SUPERFAMILY 1.75 HMM library and genome assignments server

Acting on ester bonds

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <6>
+ 1:   Hydrolases [3] <13>(329|528) (368|389|207)
0:   Acting on ester bonds [3.1] <20>(124|170) (142|112|48)
- 1:   Carboxylic ester hydrolases [3.1.1] <91>(22|34) (27|13|0)
- 1:   Phosphoric monoester hydrolases [3.1.3] <90>(44|59) (55|43|12)
- 1:   Phosphoric diester hydrolases [3.1.4] <55>(25|23) (29|21|13)
- 1:   Thiolester hydrolases [3.1.2] <30>(12|14) (13|9|4)
- 1:   Sulfuric ester hydrolases [3.1.6] <18>(1|1) (1|0|0)
- 1:   Endoribonucleases producing 5'-phosphomonoesters [3.1.26] <14>(21|24) (22|16|14)
- 1:   Diphosphoric monoester hydrolases [3.1.7] <10>(4|2) (4|2|1)
- 1:   Endoribonucleases producing other than 5'-phosphom [3.1.27] <10>(5|5) (5|2|2)
- 1:   Endodeoxyribonucleases producing 5'-phosphomonoest [3.1.21] <7>(4|2) (6|1|0)
- 1:   Exodeoxyribonucleases producing 5'-phosphomonoeste [3.1.11] <6>(6|6) (7|1|0)
- 1:   Endodeoxyribonucleases producing other than 5'-pho [3.1.22] <5>(2|2) (2|0|0)
- 1:   Exoribonucleases producing 5'-phosphomonoesters [3.1.13] <5>(18|18) (19|18|13)
- 1:   Endoribonucleases active with either ribo- or deox [3.1.30] <2>(0|0) (1|0|0)
- 1:   Phosphoric triester hydrolases [3.1.8] <2>(1|1) (1|0|0)
- 1:   Site-specific endodeoxyribonucleases specific for [3.1.25] <2>(0|0) (0|0|0)
- 1:   Endoribonucleases active with either ribo- or deox [3.1.31] <1>(1|1) (1|0|0)
- 1:   Exonucleases active with either ribo- or deoxyribo [3.1.16] <1>(0|0) (0|0|0)
- 1:   Exonucleases active with either ribo- or deoxyribo [3.1.15] <1>(0|0) (0|0|0)
- 1:   Exoribonucleases producing 3'-phosphomonoesters [3.1.14] <1>(0|0) (0|0|0)
- 1:   Triphosphoric monoester hydrolases [3.1.5] <1>(1|1) (1|0|0)


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Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
cAMP-binding domain-like0Direct
PH domain-like0Direct
tRNA-intron endonuclease N-terminal domain-like0Direct
Carbohydrate phosphatase0Direct
Lipase/lipooxygenase domain (PLAT/LH2 domain)0Direct
EF-hand0Direct
FabD/lysophospholipase-like0Direct
Purple acid phosphatase, N-terminal domain0Direct
Somatomedin B domain0Direct
AlbA-like0Direct
DNA/RNA polymerases0Direct
DNA-binding domain of retroviral integrase0Direct
Retrovirus capsid dimerization domain-like0Direct
Methylesterase CheB, C-terminal domain0Direct
Toprim domain0Direct
Phospholipase C/P1 nuclease0Direct
C-terminal domain of PLC-beta0Direct
XseB-like0Direct
CheY-like0Direct
GAF domain-like0Direct
Outer membrane phospholipase A (OMPLA)0Direct
(Phosphotyrosine protein) phosphatases II0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
RNase A-like0Direct
Ribonuclease H-like0Direct
Plant invertase/pectin methylesterase inhibitor0Direct
Rof/RNase P subunit-like0Direct
Putative isomerase YbhE0Direct
Holliday junction resolvase RusA0Direct
Phosphoglycerate mutase-like0Direct
Rnp2-like0Direct
DNase I-like0Direct
Phospholipase A2, PLA20Direct
Ribosomal protein S5 domain 2-like0Direct
HAD-like0Direct
Phosphotyrosine protein phosphatases I0Direct
RNase III domain-like0Direct
Nitrous oxide reductase, N-terminal domain0Direct
His-Me finger endonucleases0Direct
Retroviral matrix proteins0Direct
Metallo-dependent phosphatases0Direct
SGNH hydrolase0Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0Direct
HD-domain/PDEase-like0Direct
Peptidyl-tRNA hydrolase domain-like0Direct
alpha/beta-Hydrolases0Direct
Peptidyl-tRNA hydrolase-like0Direct
Ribonuclease Rh-like0Direct
Retrovirus capsid protein, N-terminal core domain0Direct
Peptidyl-tRNA hydrolase II0Direct
L9 N-domain-like0Direct
Viral protein domain0Direct
SurE-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
ComB-like0Direct
Protein serine/threonine phosphatase 2C, C-terminal domain0Direct
Xylose isomerase-like0Direct
Metallo-hydrolase/oxidoreductase0Direct
PP2C-like0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
Microbial ribonucleases0Direct
Influenza hemagglutinin (stalk)0Direct
PLC-like phosphodiesterases0Direct
Retrovirus zinc finger-like domains0Direct
N-terminal Zn binding domain of HIV integrase0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
dsRNA-binding domain-like0Direct
Thermostable phytase (3-phytase)0Direct
Calcium-dependent phosphotriesterase0Direct
Phospholipase D/nuclease0Direct
WD40 repeat-like2.368e-16Direct
Fibronectin type III7.826e-15Direct
PHP domain-like3.611e-13Direct
Staphylococcal nuclease1.806e-10Direct
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain4.081e-10Direct
DEK C-terminal domain2.607e-09Direct
EAL domain-like5.04e-09Direct
LigT-like6.659e-09Direct
Alkaline phosphatase-like6.922e-09Direct
Second domain of FERM2.725e-08Direct
PX domain5.668e-07Direct
Integrin alpha N-terminal domain1.942e-06Direct
Saposin3.905e-06Direct
SH2 domain6.817e-06Direct
L domain-like7.56e-06Direct
Acid proteases8.641e-06Direct
CYTH-like phosphatases0.0001559Direct
Immunoglobulin0.0001702Direct
Pectin lyase-like0.0003098Direct
NTF2-like0.0006578Direct
HRDC-like0.001517Inherited
RNA-binding domain, RBD0.003436Inherited
Kelch motif0.007019Inherited
Ubiquitin-like0.0102Inherited
R3H domain0.03192Inherited
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.07992Inherited
Ankyrin repeat0.1213Inherited
DNA clamp0.1514Inherited
FYVE/PHD zinc finger0.2911Inherited
SH3-domain0.4052Inherited
Carbonic anhydrase0.4594Inherited
PYP-like sensor domain (PAS domain)0.4681Inherited
TPR-like0.5472Inherited
SAM/Pointed domain0.558Inherited
ACP-like0.6299Inherited
AraD/HMP-PK domain-like0.997Inherited
Restriction endonuclease-like1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Macro domain-like1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
ClpP/crotonase1Inherited
GroES-like1Inherited
NagB/RpiA/CoA transferase-like1Inherited
Cysteine proteinases1Inherited
Thiolase-like1Inherited
DNA ligase/mRNA capping enzyme, catalytic domain1Inherited
PDZ domain-like1Inherited
ACT-like1Inherited
TGS-like1Inherited
Nucleotidyltransferase1Inherited
Nucleic acid-binding proteins1Inherited
dUTPase-like1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Concanavalin A-like lectins/glucanases1Inherited


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Family

(show details)
SCOP term FDR (all) Annotation (direct or inherited)
Mammalian PLC0Direct
4HBT-like0Direct
DnaQ-like 3'-5' exonuclease0Direct
RuvC resolvase0Direct
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain0Direct
Pyrimidine 5'-nucleotidase (UMPH-1)0Direct
Vertebrate phospholipase A20Direct
Type 2 phosphatidic acid phosphatase, PAP20Direct
Thioesterases0Direct
Ribonuclease H0Direct
GlpX-like bacterial fructose-1,6-bisphosphatase0Direct
Pancreatic lipase, N-terminal domain0Direct
Phosphoserine phosphatase0Direct
Pectin methylesterase0Direct
Retrovirus zinc finger-like domains0Direct
RNase P subunit p29-like0Direct
N-terminal domain of RNase HI0Direct
Glyoxalase II (hydroxyacylglutathione hydrolase)0Direct
YfcE-like0Direct
Retrovirus capsid protein C-terminal domain0Direct
Patatin0Direct
Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF10Direct
Staphylococcal nuclease0Direct
EAL domain0Direct
Influenza hemagglutinin (stalk)0Direct
GpdQ-like0Direct
Rpp14/Pop5-like0Direct
2',3'-cyclic nucleotide 3'-phosphodiesterase, catalytic domain0Direct
HD domain0Direct
Nuclease0Direct
RNB domain-like0Direct
CAF1-like ribonuclease0Direct
Higher-molecular-weight phosphotyrosine protein phosphatases0Direct
Arylsulfatase0Direct
Protein serine/threonine phosphatase0Direct
Histidinol phosphatase-like0Direct
N-terminal Zn binding domain of HIV integrase0Direct
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0Direct
RNase III catalytic domain-like0Direct
Biotin biosynthesis protein BioH0Direct
Acetylcholinesterase-like0Direct
MtnX-like0Direct
Integrin alpha N-terminal domain0Direct
Myotubularin-like phosphatases0Direct
beta-Phosphoglucomutase-like0Direct
Enolase-phosphatase E10Direct
Methylesterase CheB, C-terminal domain0Direct
Immunodeficiency virus matrix proteins0Direct
Fungal ribonucleases0Direct
Purple acid phosphatase, N-terminal domain0Direct
Somatomedin B domain0Direct
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain0Direct
Dienelactone hydrolase0Direct
cAMP-binding domain0Direct
Peptidyl-tRNA hydrolase II0Direct
HTLV-II matrix protein0Direct
Outer membrane phospholipase A (OMPLA)0Direct
PDEase0Direct
Toprim domain0Direct
Glycerophosphoryl diester phosphodiesterase0Direct
Fungal lipases0Direct
PLC-like (P variant)0Direct
GAF domain0Direct
Ribonuclease A-like0Direct
SurE-like0Direct
Low-molecular-weight phosphotyrosine protein phosphatases0Direct
mRNA triphosphatase CET10Direct
EF-hand modules in multidomain proteins0Direct
Lysophospholipase0Direct
Protein serine/threonine phosphatase 2C, C-terminal domain0Direct
Holliday junction resolvase RusA0Direct
ComB-like0Direct
Hypothetical esterase YJL068C0Direct
5' nucleotidase-like0Direct
Plant invertase/pectin methylesterase inhibitor0Direct
PP2C-like0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Retroviral protease (retropepsin)0Direct
Predicted hydrolases Cof0Direct
C-terminal domain of PLC-beta0Direct
Alkaline phosphatase0Direct
Reverse transcriptase0Direct
Cutinase-like0Direct
Bacterial lipase0Direct
SGL-like0Direct
CheY-related0Direct
XseB-like0Direct
Nitrous oxide reductase, N-terminal domain0Direct
RNase P protein0Direct
Dual specificity phosphatase-like0Direct
Leucine rich effector protein YopM0Direct
Purple acid phosphatase-like0Direct
Histidine acid phosphatase0Direct
Endonuclease IV0Direct
Colipase-binding domain0Direct
Class B acid phosphatase, AphA0Direct
tRNA-intron endonuclease N-terminal domain-like0Direct
Peptidyl-tRNA hydrolase-like0Direct
NLI interacting factor-like phosphatase0Direct
DNA/RNA non-specific endonuclease0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Sphingomyelin phosphodiesterase-like0Direct
RNase D C-terminal domains0Direct
Retroviral integrase, catalytic domain0Direct
Retrovirus capsid protein, N-terminal core domain0Direct
Ribonuclease Rh-like0Direct
Peptidyl-tRNA hydrolase domain0Direct
Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF10Direct
Exodeoxyribonuclease V beta chain (RecC), C-terminal domain0Direct
GRAM domain0Direct
Alpha-toxin, C-terminal domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Insect phospholipase A20Direct
Cell cycle control phosphatase, catalytic domain0Direct
DNA-binding domain of retroviral integrase0Direct
Gastric lipase0Direct
RNase P subunit p300Direct
Phospholipase C0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
RNase Z-like0Direct
Trehalose-phosphatase3.476e-16Direct
Fibronectin type III1.381e-15Direct
Carboxylesterase5.46e-14Direct
Cold shock DNA-binding domain-like1.445e-12Direct
Pleckstrin-homology domain (PH domain)1.836e-12Direct
DNase I-like4.773e-12Direct
Third domain of FERM7.268e-12Direct
Acetylhydrolase1.176e-11Direct
5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain1.597e-10Direct
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain1.597e-10Direct
First domain of FERM8.39e-10Direct
Second domain of FERM9.819e-09Direct
Acyl-carrier protein (ACP)5.434e-08Direct
RelA/SpoT domain1.07e-07Direct
DEK C-terminal domain3.54e-07Direct
FYVE, a phosphatidylinositol-3-phosphate binding domain3.973e-07Direct
I set domains6.059e-07Direct
Imidazole glycerol phosphate dehydratase1.708e-06Direct
Probable phosphatase YrbI1.866e-06Direct
PDZ domain2.69e-06Direct
SH2 domain3.398e-06Direct
Thioesterase domain of polypeptide, polyketide and fatty acid synthases3.809e-06Direct
Canonical RBD6.192e-06Direct
CoA transferase alpha subunit-like7.28e-06Direct
PX domain1.78e-05Direct
MaoC-like0.0004252Direct
FabD-like0.0005874Direct
NagD-like0.0006084Direct
MAM domain0.007596Inherited
R3H domain0.02304Inherited
Macro domain0.03058Inherited
Tetratricopeptide repeat (TPR)0.06133Inherited
Ubiquitin-related0.06747Inherited
Ankyrin repeat0.0886Inherited
Cofactor-dependent phosphoglycerate mutase0.08912Inherited
SAM (sterile alpha motif) domain0.2857Inherited
SH3-domain0.3399Inherited
Carbonic anhydrase0.3985Inherited
DNA polymerase I0.472Inherited
Crotonase-like0.6802Inherited
Carbon-carbon bond hydrolase0.8232Inherited
AraD-like aldolase/epimerase0.895Inherited
Tyrosine-dependent oxidoreductases1Inherited
Thiolase-related1Inherited
dUTPase-like1Inherited
Tandem AAA-ATPase domain1Inherited
Alcohol dehydrogenase-like, N-terminal domain1Inherited
Alcohol dehydrogenase-like, C-terminal domain1Inherited
Exodeoxyribonuclease V beta chain (RecB), C-terminal domain1Inherited
NagB-like1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Plant invertase/pectin methylesterase inhibitor0Direct
DNase I-like0Direct
Outer membrane phospholipase A (OMPLA)0Direct
PH domain-like0Direct
N-terminal Zn binding domain of HIV integrase0Direct
PP2C-like0Direct
Voltage-gated potassium channels0Direct
Lipase/lipooxygenase domain (PLAT/LH2 domain)0Direct
Ribonuclease H-like0Direct
Influenza hemagglutinin (stalk)0Direct
tRNA-intron endonuclease N-terminal domain-like0Direct
EF-hand0Direct
L9 N-domain-like0Direct
Retroviral matrix proteins0Direct
Phosphoglycerate mutase-like0Direct
Retrovirus zinc finger-like domains0Direct
AlbA-like0Direct
Bacterial GAP domain0Direct
Carbohydrate phosphatase0Direct
Holliday junction resolvase RusA0Direct
CRAL/TRIO N-terminal domain0Direct
Calcium-dependent phosphotriesterase0Direct
Rof/RNase P subunit-like0Direct
Phospholipase C/P1 nuclease0Direct
HD-domain/PDEase-like0Direct
Putative isomerase YbhE0Direct
HAD-like0Direct
Protein serine/threonine phosphatase 2C, C-terminal domain0Direct
PLC-like phosphodiesterases0Direct
His-Me finger endonucleases0Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0Direct
RNase A-like0Direct
DNA-binding domain of retroviral integrase0Direct
Toprim domain0Direct
Metallo-hydrolase/oxidoreductase0Direct
Rnp2-like0Direct
Metallo-dependent phosphatases0Direct
alpha/beta-Hydrolases0Direct
RNase III domain-like0Direct
(Phosphotyrosine protein) phosphatases II0Direct
Viral protein domain0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
Rhodanese/Cell cycle control phosphatase0Direct
SGNH hydrolase0Direct
Peptidyl-tRNA hydrolase domain-like0Direct
Ribonuclease Rh-like0Direct
FabD/lysophospholipase-like0Direct
Retrovirus capsid protein, N-terminal core domain0Direct
Peptidyl-tRNA hydrolase-like0Direct
dsRNA-binding domain-like0Direct
Purple acid phosphatase, N-terminal domain0Direct
Microbial ribonucleases0Direct
Thermostable phytase (3-phytase)0Direct
GAF domain-like0Direct
Xylose isomerase-like0Direct
Somatomedin B domain0Direct
XseB-like0Direct
ComB-like0Direct
Peptidyl-tRNA hydrolase II0Direct
Phosphotyrosine protein phosphatases I0Direct
C-terminal domain of PLC-beta0Direct
Retrovirus capsid dimerization domain-like0Direct
Acid phosphatase/Vanadium-dependent haloperoxidase0Direct
Ribosomal protein S5 domain 2-like0Direct
Phospholipase A2, PLA20Direct
Nitrous oxide reductase, N-terminal domain0Direct
DNA/RNA polymerases0Direct
Phospholipase D/nuclease0Direct
cAMP-binding domain-like0Direct
SurE-like0Direct
Methylesterase CheB, C-terminal domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
CheY-like0Direct
WD40 repeat-like1.756e-16Direct
Fibronectin type III6.742e-15Direct
PHP domain-like2.915e-13Direct
Staphylococcal nuclease1.439e-10Direct
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain3.387e-10Direct
DEK C-terminal domain2.098e-09Direct
EAL domain-like4.062e-09Direct
LigT-like5.519e-09Direct
Alkaline phosphatase-like5.968e-09Direct
Second domain of FERM2.232e-08Direct
PX domain4.686e-07Direct
CYTH-like phosphatases7.193e-07Direct
Integrin alpha N-terminal domain1.604e-06Direct
Saposin3.294e-06Direct
SH2 domain5.807e-06Direct
L domain-like6.477e-06Direct
Acid proteases8.081e-06Direct
Ras GEF7.977e-05Direct
Immunoglobulin0.0001477Direct
Chaperone J-domain0.0002247Direct
GTPase activation domain, GAP0.0002247Direct
Pectin lyase-like0.0002904Direct
NTF2-like0.000569Direct
HRDC-like0.001348Inherited
CRAL/TRIO domain0.00159Inherited
RNA-binding domain, RBD0.003049Inherited
Kelch motif0.00616Inherited
Ubiquitin-like0.009215Inherited
Non-globular alpha+beta subunits of globular proteins0.02412Inherited
R3H domain0.02864Inherited
SMAD/FHA domain0.03304Inherited
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.07215Inherited
PIN domain-like0.08088Inherited
DNA clamp0.138Inherited
Ankyrin repeat0.1406Inherited
L30e-like0.1678Inherited
Methylated DNA-protein cysteine methyltransferase, C-terminal domain0.2191Inherited
Bet v1-like0.2351Inherited
Autotransporter0.2452Inherited
Quinoprotein alcohol dehydrogenase-like0.2636Inherited
FYVE/PHD zinc finger0.2701Inherited
SH3-domain0.3777Inherited
Starch-binding domain-like0.4012Inherited
Carbonic anhydrase0.4295Inherited
PYP-like sensor domain (PAS domain)0.4383Inherited
TPR-like0.5135Inherited
SAM/Pointed domain0.5236Inherited
ACP-like0.5919Inherited
AraD/HMP-PK domain-like0.9434Inherited
dUTPase-like1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Glutaminase/Asparaginase1Inherited
DNA ligase/mRNA capping enzyme, catalytic domain1Inherited
GroES-like1Inherited
NagB/RpiA/CoA transferase-like1Inherited
UDP-Glycosyltransferase/glycogen phosphorylase1Inherited
Nucleic acid-binding proteins1Inherited
Restriction endonuclease-like1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
ACT-like1Inherited
TGS-like1Inherited
PDZ domain-like1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Concanavalin A-like lectins/glucanases1Inherited
ClpP/crotonase1Inherited
Nucleotidyltransferase1Inherited
Thiolase-like1Inherited
Macro domain-like1Inherited
Cysteine proteinases1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
82708,53098
  • 82708 - R3H domain
  • 53098 - Ribonuclease H-like
  • 0Direct
    47353,57756
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    53098,53098
  • 53098 - Ribonuclease H-like
  • 53098 - Ribonuclease H-like
  • 0Direct
    56219,54928
  • 56219 - DNase I-like
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    56784,54427
  • 56784 - HAD-like
  • 54427 - NTF2-like
  • 0Direct
    50156,52799
  • 50156 - PDZ domain-like
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    46938,52087
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 0Direct
    57756,50630
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 0Direct
    49562,52151
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    51283,46919
  • 51283 - dUTPase-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0Direct
    48452,56300
  • 48452 - TPR-like
  • 56300 - Metallo-dependent phosphatases
  • 0Direct
    54001,53098
  • 54001 - Cysteine proteinases
  • 53098 - Ribonuclease H-like
  • 0Direct
    52540,55144
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 55144 - LigT-like
  • 0Direct
    54637,55961
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 55961 - Bet v1-like
  • 0Direct
    81324,52799
  • 81324 - Voltage-gated potassium channels
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    48537,49723
  • 48537 - Phospholipase C/P1 nuclease
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    56784,54211
  • 56784 - HAD-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    81606,81601
  • 81606 - PP2C-like
  • 81601 - Protein serine/threonine phosphatase 2C, C-terminal domain
  • 0Direct
    52540,53254
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 53254 - Phosphoglycerate mutase-like
  • 0Direct
    69065,54768
  • 69065 - RNase III domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    101908,56219
  • 101908 - Putative isomerase YbhE
  • 56219 - DNase I-like
  • 0Direct
    52266,49818
  • 52266 - SGNH hydrolase
  • 49818 - Viral protein domain
  • 0Direct
    53098,54928
  • 53098 - Ribonuclease H-like
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    49562,56024
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 56024 - Phospholipase D/nuclease
  • 0Direct
    47943,47353
  • 47943 - Retrovirus capsid protein, N-terminal core domain
  • 47353 - Retrovirus capsid dimerization domain-like
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    56784,56784
  • 56784 - HAD-like
  • 56784 - HAD-like
  • 0Direct
    47233,52799
  • 47233 - Bacterial GAP domain
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    53098,51283
  • 53098 - Ribonuclease H-like
  • 51283 - dUTPase-like
  • 0Direct
    55658,53098
  • 55658 - L9 N-domain-like
  • 53098 - Ribonuclease H-like
  • 0Direct
    47819,47819
  • 47819 - HRDC-like
  • 47819 - HRDC-like
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    46919,53098
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 0Direct
    49363,56300
  • 49363 - Purple acid phosphatase, N-terminal domain
  • 56300 - Metallo-dependent phosphatases
  • 0Direct
    49452,52799
  • 49452 - Starch-binding domain-like
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    51695,51695
  • 51695 - PLC-like phosphodiesterases
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    53098,46919
  • 53098 - Ribonuclease H-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0Direct
    49899,48726
  • 49899 - Concanavalin A-like lectins/glucanases
  • 48726 - Immunoglobulin
  • 0Direct
    52058,56219
  • 52058 - L domain-like
  • 56219 - DNase I-like
  • 0Direct
    52799,52799
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    52799,56091
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    53639,56784
  • 53639 - AraD/HMP-PK domain-like
  • 56784 - HAD-like
  • 0Direct
    54637,52151
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    51069,49265
  • 51069 - Carbonic anhydrase
  • 49265 - Fibronectin type III
  • 0Direct
    101148,51126
  • 101148 - Plant invertase/pectin methylesterase inhibitor
  • 51126 - Pectin lyase-like
  • 0Direct
    55267,53032
  • 55267 - tRNA-intron endonuclease N-terminal domain-like
  • 53032 - tRNA-intron endonuclease catalytic domain-like
  • 0Direct
    90188,90188
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 0Direct
    52151,52151
  • 52151 - FabD/lysophospholipase-like
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    52172,52738
  • 52172 - CheY-like
  • 52738 - Methylesterase CheB, C-terminal domain
  • 0Direct
    50044,51695
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    53032,55267
  • 53032 - tRNA-intron endonuclease catalytic domain-like
  • 55267 - tRNA-intron endonuclease N-terminal domain-like
  • 0Direct
    50974,50974
  • 50974 - Nitrous oxide reductase, N-terminal domain
  • 50974 - Nitrous oxide reductase, N-terminal domain
  • 0Direct
    56672,53098
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 0Direct
    50630,56672
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52266,103515
  • 52266 - SGNH hydrolase
  • 103515 - Autotransporter
  • 0Direct
    52821,52799
  • 52821 - Rhodanese/Cell cycle control phosphatase
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    52087,52799
  • 52087 - CRAL/TRIO domain
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    53098,50122
  • 53098 - Ribonuclease H-like
  • 50122 - DNA-binding domain of retroviral integrase
  • 0Direct
    53649,54060
  • 53649 - Alkaline phosphatase-like
  • 54060 - His-Me finger endonucleases
  • 0Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    69065,69065
  • 69065 - RNase III domain-like
  • 69065 - RNase III domain-like
  • 0Direct
    55550,52799
  • 55550 - SH2 domain
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    56300,47473
  • 56300 - Metallo-dependent phosphatases
  • 47473 - EF-hand
  • 0Direct
    56300,56300
  • 56300 - Metallo-dependent phosphatases
  • 56300 - Metallo-dependent phosphatases
  • 0Direct
    56784,52540
  • 56784 - HAD-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    47836,47943
  • 47836 - Retroviral matrix proteins
  • 47943 - Retrovirus capsid protein, N-terminal core domain
  • 0Direct
    53098,47819
  • 53098 - Ribonuclease H-like
  • 47819 - HRDC-like
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    50729,56024
  • 50729 - PH domain-like
  • 56024 - Phospholipase D/nuclease
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    48403,52151
  • 48403 - Ankyrin repeat
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    54236,56784
  • 54236 - Ubiquitin-like
  • 56784 - HAD-like
  • 0Direct
    50729,52799
  • 50729 - PH domain-like
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    49562,54236
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 54236 - Ubiquitin-like
  • 0Direct
    55154,56091
  • 55154 - CYTH-like phosphatases
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    109715,52799
  • 109715 - DEK C-terminal domain
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    56568,47233
  • 56568 - Non-globular alpha+beta subunits of globular proteins
  • 47233 - Bacterial GAP domain
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 2.433e-15Direct
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 5.366e-15Direct
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 3.954e-12Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 1.061e-11Direct
    64268,50729
  • 64268 - PX domain
  • 50729 - PH domain-like
  • 1.548e-11Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 2.64e-10Direct
    56300,55816
  • 56300 - Metallo-dependent phosphatases
  • 55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain
  • 3.387e-10Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 9.723e-10Direct
    53474,53474
  • 53474 - alpha/beta-Hydrolases
  • 53474 - alpha/beta-Hydrolases
  • 1.537e-09Direct
    109604,81301
  • 109604 - HD-domain/PDEase-like
  • 81301 - Nucleotidyltransferase
  • 6.187e-08Direct
    100950,100950
  • 100950 - NagB/RpiA/CoA transferase-like
  • 100950 - NagB/RpiA/CoA transferase-like
  • 6.235e-08Direct
    56024,56024
  • 56024 - Phospholipase D/nuclease
  • 56024 - Phospholipase D/nuclease
  • 2.495e-07Direct
    47336,53474
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 4.283e-07Direct
    81301,81271
  • 81301 - Nucleotidyltransferase
  • 81271 - TGS-like
  • 2.717e-06Direct
    54211,54211
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 4.075e-06Direct
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 1.71e-05Direct
    53335,52949
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 52949 - Macro domain-like
  • 4.213e-05Direct
    53474,53335
  • 53474 - alpha/beta-Hydrolases
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 7.977e-05Direct
    51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.001882Inherited
    51735,51735
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.005683Inherited
    53774,48403
  • 53774 - Glutaminase/Asparaginase
  • 48403 - Ankyrin repeat
  • 0.006896Inherited
    53756,56784
  • 53756 - UDP-Glycosyltransferase/glycogen phosphorylase
  • 56784 - HAD-like
  • 0.008587Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.01532Inherited
    52151,55048
  • 52151 - FabD/lysophospholipase-like
  • 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase
  • 0.07215Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.07747Inherited
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.2839Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 1Inherited
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,56024,56024
  • 50729 - PH domain-like
  • 56024 - Phospholipase D/nuclease
  • 56024 - Phospholipase D/nuclease
  • 0Direct
    46938,52087,52799
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    55550,55550,50044
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    53098,51283,46919
  • 53098 - Ribonuclease H-like
  • 51283 - dUTPase-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    56672,53098,51283
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 51283 - dUTPase-like
  • 0Direct
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    47473,51695,49562
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    55550,55550,52799
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    53098,46919,53098
  • 53098 - Ribonuclease H-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 0Direct
    50044,51695,49562
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    57756,50630,56672
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    47836,47943,47353
  • 47836 - Retroviral matrix proteins
  • 47943 - Retrovirus capsid protein, N-terminal core domain
  • 47353 - Retrovirus capsid dimerization domain-like
  • 0Direct
    49899,48726,49265
  • 49899 - Concanavalin A-like lectins/glucanases
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0Direct
    55781,55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    47943,47353,57756
  • 47943 - Retrovirus capsid protein, N-terminal core domain
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    56024,56024,56024
  • 56024 - Phospholipase D/nuclease
  • 56024 - Phospholipase D/nuclease
  • 56024 - Phospholipase D/nuclease
  • 0Direct
    56672,53098,46919
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0Direct
    46919,53098,50122
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 50122 - DNA-binding domain of retroviral integrase
  • 0Direct
    56672,53098,50122
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 50122 - DNA-binding domain of retroviral integrase
  • 0Direct
    90188,53649,54060
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 54060 - His-Me finger endonucleases
  • 0Direct
    56568,47233,52799
  • 56568 - Non-globular alpha+beta subunits of globular proteins
  • 47233 - Bacterial GAP domain
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    55267,53032,55267
  • 55267 - tRNA-intron endonuclease N-terminal domain-like
  • 53032 - tRNA-intron endonuclease catalytic domain-like
  • 55267 - tRNA-intron endonuclease N-terminal domain-like
  • 0Direct
    56784,54211,54211
  • 56784 - HAD-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    69065,69065,54768
  • 69065 - RNase III domain-like
  • 69065 - RNase III domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    47353,57756,50630
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 0Direct
    81324,52799,49562
  • 81324 - Voltage-gated potassium channels
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    53098,47819,47819
  • 53098 - Ribonuclease H-like
  • 47819 - HRDC-like
  • 47819 - HRDC-like
  • 0Direct
    55550,50044,51695
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    64268,50729,56024
  • 64268 - PX domain
  • 50729 - PH domain-like
  • 56024 - Phospholipase D/nuclease
  • 0Direct
    51283,46919,53098
  • 51283 - dUTPase-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 0Direct
    52799,56091,50249
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    50630,56672,53098
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 0Direct
    56672,53098,53098
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 53098 - Ribonuclease H-like
  • 0Direct
    54637,54637,55961
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 55961 - Bet v1-like
  • 0Direct
    49562,54236,54236
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0Direct
    82708,53098,54928
  • 82708 - R3H domain
  • 53098 - Ribonuclease H-like
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    53032,55267,53032
  • 53032 - tRNA-intron endonuclease catalytic domain-like
  • 55267 - tRNA-intron endonuclease N-terminal domain-like
  • 53032 - tRNA-intron endonuclease catalytic domain-like
  • 0Direct
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 1.914e-15Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 1.061e-11Direct
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 3.465e-08Direct
    51735,47336,53474
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 6.565e-08Direct
    109604,81301,81271
  • 109604 - HD-domain/PDEase-like
  • 81301 - Nucleotidyltransferase
  • 81271 - TGS-like
  • 2.717e-06Direct
    50129,51735,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 4.126e-05Direct
    51735,51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.001091Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.01003Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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