SUPERFAMILY 1.75 HMM library and genome assignments server

Domain assignment for ENSP00000441485 from Homo sapiens 76_38

Domain architecture


Domain assignment details

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Strong hits

Sequence:  ENSP00000441485
Domain Number 1 Region: 24-96
Classification Level Classification E-value
Superfamily PGBD-like 3.92e-21
Family MMP N-terminal domain 0.00012
Further Details:      
 
Domain Number 2 Region: 102-178
Classification Level Classification E-value
Superfamily Metalloproteases ("zincins"), catalytic domain 5.87e-20
Family Matrix metalloproteases, catalytic domain 0.0000207
Further Details:      
 

Gene Ontology term assignment details

The top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by dcGO Predictor

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Cellular Component IC (bits) H-Score
brush border 1.477 22.56
secretory granule 1.818 10.6
neuron projection terminus 2.132 10.38
lysosomal membrane 1.986 8.14
trans-Golgi network 1.793 7.96
lytic vacuole 1.571 7.43
vacuolar part 1.621 7.24
dendrite 1.585 7.21
transferase complex 1.423 5.58
nucleoplasm part 1.496 5.58
Molecular Function IC (bits) H-Score
endopeptidase activity 1.536 148.91
metalloendopeptidase activity 2.043 148.91
zinc ion binding 1.65 43.49
integrin binding 1.779 17.72
growth factor receptor binding 1.998 15.09
cytokine receptor binding 2.036 15.09
enzyme activator activity 1.376 14.48
amide binding 1.716 13.08
cell adhesion molecule binding 1.514 11.59
collagen binding 1.844 5.54

Protein sequence

External link(s) Protein: ENSP00000441485   Gene: ENSG00000166670   Transcript: ENST00000539681
Sequence length 181
Comment pep:novel chromosome:GRCh38:11:102778669:102780628:-1 gene:ENSG00000166670 transcript:ENST00000539681 gene_biotype:protein_coding transcript_biotype:protein_coding
Sequence
MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV
KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY
TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKGHSLAHAYPPGPGLY
G
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Identical sequences F5GYX7
ENSP00000441485

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