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Carbon-carbon lyases

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <6>
+ 1:   Lyases [4] <7>(139|176) (158|94|34)
0:   Carbon-carbon lyases [4.1] <4>(54|67) (59|30|8)
- 1:   Carboxy-lyases [4.1.1] <95>(40|48) (44|20|5)
- 1:   Aldehyde-lyases [4.1.2] <54>(10|12) (11|5|2)
- 1:   Oxo-acid-lyases [4.1.3] <41>(9|10) (10|6|2)
- 1:   Other carbon-carbon lyases [4.1.99] <19>(5|5) (5|2|0)


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Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
PLP-binding barrel0Direct
RuBisCO, large subunit, small (N-terminal) domain0Direct
RuBisCo, C-terminal domain0Direct
Chorismate lyase-like0Direct
Cryptochrome/photolyase FAD-binding domain0Direct
Aldolase0Direct
AF0104/ALDC/Ptd012-like0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0Direct
Alanine racemase C-terminal domain-like0Direct
PEP carboxykinase N-terminal domain0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
RibA-like0Direct
S-adenosylmethionine decarboxylase0Direct
Acetoacetate decarboxylase-like0Direct
YrdC/RibB0Direct
UROD/MetE-like0Direct
UraD-Like0Direct
ADC-like0Direct
Ornithine decarboxylase C-terminal domain0Direct
post-HMGL domain-like0Direct
Pyruvoyl-dependent histidine and arginine decarboxylases0Direct
PEP carboxykinase-like0Direct
RuBisCO, small subunit0Direct
CoaB-like0Direct
Cryptochrome/photolyase, N-terminal domain0Direct
Ribulose-phoshate binding barrel0Direct
ADC synthase0Direct
DHS-like NAD/FAD-binding domain9.368e-16Direct
PLP-dependent transferases0.0000000001997Direct
Tautomerase/MIF0.00000001825Direct
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK0.00005088Direct
Thiamin diphosphate-binding fold (THDP-binding)0.0002189Direct
Glutamine synthetase, N-terminal domain0.003964Inherited
D-aminoacid aminotransferase-like PLP-dependent enzymes0.007714Inherited
Rudiment single hybrid motif0.04966Inherited
Tetrahydrobiopterin biosynthesis enzymes-like0.05614Inherited
CoA-dependent acyltransferases0.1082Inherited
Class I glutamine amidotransferase-like0.3431Inherited
Glutamine synthetase/guanido kinase0.4168Inherited
FAH1Inherited
SAICAR synthase-like1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
ClpP/crotonase1Inherited
AraD/HMP-PK domain-like1Inherited
GHMP Kinase, C-terminal domain1Inherited
RmlC-like cupins1Inherited
Ribosomal protein S5 domain 2-like1Inherited
Isocitrate/Isopropylmalate dehydrogenase-like1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
FAD/NAD(P)-binding domain1Inherited
FAD-linked reductases, C-terminal domain1Inherited
PreATP-grasp domain1Inherited
Metallo-dependent hydrolases1Inherited


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Family

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SCOP term FDR (all) Annotation (direct or inherited)
Pyridoxal-dependent decarboxylase0Direct
Arginine decarboxylase0Direct
Pyruvate oxidase and decarboxylase PP module0Direct
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB0Direct
Uroporphyrinogen decarboxylase, UROD0Direct
PEP carboxykinase C-terminal domain0Direct
Decarboxylase0Direct
S-adenosylmethionine decarboxylase0Direct
ADC synthase0Direct
HpcH/HpaI aldolase0Direct
Chorismate lyase0Direct
Alpha-acetolactate decarboxylase-like0Direct
Mevalonate 5-diphosphate decarboxylase0Direct
Beta-eliminating lyases0Direct
Ornithine decarboxylase major domain0Direct
RuBisCO, small subunit0Direct
DHN aldolase/epimerase0Direct
Pyruvoyl dependent aspartate decarboxylase, ADC0Direct
Ribulose 1,5-bisphosphate carboxylase-oxygenase0Direct
Acetoacetate decarboxylase-like0Direct
Cryptochrome/photolyase FAD-binding domain0Direct
HMGL-like0Direct
Histidine decarboxylase0Direct
PEP carboxykinase N-terminal domain0Direct
DmpG/LeuA communication domain-like0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
Bacterial S-adenosylmethionine decarboxylase0Direct
Phosphoenolpyruvate mutase/Isocitrate lyase-like0Direct
Alanine racemase-like, N-terminal domain0Direct
Cryptochrome/photolyase, N-terminal domain0Direct
RibA-like0Direct
Formaldehyde-activating enzyme, FAE0Direct
Phosphoenolpyruvate carboxylase0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0Direct
UraD-like0Direct
RuBisCo, large subunit, C-terminal domain0Direct
Eukaryotic ODC-like0Direct
Ornithine decarboxylase C-terminal domain0Direct
Class II FBP aldolase0Direct
Pyruvate oxidase and decarboxylase, middle domain0Direct
PP1699/LP2961-like0Direct
CoaB-like1.746e-16Direct
Tryptophan biosynthesis enzymes0.000000000001624Direct
Pyruvate oxidase and decarboxylase Pyr module0.00000000003283Direct
Class I aldolase0.000000005623Direct
MIF-related0.00000001371Direct
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK0.00005763Direct
Glutamine synthetase, N-terminal domain0.004793Inherited
Branched-chain alpha-keto acid dehydrogenase Pyr module0.005583Inherited
CAT-like0.006406Inherited
Glutamine synthetase catalytic domain0.006882Inherited
Branched-chain alpha-keto acid dehydrogenase PP module0.01627Inherited
D-aminoacid aminotransferase-like PLP-dependent enzymes0.02756Inherited
BC C-terminal domain-like0.05958Inherited
GMC oxidoreductases0.09426Inherited
Class I glutamine amidotransferases (GAT)0.1627Inherited
BC ATP-binding domain-like0.8884Inherited
BC N-terminal domain-like0.9427Inherited
Tyrosine-dependent oxidoreductases1Inherited
FAH1Inherited
Crotonase-like1Inherited
GHMP Kinase, N-terminal domain1Inherited
AAT-like1Inherited
SAICAR synthase1Inherited
Dimeric isocitrate & isopropylmalate dehydrogenases1Inherited
FAD-linked reductases, N-terminal domain1Inherited
AraD-like aldolase/epimerase1Inherited


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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
UraD-Like0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0Direct
AF0104/ALDC/Ptd012-like0Direct
YrdC/RibB0Direct
ADC-like0Direct
Cryptochrome/photolyase FAD-binding domain0Direct
post-HMGL domain-like0Direct
Aldolase0Direct
Cryptochrome/photolyase, N-terminal domain0Direct
PEP carboxykinase-like0Direct
UROD/MetE-like0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
Chorismate lyase-like0Direct
RuBisCo, C-terminal domain0Direct
PEP carboxykinase N-terminal domain0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
RibA-like0Direct
Acetoacetate decarboxylase-like0Direct
S-adenosylmethionine decarboxylase0Direct
Ornithine decarboxylase C-terminal domain0Direct
Alanine racemase C-terminal domain-like0Direct
PLP-binding barrel0Direct
RuBisCO, small subunit0Direct
CoaB-like0Direct
ADC synthase0Direct
Pyruvoyl-dependent histidine and arginine decarboxylases0Direct
Ribulose-phoshate binding barrel0Direct
RuBisCO, large subunit, small (N-terminal) domain0Direct
DHS-like NAD/FAD-binding domain6.987e-16Direct
PLP-dependent transferases0.000000000127Direct
Tautomerase/MIF0.00000001422Direct
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK0.00004161Direct
Thiamin diphosphate-binding fold (THDP-binding)0.0001749Direct
Glutamine synthetase, N-terminal domain0.003342Inherited
D-aminoacid aminotransferase-like PLP-dependent enzymes0.006599Inherited
Rudiment single hybrid motif0.04332Inherited
Tetrahydrobiopterin biosynthesis enzymes-like0.04849Inherited
CoA-dependent acyltransferases0.09599Inherited
Class I glutamine amidotransferase-like0.3084Inherited
PFL-like glycyl radical enzymes0.3322Inherited
Glutamine synthetase/guanido kinase0.3824Inherited
Single hybrid motif0.54Inherited
Dihydropteroate synthetase-like0.9632Inherited
GHMP Kinase, C-terminal domain1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
AraD/HMP-PK domain-like1Inherited
Isocitrate/Isopropylmalate dehydrogenase-like1Inherited
FAD/NAD(P)-binding domain1Inherited
NagB/RpiA/CoA transferase-like1Inherited
Metallo-dependent hydrolases1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
PreATP-grasp domain1Inherited
FAH1Inherited
SAICAR synthase-like1Inherited
ClpP/crotonase1Inherited
RmlC-like cupins1Inherited
Ribosomal protein S5 domain 2-like1Inherited
FAD-linked reductases, C-terminal domain1Inherited
CheY-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54966,51649
  • 54966 - RuBisCO, large subunit, small (N-terminal) domain
  • 51649 - RuBisCo, C-terminal domain
  • 0Direct
    53383,55904
  • 53383 - PLP-dependent transferases
  • 55904 - Ornithine decarboxylase C-terminal domain
  • 0Direct
    52317,51366
  • 52317 - Class I glutamine amidotransferase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    54211,51366
  • 54211 - Ribosomal protein S5 domain 2-like
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    52467,52518
  • 52467 - DHS-like NAD/FAD-binding domain
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    51569,89000
  • 51569 - Aldolase
  • 89000 - post-HMGL domain-like
  • 0Direct
    56104,52255
  • 56104 - SAICAR synthase-like
  • 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    55821,142695
  • 55821 - YrdC/RibB
  • 142695 - RibA-like
  • 0Direct
    52172,53383
  • 52172 - CheY-like
  • 53383 - PLP-dependent transferases
  • 0Direct
    56529,56529
  • 56529 - FAH
  • 56529 - FAH
  • 0Direct
    55620,55083
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
  • 0Direct
    56322,52317
  • 56322 - ADC synthase
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    52317,47648
  • 52317 - Class I glutamine amidotransferase-like
  • 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
  • 0Direct
    52425,48173
  • 52425 - Cryptochrome/photolyase, N-terminal domain
  • 48173 - Cryptochrome/photolyase FAD-binding domain
  • 0Direct
    52507,102645
  • 52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
  • 102645 - CoaB-like
  • 0Direct
    51246,52255
  • 51246 - Rudiment single hybrid motif
  • 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
  • 0Direct
    51419,50621
  • 51419 - PLP-binding barrel
  • 50621 - Alanine racemase C-terminal domain-like
  • 0Direct
    53271,51366
  • 53271 - PRTase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    51366,51366
  • 51366 - Ribulose-phoshate binding barrel
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    52518,52467
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52467 - DHS-like NAD/FAD-binding domain
  • 0Direct
    55083,51717
  • 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
  • 51717 - Dihydropteroate synthetase-like
  • 0.00004046Direct
    55620,55620
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 0.0005338Direct
    100950,100950
  • 100950 - NagB/RpiA/CoA transferase-like
  • 100950 - NagB/RpiA/CoA transferase-like
  • 0.0009703Direct
    54368,55931
  • 54368 - Glutamine synthetase, N-terminal domain
  • 55931 - Glutamine synthetase/guanido kinase
  • 0.003342Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.04332Inherited
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0.9626Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 1Inherited
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 1Inherited
    54211,55060
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55060 - GHMP Kinase, C-terminal domain
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52172,53383,55904
  • 52172 - CheY-like
  • 53383 - PLP-dependent transferases
  • 55904 - Ornithine decarboxylase C-terminal domain
  • 0Direct
    56059,51246,52255
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
  • 0Direct
    52317,47648,52418
  • 52317 - Class I glutamine amidotransferase-like
  • 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
  • 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
  • 0Direct
    55620,55083,51717
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
  • 51717 - Dihydropteroate synthetase-like
  • 0Direct
    52518,52467,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52467 - DHS-like NAD/FAD-binding domain
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    52317,51366,51366
  • 52317 - Class I glutamine amidotransferase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    55620,55620,55083
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.04204Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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