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Carbon-oxygen lyases

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <6>
+ 1:   Lyases [4] <7>(139|176) (158|94|34)
0:   Carbon-oxygen lyases [4.2] <4>(68|83) (76|43|20)
- 1:   Hydro-lyases [4.2.1] <132>(51|57) (55|33|16)
- 1:   Acting on phosphates [4.2.3] <116>(11|14) (11|7|5)
- 1:   Acting on polysaccharides [4.2.2] <27>(8|11) (10|6|2)
- 1:   Other carbon-oxygen lyases [4.2.99] <22>(7|9) (9|3|1)


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Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
Urocanase0Direct
Hyaluronate lyase-like, C-terminal domain0Direct
Glucocorticoid receptor-like (DNA-binding domain)0Direct
HemD-like0Direct
Terpenoid synthases0Direct
DNA-glycosylase0Direct
PCD-like0Direct
lambda repressor-like DNA-binding domains0Direct
N-terminal domain of MutM-like DNA repair proteins0Direct
S13-like H2TH domain0Direct
Cyanase C-terminal domain0Direct
Chorismate synthase, AroC0Direct
IlvD/EDD N-terminal domain-like0Direct
LeuD/IlvD-like0Direct
beta-carbonic anhydrase, cab0Direct
ClpP/crotonase0Direct
Carbonic anhydrase0Direct
6-phosphogluconate dehydrogenase C-terminal domain-like0Direct
Ribosomal protein S5 domain 2-like0Direct
2-methylcitrate dehydratase PrpD0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Type II 3-dehydroquinate dehydratase0Direct
Aconitase B, N-terminal domain0Direct
Methylglyoxal synthase-like0Direct
Lysozyme-like0Direct
Enolase C-terminal domain-like0Direct
SIS domain0Direct
Enolase N-terminal domain-like0Direct
Xylose isomerase-like0Direct
FumA C-terminal domain-like0Direct
Dehydroquinate synthase-like0Direct
Aconitase iron-sulfur domain0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
Chondroitin AC/alginate lyase0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
Periplasmic binding protein-like II0Direct
Pectin lyase-like0Direct
AraD/HMP-PK domain-like0.00000000000006457Direct
Nitrile hydratase alpha chain0.000000000006026Direct
Chorismate mutase II0.000000001216Direct
Electron transport accessory proteins0.000000003254Direct
TATA-box binding protein-like0.0000008941Direct
Starch-binding domain-like0.00007566Direct
DNase I-like0.000942Direct
RmlC-like cupins0.002068Inherited
Galactose mutarotase-like0.00308Inherited
CBS-domain pair0.009418Inherited
Ribokinase-like0.02108Inherited
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.04742Inherited
HAD-like0.08974Inherited
ACT-like0.165Inherited
FAH0.1882Inherited
FabD/lysophospholipase-like0.2621Inherited
EPT/RTPC-like0.4731Inherited
ACP-like0.4832Inherited
Aminoacid dehydrogenase-like, N-terminal domain0.9532Inherited
Aldolase1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
Galactose-binding domain-like1Inherited
Class I glutamine amidotransferase-like1Inherited
GroES-like1Inherited
Thiolase-like1Inherited
Cytochrome P4501Inherited
Tetrahydrobiopterin biosynthesis enzymes-like1Inherited
alpha/beta-Hydrolases1Inherited
L-aspartase-like1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Ribulose-phoshate binding barrel1Inherited


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Family

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SCOP term FDR (all) Annotation (direct or inherited)
Rhamnogalacturonase B, RhgB, middle domain0Direct
N-terminal domain of MutM-like DNA repair proteins0Direct
Enolase N-terminal domain-like0Direct
Dimeric chorismate mutase0Direct
Crotonase-like0Direct
C-terminal, Zn-finger domain of MutM-like DNA repair proteins0Direct
HCDH C-domain-like0Direct
Cyanase N-terminal domain0Direct
MaoC-like0Direct
lvD/EDD N-terminal domain-like0Direct
Histidinol phosphatase-like0Direct
Urocanase0Direct
IlvD/EDD C-terminal domain-like0Direct
Middle domain of MutM-like DNA repair proteins0Direct
Type II 3-dehydroquinate dehydratase0Direct
Chorismate synthase, AroC0Direct
Terpenoid cyclase C-terminal domain0Direct
2-methylcitrate dehydratase PrpD0Direct
Bacterial muramidase, catalytic domain0Direct
UxuA-like0Direct
beta-Hydroxydecanol thiol ester dehydrase0Direct
Endonuclease III0Direct
Rhamnogalacturonase B, RhgB, N-terminal domain0Direct
FumA C-terminal domain-like0Direct
Dehydroquinate synthase, DHQS0Direct
Methylglyoxal synthase, MgsA0Direct
Enolase0Direct
Rhamnogalacturonase B, RhgB, C-terminal domain0Direct
Terpenoid cyclase N-terminal domain0Direct
6-pyruvoyl tetrahydropterin synthase0Direct
Aconitase iron-sulfur domain0Direct
LeuD-like0Direct
PCD-like0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Pectin lyase0Direct
Cyanase C-terminal domain0Direct
Aristolochene/pentalenene synthase0Direct
Alginate lyase A1-III0Direct
mono-SIS domain0Direct
beta-carbonic anhydrase, cab0Direct
AgoG-like0Direct
Aconitase B, N-terminal domain0Direct
Trichodiene synthase0Direct
Pectate lyase-like0Direct
DJ-1/PfpI0Direct
YjeF C-terminal domain-like0Direct
Hyaluronate lyase-like catalytic, N-terminal domain0Direct
HemD-like0Direct
Carbonic anhydrase0Direct
Hyaluronate lyase-like, central domain0Direct
Imidazole glycerol phosphate dehydratase0Direct
D-glucarate dehydratase-like0Direct
Hypothetical protein VC19740Direct
5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)0Direct
6-phosphogluconate dehydrogenase-like, N-terminal domain0Direct
Hyaluronate lyase-like, C-terminal domain0Direct
Phosphate binding protein-like0.00000000000001851Direct
Shikimate kinase (AroK)0.00000000000002609Direct
AraD-like aldolase/epimerase0.000000000000037Direct
DNase I-like0.000000000001978Direct
Phenylalanine metabolism regulatory domain0.000000000002069Direct
Nitrile hydratase beta chain0.000000000007147Direct
Nitrile hydratase alpha chain0.000000000007147Direct
Shikimate dehydrogenase-like0.00000000006722Direct
Acyl-carrier protein (ACP)0.000000039Direct
DNA repair glycosylase, N-terminal domain0.0000009581Direct
Class I aldolase0.000001643Direct
DNA repair glycosylase, 2 C-terminal domains0.000002634Direct
Thioesterase domain of polypeptide, polyketide and fatty acid synthases0.0000441Direct
FabD-like0.0003684Direct
Terpene synthases0.003186Inherited
CBS-domain pair0.009939Inherited
Tryptophan biosynthesis enzymes0.02023Inherited
FAH0.1648Inherited
Tyrosine-dependent oxidoreductases0.1661Inherited
Enolase-phosphatase E10.2985Inherited
Enolpyruvate transferase, EPT0.354Inherited
Thiolase-related1Inherited
Alcohol dehydrogenase-like, N-terminal domain1Inherited
Cytochrome P4501Inherited
Alcohol dehydrogenase-like, C-terminal domain1Inherited
Aminoacid dehydrogenase-like, C-terminal domain1Inherited
L-aspartase/fumarase1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Type II 3-dehydroquinate dehydratase0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
Enolase C-terminal domain-like0Direct
N-terminal domain of MutM-like DNA repair proteins0Direct
2-methylcitrate dehydratase PrpD0Direct
HemD-like0Direct
S13-like H2TH domain0Direct
Chondroitin AC/alginate lyase0Direct
DNA-glycosylase0Direct
Dehydroquinate synthase-like0Direct
Carbonic anhydrase0Direct
Terpenoid synthases0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Chorismate synthase, AroC0Direct
IlvD/EDD N-terminal domain-like0Direct
lambda repressor-like DNA-binding domains0Direct
Bacterial muramidases0Direct
beta-carbonic anhydrase, cab0Direct
Enolase N-terminal domain-like0Direct
Aconitase iron-sulfur domain0Direct
6-phosphogluconate dehydrogenase C-terminal domain-like0Direct
FumA C-terminal domain-like0Direct
Aconitase B, N-terminal domain0Direct
Lysozyme-like0Direct
SIS domain0Direct
Pectin lyase-like0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
Urocanase0Direct
Glucocorticoid receptor-like (DNA-binding domain)0Direct
ClpP/crotonase0Direct
PCD-like0Direct
LeuD/IlvD-like0Direct
Periplasmic binding protein-like II0Direct
Xylose isomerase-like0Direct
Cyanase C-terminal domain0Direct
Hyaluronate lyase-like, C-terminal domain0Direct
Ribosomal protein S5 domain 2-like0Direct
Methylglyoxal synthase-like0Direct
AraD/HMP-PK domain-like0.00000000000004906Direct
Nitrile hydratase alpha chain0.00000000000451Direct
Chorismate mutase II0.0000000009321Direct
Electron transport accessory proteins0.00000000252Direct
TATA-box binding protein-like0.0000007164Direct
Starch-binding domain-like0.00006164Direct
Barwin-like endoglucanases0.0001772Direct
DNase I-like0.000715Direct
Galactose mutarotase-like0.001182Inherited
SCP-like0.00151Inherited
RmlC-like cupins0.001684Inherited
Ran binding protein zinc finger-like0.004464Inherited
CBS-domain pair0.008898Inherited
Ribokinase-like0.01777Inherited
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.04164Inherited
SMAD/FHA domain0.07368Inherited
HAD-like0.1159Inherited
ACT-like0.1498Inherited
FAH0.1713Inherited
FabD/lysophospholipase-like0.2381Inherited
UBA-like0.2385Inherited
NTF2-like0.2882Inherited
EPT/RTPC-like0.431Inherited
ACP-like0.4474Inherited
Aminoacid dehydrogenase-like, N-terminal domain0.8927Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
FAD/NAD(P)-binding domain1Inherited
Aldolase1Inherited
GroES-like1Inherited
Cytochrome P4501Inherited
L-aspartase-like1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
alpha/beta-Hydrolases1Inherited
Galactose-binding domain-like1Inherited
Thiolase-like1Inherited
Class I glutamine amidotransferase-like1Inherited
Tetrahydrobiopterin biosynthesis enzymes-like1Inherited
Ribulose-phoshate binding barrel1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55205,52540
  • 55205 - EPT/RTPC-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48230,74650
  • 48230 - Chondroitin AC/alginate lyase
  • 74650 - Galactose mutarotase-like
  • 0Direct
    53732,52016
  • 53732 - Aconitase iron-sulfur domain
  • 52016 - LeuD/IlvD-like
  • 0Direct
    51735,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    49452,49785
  • 49452 - Starch-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    53850,53955
  • 53850 - Periplasmic binding protein-like II
  • 53955 - Lysozyme-like
  • 0Direct
    56784,54211
  • 56784 - HAD-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    54637,55718
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 55718 - SCP-like
  • 0Direct
    51569,53223
  • 51569 - Aldolase
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 0Direct
    53686,54631
  • 53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
  • 54631 - CBS-domain pair
  • 0Direct
    48600,53850
  • 48600 - Chorismate mutase II
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    52016,53732
  • 52016 - LeuD/IlvD-like
  • 53732 - Aconitase iron-sulfur domain
  • 0Direct
    52540,51569
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51569 - Aldolase
  • 0Direct
    51366,53686
  • 51366 - Ribulose-phoshate binding barrel
  • 53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes
  • 0Direct
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    47413,55234
  • 47413 - lambda repressor-like DNA-binding domains
  • 55234 - Cyanase C-terminal domain
  • 0Direct
    74650,49863
  • 74650 - Galactose mutarotase-like
  • 49863 - Hyaluronate lyase-like, C-terminal domain
  • 0Direct
    46946,57716
  • 46946 - S13-like H2TH domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    53639,56784
  • 53639 - AraD/HMP-PK domain-like
  • 56784 - HAD-like
  • 0Direct
    54637,52151
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    48239,48239
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 0Direct
    81624,46946
  • 81624 - N-terminal domain of MutM-like DNA repair proteins
  • 46946 - S13-like H2TH domain
  • 0Direct
    143975,52016
  • 143975 - IlvD/EDD N-terminal domain-like
  • 52016 - LeuD/IlvD-like
  • 0Direct
    52096,51735
  • 52096 - ClpP/crotonase
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    53697,46934
  • 53697 - SIS domain
  • 46934 - UBA-like
  • 0Direct
    74778,52016
  • 74778 - Aconitase B, N-terminal domain
  • 52016 - LeuD/IlvD-like
  • 0Direct
    53850,55021
  • 53850 - Periplasmic binding protein-like II
  • 55021 - ACT-like
  • 0Direct
    54211,54211
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    48435,53955
  • 48435 - Bacterial muramidases
  • 53955 - Lysozyme-like
  • 0Direct
    74650,49452
  • 74650 - Galactose mutarotase-like
  • 49452 - Starch-binding domain-like
  • 0Direct
    56796,55205
  • 56796 - Dehydroquinate synthase-like
  • 55205 - EPT/RTPC-like
  • 0Direct
    54826,51604
  • 54826 - Enolase N-terminal domain-like
  • 51604 - Enolase C-terminal domain-like
  • 0Direct
    48239,48576
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 48576 - Terpenoid synthases
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0.0000000249Direct
    47336,53474
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 0.0000001897Direct
    55945,48150
  • 55945 - TATA-box binding protein-like
  • 48150 - DNA-glycosylase
  • 0.0000007164Direct
    51735,51735
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.000007789Direct
    48179,52096
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52096 - ClpP/crotonase
  • 0.000009901Direct
    51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.0009253Direct
    52151,55048
  • 52151 - FabD/lysophospholipase-like
  • 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase
  • 0.04164Inherited
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.6452Inherited
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    56796,55205,52540
  • 56796 - Dehydroquinate synthase-like
  • 55205 - EPT/RTPC-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51735,54637,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    51735,51735,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    48239,48239,48576
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 48576 - Terpenoid synthases
  • 0Direct
    54637,54637,55718
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 55718 - SCP-like
  • 0Direct
    74650,49452,49785
  • 74650 - Galactose mutarotase-like
  • 49452 - Starch-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    51569,53223,51735
  • 51569 - Aldolase
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    81624,46946,57716
  • 81624 - N-terminal domain of MutM-like DNA repair proteins
  • 46946 - S13-like H2TH domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    74778,52016,53732
  • 74778 - Aconitase B, N-terminal domain
  • 52016 - LeuD/IlvD-like
  • 53732 - Aconitase iron-sulfur domain
  • 0Direct
    55205,52540,51569
  • 55205 - EPT/RTPC-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51569 - Aldolase
  • 0Direct
    48600,53850,55021
  • 48600 - Chorismate mutase II
  • 53850 - Periplasmic binding protein-like II
  • 55021 - ACT-like
  • 0Direct
    52096,51735,48179
  • 52096 - ClpP/crotonase
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    56784,54211,54211
  • 56784 - HAD-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52540,51569,53223
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51569 - Aldolase
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 0Direct
    48230,74650,49863
  • 48230 - Chondroitin AC/alginate lyase
  • 74650 - Galactose mutarotase-like
  • 49863 - Hyaluronate lyase-like, C-terminal domain
  • 0Direct
    51735,47336,53474
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 0.00000002889Direct
    48179,48179,52096
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52096 - ClpP/crotonase
  • 0.000009901Direct
    50129,51735,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.000019Direct
    51735,51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.0005297Direct


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
    Plot tree as:   Download Newick format tree:
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