Domain combination pairs in Nematostella vectensis 1.0

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

2334 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
EGF/Laminin	EGF/Laminin	220	100
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	190	48
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	136	53
Immunoglobulin	Immunoglobulin	120	61
Galactose-binding domain-like	Galactose-binding domain-like	98	22
Nicotinic receptor ligand binding domain-like	Neurotransmitter-gated ion-channel transmembrane pore	91	3
Growth factor receptor domain	EGF/Laminin	89	66
TSP-1 type 1 repeat	TSP-1 type 1 repeat	86	25
TPR-like	TPR-like	83	28
Growth factor receptor domain	Growth factor receptor domain	64	47
RING/U-box	B-box zinc-binding domain	61	15
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	49	9
Cadherin-like	Cadherin-like	49	30
Voltage-gated potassium channels	Voltage-gated potassium channels	44	11
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	43	17
RNA-binding domain, RBD	RNA-binding domain, RBD	43	20
POZ domain	Voltage-gated potassium channels	43	5
Actin-like ATPase domain	Actin-like ATPase domain	41	11
ARM repeat	ARM repeat	40	24
POZ domain	Kelch motif	40	8
Spermadhesin, CUB domain	Spermadhesin, CUB domain	39	20
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	34	25
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	32	16
Immunoglobulin	Fibronectin type III	32	26
EF-hand	EF-hand	31	17
Fibronectin type III	Fibronectin type III	31	27
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	30	3
LDL receptor-like module	LDL receptor-like module	30	15
ABC transporter transmembrane region	ABC transporter transmembrane region	29	6
RING/U-box	TRAF domain-like	28	14
DBL homology domain (DH-domain)	PH domain-like	28	19
Hairpin loop containing domain-like	Fibrinogen C-terminal domain-like	27	10
SRCR-like	SRCR-like	27	9
Concanavalin A-like lectins/glucanases	EGF/Laminin	27	24
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	27	11
CalX-like	CalX-like	26	16
WD40 repeat-like	WD40 repeat-like	26	15
F-box domain	RNI-like	26	9
Thioredoxin-like	GST C-terminal domain-like	25	2
Homeodomain-like	Homeodomain-like	25	16
B-box zinc-binding domain	E set domains	25	12
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	23	10
Complement control module/SCR domain	Complement control module/SCR domain	22	16
Ubiquitin-like	PH domain-like	21	13
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	21	2
Kazal-type serine protease inhibitors	Kazal-type serine protease inhibitors	21	10
RING/U-box	RING/U-box	21	14
Ubiquitin-like	Second domain of FERM	21	12
RNI-like	RNI-like	21	8
PH domain-like	Second domain of FERM	21	13
HAD-like	Calcium ATPase, transmembrane domain M	20	6
EGF/Laminin	Galactose-binding domain-like	20	14
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	20	14
Calcium ATPase, transduction domain A	HAD-like	19	5
Thioredoxin-like	Thioredoxin-like	19	11
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	19	5
PH domain-like	PH domain-like	19	16
vWA-like	vWA-like	19	13
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	19	4
Voltage-gated potassium channels	cAMP-binding domain-like	19	9
Metalloproteases ("zincins"), catalytic domain	TSP-1 type 1 repeat	18	15
Voltage-gated potassium channels	Periplasmic binding protein-like II	18	7
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	18	6
ARM repeat	Protein kinase-like (PK-like)	18	13
RING/U-box	E set domains	18	8
Glucocorticoid receptor-like (DNA-binding domain)	Nuclear receptor ligand-binding domain	18	3
MFS general substrate transporter	MFS general substrate transporter	17	5
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	17	3
Zn-dependent exopeptidases	Transferrin receptor-like dimerisation domain	17	2
EGF/Laminin	Fibrinogen C-terminal domain-like	17	8
E set domains	NHL repeat	17	8
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	17	3
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	17	3
L domain-like	Family A G protein-coupled receptor-like	17	6
TRAF domain-like	TRAF domain-like	17	9
GroEL equatorial domain-like	GroEL apical domain-like	17	4
Cyclin-like	Cyclin-like	16	4
PDZ domain-like	PDZ domain-like	16	14
Spectrin repeat	Spectrin repeat	16	16
Thyroglobulin type-1 domain	Thyroglobulin type-1 domain	16	3
FYVE/PHD zinc finger	FYVE/PHD zinc finger	16	12
Actin depolymerizing proteins	Actin depolymerizing proteins	16	12
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	16	6
Hairpin loop containing domain-like	EGF/Laminin	16	11
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	16	9
SH3-domain	SH3-domain	16	12
PA domain	Zn-dependent exopeptidases	16	2
Cadherin-like	EGF/Laminin	15	11
B-box zinc-binding domain	NHL repeat	15	6
PA domain	Transferrin receptor-like dimerisation domain	15	1
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	15	10
PGBD-like	Metalloproteases ("zincins"), catalytic domain	15	5
Kelch motif	Kelch motif	15	8
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	14	6
Thiolase-like	Thiolase-like	14	2
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	14	5
cAMP-binding domain-like	cAMP-binding domain-like	14	8
GroEL equatorial domain-like	GroEL-intermediate domain like	14	3
RING/U-box	NHL repeat	14	5
BAR/IMD domain-like	SH3-domain	14	8
Tudor/PWWP/MBT	Tudor/PWWP/MBT	13	12
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	13	4
(Trans)glycosidases	Glycosyl hydrolase domain	13	6
GroEL-intermediate domain like	GroEL apical domain-like	13	2
GroES-like	NAD(P)-binding Rossmann-fold domains	13	1
EGF/Laminin	YWTD domain	13	11
Family A G protein-coupled receptor-like	Family A G protein-coupled receptor-like	13	6
Pentapeptide repeat-like	Pentapeptide repeat-like	12	7
Guanido kinase N-terminal domain	Glutamine synthetase/guanido kinase	12	4
PH domain-like	SH3-domain	12	12
Hairpin loop containing domain-like	Concanavalin A-like lectins/glucanases	12	5
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	12	12
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	12	10
Ubiquitin-like	Ubiquitin-like	12	11
Protein kinase-like (PK-like)	Nucleotide cyclase	11	3
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	11	5
C-type lectin-like	C-type lectin-like	11	8
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	11	3
Nucleic acid-binding proteins	Nucleic acid-binding proteins	11	10
F-box domain	WD40 repeat-like	11	6
E set domains	E set domains	11	10
Galactose-binding domain-like	(Trans)glycosidases	11	5
WD40 repeat-like	Quinoprotein alcohol dehydrogenase-like	11	10
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	10	3
Histone-fold	Histone-fold	10	2
PreATP-grasp domain	Rudiment single hybrid motif	10	7
P-loop containing nucleoside triphosphate hydrolases	DEATH domain	10	10
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	10	4
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	10	4
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	10	7
CoA-dependent acyltransferases	CoA-dependent acyltransferases	10	2
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	10	5
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	10	2
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	10	5
Fibronectin type III	Voltage-gated potassium channels	10	10
SH3-domain	P-loop containing nucleoside triphosphate hydrolases	9	9
P-loop containing nucleoside triphosphate hydrolases	TPR-like	9	7
Subtilisin-like	Galactose-binding domain-like	9	4
lambda repressor-like DNA-binding domains	Homeodomain-like	9	2
L domain-like	L domain-like	9	8
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	9	6
WW domain	WW domain	9	8
PH domain-like	GTPase activation domain, GAP	9	8
Periplasmic binding protein-like I	Periplasmic binding protein-like II	9	7
POZ domain	POZ domain	9	7
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	9	7
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	9	4
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	9	5
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	9	4
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	9	7
Protease propeptides/inhibitors	Subtilisin-like	9	4
Concanavalin A-like lectins/glucanases	C-type lectin-like	8	7
LDL receptor-like module	YWTD domain	8	8
FYVE/PHD zinc finger	Bromodomain	8	6
Hairpin loop containing domain-like	Galactose-binding domain-like	8	5
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	8	8
TPR-like	HCP-like	8	8
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	8	7
Metalloproteases ("zincins"), catalytic domain	Concanavalin A-like lectins/glucanases	8	2
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	8	8
EF-hand	PLC-like phosphodiesterases	8	8
Fibronectin type III	Concanavalin A-like lectins/glucanases	8	7
Nucleotide-diphospho-sugar transferases	Ricin B-like lectins	8	2
RNI-like	EF-hand	8	4
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	8	3
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	8	5
MFS general substrate transporter	Kazal-type serine protease inhibitors	8	2
PHM/PNGase F	PHM/PNGase F	8	3
Spermadhesin, CUB domain	EGF/Laminin	8	8
Calponin-homology domain, CH-domain	Spectrin repeat	8	8
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	8	2
Purple acid phosphatase, N-terminal domain	Metallo-dependent phosphatases	8	3
SET domain	beta-beta-alpha zinc fingers	8	5
Ribonuclease H-like	DNA/RNA polymerases	8	7
P-loop containing nucleoside triphosphate hydrolases	SMAD/FHA domain	8	6
HLH, helix-loop-helix DNA-binding domain	PYP-like sensor domain (PAS domain)	8	6
UBA-like	Ubiquitin-like	8	8
Zn-dependent exopeptidases	Carboxypeptidase regulatory domain-like	7	3
vWA-like	EGF/Laminin	7	5
TSP-1 type 1 repeat	Fibronectin type III	7	7
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	7	5
Cadherin-like	Concanavalin A-like lectins/glucanases	7	7
Galactose oxidase, central domain	Kelch motif	7	4
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	7	6
PDZ domain-like	SH3-domain	7	7
LDL receptor-like module	EGF/Laminin	7	7
RING/U-box	WD40 repeat-like	7	5
DEATH domain	DEATH domain	7	7
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	7	5
BRCT domain	BRCT domain	7	7
Insect cysteine-rich antifreeze protein	Insect cysteine-rich antifreeze protein	7	4
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	7	4
PH domain-like	(Phosphotyrosine protein) phosphatases II	7	5
Cullin homology domain	"Winged helix" DNA-binding domain	7	3
Cysteine-rich domain	Cysteine-rich domain	7	6
Periplasmic binding protein-like I	Growth factor receptor domain	7	3
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	7	4
Protease propeptides/inhibitors	Galactose-binding domain-like	7	2
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	7	3
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	7	4
Kazal-type serine protease inhibitors	EF-hand	7	5
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	7	4
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	7	2
Invertebrate chitin-binding proteins	Invertebrate chitin-binding proteins	7	7
Complement control module/SCR domain	EGF/Laminin	7	7
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	7	4
PDZ domain-like	Ubiquitin-like	6	6
PreATP-grasp domain	Single hybrid motif	6	3
Cullin repeat-like	Cullin homology domain	6	2
Periplasmic binding protein-like I	Protein kinase-like (PK-like)	6	5
RING/U-box	Cysteine proteinases	6	5
Cullin repeat-like	"Winged helix" DNA-binding domain	6	2
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	6	2
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	6	1
Nucleotide cyclase	EAL domain-like	6	3
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	6	6
PH domain-like	ArfGap/RecO-like zinc finger	6	6
Growth factor receptor domain	Concanavalin A-like lectins/glucanases	6	6
"Winged helix" DNA-binding domain	E2F-DP heterodimerization region	6	3
dsRNA-binding domain-like	dsRNA-binding domain-like	6	6
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	6	4
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	6	3
EF-G C-terminal domain-like	EF-G C-terminal domain-like	6	5
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	6	5
POZ domain	Galactose oxidase, central domain	6	3
HLH, helix-loop-helix DNA-binding domain	Orange domain-like	6	3
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	6	3
YWTD domain	Growth factor receptor domain	6	6
ARM repeat	WD40 repeat-like	6	6
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	6	5
GAF domain-like	GAF domain-like	6	4
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	6	5
Ligand-binding domain in the NO signalling and Golgi transport	Nucleotide cyclase	6	2
PDZ domain-like	P-loop containing nucleoside triphosphate hydrolases	6	6
Galactose-binding domain-like	Fibronectin type III	6	6
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	6	2
PH domain-like	SH2 domain	6	4
P-loop containing nucleoside triphosphate hydrolases	RNI-like	6	5
PH domain-like	FYVE/PHD zinc finger	6	6
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	6	3
FAS1 domain	FAS1 domain	6	5
PKD domain	PKD domain	6	6
"Winged helix" DNA-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	6	1
SH3-domain	DBL homology domain (DH-domain)	6	6
Cysteine-rich domain	Protein kinase-like (PK-like)	6	5
Glucocorticoid receptor-like (DNA-binding domain)	Homeodomain-like	6	4
L domain-like	Growth factor receptor domain	6	5
PDZ domain-like	PH domain-like	6	6
BEACH domain	WD40 repeat-like	6	5
PAZ domain	Ribonuclease H-like	6	4
Rudiment single hybrid motif	Single hybrid motif	6	3
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	6	4
L27 domain	PDZ domain-like	6	6
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	5	5
Metalloproteases ("zincins"), catalytic domain	Blood coagulation inhibitor (disintegrin)	5	2
Translation proteins	EF-G C-terminal domain-like	5	4
Ankyrin repeat	ARM repeat	5	5
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	5	4
Cysteine proteinases	Ubiquitin-like	5	4
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	5	1
Metalloproteases ("zincins"), catalytic domain	Hemopexin-like domain	5	3
PH domain-like	Cysteine-rich domain	5	5
Fibrinogen C-terminal domain-like	Fibrinogen C-terminal domain-like	5	3
PH domain-like	BEACH domain	5	3
Rhodanese/Cell cycle control phosphatase	(Phosphotyrosine protein) phosphatases II	5	1
Folate-binding domain	Aminomethyltransferase beta-barrel domain	5	3
Metalloproteases ("zincins"), catalytic domain	Metalloproteases ("zincins"), catalytic domain	5	4
Protein kinase-like (PK-like)	P-loop containing nucleoside triphosphate hydrolases	5	5
SAM/Pointed domain	SAM/Pointed domain	5	4
Concanavalin A-like lectins/glucanases	Spermadhesin, CUB domain	5	5
DEATH domain	Caspase-like	5	4
C2 domain (Calcium/lipid-binding domain, CaLB)	GTPase activation domain, GAP	5	5
vWA-like	Integrin domains	5	3
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	5	5
Growth factor receptor domain	Complement control module/SCR domain	5	5
Galactose-binding domain-like	C-type lectin-like	5	5
E set domains	Voltage-gated potassium channels	5	3
Flavoproteins	Riboflavin synthase domain-like	5	4
DUSP-like	Cysteine proteinases	5	5
t-snare proteins	SNARE fusion complex	5	3
Cysteine-rich domain	C2 domain (Calcium/lipid-binding domain, CaLB)	5	4
Integrin domains	EGF/Laminin	5	3
Fibronectin type III	Protein kinase-like (PK-like)	5	5
"Winged helix" DNA-binding domain	Periplasmic binding protein-like II	5	1
FYVE/PHD zinc finger	DNase I-like	5	3
PX domain	BAR/IMD domain-like	5	2
CHY zinc finger-like	Zinc hairpin stack	5	5
PH domain-like	PLC-like phosphodiesterases	5	5
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	5	3
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	5	5
Plexin repeat	Integrin domains	5	3
Spermadhesin, CUB domain	Growth factor receptor domain	5	5
Galactose-binding domain-like	Growth factor receptor domain	5	5
LDL receptor-like module	Growth factor receptor domain	5	5
Plexin repeat	EGF/Laminin	5	3
Protease propeptides/inhibitors	Zn-dependent exopeptidases	5	2
Concanavalin A-like lectins/glucanases	Galactose-binding domain-like	5	5
Spectrin repeat	EF-hand	5	5
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	5	1
WD40 repeat-like	SOCS box-like	5	3
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	5	5
DEATH domain	TPR-like	5	5
(Trans)glycosidases	Chitinase insertion domain	5	1
GAF domain-like	HD-domain/PDEase-like	5	3
PH domain-like	EF-hand	5	5
HMG-box	HMG-box	5	3
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	5	2
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	5	3
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	5	5
Plexin repeat	vWA-like	5	3
TSP-1 type 1 repeat	Voltage-gated potassium channels	4	4
Spectrin repeat	PH domain-like	4	4
Chromo domain-like	Chromo domain-like	4	3
Concanavalin A-like lectins/glucanases	P-loop containing nucleoside triphosphate hydrolases	4	2
Ubiquitin-like	Protein kinase-like (PK-like)	4	4
P-loop containing nucleoside triphosphate hydrolases	Myosin rod fragments	4	4
SH2 domain	SH3-domain	4	4
EF-hand	Mitochondrial carrier	4	2
Nucleoside diphosphate kinase, NDK	Nucleoside diphosphate kinase, NDK	4	3
FYVE/PHD zinc finger	Cysteine proteinases	4	3
Thioredoxin-like	Ubiquitin-like	4	4
Adhesin YadA, collagen-binding domain	Adhesin YadA, collagen-binding domain	4	1
Doublecortin (DC)	Doublecortin (DC)	4	4
Clavaminate synthase-like	FYVE/PHD zinc finger	4	4
BAR/IMD domain-like	PH domain-like	4	4
P-loop containing nucleoside triphosphate hydrolases	PH domain-like	4	4
RING/U-box	UBA-like	4	4
Cytochrome b5-like heme/steroid binding domain	E set domains	4	2
Translation proteins	Ribosomal protein S5 domain 2-like	4	3
ARM repeat	"Winged helix" DNA-binding domain	4	1
P-loop containing nucleoside triphosphate hydrolases	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	4	3
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	4	4
P-loop containing nucleoside triphosphate hydrolases	RING/U-box	4	3
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	4	4
DNase I-like	DNase I-like	4	4
FAD-linked reductases, C-terminal domain	Aminomethyltransferase beta-barrel domain	4	2
Restriction endonuclease-like	FYVE/PHD zinc finger	4	3
Snake toxin-like	Protein kinase-like (PK-like)	4	1
(Trans)glycosidases	E set domains	4	4
TPR-like	"Winged helix" DNA-binding domain	4	1
Concanavalin A-like lectins/glucanases	RING/U-box	4	3
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	4	4
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	4	4
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	4	4
(Phosphotyrosine protein) phosphatases II	C2 domain (Calcium/lipid-binding domain, CaLB)	4	2
Toll/Interleukin receptor TIR domain	Toll/Interleukin receptor TIR domain	4	3
FAD/NAD(P)-binding domain	Folate-binding domain	4	2
WD40 repeat-like	EF-hand	4	4
Hairpin loop containing domain-like	Hairpin loop containing domain-like	4	4
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	4	2
FAD-linked reductases, C-terminal domain	Folate-binding domain	4	2
BAR/IMD domain-like	GTPase activation domain, GAP	4	4
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	4	3
Myosin S1 fragment, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	4	4
PH domain-like	Ankyrin repeat	4	4
PH domain-like	Ras GEF	4	4
L27 domain	P-loop containing nucleoside triphosphate hydrolases	4	4
L27 domain	SH3-domain	4	4
Ankyrin repeat	Ankyrin repeat	4	4
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	4	2
Ankyrin repeat	P-loop containing nucleoside triphosphate hydrolases	4	4
Periplasmic binding protein-like I	Periplasmic binding protein-like I	4	4
Nucleotide cyclase	Nucleotide cyclase	4	3
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	4	4
YWTD domain	YWTD domain	4	4
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	4	1
Kringle-like	Kringle-like	4	1
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	4	3
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	4	4
Ubiquitin-like	ARM repeat	4	3
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	4	4
SH2 domain	SOCS box-like	4	1
Somatomedin B domain	Family A G protein-coupled receptor-like	4	3
TPR-like	RING/U-box	4	3
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	4	3
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	cAMP-binding domain-like	4	1
Phage fibre proteins	Phage fibre proteins	4	3
Cysteine-rich domain	NAD kinase/diacylglycerol kinase-like	4	4
Frizzled cysteine-rich domain	Frizzled cysteine-rich domain	4	3
RING/U-box	CCCH zinc finger	4	4
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipase/lipooxygenase domain (PLAT/LH2 domain)	4	3
Chondroitin AC/alginate lyase	Galactose mutarotase-like	4	3
Sec7 domain	PH domain-like	4	3
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	4	4
Pectin lyase-like	Pectin lyase-like	4	4
Cytochrome b5-like heme/steroid binding domain	Oxidoreductase molybdopterin-binding domain	4	2
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	4	4
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	4	3
Cysteine proteinases	EF-hand	4	2
EGF/Laminin	TB module/8-cys domain	4	4
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	4	2
Protein kinase-like (PK-like)	SAM/Pointed domain	4	3
PH domain-like	WD40 repeat-like	4	3
SNARE-like	SNARE fusion complex	4	2
Metalloproteases ("zincins"), catalytic domain	ARM repeat	4	2
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	4	4
RCC1/BLIP-II	Hect, E3 ligase catalytic domain	4	4
ClpP/crotonase	ClpP/crotonase	4	2
C2 domain (Calcium/lipid-binding domain, CaLB)	vWA-like	4	1
Ankyrin repeat	POZ domain	4	4
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	4	4
PR-1-like	PR-1-like	4	4
Oxidoreductase molybdopterin-binding domain	E set domains	4	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	4	4
GINS helical bundle-like	PriA/YqbF domain	4	2
Clc chloride channel	CBS-domain pair	4	4
Protein kinase-like (PK-like)	SH3-domain	4	4
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	4	2
FAD/NAD(P)-binding domain	Aminomethyltransferase beta-barrel domain	4	2
Ankyrin repeat	SH3-domain	4	3
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	4	4
ARM repeat	Formin homology 2 domain (FH2 domain)	4	3
Galactose-binding domain-like	Immunoglobulin	4	4
WD40 repeat-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	4	4
TSP type-3 repeat	TSP type-3 repeat	4	4
PX domain	SH3-domain	4	3
Immunoglobulin	Protein kinase-like (PK-like)	4	3
SMAD MH1 domain	SMAD/FHA domain	4	2
TSP type-3 repeat	Concanavalin A-like lectins/glucanases	4	4
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	4	3
PH domain-like	ARM repeat	4	4
Complement control module/SCR domain	Concanavalin A-like lectins/glucanases	4	4
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	4	4
Nucleotidylyl transferase	P-loop containing nucleoside triphosphate hydrolases	3	3
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	3	1
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	3	1
CHY zinc finger-like	RING/U-box	3	3
Concanavalin A-like lectins/glucanases	SRCR-like	3	3
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	3	2
MgtE N-terminal domain-like	MgtE N-terminal domain-like	3	3
FnI-like domain	FnI-like domain	3	3
Calponin-homology domain, CH-domain	E set domains	3	3
PurM N-terminal domain-like	PurM C-terminal domain-like	3	3
SEA domain	Fibronectin type III	3	3
Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	3	1
SNARE fusion complex	SNARE fusion complex	3	2
Galactose-binding domain-like	Hect, E3 ligase catalytic domain	3	3
Thiolase-like	FabD/lysophospholipase-like	3	1
RCC1/BLIP-II	Protein kinase-like (PK-like)	3	2
Growth factor receptor domain	SEA domain	3	2
Zinc beta-ribbon	Cyclin-like	3	3
Elafin-like	Elafin-like	3	3
Galactose mutarotase-like	(Trans)glycosidases	3	1
PYP-like sensor domain (PAS domain)	cAMP-binding domain-like	3	2
L domain-like	Immunoglobulin	3	3
Saposin	Saposin	3	2
TSP-1 type 1 repeat	EGF/Laminin	3	3
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	3	3
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	3
Spermadhesin, CUB domain	Immunoglobulin	3	3
Protein kinase-like (PK-like)	Polo-box domain	3	2
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	3	3
P-loop containing nucleoside triphosphate hydrolases	TGS-like	3	1
Ribonuclease H-like	Ribonuclease H-like	3	2
ARM repeat	Subdomain of clathrin and coatomer appendage domain	3	2
Formyltransferase	FMT C-terminal domain-like	3	2
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	3	3
UBA-like	UBA-like	3	3
Guanido kinase N-terminal domain	Guanido kinase N-terminal domain	3	2
SAM/Pointed domain	RING/U-box	3	3
post-HMGL domain-like	Single hybrid motif	3	1
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	3	3
Actin depolymerizing proteins	VHP, Villin headpiece domain	3	3
FKBP-like	EF-hand	3	1
p53-like transcription factors	E set domains	3	3
Galactose mutarotase-like	Glycosyl hydrolase domain	3	1
Glutathione synthetase ATP-binding domain-like	Succinyl-CoA synthetase domains	3	2
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	3	2
alpha-catenin/vinculin-like	alpha-catenin/vinculin-like	3	3
Complement control module/SCR domain	vWA-like	3	3
Protein kinase-like (PK-like)	DEATH domain	3	3
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	3	1
Regulator of G-protein signaling, RGS	PX domain	3	2
ENTH/VHS domain	GAT-like domain	3	2
vWA-like	Helical domain of Sec23/24	3	3
UBC-like	RING/U-box	3	2
RNA-binding domain, RBD	Retrovirus zinc finger-like domains	3	1
vWA-like	Concanavalin A-like lectins/glucanases	3	3
Galactose-binding domain-like	Protein kinase-like (PK-like)	3	3
EGF/Laminin	C-type lectin-like	3	3
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	3	3
Plexin repeat	Integrin beta tail domain	3	2
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	3	3
"Winged helix" DNA-binding domain	FYVE/PHD zinc finger	3	3
RCC1/BLIP-II	RCC1/BLIP-II	3	3
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	3	2
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	3	3
P-loop containing nucleoside triphosphate hydrolases	FYVE/PHD zinc finger	3	3
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	3	3
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	3	2
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	3	3
ArfGap/RecO-like zinc finger	Ankyrin repeat	3	3
PreATP-grasp domain	post-HMGL domain-like	3	1
Concanavalin A-like lectins/glucanases	SEA domain	3	3
RING/U-box	Fibronectin type III	3	2
SGNH hydrolase	DNase I-like	3	2
Zinc hairpin stack	RING/U-box	3	3
B-box zinc-binding domain	Fibronectin type III	3	2
Acetyl-CoA synthetase-like	Acetyl-CoA synthetase-like	3	3
CRAL/TRIO domain	Supernatant protein factor (SPF), C-terminal domain	3	2
RING/U-box	Calcium-dependent phosphotriesterase	3	3
PreATP-grasp domain	Aldolase	3	1
Immunoglobulin	Family A G protein-coupled receptor-like	3	3
P-loop containing nucleoside triphosphate hydrolases	Retrovirus zinc finger-like domains	3	3
HIT/MYND zinc finger-like	SET domain	3	3
TPR-like	Clavaminate synthase-like	3	2
beta-sandwich domain of Sec23/24	vWA-like	3	3
P-loop containing nucleoside triphosphate hydrolases	EF-hand	3	3
GTPase activation domain, GAP	SH3-domain	3	3
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	3	3
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	3	2
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	3	3
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	3	2
Translation proteins SH3-like domain	Nucleic acid-binding proteins	3	2
Ubiquitin-like	RING/U-box	3	3
Tudor/PWWP/MBT	FYVE/PHD zinc finger	3	3
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	3	1
beta-N-acetylhexosaminidase-like domain	E set domains	3	3
WGR domain-like	Domain of poly(ADP-ribose) polymerase	3	3
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	3	3
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	3	3
Rudiment single hybrid motif	post-HMGL domain-like	3	1
Galactose-binding domain-like	alpha/beta-Hydrolases	3	2
Homeodomain-like	RING/U-box	3	3
EGF/Laminin	Integrin beta tail domain	3	2
Translation proteins	Translation proteins	3	2
FKBP-like	TPR-like	3	3
PreATP-grasp domain	Methylglyoxal synthase-like	3	3
CCCH zinc finger	CCCH zinc finger	3	3
Rudiment single hybrid motif	Aldolase	3	1
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	3	2
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	3	3
Integrin domains	Integrin beta tail domain	3	2
Nucleotide-binding domain	Nucleotide-binding domain	3	2
Complement control module/SCR domain	Immunoglobulin	3	3
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	3	3
Calponin-homology domain, CH-domain	Calponin-homology domain, CH-domain	3	3
Ubiquitin-like	Ankyrin repeat	3	3
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	3	2
Calpain large subunit, middle domain (domain III)	EF-hand	3	1
E set domains	Cysteine proteinases	3	2
PYP-like sensor domain (PAS domain)	Voltage-gated potassium channels	3	2
Protein kinase-like (PK-like)	WD40 repeat-like	3	3
Cytidine deaminase-like	Cytidine deaminase-like	3	2
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	3	2
Glutathione synthetase ATP-binding domain-like	Aldolase	3	1
Ubiquitin-like	Ras GEF	3	3
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	3	1
EF-hand	RING/U-box	3	3
HIT/MYND zinc finger-like	TPR-like	3	3
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	3	2
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	3
WD40 repeat-like	FYVE/PHD zinc finger	3	2
Aldolase	post-HMGL domain-like	3	1
Ubiquitin-like	Cysteine-rich domain	3	3
ARM repeat	Concanavalin A-like lectins/glucanases	3	3
WD40 repeat-like	TPR-like	3	3
P-loop containing nucleoside triphosphate hydrolases	POZ domain	3	1
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	3
vWA-like	Integrin beta tail domain	3	2
Sec63 N-terminal domain-like	E set domains	3	2
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	3	2
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	3	2
Amine oxidase N-terminal region	Amine oxidase catalytic domain	3	2
Glucocorticoid receptor-like (DNA-binding domain)	SH3-domain	3	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Nucleotidyltransferase substrate binding subunit/domain	3	3
TPR-like	ARM repeat	3	3
SEA domain	Galactose-binding domain-like	3	3
Bromodomain	Bromodomain	3	3
C2 domain (Calcium/lipid-binding domain, CaLB)	ARM repeat	3	3
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	3	3
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains	Multidrug efflux transporter AcrB transmembrane domain	3	2
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	3	1
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	3	3
beta-sandwich domain of Sec23/24	Zn-finger domain of Sec23/24	3	3
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	3	3
PGBD-like	Hemopexin-like domain	3	2
Glutathione synthetase ATP-binding domain-like	post-HMGL domain-like	3	1
Aconitase iron-sulfur domain	LeuD/IlvD-like	3	1
Cap-Gly domain	Cysteine proteinases	3	2
Zn-finger domain of Sec23/24	vWA-like	3	3
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	3	1
Aldolase	Single hybrid motif	3	1
Toll/Interleukin receptor TIR domain	SAM/Pointed domain	3	2
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	3	1
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	3	2
Leukotriene A4 hydrolase N-terminal domain	ARM repeat	3	1
Succinyl-CoA synthetase domains	NAD(P)-binding Rossmann-fold domains	3	2
ARM repeat	Cysteine proteinases	3	3
Cysteine-rich domain	GTPase activation domain, GAP	3	3
Translation proteins	Initiation factor IF2/eIF5b, domain 3	3	2
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	3	3
Ribonuclease H-like	RuvA domain 2-like	3	3
Calponin-homology domain, CH-domain	EF-hand	3	3
Galactose-binding domain-like	vWA-like	3	3
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	3	1
CRAL/TRIO N-terminal domain	Supernatant protein factor (SPF), C-terminal domain	3	2
ARM repeat	Clathrin adaptor appendage domain	3	2
RING/U-box	PUA domain-like	3	3
PH domain-like	Oxysterol-binding protein-like	3	2
SNF-like	SNF-like	3	1
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	3	3
FYVE/PHD zinc finger	RING/U-box	3	3
Amine oxidase N-terminal region	Amine oxidase N-terminal region	3	2
Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	3	2
Single hybrid motif	CoA-dependent acyltransferases	3	1
PsbU/PolX domain-like	Nucleotidyltransferase	2	2
Tex N-terminal region-like	Ribonuclease H-like	2	2
Sec7 domain	ARM repeat	2	2
Zinc beta-ribbon	Zinc beta-ribbon	2	1
C-type lectin-like	Hairpin loop containing domain-like	2	2
DEATH domain	Immunoglobulin	2	2
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	2	2
Barwin-like endoglucanases	Barwin-like endoglucanases	2	2
Family A G protein-coupled receptor-like	alpha/beta-Hydrolases	2	2
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	2	2
Regulator of G-protein signaling, RGS	Protein kinase-like (PK-like)	2	1
Hedgehog/DD-peptidase	Hedgehog/intein (Hint) domain	2	1
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	2	2
Protein kinase-like (PK-like)	KA1-like	2	2
PYP-like sensor domain (PAS domain)	Homodimeric domain of signal transducing histidine kinase	2	2
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	2	2
FLJ32549 domain-like	FLJ32549 C-terminal domain-like	2	1
F-box domain	Sec7 domain	2	1
CRAL/TRIO domain	Spectrin repeat	2	2
Eukaryotic type KH-domain (KH-domain type I)	Tudor/PWWP/MBT	2	2
Complement control module/SCR domain	Trypsin-like serine proteases	2	2
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	2	2
Sema domain	Plexin repeat	2	2
B-box zinc-binding domain	Calcium-dependent phosphotriesterase	2	2
Immunoglobulin	Toll/Interleukin receptor TIR domain	2	2
Voltage-gated potassium channels	EF-hand	2	2
Nucleotidylyl transferase	Ribosomal protein L25-like	2	2
P-loop containing nucleoside triphosphate hydrolases	RNA-binding domain, RBD	2	2
Glutathione synthetase ATP-binding domain-like	Composite domain of metallo-dependent hydrolases	2	2
CBD9-like	PHM/PNGase F	2	1
Metallo-dependent phosphatases	Metallo-dependent phosphatases	2	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Glutathione synthetase ATP-binding domain-like	2	2
EGF/Laminin	Immunoglobulin	2	2
Growth factor receptor domain	Mannose 6-phosphate receptor domain	2	2
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	2	2
Kringle-like	Galactose-binding domain-like	2	2
SET domain	RuBisCo LSMT C-terminal, substrate-binding domain	2	2
Concanavalin A-like lectins/glucanases	LDL receptor-like module	2	2
P-loop containing nucleoside triphosphate hydrolases	ARM repeat	2	2
L domain-like	P-loop containing nucleoside triphosphate hydrolases	2	2
Carbamate kinase-like	ALDH-like	2	1
CheY-like	C-terminal effector domain of the bipartite response regulators	2	1
LDL receptor-like module	Spermadhesin, CUB domain	2	2
C-type lectin-like	Family A G protein-coupled receptor-like	2	1
cAMP-binding domain-like	"Winged helix" DNA-binding domain	2	2
RNA-binding domain, RBD	S-adenosyl-L-methionine-dependent methyltransferases	2	2
"Winged helix" DNA-binding domain	E set domains	2	1
TATA-box binding protein-like	DNA-glycosylase	2	1
RCC1/BLIP-II	POZ domain	2	2
Cyclophilin-like	RNA-binding domain, RBD	2	2
P-loop containing nucleoside triphosphate hydrolases	PUA domain-like	2	2
Class II aaRS and biotin synthetases	ThrRS/AlaRS common domain	2	2
PDZ domain-like	Second domain of FERM	2	2
E set domains	Pectin lyase-like	2	2
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	2	2
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	2	2
EF-hand	Thyroglobulin type-1 domain	2	2
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	2	2
A DNA-binding domain in eukaryotic transcription factors	Leucine zipper domain	2	2
Kelch motif	EGF/Laminin	2	2
Calponin-homology domain, CH-domain	GAS2 domain-like	2	1
S15/NS1 RNA-binding domain	Class II aaRS ABD-related	2	2
Homeodomain-like	FAD-linked reductases, C-terminal domain	2	2
PreATP-grasp domain	Metallo-dependent hydrolases	2	2
Glucocorticoid receptor-like (DNA-binding domain)	AN1-like Zinc finger	2	1
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	2	1
P-loop containing nucleoside triphosphate hydrolases	CarD-like	2	2
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	2	2
RuvA domain 2-like	RuvA domain 2-like	2	2
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	2	2
PABC (PABP) domain	PABC (PABP) domain	2	2
Galactose-binding domain-like	Galactose mutarotase-like	2	2
ALDH-like	ALDH-like	2	1
DBL homology domain (DH-domain)	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	1
Ypt/Rab-GAP domain of gyp1p	Rhodanese/Cell cycle control phosphatase	2	2
CAD & PB1 domains	RING/U-box	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheY-like	2	2
Mib/herc2 domain-like	Galactose-binding domain-like	2	2
SAP domain	Restriction endonuclease-like	2	1
Tex N-terminal region-like	Nucleic acid-binding proteins	2	2
C-type lectin-like	Immunoglobulin	2	2
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	2	1
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	2	2
Taf5 N-terminal domain-like	WD40 repeat-like	2	2
Ankyrin repeat	Ras GEF	2	2
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	2	2
Methylglyoxal synthase-like	Composite domain of metallo-dependent hydrolases	2	2
Calponin-homology domain, CH-domain	DBL homology domain (DH-domain)	2	2
Translation initiation factor IF3, N-terminal domain	Translation initiation factor IF3, C-terminal domain	2	2
NAD(P)-binding Rossmann-fold domains	SCP-like	2	2
C2 domain (Calcium/lipid-binding domain, CaLB)	PX domain	2	2
UBA-like	Cysteine proteinases	2	2
Phage tail proteins	Phage tail proteins	2	2
SAM/Pointed domain	PH domain-like	2	2
cAMP-binding domain-like	Ras GEF	2	2
FLJ32549 domain-like	FLJ32549 domain-like	2	1
Acetyl-CoA synthetase-like	ACP-like	2	2
WW domain	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
Protein kinase-like (PK-like)	Acyl-CoA dehydrogenase NM domain-like	2	2
Carbohydrate-binding domain	(Trans)glycosidases	2	2
"Winged helix" DNA-binding domain	PDZ domain-like	2	2
Metalloproteases ("zincins"), catalytic domain	EGF/Laminin	2	2
TRAF domain-like	WD40 repeat-like	2	2
Translation proteins	ThrRS/AlaRS common domain	2	2
NHL repeat	WD40 repeat-like	2	2
Ubiquitin-like	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	2	2
Integrin alpha N-terminal domain	Integrin domains	2	2
SH2 domain	Ubiquitin-like	2	2
Spectrin repeat	DBL homology domain (DH-domain)	2	2
Ankyrin repeat	RING/U-box	2	1
Immunoglobulin	tRNA-intron endonuclease catalytic domain-like	2	2
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	2	1
Methylglyoxal synthase-like	Cytidine deaminase-like	2	2
Immunoglobulin	Caspase-like	2	2
NAD(P)-binding Rossmann-fold domains	P-loop containing nucleoside triphosphate hydrolases	2	2
lambda integrase-like, N-terminal domain	DNA breaking-rejoining enzymes	2	2
RNI-like	Ubiquitin-like	2	2
(Trans)glycosidases	EGF/Laminin	2	2
SRCR-like	Growth factor receptor domain	2	2
MurCD N-terminal domain	MurD-like peptide ligases, catalytic domain	2	2
DEATH domain	Toll/Interleukin receptor TIR domain	2	2
C2 domain (Calcium/lipid-binding domain, CaLB)	FabD/lysophospholipase-like	2	2
Cytokine	Cytokine	2	2
Class I glutamine amidotransferase-like	Carbamoyl phosphate synthetase, large subunit connection domain	2	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	2	2
Spermadhesin, CUB domain	Galactose-binding domain-like	2	2
MIR domain	IP3 receptor type 1 binding core, domain 2	2	2
EGF/Laminin	Fibronectin type III	2	2
P-loop containing nucleoside triphosphate hydrolases	R3H domain	2	2
FMN-linked oxidoreductases	alpha-helical ferredoxin	2	2
cAMP-binding domain-like	Protein kinase-like (PK-like)	2	2
C-type lectin-like	SEA domain	2	2
Immunoglobulin	Concanavalin A-like lectins/glucanases	2	2
DBL homology domain (DH-domain)	WD40 repeat-like	2	2
Nucleotide-diphospho-sugar transferases	Nucleotide-diphospho-sugar transferases	2	2
SAM/Pointed domain	HD-domain/PDEase-like	2	2
PLP-binding barrel	Alanine racemase C-terminal domain-like	2	1
Growth factor receptor domain	Fibrinogen C-terminal domain-like	2	2
Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	2	2
Enolase N-terminal domain-like	Enolase C-terminal domain-like	2	1
TNF receptor-like	DEATH domain	2	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Carbamoyl phosphate synthetase, large subunit connection domain	2	2
Tropomyosin	Tropomyosin	2	2
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	2	2
ARID-like	Clavaminate synthase-like	2	2
Second domain of FERM	Moesin tail domain	2	1
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Immunoglobulin	TSP-1 type 1 repeat	2	2
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	2	1
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	2	2
Mib/herc2 domain-like	RING/U-box	2	2
RNA-binding domain, RBD	UBA-like	2	2
alpha-helical ferredoxin	Nucleotide-binding domain	2	2
Class I glutamine amidotransferase-like	Glutathione synthetase ATP-binding domain-like	2	2
Carbamoyl phosphate synthetase, large subunit connection domain	Composite domain of metallo-dependent hydrolases	2	2
Spermadhesin, CUB domain	Kelch motif	2	2
EGF/Laminin	Lipase/lipooxygenase domain (PLAT/LH2 domain)	2	2
HCP-like	HCP-like	2	2
Chaperone J-domain	Thioredoxin-like	2	2
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	2	1
RNA-binding domain, RBD	L domain-like	2	2
Class I glutamine amidotransferase-like	PreATP-grasp domain	2	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	2	2
Restriction endonuclease-like	RuvA domain 2-like	2	2
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	2	2
Nucleotidylyl transferase	S15/NS1 RNA-binding domain	2	2
Tryptophan synthase beta subunit-like PLP-dependent enzymes	CBS-domain pair	2	1
Inosine monophosphate dehydrogenase (IMPDH)	Inosine monophosphate dehydrogenase (IMPDH)	2	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	2	2
MIR domain	MIR domain	2	2
Thioredoxin-like	ERP29 C domain-like	2	1
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	2	2
ADC-like	P-loop containing nucleoside triphosphate hydrolases	2	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	2	2
Metalloproteases ("zincins"), catalytic domain	Spermadhesin, CUB domain	2	2
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	2	2
FMN-linked oxidoreductases	Nucleotide-binding domain	2	2
GTPase activation domain, GAP	RGC domain-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Second domain of FERM	2	2
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	2	2
Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	2	2
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	2	2
Restriction endonuclease-like	Cysteine proteinases	2	1
CAD & PB1 domains	UBA-like	2	2
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	2	1
AN1-like Zinc finger	AN1-like Zinc finger	2	2
RNA-binding domain, RBD	dsRNA-binding domain-like	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	2
Myosin rod fragments	Myosin rod fragments	2	2
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	2	2
MOSC N-terminal domain-like	PK beta-barrel domain-like	2	1
Methylglyoxal synthase-like	Metallo-dependent hydrolases	2	2
R3H domain	Ribonuclease H-like	2	2
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex, superhelical domain	2	2
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	2	2
HlyD-like secretion proteins	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	2	2
Mannose 6-phosphate receptor domain	Mannose 6-phosphate receptor domain	2	2
Ubiquitin-like	DBL homology domain (DH-domain)	2	2
Concanavalin A-like lectins/glucanases	Voltage-gated potassium channels	2	2
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	2	2
EGF/Laminin	Trypsin-like serine proteases	2	2
SH3-domain	Spectrin repeat	2	2
Phosphoenolpyruvate/pyruvate domain	Thioesterase/thiol ester dehydrase-isomerase	2	2
Tex N-terminal region-like	RuvA domain 2-like	2	2
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	2
Ankyrin repeat	SAM/Pointed domain	2	2
Nucleic acid-binding proteins	TPR-like	2	2
SH2 domain	GTPase activation domain, GAP	2	2
Ribosomal L27 protein-like	Nucleic acid-binding proteins	2	2
E set domains	Calcium-dependent phosphotriesterase	2	2
Tropomyosin	Smc hinge domain	2	2
Mib/herc2 domain-like	Hect, E3 ligase catalytic domain	2	2
Nucleic acid-binding proteins	eIF2alpha middle domain-like	2	1
Trypsin-like serine proteases	PDZ domain-like	2	2
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	2	2
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	2	2
PX domain	Protein kinase-like (PK-like)	2	2
PX domain	Outer arm dynein light chain 1	2	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	2	2
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	2	2
Homodimeric domain of signal transducing histidine kinase	CheY-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	2	1
FYVE/PHD zinc finger	Family A G protein-coupled receptor-like	2	2
Formate/glycerate dehydrogenase catalytic domain-like	DHS-like NAD/FAD-binding domain	2	1
Ubiquitin-like	Ran binding protein zinc finger-like	2	2
TB module/8-cys domain	Growth factor receptor domain	2	2
F-box domain	L domain-like	2	2
MIT domain	Protein kinase-like (PK-like)	2	2
CRAL/TRIO domain	PH domain-like	2	2
PH domain-like	RUN domain-like	2	2
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	2	2
Protein kinase-like (PK-like)	UBA-like	2	2
Periplasmic binding protein-like II	MetI-like	2	2
UBA-like	UBC-like	2	2
PreATP-grasp domain	PreATP-grasp domain	2	2
Translational machinery components	L30e-like	2	2
PH domain-like	Moesin tail domain	2	1
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	2	2
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	2	1
P-loop containing nucleoside triphosphate hydrolases	Glucocorticoid receptor-like (DNA-binding domain)	2	1
Integrin domains	Integrin domains	2	2
Galactose-binding domain-like	Complement control module/SCR domain	2	2
Metalloproteases ("zincins"), catalytic domain	Fibronectin type III	2	2
Ypt/Rab-GAP domain of gyp1p	RUN domain-like	2	2
Family A G protein-coupled receptor-like	DNase I-like	2	2
Calponin-homology domain, CH-domain	PH domain-like	2	2
WW domain	Hect, E3 ligase catalytic domain	2	2
Second domain of FERM	Second domain of FERM	2	2
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	2	2
TPR-like	SET domain	2	2
Second domain of FERM	RING/U-box	2	2
EF-hand	Cysteine-rich domain	2	2
"Winged helix" DNA-binding domain	Ubiquitin-like	2	2
beta-lactamase/transpeptidase-like	beta-lactamase/transpeptidase-like	2	2
UBA-like	Hect, E3 ligase catalytic domain	2	2
Globin-like	Globin-like	2	2
Glutathione synthetase ATP-binding domain-like	Metallo-dependent hydrolases	2	2
SH2 domain	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
Ankyrin repeat	Protein kinase-like (PK-like)	2	2
Growth factor receptor domain	Cadherin-like	2	2
Thioredoxin-like	beta-beta-alpha zinc fingers	2	2
WGR domain-like	ADP-ribosylation	2	2
BRCT domain	Homeodomain-like	2	2
P-loop containing nucleoside triphosphate hydrolases	E set domains	2	1
POZ domain	TRAF domain-like	2	2
WWE domain	Hect, E3 ligase catalytic domain	2	2
Galactose-binding domain-like	Chondroitin AC/alginate lyase	2	2
Ubiquitin-like	Moesin tail domain	2	1
Galactose oxidase, central domain	Galactose oxidase, central domain	2	2
CalX-like	Concanavalin A-like lectins/glucanases	2	2
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	2	1
HMA, heavy metal-associated domain	HAD-like	2	2
RNase III domain-like	dsRNA-binding domain-like	2	2
PH domain-like	"Winged helix" DNA-binding domain	2	2
Carbohydrate-binding domain	E set domains	2	2
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	2	2
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	2	1
Granulin repeat	Granulin repeat	2	2
WW domain	EF-hand	2	2
EF-hand	SH3-domain	2	2
SRCR-like	L domain-like	2	2
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	2	2
CheY-like	P-loop containing nucleoside triphosphate hydrolases	2	2
S15/NS1 RNA-binding domain	Class II aaRS and biotin synthetases	2	2
Polo-box domain	Polo-box domain	2	1
Carbohydrate-binding domain	beta-N-acetylhexosaminidase-like domain	2	2
Mitochondrial carrier	Pentapeptide repeat-like	2	2
Kringle-like	Protein kinase-like (PK-like)	2	2
Immunoglobulin	DNase I-like	2	2
CRAL/TRIO domain	DBL homology domain (DH-domain)	2	2
Protein kinase-like (PK-like)	NTF2-like	2	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	PreATP-grasp domain	2	2
Phospholipase D/nuclease	Phospholipase D/nuclease	2	2
L domain-like	RNI-like	2	2
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	2	1
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	2	1
Terpenoid cyclases/Protein prenyltransferases	Alpha-macroglobulin receptor domain	2	2
RuvA domain 2-like	Nucleic acid-binding proteins	2	2
F-box domain	Pectin lyase-like	2	2
WD40 repeat-like	Cyclophilin-like	2	1
FAS1 domain	EGF/Laminin	2	2
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	2	2
SMAD/FHA domain	SMAD/FHA domain	2	2
F-box domain	Concanavalin A-like lectins/glucanases	2	2
Galactose-binding domain-like	TSP-1 type 1 repeat	2	2
DBL homology domain (DH-domain)	GTPase activation domain, GAP	2	2
BAR/IMD domain-like	Cysteine-rich domain	2	2
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	2	1
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	2	2
TB module/8-cys domain	TB module/8-cys domain	2	2
cAMP-binding domain-like	Ubiquitin-like	2	2
CAD & PB1 domains	Protein kinase-like (PK-like)	2	2
Glutaminase/Asparaginase	Ankyrin repeat	2	1
NAD(P)-binding Rossmann-fold domains	DHS-like NAD/FAD-binding domain	2	1
Concanavalin A-like lectins/glucanases	TSP-1 type 1 repeat	2	2
Ribonuclease H-like	Nucleic acid-binding proteins	2	2
Methyl-accepting chemotaxis protein (MCP) signaling domain	Methyl-accepting chemotaxis protein (MCP) signaling domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	2	2
Growth factor receptor domain	Fibronectin type III	2	2
Cysteine proteinases	Cysteine proteinases	2	2
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	2	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	2	2
S-adenosyl-L-methionine-dependent methyltransferases	Putative methyltransferase TM0872, insert domain	2	2
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	2	1
Chaperone J-domain	Homeodomain-like	2	1
Barwin-like endoglucanases	Invertebrate chitin-binding proteins	2	2
Cap-Gly domain	Cap-Gly domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Tudor/PWWP/MBT	2	2
Trefoil	Trefoil	2	2
PH domain-like	Protein kinase-like (PK-like)	2	2
PreATP-grasp domain	Composite domain of metallo-dependent hydrolases	2	2
B-box zinc-binding domain	P-loop containing nucleoside triphosphate hydrolases	2	1
Homeodomain-like	FAD/NAD(P)-binding domain	2	2
B-box zinc-binding domain	Concanavalin A-like lectins/glucanases	2	1
Cadherin-like	Dystroglycan, domain 2	2	2
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	2	1
ADC-like	Cdc48 domain 2-like	2	1
Frizzled cysteine-rich domain	TIMP-like	2	1
Carbamoyl phosphate synthetase, large subunit connection domain	Metallo-dependent hydrolases	2	2
Peptidase/esterase 'gauge' domain	alpha/beta-Hydrolases	2	2
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	2	2
Chaperone J-domain	RNA-binding domain, RBD	2	2
P-loop containing nucleoside triphosphate hydrolases	Microbial and mitochondrial ADK, insert "zinc finger" domain	2	2
ARM repeat	Hect, E3 ligase catalytic domain	2	2
PDZ domain-like	WW domain	2	2
Protein kinase-like (PK-like)	Acyl-CoA dehydrogenase C-terminal domain-like	2	2
ARM repeat	Toll/Interleukin receptor TIR domain	2	2
ARM repeat	L domain-like	2	2
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	2	1
CSL zinc finger	Chaperone J-domain	1	1
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	1	1
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
ARM repeat	Tudor/PWWP/MBT	1	1
P-loop containing nucleoside triphosphate hydrolases	Ran binding protein zinc finger-like	1	1
Ankyrin repeat	HIT/MYND zinc finger-like	1	1
BPTI-like	Elafin-like	1	1
MFS general substrate transporter	Periplasmic binding protein-like II	1	1
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	1	1
WD40 repeat-like	Cysteine proteinases	1	1
Cobalamin (vitamin B12)-binding domain	Methionine synthase activation domain-like	1	1
Nucleotidylyl transferase	Class II aaRS ABD-related	1	1
RNA-binding domain, RBD	SPOC domain-like	1	1
RNI-like	Fibrinogen C-terminal domain-like	1	1
CalX-like	(Phosphotyrosine protein) phosphatases II	1	1
Ubiquitin-like	Zn-dependent exopeptidases	1	1
EGF/Laminin	SWIB/MDM2 domain	1	1
Restriction endonuclease-like	DEK C-terminal domain	1	1
Surp module (SWAP domain)	ENTH/VHS domain	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	YWTD domain	1	1
Cupredoxins	HAMP domain-like	1	1
beta-N-acetylhexosaminidase-like domain	EGF/Laminin	1	1
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain	WD40 repeat-like	1	1
TSP-1 type 1 repeat	Anthrax protective antigen	1	1
UBA-like	DNase I-like	1	1
PLP-dependent transferases	PreATP-grasp domain	1	1
Porins	P-loop containing nucleoside triphosphate hydrolases	1	1
Epsilon subunit of F1F0-ATP synthase N-terminal domain	Epsilon subunit of F1F0-ATP synthase C-terminal domain	1	1
Ubiquitin-like	SH3-domain	1	1
FnI-like domain	Kringle-like	1	1
DUSP-like	DUSP-like	1	1
p53-like transcription factors	p53 tetramerization domain	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	PKD domain	1	1
Anthrax protective antigen	Family A G protein-coupled receptor-like	1	1
CheY-like	Nucleotidyltransferase	1	1
CCHHC domain	CCHHC domain	1	1
Ankyrin repeat	Second domain of FERM	1	1
SH2 domain	Ras GEF	1	1
EF-hand	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
EF-hand	PX domain	1	1
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	1	1
alpha/beta knot	Nucleic acid-binding proteins	1	1
vWA-like	Growth factor receptor domain	1	1
RNA-binding domain, RBD	PAP/OAS1 substrate-binding domain	1	1
Galactose-binding domain-like	BRCT domain	1	1
FMN-linked oxidoreductases	4Fe-4S ferredoxins	1	1
Pentein	Translation proteins	1	1
Urease, gamma-subunit	Composite domain of metallo-dependent hydrolases	1	1
FYVE/PHD zinc finger	GroEL apical domain-like	1	1
Homocysteine S-methyltransferase	Dihydropteroate synthetase-like	1	1
BEACH domain	FYVE/PHD zinc finger	1	1
SH3-domain	DEATH domain	1	1
RAP domain-like	RAP domain-like	1	1
CAD & PB1 domains	PDZ domain-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	S15/NS1 RNA-binding domain	1	1
CRAL/TRIO N-terminal domain	(Phosphotyrosine protein) phosphatases II	1	1
Family A G protein-coupled receptor-like	ABC transporter transmembrane region	1	1
Surp module (SWAP domain)	Ubiquitin-like	1	1
P-loop containing nucleoside triphosphate hydrolases	MOP-like	1	1
FYVE/PHD zinc finger	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Pre-PUA domain	PUA domain-like	1	1
SRCR-like	LDL receptor-like module	1	1
Actin-like ATPase domain	CheY-like	1	1
Nitric oxide (NO) synthase oxygenase domain	Riboflavin synthase domain-like	1	1
PurS-like	Class I glutamine amidotransferase-like	1	1
SAP domain	DNase I-like	1	1
WD40 repeat-like	TolB, C-terminal domain	1	1
GST C-terminal domain-like	GST C-terminal domain-like	1	1
HIT-like	HIT-like	1	1
L27 domain	L27 domain	1	1
SH3-domain	beta-beta-alpha zinc fingers	1	1
Nitric oxide (NO) synthase oxygenase domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Ribonuclease PH domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
RING/U-box	Hect, E3 ligase catalytic domain	1	1
Thioredoxin-like	FAD-dependent thiol oxidase	1	1
Surp module (SWAP domain)	Surp module (SWAP domain)	1	1
NAD kinase/diacylglycerol kinase-like	CheY-like	1	1
vWA-like	SAP domain	1	1
RUN domain-like	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
Chromo domain-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
Cytochrome b5-like heme/steroid binding domain	Tudor/PWWP/MBT	1	1
EPT/RTPC-like	EPT/RTPC-like	1	1
Histone-fold	Ankyrin repeat	1	1
Notch domain	Notch domain	1	1
ISP domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
Eukaryotic type KH-domain (KH-domain type I)	HD-domain/PDEase-like	1	1
SMAD/FHA domain	dsRNA-binding domain-like	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
Nqo1 middle domain-like	Nqo1C-terminal domain-like	1	1
Serine protease inhibitors	Serine protease inhibitors	1	1
SRCR-like	Spermadhesin, CUB domain	1	1
RING/U-box	Tricorn protease domain 2	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	LDL receptor-like module	1	1
Phosphofructokinase	Phosphofructokinase	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Fibronectin type III	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoglycerate mutase-like	1	1
Concanavalin A-like lectins/glucanases	FnI-like domain	1	1
HAD-like	Acyl-CoA dehydrogenase NM domain-like	1	1
Calcium-dependent phosphotriesterase	YWTD domain	1	1
Clathrin heavy-chain terminal domain	ARM repeat	1	1
PLP-dependent transferases	PLP-dependent transferases	1	1
SAP domain	SAP domain	1	1
F-box domain	Fibronectin type III	1	1
UBC-like	Ribosomal protein S5 domain 2-like	1	1
MIT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Ypt/Rab-GAP domain of gyp1p	SH3-domain	1	1
NAD(P)-binding Rossmann-fold domains	RING/U-box	1	1
C-type lectin-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
L domain-like	WD40 repeat-like	1	1
ARM repeat	POZ domain	1	1
RNI-like	Phospholipase A2, PLA2	1	1
Thioredoxin-like	FabD/lysophospholipase-like	1	1
Ubiquitin-like	XPC-binding domain	1	1
TPR-like	OmpA-like	1	1
Class I glutamine amidotransferase-like	Composite domain of metallo-dependent hydrolases	1	1
"Winged helix" DNA-binding domain	GroEL apical domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
vWA-like	SPOC domain-like	1	1
vWA-like	PR-1-like	1	1
TIMP-like	TIMP-like	1	1
Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Methenyltetrahydrofolate cyclohydrolase-like	1	1
Cytochrome b5-like heme/steroid binding domain	UBA-like	1	1
FAD/NAD(P)-binding domain	Calponin-homology domain, CH-domain	1	1
HAMP domain-like	Nucleotide cyclase	1	1
NHL repeat	BPTI-like	1	1
Spermadhesin, CUB domain	Trypsin-like serine proteases	1	1
BRCT domain	ADP-ribosylation	1	1
TPR-like	MgtE N-terminal domain-like	1	1
Growth factor receptor domain	TNF receptor-like	1	1
Ribosomal protein S5 domain 2-like	Nucleic acid-binding proteins	1	1
Growth factor receptor domain	TSP type-3 repeat	1	1
TAZ domain	Bromodomain	1	1
HAD-like	Protein kinase-like (PK-like)	1	1
vWA-like	SRCR-like	1	1
RING/U-box	Galactose-binding domain-like	1	1
I/LWEQ domain	alpha-catenin/vinculin-like	1	1
Ricin B-like lectins	Immunoglobulin	1	1
RING/U-box	Cyclophilin-like	1	1
TSP-1 type 1 repeat	Cadherin-like	1	1
RING/U-box	SH3-domain	1	1
Acetyl-CoA synthetase-like	Quinoprotein alcohol dehydrogenase-like	1	1
CheW-like	CheY-like	1	1
PUG domain-like	Ubiquitin-like	1	1
SH2 domain	Cysteine-rich domain	1	1
Calponin-homology domain, CH-domain	Concanavalin A-like lectins/glucanases	1	1
C-type lectin-like	ARM repeat	1	1
Adenine nucleotide alpha hydrolases-like	P-loop containing nucleoside triphosphate hydrolases	1	1
EF-hand	Dimeric alpha+beta barrel	1	1
Ribonuclease H-like	SH2 domain	1	1
RING/U-box	R3H domain	1	1
P-loop containing nucleoside triphosphate hydrolases	FF domain	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Concanavalin A-like lectins/glucanases	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
Adenine nucleotide alpha hydrolases-like	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	1	1
G protein-binding domain	PH domain-like	1	1
LDL receptor-like module	Galactose-binding domain-like	1	1
Sema domain	GTPase activation domain, GAP	1	1
Rap/Ran-GAP	Rap/Ran-GAP	1	1
Protein kinase-like (PK-like)	Toll/Interleukin receptor TIR domain	1	1
P-loop containing nucleoside triphosphate hydrolases	PLC-like phosphodiesterases	1	1
USP8 N-terminal domain-like	Rhodanese/Cell cycle control phosphatase	1	1
Alkaline phosphatase-like	His-Me finger endonucleases	1	1
Ricin B-like lectins	Alkaline phosphatase-like	1	1
Growth factor receptor domain	Immunoglobulin	1	1
Actin-like ATPase domain	CheW-like	1	1
BRCT domain	post-AAA+ oligomerization domain-like	1	1
Immunoglobulin	Hormone receptor domain	1	1
Histone-fold	POZ domain	1	1
DBL homology domain (DH-domain)	FYVE/PHD zinc finger	1	1
UBA-like	Tudor/PWWP/MBT	1	1
Periplasmic binding protein-like II	Nucleotide cyclase	1	1
G protein-binding domain	G protein-binding domain	1	1
CRAL/TRIO domain	(Phosphotyrosine protein) phosphatases II	1	1
P-loop containing nucleoside triphosphate hydrolases	Alkaline phosphatase-like	1	1
Hairpin loop containing domain-like	Kringle-like	1	1
Acyl-CoA binding protein	Ankyrin repeat	1	1
Ricin B-like lectins	Spermadhesin, CUB domain	1	1
Ankyrin repeat	RCC1/BLIP-II	1	1
Kelch motif	Growth factor receptor domain	1	1
Protease propeptides/inhibitors	Protease propeptides/inhibitors	1	1
Calponin-homology domain, CH-domain	DNA/RNA polymerases	1	1
SEA domain	RING/U-box	1	1
Formyltransferase	ACP-like	1	1
Stathmin	Stathmin	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Lipoxigenase	1	1
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	1	1
Kix domain of CBP (creb binding protein)	RING/U-box	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
Second domain of FERM	DBL homology domain (DH-domain)	1	1
Ubiquitin-like	GTPase activation domain, GAP	1	1
TSP-1 type 1 repeat	PR-1-like	1	1
Concanavalin A-like lectins/glucanases	SOCS box-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	WGR domain-like	1	1
RCC1/BLIP-II	UBA-like	1	1
Calponin-homology domain, CH-domain	SH3-domain	1	1
NTF2-like	Fibrinogen C-terminal domain-like	1	1
SAICAR synthase-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
(Trans)glycosidases	Invertebrate chitin-binding proteins	1	1
Nucleic acid-binding proteins	SH2 domain	1	1
EGF/Laminin	SEA domain	1	1
Growth factor receptor domain	Ankyrin repeat	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Zinc beta-ribbon	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	Fibronectin type III	1	1
Porins	Carboxypeptidase regulatory domain-like	1	1
Porins	Porins	1	1
FMN-linked oxidoreductases	dsRNA-binding domain-like	1	1
Sema domain	TSP-1 type 1 repeat	1	1
BRCT domain	DBL homology domain (DH-domain)	1	1
Thioredoxin-like	Nucleoside diphosphate kinase, NDK	1	1
HIT/MYND zinc finger-like	HIT/MYND zinc finger-like	1	1
Calponin-homology domain, CH-domain	SH2 domain	1	1
PreATP-grasp domain	PurM N-terminal domain-like	1	1
Trypsin-like serine proteases	Trypsin-like serine proteases	1	1
Tetrahydrobiopterin biosynthesis enzymes-like	Tetrahydrobiopterin biosynthesis enzymes-like	1	1
Pentapeptide repeat-like	DNase I-like	1	1
DNase I-like	EGF/Laminin	1	1
F-box domain	YccV-like	1	1
FYVE/PHD zinc finger	SET domain	1	1
Ubiquitin-like	ADP-ribosylation	1	1
PH domain-like	Cullin repeat-like	1	1
Spermadhesin, CUB domain	Cadherin-like	1	1
Lipoxigenase	beta-beta-alpha zinc fingers	1	1
DNA polymerase beta, N-terminal domain-like	Restriction endonuclease-like	1	1
RING/U-box	NRDP1 C-terminal domain-like	1	1
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	1	1
Molybdenum cofactor biosynthesis proteins	Adenine nucleotide alpha hydrolases-like	1	1
PLC-like phosphodiesterases	C-type lectin-like	1	1
Protein kinase-like (PK-like)	BEACH domain	1	1
Plexin repeat	E set domains	1	1
Dom34/Pelota N-terminal domain-like	L30e-like	1	1
N-terminal domain of MutM-like DNA repair proteins	S13-like H2TH domain	1	1
Nitrite/Sulfite reductase N-terminal domain-like	Precorrin-8X methylmutase CbiC/CobH	1	1
Voltage-gated potassium channels	Pentapeptide repeat-like	1	1
UBA-like	NSFL1 (p97 ATPase) cofactor p47, SEP domain	1	1
XRCC4, N-terminal domain	XRCC4, C-terminal oligomerization domain	1	1
BRK domain-like	Bromodomain	1	1
Porins	CarD-like	1	1
Periplasmic binding protein-like I	Nucleotide cyclase	1	1
RNA-binding domain, RBD	Nucleotidyltransferase	1	1
CBS-domain pair	cAMP-binding domain-like	1	1
Hypothetical protein c14orf129, hspc210	TPR-like	1	1
Histone-fold	ARM repeat	1	1
E set domains	cAMP-binding domain-like	1	1
SRCR-like	Immunoglobulin	1	1
SEA domain	Family A G protein-coupled receptor-like	1	1
Six-hairpin glycosidases	P-loop containing nucleoside triphosphate hydrolases	1	1
RNA-binding domain, RBD	F-box domain	1	1
MetI-like	MetI-like	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Aspartate/ornithine carbamoyltransferase	1	1
EF-hand	Leucine zipper domain	1	1
Ubiquitin-like	A middle domain of Talin 1	1	1
SAP domain	RING/U-box	1	1
MIT domain	Cysteine proteinases	1	1
Galactose-binding domain-like	SAM/Pointed domain	1	1
Thioredoxin-like	Galactose-binding domain-like	1	1
Caspase-like	Caspase-like	1	1
NAD(P)-binding Rossmann-fold domains	ACT-like	1	1
Domain of poly(ADP-ribose) polymerase	vWA-like	1	1
alpha/beta-Hydrolases	alpha/beta-Hydrolases	1	1
C-type lectin-like	vWA-like	1	1
Mib/herc2 domain-like	Mib/herc2 domain-like	1	1
Quinoprotein alcohol dehydrogenase-like	EF-hand	1	1
EGF/Laminin	Thioesterase/thiol ester dehydrase-isomerase	1	1
WWE domain	ADP-ribosylation	1	1
Trimeric LpxA-like enzymes	ARM repeat	1	1
Lamin A/C globular tail domain	WD40 repeat-like	1	1
Tricorn protease domain 2	TPR-like	1	1
Tropomyosin	Class II aaRS ABD-related	1	1
F-box domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Ubiquitin-like	FYVE/PHD zinc finger	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
RNI-like	Toll/Interleukin receptor TIR domain	1	1
YWTD domain	Fibronectin type III	1	1
Sensory domain-like	PR-1-like	1	1
SEA domain	TPR-like	1	1
RNA-binding domain, RBD	Cysteine proteinases	1	1
Pentapeptide repeat-like	Nucleoside diphosphate kinase, NDK	1	1
alpha/beta-Hydrolases	Oligoxyloglucan reducing end-specific cellobiohydrolase	1	1
Methylglyoxal synthase-like	Aspartate/ornithine carbamoyltransferase	1	1
RNA-binding domain, RBD	PABC (PABP) domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Nucleic acid-binding proteins	1	1
Nucleotidylyl transferase	Nucleotidylyl transferase	1	1
SMAD/FHA domain	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
GST C-terminal domain-like	Nucleotidylyl transferase	1	1
Homocysteine S-methyltransferase	Methionine synthase activation domain-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Protein kinase-like (PK-like)	1	1
Tricorn protease domain 2	ARM repeat	1	1
PAH2 domain	PAH2 domain	1	1
HAMP domain-like	Homodimeric domain of signal transducing histidine kinase	1	1
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	1	1
ARM repeat	Ras GEF	1	1
3-carboxy-cis,cis-mucoante lactonizing enzyme	EGF/Laminin	1	1
Spectrin repeat	WW domain	1	1
Metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	1	1
Glutathione synthetase ATP-binding domain-like	NAD(P)-binding Rossmann-fold domains	1	1
Concanavalin A-like lectins/glucanases	Carbohydrate-binding domain	1	1
RCC1/BLIP-II	Tudor/PWWP/MBT	1	1
PH domain-like	RING/U-box	1	1
PX domain	GTPase activation domain, GAP	1	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
HAD-like	Acyl-CoA dehydrogenase C-terminal domain-like	1	1
Family A G protein-coupled receptor-like	WD40 repeat-like	1	1
(Phosphotyrosine protein) phosphatases II	Nucleic acid-binding proteins	1	1
Kix domain of CBP (creb binding protein)	Bromodomain	1	1
F-box domain	ApaG-like	1	1
Sema domain	E set domains	1	1
SNF-like	Bet v1-like	1	1
Homeodomain-like	SIS domain	1	1
Metalloproteases ("zincins"), catalytic domain	Complement control module/SCR domain	1	1
DBL homology domain (DH-domain)	BAR/IMD domain-like	1	1
Immunoglobulin	Ribonuclease H-like	1	1
Heat shock protein 70kD (HSP70), C-terminal subdomain	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
Pentapeptide repeat-like	Concanavalin A-like lectins/glucanases	1	1
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	1	1
Nucleotide-diphospho-sugar transferases	GHMP Kinase, C-terminal domain	1	1
Protein kinase-like (PK-like)	Ypt/Rab-GAP domain of gyp1p	1	1
P-loop containing nucleoside triphosphate hydrolases	AN1-like Zinc finger	1	1
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	1	1
Protein kinase-like (PK-like)	FAT domain of focal adhesion kinase	1	1
THUMP domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Concanavalin A-like lectins/glucanases	PH domain-like	1	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
Cysteine proteinases	Galactose-binding domain-like	1	1
cAMP-binding domain-like	PDZ domain-like	1	1
TPR-like	UBA-like	1	1
Cytochrome b5-like heme/steroid binding domain	Mib/herc2 domain-like	1	1
Immunoglobulin	Thyroglobulin type-1 domain	1	1
PUA domain-like	Ribosomal protein S5 domain 2-like	1	1
Ankyrin repeat	FAD-binding/transporter-associated domain-like	1	1
PreATP-grasp domain	Aspartate/ornithine carbamoyltransferase	1	1
Nucleotide-diphospho-sugar transferases	Poly A polymerase C-terminal region-like	1	1
Chaperone J-domain	UBA-like	1	1
EF-hand	GAF domain-like	1	1
Succinyl-CoA synthetase domains	Citrate synthase	1	1
Porins	Homeodomain-like	1	1
DNA/RNA polymerases	MFS general substrate transporter	1	1
Rap/Ran-GAP	PDZ domain-like	1	1
UBA-like	XPC-binding domain	1	1
RING/U-box	Fibrinogen C-terminal domain-like	1	1
RNA-binding domain, RBD	NTF2-like	1	1
(Trans)glycosidases	Six-hairpin glycosidases	1	1
P-loop containing nucleoside triphosphate hydrolases	Nucleotidyltransferase	1	1
PurM C-terminal domain-like	Class I glutamine amidotransferase-like	1	1
PDZ domain-like	Cysteine-rich domain	1	1
Ribonuclease PH domain 2-like	Nucleic acid-binding proteins	1	1
TRAF domain-like	NRDP1 C-terminal domain-like	1	1
DNase I-like	GTPase activation domain, GAP	1	1
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	1	1
PLP-dependent transferases	Glutathione synthetase ATP-binding domain-like	1	1
PGBD-like	L,D-transpeptidase catalytic domain-like	1	1
Immunoglobulin	(Phosphotyrosine protein) phosphatases II	1	1
Ubiquitin-like	Zn-binding ribosomal proteins	1	1
Thioesterase/thiol ester dehydrase-isomerase	Bet v1-like	1	1
CAD & PB1 domains	Six-hairpin glycosidases	1	1
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	1	1
dsRNA-binding domain-like	R3H domain	1	1
Multiheme cytochromes	Family A G protein-coupled receptor-like	1	1
Nucleotide-diphospho-sugar transferases	Nucleotidyltransferase	1	1
TPR-like	Immunoglobulin	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Metallo-dependent hydrolases	1	1
BRCT domain	Domain of poly(ADP-ribose) polymerase	1	1
TSP-1 type 1 repeat	vWA-like	1	1
Cysteine proteinases	Transglutaminase, two C-terminal domains	1	1
PLP-dependent transferases	Rudiment single hybrid motif	1	1
IP3 receptor type 1 binding core, domain 2	IP3 receptor type 1 binding core, domain 2	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1	1
vWA-like	Di-copper centre-containing domain	1	1
USP8 N-terminal domain-like	WW domain	1	1
Immunoglobulin	Kringle-like	1	1
C-type lectin-like	Putative cyclase	1	1
PH domain-like	RNI-like	1	1
C-terminal, gelsolin-like domain of Sec23/24	Actin depolymerizing proteins	1	1
Homeodomain-like	JAB1/MPN domain	1	1
EF-hand	Kelch motif	1	1
Phase 1 flagellin	Phase 1 flagellin	1	1
Quinoprotein alcohol dehydrogenase-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
L domain-like	Fibronectin type III	1	1
Ubiquitin-like	PX domain	1	1
PRP4-like	WD40 repeat-like	1	1
Kazal-type serine protease inhibitors	FnI-like domain	1	1
PUA domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
RNA-binding domain, RBD	DPP6 N-terminal domain-like	1	1
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	1	1
Thioredoxin-like	AraD/HMP-PK domain-like	1	1
cAMP-binding domain-like	FabD/lysophospholipase-like	1	1
Ubiquitin-like	FAD-binding/transporter-associated domain-like	1	1
Dcp2 domain-like	Nudix	1	1
STAT	p53-like transcription factors	1	1
Thioredoxin-like	Family A G protein-coupled receptor-like	1	1
SAP domain	Ribonuclease H-like	1	1
CBS-domain pair	Nucleotide-diphospho-sugar transferases	1	1
SMAD/FHA domain	Protein kinase-like (PK-like)	1	1
SH2 domain	Ankyrin repeat	1	1
PreATP-grasp domain	PurM C-terminal domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	GTPase activation domain, GAP	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
His-Me finger endonucleases	DNA/RNA polymerases	1	1
PUG domain-like	Cysteine proteinases	1	1
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	1	1
vWA-like	Cysteine proteinases	1	1
Ubiquitin-like	NAD kinase/diacylglycerol kinase-like	1	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	1	1
SH3-domain	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Band 7/SPFH domain	SCP-like	1	1
beta-beta-alpha zinc fingers	WW domain	1	1
BAR/IMD domain-like	Ankyrin repeat	1	1
ENT-like	Bromodomain	1	1
HD-domain/PDEase-like	HD-domain/PDEase-like	1	1
PR-1-like	SOCS box-like	1	1
PurS-like	FGAM synthase PurL, linker domain	1	1
SH2 domain	PLC-like phosphodiesterases	1	1
Fibronectin type III	Anthrax protective antigen	1	1
TPR-like	HSP20-like chaperones	1	1
P-loop containing nucleoside triphosphate hydrolases	S-adenosyl-L-methionine-dependent methyltransferases	1	1
P-loop containing nucleoside triphosphate hydrolases	Prokaryotic type KH domain (KH-domain type II)	1	1
G protein-binding domain	Cysteine-rich domain	1	1
Tropomyosin	RNI-like	1	1
HMA, heavy metal-associated domain	Cu,Zn superoxide dismutase-like	1	1
RING/U-box	DUSP-like	1	1
Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	1	1
Galactose-binding domain-like	Family A G protein-coupled receptor-like	1	1
EF-hand	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	ARM repeat	1	1
Fibronectin type III	CalX-like	1	1
E set domains	Cupredoxins	1	1
Clavaminate synthase-like	Tudor/PWWP/MBT	1	1
CSL zinc finger	CSL zinc finger	1	1
Second domain of FERM	(Phosphotyrosine protein) phosphatases II	1	1
EGF/Laminin	Phosphoenolpyruvate/pyruvate domain	1	1
F-box domain	Voltage-gated potassium channels	1	1
alpha-helical ferredoxin	4Fe-4S ferredoxins	1	1
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	1	1
PRTase-like	Ribulose-phoshate binding barrel	1	1
SAP domain	RNA-binding domain, RBD	1	1
F-box domain	SMI1/KNR4-like	1	1
RNase III domain-like	RNase III domain-like	1	1
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	1	1
ISP domain	Ferritin-like	1	1
RUN domain-like	PDZ domain-like	1	1
GTPase activation domain, GAP	ARM repeat	1	1
GTPase activation domain, GAP	Bet v1-like	1	1
EGF/Laminin	Notch domain	1	1
GMP synthetase C-terminal dimerisation domain	GMP synthetase C-terminal dimerisation domain	1	1
Formin homology 2 domain (FH2 domain)	Formin homology 2 domain (FH2 domain)	1	1
L domain-like	Actin depolymerizing proteins	1	1
EF-hand	Tropomyosin	1	1
Myosin S1 fragment, N-terminal domain	Myosin rod fragments	1	1
Doublecortin (DC)	Protein kinase-like (PK-like)	1	1
Homeodomain-like	Nucleotide cyclase	1	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	1	1
FF domain	FF domain	1	1
FGAM synthase PurL, linker domain	PurM N-terminal domain-like	1	1
ARM repeat	BEACH domain	1	1
FabD/lysophospholipase-like	EF-hand	1	1
BRCT domain	PH domain-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ATP-dependent DNA ligase DNA-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	RuvA domain 2-like	1	1
Calponin-homology domain, CH-domain	ARM repeat	1	1
Intermediate filament protein, coiled coil region	Intermediate filament protein, coiled coil region	1	1
Ribonuclease H-like	Fibronectin type III	1	1
Retrovirus zinc finger-like domains	Acid proteases	1	1
Tubby C-terminal domain-like	DNA/RNA polymerases	1	1
mRNA decapping enzyme DcpS N-terminal domain	HIT-like	1	1
"Winged helix" DNA-binding domain	SAICAR synthase-like	1	1
Complement control module/SCR domain	C-type lectin-like	1	1
Urease, beta-subunit	Composite domain of metallo-dependent hydrolases	1	1
V-type ATP synthase subunit C	Thioesterase/thiol ester dehydrase-isomerase	1	1
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	S15/NS1 RNA-binding domain	1	1
Ribosomal protein L25-like	Class II aaRS ABD-related	1	1
EGF/Laminin	TSP type-3 repeat	1	1
Ribosomal protein L25-like	C-terminal domain of ProRS	1	1
Kelch motif	BAR/IMD domain-like	1	1
UBC-like	Class II aaRS and biotin synthetases	1	1
PH domain-like	NAD kinase/diacylglycerol kinase-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	alpha-helical ferredoxin	1	1
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	1	1
E set domains	Galactose-binding domain-like	1	1
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	1	1
Clc chloride channel	Clc chloride channel	1	1
Ypt/Rab-GAP domain of gyp1p	EGF/Laminin	1	1
Thioredoxin-like	NHL repeat	1	1
Second domain of FERM	Ras GEF	1	1
LDL receptor-like module	Lipovitellin-phosvitin complex; beta-sheet shell regions	1	1
TROVE domain-like	vWA-like	1	1
Ribosomal protein S5 domain 2-like	Ribulose-phoshate binding barrel	1	1
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	1	1
GYF domain	Chaperone J-domain	1	1
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	1	1
POZ domain	WD40 repeat-like	1	1
G protein-binding domain	FYVE/PHD zinc finger	1	1
TPR-like	RNA-binding domain, RBD	1	1
Ubiquitin-like	Hect, E3 ligase catalytic domain	1	1
EGF/Laminin	beta-beta-alpha zinc fingers	1	1
BRCA2 helical domain	Nucleic acid-binding proteins	1	1
MFS general substrate transporter	PH domain-like	1	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	1	1
Chaperone J-domain	Nucleotidyltransferase substrate binding subunit/domain	1	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	1	1
PLC-like phosphodiesterases	C-terminal domain of PLC-beta	1	1
Anthrax protective antigen	Anthrax protective antigen	1	1
WD40 repeat-like	MFS general substrate transporter	1	1
SAP domain	Family A G protein-coupled receptor-like	1	1
Dihydropteroate synthetase-like	Methionine synthase activation domain-like	1	1
Methylated DNA-protein cysteine methyltransferase domain	Methylated DNA-protein cysteine methyltransferase, C-terminal domain	1	1
Protein kinase-like (PK-like)	(Phosphotyrosine protein) phosphatases II	1	1
SMAD/FHA domain	RING/U-box	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
Dihydropteroate synthetase-like	Methionine synthase domain	1	1
(Phosphotyrosine protein) phosphatases II	FYVE/PHD zinc finger	1	1
STAT	SH2 domain	1	1
PUG domain-like	Ran binding protein zinc finger-like	1	1
Concanavalin A-like lectins/glucanases	WD40 repeat-like	1	1
beta-beta-alpha zinc fingers	Nucleotidyltransferase	1	1
GAF domain-like	PYP-like sensor domain (PAS domain)	1	1
tRNA-guanine transglycosylase	tRNA-guanine transglycosylase	1	1
Isocitrate/Isopropylmalate dehydrogenase-like	HlyD-like secretion proteins	1	1
CCCH zinc finger	RNA-binding domain, RBD	1	1
SH3-domain	Toll/Interleukin receptor TIR domain	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	CalX-like	1	1
ARID-like	FYVE/PHD zinc finger	1	1
PLP-dependent transferases	Adenine nucleotide alpha hydrolases-like	1	1
Putative DNA-binding domain	Putative DNA-binding domain	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	1	1
EAL domain-like	Composite domain of metallo-dependent hydrolases	1	1
Fibronectin type III	Thioredoxin-like	1	1
P-loop containing nucleoside triphosphate hydrolases	CYTH-like phosphatases	1	1
L domain-like	ADP-ribosylglycohydrolase	1	1
Glutathione synthetase ATP-binding domain-like	PurM N-terminal domain-like	1	1
GYF domain	ARM repeat	1	1
Tudor/PWWP/MBT	Hect, E3 ligase catalytic domain	1	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	1	1
HR1 repeat	Protein kinase-like (PK-like)	1	1
Homocysteine S-methyltransferase	Cobalamin (vitamin B12)-binding domain	1	1
HCP-like	Cyclin-like	1	1
IP3 receptor type 1 binding core, domain 2	ARM repeat	1	1
Nucleotidylyl transferase	Nucleic acid-binding proteins	1	1
Ricin B-like lectins	Galactose-binding domain-like	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
RNI-like	Fibronectin type III	1	1
RCC1/BLIP-II	Galactose-binding domain-like	1	1
Bacterial hemolysins	RING/U-box	1	1
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	1	1
Concanavalin A-like lectins/glucanases	BEACH domain	1	1
CHY zinc finger-like	CHY zinc finger-like	1	1
E set domains	Glycosyl hydrolase domain	1	1
ENTH/VHS domain	SH3-domain	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	1	1
Tudor/PWWP/MBT	S-adenosyl-L-methionine-dependent methyltransferases	1	1
L domain-like	UBA-like	1	1
RING/U-box	Trimerization domain of TRAF	1	1
Lipoxigenase	Lipoxigenase	1	1
Microbial and mitochondrial ADK, insert "zinc finger" domain	Microbial and mitochondrial ADK, insert "zinc finger" domain	1	1
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	1	1
Putative DNA-binding domain	SAND domain-like	1	1
Dehydroquinate synthase-like	LysM domain	1	1
dsRNA-binding domain-like	Nudix	1	1
PP2C-like	Protein serine/threonine phosphatase 2C, C-terminal domain	1	1
Eukaryotic type KH-domain (KH-domain type I)	Pentein	1	1
UBA-like	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	1	1
Cytochrome b5-like heme/steroid binding domain	Hect, E3 ligase catalytic domain	1	1
Nitrite and sulphite reductase 4Fe-4S domain-like	CbiG N-terminal domain-like	1	1
Restriction endonuclease-like	EGF/Laminin	1	1
PurM N-terminal domain-like	Formyltransferase	1	1
PH domain-like	A middle domain of Talin 1	1	1
Cobalamin (vitamin B12)-dependent enzymes	Cobalamin (vitamin B12)-dependent enzymes	1	1
L domain-like	NTF2-like	1	1
Metallo-hydrolase/oxidoreductase	Macro domain-like	1	1
Homeodomain-like	HAMP domain-like	1	1
PLP-dependent transferases	MOSC N-terminal domain-like	1	1
ENTH/VHS domain	Clathrin adaptor appendage domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	1	1
YccV-like	ApaG-like	1	1
RCC1/BLIP-II	PABC (PABP) domain	1	1
Bcl-2 inhibitors of programmed cell death	Invertebrate chitin-binding proteins	1	1
Immunoglobulin	MFS general substrate transporter	1	1
RING/U-box	Hairpin loop containing domain-like	1	1
Eukaryotic type KH-domain (KH-domain type I)	LigT-like	1	1
Concanavalin A-like lectins/glucanases	Glucocorticoid receptor-like (DNA-binding domain)	1	1
Chondroitin AC/alginate lyase	Hyaluronate lyase-like, C-terminal domain	1	1
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	1	1
PRTase-like	PRTase-like	1	1
Agglutinin HPA-like	Kazal-type serine protease inhibitors	1	1
Ribonuclease H-like	MFS general substrate transporter	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
Glucocorticoid receptor-like (DNA-binding domain)	ADP-ribosylation	1	1
Fibronectin type III	Hect, E3 ligase catalytic domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
Starch-binding domain-like	(Phosphotyrosine protein) phosphatases II	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Composite domain of metallo-dependent hydrolases	1	1
Complement control module/SCR domain	TSP-1 type 1 repeat	1	1
Second domain of FERM	FAT domain of focal adhesion kinase	1	1
TIMP-like	Concanavalin A-like lectins/glucanases	1	1
F-box domain	Fibrinogen C-terminal domain-like	1	1
Concanavalin A-like lectins/glucanases	Fibrinogen C-terminal domain-like	1	1
CBS-domain pair	MgtE membrane domain-like	1	1
ARM repeat	SAM/Pointed domain	1	1
Phage fibre proteins	(Phosphotyrosine protein) phosphatases II	1	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	1	1
PurS-like	PurM N-terminal domain-like	1	1
Elongation factor Ts (EF-Ts), dimerisation domain	Elongation factor Ts (EF-Ts), dimerisation domain	1	1
(Trans)glycosidases	Restriction endonuclease-like	1	1
TPR-like	Fic-like	1	1
DEATH domain	WD40 repeat-like	1	1
DNA/RNA polymerases	Zinc finger domain of DNA polymerase-alpha	1	1
Ubiquitin-like	alpha-catenin/vinculin-like	1	1
Class I glutamine amidotransferase-like	Metallo-dependent hydrolases	1	1
Galactose mutarotase-like	Hyaluronate lyase-like, C-terminal domain	1	1
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	1	1
Ribonuclease H-like	EGF/Laminin	1	1
UBC-like	Protein kinase-like (PK-like)	1	1
Calcyclin-binding protein-like	HSP20-like chaperones	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
ARM repeat	PX domain	1	1
FGAM synthase PurL, linker domain	PurM C-terminal domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	PEBP-like	1	1
Transmembrane di-heme cytochromes	Radical SAM enzymes	1	1
UBA-like	RNI-like	1	1
WD40 repeat-like	RCC1/BLIP-II	1	1
FYVE/PHD zinc finger	SMAD/FHA domain	1	1
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	1	1
Calponin-homology domain, CH-domain	Glucocorticoid receptor-like (DNA-binding domain)	1	1
RNI-like	Galactose-binding domain-like	1	1
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	1	1
SH3-domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
FAD-linked reductases, C-terminal domain	EF-hand	1	1
Ubiquitin-like	(Phosphotyrosine protein) phosphatases II	1	1
DBL homology domain (DH-domain)	SH2 domain	1	1
Trypsin-like serine proteases	DEATH domain	1	1
EF-hand	FnI-like domain	1	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Ribokinase-like	1	1
PIN domain-like	Nucleic acid-binding proteins	1	1
Actin-like ATPase domain	NAD kinase/diacylglycerol kinase-like	1	1
"Winged helix" DNA-binding domain	Dimeric alpha+beta barrel	1	1
EF-hand	GAS2 domain-like	1	1
WD40 repeat-like	SAM/Pointed domain	1	1
PDZ domain-like	Ras GEF	1	1
DNA breaking-rejoining enzymes	Nucleic acid-binding proteins	1	1
PH domain-like	RCC1/BLIP-II	1	1
Ubiquitin-like	BAG domain	1	1
FYVE/PHD zinc finger	SAP domain	1	1
SH2 domain	SH2 domain	1	1
AbfB domain	Kringle-like	1	1
NAD(P)-binding Rossmann-fold domains	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
DEK C-terminal domain	SWIB/MDM2 domain	1	1
Second domain of FERM	A middle domain of Talin 1	1	1
F-box domain	Galactose-binding domain-like	1	1
Growth factor receptor domain	Protein kinase-like (PK-like)	1	1
FMN-linked oxidoreductases	Galactose-binding domain-like	1	1
E set domains	EGF/Laminin	1	1
PABC (PABP) domain	Hect, E3 ligase catalytic domain	1	1
Periplasmic binding protein-like II	Protein kinase-like (PK-like)	1	1
E set domains	Terpenoid cyclases/Protein prenyltransferases	1	1
HlyD-like secretion proteins	Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains	1	1
Cyclophilin-like	TPR-like	1	1
EAL domain-like	Metallo-dependent hydrolases	1	1
Nitric oxide (NO) synthase oxygenase domain	Flavoproteins	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	LysM domain	1	1
R3H domain	AN1-like Zinc finger	1	1
EF-hand	DUSP-like	1	1
Macro domain-like	CRAL/TRIO domain	1	1
WW domain	FF domain	1	1
Periplasmic binding protein-like I	Voltage-gated potassium channels	1	1
P-loop containing nucleoside triphosphate hydrolases	Fzo-like conserved region	1	1
Thioredoxin-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
ARM repeat	Family A G protein-coupled receptor-like	1	1
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, dispensable insert domain	1	1
Second domain of FERM	Protein kinase-like (PK-like)	1	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	1	1
UBA-like	KA1-like	1	1
FMT C-terminal domain-like	ALDH-like	1	1
MIT domain	Calpain large subunit, middle domain (domain III)	1	1
Urease, gamma-subunit	Urease, beta-subunit	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Ankyrin repeat	1	1
PR-1-like	WD40 repeat-like	1	1
Cupredoxins	Pectin lyase-like	1	1
Adenine nucleotide alpha hydrolases-like	Translation proteins	1	1
PH domain-like	alpha-catenin/vinculin-like	1	1
PDZ domain-like	Concanavalin A-like lectins/glucanases	1	1
F-box domain	PH domain-like	1	1
WD40 repeat-like	Ribonuclease H-like	1	1
DNA primase core	P-loop containing nucleoside triphosphate hydrolases	1	1
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains	1	1
WD40 repeat-like	Tricorn protease domain 2	1	1
L domain-like	SAM/Pointed domain	1	1
Ribulose-phoshate binding barrel	all-alpha NTP pyrophosphatases	1	1
ParB/Sulfiredoxin	KorB DNA-binding domain-like	1	1
Alpha subunit of glutamate synthase, C-terminal domain	alpha-helical ferredoxin	1	1
Cytochrome b5-like heme/steroid binding domain	RING/U-box	1	1
Ubiquitin-like	I/LWEQ domain	1	1
F-box domain	RING/U-box	1	1
Protein kinase-like (PK-like)	Class II aaRS and biotin synthetases	1	1
UBC-like	Endosomal sorting complex assembly domain	1	1
Ubiquitin-like	Cap-Gly domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Cobalamin (vitamin B12)-dependent enzymes	1	1
AF0104/ALDC/Ptd012-like	AF0104/ALDC/Ptd012-like	1	1
Cytochrome b5-like heme/steroid binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Phage tail proteins	gp5 N-terminal domain-like	1	1
E set domains	AMPKBI-like	1	1
WD40 repeat-like	SNARE fusion complex	1	1
dsRNA-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Glucocorticoid receptor-like (DNA-binding domain)	Domain of poly(ADP-ribose) polymerase	1	1
Rudiment single hybrid motif	PurM N-terminal domain-like	1	1
EGF/Laminin	V-type ATP synthase subunit C	1	1
PYP-like sensor domain (PAS domain)	CheY-like	1	1
ARM repeat	beta-sandwich domain of Sec23/24	1	1
ARM repeat	EF-hand	1	1
Fibronectin type III	Periplasmic binding protein-like II	1	1
TPR-like	Ankyrin repeat	1	1
A middle domain of Talin 1	alpha-catenin/vinculin-like	1	1
Outer arm dynein light chain 1	L domain-like	1	1
PH domain-like	Regulator of G-protein signaling, RGS	1	1
Growth factor receptor domain	Notch domain	1	1
Calpain large subunit, middle domain (domain III)	Calpain large subunit, middle domain (domain III)	1	1
P-loop containing nucleoside triphosphate hydrolases	Phospholipase A2, PLA2	1	1
PH domain-like	FAT domain of focal adhesion kinase	1	1
P-loop containing nucleoside triphosphate hydrolases	SH2 domain	1	1
HAMP domain-like	EAL domain-like	1	1
PDZ domain-like	ClpP/crotonase	1	1
Homocysteine S-methyltransferase	Methionine synthase domain	1	1
Clavaminate synthase-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Nucleotidylyl transferase	Class II aaRS and biotin synthetases	1	1
Hypothetical protein c14orf129, hspc210	ARM repeat	1	1
S-adenosyl-L-methionine-dependent methyltransferases	YebC-like	1	1
TNF-like	TNF-like	1	1
Cysteine proteinases	HIT/MYND zinc finger-like	1	1
Plexin repeat	TSP-1 type 1 repeat	1	1
Protein kinase-like (PK-like)	PDZ domain-like	1	1
Ankyrin repeat	Cap-Gly domain	1	1
MFS general substrate transporter	Ribulose-phoshate binding barrel	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Ribosomal protein L6	Ribosomal protein L6	1	1
TSP-1 type 1 repeat	Periplasmic binding protein-like II	1	1
Spectrin repeat	RING/U-box	1	1
TRAF domain-like	TPR-like	1	1
ArfGap/RecO-like zinc finger	SH3-domain	1	1
Concanavalin A-like lectins/glucanases	Protein kinase-like (PK-like)	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
Cytochrome c oxidase subunit I-like	Cytochrome c	1	1
Subtilisin-like	Subtilisin-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Macro domain-like	1	1
L domain-like	PDZ domain-like	1	1
Ribosomal protein L25-like	Class II aaRS and biotin synthetases	1	1
Fibrinogen C-terminal domain-like	Fibronectin type III	1	1
C-type lectin-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
BPTI-like	Serine protease inhibitors	1	1
PDZ domain-like	Formin homology 2 domain (FH2 domain)	1	1
Lipovitellin-phosvitin complex; beta-sheet shell regions	Lipovitellin-phosvitin complex; beta-sheet shell regions	1	1
Concanavalin A-like lectins/glucanases	DNase I-like	1	1
L domain-like	RING/U-box	1	1
Calponin-homology domain, CH-domain	Ankyrin repeat	1	1
Protein kinase-like (PK-like)	L27 domain	1	1
POZ domain	Pentapeptide repeat-like	1	1
SEA domain	Voltage-gated potassium channels	1	1
E set domains	Hect, E3 ligase catalytic domain	1	1
Nucleic acid-binding proteins	BRCT domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Periplasmic binding protein-like II	1	1
PDZ domain-like	EF-hand	1	1
PH domain-like	Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	1	1
GAF domain-like	Phosphoglucomutase, first 3 domains	1	1
R3H domain	Ankyrin repeat	1	1
L domain-like	Protein kinase-like (PK-like)	1	1
S15/NS1 RNA-binding domain	C-terminal domain of ProRS	1	1
P-loop containing nucleoside triphosphate hydrolases	Ubiquitin-like	1	1
TPR-like	CBS-domain pair	1	1
ACT-like	ACT-like	1	1
Rhodanese/Cell cycle control phosphatase	WW domain	1	1
Ran binding protein zinc finger-like	RING/U-box	1	1
tRNA-binding arm	Class II aaRS and biotin synthetases	1	1
Protein kinase-like (PK-like)	HCP-like	1	1
MIT domain	MIT domain	1	1
Kringle-like	Concanavalin A-like lectins/glucanases	1	1
Concanavalin A-like lectins/glucanases	Serine protease inhibitors	1	1
(Phosphotyrosine protein) phosphatases II	Cysteine-rich domain	1	1
I/LWEQ domain	I/LWEQ domain	1	1
Quinoprotein alcohol dehydrogenase-like	Ypt/Rab-GAP domain of gyp1p	1	1
Alpha-L RNA-binding motif	Pseudouridine synthase	1	1
Metalloproteases ("zincins"), catalytic domain	C-type lectin-like	1	1
Seven-hairpin glycosidases	Seven-hairpin glycosidases	1	1
WD40 repeat-like	DPP6 N-terminal domain-like	1	1
NAP-like	Ankyrin repeat	1	1
Nucleic acid-binding proteins	Retrovirus zinc finger-like domains	1	1
Calpain large subunit, middle domain (domain III)	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	1	1
RNA-binding domain, RBD	TSP-1 type 1 repeat	1	1
Nucleotidylyl transferase	C-terminal domain of ProRS	1	1
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	1	1
vWA-like	FYVE/PHD zinc finger	1	1
A heparin-binding domain	CAPPD, an extracellular domain of amyloid beta A4 protein	1	1
PH domain-like	Ran binding protein zinc finger-like	1	1
DBL homology domain (DH-domain)	SGNH hydrolase	1	1
Formyltransferase	ALDH-like	1	1
Cytochrome c	4Fe-4S ferredoxins	1	1
Translation proteins SH3-like domain	Translation proteins SH3-like domain	1	1
MgtE N-terminal domain-like	CBS-domain pair	1	1
HLH, helix-loop-helix DNA-binding domain	HMG-box	1	1
RING/U-box	WWE domain	1	1
RNA-binding domain, RBD	Surp module (SWAP domain)	1	1
Fibronectin type III	Complement control module/SCR domain	1	1
Concanavalin A-like lectins/glucanases	ADP-ribosylation	1	1
PA domain	RING/U-box	1	1
Ankyrin repeat	Heat shock protein 70kD (HSP70), C-terminal subdomain	1	1
WD40 repeat-like	Hect, E3 ligase catalytic domain	1	1
Galactose-binding domain-like	Voltage-gated potassium channels	1	1
Cytochrome P450	Cytochrome P450	1	1
PreATP-grasp domain	Formyltransferase	1	1
PH domain-like	Bet v1-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Smc hinge domain	1	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	1	1
Calponin-homology domain, CH-domain	Thioredoxin-like	1	1
Clavaminate synthase-like	Tetraspanin	1	1
Nucleotide cyclase	Composite domain of metallo-dependent hydrolases	1	1
vWA-like	Trypsin-like serine proteases	1	1
Glutathione synthetase ATP-binding domain-like	Aspartate/ornithine carbamoyltransferase	1	1
F-box domain	HCP-like	1	1
P-loop containing nucleoside triphosphate hydrolases	vWA-like	1	1
PH domain-like	C-terminal domain of PLC-beta	1	1
P-loop containing nucleoside triphosphate hydrolases	Bet v1-like	1	1
CAD & PB1 domains	Cysteine-rich domain	1	1
EGF/Laminin	TIMP-like	1	1
Ankyrin repeat	FYVE/PHD zinc finger	1	1
Thioredoxin-like	Six-hairpin glycosidases	1	1
Trefoil	EGF/Laminin	1	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	1	1
FMT C-terminal domain-like	ACP-like	1	1
B-box zinc-binding domain	TRAF domain-like	1	1
RCC1/BLIP-II	RING/U-box	1	1
HR1 repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	1	1
WD40 repeat-like	Bromodomain	1	1
beta-beta-alpha zinc fingers	RNA-binding domain, RBD	1	1
P-loop containing nucleoside triphosphate hydrolases	Fibrinogen C-terminal domain-like	1	1
"Winged helix" DNA-binding domain	Transducin (heterotrimeric G protein), gamma chain	1	1
Chaperone J-domain	Sec63 N-terminal domain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Nucleotide-binding domain	1	1
Concanavalin A-like lectins/glucanases	FYVE/PHD zinc finger	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Oligoxyloglucan reducing end-specific cellobiohydrolase	1	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	VPS9 domain	1	1
HSP20-like chaperones	Riboflavin synthase domain-like	1	1
Outer arm dynein light chain 1	WD40 repeat-like	1	1
WW domain	FKBP-like	1	1
MFS general substrate transporter	Ribosomal protein S5 domain 2-like	1	1
Saposin	SGNH hydrolase	1	1
BRK domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Acetyl-CoA synthetase-like	(Trans)glycosidases	1	1
NAD(P)-binding Rossmann-fold domains	Citrate synthase	1	1
Class I glutamine amidotransferase-like	Ribulose-phoshate binding barrel	1	1
CheY-like	Methylesterase CheB, C-terminal domain	1	1
PH domain-like	Ypt/Rab-GAP domain of gyp1p	1	1
RNI-like	Concanavalin A-like lectins/glucanases	1	1
Pseudouridine synthase	PUA domain-like	1	1
Tudor/PWWP/MBT	BRCT domain	1	1
Ypt/Rab-GAP domain of gyp1p	Concanavalin A-like lectins/glucanases	1	1
Thioesterase/thiol ester dehydrase-isomerase	SCP-like	1	1
Ubiquitin-like	Acid proteases	1	1
PKD domain	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
Hormone receptor domain	Family A G protein-coupled receptor-like	1	1
EGF/Laminin	Invertebrate chitin-binding proteins	1	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	1	1
N-terminal domain of MutM-like DNA repair proteins	Glucocorticoid receptor-like (DNA-binding domain)	1	1
Alpha subunit of glutamate synthase, C-terminal domain	Nucleotide-binding domain	1	1
ARM repeat	FYVE/PHD zinc finger	1	1
Ankyrin repeat	FabD/lysophospholipase-like	1	1
Radical SAM enzymes	Molybdenum cofactor biosynthesis protein C, MoaC	1	1
Immunoglobulin	Invertebrate chitin-binding proteins	1	1
TRAF domain-like	Trimerization domain of TRAF	1	1
p53-like transcription factors	DNA-binding protein LAG-1 (CSL)	1	1
RING/U-box	PDZ domain-like	1	1
HAD-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Methionine synthase domain	Methionine synthase activation domain-like	1	1
beta-N-acetylhexosaminidase-like domain	Galactose-binding domain-like	1	1
RmlC-like cupins	RmlC-like cupins	1	1
Immunoglobulin	Frizzled cysteine-rich domain	1	1
Amidase signature (AS) enzymes	Cytokine	1	1
vWA-like	Sensory domain-like	1	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
DEK C-terminal domain	(Phosphotyrosine protein) phosphatases II	1	1
NAD(P)-binding Rossmann-fold domains	NagB/RpiA/CoA transferase-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Type II DNA topoisomerase	1	1
Hairpin loop containing domain-like	SNARE-like	1	1
Actin-like ATPase domain	AF1104-like	1	1
Retrovirus zinc finger-like domains	DNase I-like	1	1
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	1	1
Tudor/PWWP/MBT	Cytokine	1	1
Adhesin YadA, collagen-binding domain	Pseudouridine synthase	1	1
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	1	1
Bromodomain	Tudor/PWWP/MBT	1	1
vWA-like	Hairpin loop containing domain-like	1	1
Nitrite/Sulfite reductase N-terminal domain-like	CbiG N-terminal domain-like	1	1
BRCT domain	DNA/RNA polymerases	1	1
Ribonuclease H-like	Zinc finger domain of DNA polymerase-alpha	1	1
WW domain	NAD(P)-binding Rossmann-fold domains	1	1
SH3-domain	RUN domain-like	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	1	1
UBA-like	Peptidyl-tRNA hydrolase II	1	1
RuvA domain 2-like	F-box domain	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Serine metabolism enzymes domain	1	1
Nitrite and sulphite reductase 4Fe-4S domain-like	Precorrin-8X methylmutase CbiC/CobH	1	1
vWA-like	Immunoglobulin	1	1
Molybdenum cofactor biosynthesis proteins	MoeA N-terminal region -like	1	1
Histone-fold	Macro domain-like	1	1
FKBP-like	FKBP-like	1	1
C-terminal, gelsolin-like domain of Sec23/24	VHP, Villin headpiece domain	1	1
FYVE/PHD zinc finger	EF-hand	1	1
EGF/Laminin	DEK C-terminal domain	1	1
GST C-terminal domain-like	Class II aaRS ABD-related	1	1
Periplasmic binding protein-like II	Periplasmic binding protein-like II	1	1
Chaperone J-domain	ARM repeat	1	1
PK beta-barrel domain-like	PK C-terminal domain-like	1	1
EPT/RTPC-like	RNA 3'-terminal phosphate cyclase, RPTC, insert domain	1	1
Plexin repeat	GTPase activation domain, GAP	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
Tex N-terminal region-like	SH2 domain	1	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	1	1
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	Pyrimidine nucleoside phosphorylase C-terminal domain	1	1
Concanavalin A-like lectins/glucanases	Ricin B-like lectins	1	1
MgtE N-terminal domain-like	MgtE membrane domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Helical scaffold and wing domains of SecA	1	1
Nucleotide-binding domain	4Fe-4S ferredoxins	1	1
L domain-like	DNase I-like	1	1
P-loop containing nucleoside triphosphate hydrolases	EGF/Laminin	1	1
Ribosomal protein L25-like	S15/NS1 RNA-binding domain	1	1
p53-like transcription factors	SH2 domain	1	1
Amyloid beta a4 protein copper binding domain (domain 2)	CAPPD, an extracellular domain of amyloid beta A4 protein	1	1
WD40 repeat-like	E set domains	1	1
FYVE/PHD zinc finger	RNI-like	1	1
XRCC4, C-terminal oligomerization domain	Immunoglobulin	1	1
The spindle assembly checkpoint protein mad2	FYVE/PHD zinc finger	1	1
ARM repeat	CalX-like	1	1
Chaperone J-domain	E set domains	1	1
Restriction endonuclease-like	SWIB/MDM2 domain	1	1
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	1	1
Zn-dependent exopeptidases	Zn-dependent exopeptidases	1	1
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains	1	1
Ankyrin repeat	SOCS box-like	1	1
DNA-binding protein LAG-1 (CSL)	E set domains	1	1
Kelch motif	SH3-domain	1	1
BRCT domain	Lesion bypass DNA polymerase (Y-family), little finger domain	1	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	1	1
E set domains	GTPase activation domain, GAP	1	1
NagB/RpiA/CoA transferase-like	alpha-helical ferredoxin	1	1
SET domain	beta-lactamase/transpeptidase-like	1	1
Cytochrome b5-like heme/steroid binding domain	Galactose-binding domain-like	1	1
Bromodomain	RING/U-box	1	1
EGF/Laminin	Kringle-like	1	1
Aminoacid dehydrogenase-like, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
DNA/RNA polymerases	DNA breaking-rejoining enzymes	1	1
Thioredoxin-like	FAD/NAD(P)-binding domain	1	1
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	Wiscott-Aldrich syndrome protein, WASP, C-terminal domain	1	1
L domain-like	EGF/Laminin	1	1
F-box domain	Kelch motif	1	1
Galactose-binding domain-like	Hyaluronate lyase-like, C-terminal domain	1	1
TNF receptor-like	TNF receptor-like	1	1
E2F-DP heterodimerization region	Alkaline phosphatase-like	1	1
PDZ domain-like	BAR/IMD domain-like	1	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	1	1
Cysteine proteinases	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Rudiment single hybrid motif	PurM C-terminal domain-like	1	1
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
ARM repeat	Fibronectin type III	1	1
MoeA N-terminal region -like	MoeA C-terminal domain-like	1	1
PurM C-terminal domain-like	Formyltransferase	1	1
Adhesin YadA, collagen-binding domain	Tropomyosin	1	1
Apolipoprotein A-I	E set domains	1	1
Rhomboid-like	UBA-like	1	1
EGF/Laminin	Lipoxigenase	1	1
TPR-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Tudor/PWWP/MBT	SET domain	1	1
Ankyrin repeat	PDZ domain-like	1	1
DNA/RNA polymerases	DHH phosphoesterases	1	1
(Trans)glycosidases	Acyl-CoA N-acyltransferases (Nat)	1	1
CBS-domain pair	CBS-domain pair	1	1
"Winged helix" DNA-binding domain	Regulator of G-protein signaling, RGS	1	1
Fibrinogen C-terminal domain-like	TSP-1 type 1 repeat	1	1
Staphylococcal nuclease	Tudor/PWWP/MBT	1	1
Hypothetical protein SAV1430	Fe-S cluster assembly (FSCA) domain-like	1	1
GST C-terminal domain-like	Ribosomal protein L25-like	1	1
Ferredoxin reductase-like, C-terminal NADP-linked domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	ACT-like	1	1
Fibronectin type III	Ankyrin repeat	1	1
RING/U-box	Protein kinase-like (PK-like)	1	1
ARM repeat	Second domain of FERM	1	1
Cysteine proteinases	Ribonuclease H-like	1	1
RING/U-box	ARM repeat	1	1
Transglutaminase, two C-terminal domains	Transglutaminase, two C-terminal domains	1	1
Tubby C-terminal domain-like	His-Me finger endonucleases	1	1
CRAL/TRIO domain	PapD-like	1	1
SH3-domain	PLC-like phosphodiesterases	1	1
RING/U-box	BRCT domain	1	1
S13-like H2TH domain	Glucocorticoid receptor-like (DNA-binding domain)	1	1
Staphylococcal nuclease	Staphylococcal nuclease	1	1
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	1	1
Pectin lyase-like	Tudor/PWWP/MBT	1	1
Pentein	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	1	1
L9 N-domain-like	Ribonuclease H-like	1	1
Elafin-like	Immunoglobulin	1	1
XRCC4, N-terminal domain	Immunoglobulin	1	1
Glutathione synthetase ATP-binding domain-like	PurM C-terminal domain-like	1	1
Glycerol-3-phosphate (1)-acyltransferase	EF-hand	1	1
Galactose-binding domain-like	Bet v1-like	1	1
PUA domain-like	SWIB/MDM2 domain	1	1
TPR-like	PIN domain-like	1	1
WW domain	RING/U-box	1	1
Elongation factor TFIIS domain 2	Zinc beta-ribbon	1	1
beta-beta-alpha zinc fingers	PAP/OAS1 substrate-binding domain	1	1
Tudor/PWWP/MBT	Galactose-binding domain-like	1	1
UBA-like	Ricin B-like lectins	1	1
EGF/Laminin	Tropomyosin	1	1
DEATH domain	NHL repeat	1	1
Cobalamin (vitamin B12)-dependent enzymes	Cobalamin (vitamin B12)-binding domain	1	1
Fibronectin type III	(Phosphotyrosine protein) phosphatases II	1	1
Outer arm dynein light chain 1	Family A G protein-coupled receptor-like	1	1
ARM repeat	WWE domain	1	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	1	1
DEATH domain	SH2 domain	1	1
ISP domain	Bet v1-like	1	1
DNase I-like	C-type lectin-like	1	1
PTPA-like	PTPA-like	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	1	1
ACT-like	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
RING/U-box	RNA-binding domain, RBD	1	1
Glucocorticoid receptor-like (DNA-binding domain)	BRCT domain	1	1
PurS-like	PurM C-terminal domain-like	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Methylglyoxal synthase-like	1	1
Thioredoxin-like	eEF1-gamma domain	1	1
RCC1/BLIP-II	FYVE/PHD zinc finger	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	1	1
GST C-terminal domain-like	C-terminal domain of ProRS	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	C-terminal domain of PLC-beta	1	1
TRAF domain-like	Cysteine proteinases	1	1
SAM/Pointed domain	ArfGap/RecO-like zinc finger	1	1
TSP-1 type 1 repeat	C-type lectin-like	1	1
RNI-like	Voltage-gated potassium channels	1	1
EGF/Laminin	Ankyrin repeat	1	1
Cysteine proteinases	Globin-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	VPS9 domain	1	1
Putative DNA-binding domain	PheT/TilS domain	1	1
alpha/beta-Hydrolases	Carbamate kinase-like	1	1
ACP-like	ALDH-like	1	1
PH domain-like	Glycolipid transfer protein, GLTP	1	1
Bromodomain	HMG-box	1	1
Ribosomal protein S5 domain 2-like	Periplasmic binding protein-like II	1	1
CAD & PB1 domains	His-Me finger endonucleases	1	1
Ankyrin repeat	Hect, E3 ligase catalytic domain	1	1
SMAD/FHA domain	PH domain-like	1	1
NAD kinase/diacylglycerol kinase-like	CheW-like	1	1
Hairpin loop containing domain-like	DNA/RNA polymerases	1	1
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
ARM repeat	Zn-dependent exopeptidases	1	1
Galactose-binding domain-like	Kelch motif	1	1
Spermadhesin, CUB domain	Complement control module/SCR domain	1	1
L30e-like	alpha/beta knot	1	1
PYP-like sensor domain (PAS domain)	Nucleotide cyclase	1	1
L9 N-domain-like	Ribosomal protein L9 C-domain	1	1
Retrovirus zinc finger-like domains	Nucleotidyltransferase	1	1
Ribonuclease H-like	HRDC-like	1	1
SRCR-like	EGF/Laminin	1	1
A middle domain of Talin 1	I/LWEQ domain	1	1
post-AAA+ oligomerization domain-like	post-AAA+ oligomerization domain-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Chaperone J-domain	1	1
Ras GEF	EF-hand	1	1
L domain-like	Hormone receptor domain	1	1
Tudor/PWWP/MBT	CCHHC domain	1	1
Ras GEF	Cysteine-rich domain	1	1
FF domain	GTPase activation domain, GAP	1	1
PurM N-terminal domain-like	Class I glutamine amidotransferase-like	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
Flavoproteins	Radical SAM enzymes	1	1
P-loop containing nucleoside triphosphate hydrolases	Chaperone J-domain	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Aspartate/ornithine carbamoyltransferase	1	1
Glycosyl hydrolase domain	Glycosyl hydrolase domain	1	1
PH domain-like	Phospholipase D/nuclease	1	1
BRCT domain	WGR domain-like	1	1
E set domains	Thioredoxin-like	1	1
POZ domain	Skp1 dimerisation domain-like	1	1
RNA-binding domain, RBD	Ran binding protein zinc finger-like	1	1
PGBD-like	P-loop containing nucleoside triphosphate hydrolases	1	1
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	1	1
Immunoglobulin	Hairpin loop containing domain-like	1	1
SH3-domain	ARM repeat	1	1
TolB, C-terminal domain	TPR-like	1	1
RING/U-box	ADP-ribosylglycohydrolase	1	1
Transducin (heterotrimeric G protein), gamma chain	Regulator of G-protein signaling, RGS	1	1
PHM/PNGase F	NHL repeat	1	1
Hairpin loop containing domain-like	Six-hairpin glycosidases	1	1
Nucleic acid-binding proteins	BRCA2 tower domain	1	1
Acetyl-CoA synthetase-like	Trimeric LpxA-like enzymes	1	1
beta-beta-alpha zinc fingers	Leucine zipper domain	1	1
L21p-like	L21p-like	1	1
NAD kinase/diacylglycerol kinase-like	Ankyrin repeat	1	1
SH3-domain	WW domain	1	1
Family A G protein-coupled receptor-like	Spectrin repeat	1	1
CCHHC domain	Acyl-CoA N-acyltransferases (Nat)	1	1
SIS domain	SIS domain	1	1
EF-hand	C-terminal domain of PLC-beta	1	1
PDZ domain-like	(Phosphotyrosine protein) phosphatases II	1	1
"Winged helix" DNA-binding domain	TSP-1 type 1 repeat	1	1
"Winged helix" DNA-binding domain	Ras GEF	1	1
Clavaminate synthase-like	RNI-like	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain I	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain II	1	1
Notch domain	Ankyrin repeat	1	1
Fibrinogen C-terminal domain-like	Voltage-gated potassium channels	1	1
Homeodomain-like	Cupredoxins	1	1
Ubiquitin-like	HAD-like	1	1
Histone-fold	DBL homology domain (DH-domain)	1	1
Sialidases	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
ISP domain	FAD/NAD(P)-binding domain	1	1
DBL homology domain (DH-domain)	Ras GEF	1	1
TATA-box binding protein-like	TATA-box binding protein-like	1	1
PUG domain-like	Galactose-binding domain-like	1	1
A heparin-binding domain	Amyloid beta a4 protein copper binding domain (domain 2)	1	1
Plexin repeat	Plexin repeat	1	1
R3H domain	RNA-binding domain, RBD	1	1
Trefoil	LDL receptor-like module	1	1
HR1 repeat	PDZ domain-like	1	1
F-box domain	Cyclin-like	1	1
FGAM synthase PurL, linker domain	Class I glutamine amidotransferase-like	1	1
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	1	1
Actin depolymerizing proteins	SH3-domain	1	1
Ribonuclease H-like	RNA-binding domain, RBD	1	1
ENTH/VHS domain	FYVE/PHD zinc finger	1	1
RCC1/BLIP-II	Mib/herc2 domain-like	1	1
Arp2/3 complex subunits	Arp2/3 complex subunits	1	1
F-box domain	DBL homology domain (DH-domain)	1	1
PUA domain-like	Nucleotidylyl transferase	1	1
PheT/TilS domain	Class II aaRS and biotin synthetases	1	1
Outer arm dynein light chain 1	P-loop containing nucleoside triphosphate hydrolases	1	1
UBA-like	Galactose-binding domain-like	1	1
SWIB/MDM2 domain	eIF1-like	1	1
PYP-like sensor domain (PAS domain)	HD-domain/PDEase-like	1	1
Cullin repeat-like	Cullin repeat-like	1	1
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	1	1
Glycerol-3-phosphate (1)-acyltransferase	Cysteine proteinases	1	1
Glucocorticoid receptor-like (DNA-binding domain)	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
Anthrax protective antigen	Voltage-gated potassium channels	1	1
Immunoglobulin	Fibrinogen C-terminal domain-like	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	NagB/RpiA/CoA transferase-like	1	1
"Winged helix" DNA-binding domain	occludin/ELL-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	1	1
EF-hand	NAD kinase/diacylglycerol kinase-like	1	1
DEATH domain	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
FnI-like domain	Serine protease inhibitors	1	1
Voltage-gated potassium channels	NAD(P)-binding Rossmann-fold domains	1	1
FYVE/PHD zinc finger	PUA domain-like	1	1
RUN domain-like	RUN domain-like	1	1
Cupredoxins	EAL domain-like	1	1
PHM/PNGase F	BPTI-like	1	1
SAP domain	Cytochrome b5-like heme/steroid binding domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	MetI-like	1	1
Precorrin-8X methylmutase CbiC/CobH	CbiG N-terminal domain-like	1	1
NTF2-like	UBA-like	1	1
Tudor/PWWP/MBT	EGF/Laminin	1	1
(Trans)glycosidases	(Trans)glycosidases	1	1
NAD(P)-binding Rossmann-fold domains	Thioesterase/thiol ester dehydrase-isomerase	1	1
Intermediate filament protein, coiled coil region	Lamin A/C globular tail domain	1	1
PDZ domain-like	Regulator of G-protein signaling, RGS	1	1
PUG domain-like	RING/U-box	1	1
TSP-1 type 1 repeat	SEA domain	1	1
TPR-like	Tropomyosin	1	1
GroEL apical domain-like	SAICAR synthase-like	1	1
PH domain-like	BSD domain-like	1	1
L domain-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	1	1
TAFH domain-like	Histone-fold	1	1
Second domain of FERM	I/LWEQ domain	1	1
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	1	1
Phospholipase A2, PLA2	Phospholipase A2, PLA2	1	1
Adenine nucleotide alpha hydrolases-like	Type II DNA topoisomerase	1	1
RuvA domain 2-like	SH2 domain	1	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	1	1
DNase I-like	RNA-binding domain, RBD	1	1
TAZ domain	Kix domain of CBP (creb binding protein)	1	1
Urease, beta-subunit	Metallo-dependent hydrolases	1	1
alpha/beta-Hydrolases	Lipase/lipooxygenase domain (PLAT/LH2 domain)	1	1
Formate dehydrogenase/DMSO reductase, domains 1-3	ISP domain	1	1
Metallo-dependent phosphatases	EF-hand	1	1
MurCD N-terminal domain	MurD-like peptide ligases, peptide-binding domain	1	1
Glutathione synthetase ATP-binding domain-like	Citrate synthase	1	1
His-Me finger endonucleases	Ribonuclease H-like	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
LDL receptor-like module	Fibronectin type III	1	1
TSP-1 type 1 repeat	DEATH domain	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
Fibronectin type III	SAM/Pointed domain	1	1
Glucocorticoid receptor-like (DNA-binding domain)	beta-Roll	1	1
Second domain of FERM	SH3-domain	1	1
SMI1/KNR4-like	ApaG-like	1	1
Mib/herc2 domain-like	UBA-like	1	1
V-type ATP synthase subunit C	Phosphoenolpyruvate/pyruvate domain	1	1
MgtE membrane domain-like	MgtE membrane domain-like	1	1
Fibronectin type III	MFS general substrate transporter	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Galactose oxidase, central domain	1	1
ARM repeat	Mib/herc2 domain-like	1	1
RuvA domain 2-like	Pentapeptide repeat-like	1	1
Lipase/lipooxygenase domain (PLAT/LH2 domain)	Voltage-gated potassium channels	1	1
TAZ domain	RING/U-box	1	1
FYVE/PHD zinc finger	Chromo domain-like	1	1
Class I glutamine amidotransferase-like	Aspartate/ornithine carbamoyltransferase	1	1
XRCC4, N-terminal domain	DNase I-like	1	1
lambda repressor-like DNA-binding domains	TNF-like	1	1
PDZ domain-like	PX domain	1	1
Nucleotide cyclase	Metallo-dependent hydrolases	1	1
MIR domain	ARM repeat	1	1
Concanavalin A-like lectins/glucanases	L domain-like	1	1
TPR-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Bet v1-like	HAD-like	1	1
Retrovirus zinc finger-like domains	PAP/OAS1 substrate-binding domain	1	1
Ankyrin repeat	WD40 repeat-like	1	1
POZ domain	Galactose-binding domain-like	1	1
Ankyrin repeat	EF-hand	1	1
DNA-glycosylase	Nudix	1	1
Glutathione synthetase ATP-binding domain-like	Formyltransferase	1	1
beta-sandwich domain of Sec23/24	Formin homology 2 domain (FH2 domain)	1	1
DNA breaking-rejoining enzymes	Eukaryotic DNA topoisomerase I, dispensable insert domain	1	1
P-loop containing nucleoside triphosphate hydrolases	Quinoprotein alcohol dehydrogenase-like	1	1
Thioredoxin-like	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
Multidrug efflux transporter AcrB transmembrane domain	WD40 repeat-like	1	1
Macro domain-like	Zn-dependent exopeptidases	1	1
RuvA domain 2-like	WD40 repeat-like	1	1
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	1	1
Ankyrin repeat	L domain-like	1	1
Activator of Hsp90 ATPase, Aha1	Bet v1-like	1	1
GST C-terminal domain-like	S15/NS1 RNA-binding domain	1	1
P-loop containing nucleoside triphosphate hydrolases	WW domain	1	1
TPR-like	Chaperone J-domain	1	1
E set domains	Transglutaminase, two C-terminal domains	1	1
OmpA-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
P-loop containing nucleoside triphosphate hydrolases	ArfGap/RecO-like zinc finger	1	1
Methionine synthase domain	Cobalamin (vitamin B12)-binding domain	1	1
SRCR-like	Trypsin-like serine proteases	1	1
TAZ domain	TAZ domain	1	1
EGF/Laminin	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
Carboxypeptidase regulatory domain-like	OmpA-like	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	UBA-like	1	1
Multidrug efflux transporter AcrB transmembrane domain	DNA breaking-rejoining enzymes	1	1
FYVE/PHD zinc finger	SAICAR synthase-like	1	1
UBA-like	WWE domain	1	1
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	1	1
NAD(P)-binding Rossmann-fold domains	Serine metabolism enzymes domain	1	1
Ribulose-phoshate binding barrel	Periplasmic binding protein-like II	1	1
Tubby C-terminal domain-like	Ribonuclease H-like	1	1
UBA-like	Thioredoxin-like	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Hect, E3 ligase catalytic domain	1	1
Composite domain of metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	1	1
Tricorn protease domain 2	DPP6 N-terminal domain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	1	1
ADP-ribosylation	vWA-like	1	1
Ubiquitin-like	FAT domain of focal adhesion kinase	1	1
Homeodomain-like	EAL domain-like	1	1
RCC1/BLIP-II	Cytochrome b5-like heme/steroid binding domain	1	1
ARM repeat	Galactose-binding domain-like	1	1
Protein kinase-like (PK-like)	Rhodanese/Cell cycle control phosphatase	1	1
Nucleotide-diphospho-sugar transferases	Ribosomal protein S5 domain 2-like	1	1
ISP transmembrane anchor	ISP domain	1	1
ACP-like	Trimeric LpxA-like enzymes	1	1
CRAL/TRIO N-terminal domain	PapD-like	1	1
SAM/Pointed domain	Ubiquitin-like	1	1
Tetrahydrobiopterin biosynthesis enzymes-like	6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	1	1
HR1 repeat	HR1 repeat	1	1
AbfB domain	AbfB domain	1	1
Second domain of FERM	alpha-catenin/vinculin-like	1	1
"Winged helix" DNA-binding domain	PLP-dependent transferases	1	1
TAFH domain-like	HIT/MYND zinc finger-like	1	1
RNA-binding domain, RBD	Clavaminate synthase-like	1	1
WW domain	PIN domain-like	1	1
WD40 repeat-like	Putative isomerase YbhE	1	1
PDZ domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
RuvA domain 2-like	DNase I-like	1	1
ClpP/crotonase	NAD(P)-binding Rossmann-fold domains	1	1
Spermadhesin, CUB domain	SEA domain	1	1
Fibrinogen C-terminal domain-like	Galactose-binding domain-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	1	1
TPR-like	MgtE membrane domain-like	1	1
Family A G protein-coupled receptor-like	POZ domain	1	1
Actin-crosslinking proteins	Actin-crosslinking proteins	1	1
WD40 repeat-like	Chromo domain-like	1	1
RNA-binding domain, RBD	ENTH/VHS domain	1	1
vWA-like	Cysteine-rich domain	1	1
SMAD/FHA domain	PDZ domain-like	1	1
Fibronectin type III	Family A G protein-coupled receptor-like	1	1
Mib/herc2 domain-like	Tudor/PWWP/MBT	1	1
DUSP-like	Ubiquitin-like	1	1
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
beta-beta-alpha zinc fingers	CCCH zinc finger	1	1
Cytochrome b5-like heme/steroid binding domain	Riboflavin synthase domain-like	1	1
Kazal-type serine protease inhibitors	C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase	1	1
Class II aaRS ABD-related	C-terminal domain of ProRS	1	1
Cysteine proteinases	Ankyrin repeat	1	1
ACT-like	Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	1	1
XRCC4, C-terminal oligomerization domain	DNase I-like	1	1
Regulator of G-protein signaling, RGS	Ubiquitin-like	1	1
Tudor/PWWP/MBT	Fibrinogen C-terminal domain-like	1	1
Actin-like ATPase domain	CV3147-like	1	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	1	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	1	1
Isocitrate/Isopropylmalate dehydrogenase-like	Porins	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
Family A G protein-coupled receptor-like	beta-lactamase/transpeptidase-like	1	1
Cupredoxins	Nucleotide cyclase	1	1
Fibrinogen C-terminal domain-like	SNARE-like	1	1
Terpenoid cyclases/Protein prenyltransferases	TIMP-like	1	1
RNA-binding domain, RBD	GYF domain	1	1
USP8 N-terminal domain-like	JAB1/MPN domain	1	1
Thioredoxin-like	DnaJ/Hsp40 cysteine-rich domain	1	1
Rudiment single hybrid motif	Formyltransferase	1	1
Calponin-homology domain, CH-domain	P-loop containing nucleoside triphosphate hydrolases	1	1
SPOC domain-like	SAP domain	1	1
Doublecortin (DC)	Ricin B-like lectins	1	1
Homeodomain-like	TNF-like	1	1
Kazal-type serine protease inhibitors	Concanavalin A-like lectins/glucanases	1	1
Trefoil	Concanavalin A-like lectins/glucanases	1	1
Spectrin repeat	GAS2 domain-like	1	1
Urease, gamma-subunit	Metallo-dependent hydrolases	1	1
N-terminal domain of adenylylcyclase associated protein, CAP	C-terminal domain of adenylylcyclase associated protein	1	1
Tudor/PWWP/MBT	RING/U-box	1	1
Chaperone J-domain	EPT/RTPC-like	1	1
Ubiquitin-like	TPR-like	1	1
Ypt/Rab-GAP domain of gyp1p	EF-hand	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	1	1
Thiolase-like	SCP-like	1	1
BSD domain-like	BSD domain-like	1	1
TPR-like	TSP type-3 repeat	1	1
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Family A G protein-coupled receptor-like	1	1
Dihydropteroate synthetase-like	Cobalamin (vitamin B12)-binding domain	1	1
(Phosphotyrosine protein) phosphatases II	DNA ligase/mRNA capping enzyme, catalytic domain	1	1
Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	1	1
Immunoglobulin	LDL receptor-like module	1	1
GST C-terminal domain-like	eEF1-gamma domain	1	1
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	1	1
HAD-like	alpha/beta-Hydrolases	1	1
Glycerol-3-phosphate (1)-acyltransferase	Glycerol-3-phosphate (1)-acyltransferase	1	1
Ubiquitin-like	SMAD/FHA domain	1	1
Cap-Gly domain	Protein kinase-like (PK-like)	1	1
GAT-like domain	Clathrin adaptor appendage domain	1	1
MAST3 pre-PK domain-like	Protein kinase-like (PK-like)	1	1
Tudor/PWWP/MBT	DNA repair protein MutS, domain III	1	1
Cytochrome c oxidase subunit II-like, transmembrane region	Cupredoxins	1	1
EF-hand	Eferin C-derminal domain-like	1	1
Nucleotidylyl transferase	MOP-like	1	1
CRAL/TRIO domain	GTPase activation domain, GAP	1	1
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain	Pyrimidine nucleoside phosphorylase C-terminal domain	1	1
FAD/NAD(P)-binding domain	EF-hand	1	1
BRCA2 helical domain	BRCA2 tower domain	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
Kelch motif	Fibronectin type III	1	1
EAL domain-like	HD-domain/PDEase-like	1	1
PH domain-like	I/LWEQ domain	1	1
Calcium-dependent phosphotriesterase	EGF/Laminin	1	1
Apolipoprotein A-I	NHL repeat	1	1
PGBD-like	PGBD-like	1	1
Acyl-CoA binding protein	ClpP/crotonase	1	1
Kazal-type serine protease inhibitors	Thyroglobulin type-1 domain	1	1
SMAD/FHA domain	BRCT domain	1	1
Indigoidine synthase A-like	Ribokinase-like	1	1
Kringle-like	Ricin B-like lectins	1	1
Ribosomal protein S5 domain 2-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
Hairpin loop containing domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Ubiquitin-like	PUA domain-like	1	1
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	1	1
Carboxypeptidase regulatory domain-like	Carboxypeptidase regulatory domain-like	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
TSP-1 type 1 repeat	PGBD-like	1	1
Ribonuclease H-like	CCCH zinc finger	1	1
Ferritin-like	Ferritin-like	1	1
WW domain	dsRNA-binding domain-like	1	1
YjgF-like	YjgF-like	1	1
RNA-binding domain, RBD	RNI-like	1	1
GST C-terminal domain-like	Class II aaRS and biotin synthetases	1	1
P-loop containing nucleoside triphosphate hydrolases	Toll/Interleukin receptor TIR domain	1	1
PUA domain-like	eIF1-like	1	1
TSP-1 type 1 repeat	Spermadhesin, CUB domain	1	1
SEA domain	Protein kinase-like (PK-like)	1	1