SUPERFAMILY 1.75 HMM library and genome assignments server

Domain assignment for ENSP00000260227 from Homo sapiens 76_38

Domain architecture


Domain assignment details

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Strong hits

Sequence:  ENSP00000260227
Domain Number 1 Region: 97-261
Classification Level Classification E-value
Superfamily Metalloproteases ("zincins"), catalytic domain 4.89e-56
Family Matrix metalloproteases, catalytic domain 5.08e-08
Further Details:      
 
Domain Number 2 Region: 23-92
Classification Level Classification E-value
Superfamily PGBD-like 3.92e-21
Family MMP N-terminal domain 0.0011
Further Details:      
 

Gene Ontology term assignment details

The top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by dcGO Predictor

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Molecular Function IC (bits) H-Score
metallopeptidase activity 1.956 173.69
endopeptidase activity 1.539 149.07
zinc ion binding 1.658 43.61
integrin binding 1.752 17.74
growth factor receptor binding 1.996 15.08
cytokine receptor binding 2.034 15.08
enzyme activator activity 1.402 14.46
amide binding 1.71 13.19
collagen binding 1.837 10.43
protein complex binding 1.49 8.1
Cellular Component IC (bits) H-Score
brush border 1.481 22.53
secretory granule 1.827 10.56
neuron projection terminus 2.132 9.5
lysosomal membrane 2.005 8.2
trans-Golgi network 1.798 8.02
clathrin-coated vesicle 1.877 7.82
coated vesicle 1.745 7.82
dendrite 1.548 7.12
synapse part 1.513 5.74
DNA-directed RNA polymerase complex 2.005 5.58

Protein sequence

External link(s) Protein: ENSP00000260227   Gene: ENSG00000137673   Transcript: ENST00000260227
Sequence length 267
Comment pep:known chromosome:GRCh38:11:102520508:102530753:-1 gene:ENSG00000137673 transcript:ENST00000260227 gene_biotype:protein_coding transcript_biotype:protein_coding
Sequence
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLK
EMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDL
PHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAF
APGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGD
PQNFKLSQDDIKGIQKLYGKRSNSRKK
Download sequence
Identical sequences P09237
ENSP00000260227 9606.ENSP00000260227 ENSP00000260227 gi|4505219|ref|NP_002414.1|

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