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Isomerases
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Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.
Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.
EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).
Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEO level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term |
FDR (all) |
Annotation (direct or inherited) |
Phosphoglucomutase, first 3 domains | 0 | DIRECT |
Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | DIRECT |
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | 0 | DIRECT |
PLP-binding barrel | 0 | DIRECT |
FKBP-like | 0 | DIRECT |
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 0 | DIRECT |
ERP29 C domain-like | 0 | DIRECT |
FucI/AraA C-terminal domain-like | 0 | DIRECT |
Triger factor/SurA peptide-binding domain-like | 0 | DIRECT |
Type II DNA topoisomerase | 0 | DIRECT |
TPR-like | 0 | DIRECT |
Zinc beta-ribbon | 0 | DIRECT |
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
Kelch motif | 0 | DIRECT |
Ribose/Galactose isomerase RpiB/AlsB | 0 | DIRECT |
DNA breaking-rejoining enzymes | 0 | DIRECT |
Alanine racemase C-terminal domain-like | 0 | DIRECT |
GyrA/ParC C-terminal domain-like | 0 | DIRECT |
Phosphoglycerate mutase-like | 0 | DIRECT |
RbsD-like | 0 | DIRECT |
RmlC-like cupins | 0 | DIRECT |
PTPA-like | 0 | DIRECT |
Dimeric alpha+beta barrel | 0 | DIRECT |
Alkaline phosphatase-like | 0 | DIRECT |
NagB/RpiA/CoA transferase-like | 0 | DIRECT |
PUA domain-like | 0 | DIRECT |
Cyclophilin-like | 0 | DIRECT |
Cobalamin (vitamin B12)-binding domain | 0 | DIRECT |
DNA topoisomerase IV, alpha subunit | 0 | DIRECT |
Diaminopimelate epimerase-like | 0 | DIRECT |
Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
Pseudouridine synthase | 0 | DIRECT |
Chalcone isomerase | 0 | DIRECT |
Trigger factor ribosome-binding domain | 0 | DIRECT |
DeoB insert domain-like | 0 | DIRECT |
Triosephosphate isomerase (TIM) | 0 | DIRECT |
SIS domain | 0 | DIRECT |
Aspartate/glutamate racemase | 0 | DIRECT |
FucI/AraA N-terminal and middle domains | 0 | DIRECT |
Xylose isomerase-like | 0 | DIRECT |
Nudix | 0 | DIRECT |
PLP-dependent transferases | 0 | DIRECT |
D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | DIRECT |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
Ribulose-phoshate binding barrel | 0 | DIRECT |
Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
FMN-linked oxidoreductases | 0 | DIRECT |
Chorismate mutase II | 0 | DIRECT |
Cobalamin (vitamin B12)-dependent enzymes | 0 | DIRECT |
Lipocalins | 0.00000000000004383 | DIRECT |
Tautomerase/MIF | 0.0000000000005537 | DIRECT |
Alpha-L RNA-binding motif | 0.000000000001001 | DIRECT |
ClpP/crotonase | 0.000000000008328 | DIRECT |
6-phosphogluconate dehydrogenase C-terminal domain-like | 0.00000000001634 | DIRECT |
Thioredoxin-like | 0.000000004463 | DIRECT |
RNA-binding domain, RBD | 0.000002211 | DIRECT |
WW domain | 0.00004689 | DIRECT |
ADC synthase | 0.0005844 | DIRECT |
MAPEG domain-like | 0.0006234 | DIRECT |
Hedgehog/intein (Hint) domain | 0.0007016 | DIRECT |
AraD/HMP-PK domain-like | 0.0009987 | DIRECT |
Homing endonucleases | 0.001094 | INHERITED FROM: DNA topoisomerase (ATP-hydrolyzing) || Other isomerases |
Terpenoid synthases | 0.003908 | INHERITED FROM: Copalyl diphosphate synthase || Intramolecular lyases || Ent-copalyl diphosphate synthase || Lycopene beta-cyclase |
Galactose mutarotase-like | 0.02 | INHERITED FROM: Aldose 1-epimerase || Acting on carbohydrates and derivatives || Racemases and epimerases |
RING/U-box | 0.0228 | INHERITED FROM: Cis-trans-isomerases || Peptidylprolyl isomerase |
WD40 repeat-like | 0.08889 | INHERITED FROM: Cis-trans-isomerases || Peptidylprolyl isomerase |
Di-copper centre-containing domain | 0.1491 | INHERITED FROM: L-dopachrome isomerase || Transposing C==C bonds |
CBS-domain pair | 0.3306 | INHERITED FROM: Arabinose-5-phosphate isomerase |
ACP-like | 0.3969 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) || Racemases and epimerases || Acting on amino acids and derivatives |
GST C-terminal domain-like | 0.6406 | INHERITED FROM: Other intramolecular oxidoreductases || Cis-trans-isomerases || Maleylacetoacetate isomerase |
Metallo-dependent hydrolases | 0.6788 | INHERITED FROM: Glucuronate isomerase || Interconverting aldoses and ketoses, and related c || Intramolecular oxidoreductases |
EF-hand | 0.8525 | INHERITED FROM: Cis-trans-isomerases || Peptidylprolyl isomerase |
UDP-Glycosyltransferase/glycogen phosphorylase | 1 | INHERITED FROM: Acting on carbohydrates and derivatives || UDP-N-acetylglucosamine 2-epimerase |
Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: UDP-arabinopyranose mutase || Mannose-6-phosphate isomerase |
RuBisCO, large subunit, small (N-terminal) domain | 1 | INHERITED FROM: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase || Interconverting keto- and enol- groups |
RuBisCo, C-terminal domain | 1 | INHERITED FROM: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase || Interconverting keto- and enol- groups |
CoA-dependent acyltransferases | 1 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) || Acting on amino acids and derivatives |
S13-like H2TH domain | 1 | INHERITED FROM: DNA topoisomerase (ATP-hydrolyzing) || Other isomerases |
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Intramolecular lyases || Inositol-3-phosphate synthase |
Class I glutamine amidotransferase-like | 1 | INHERITED FROM: Phosphoribosylanthranilate isomerase |
Acetyl-CoA synthetase-like | 1 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) |
Ribosomal protein S5 domain 2-like | 1 | INHERITED FROM: DNA topoisomerase (ATP-hydrolyzing) || Other isomerases |
HAD-like | 1 | INHERITED FROM: Phosphomannomutase || Phosphotransferases (phosphomutases) |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | INHERITED FROM: Serine racemase |
Six-hairpin glycosidases | 1 | INHERITED FROM: N-acylglucosamine 2-epimerase || Acting on carbohydrates and derivatives |
Cytochrome P450 | 1 | INHERITED FROM: Other intramolecular oxidoreductases || Thromboxane-A synthase |
Enolase C-terminal domain-like | 1 | INHERITED FROM: Intramolecular lyases || Chloromuconate cycloisomerase || Muconate cycloisomerase |
ACT-like | 1 | INHERITED FROM: Chorismate mutase |
Enolase N-terminal domain-like | 1 | INHERITED FROM: Intramolecular lyases || Chloromuconate cycloisomerase || Muconate cycloisomerase |
NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: ADP-glyceromanno-heptose 6-epimerase || Intramolecular lyases || Steroid Delta-isomerase || Acting on carbohydrates and derivatives || 3-hydroxybutyryl-CoA epimerase || Acting on hydroxy acids and derivatives || Transposing C==C bonds || Inositol-3-phosphate synthase || Racemases and epimerases || Dodecenoyl-CoA isomerase || UDP-glucose 4-epimerase |
FAD/NAD(P)-binding domain | 1 | INHERITED FROM: Ribose 1,5-bisphosphate isomerase || Prolycopene isomerase || Lycopene beta-cyclase |
Periplasmic binding protein-like II | 1 | INHERITED FROM: Chorismate mutase |
SCOP term |
FDR (all) |
Annotation (direct or inherited) |
Phosphoglucomutase, first 3 domains | 0 | Direct |
Phosphoglucomutase, C-terminal domain | 0 | Direct |
Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | Direct |
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | 0 | Direct |
PLP-binding barrel | 0 | Direct |
FKBP-like | 0 | Direct |
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 0 | Direct |
ERP29 C domain-like | 0 | Direct |
FucI/AraA C-terminal domain-like | 0 | Direct |
Triger factor/SurA peptide-binding domain-like | 0 | Direct |
Type II DNA topoisomerase | 0 | Direct |
TPR-like | 0 | Direct |
Zinc beta-ribbon | 0 | Direct |
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
Kelch motif | 0 | Direct |
Ribose/Galactose isomerase RpiB/AlsB | 0 | Direct |
DNA breaking-rejoining enzymes | 0 | Direct |
Alanine racemase C-terminal domain-like | 0 | Direct |
GyrA/ParC C-terminal domain-like | 0 | Direct |
Phosphoglycerate mutase-like | 0 | Direct |
RbsD-like | 0 | Direct |
RmlC-like cupins | 0 | Direct |
PTPA-like | 0 | Direct |
Dimeric alpha+beta barrel | 0 | Direct |
Alkaline phosphatase-like | 0 | Direct |
NagB/RpiA/CoA transferase-like | 0 | Direct |
PUA domain-like | 0 | Direct |
Cyclophilin-like | 0 | Direct |
Cobalamin (vitamin B12)-binding domain | 0 | Direct |
DNA topoisomerase IV, alpha subunit | 0 | Direct |
Diaminopimelate epimerase-like | 0 | Direct |
Prokaryotic type I DNA topoisomerase | 0 | Direct |
Pseudouridine synthase | 0 | Direct |
Chalcone isomerase | 0 | Direct |
Trigger factor ribosome-binding domain | 0 | Direct |
DeoB insert domain-like | 0 | Direct |
Triosephosphate isomerase (TIM) | 0 | Direct |
SIS domain | 0 | Direct |
Aspartate/glutamate racemase | 0 | Direct |
FucI/AraA N-terminal and middle domains | 0 | Direct |
Xylose isomerase-like | 0 | Direct |
Nudix | 0 | Direct |
PLP-dependent transferases | 0 | Direct |
D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | Direct |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
Ribulose-phoshate binding barrel | 0 | Direct |
Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
FMN-linked oxidoreductases | 0 | Direct |
Chorismate mutase II | 0 | Direct |
Cobalamin (vitamin B12)-dependent enzymes | 0 | Direct |
Lipocalins | 0.00000000000004383 | Direct |
Tautomerase/MIF | 0.0000000000005537 | Direct |
Alpha-L RNA-binding motif | 0.000000000001001 | Direct |
ClpP/crotonase | 0.000000000008328 | Direct |
6-phosphogluconate dehydrogenase C-terminal domain-like | 0.00000000001634 | Direct |
Thioredoxin-like | 0.000000004463 | Direct |
RNA-binding domain, RBD | 0.000002211 | Direct |
WW domain | 0.00004689 | Direct |
ADC synthase | 0.0005844 | Direct |
MAPEG domain-like | 0.0006234 | Direct |
Hedgehog/intein (Hint) domain | 0.0007016 | Direct |
AraD/HMP-PK domain-like | 0.0009987 | Direct |
Homing endonucleases | 0.001094 | Inherited |
Terpenoid synthases | 0.003908 | Inherited |
Galactose mutarotase-like | 0.02 | Inherited |
RING/U-box | 0.0228 | Inherited |
WD40 repeat-like | 0.08889 | Inherited |
Di-copper centre-containing domain | 0.1491 | Inherited |
CBS-domain pair | 0.3306 | Inherited |
ACP-like | 0.3969 | Inherited |
GST C-terminal domain-like | 0.6406 | Inherited |
Metallo-dependent hydrolases | 0.6788 | Inherited |
EF-hand | 0.8525 | Inherited |
UDP-Glycosyltransferase/glycogen phosphorylase | 1 | Inherited |
Nucleotide-diphospho-sugar transferases | 1 | Inherited |
RuBisCO, large subunit, small (N-terminal) domain | 1 | Inherited |
RuBisCo, C-terminal domain | 1 | Inherited |
CoA-dependent acyltransferases | 1 | Inherited |
S13-like H2TH domain | 1 | Inherited |
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | Inherited |
Class I glutamine amidotransferase-like | 1 | Inherited |
Acetyl-CoA synthetase-like | 1 | Inherited |
Ribosomal protein S5 domain 2-like | 1 | Inherited |
HAD-like | 1 | Inherited |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | Inherited |
Six-hairpin glycosidases | 1 | Inherited |
Cytochrome P450 | 1 | Inherited |
Enolase C-terminal domain-like | 1 | Inherited |
ACT-like | 1 | Inherited |
Enolase N-terminal domain-like | 1 | Inherited |
NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
FAD/NAD(P)-binding domain | 1 | Inherited |
Periplasmic binding protein-like II | 1 | Inherited |
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this (SDEO level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term |
FDR (all) |
Annotation (direct or inherited) |
Topoisomerase VI-B subunit middle domain | 0 | DIRECT |
D-ribose-5-phosphate isomerase (RpiA), catalytic domain | 0 | DIRECT |
Thi4-like | 0 | DIRECT |
Tyrosine-dependent oxidoreductases | 0 | DIRECT |
UDP-N-acetylglucosamine 2-epimerase | 0 | DIRECT |
AraA N-terminal and middle domain-like | 0 | DIRECT |
Crotonase-like | 0 | DIRECT |
Aspartate/glutamate racemase | 0 | DIRECT |
N-acylglucosamine (NAG) epimerase | 0 | DIRECT |
HCDH C-domain-like | 0 | DIRECT |
Retinol binding protein-like | 0 | DIRECT |
PDI-like | 0 | DIRECT |
Glucose-6-phosphate isomerase, GPI | 0 | DIRECT |
Type I phosphomannose isomerase | 0 | DIRECT |
Prokaryotic DNA topoisomerase I, a C-terminal fragment | 0 | DIRECT |
DNA gyrase/MutL, second domain | 0 | DIRECT |
PUA domain | 0 | DIRECT |
Pseudouridine synthase RsuA N-terminal domain | 0 | DIRECT |
Alanine racemase | 0 | DIRECT |
dTDP-sugar isomerase | 0 | DIRECT |
Diaminopimelate epimerase | 0 | DIRECT |
Cobalamin (vitamin B12)-binding domain | 0 | DIRECT |
DNA topoisomerase IV, alpha subunit | 0 | DIRECT |
Terpene synthases | 0 | DIRECT |
AraA C-terminal domain-like | 0 | DIRECT |
Helicase-like "domain" of reverse gyrase | 0 | DIRECT |
Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
Pseudouridine synthase II TruB | 0 | DIRECT |
Triosephosphate isomerase (TIM) | 0 | DIRECT |
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 0 | DIRECT |
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain | 0 | DIRECT |
PTPA-like | 0 | DIRECT |
DeoB catalytic domain-like | 0 | DIRECT |
KduI-like | 0 | DIRECT |
Pseudouridine synthase RsuA/RluD | 0 | DIRECT |
D-ribulose-5-phosphate 3-epimerase | 0 | DIRECT |
L-fucose isomerase, C-terminal domain | 0 | DIRECT |
Tetratricopeptide repeat (TPR) | 0 | DIRECT |
YiiL-like | 0 | DIRECT |
Aldose 1-epimerase (mutarotase) | 0 | DIRECT |
ERP29 C domain-like | 0 | DIRECT |
IF2B-like | 0 | DIRECT |
DeoB insert domain-like | 0 | DIRECT |
Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
GyrA/ParC C-terminal domain-like | 0 | DIRECT |
RbsD-like | 0 | DIRECT |
Cofactor-dependent phosphoglycerate mutase | 0 | DIRECT |
D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | DIRECT |
Proline racemase | 0 | DIRECT |
Cyclophilin (peptidylprolyl isomerase) | 0 | DIRECT |
Xylose isomerase | 0 | DIRECT |
Phosphoglucose isomerase, PGI | 0 | DIRECT |
Hypothetical protein YgbM (EC1530) | 0 | DIRECT |
IPP isomerase-like | 0 | DIRECT |
Histidine biosynthesis enzymes | 0 | DIRECT |
Pseudouridine synthase I TruA | 0 | DIRECT |
mono-SIS domain | 0 | DIRECT |
Methylmalonyl-CoA mutase, N-terminal (CoA-binding) domain | 0 | DIRECT |
Porin chaperone SurA, peptide-binding domain | 0 | DIRECT |
Tryptophan biosynthesis enzymes | 0 | DIRECT |
Alanine racemase-like, N-terminal domain | 0 | DIRECT |
Type II DNA topoisomerase | 0 | DIRECT |
Kelch motif | 0 | DIRECT |
tRNA pseudouridine synthase TruD | 0 | DIRECT |
Eukaryotic DNA topoisomerase I, catalytic core | 0 | DIRECT |
L-rhamnose isomerase | 0 | DIRECT |
FMN-linked oxidoreductases | 0 | DIRECT |
Phosphoglucomutase, first 3 domains | 0 | DIRECT |
Ribose/Galactose isomerase RpiB/AlsB | 0 | DIRECT |
L-fucose isomerase, N-terminal and second domains | 0 | DIRECT |
Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | DIRECT |
Trigger factor ribosome-binding domain | 0 | DIRECT |
TF C-terminus | 0 | DIRECT |
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
DNA gyrase/MutL, N-terminal domain | 0 | DIRECT |
Chalcone isomerase | 0 | DIRECT |
Uronate isomerase-like | 0 | DIRECT |
FKBP immunophilin/proline isomerase | 0 | DIRECT |
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | 0 | DIRECT |
GABA-aminotransferase-like | 0 | DIRECT |
NanE-like | 0 | DIRECT |
Muconalactone isomerase, MLI | 0 | DIRECT |
6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.000000000000354 | DIRECT |
MIF-related | 0.000000000008197 | DIRECT |
Dimeric chorismate mutase | 0.0000000008732 | DIRECT |
Canonical RBD | 0.00000001195 | DIRECT |
Predicted hydrolases Cof | 0.0000000843 | DIRECT |
Peptidyl carrier domain | 0.000006142 | DIRECT |
WW domain | 0.00005875 | DIRECT |
mannose-1-phosphate guanylyl transferase | 0.000172 | DIRECT |
WD40-repeat | 0.000172 | DIRECT |
MAPEG domain | 0.0007041 | DIRECT |
ADC synthase | 0.0008387 | DIRECT |
AraD-like aldolase/epimerase | 0.001559 | INHERITED FROM: L-ribulose-5-phosphate 4-epimerase || Acting on carbohydrates and derivatives || Racemases and epimerases |
Intein (protein splicing domain) | 0.002635 | INHERITED FROM: DNA topoisomerase (ATP-hydrolyzing) || Other isomerases |
Terpenoid cyclase N-terminal domain | 0.009827 | INHERITED FROM: Copalyl diphosphate synthase || Intramolecular lyases || Ent-copalyl diphosphate synthase |
Terpenoid cyclase C-terminal domain | 0.04518 | INHERITED FROM: Copalyl diphosphate synthase || Intramolecular lyases || Ent-copalyl diphosphate synthase |
D-glucarate dehydratase-like | 0.07305 | INHERITED FROM: Intramolecular lyases || Chloromuconate cycloisomerase || Muconate cycloisomerase |
CBS-domain pair | 0.3327 | INHERITED FROM: Arabinose-5-phosphate isomerase |
Glutathione S-transferase (GST), N-terminal domain | 0.5668 | INHERITED FROM: Other intramolecular oxidoreductases || Cis-trans-isomerases || Maleylacetoacetate isomerase |
Glutathione S-transferase (GST), C-terminal domain | 0.6021 | INHERITED FROM: Other intramolecular oxidoreductases || Cis-trans-isomerases || Maleylacetoacetate isomerase |
ROK | 0.6682 | INHERITED FROM: Acting on carbohydrates and derivatives || Racemases and epimerases |
double-SIS domain | 0.8197 | INHERITED FROM: Glucose-6-phosphate isomerase || Mannose-6-phosphate isomerase |
Enolase N-terminal domain-like | 1 | INHERITED FROM: Intramolecular lyases || Chloromuconate cycloisomerase || Muconate cycloisomerase |
Dihydrodipicolinate reductase-like | 1 | INHERITED FROM: Intramolecular lyases || Inositol-3-phosphate synthase |
Cytochrome P450 | 1 | INHERITED FROM: Other intramolecular oxidoreductases || Thromboxane-A synthase |
Ribulose 1,5-bisphosphate carboxylase-oxygenase | 1 | INHERITED FROM: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase || Interconverting keto- and enol- groups |
Class I glutamine amidotransferases (GAT) | 1 | INHERITED FROM: Phosphoribosylanthranilate isomerase |
Acetyl-CoA synthetase-like | 1 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | INHERITED FROM: Serine racemase |
Phosphate binding protein-like | 1 | INHERITED FROM: Chorismate mutase |
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: Intramolecular lyases || Inositol-3-phosphate synthase |
RuBisCo, large subunit, C-terminal domain | 1 | INHERITED FROM: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase || Interconverting keto- and enol- groups |
SCOP term |
FDR (all) |
Annotation (direct or inherited) |
Topoisomerase VI-B subunit middle domain | 0 | Direct |
D-ribose-5-phosphate isomerase (RpiA), catalytic domain | 0 | Direct |
Thi4-like | 0 | Direct |
Tyrosine-dependent oxidoreductases | 0 | Direct |
UDP-N-acetylglucosamine 2-epimerase | 0 | Direct |
AraA N-terminal and middle domain-like | 0 | Direct |
Crotonase-like | 0 | Direct |
Aspartate/glutamate racemase | 0 | Direct |
N-acylglucosamine (NAG) epimerase | 0 | Direct |
HCDH C-domain-like | 0 | Direct |
Retinol binding protein-like | 0 | Direct |
PDI-like | 0 | Direct |
Glucose-6-phosphate isomerase, GPI | 0 | Direct |
Type I phosphomannose isomerase | 0 | Direct |
Prokaryotic DNA topoisomerase I, a C-terminal fragment | 0 | Direct |
DNA gyrase/MutL, second domain | 0 | Direct |
PUA domain | 0 | Direct |
Pseudouridine synthase RsuA N-terminal domain | 0 | Direct |
Alanine racemase | 0 | Direct |
dTDP-sugar isomerase | 0 | Direct |
Diaminopimelate epimerase | 0 | Direct |
Cobalamin (vitamin B12)-binding domain | 0 | Direct |
DNA topoisomerase IV, alpha subunit | 0 | Direct |
Terpene synthases | 0 | Direct |
AraA C-terminal domain-like | 0 | Direct |
Helicase-like "domain" of reverse gyrase | 0 | Direct |
Phosphoglucomutase, C-terminal domain | 0 | Direct |
Pseudouridine synthase II TruB | 0 | Direct |
Triosephosphate isomerase (TIM) | 0 | Direct |
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 0 | Direct |
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain | 0 | Direct |
PTPA-like | 0 | Direct |
DeoB catalytic domain-like | 0 | Direct |
KduI-like | 0 | Direct |
Pseudouridine synthase RsuA/RluD | 0 | Direct |
D-ribulose-5-phosphate 3-epimerase | 0 | Direct |
L-fucose isomerase, C-terminal domain | 0 | Direct |
Tetratricopeptide repeat (TPR) | 0 | Direct |
YiiL-like | 0 | Direct |
Aldose 1-epimerase (mutarotase) | 0 | Direct |
ERP29 C domain-like | 0 | Direct |
IF2B-like | 0 | Direct |
DeoB insert domain-like | 0 | Direct |
Prokaryotic type I DNA topoisomerase | 0 | Direct |
GyrA/ParC C-terminal domain-like | 0 | Direct |
RbsD-like | 0 | Direct |
Cofactor-dependent phosphoglycerate mutase | 0 | Direct |
D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | Direct |
Proline racemase | 0 | Direct |
Cyclophilin (peptidylprolyl isomerase) | 0 | Direct |
Xylose isomerase | 0 | Direct |
Phosphoglucose isomerase, PGI | 0 | Direct |
Hypothetical protein YgbM (EC1530) | 0 | Direct |
IPP isomerase-like | 0 | Direct |
Histidine biosynthesis enzymes | 0 | Direct |
Pseudouridine synthase I TruA | 0 | Direct |
mono-SIS domain | 0 | Direct |
Methylmalonyl-CoA mutase, N-terminal (CoA-binding) domain | 0 | Direct |
Porin chaperone SurA, peptide-binding domain | 0 | Direct |
Tryptophan biosynthesis enzymes | 0 | Direct |
Alanine racemase-like, N-terminal domain | 0 | Direct |
Type II DNA topoisomerase | 0 | Direct |
Kelch motif | 0 | Direct |
tRNA pseudouridine synthase TruD | 0 | Direct |
Eukaryotic DNA topoisomerase I, catalytic core | 0 | Direct |
L-rhamnose isomerase | 0 | Direct |
FMN-linked oxidoreductases | 0 | Direct |
Phosphoglucomutase, first 3 domains | 0 | Direct |
Ribose/Galactose isomerase RpiB/AlsB | 0 | Direct |
L-fucose isomerase, N-terminal and second domains | 0 | Direct |
Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | Direct |
Trigger factor ribosome-binding domain | 0 | Direct |
TF C-terminus | 0 | Direct |
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
DNA gyrase/MutL, N-terminal domain | 0 | Direct |
Chalcone isomerase | 0 | Direct |
Uronate isomerase-like | 0 | Direct |
FKBP immunophilin/proline isomerase | 0 | Direct |
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | 0 | Direct |
GABA-aminotransferase-like | 0 | Direct |
NanE-like | 0 | Direct |
Muconalactone isomerase, MLI | 0 | Direct |
6-phosphogluconate dehydrogenase-like, N-terminal domain | 0.000000000000354 | Direct |
MIF-related | 0.000000000008197 | Direct |
Dimeric chorismate mutase | 0.0000000008732 | Direct |
Canonical RBD | 0.00000001195 | Direct |
Predicted hydrolases Cof | 0.0000000843 | Direct |
Peptidyl carrier domain | 0.000006142 | Direct |
WW domain | 0.00005875 | Direct |
mannose-1-phosphate guanylyl transferase | 0.000172 | Direct |
WD40-repeat | 0.000172 | Direct |
MAPEG domain | 0.0007041 | Direct |
ADC synthase | 0.0008387 | Direct |
AraD-like aldolase/epimerase | 0.001559 | Inherited |
Intein (protein splicing domain) | 0.002635 | Inherited |
Terpenoid cyclase N-terminal domain | 0.009827 | Inherited |
Terpenoid cyclase C-terminal domain | 0.04518 | Inherited |
D-glucarate dehydratase-like | 0.07305 | Inherited |
CBS-domain pair | 0.3327 | Inherited |
Glutathione S-transferase (GST), N-terminal domain | 0.5668 | Inherited |
Glutathione S-transferase (GST), C-terminal domain | 0.6021 | Inherited |
ROK | 0.6682 | Inherited |
double-SIS domain | 0.8197 | Inherited |
Enolase N-terminal domain-like | 1 | Inherited |
Dihydrodipicolinate reductase-like | 1 | Inherited |
Cytochrome P450 | 1 | Inherited |
Ribulose 1,5-bisphosphate carboxylase-oxygenase | 1 | Inherited |
Class I glutamine amidotransferases (GAT) | 1 | Inherited |
Acetyl-CoA synthetase-like | 1 | Inherited |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | Inherited |
Phosphate binding protein-like | 1 | Inherited |
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 1 | Inherited |
RuBisCo, large subunit, C-terminal domain | 1 | Inherited |
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A presence/absence matrix is generated using protein domains and supradomains
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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
FucI/AraA C-terminal domain-like | 0 | DIRECT |
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | DIRECT |
Cobalamin (vitamin B12)-dependent enzymes | 0 | DIRECT |
Acyl-CoA binding protein | 0 | DIRECT |
D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | DIRECT |
TPR-like | 0 | DIRECT |
DNA topoisomerase IV, alpha subunit | 0 | DIRECT |
Cobalamin (vitamin B12)-binding domain | 0 | DIRECT |
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | 0 | DIRECT |
Nudix | 0 | DIRECT |
Diaminopimelate epimerase-like | 0 | DIRECT |
Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
Type II DNA topoisomerase | 0 | DIRECT |
Phosphoglycerate mutase-like | 0 | DIRECT |
NagB/RpiA/CoA transferase-like | 0 | DIRECT |
ERP29 C domain-like | 0 | DIRECT |
Phosphoglucomutase, first 3 domains | 0 | DIRECT |
FMN-linked oxidoreductases | 0 | DIRECT |
GyrA/ParC C-terminal domain-like | 0 | DIRECT |
Alkaline phosphatase-like | 0 | DIRECT |
PTPA-like | 0 | DIRECT |
FKBP-like | 0 | DIRECT |
Triger factor/SurA peptide-binding domain-like | 0 | DIRECT |
DNA topoisomerase I domain | 0 | DIRECT |
PUA domain-like | 0 | DIRECT |
Ribose/Galactose isomerase RpiB/AlsB | 0 | DIRECT |
FucI/AraA N-terminal and middle domains | 0 | DIRECT |
Aspartate/glutamate racemase | 0 | DIRECT |
Dimeric alpha+beta barrel | 0 | DIRECT |
SIS domain | 0 | DIRECT |
PLP-dependent transferases | 0 | DIRECT |
Pseudouridine synthase | 0 | DIRECT |
Chalcone isomerase | 0 | DIRECT |
Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | DIRECT |
Allene oxide cyclase-like | 0 | DIRECT |
Chorismate mutase II | 0 | DIRECT |
DNA breaking-rejoining enzymes | 0 | DIRECT |
DeoB insert domain-like | 0 | DIRECT |
Oxygen-evolving enhancer protein 3, | 0 | DIRECT |
Zinc beta-ribbon | 0 | DIRECT |
RmlC-like cupins | 0 | DIRECT |
Xylose isomerase-like | 0 | DIRECT |
RbsD-like | 0 | DIRECT |
Triosephosphate isomerase (TIM) | 0 | DIRECT |
Trigger factor ribosome-binding domain | 0 | DIRECT |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
Alanine racemase C-terminal domain-like | 0 | DIRECT |
PLP-binding barrel | 0 | DIRECT |
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 0 | DIRECT |
Precorrin-8X methylmutase CbiC/CobH | 0 | DIRECT |
Kelch motif | 0 | DIRECT |
Cyclophilin-like | 0 | DIRECT |
Ribulose-phoshate binding barrel | 0 | DIRECT |
Lipocalins | 0.00000000000003221 | DIRECT |
Tautomerase/MIF | 0.0000000000004084 | DIRECT |
Alpha-L RNA-binding motif | 0.0000000000006881 | DIRECT |
ClpP/crotonase | 0.000000000005401 | DIRECT |
6-phosphogluconate dehydrogenase C-terminal domain-like | 0.00000000002505 | DIRECT |
Thioredoxin-like | 0.000000001702 | DIRECT |
RNA-binding domain, RBD | 0.000001754 | DIRECT |
WW domain | 0.00003839 | DIRECT |
ADC synthase | 0.0004859 | DIRECT |
MAPEG domain-like | 0.0005236 | DIRECT |
Hedgehog/intein (Hint) domain | 0.0005864 | DIRECT |
AraD/HMP-PK domain-like | 0.0008232 | DIRECT |
Homing endonucleases | 0.0009213 | DIRECT |
Terpenoid synthases | 0.003269 | INHERITED FROM: Copalyl diphosphate synthase || Intramolecular lyases || Ent-copalyl diphosphate synthase || Lycopene beta-cyclase |
HSP20-like chaperones | 0.01056 | INHERITED FROM: Other intramolecular oxidoreductases || Prostaglandin-E synthase || Intramolecular oxidoreductases |
Galactose mutarotase-like | 0.01818 | INHERITED FROM: Glucose-6-phosphate 1-epimerase || Aldose 1-epimerase || Acting on carbohydrates and derivatives || Racemases and epimerases |
RING/U-box | 0.02781 | INHERITED FROM: Cis-trans-isomerases || Peptidylprolyl isomerase |
CoA-transferase family III (CaiB/BaiF) | 0.07487 | INHERITED FROM: Alpha-methylacyl-CoA racemase || Acting on other compounds || Racemases and epimerases |
WD40 repeat-like | 0.07913 | INHERITED FROM: Cis-trans-isomerases || Peptidylprolyl isomerase |
Di-copper centre-containing domain | 0.134 | INHERITED FROM: L-dopachrome isomerase || Transposing C==C bonds |
Chondroitin AC/alginate lyase | 0.1454 | INHERITED FROM: Acting on carbohydrates and derivatives || Racemases and epimerases || Chondroitin-glucuronate 5-epimerase |
CBS-domain pair | 0.3168 | INHERITED FROM: Arabinose-5-phosphate isomerase |
ACP-like | 0.3654 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) || Racemases and epimerases || Acting on amino acids and derivatives |
FAH | 0.3997 | INHERITED FROM: Transposing C==C bonds || 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
GST C-terminal domain-like | 0.596 | INHERITED FROM: Other intramolecular oxidoreductases || Cis-trans-isomerases || Maleylacetoacetate isomerase |
Metallo-dependent hydrolases | 0.6279 | INHERITED FROM: Glucuronate isomerase || Interconverting aldoses and ketoses, and related c || Intramolecular oxidoreductases |
NTF2-like | 0.7093 | INHERITED FROM: Steroid Delta-isomerase || Transposing C==C bonds |
Nucleotide-binding domain | 0.7411 | INHERITED FROM: UDP-galactopyranose mutase || Transferring other groups |
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.7628 | INHERITED FROM: Acting on other compounds || Methylmalonyl-CoA epimerase |
EF-hand | 0.7996 | INHERITED FROM: Cis-trans-isomerases || Peptidylprolyl isomerase |
Glycosyl hydrolase domain | 1 | INHERITED FROM: Maltose alpha-D-glucosyltransferase |
Enolase C-terminal domain-like | 1 | INHERITED FROM: L-Ala-D/L-Glu epimerase || Intramolecular lyases || Chloromuconate cycloisomerase || Muconate cycloisomerase |
NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: ADP-glyceromanno-heptose 6-epimerase || Intramolecular lyases || Steroid Delta-isomerase || Acting on carbohydrates and derivatives || 3-hydroxybutyryl-CoA epimerase || Acting on hydroxy acids and derivatives || Transposing C==C bonds || Inositol-3-phosphate synthase || Racemases and epimerases || Dodecenoyl-CoA isomerase || UDP-glucose 4-epimerase |
FAD/NAD(P)-binding domain | 1 | INHERITED FROM: Ribose 1,5-bisphosphate isomerase || Steroid Delta-isomerase || Prolycopene isomerase || Lycopene beta-cyclase |
S13-like H2TH domain | 1 | INHERITED FROM: DNA topoisomerase (ATP-hydrolyzing) || Other isomerases |
UDP-Glycosyltransferase/glycogen phosphorylase | 1 | INHERITED FROM: Acting on carbohydrates and derivatives || UDP-N-acetylglucosamine 2-epimerase |
Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: UDP-arabinopyranose mutase || Mannose-6-phosphate isomerase |
Actin-like ATPase domain | 1 | INHERITED FROM: UDP-N-acetylglucosamine 2-epimerase |
Cytochrome P450 | 1 | INHERITED FROM: Other intramolecular oxidoreductases || 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase || Transferring hydroxy groups || Prostaglandin-I synthase || Thromboxane-A synthase |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | INHERITED FROM: Serine racemase |
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Intramolecular lyases || Inositol-3-phosphate synthase |
Acetyl-CoA synthetase-like | 1 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) |
L-aspartase-like | 1 | INHERITED FROM: Tyrosine 2,3-aminomutase || 3-carboxy-cis,cis-muconate cycloisomerase |
HAD-like | 1 | INHERITED FROM: Beta-phosphoglucomutase || Phosphomannomutase || Phosphotransferases (phosphomutases) |
Enolase N-terminal domain-like | 1 | INHERITED FROM: L-Ala-D/L-Glu epimerase || Intramolecular lyases || Chloromuconate cycloisomerase || Muconate cycloisomerase |
ACT-like | 1 | INHERITED FROM: Chorismate mutase |
Radical SAM enzymes | 1 | INHERITED FROM: Lysine 2,3-aminomutase |
(Trans)glycosidases | 1 | INHERITED FROM: Maltose alpha-D-glucosyltransferase |
RuBisCo, C-terminal domain | 1 | INHERITED FROM: 5.3.2.5 || Interconverting keto- and enol- groups |
Phosphoenolpyruvate/pyruvate domain | 1 | INHERITED FROM: Phosphoenolpyruvate mutase |
Heme-dependent peroxidases | 1 | INHERITED FROM: 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase || Transferring hydroxy groups |
CoA-dependent acyltransferases | 1 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) || Acting on amino acids and derivatives |
Periplasmic binding protein-like II | 1 | INHERITED FROM: Chorismate mutase |
Class I glutamine amidotransferase-like | 1 | INHERITED FROM: Phosphoribosylanthranilate isomerase |
Six-hairpin glycosidases | 1 | INHERITED FROM: N-acylglucosamine 2-epimerase || Acting on carbohydrates and derivatives |
Ribosomal protein S5 domain 2-like | 1 | INHERITED FROM: DNA topoisomerase (ATP-hydrolyzing) || Other isomerases |
FAD-linked reductases, C-terminal domain | 1 | INHERITED FROM: UDP-galactopyranose mutase |
RuBisCO, large subunit, small (N-terminal) domain | 1 | INHERITED FROM: 5.3.2.5 || Interconverting keto- and enol- groups |
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
FucI/AraA C-terminal domain-like | 0 | Direct |
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 0 | Direct |
Cobalamin (vitamin B12)-dependent enzymes | 0 | Direct |
Acyl-CoA binding protein | 0 | Direct |
D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | Direct |
TPR-like | 0 | Direct |
DNA topoisomerase IV, alpha subunit | 0 | Direct |
Cobalamin (vitamin B12)-binding domain | 0 | Direct |
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain | 0 | Direct |
Nudix | 0 | Direct |
Diaminopimelate epimerase-like | 0 | Direct |
Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
Prokaryotic type I DNA topoisomerase | 0 | Direct |
Type II DNA topoisomerase | 0 | Direct |
Phosphoglycerate mutase-like | 0 | Direct |
NagB/RpiA/CoA transferase-like | 0 | Direct |
ERP29 C domain-like | 0 | Direct |
Phosphoglucomutase, first 3 domains | 0 | Direct |
FMN-linked oxidoreductases | 0 | Direct |
GyrA/ParC C-terminal domain-like | 0 | Direct |
Alkaline phosphatase-like | 0 | Direct |
PTPA-like | 0 | Direct |
FKBP-like | 0 | Direct |
Triger factor/SurA peptide-binding domain-like | 0 | Direct |
DNA topoisomerase I domain | 0 | Direct |
PUA domain-like | 0 | Direct |
Ribose/Galactose isomerase RpiB/AlsB | 0 | Direct |
FucI/AraA N-terminal and middle domains | 0 | Direct |
Aspartate/glutamate racemase | 0 | Direct |
Dimeric alpha+beta barrel | 0 | Direct |
SIS domain | 0 | Direct |
PLP-dependent transferases | 0 | Direct |
Pseudouridine synthase | 0 | Direct |
Chalcone isomerase | 0 | Direct |
Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | Direct |
Allene oxide cyclase-like | 0 | Direct |
Chorismate mutase II | 0 | Direct |
DNA breaking-rejoining enzymes | 0 | Direct |
DeoB insert domain-like | 0 | Direct |
Oxygen-evolving enhancer protein 3, | 0 | Direct |
Zinc beta-ribbon | 0 | Direct |
RmlC-like cupins | 0 | Direct |
Xylose isomerase-like | 0 | Direct |
RbsD-like | 0 | Direct |
Triosephosphate isomerase (TIM) | 0 | Direct |
Trigger factor ribosome-binding domain | 0 | Direct |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
Phosphoglucomutase, C-terminal domain | 0 | Direct |
Alanine racemase C-terminal domain-like | 0 | Direct |
PLP-binding barrel | 0 | Direct |
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment | 0 | Direct |
Precorrin-8X methylmutase CbiC/CobH | 0 | Direct |
Kelch motif | 0 | Direct |
Cyclophilin-like | 0 | Direct |
Ribulose-phoshate binding barrel | 0 | Direct |
Lipocalins | 0.00000000000003221 | Direct |
Tautomerase/MIF | 0.0000000000004084 | Direct |
Alpha-L RNA-binding motif | 0.0000000000006881 | Direct |
ClpP/crotonase | 0.000000000005401 | Direct |
6-phosphogluconate dehydrogenase C-terminal domain-like | 0.00000000002505 | Direct |
Thioredoxin-like | 0.000000001702 | Direct |
RNA-binding domain, RBD | 0.000001754 | Direct |
WW domain | 0.00003839 | Direct |
ADC synthase | 0.0004859 | Direct |
MAPEG domain-like | 0.0005236 | Direct |
Hedgehog/intein (Hint) domain | 0.0005864 | Direct |
AraD/HMP-PK domain-like | 0.0008232 | Direct |
Homing endonucleases | 0.0009213 | Direct |
Terpenoid synthases | 0.003269 | Inherited |
HSP20-like chaperones | 0.01056 | Inherited |
Galactose mutarotase-like | 0.01818 | Inherited |
RING/U-box | 0.02781 | Inherited |
CoA-transferase family III (CaiB/BaiF) | 0.07487 | Inherited |
WD40 repeat-like | 0.07913 | Inherited |
Di-copper centre-containing domain | 0.134 | Inherited |
Chondroitin AC/alginate lyase | 0.1454 | Inherited |
CBS-domain pair | 0.3168 | Inherited |
ACP-like | 0.3654 | Inherited |
FAH | 0.3997 | Inherited |
GST C-terminal domain-like | 0.596 | Inherited |
Metallo-dependent hydrolases | 0.6279 | Inherited |
NTF2-like | 0.7093 | Inherited |
Nucleotide-binding domain | 0.7411 | Inherited |
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.7628 | Inherited |
EF-hand | 0.7996 | Inherited |
Glycosyl hydrolase domain | 1 | Inherited |
Enolase C-terminal domain-like | 1 | Inherited |
NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
FAD/NAD(P)-binding domain | 1 | Inherited |
S13-like H2TH domain | 1 | Inherited |
UDP-Glycosyltransferase/glycogen phosphorylase | 1 | Inherited |
Nucleotide-diphospho-sugar transferases | 1 | Inherited |
Actin-like ATPase domain | 1 | Inherited |
Cytochrome P450 | 1 | Inherited |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 1 | Inherited |
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | Inherited |
Acetyl-CoA synthetase-like | 1 | Inherited |
L-aspartase-like | 1 | Inherited |
HAD-like | 1 | Inherited |
Enolase N-terminal domain-like | 1 | Inherited |
ACT-like | 1 | Inherited |
Radical SAM enzymes | 1 | Inherited |
(Trans)glycosidases | 1 | Inherited |
RuBisCo, C-terminal domain | 1 | Inherited |
Phosphoenolpyruvate/pyruvate domain | 1 | Inherited |
Heme-dependent peroxidases | 1 | Inherited |
CoA-dependent acyltransferases | 1 | Inherited |
Periplasmic binding protein-like II | 1 | Inherited |
Class I glutamine amidotransferase-like | 1 | Inherited |
Six-hairpin glycosidases | 1 | Inherited |
Ribosomal protein S5 domain 2-like | 1 | Inherited |
FAD-linked reductases, C-terminal domain | 1 | Inherited |
RuBisCO, large subunit, small (N-terminal) domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55174,55120 55174 - Alpha-L RNA-binding motif 55120 - Pseudouridine synthase | 0 | DIRECT |
51294,56719 51294 - Hedgehog/intein (Hint) domain 56719 - Type II DNA topoisomerase | 0 | DIRECT |
47027,52096 47027 - Acyl-CoA binding protein 52096 - ClpP/crotonase | 0 | DIRECT |
56719,56719 56719 - Type II DNA topoisomerase 56719 - Type II DNA topoisomerase | 0 | DIRECT |
53697,54631 53697 - SIS domain 54631 - CBS-domain pair | 0 | DIRECT |
54534,48452 54534 - FKBP-like 48452 - TPR-like | 0 | DIRECT |
56719,101904 56719 - Type II DNA topoisomerase 101904 - GyrA/ParC C-terminal domain-like | 0 | DIRECT |
52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like | 0 | DIRECT |
54506,54506 54506 - Diaminopimelate epimerase-like 54506 - Diaminopimelate epimerase-like | 0 | DIRECT |
51703,52242 51703 - Cobalamin (vitamin B12)-dependent enzymes 52242 - Cobalamin (vitamin B12)-binding domain | 0 | DIRECT |
48600,51735 48600 - Chorismate mutase II 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
56712,51294 56712 - Prokaryotic type I DNA topoisomerase 51294 - Hedgehog/intein (Hint) domain | 0 | DIRECT |
48600,53850 48600 - Chorismate mutase II 53850 - Periplasmic binding protein-like II | 0 | DIRECT |
54928,50891 54928 - RNA-binding domain, RBD 50891 - Cyclophilin-like | 0 | DIRECT |
52540,56712 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
102735,54534 102735 - Trigger factor ribosome-binding domain 54534 - FKBP-like | 0 | DIRECT |
52833,47933 52833 - Thioredoxin-like 47933 - ERP29 C domain-like | 0 | DIRECT |
55874,56719 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 56719 - Type II DNA topoisomerase | 0 | DIRECT |
55120,88697 55120 - Pseudouridine synthase 88697 - PUA domain-like | 0 | DIRECT |
50729,50891 50729 - PH domain-like 50891 - Cyclophilin-like | 0 | DIRECT |
56719,55608 56719 - Type II DNA topoisomerase 55608 - Homing endonucleases | 0 | DIRECT |
64158,53649 64158 - 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain 53649 - Alkaline phosphatase-like | 0 | DIRECT |
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
55874,46946 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 46946 - S13-like H2TH domain | 0 | DIRECT |
46946,54211 46946 - S13-like H2TH domain 54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
100950,75445 100950 - NagB/RpiA/CoA transferase-like 75445 - D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | DIRECT |
56529,56529 56529 - FAH 56529 - FAH | 0 | DIRECT |
54534,54534 54534 - FKBP-like 54534 - FKBP-like | 0 | DIRECT |
48239,48239 48239 - Terpenoid cyclases/Protein prenyltransferases 48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
56712,57783 56712 - Prokaryotic type I DNA topoisomerase 57783 - Zinc beta-ribbon | 0 | DIRECT |
55869,56349 55869 - DNA topoisomerase I domain 56349 - DNA breaking-rejoining enzymes | 0 | DIRECT |
52096,51735 52096 - ClpP/crotonase 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53743,50443 53743 - FucI/AraA N-terminal and middle domains 50443 - FucI/AraA C-terminal domain-like | 0 | DIRECT |
55874,54211 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
56741,56349 56741 - Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment 56349 - DNA breaking-rejoining enzymes | 0 | DIRECT |
109998,54534 109998 - Triger factor/SurA peptide-binding domain-like 54534 - FKBP-like | 0 | DIRECT |
54534,47473 54534 - FKBP-like 47473 - EF-hand | 0 | DIRECT |
54211,56719 54211 - Ribosomal protein S5 domain 2-like 56719 - Type II DNA topoisomerase | 0 | DIRECT |
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
56349,46596 56349 - DNA breaking-rejoining enzymes 46596 - Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | DIRECT |
143856,53649 143856 - DeoB insert domain-like 53649 - Alkaline phosphatase-like | 0 | DIRECT |
51366,51366 51366 - Ribulose-phoshate binding barrel 51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
55608,56719 55608 - Homing endonucleases 56719 - Type II DNA topoisomerase | 0 | DIRECT |
53681,53681 53681 - Aspartate/glutamate racemase 53681 - Aspartate/glutamate racemase | 0 | DIRECT |
55608,56712 55608 - Homing endonucleases 56712 - Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
57783,57783 57783 - Zinc beta-ribbon 57783 - Zinc beta-ribbon | 0 | DIRECT |
51735,74650 51735 - NAD(P)-binding Rossmann-fold domains 74650 - Galactose mutarotase-like | 0 | DIRECT |
48179,48179 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
54534,109998 54534 - FKBP-like 109998 - Triger factor/SurA peptide-binding domain-like | 0 | DIRECT |
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
51045,54534 51045 - WW domain 54534 - FKBP-like | 0 | DIRECT |
50891,48452 50891 - Cyclophilin-like 48452 - TPR-like | 0 | DIRECT |
53756,53067 53756 - UDP-Glycosyltransferase/glycogen phosphorylase 53067 - Actin-like ATPase domain | 0 | DIRECT |
52317,51366 52317 - Class I glutamine amidotransferase-like 51366 - Ribulose-phoshate binding barrel | 0.00000000000001136 | DIRECT |
51735,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.00000000002384 | DIRECT |
56801,47336 56801 - Acetyl-CoA synthetase-like 47336 - ACP-like | 0.000001134 | DIRECT |
47336,52777 47336 - ACP-like 52777 - CoA-dependent acyltransferases | 0.000004243 | DIRECT |
48179,52096 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 52096 - ClpP/crotonase | 0.00002601 | DIRECT |
53850,55021 53850 - Periplasmic binding protein-like II 55021 - ACT-like | 0.00006854 | DIRECT |
53448,51182 53448 - Nucleotide-diphospho-sugar transferases 51182 - RmlC-like cupins | 0.0001265 | DIRECT |
52777,56801 52777 - CoA-dependent acyltransferases 56801 - Acetyl-CoA synthetase-like | 0.002796 | INHERITED FROM: Racemases and epimerases || Acting on amino acids and derivatives |
48239,48576 48239 - Terpenoid cyclases/Protein prenyltransferases 48576 - Terpenoid synthases | 0.006188 | INHERITED FROM: Copalyl diphosphate synthase || Intramolecular lyases || Ent-copalyl diphosphate synthase |
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0.03814 | INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing) || Racemases and epimerases || Acting on amino acids and derivatives |
51971,54373 51971 - Nucleotide-binding domain 54373 - FAD-linked reductases, C-terminal domain | 0.07001 | INHERITED FROM: UDP-galactopyranose mutase || Intramolecular transferases (mutases) || Transferring other groups |
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like | 0.4868 | INHERITED FROM: Other intramolecular oxidoreductases || Cis-trans-isomerases || Maleylacetoacetate isomerase |
54966,51649 54966 - RuBisCO, large subunit, small (N-terminal) domain 51649 - RuBisCo, C-terminal domain | 1 | INHERITED FROM: 5.3.2.5 || Interconverting keto- and enol- groups |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Other isomerases |
51445,51011 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain | 1 | INHERITED FROM: Maltose alpha-D-glucosyltransferase |
51735,55347 51735 - NAD(P)-binding Rossmann-fold domains 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Intramolecular lyases || Inositol-3-phosphate synthase |
54826,51604 54826 - Enolase N-terminal domain-like 51604 - Enolase C-terminal domain-like | 1 | INHERITED FROM: L-Ala-D/L-Glu epimerase || Intramolecular lyases || Chloromuconate cycloisomerase || Muconate cycloisomerase |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55174,55120 55174 - Alpha-L RNA-binding motif 55120 - Pseudouridine synthase | 0 | Direct |
51294,56719 51294 - Hedgehog/intein (Hint) domain 56719 - Type II DNA topoisomerase | 0 | Direct |
47027,52096 47027 - Acyl-CoA binding protein 52096 - ClpP/crotonase | 0 | Direct |
56719,56719 56719 - Type II DNA topoisomerase 56719 - Type II DNA topoisomerase | 0 | Direct |
53697,54631 53697 - SIS domain 54631 - CBS-domain pair | 0 | Direct |
54534,48452 54534 - FKBP-like 48452 - TPR-like | 0 | Direct |
56719,101904 56719 - Type II DNA topoisomerase 101904 - GyrA/ParC C-terminal domain-like | 0 | Direct |
52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like | 0 | Direct |
54506,54506 54506 - Diaminopimelate epimerase-like 54506 - Diaminopimelate epimerase-like | 0 | Direct |
51703,52242 51703 - Cobalamin (vitamin B12)-dependent enzymes 52242 - Cobalamin (vitamin B12)-binding domain | 0 | Direct |
48600,51735 48600 - Chorismate mutase II 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
56712,51294 56712 - Prokaryotic type I DNA topoisomerase 51294 - Hedgehog/intein (Hint) domain | 0 | Direct |
48600,53850 48600 - Chorismate mutase II 53850 - Periplasmic binding protein-like II | 0 | Direct |
54928,50891 54928 - RNA-binding domain, RBD 50891 - Cyclophilin-like | 0 | Direct |
52540,56712 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase | 0 | Direct |
102735,54534 102735 - Trigger factor ribosome-binding domain 54534 - FKBP-like | 0 | Direct |
52833,47933 52833 - Thioredoxin-like 47933 - ERP29 C domain-like | 0 | Direct |
55874,56719 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 56719 - Type II DNA topoisomerase | 0 | Direct |
55120,88697 55120 - Pseudouridine synthase 88697 - PUA domain-like | 0 | Direct |
50729,50891 50729 - PH domain-like 50891 - Cyclophilin-like | 0 | Direct |
56719,55608 56719 - Type II DNA topoisomerase 55608 - Homing endonucleases | 0 | Direct |
64158,53649 64158 - 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain 53649 - Alkaline phosphatase-like | 0 | Direct |
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
55874,46946 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 46946 - S13-like H2TH domain | 0 | Direct |
46946,54211 46946 - S13-like H2TH domain 54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
100950,75445 100950 - NagB/RpiA/CoA transferase-like 75445 - D-ribose-5-phosphate isomerase (RpiA), lid domain | 0 | Direct |
56529,56529 56529 - FAH 56529 - FAH | 0 | Direct |
54534,54534 54534 - FKBP-like 54534 - FKBP-like | 0 | Direct |
48239,48239 48239 - Terpenoid cyclases/Protein prenyltransferases 48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
56712,57783 56712 - Prokaryotic type I DNA topoisomerase 57783 - Zinc beta-ribbon | 0 | Direct |
55869,56349 55869 - DNA topoisomerase I domain 56349 - DNA breaking-rejoining enzymes | 0 | Direct |
52096,51735 52096 - ClpP/crotonase 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53743,50443 53743 - FucI/AraA N-terminal and middle domains 50443 - FucI/AraA C-terminal domain-like | 0 | Direct |
55874,54211 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
56741,56349 56741 - Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment 56349 - DNA breaking-rejoining enzymes | 0 | Direct |
109998,54534 109998 - Triger factor/SurA peptide-binding domain-like 54534 - FKBP-like | 0 | Direct |
54534,47473 54534 - FKBP-like 47473 - EF-hand | 0 | Direct |
54211,56719 54211 - Ribosomal protein S5 domain 2-like 56719 - Type II DNA topoisomerase | 0 | Direct |
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
56349,46596 56349 - DNA breaking-rejoining enzymes 46596 - Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | Direct |
143856,53649 143856 - DeoB insert domain-like 53649 - Alkaline phosphatase-like | 0 | Direct |
51366,51366 51366 - Ribulose-phoshate binding barrel 51366 - Ribulose-phoshate binding barrel | 0 | Direct |
55608,56719 55608 - Homing endonucleases 56719 - Type II DNA topoisomerase | 0 | Direct |
53681,53681 53681 - Aspartate/glutamate racemase 53681 - Aspartate/glutamate racemase | 0 | Direct |
55608,56712 55608 - Homing endonucleases 56712 - Prokaryotic type I DNA topoisomerase | 0 | Direct |
57783,57783 57783 - Zinc beta-ribbon 57783 - Zinc beta-ribbon | 0 | Direct |
51735,74650 51735 - NAD(P)-binding Rossmann-fold domains 74650 - Galactose mutarotase-like | 0 | Direct |
48179,48179 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
54534,109998 54534 - FKBP-like 109998 - Triger factor/SurA peptide-binding domain-like | 0 | Direct |
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
51045,54534 51045 - WW domain 54534 - FKBP-like | 0 | Direct |
50891,48452 50891 - Cyclophilin-like 48452 - TPR-like | 0 | Direct |
53756,53067 53756 - UDP-Glycosyltransferase/glycogen phosphorylase 53067 - Actin-like ATPase domain | 0 | Direct |
52317,51366 52317 - Class I glutamine amidotransferase-like 51366 - Ribulose-phoshate binding barrel | 0.00000000000001136 | Direct |
51735,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.00000000002384 | Direct |
56801,47336 56801 - Acetyl-CoA synthetase-like 47336 - ACP-like | 0.000001134 | Direct |
47336,52777 47336 - ACP-like 52777 - CoA-dependent acyltransferases | 0.000004243 | Direct |
48179,52096 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 52096 - ClpP/crotonase | 0.00002601 | Direct |
53850,55021 53850 - Periplasmic binding protein-like II 55021 - ACT-like | 0.00006854 | Direct |
53448,51182 53448 - Nucleotide-diphospho-sugar transferases 51182 - RmlC-like cupins | 0.0001265 | Direct |
52777,56801 52777 - CoA-dependent acyltransferases 56801 - Acetyl-CoA synthetase-like | 0.002796 | Inherited |
48239,48576 48239 - Terpenoid cyclases/Protein prenyltransferases 48576 - Terpenoid synthases | 0.006188 | Inherited |
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0.03814 | Inherited |
51971,54373 51971 - Nucleotide-binding domain 54373 - FAD-linked reductases, C-terminal domain | 0.07001 | Inherited |
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like | 0.4868 | Inherited |
54966,51649 54966 - RuBisCO, large subunit, small (N-terminal) domain 51649 - RuBisCo, C-terminal domain | 1 | Inherited |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
51445,51011 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain | 1 | Inherited |
51735,55347 51735 - NAD(P)-binding Rossmann-fold domains 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 1 | Inherited |
54826,51604 54826 - Enolase N-terminal domain-like 51604 - Enolase C-terminal domain-like | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
109998,54534,54534 109998 - Triger factor/SurA peptide-binding domain-like 54534 - FKBP-like 54534 - FKBP-like | 0 | DIRECT |
54534,54534,48452 54534 - FKBP-like 54534 - FKBP-like 48452 - TPR-like | 0 | DIRECT |
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
54534,54534,54534 54534 - FKBP-like 54534 - FKBP-like 54534 - FKBP-like | 0 | DIRECT |
51735,48179,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51294,56719,55608 51294 - Hedgehog/intein (Hint) domain 56719 - Type II DNA topoisomerase 55608 - Homing endonucleases | 0 | DIRECT |
52540,56712,51294 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase 51294 - Hedgehog/intein (Hint) domain | 0 | DIRECT |
102735,54534,109998 102735 - Trigger factor ribosome-binding domain 54534 - FKBP-like 109998 - Triger factor/SurA peptide-binding domain-like | 0 | DIRECT |
54534,54534,47473 54534 - FKBP-like 54534 - FKBP-like 47473 - EF-hand | 0 | DIRECT |
56741,56349,46596 56741 - Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment 56349 - DNA breaking-rejoining enzymes 46596 - Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | DIRECT |
52317,51366,51366 52317 - Class I glutamine amidotransferase-like 51366 - Ribulose-phoshate binding barrel 51366 - Ribulose-phoshate binding barrel | 0 | DIRECT |
48600,53850,55021 48600 - Chorismate mutase II 53850 - Periplasmic binding protein-like II 55021 - ACT-like | 0 | DIRECT |
48600,51735,48179 48600 - Chorismate mutase II 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
52096,51735,48179 52096 - ClpP/crotonase 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
55874,46946,54211 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 46946 - S13-like H2TH domain 54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
52833,52833,47933 52833 - Thioredoxin-like 52833 - Thioredoxin-like 47933 - ERP29 C domain-like | 0 | DIRECT |
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like | 0 | DIRECT |
57783,57783,57783 57783 - Zinc beta-ribbon 57783 - Zinc beta-ribbon 57783 - Zinc beta-ribbon | 0 | DIRECT |
56719,55608,56719 56719 - Type II DNA topoisomerase 55608 - Homing endonucleases 56719 - Type II DNA topoisomerase | 0 | DIRECT |
56712,57783,57783 56712 - Prokaryotic type I DNA topoisomerase 57783 - Zinc beta-ribbon 57783 - Zinc beta-ribbon | 0 | DIRECT |
52540,52540,56712 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase | 0 | DIRECT |
55874,54211,56719 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like 56719 - Type II DNA topoisomerase | 0 | DIRECT |
48239,48239,48576 48239 - Terpenoid cyclases/Protein prenyltransferases 48239 - Terpenoid cyclases/Protein prenyltransferases 48576 - Terpenoid synthases | 0.0000001203 | DIRECT |
56801,47336,52777 56801 - Acetyl-CoA synthetase-like 47336 - ACP-like 52777 - CoA-dependent acyltransferases | 0.0000002145 | DIRECT |
47336,52777,52777 47336 - ACP-like 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0.000004243 | DIRECT |
48179,48179,52096 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 52096 - ClpP/crotonase | 0.00002601 | DIRECT |
52777,52777,56801 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases 56801 - Acetyl-CoA synthetase-like | 0.0001708 | DIRECT |
52777,56801,47336 52777 - CoA-dependent acyltransferases 56801 - Acetyl-CoA synthetase-like 47336 - ACP-like | 0.0003201 | DIRECT |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
109998,54534,54534 109998 - Triger factor/SurA peptide-binding domain-like 54534 - FKBP-like 54534 - FKBP-like | 0 | Direct |
54534,54534,48452 54534 - FKBP-like 54534 - FKBP-like 48452 - TPR-like | 0 | Direct |
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
54534,54534,54534 54534 - FKBP-like 54534 - FKBP-like 54534 - FKBP-like | 0 | Direct |
51735,48179,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51294,56719,55608 51294 - Hedgehog/intein (Hint) domain 56719 - Type II DNA topoisomerase 55608 - Homing endonucleases | 0 | Direct |
52540,56712,51294 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase 51294 - Hedgehog/intein (Hint) domain | 0 | Direct |
102735,54534,109998 102735 - Trigger factor ribosome-binding domain 54534 - FKBP-like 109998 - Triger factor/SurA peptide-binding domain-like | 0 | Direct |
54534,54534,47473 54534 - FKBP-like 54534 - FKBP-like 47473 - EF-hand | 0 | Direct |
56741,56349,46596 56741 - Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment 56349 - DNA breaking-rejoining enzymes 46596 - Eukaryotic DNA topoisomerase I, dispensable insert domain | 0 | Direct |
52317,51366,51366 52317 - Class I glutamine amidotransferase-like 51366 - Ribulose-phoshate binding barrel 51366 - Ribulose-phoshate binding barrel | 0 | Direct |
48600,53850,55021 48600 - Chorismate mutase II 53850 - Periplasmic binding protein-like II 55021 - ACT-like | 0 | Direct |
48600,51735,48179 48600 - Chorismate mutase II 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
52096,51735,48179 52096 - ClpP/crotonase 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
55874,46946,54211 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 46946 - S13-like H2TH domain 54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
52833,52833,47933 52833 - Thioredoxin-like 52833 - Thioredoxin-like 47933 - ERP29 C domain-like | 0 | Direct |
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like | 0 | Direct |
57783,57783,57783 57783 - Zinc beta-ribbon 57783 - Zinc beta-ribbon 57783 - Zinc beta-ribbon | 0 | Direct |
56719,55608,56719 56719 - Type II DNA topoisomerase 55608 - Homing endonucleases 56719 - Type II DNA topoisomerase | 0 | Direct |
56712,57783,57783 56712 - Prokaryotic type I DNA topoisomerase 57783 - Zinc beta-ribbon 57783 - Zinc beta-ribbon | 0 | Direct |
52540,52540,56712 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase | 0 | Direct |
55874,54211,56719 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like 56719 - Type II DNA topoisomerase | 0 | Direct |
48239,48239,48576 48239 - Terpenoid cyclases/Protein prenyltransferases 48239 - Terpenoid cyclases/Protein prenyltransferases 48576 - Terpenoid synthases | 0.0000001203 | Direct |
56801,47336,52777 56801 - Acetyl-CoA synthetase-like 47336 - ACP-like 52777 - CoA-dependent acyltransferases | 0.0000002145 | Direct |
47336,52777,52777 47336 - ACP-like 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0.000004243 | Direct |
48179,48179,52096 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 52096 - ClpP/crotonase | 0.00002601 | Direct |
52777,52777,56801 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases 56801 - Acetyl-CoA synthetase-like | 0.0001708 | Direct |
52777,56801,47336 52777 - CoA-dependent acyltransferases 56801 - Acetyl-CoA synthetase-like 47336 - ACP-like | 0.0003201 | Direct |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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