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Carboxy-lyases

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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <6>
+ + 2:   Lyases [4] <7>(139|176) (158|94|34)
+ 1:   Carbon-carbon lyases [4.1] <4>(54|67) (59|30|8)
0:   Carboxy-lyases [4.1.1] <95>(40|48) (44|20|5)
- 1:   2,2-dialkylglycine decarboxylase (pyruvate) [4.1.1.64](0|0) (0|0|0)
- 1:   2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline deca [4.1.1.n1](1|1) (1|0|0)
- 1:   2-oxoglutarate decarboxylase [4.1.1.71](2|3) (2|1|0)
- 1:   3,4-dihydroxyphthalate decarboxylase [4.1.1.69](0|0) (0|0|0)
- 1:   3-dehydro-L-gulonate-6-phosphate decarboxylase [4.1.1.85](1|1) (1|0|0)
- 1:   3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-dec [4.1.1.51](0|0) (0|0|0)
- 1:   3-oxolaurate decarboxylase [4.1.1.56](0|0) (0|0|0)
- 1:   4,5-dihydroxyphthalate decarboxylase [4.1.1.55](0|0) (0|0|0)
- 1:   4-carboxymuconolactone decarboxylase [4.1.1.44](0|0) (0|0|0)
- 1:   4-hydroxybenzoate decarboxylase [4.1.1.61](0|0) (0|0|0)
- 1:   4-hydroxyphenylacetate decarboxylase [4.1.1.83](0|0) (1|0|0)
- 1:   4-hydroxyphenylpyruvate decarboxylase [4.1.1.80](0|0) (0|0|0)
- 1:   4-oxalocrotonate decarboxylase [4.1.1.77](0|0) (1|0|0)
- 1:   5-guanidino-2-oxopentanoate decarboxylase [4.1.1.75](0|0) (0|0|0)
- 1:   5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase [4.1.1.68](0|0) (1|1|0)
- 1:   6-methylsalicylate decarboxylase [4.1.1.52](0|0) (0|0|0)
- 1:   Acetoacetate decarboxylase [4.1.1.4](1|1) (1|0|0)
- 1:   Acetolactate decarboxylase [4.1.1.5](1|1) (1|0|0)
- 1:   Acetylenedicarboxylate decarboxylase [4.1.1.78](0|0) (0|0|0)
- 1:   Aconitate decarboxylase [4.1.1.6](0|0) (0|0|0)
- 1:   Adenosylmethionine decarboxylase [4.1.1.50](1|2) (1|0|0)
- 1:   Aminobenzoate decarboxylase [4.1.1.24](0|0) (0|0|0)
- 1:   Aminocarboxymuconate-semialdehyde decarboxylase [4.1.1.45](1|1) (1|0|0)
- 1:   Arginine decarboxylase [4.1.1.19](3|3) (4|1|0)
- 1:   Aromatic-L-amino-acid decarboxylase [4.1.1.28](1|1) (1|0|0)
- 1:   Arylmalonate decarboxylase [4.1.1.76](0|0) (0|0|0)
- 1:   Aspartate 1-decarboxylase [4.1.1.11](1|1) (1|0|0)
- 1:   Aspartate 4-decarboxylase [4.1.1.12](0|0) (0|0|0)
- 1:   Benzoylformate decarboxylase [4.1.1.7](0|0) (0|0|0)
- 1:   Biotin-dependent malonate decarboxylase [4.1.1.89](0|0) (0|0|0)
- 1:   Biotin-independent malonate decarboxylase [4.1.1.88](0|0) (0|0|0)
- 1:   Branched-chain-2-oxoacid decarboxylase [4.1.1.72](0|0) (0|0|0)
- 1:   Carnitine decarboxylase [4.1.1.42](0|0) (0|0|0)
- 1:   D-dopachrome decarboxylase [4.1.1.84](1|1) (1|0|0)
- 1:   Dehydro-L-gulonate decarboxylase [4.1.1.34](0|0) (0|0|0)
- 1:   Deleted entry [4.1.1.13](0|0) (0|0|0)
- 1:   Diaminobutyrate decarboxylase [4.1.1.86](0|0) (1|0|0)
- 1:   Diaminopimelate decarboxylase [4.1.1.20](2|2) (2|1|0)
- 1:   Dihydroxyfumarate decarboxylase [4.1.1.54](0|0) (0|0|0)
- 1:   Diphosphomevalonate decarboxylase [4.1.1.33](2|2) (2|1|0)
- 1:   Ethylmalonyl-CoA decarboxylase [4.1.1.n2](1|1) (0|0|0)
- 1:   Gallate decarboxylase [4.1.1.59](0|0) (0|0|0)
- 1:   Gentisate decarboxylase [4.1.1.62](0|0) (0|0|0)
- 1:   Glutaconyl-CoA decarboxylase [4.1.1.70](0|0) (0|0|0)
- 1:   Glutamate decarboxylase [4.1.1.15](3|3) (3|1|0)
- 1:   Histidine decarboxylase [4.1.1.22](2|2) (2|0|0)
- 1:   Hydroxyglutamate decarboxylase [4.1.1.16](0|0) (0|0|0)
- 1:   Hydroxypyruvate decarboxylase [4.1.1.40](0|0) (0|0|0)
- 1:   Indole-3-carboxylate decarboxylase [4.1.1.92](0|0) (0|0|0)
- 1:   Indole-3-glycerol-phosphate synthase [4.1.1.48](2|2) (2|2|1)
- 1:   Indolepyruvate decarboxylase [4.1.1.74](0|0) (0|0|0)
- 1:   Lysine decarboxylase [4.1.1.18](0|0) (2|1|0)
- 1:   Malonyl-CoA decarboxylase [4.1.1.9](0|0) (0|0|0)
- 1:   Malonyl-S-ACP decarboxylase [4.1.1.87](0|0) (0|0|0)
- 1:   Methionine decarboxylase [4.1.1.57](0|0) (0|0|0)
- 1:   Methylmalonyl-CoA decarboxylase [4.1.1.41](1|1) (1|0|0)
- 1:   Ornithine decarboxylase [4.1.1.17](2|2) (4|3|1)
- 1:   Orotidine-5'-phosphate decarboxylase [4.1.1.23](1|1) (1|1|0)
- 1:   Orsellinate decarboxylase [4.1.1.58](0|0) (0|0|0)
- 1:   Oxalate decarboxylase [4.1.1.2](0|0) (0|0|0)
- 1:   Oxaloacetate decarboxylase [4.1.1.3](1|1) (3|1|0)
- 1:   Oxalyl-CoA decarboxylase [4.1.1.8](0|0) (0|0|0)
- 1:   Pantothenoylcysteine decarboxylase [4.1.1.30](0|0) (0|0|0)
- 1:   Peptidyl-glutamate 4-carboxylase [4.1.1.90](1|0) (1|0|0)
- 1:   Phenylalanine decarboxylase [4.1.1.53](0|0) (0|0|0)
- 1:   Phenylpyruvate decarboxylase [4.1.1.43](0|0) (0|0|0)
- 1:   Phosphatidylserine decarboxylase [4.1.1.65](0|0) (0|0|0)
- 1:   Phosphoenolpyruvate carboxykinase (ATP) [4.1.1.49](2|2) (2|1|0)
- 1:   Phosphoenolpyruvate carboxykinase (GTP) [4.1.1.32](2|2) (2|1|0)
- 1:   Phosphoenolpyruvate carboxykinase (diphosphate) [4.1.1.38](0|0) (0|0|0)
- 1:   Phosphoenolpyruvate carboxylase [4.1.1.31](1|1) (1|0|0)
- 1:   Phosphonopyruvate decarboxylase [4.1.1.82](0|0) (0|0|0)
- 1:   Phosphopantothenoylcysteine decarboxylase [4.1.1.36](2|2) (2|1|0)
- 1:   Phosphoribosylaminoimidazole carboxylase [4.1.1.21](5|5) (5|4|2)
- 1:   Protocatechuate decarboxylase [4.1.1.63](0|0) (0|0|0)
- 1:   Pyrrole-2-carboxylate decarboxylase [4.1.1.93](0|0) (0|0|0)
- 1:   Pyruvate decarboxylase [4.1.1.1](2|3) (2|2|1)
- 1:   Ribulose-bisphosphate carboxylase [4.1.1.39](3|3) (3|1|0)
- 1:   Salicylate decarboxylase [4.1.1.91](0|0) (0|0|0)
- 1:   Stipitatonate decarboxylase [4.1.1.60](0|0) (0|0|0)
- 1:   Sulfinoalanine decarboxylase [4.1.1.29](0|0) (1|0|0)
- 1:   Sulfopyruvate decarboxylase [4.1.1.79](0|0) (1|0|0)
- 1:   Tartrate decarboxylase [4.1.1.73](1|1) (1|0|0)
- 1:   Tartronate-semialdehyde synthase [4.1.1.47](0|0) (0|0|0)
- 1:   Threonine-phosphate decarboxylase [4.1.1.81](1|1) (1|0|0)
- 1:   Transferred entry: 4.1.1.12 [4.1.1.10](0|0) (0|0|0)
- 1:   Transferred entry: 4.1.1.28 [4.1.1.26](0|0) (0|0|0)
- 1:   Transferred entry: 4.1.1.28 [4.1.1.27](0|0) (0|0|0)
- 1:   Tyrosine decarboxylase [4.1.1.25](1|1) (1|0|0)
- 1:   UDP-galacturonate decarboxylase [4.1.1.67](0|0) (0|0|0)
- 1:   UDP-glucuronate decarboxylase [4.1.1.35](1|1) (1|0|0)
- 1:   Uracil-5-carboxylate decarboxylase [4.1.1.66](0|0) (0|0|0)
- 1:   Uroporphyrinogen decarboxylase [4.1.1.37](1|1) (1|0|0)
- 1:   Valine decarboxylase [4.1.1.14](0|0) (0|0|0)
- 1:   o-pyrocatechuate decarboxylase [4.1.1.46](0|0) (0|0|0)


Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
PLP-binding barrel0Direct
RuBisCO, large subunit, small (N-terminal) domain0Direct
RuBisCo, C-terminal domain0Direct
AF0104/ALDC/Ptd012-like0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0Direct
Alanine racemase C-terminal domain-like0Direct
PEP carboxykinase N-terminal domain0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
S-adenosylmethionine decarboxylase0Direct
Acetoacetate decarboxylase-like0Direct
UROD/MetE-like0Direct
UraD-Like0Direct
ADC-like0Direct
Ornithine decarboxylase C-terminal domain0Direct
Pyruvoyl-dependent histidine and arginine decarboxylases0Direct
PEP carboxykinase-like0Direct
RuBisCO, small subunit0Direct
CoaB-like0Direct
Ribulose-phoshate binding barrel0Direct
Tautomerase/MIF0.000000001071Direct
Thiamin diphosphate-binding fold (THDP-binding)0.000002754Direct
DHS-like NAD/FAD-binding domain0.000005466Direct
FAH0.00009809Direct
Glutamine synthetase, N-terminal domain0.0002424Direct
Rudiment single hybrid motif0.004926Inherited
CoA-dependent acyltransferases0.01725Inherited
Glutamine synthetase/guanido kinase0.0952Inherited
RmlC-like cupins0.8946Inherited
SAICAR synthase-like0.9279Inherited
Class I glutamine amidotransferase-like1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
ClpP/crotonase1Inherited
GHMP Kinase, C-terminal domain1Inherited
Ribosomal protein S5 domain 2-like1Inherited
Phosphoenolpyruvate/pyruvate domain1Inherited
Isocitrate/Isopropylmalate dehydrogenase-like1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
PLP-dependent transferases1Inherited
PreATP-grasp domain1Inherited
Metallo-dependent hydrolases1Inherited


Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP term FDR (all) Annotation (direct or inherited)
Arginine decarboxylase0Direct
Uroporphyrinogen decarboxylase, UROD0Direct
PEP carboxykinase C-terminal domain0Direct
Decarboxylase0Direct
S-adenosylmethionine decarboxylase0Direct
Alpha-acetolactate decarboxylase-like0Direct
Mevalonate 5-diphosphate decarboxylase0Direct
Ornithine decarboxylase major domain0Direct
RuBisCO, small subunit0Direct
CoaB-like0Direct
Pyruvoyl dependent aspartate decarboxylase, ADC0Direct
Ribulose 1,5-bisphosphate carboxylase-oxygenase0Direct
Acetoacetate decarboxylase-like0Direct
Histidine decarboxylase0Direct
PEP carboxykinase N-terminal domain0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
Bacterial S-adenosylmethionine decarboxylase0Direct
Tryptophan biosynthesis enzymes0Direct
Alanine racemase-like, N-terminal domain0Direct
Phosphoenolpyruvate carboxylase0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0Direct
UraD-like0Direct
RuBisCo, large subunit, C-terminal domain0Direct
Eukaryotic ODC-like0Direct
Ornithine decarboxylase C-terminal domain0Direct
PP1699/LP2961-like0Direct
MIF-related0.0000000007811Direct
Pyruvate oxidase and decarboxylase PP module0.000001112Direct
Pyridoxal-dependent decarboxylase0.00000381Direct
Pyruvate oxidase and decarboxylase, middle domain0.000004153Direct
Pyruvate oxidase and decarboxylase Pyr module0.000005772Direct
FAH0.0001102Direct
Glutamine synthetase, N-terminal domain0.0002973Direct
Glutamine synthetase catalytic domain0.0004513Direct
CAT-like0.0005833Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0.0005983Direct
Branched-chain alpha-keto acid dehydrogenase PP module0.002014Inherited
BC C-terminal domain-like0.00618Inherited
BC ATP-binding domain-like0.4285Inherited
BC N-terminal domain-like0.5299Inherited
Dimeric isocitrate & isopropylmalate dehydrogenases0.7472Inherited
SAICAR synthase0.7543Inherited
Tyrosine-dependent oxidoreductases1Inherited
Crotonase-like1Inherited
GHMP Kinase, N-terminal domain1Inherited
AAT-like1Inherited
Class I glutamine amidotransferases (GAT)1Inherited
Phosphoenolpyruvate mutase/Isocitrate lyase-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
UraD-Like0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0Direct
AF0104/ALDC/Ptd012-like0Direct
ADC-like0Direct
PEP carboxykinase-like0Direct
UROD/MetE-like0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
RuBisCo, C-terminal domain0Direct
PEP carboxykinase N-terminal domain0Direct
Acetoacetate decarboxylase-like0Direct
S-adenosylmethionine decarboxylase0Direct
Ornithine decarboxylase C-terminal domain0Direct
Alanine racemase C-terminal domain-like0Direct
PLP-binding barrel0Direct
RuBisCO, small subunit0Direct
CoaB-like0Direct
Pyruvoyl-dependent histidine and arginine decarboxylases0Direct
Ribulose-phoshate binding barrel0Direct
RuBisCO, large subunit, small (N-terminal) domain0Direct
Tautomerase/MIF0.0000000008245Direct
Thiamin diphosphate-binding fold (THDP-binding)0.000002256Direct
DHS-like NAD/FAD-binding domain0.000004498Direct
FAH0.00008075Direct
Glutamine synthetase, N-terminal domain0.0001992Direct
Rudiment single hybrid motif0.004167Inherited
CoA-dependent acyltransferases0.01485Inherited
Glutamine synthetase/guanido kinase0.0841Inherited
PFL-like glycyl radical enzymes0.1376Inherited
Single hybrid motif0.266Inherited
RmlC-like cupins0.8395Inherited
SAICAR synthase-like0.8719Inherited
CheY-like0.8777Inherited
GHMP Kinase, C-terminal domain1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Isocitrate/Isopropylmalate dehydrogenase-like1Inherited
post-HMGL domain-like1Inherited
Metallo-dependent hydrolases1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
PLP-dependent transferases1Inherited
PreATP-grasp domain1Inherited
ClpP/crotonase1Inherited
Phosphoenolpyruvate/pyruvate domain1Inherited
Class I glutamine amidotransferase-like1Inherited
Ribosomal protein S5 domain 2-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54966,51649
  • 54966 - RuBisCO, large subunit, small (N-terminal) domain
  • 51649 - RuBisCo, C-terminal domain
  • 0Direct
    53383,55904
  • 53383 - PLP-dependent transferases
  • 55904 - Ornithine decarboxylase C-terminal domain
  • 0Direct
    52317,51366
  • 52317 - Class I glutamine amidotransferase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    56104,52255
  • 56104 - SAICAR synthase-like
  • 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    52172,53383
  • 52172 - CheY-like
  • 53383 - PLP-dependent transferases
  • 0Direct
    56529,56529
  • 56529 - FAH
  • 56529 - FAH
  • 0Direct
    52507,102645
  • 52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
  • 102645 - CoaB-like
  • 0Direct
    51246,52255
  • 51246 - Rudiment single hybrid motif
  • 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
  • 0Direct
    51419,50621
  • 51419 - PLP-binding barrel
  • 50621 - Alanine racemase C-terminal domain-like
  • 0Direct
    53271,51366
  • 53271 - PRTase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    51366,51366
  • 51366 - Ribulose-phoshate binding barrel
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    52467,52518
  • 52467 - DHS-like NAD/FAD-binding domain
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0.000004498Direct
    52518,52467
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52467 - DHS-like NAD/FAD-binding domain
  • 0.000006233Direct
    54368,55931
  • 54368 - Glutamine synthetase, N-terminal domain
  • 55931 - Glutamine synthetase/guanido kinase
  • 0.0001992Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.004167Inherited
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0.7126Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 1Inherited
    51569,89000
  • 51569 - Aldolase
  • 89000 - post-HMGL domain-like
  • 1Inherited
    54211,55060
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55060 - GHMP Kinase, C-terminal domain
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52172,53383,55904
  • 52172 - CheY-like
  • 53383 - PLP-dependent transferases
  • 55904 - Ornithine decarboxylase C-terminal domain
  • 0Direct
    56059,51246,52255
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
  • 0Direct
    52317,51366,51366
  • 52317 - Class I glutamine amidotransferase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    52518,52467,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52467 - DHS-like NAD/FAD-binding domain
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0.000006233Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.004014Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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