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Acting on the CH-OH group of donors

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <6>
+ 1:   Oxidoreductases [1] <23>(183|263) (202|169|83)
0:   Acting on the CH-OH group of donors [1.1] <8>(48|64) (54|45|27)
- 1:   With NAD(+) or NADP(+) as acceptor [1.1.1] <328>(41|57) (45|42|27)
- 1:   With oxygen as acceptor [1.1.3] <42>(4|4) (4|1|0)
- 1:   With other acceptors [1.1.99] <37>(3|3) (4|1|0)
- 1:   With a quinone or similar compound as acceptor [1.1.5] <9>(3|0) (4|1|0)
- 1:   With a cytochrome as acceptor [1.1.2] <8>(4|3) (6|2|0)
- 1:   With a disulfide as acceptor [1.1.4] <2>(0|0) (0|0|0)
- 1:   With other, known, acceptors [1.1.98] <2>(1|1) (1|0|0)
- 1:   With a copper protein as acceptor [1.1.9] <1>(0|0) (0|0|0)


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Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain0Direct
1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain0Direct
L-sulfolactate dehydrogenase-like0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
NAD(P)-linked oxidoreductase0Direct
Serine metabolism enzymes domain0Direct
ClpP/crotonase0Direct
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain0Direct
6-phosphogluconate dehydrogenase C-terminal domain-like0Direct
GroES-like0Direct
CBS-domain pair0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
LDH C-terminal domain-like0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
Dehydroquinate synthase-like0Direct
NAD(P)-binding Rossmann-fold domains0Direct
NAD-binding domain of HMG-CoA reductase0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Substrate-binding domain of HMG-CoA reductase0Direct
FAD-binding/transporter-associated domain-like0Direct
Quinoprotein alcohol dehydrogenase-like0.0000000003571Direct
FMT C-terminal domain-like0.00000002361Direct
Formyltransferase0.00000006079Direct
FMN-dependent nitroreductase-like0.00007071Direct
ACT-like0.0001632Direct
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.01533Inherited
EPT/RTPC-like0.01596Inherited
FAD-linked reductases, C-terminal domain0.01882Inherited
FabD/lysophospholipase-like0.1382Inherited
FAD-linked oxidases, C-terminal domain0.2332Inherited
ACP-like0.4378Inherited
Inosine monophosphate dehydrogenase (IMPDH)0.6132Inherited
EF-hand0.7901Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0.9449Inherited
Dihydrofolate reductase-like0.9597Inherited
Carbamate kinase-like1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
HisI-like1Inherited
Aldolase1Inherited
all-alpha NTP pyrophosphatases1Inherited
Bacterial luciferase-like1Inherited
Thiolase-like1Inherited
Cytidine deaminase-like1Inherited
Cytochrome P4501Inherited
alpha/beta-Hydrolases1Inherited
FAD/NAD(P)-binding domain1Inherited
ALDH-like1Inherited
FMN-linked oxidoreductases1Inherited


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Family

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SCOP term FDR (all) Annotation (direct or inherited)
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain0Direct
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain0Direct
Tyrosine-dependent oxidoreductases0Direct
L-sulfolactate dehydrogenase-like0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
NAD-binding domain of HMG-CoA reductase0Direct
Crotonase-like0Direct
HCDH C-domain-like0Direct
SerA intervening domain-like0Direct
UDP-glucose/GDP-mannose dehydrogenase dimerisation domain0Direct
Glycerol-3-phosphate dehydrogenase0Direct
Dihydrodipicolinate reductase-like0Direct
PdxA-like0Direct
CBS-domain pair0Direct
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain0Direct
Formate/glycerate dehydrogenases, substrate-binding domain0Direct
Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain0Direct
Ketopantoate reductase PanE0Direct
Aldo-keto reductases (NADP)0Direct
Shikimate kinase (AroK)0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
Malic enzyme N-domain0Direct
Quinoprotein alcohol dehydrogenase, C-terminal domain0Direct
RibD C-terminal domain-like0Direct
Mannitol 2-dehydrogenase0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Substrate-binding domain of HMG-CoA reductase0Direct
LDH N-terminal domain-like0Direct
Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI)0Direct
GMC oxidoreductases0Direct
Iron-containing alcohol dehydrogenase0Direct
Shikimate dehydrogenase-like0Direct
L-histidinol dehydrogenase HisD0Direct
1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain0Direct
Formate/glycerate dehydrogenases, NAD-domain0Direct
6-phosphogluconate dehydrogenase-like, N-terminal domain0Direct
Glucose 6-phosphate dehydrogenase-like0Direct
Dehydroquinate synthase, DHQS0.00000000000009317Direct
Deoxycytidylate deaminase-like0.00000000006066Direct
Quinoprotein alcohol dehydrogenase-like0.0000000003678Direct
Homoserine dehydrogenase-like0.000000003614Direct
Aspartokinase allosteric domain-like0.000000005282Direct
Acyl-carrier protein (ACP)0.000000006788Direct
Post formyltransferase domain0.00000002612Direct
Formyltransferase0.00000009675Direct
F420 dependent oxidoreductases0.000000424Direct
Thioesterase domain of polypeptide, polyketide and fatty acid synthases0.00000843Direct
NADH oxidase/flavin reductase0.00007396Direct
FAD-linked oxidases, N-terminal domain0.0006358Direct
FabD-like0.001653Inherited
Enolpyruvate transferase, EPT0.004542Inherited
Phosphotransacetylase0.005644Inherited
Aminoacid dehydrogenase-like, C-terminal domain0.04261Inherited
FAD-linked reductases, N-terminal domain0.06161Inherited
Class I aldolase0.3836Inherited
Inosine monophosphate dehydrogenase (IMPDH)0.4424Inherited
Thiolase-related0.8668Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0.9477Inherited
PyrH-like1Inherited
Cytochrome P4501Inherited
FMN-linked oxidoreductases1Inherited
HisI-like1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain0Direct
NAD(P)-linked oxidoreductase0Direct
NAD-binding domain of HMG-CoA reductase0Direct
Substrate-binding domain of HMG-CoA reductase0Direct
NAD(P)-binding Rossmann-fold domains0Direct
LDH C-terminal domain-like0Direct
1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
GroES-like0Direct
FAD-binding/transporter-associated domain-like0Direct
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain0Direct
Dehydroquinate synthase-like0Direct
CBS-domain pair0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
6-phosphogluconate dehydrogenase C-terminal domain-like0Direct
Methanol dehydrogenase subunit0Direct
ClpP/crotonase0Direct
L-sulfolactate dehydrogenase-like0Direct
Serine metabolism enzymes domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Quinoprotein alcohol dehydrogenase-like0.0000000002869Direct
FMT C-terminal domain-like0.00000001967Direct
Formyltransferase0.00000005079Direct
SCP-like0.00002956Direct
FMN-dependent nitroreductase-like0.00006033Direct
ACT-like0.0001414Direct
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.0135Inherited
EPT/RTPC-like0.01429Inherited
FAD-linked reductases, C-terminal domain0.01726Inherited
Thioesterase/thiol ester dehydrase-isomerase0.1119Inherited
FabD/lysophospholipase-like0.1258Inherited
Cytochrome c0.1727Inherited
FAD-linked oxidases, C-terminal domain0.215Inherited
ACP-like0.4083Inherited
Inosine monophosphate dehydrogenase (IMPDH)0.5796Inherited
EF-hand0.7437Inherited
Dihydrofolate reductase-like0.9083Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0.9135Inherited
4'-phosphopantetheinyl transferase1Inherited
Bacterial luciferase-like1Inherited
ALDH-like1Inherited
FAD/NAD(P)-binding domain1Inherited
Aldolase1Inherited
all-alpha NTP pyrophosphatases1Inherited
NagB/RpiA/CoA transferase-like1Inherited
Cytochrome P4501Inherited
FMN-linked oxidoreductases1Inherited
HisI-like1Inherited
Cytidine deaminase-like1Inherited
alpha/beta-Hydrolases1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Thiolase-like1Inherited
Carbamate kinase-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
101386,53720
  • 101386 - all-alpha NTP pyrophosphatases
  • 53720 - ALDH-like
  • 0Direct
    55205,52540
  • 55205 - EPT/RTPC-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51735,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    54637,55718
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 55718 - SCP-like
  • 0Direct
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    51569,53223
  • 51569 - Aldolase
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 0Direct
    52540,51569
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51569 - Aldolase
  • 0Direct
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    51735,53659
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 53659 - Isocitrate/Isopropylmalate dehydrogenase-like
  • 0Direct
    56176,56194
  • 56176 - FAD-binding/transporter-associated domain-like
  • 56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
  • 0Direct
    53927,53597
  • 53927 - Cytidine deaminase-like
  • 53597 - Dihydrofolate reductase-like
  • 0Direct
    48179,52096
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52096 - ClpP/crotonase
  • 0Direct
    52096,51735
  • 52096 - ClpP/crotonase
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    51735,55021
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55021 - ACT-like
  • 0Direct
    48179,54637
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    53720,56796
  • 53720 - ALDH-like
  • 56796 - Dehydroquinate synthase-like
  • 0Direct
    55347,55021
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 55021 - ACT-like
  • 0Direct
    48179,52413
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    51735,143548
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 143548 - Serine metabolism enzymes domain
  • 0Direct
    50998,46626
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 46626 - Cytochrome c
  • 0Direct
    51412,51412
  • 51412 - Inosine monophosphate dehydrogenase (IMPDH)
  • 51412 - Inosine monophosphate dehydrogenase (IMPDH)
  • 0Direct
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    55035,56542
  • 55035 - NAD-binding domain of HMG-CoA reductase
  • 56542 - Substrate-binding domain of HMG-CoA reductase
  • 0Direct
    55021,51735
  • 55021 - ACT-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    56796,55205
  • 56796 - Dehydroquinate synthase-like
  • 55205 - EPT/RTPC-like
  • 0Direct
    54631,51412
  • 54631 - CBS-domain pair
  • 51412 - Inosine monophosphate dehydrogenase (IMPDH)
  • 0Direct
    50486,51735
  • 50486 - FMT C-terminal domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    55347,69055
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
  • 0Direct
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.00000000000001871Direct
    143548,55021
  • 143548 - Serine metabolism enzymes domain
  • 55021 - ACT-like
  • 0.000000000004169Direct
    53633,55021
  • 53633 - Carbamate kinase-like
  • 55021 - ACT-like
  • 0.000000006398Direct
    53328,50486
  • 53328 - Formyltransferase
  • 50486 - FMT C-terminal domain-like
  • 0.000000009636Direct
    47336,53474
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 0.00000004075Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0.0000007809Direct
    51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.0002337Direct
    51735,51735
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.000527Direct
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.001651Inherited
    141734,101386
  • 141734 - HisI-like
  • 101386 - all-alpha NTP pyrophosphatases
  • 0.01249Inherited
    52151,55048
  • 52151 - FabD/lysophospholipase-like
  • 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase
  • 0.0135Inherited
    55021,55021
  • 55021 - ACT-like
  • 55021 - ACT-like
  • 0.08599Inherited
    56176,55103
  • 56176 - FAD-binding/transporter-associated domain-like
  • 55103 - FAD-linked oxidases, C-terminal domain
  • 0.215Inherited
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0.9154Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    56796,55205,52540
  • 56796 - Dehydroquinate synthase-like
  • 55205 - EPT/RTPC-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51735,55347,69055
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
  • 0Direct
    51735,54637,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    52283,51735,55021
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55021 - ACT-like
  • 0Direct
    52283,51735,143548
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 143548 - Serine metabolism enzymes domain
  • 0Direct
    53328,50486,51735
  • 53328 - Formyltransferase
  • 50486 - FMT C-terminal domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    51735,51735,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    54637,54637,55718
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 55718 - SCP-like
  • 0Direct
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    51569,53223,51735
  • 51569 - Aldolase
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    51735,55347,55021
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 55021 - ACT-like
  • 0Direct
    55205,52540,51569
  • 55205 - EPT/RTPC-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51569 - Aldolase
  • 0Direct
    52096,51735,48179
  • 52096 - ClpP/crotonase
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    141734,101386,53720
  • 141734 - HisI-like
  • 101386 - all-alpha NTP pyrophosphatases
  • 53720 - ALDH-like
  • 0Direct
    52540,51569,53223
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51569 - Aldolase
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 0Direct
    53223,51735,53659
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 53659 - Isocitrate/Isopropylmalate dehydrogenase-like
  • 0Direct
    55021,55021,51735
  • 55021 - ACT-like
  • 55021 - ACT-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    48179,48179,52096
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52096 - ClpP/crotonase
  • 0Direct
    51735,48179,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    51735,48179,52413
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain
  • 0Direct
    51735,143548,55021
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 143548 - Serine metabolism enzymes domain
  • 55021 - ACT-like
  • 0Direct
    55021,51735,55347
  • 55021 - ACT-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    51735,47336,53474
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 0.000000006139Direct
    53633,55021,55021
  • 53633 - Carbamate kinase-like
  • 55021 - ACT-like
  • 55021 - ACT-like
  • 0.000000006398Direct
    50129,51735,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.000004317Direct
    51735,51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.0001313Direct


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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