SUPERFAMILY 1.75 HMM library and genome assignments server

Domain assignment for ENSP00000322788 from Homo sapiens 76_38

Domain architecture


Domain assignment details

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Strong hits

Sequence:  ENSP00000322788
Domain Number 1 Region: 272-466
Classification Level Classification E-value
Superfamily Hemopexin-like domain 1.44e-71
Family Hemopexin-like domain 0.00000000194
Further Details:      
 
Domain Number 2 Region: 103-264
Classification Level Classification E-value
Superfamily Metalloproteases ("zincins"), catalytic domain 2.75e-58
Family Matrix metalloproteases, catalytic domain 0.0000000719
Further Details:      
 
Domain Number 3 Region: 21-97
Classification Level Classification E-value
Superfamily PGBD-like 3.3e-21
Family MMP N-terminal domain 0.0000402
Further Details:      
 

Gene Ontology term assignment details

The top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by dcGO Predictor

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Molecular Function IC (bits) H-Score
endopeptidase activity 1.536 148.91
metalloendopeptidase activity 2.043 148.91
zinc ion binding 1.65 43.49
integrin binding 1.779 17.72
growth factor receptor binding 1.998 15.09
cytokine receptor binding 2.036 15.09
enzyme activator activity 1.376 14.48
amide binding 1.716 13.08
cell adhesion molecule binding 1.514 11.59
collagen binding 1.844 5.54
Cellular Component IC (bits) H-Score
brush border 1.477 22.56
Golgi lumen 2.24 12.25
secretory granule 1.818 10.6
neuron projection terminus 2.132 10.38
lysosomal membrane 1.986 8.14
trans-Golgi network 1.793 7.96
lytic vacuole 1.571 7.43
vacuolar part 1.621 7.24
dendrite 1.585 7.21
transferase complex 1.423 5.58

Protein sequence

External link(s) Protein: ENSP00000322788   Gene: ENSG00000196611   Transcript: ENST00000315274
Sequence length 469
Comment pep:known chromosome:GRCh38:11:102789920:102798160:-1 gene:ENSG00000196611 transcript:ENST00000315274 gene_biotype:protein_coding transcript_biotype:protein_coding
Sequence
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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Identical sequences P03956
ENSP00000322788 MPIB-401 gi|4505215|ref|NP_002412.1| ENSP00000322788 9606.ENSP00000322788

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