornithine carbamoyltransferase	1	1
I/LWEQ domain	alpha-catenin/vinculin-like	1	1
XRCC4, C-terminal oligomerization domain	Immunoglobulin	1	1
CAD & PB1 domains	Six-hairpin glycosidases	1	1
PreATP-grasp domain	Aspartate/ornithine carbamoyltransferase	1	1
Complement control module/SCR domain	C-type lectin-like	1	1
Plexin repeat	Plexin repeat	1	1
Concanavalin A-like lectins/glucanases	PH domain-like	1	1
Kelch motif	Fibronectin type III	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	1	1
FMN-linked oxidoreductases	4Fe-4S ferredoxins	1	1
Trefoil	EGF/Laminin	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	alpha-helical ferredoxin	1	1
Second domain of FERM	DBL homology domain (DH-domain)	1	1
vWA-like	FYVE/PHD zinc finger	1	1
Cobalamin (vitamin B12)-dependent enzymes	Cobalamin (vitamin B12)-dependent enzymes	1	1
Immunoglobulin	Thyroglobulin type-1 domain	1	1
GTPase activation domain, GAP	Bet v1-like	1	1
HR1 repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
SMAD/FHA domain	BRCT domain	1	1
Spermadhesin, CUB domain	Cadherin-like	1	1
Calcyclin-binding protein-like	HSP20-like chaperones	1	1
Thioesterase/thiol ester dehydrase-isomerase	SCP-like	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
SAP domain	DNase I-like	1	1
Concanavalin A-like lectins/glucanases	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
RuvA domain 2-like	SH2 domain	1	1
Calpain large subunit, middle domain (domain III)	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Fibronectin type III	Complement control module/SCR domain	1	1
DNA/RNA polymerases	DNA breaking-rejoining enzymes	1	1
RNA-binding domain, RBD	TSP-1 type 1 repeat	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Galactose oxidase, central domain	1	1
TAZ domain	RING/U-box	1	1
PLP-dependent transferases	Rudiment single hybrid motif	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	C-terminal domain of PLC-beta	1	1
Nucleotide cyclase	Composite domain of metallo-dependent hydrolases	1	1
GST C-terminal domain-like	eEF1-gamma domain	1	1
TPR-like	Tropomyosin	1	1
HAMP domain-like	EAL domain-like	1	1
YWTD domain	Fibronectin type III	1	1
Adenine nucleotide alpha hydrolases-like	Translation proteins	1	1
P-loop containing nucleoside triphosphate hydrolases	Macro domain-like	1	1
DUSP-like	Ubiquitin-like	1	1
Trefoil	Concanavalin A-like lectins/glucanases	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	S15/NS1 RNA-binding domain	1	1
Anthrax protective antigen	Anthrax protective antigen	1	1
RCC1/BLIP-II	FYVE/PHD zinc finger	1	1
WD40 repeat-like	Putative isomerase YbhE	1	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ATP-dependent DNA ligase DNA-binding domain	1	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	1	1
Transducin (heterotrimeric G protein), gamma chain	Regulator of G-protein signaling, RGS	1	1
beta-beta-alpha zinc fingers	Leucine zipper domain	1	1
ARID-like	FYVE/PHD zinc finger	1	1
Cupredoxins	Pectin lyase-like	1	1
Porins	CarD-like	1	1
ARM repeat	BEACH domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	1	1
TNF-like	TNF-like	1	1
Methylglyoxal synthase-like	Aspartate/ornithine carbamoyltransferase	1	1
S15/NS1 RNA-binding domain	C-terminal domain of ProRS	1	1
DNase I-like	GTPase activation domain, GAP	1	1
Mib/herc2 domain-like	Mib/herc2 domain-like	1	1
Formin homology 2 domain (FH2 domain)	Formin homology 2 domain (FH2 domain)	1	1
ARM repeat	EF-hand	1	1
Galactose-binding domain-like	Kelch motif	1	1
Ribosomal protein L25-like	S15/NS1 RNA-binding domain	1	1
vWA-like	PR-1-like	1	1
DUSP-like	DUSP-like	1	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
ISP domain	FAD/NAD(P)-binding domain	1	1
PurM N-terminal domain-like	Formyltransferase	1	1
L domain-like	Actin depolymerizing proteins	1	1
Hypothetical protein SAV1430	Fe-S cluster assembly (FSCA) domain-like	1	1
Rhodanese/Cell cycle control phosphatase	WW domain	1	1
Ubiquitin-like	Acid proteases	1	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	1	1
ARM repeat	CalX-like	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Hect, E3 ligase catalytic domain	1	1
UBA-like	RNI-like	1	1
Calponin-homology domain, CH-domain	Thioredoxin-like	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
Surp module (SWAP domain)	Surp module (SWAP domain)	1	1
Apolipoprotein A-I	E set domains	1	1
Tudor/PWWP/MBT	Hect, E3 ligase catalytic domain	1	1
MFS general substrate transporter	PH domain-like	1	1
SAICAR synthase-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
F-box domain	Fibrinogen C-terminal domain-like	1	1
NAD(P)-binding Rossmann-fold domains	ACT-like	1	1
Concanavalin A-like lectins/glucanases	L domain-like	1	1
EF-hand	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
Notch domain	Ankyrin repeat	1	1
Kazal-type serine protease inhibitors	Thyroglobulin type-1 domain	1	1
E set domains	EGF/Laminin	1	1
NTF2-like	Fibrinogen C-terminal domain-like	1	1
DNA breaking-rejoining enzymes	Nucleic acid-binding proteins	1	1
UBC-like	Class II aaRS and biotin synthetases	1	1
TPR-like	CBS-domain pair	1	1
EAL domain-like	HD-domain/PDEase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	SH2 domain	1	1
Concanavalin A-like lectins/glucanases	BEACH domain	1	1
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	1	1
Glycosyl hydrolase domain	Glycosyl hydrolase domain	1	1
PX domain	GTPase activation domain, GAP	1	1
"Winged helix" DNA-binding domain	Dimeric alpha+beta barrel	1	1