SUPERFAMILY 1.75 HMM library and genome assignments server

Domain assignment for ENSP00000441485 from Homo sapiens 76_38

Domain architecture


Domain assignment details

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Strong hits

Sequence:  ENSP00000441485
Domain Number 1 Region: 24-96
Classification Level Classification E-value
Superfamily PGBD-like 3.92e-21
Family MMP N-terminal domain 0.00012
Further Details:      
 
Domain Number 2 Region: 102-178
Classification Level Classification E-value
Superfamily Metalloproteases ("zincins"), catalytic domain 5.87e-20
Family Matrix metalloproteases, catalytic domain 2.07e-05
Further Details:      
 

Gene Ontology term assignment details

The top 10 most specific Gene Ontology terms for each namespace assigned to this domain architecture as determined by dcGO Predictor

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Molecular Function IC (bits) H-Score
metallopeptidase activity 1.956 173.69
endopeptidase activity 1.539 149.07
zinc ion binding 1.658 43.61
integrin binding 1.752 17.74
cytokine receptor binding 2.034 15.08
growth factor receptor binding 1.996 15.08
enzyme activator activity 1.402 14.46
amide binding 1.71 13.19
collagen binding 1.837 10.43
protein complex binding 1.49 8.1
Cellular Component IC (bits) H-Score
brush border 1.481 22.53
secretory granule 1.827 10.56
neuron projection terminus 2.132 9.5
lysosomal membrane 2.005 8.2
trans-Golgi network 1.798 8.02
coated vesicle 1.745 7.82
clathrin-coated vesicle 1.877 7.82
dendrite 1.548 7.12
synapse part 1.513 5.74
nucleoplasm part 1.418 5.58

Protein sequence

External link(s) Protein: ENSP00000441485   Gene: ENSG00000166670   Transcript: ENST00000539681
Sequence length 181
Comment pep:novel chromosome:GRCh38:11:102778669:102780628:-1 gene:ENSG00000166670 transcript:ENST00000539681 gene_biotype:protein_coding transcript_biotype:protein_coding
Sequence
MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV
KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY
TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKGHSLAHAYPPGPGLY
G
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Identical sequences F5GYX7
ENSP00000441485

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