SUPERFAMILY 1.75 HMM library and genome assignments server

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Biological Process (BP): cytoskeleton organization

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Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   biological_process [GO:0008150] <24>
+ + + 3:   cellular component organization or biogenesis [GO:0071840] <2>(123|122) (647|619|358)
+ + + 3:   cellular process [GO:0009987] <21>(372|486) (1162|1371|744)
+ + 2:   cellular component organization [GO:0016043] <33>(113|104) (617|594|349)
+ 1:   organelle organization [GO:0006996] <27>(69|66) (402|354|191)
0:   cytoskeleton organization [GO:0007010] <10>(25|24) (145|138|83)
- 1:   microtubule cytoskeleton organization [GO:0000226] <19>(5|5) (74|50|14)
- 1:   actin cytoskeleton organization [GO:0030036] <12>(16|15) (95|98|67)
- 1:   establishment or maintenance of cytoskeleton polarity [GO:0030952] <4>(1|1) (11|2|0)
- 1:   cortical cytoskeleton organization [GO:0030865] <3>(2|1) (19|9|4)
- 1:   intermediate filament cytoskeleton organization [GO:0045104] <3>(1|1) (7|4|0)
- 1:   septin cytoskeleton organization [GO:0032185] <1>(0|0) (5|0|0)
- 1:   cytoskeletal anchoring at nuclear membrane [GO:0090286](0|0) (1|1|1)
- 1:   cytoskeletal anchoring at plasma membrane [GO:0007016](0|0) (11|7|7)
- 1:   cytoskeletal rearrangement involved in phagocytosis, engulfment [GO:0060097](0|0) (0|0|0)
- 1:   microtubule cytoskeleton attachment to nuclear envelope [GO:1990933](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Actin depolymerizing proteins00Direct
Annexin0.000038890.0002166Direct
Arp2/3 complex 16 kDa subunit ARPC50.0000000000058640.0000000005949Direct
Arp2/3 complex 21 kDa subunit ARPC30.00000000025680.00000002443Direct
Arp2/3 complex subunits0.0000000018530.0000000000001109Direct
Core binding factor beta, CBF0.000000000012950.00000000000009208Direct
Cu,Zn superoxide dismutase-like0.0000000000020080.000003345Direct
EF-hand00Direct
Immunoglobulin0.00028970.00000001064Direct
Inhibitor of apoptosis (IAP) repeat0.00000000000026050.0001785Direct
Interleukin 8-like chemokines0.00000000000031540.00000000001836Direct
Mss4-like0.00000021610.0001042Direct
Prefoldin0.000029350.0000004361Direct
Profilin (actin-binding protein)00Direct
RNase A-like00.000000000000344Direct
SRF-like0.0000030480.0000000000001587Direct
Stathmin0.00000026290.00004502Direct
Subunits of heterodimeric actin filament capping protein Capz0.0000000000000031440.0000000000003232Direct
Tropomyosin0.00000021690.0000000000002904Direct
Protein kinase-like (PK-like)0.020090Inherited
ARM repeat0.037960.01575Inherited
Troponin coil-coiled subunits0.0029070Inherited
Aquaporin-like0.00031450.1057Inherited
P-loop containing nucleoside triphosphate hydrolases0.57091Inherited
Bet v1-like0.17310.09668Inherited


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Family

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
AD-003 protein-like0.000042080.00009949Direct
Annexin0.000041540.0004591Direct
Arp2/3 complex 16 kDa subunit ARPC50.000000000012150.000000001085Direct
Arp2/3 complex 21 kDa subunit ARPC30.00000000053790.00000004407Direct
Arp2/3 complex subunits0.0000000030830.0000000000003389Direct
Calmodulin-like0.0000000000000022720.00000007176Direct
Capz beta-1 subunit00.000000000000008864Direct
Cofilin-like00.0000000000002017Direct
Core binding factor beta, CBF0.00000000002680.0000000000002348Direct
Cu,Zn superoxide dismutase-like0.0000000000073920.000005554Direct
Inhibitor of apoptosis (IAP) repeat0.0000000000006760.0002626Direct
Interleukin 8-like chemokines0.0000000000019650.0000000001401Direct
p25-alpha00.00000000000000307Direct
Prefoldin0.000031420.000001271Direct
Profilin (actin-binding protein)00Direct
Ribonuclease A-like00.000000000001581Direct
SelR domain0.000000000000033180.00000000003104Direct
SRF-like0.0000018710.000000000001656Direct
Stathmin0.00000043970.00006607Direct
Tropomyosin0.00000068150.00000000000172Direct
Protein kinases, catalytic subunit0.018640Inherited
Troponin I0.0039020.003864Inherited
Aquaporin-like0.00065720.144Inherited
G proteins0.45441Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
GAS2 domain-like0Direct
Plakin repeat0Direct
Troponin coil-coiled subunits0Direct
SH3-domain0Direct
Protein kinase-like (PK-like)0Direct
PH domain-like0Direct
Polo-box domain0Direct
Calponin-homology domain, CH-domain0Direct
Myosin rod fragments0Direct
Profilin (actin-binding protein)0Direct
PDZ domain-like0Direct
Calpain large subunit, middle domain (domain III)0Direct
EF-hand0Direct
Intermediate filament protein, coiled coil region0Direct
Spectrin repeat0Direct
Actin depolymerizing proteins0Direct
Formin homology 2 domain (FH2 domain)0.000000000000001898Direct
GTPase activation domain, GAP0.000000000000002832Direct
DBL homology domain (DH-domain)0.000000000000009141Direct
Second domain of FERM0.00000000000001622Direct
alpha-catenin/vinculin-like0.00000000000001797Direct
Core binding factor beta, CBF0.00000000000004892Direct
Arp2/3 complex subunits0.00000000000005898Direct
SRF-like0.00000000000008482Direct
Tropomyosin0.000000000000156Direct
Subunits of heterodimeric actin filament capping protein Capz0.0000000000001739Direct
Actin-crosslinking proteins0.0000000000001763Direct
RNase A-like0.0000000000001852Direct
A middle domain of Talin 10.0000000000002732Direct
Cap-Gly domain0.0000000000007802Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0.0000000000013Direct
Interleukin 8-like chemokines0.00000000001038Direct
Cysteine-rich domain0.00000000003064Direct
FAT domain of focal adhesion kinase0.00000000003323Direct
Arp2/3 complex 16 kDa subunit ARPC50.0000000003469Direct
Immunoglobulin0.000000006437Direct
Arp2/3 complex 21 kDa subunit ARPC30.00000001495Direct
Glucocorticoid receptor-like (DNA-binding domain)0.00000002863Direct
Tubulin C-terminal domain-like0.00000008316Direct
Fibronectin type III0.0000001518Direct
Prefoldin0.0000002757Direct
I/LWEQ domain0.0000002765Direct
VHP, Villin headpiece domain0.0000006155Direct
Regulator of G-protein signaling, RGS0.0000007153Direct
Cu,Zn superoxide dismutase-like0.000002175Direct
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain0.000003816Direct
Composite domain of metallo-dependent hydrolases0.000005006Direct
Rap/Ran-GAP0.000009525Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0.00001348Direct
G protein-binding domain0.00001382Direct
Tubulin nucleotide-binding domain-like0.00001441Direct
PRC-barrel domain0.00001703Direct
BAR/IMD domain-like0.00001725Direct
(Phosphotyrosine protein) phosphatases II0.00001753Direct
Moesin tail domain0.00001828Direct
Stathmin0.00003038Direct
FF domain0.00004693Direct
CalX-like0.00006911Direct
DEATH domain0.00007029Direct
Mss4-like0.00007127Direct
Ubiquitin-like0.00007707Direct
Integrin beta tail domain0.0001138Direct
Inhibitor of apoptosis (IAP) repeat0.0001232Direct
Annexin0.0001498Direct
N-terminal coiled coil domain from apc0.000243Direct
Tumor suppressor gene product Apc0.000243Direct
RGC domain-like0.0003437Direct
Cullin homology domain0.0003518Direct
C-terminal domain of adenylylcyclase associated protein0.0003653Direct
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain0.0003653Direct
N-terminal domain of adenylylcyclase associated protein, CAP0.0003653Direct
EB1 dimerisation domain-like0.0003653Direct
KA1-like0.0004993Direct
P-loop containing nucleoside triphosphate hydrolases1Inherited
Quinoprotein alcohol dehydrogenase-like0.4089Inherited
FYSH domain0.4378Inherited
Hypothetical protein AF0491, middle domain0.4378Inherited
SET domain1Inherited
FYVE/PHD zinc finger1Inherited
POZ domain0.008529Inherited
Transducin (alpha subunit), insertion domain0.00925Inherited
Ankyrin repeat0.001277Inherited
SMAD/FHA domain0.3714Inherited
Plexin repeat0.09257Inherited
Cytokine0.2551Inherited
Tudor/PWWP/MBT1Inherited
ARM repeat0.01184Inherited
Cysteine proteinases0.8653Inherited
Voltage-gated potassium channels1Inherited
Cadherin-like0.01009Inherited
WW domain0.8062Inherited
Phospholipase D/nuclease0.8995Inherited
RNI-like0.5358Inherited
Actin-like ATPase domain0.2016Inherited
EGF/Laminin0.3018Inherited
vWA-like1Inherited
Integrin domains0.009369Inherited
CAD & PB1 domains0.09937Inherited
HSP20-like chaperones0.004396Inherited
TPR-like1Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.6313Inherited
Outer arm dynein light chain 10.7566Inherited
"Winged helix" DNA-binding domain1Inherited
Tricorn protease domain 20.3935Inherited
Galactose oxidase, central domain0.04246Inherited
Galactose-binding domain-like0.6307Inherited
Calcium ATPase, transduction domain A0.9424Inherited
Calcium ATPase, transmembrane domain M0.974Inherited
Hook domain0.03865Inherited
WD40 repeat-like1Inherited
The spindle assembly checkpoint protein mad21Inherited
Geminin coiled-coil domain0.006408Inherited
E2F-DP heterodimerization region0.1408Inherited
DUSP-like0.05936Inherited
Nucleoplasmin-like core domain0.03068Inherited
Aquaporin-like0.08386Inherited
BRCT domain1Inherited
Bet v1-like0.07657Inherited
Eferin C-derminal domain-like0.003733Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.001512Inherited
ENTH/VHS domain0.114Inherited
L27 domain0.002298Inherited
Myosin S1 fragment, N-terminal domain0.003733Inherited
Nitrous oxide reductase, N-terminal domain0.001001Inherited
SH2 domain0.002211Inherited
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0.3389Inherited
Sec7 domain0.0559Inherited
FAD/NAD(P)-binding domain1Inherited
SAICAR synthase-like0.001448Inherited
Phospholipase A2, PLA20.01217Inherited
alpha/beta-Hydrolases1Inherited
SAM/Pointed domain0.7684Inherited
Metallo-dependent hydrolases0.02591Inherited
E set domains0.5044Inherited
C-terminal, gelsolin-like domain of Sec23/240.3215Inherited
RUN domain-like0.1253Inherited
Bcl-2 inhibitors of programmed cell death1Inherited
RING/U-box1Inherited
MIT domain0.126Inherited
HIT/MYND zinc finger-like0.105Inherited
Doublecortin (DC)0.0154Inherited
Glutathione synthetase ATP-binding domain-like0.264Inherited
Cullin repeat-like0.02423Inherited
Ran binding protein zinc finger-like0.09937Inherited
RNA-binding domain, RBD1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47473,143575
  • 47473 - EF-hand
  • 143575 - GAS2 domain-like
  • 0Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    48097,57889
  • 48097 - Regulator of G-protein signaling, RGS
  • 57889 - Cysteine-rich domain
  • 0Direct
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0Direct
    51905,47576
  • 51905 - FAD/NAD(P)-binding domain
  • 47576 - Calponin-homology domain, CH-domain
  • 0Direct
    47576,143575
  • 47576 - Calponin-homology domain, CH-domain
  • 143575 - GAS2 domain-like
  • 0Direct
    103652,50729
  • 103652 - G protein-binding domain
  • 50729 - PH domain-like
  • 0Direct
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    48371,49785
  • 48371 - ARM repeat
  • 49785 - Galactose-binding domain-like
  • 0Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    49265,56112
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    75399,46966
  • 75399 - Plakin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    56112,48726
  • 56112 - Protein kinase-like (PK-like)
  • 48726 - Immunoglobulin
  • 0Direct
    46966,47473
  • 46966 - Spectrin repeat
  • 47473 - EF-hand
  • 0Direct
    81995,54236
  • 81995 - beta-sandwich domain of Sec23/24
  • 54236 - Ubiquitin-like
  • 0Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.000000000000003737Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.000000000000003737Direct
    48403,48452
  • 48403 - Ankyrin repeat
  • 48452 - TPR-like
  • 0.00000000000000466Direct
    50405,50405
  • 50405 - Actin-crosslinking proteins
  • 50405 - Actin-crosslinking proteins
  • 0.000000000000005554Direct
    55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.000000000000006464Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.00000000000003527Direct
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.0000000000000421Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.00000000000004381Direct
    56112,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 0.00000000000004892Direct
    47576,46966
  • 47576 - Calponin-homology domain, CH-domain
  • 46966 - Spectrin repeat
  • 0.00000000000008979Direct
    109880,109885
  • 109880 - A middle domain of Talin 1
  • 109885 - I/LWEQ domain
  • 0.0000000000002732Direct
    109885,109885
  • 109885 - I/LWEQ domain
  • 109885 - I/LWEQ domain
  • 0.000000000001163Direct
    90257,57997
  • 90257 - Myosin rod fragments
  • 57997 - Tropomyosin
  • 0.000000000001163Direct
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.000000000001612Direct
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.000000000005083Direct
    81324,51735
  • 81324 - Voltage-gated potassium channels
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.00000000001836Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.00000000006079Direct
    54236,49879
  • 54236 - Ubiquitin-like
  • 49879 - SMAD/FHA domain
  • 0.0000000001414Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0.0000000002688Direct
    48371,101447
  • 48371 - ARM repeat
  • 101447 - Formin homology 2 domain (FH2 domain)
  • 0.0000000004861Direct
    63748,48371
  • 63748 - Tudor/PWWP/MBT
  • 48371 - ARM repeat
  • 0.0000000006001Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0.000000001085Direct
    47220,109885
  • 47220 - alpha-catenin/vinculin-like
  • 109885 - I/LWEQ domain
  • 0.000000002942Direct
    69645,69645
  • 69645 - Arp2/3 complex subunits
  • 69645 - Arp2/3 complex subunits
  • 0.000000009073Direct
    48350,55961
  • 48350 - GTPase activation domain, GAP
  • 55961 - Bet v1-like
  • 0.00000001697Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0.00000003438Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00000007156Direct
    48425,50729
  • 48425 - Sec7 domain
  • 50729 - PH domain-like
  • 0.00000009392Direct
    56112,54236
  • 56112 - Protein kinase-like (PK-like)
  • 54236 - Ubiquitin-like
  • 0.0000001211Direct
    56112,90257
  • 56112 - Protein kinase-like (PK-like)
  • 90257 - Myosin rod fragments
  • 0.0000001211Direct
    109885,47220
  • 109885 - I/LWEQ domain
  • 47220 - alpha-catenin/vinculin-like
  • 0.0000001211Direct
    55753,82754
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.0000001395Direct
    82754,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 0.0000001395Direct
    143791,143791
  • 143791 - DUSP-like
  • 143791 - DUSP-like
  • 0.0000002447Direct
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.0000002478Direct
    54001,143791
  • 54001 - Cysteine proteinases
  • 143791 - DUSP-like
  • 0.0000003706Direct
    48403,49265
  • 48403 - Ankyrin repeat
  • 49265 - Fibronectin type III
  • 0.0000003881Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0.0000007762Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.000000971Direct
    47576,57716
  • 47576 - Calponin-homology domain, CH-domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.000002023Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.000003661Direct
    48350,50044
  • 48350 - GTPase activation domain, GAP
  • 50044 - SH3-domain
  • 0.000003675Direct
    50729,69322
  • 50729 - PH domain-like
  • 69322 - Tricorn protease domain 2
  • 0.000003721Direct
    109925,50978
  • 109925 - Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain
  • 50978 - WD40 repeat-like
  • 0.000003816Direct
    74924,52058
  • 74924 - Cap-Gly domain
  • 52058 - L domain-like
  • 0.000003816Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.000005508Direct
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.000007912Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0.0000093Direct
    46966,50044
  • 46966 - Spectrin repeat
  • 50044 - SH3-domain
  • 0.000009828Direct
    117281,50965
  • 117281 - Kelch motif
  • 50965 - Galactose oxidase, central domain
  • 0.00001079Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00001292Direct
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.00001703Direct
    50974,50978
  • 50974 - Nitrous oxide reductase, N-terminal domain
  • 50978 - WD40 repeat-like
  • 0.00002231Direct
    49758,49562
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.00002231Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0.00003048Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.00003568Direct
    49758,49758
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.00007142Direct
    57997,90257
  • 57997 - Tropomyosin
  • 90257 - Myosin rod fragments
  • 0.00007142Direct
    50729,46785
  • 50729 - PH domain-like
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0001131Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.0001429Direct
    54277,50156
  • 54277 - CAD & PB1 domains
  • 50156 - PDZ domain-like
  • 0.0001513Direct
    57196,56496
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.0001694Direct
    56496,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0001694Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.0001794Direct
    57997,57997
  • 57997 - Tropomyosin
  • 57997 - Tropomyosin
  • 0.000243Direct
    50044,46966
  • 50044 - SH3-domain
  • 46966 - Spectrin repeat
  • 0.0005229Direct
    48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0.0005229Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0005663Direct
    54236,74924
  • 54236 - Ubiquitin-like
  • 74924 - Cap-Gly domain
  • 0.0007617Direct
    48452,48371
  • 48452 - TPR-like
  • 48371 - ARM repeat
  • 0.0007617Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0009033Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.0009117Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.5694Inherited
    50998,50978
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 50978 - WD40 repeat-like
  • 0.06834Inherited
    50978,50998
  • 50978 - WD40 repeat-like
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 0.02081Inherited
    89895,109728
  • 89895 - FYSH domain
  • 109728 - Hypothetical protein AF0491, middle domain
  • 0.4378Inherited
    47576,140612
  • 47576 - Calponin-homology domain, CH-domain
  • 140612 - EB1 dimerisation domain-like
  • 0.001009Inherited
    82199,48452
  • 82199 - SET domain
  • 48452 - TPR-like
  • 0.02081Inherited
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.01538Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.03068Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.008963Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.1702Inherited
    51045,47473
  • 51045 - WW domain
  • 47473 - EF-hand
  • 0.002778Inherited
    46966,51045
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 0.007591Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.05381Inherited
    50729,52799
  • 50729 - PH domain-like
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.002474Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.08729Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.38Inherited
    49764,48452
  • 49764 - HSP20-like chaperones
  • 48452 - TPR-like
  • 0.004988Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 1Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.006408Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.006408Inherited
    50729,50044
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.005632Inherited
    57889,50729
  • 57889 - Cysteine-rich domain
  • 50729 - PH domain-like
  • 0.003307Inherited
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0.02348Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.06843Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.9094Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.1408Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.03068Inherited
    56112,64268
  • 56112 - Protein kinase-like (PK-like)
  • 64268 - PX domain
  • 0.1408Inherited
    64268,49562
  • 64268 - PX domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.1408Inherited
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0.006408Inherited
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05526Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.06613Inherited
    50044,48065
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.002778Inherited
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.007192Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.01412Inherited
    82754,82754
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.01217Inherited
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0.03404Inherited
    47473,47576
  • 47473 - EF-hand
  • 47576 - Calponin-homology domain, CH-domain
  • 0.02081Inherited
    55753,47050
  • 55753 - Actin depolymerizing proteins
  • 47050 - VHP, Villin headpiece domain
  • 0.002013Inherited
    50156,52540
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002778Inherited
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0.07097Inherited
    54236,50729
  • 54236 - Ubiquitin-like
  • 50729 - PH domain-like
  • 0.1253Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.3586Inherited
    89837,89837
  • 89837 - Doublecortin (DC)
  • 89837 - Doublecortin (DC)
  • 0.002791Inherited
    57997,52540
  • 57997 - Tropomyosin
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02081Inherited
    48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.001283Inherited
    50729,74788
  • 50729 - PH domain-like
  • 74788 - Cullin repeat-like
  • 0.02081Inherited
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0.001009Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    81995,54236,50729
  • 81995 - beta-sandwich domain of Sec23/24
  • 54236 - Ubiquitin-like
  • 50729 - PH domain-like
  • 0Direct
    46966,47473,47473
  • 46966 - Spectrin repeat
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0Direct
    75399,46966,46966
  • 75399 - Plakin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    103652,50729,57889
  • 103652 - G protein-binding domain
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    49265,49265,48726
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    51905,47576,57716
  • 51905 - FAD/NAD(P)-binding domain
  • 47576 - Calponin-homology domain, CH-domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    49265,48726,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    56112,48726,48726
  • 56112 - Protein kinase-like (PK-like)
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    48726,49265,56112
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49265,56112,48726
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 48726 - Immunoglobulin
  • 0Direct
    90257,90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0Direct
    46966,46966,47473
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 47473 - EF-hand
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    63748,48371,49785
  • 63748 - Tudor/PWWP/MBT
  • 48371 - ARM repeat
  • 49785 - Galactose-binding domain-like
  • 0Direct
    51338,51556,51338
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0.000000000000003737Direct
    50405,50405,50405
  • 50405 - Actin-crosslinking proteins
  • 50405 - Actin-crosslinking proteins
  • 50405 - Actin-crosslinking proteins
  • 0.000000000000005554Direct
    55753,82754,55753
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 0.000000000000009141Direct
    47576,46966,46966
  • 47576 - Calponin-homology domain, CH-domain
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.000000000000009141Direct
    55753,55753,82754
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.00000000000002495Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.00000000000004721Direct
    56112,82615,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0.00000000000004892Direct
    109880,109885,109885
  • 109880 - A middle domain of Talin 1
  • 109885 - I/LWEQ domain
  • 109885 - I/LWEQ domain
  • 0.0000000000002732Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.0000000000003033Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0000000000004588Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0000000000007749Direct
    55753,55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.0000000000007779Direct
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.00000000001381Direct
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0000000001979Direct
    47220,47220,109885
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 109885 - I/LWEQ domain
  • 0.00000003216Direct
    109885,109885,47220
  • 109885 - I/LWEQ domain
  • 109885 - I/LWEQ domain
  • 47220 - alpha-catenin/vinculin-like
  • 0.0000001211Direct
    109885,47220,47220
  • 109885 - I/LWEQ domain
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.0000001211Direct
    54001,143791,143791
  • 54001 - Cysteine proteinases
  • 143791 - DUSP-like
  • 143791 - DUSP-like
  • 0.0000001567Direct
    82754,55753,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.0000003731Direct
    109885,109885,109885
  • 109885 - I/LWEQ domain
  • 109885 - I/LWEQ domain
  • 109885 - I/LWEQ domain
  • 0.0000003881Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000005799Direct
    47576,57716,57716
  • 47576 - Calponin-homology domain, CH-domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.0000009604Direct
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.00000152Direct
    75399,75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0.000001528Direct
    48065,50729,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.000001625Direct
    57889,50729,69322
  • 57889 - Cysteine-rich domain
  • 50729 - PH domain-like
  • 69322 - Tricorn protease domain 2
  • 0.000003721Direct
    46966,46966,50044
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 50044 - SH3-domain
  • 0.000009828Direct
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.00001703Direct
    54001,49758,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.00002231Direct
    90257,57997,90257
  • 90257 - Myosin rod fragments
  • 57997 - Tropomyosin
  • 90257 - Myosin rod fragments
  • 0.00002231Direct
    54001,49758,49562
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.00002231Direct
    47220,47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.00002853Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0001138Direct
    48452,48371,48371
  • 48452 - TPR-like
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.0001694Direct
    49899,57196,56496
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.0001694Direct
    56496,49899,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0001694Direct
    57196,56496,49899
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0001694Direct
    49785,49899,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000243Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0004118Direct
    49265,48726,49265
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.0004171Direct
    103657,50729,48350
  • 103657 - BAR/IMD domain-like
  • 50729 - PH domain-like
  • 48350 - GTPase activation domain, GAP
  • 0.0004517Direct
    46966,50044,46966
  • 46966 - Spectrin repeat
  • 50044 - SH3-domain
  • 46966 - Spectrin repeat
  • 0.0005229Direct
    48726,48726,56112
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0.0005926Direct
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02027Inherited
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.01538Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.1408Inherited
    51045,47473,47473
  • 51045 - WW domain
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.002778Inherited
    46966,46966,51045
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 0.007591Inherited
    46966,51045,47473
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 47473 - EF-hand
  • 0.007591Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.09048Inherited
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 1Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.006408Inherited
    48065,50729,50044
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.002222Inherited
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0.01165Inherited
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.01533Inherited
    48371,56112,64268
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 64268 - PX domain
  • 0.1408Inherited
    56112,64268,49562
  • 56112 - Protein kinase-like (PK-like)
  • 64268 - PX domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.1408Inherited
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.006408Inherited
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.08798Inherited
    50044,48065,50729
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.007591Inherited
    49265,49265,56496
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.003943Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.0265Inherited
    55753,82754,82754
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.01217Inherited
    82754,82754,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 0.01217Inherited
    55753,55753,47050
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 47050 - VHP, Villin headpiece domain
  • 0.002013Inherited
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.002778Inherited
    49899,57196,57184
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.06459Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.4119Inherited
    48403,48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.06843Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
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