SUPERFAMILY 1.75 HMM library and genome assignments server

Domain assignment for ENSP00000300762 from Homo sapiens 76_38

Domain architecture


Domain assignment details

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Strong hits

Sequence:  ENSP00000300762
Domain Number 1 Region: 94-254
Classification Level Classification E-value
Superfamily Metalloproteases ("zincins"), catalytic domain 7.09e-56
Family Matrix metalloproteases, catalytic domain 0.0000181
Further Details:      
 
Weak hits

Sequence:  ENSP00000300762
Domain Number - Region: 20-86
Classification Level Classification E-value
Superfamily PGBD-like 0.000451
Family MMP N-terminal domain 0.012
Further Details:      
 

Gene Ontology term assignment details

The top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by dcGO Predictor

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Cellular Component IC (bits) H-Score
brush border 1.477 22.56
secretory granule 1.818 10.6
neuron projection terminus 2.132 10.38
lysosomal membrane 1.986 8.14
trans-Golgi network 1.793 7.96
lytic vacuole 1.571 7.43
vacuolar part 1.621 7.24
dendrite 1.585 7.21
transferase complex 1.423 5.58
nucleoplasm part 1.496 5.58
Molecular Function IC (bits) H-Score
endopeptidase activity 1.536 148.91
metalloendopeptidase activity 2.043 148.91
zinc ion binding 1.65 43.49
integrin binding 1.779 17.72
growth factor receptor binding 1.998 15.09
cytokine receptor binding 2.036 15.09
enzyme activator activity 1.376 14.48
amide binding 1.716 13.08
cell adhesion molecule binding 1.514 11.59
collagen binding 1.844 5.54

Protein sequence

External link(s) Protein: ENSP00000300762   Gene: ENSG00000167346   Transcript: ENST00000300762
Sequence length 261
Comment pep:known chromosome:GRCh38:11:4988194:4992427:1 gene:ENSG00000167346 transcript:ENST00000300762 gene_biotype:protein_coding transcript_biotype:protein_coding
Sequence
MQLVILRVTIFLPWCFAVPVPPAADHKGWDFVEGYFHQFFLTKKESPLLTQETQTQLLQQ
FHRNGTDLLDMQMHALLHQPHCGVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAV
KDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSG
NPGVVHFDKNEHWSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQL
SADDIQRIQHLYGEKCSSDIP
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Identical sequences Q9NRE1
9606.ENSP00000300762 ENSP00000300762 gi|73808266|ref|NP_068573.2| GO.101538 MPIB-421 ENSP00000300762 ENSP00000369753

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