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Biological Process (BP): multicellular organism development

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Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + 3:   biological_process [GO:0008150] <24>
+ + 2:   developmental process [GO:0032502] <12>(88|106) (562|634|415)
+ + 2:   multicellular organismal process [GO:0032501] <6>(93|111) (573|658|432)
+ + 2:   single-organism process [GO:0044699] <23>(290|375) (996|1199|711)
+ 1:   anatomical structure development [GO:0048856] <208>(86|100) (540|615|406)
+ 1:   single-multicellular organism process [GO:0044707] <74>(83|99) (548|635|419)
+ 1:   single-organism developmental process [GO:0044767] <413>(85|101) (556|628|408)
0:   multicellular organism development [GO:0007275] <28>(76|90) (505|574|376)
- 1:   system development [GO:0048731] <30>(67|82) (479|532|350)
- 1:   tube development [GO:0035295] <26>(6|8) (184|143|80)
- 1:   post-embryonic development [GO:0009791] <19>(14|14) (165|106|58)
- 1:   pattern specification process [GO:0007389] <17>(2|2) (145|110|80)
- 1:   embryo development [GO:0009790] <10>(12|14) (230|213|129)
- 1:   instar larval or pupal development [GO:0002165] <7>(2|1) (99|67|39)
- 1:   larval development [GO:0002164] <7>(0|0) (50|34|22)
- 1:   abscission [GO:0009838] <6>(0|0) (3|0|0)
- 1:   male sex differentiation [GO:0046661] <6>(1|2) (41|18|8)
- 1:   cuticle development [GO:0042335] <5>(0|0) (36|24|13)
- 1:   germ-line sex determination [GO:0018992] <5>(0|0) (3|0|0)
- 1:   appendage development [GO:0048736] <4>(3|3) (102|76|61)
- 1:   cellularization [GO:0007349] <4>(1|0) (21|8|1)
- 1:   somatic sex determination [GO:0018993] <4>(0|0) (3|0|0)
- 1:   development of primary sexual characteristics [GO:0045137] <3>(4|5) (38|19|9)
- 1:   female sex differentiation [GO:0046660] <3>(4|4) (23|13|8)
- 1:   metamorphosis [GO:0007552] <3>(2|1) (85|59|36)
- 1:   multicellular organism aging [GO:0010259] <3>(1|1) (23|11|2)
- 1:   polyphenic determination [GO:0048647] <3>(0|0) (0|0|0)
- 1:   female sex determination [GO:0030237] <2>(0|0) (3|0|0)
- 1:   gametophyte development [GO:0048229] <2>(1|0) (17|6|2)
- 1:   hatching [GO:0035188] <2>(1|1) (3|0|0)
- 1:   male sex determination [GO:0030238] <2>(0|0) (2|3|3)
- 1:   primary sex determination [GO:0007538] <2>(0|0) (3|0|0)
- 1:   processes downstream of sex determination signal [GO:0007545] <2>(0|0) (0|0|0)
- 1:   eclosion [GO:0007562] <1>(0|0) (1|0|0)
- 1:   embryo implantation [GO:0007566] <1>(1|1) (10|5|2)
- 1:   cell competition in a multicellular organism [GO:0035212](0|0) (4|1|0)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
beta-beta-alpha zinc fingers0.00086630Direct
Core binding factor beta, CBF0.00000000011740.000000003305Direct
Fibronectin type III0.00045070.0000000000001802Direct
HLH, helix-loop-helix DNA-binding domain0.00017740.000000006737Direct
Mitochondrial cytochrome c oxidase subunit VIIb0.00000026290.00002939Direct
Preprotein translocase SecY subunit0.0000000026680.0001413Direct
Sema domain0.00000026290Direct
Spectrin repeat0.000000019370.000027Direct
SRF-like0.000052820.000001598Direct
Stathmin00Direct
S-adenosyl-L-methionine-dependent methyltransferases11Inherited
NAD(P)-binding Rossmann-fold domains11Inherited
Immunoglobulin0.089160Inherited
Cu,Zn superoxide dismutase-like0.18620.4628Inherited
Troponin coil-coiled subunits0.96931Inherited
p53-like transcription factors0.20720.000001456Inherited
Acid proteases11Inherited
alpha/beta-Hydrolases11Inherited
(Phosphotyrosine protein) phosphatases II0.058840.0009714Inherited
Tropomyosin0.0014451Inherited
Serpins0.65251Inherited
WD40 repeat-like0.046020.542Inherited
Spermadhesin, CUB domain0.0000035030.3474Inherited
EF-hand10.6379Inherited
Integrin alpha N-terminal domain0.00018130.008186Inherited
POZ domain0.0012640.2692Inherited
Calcium-dependent phosphotriesterase0.53181Inherited
ALDH-like0.34631Inherited
Inhibitor of apoptosis (IAP) repeat0.1161Inherited
RNase A-like0.000000000021330.009211Inherited
Interleukin 8-like chemokines0.11330.08411Inherited
Concanavalin A-like lectins/glucanases0.0049370.000000002472Inherited
PEBP-like0.036120.6805Inherited
Annexin0.96811Inherited
14-3-3 protein0.024440.5516Inherited
Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin0.000019230.1863Inherited
Tubulin C-terminal domain-like0.00019410.0506Inherited
Heme-dependent peroxidases0.61951Inherited
Radical SAM enzymes0.99181Inherited
Caspase-like0.08950.4277Inherited
Actin depolymerizing proteins0.2620.5598Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.00004610.6723Inherited
Metalloproteases ("zincins"), catalytic domain0.48540.03487Inherited
Cytokine0.022720.03754Inherited
Ubiquitin-like0.85550.2254Inherited
Homeodomain-like0.011380Inherited
Cysteine proteinases0.15091Inherited
Ankyrin repeat0.035290.6301Inherited
Globin-like11Inherited
Mitochondrial carrier0.70271Inherited
PX domain0.0000074460.9041Inherited
NAP-like0.40410.9755Inherited
SET domain0.048460.8066Inherited
RNA-binding domain, RBD0.61950.7593Inherited
Metallothionein0.00072970.3493Inherited
Trypsin-like serine proteases11Inherited
Aquaporin-like0.0023490.9419Inherited
Lipocalins11Inherited
Protein kinase-like (PK-like)0.0068870.0000002834Inherited
Profilin (actin-binding protein)0.69330.9748Inherited
AF0104/ALDC/Ptd012-like0.017840.05005Inherited
Nucleotide-diphospho-sugar transferases0.60791Inherited
Cystine-knot cytokines0.0030720Inherited
eIF4e-like0.46851Inherited
Calponin-homology domain, CH-domain0.96230.2731Inherited
Tubulin chaperone cofactor A0.00028940.03362Inherited
ARM repeat0.15090.9375Inherited
Family A G protein-coupled receptor-like11Inherited
P-loop containing nucleoside triphosphate hydrolases11Inherited
Phospholipase D/nuclease0.1160.5136Inherited
NagB/RpiA/CoA transferase-like0.171Inherited
Bcl-2 inhibitors of programmed cell death0.00043370.6341Inherited
4-helical cytokines0.35480.05228Inherited
Acyl-CoA N-acyltransferases (Nat)11Inherited
KRAB domain (Kruppel-associated box)0.78621Inherited
(Trans)glycosidases0.049291Inherited


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Family

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Bee venom hyaluronidase0.0000000000000011680Direct
BTB/POZ domain0.00071230.0000109Direct
Core binding factor beta, CBF0.00000000033280.00000001129Direct
Fibronectin type III0.00066690.00000000000207Direct
Forkhead DNA-binding domain0.00000043110.00004916Direct
Higher-molecular-weight phosphotyrosine protein phosphatases0.00000000011480.000000245Direct
HLH, helix-loop-helix DNA-binding domain0.00012350.00000003162Direct
Homeodomain0.0000000048950Direct
Laminin G-like module0.000061690.0000000264Direct
Mitochondrial cytochrome c oxidase subunit VIIb0.00000043110.00004583Direct
Paired domain00.000001241Direct
Platelet-derived growth factor-like0.00026080Direct
Preprotein translocase SecY subunit0.000000010940.0004002Direct
Sema domain0.00000043110Direct
Spectrin repeat0.000000035720.00006432Direct
SRF-like0.000025920.000002471Direct
Stathmin00Direct
T-box0.000061690.0003486Direct
C5 cytosine-specific DNA methylase, DCM0.0014170.005045Inherited
Tyrosine-dependent oxidoreductases11Inherited
Cu,Zn superoxide dismutase-like0.15720.4568Inherited
Protein prenyltransferases0.00046160.2163Inherited
Troponin I0.91671Inherited
UDPGT-like0.54791Inherited
Pepsin-like11Inherited
Extended AAA-ATPase domain0.85381Inherited
G proteins11Inherited
Tropomyosin0.0015181Inherited
Spermadhesin, CUB domain0.0000051690.3389Inherited
Integrin alpha N-terminal domain0.00000043110.006416Inherited
Ngr ectodomain-like0.36130.00000006312Inherited
Ephrin ectodomain0.000098130.001463Inherited
ALDH-like0.59071Inherited
Inhibitor of apoptosis (IAP) repeat0.099351Inherited
Ribonuclease A-like0.00000000018760.009353Inherited
Galectin (animal S-lectin)0.00010840.02596Inherited
Interleukin 8-like chemokines0.090390.09098Inherited
Phosphatidylethanolamine binding protein0.029580.2343Inherited
Annexin0.90951Inherited
14-3-3 protein0.019320.5407Inherited
Plant lipid-transfer and hydrophobic proteins0.00000072250.02059Inherited
Tubulin, C-terminal domain0.00026080.0538Inherited
CCP-like0.56230.9011Inherited
Plastocyanin/azurin-like0.015590.8777Inherited
Germin/Seed storage 7S protein0.077470.6292Inherited
MoCo biosynthesis proteins0.0082280.7965Inherited
Cofilin-like0.2250.3132Inherited
Formate/glycerate dehydrogenases, substrate-binding domain0.000061690.8184Inherited
Astacin0.073430.1223Inherited
Fibroblast growth factors (FGF)0.0065840.0002235Inherited
Calmodulin-like0.79080.9401Inherited
Isoprenyl diphosphate synthases0.37861Inherited
Papain-like0.11380.9277Inherited
Ankyrin repeat0.12690.757Inherited
Globins0.93891Inherited
Mitochondrial carrier0.70371Inherited
PX domain0.000013520.853Inherited
NAP-like0.36130.9382Inherited
Canonical RBD0.56230.3393Inherited
Metallothionein0.0021040.5036Inherited
Eukaryotic proteases11Inherited
Aquaporin-like0.0017111Inherited
Penta-EF-hand proteins0.18151Inherited
Rhodopsin-like0.95971Inherited
Retinol binding protein-like0.64880.9834Inherited
Carboxylesterase0.79731Inherited
Classic zinc finger, C2H20.017150Inherited
Phoshatidylinositol transfer protein, PITP0.0000018320.01876Inherited
AF0104-like0.000078640.007028Inherited
Profilin (actin-binding protein)0.63560.9355Inherited
Ferritin0.0012640.5509Inherited
Gonadodropin/Follitropin0.021870.7591Inherited
Translation initiation factor eIF4e0.56271Inherited
Calponin-homology domain, CH-domain0.90780.3421Inherited
Protein kinases, catalytic subunit0.001140.000004353Inherited
SelR domain0.025070.6875Inherited
Tubulin chaperone cofactor A0.00046950.04739Inherited
CAF1-like ribonuclease0.18150.1981Inherited
Arylsulfatase0.11810.001189Inherited
Thioesterases0.000034950.01421Inherited
Nuclease0.099350.2422Inherited
IF2B-like0.14550.1751Inherited
WD40-repeat0.073111Inherited
Long-chain cytokines0.0041320.00002631Inherited
Bcl-2 inhibitors of programmed cell death0.00030980.6266Inherited
Short-chain cytokines0.092210.2037Inherited
C1 set domains (antibody constant domain-like)0.65221Inherited
Caspase catalytic domain0.073530.4635Inherited
Clathrin coat assembly domain0.000010650.1636Inherited
KRAB domain (Kruppel-associated box)0.83021Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Homeodomain-like0Direct
Hedgehog/DD-peptidase0Direct
beta-beta-alpha zinc fingers0Direct
Immunoglobulin0Direct
Stathmin0Direct
Transcription factor STAT-4 N-domain0Direct
Snake toxin-like0Direct
SMAD MH1 domain0Direct
Sema domain0Direct
Cystine-knot cytokines0Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
A heparin-binding domain0Direct
Heparin-binding domain from vascular endothelial growth factor0Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
Domain from hypothetical 2610208m17rik protein0Direct
DPY module0Direct
Midkine0.000000000000001898Direct
Fibronectin type III0.00000000000009639Direct
Growth factor receptor domain0.000000000006771Direct
Triple coiled coil domain of C-type lectins0.00000000003202Direct
EGF/Laminin0.0000000002087Direct
Cadherin-like0.000000001143Direct
Concanavalin A-like lectins/glucanases0.000000001467Direct
Core binding factor beta, CBF0.000000001968Direct
Methuselah ectodomain0.000000001968Direct
DNA-binding pseudobarrel domain0.000000003594Direct
HLH, helix-loop-helix DNA-binding domain0.000000004055Direct
Plexin repeat0.0000000274Direct
TAF(II)230 TBP-binding fragment0.00000003755Direct
DNA-binding protein LAG-1 (CSL)0.0000001534Direct
Protein kinase-like (PK-like)0.0000001782Direct
Helical domain of Sec23/240.0000002973Direct
SMAD/FHA domain0.0000005379Direct
p53-like transcription factors0.0000009355Direct
SRF-like0.000001028Direct
TAFH domain-like0.000001493Direct
GDNF receptor-like0.000001709Direct
Granulin repeat0.000002496Direct
STAT0.000004304Direct
Zn-finger domain of Sec23/240.000008501Direct
CCHHC domain0.00001202Direct
"Winged helix" DNA-binding domain0.00001365Direct
Spectrin repeat0.0000181Direct
Mitochondrial cytochrome c oxidase subunit VIIb0.00001972Direct
Bromodomain0.00003589Direct
TSP-1 type 1 repeat0.00004202Direct
Dimerization cofactor of HNF-1 alpha0.000046Direct
F1 ATPase inhibitor, IF1, C-terminal domain0.00004988Direct
FAT domain of focal adhesion kinase0.00005146Direct
GTPase activation domain, GAP0.00006365Direct
DNA-binding domain0.00008985Direct
Preprotein translocase SecY subunit0.00009713Direct
Frizzled cysteine-rich domain0.0001154Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0001438Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0.0001983Direct
Ran binding protein zinc finger-like0.0002446Direct
Putative DNA-binding domain0.0002636Direct
FYVE/PHD zinc finger0.000267Direct
Hedgehog/intein (Hint) domain0.0002703Direct
C-terminal autoproteolytic domain of nucleoporin nup980.0003454Direct
HMG-box0.0003599Direct
BRCA2 helical domain0.0004284Direct
BRCA2 tower domain0.0004284Direct
GFP-like0.000459Direct
SAND domain-like0.0005664Direct
(Phosphotyrosine protein) phosphatases II0.0006911Direct
lambda repressor-like DNA-binding domains0.0007622Direct
Plakin repeat0.0007973Direct
Suppressor of Fused, N-terminal domain0.000858Direct
SAM/Pointed domain0.0009988Direct
UBC-like1Inherited
MFS general substrate transporter1Inherited
WRKY DNA-binding domain0.6274Inherited
Prefoldin0.4014Inherited
YWTD domain0.9582Inherited
Nudix1Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain1Inherited
Arabinanase/levansucrase/invertase1Inherited
Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin0.1508Inherited
Profilin (actin-binding protein)0.8774Inherited
RGC domain-like0.07188Inherited
ALDH-like1Inherited
WW domain0.3156Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Cullin homology domain0.1644Inherited
Elafin-like0.1593Inherited
SAP domain0.1027Inherited
Synuclein0.9385Inherited
PKD domain1Inherited
Carbonic anhydrase0.8426Inherited
Single hybrid motif1Inherited
Rudiment single hybrid motif1Inherited
PABC (PABP) domain0.2418Inherited
YhbY-like0.5878Inherited
AF0104/ALDC/Ptd012-like0.0388Inherited
Calponin-homology domain, CH-domain0.225Inherited
NTF2-like1Inherited
Calcium ATPase, transmembrane domain M0.4987Inherited
Calcium ATPase, transduction domain A0.5463Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.5035Inherited
WD40 repeat-like0.4632Inherited
Kelch motif0.03811Inherited
Geminin coiled-coil domain1Inherited
Glycerol-3-phosphate (1)-acyltransferase1Inherited
Dihydrofolate reductase-like0.9395Inherited
Spermadhesin, CUB domain0.2896Inherited
Tumor suppressor gene product Apc0.005557Inherited
N-terminal coiled coil domain from apc0.005557Inherited
Ricin B-like lectins1Inherited
Thioredoxin-like1Inherited
Serpins0.9726Inherited
E set domains0.7117Inherited
TNF-like0.5432Inherited
Eukaryotic type KH-domain (KH-domain type I)0.6812Inherited
Polo-box domain1Inherited
Cysteine proteinases1Inherited
V-type ATP synthase subunit C0.3925Inherited
YVTN repeat-like/Quinoprotein amine dehydrogenase0.009641Inherited
Actin-like ATPase domain1Inherited
LDL receptor-like module1Inherited
ARM repeat0.8392Inherited
Nucleotide-diphospho-sugar transferases1Inherited
Glycoside hydrolase/deacetylase1Inherited
Formin homology 2 domain (FH2 domain)0.3157Inherited
Invertebrate chitin-binding proteins1Inherited
alpha/beta-Hydrolases1Inherited
Periplasmic binding protein-like I1Inherited
Nucleotide cyclase1Inherited
PUA domain-like1Inherited
Creatinase/aminopeptidase1Inherited
Pseudouridine synthase1Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain1Inherited
Histone-fold1Inherited
Ribosomal proteins S24e, L23 and L15e0.496Inherited
NHL repeat0.326Inherited
B-box zinc-binding domain0.3052Inherited
NAP-like0.8782Inherited
Complement control module/SCR domain0.264Inherited
4-helical cytokines0.04059Inherited
HD-domain/PDEase-like1Inherited
GAF domain-like1Inherited
GroEL equatorial domain-like1Inherited
GroEL apical domain-like1Inherited
Cysteine-rich DNA binding domain, (DM domain)0.002902Inherited
Chromo domain-like0.06582Inherited
Leukotriene A4 hydrolase N-terminal domain1Inherited
Galactose-binding domain-like0.5944Inherited
ADC-like0.6176Inherited
Cdc48 domain 2-like0.06907Inherited
Hect, E3 ligase catalytic domain0.5112Inherited
SOCS box-like0.8383Inherited
DEATH domain0.2649Inherited
Mss4-like1Inherited
ARID-like0.05177Inherited
VHP, Villin headpiece domain0.1584Inherited
DNA/RNA polymerases1Inherited
CRAL/TRIO domain1Inherited
cAMP-binding domain-like0.9812Inherited
FAD/NAD(P)-binding domain1Inherited
FAD-linked reductases, C-terminal domain1Inherited
Leucine zipper domain0.6085Inherited
GCM domain0.07188Inherited
Mannose 6-phosphate receptor domain1Inherited
PK C-terminal domain-like0.1871Inherited
PK beta-barrel domain-like0.9489Inherited
Thiolase-like1Inherited
NagB/RpiA/CoA transferase-like1Inherited
Transducin (alpha subunit), insertion domain1Inherited
SH2 domain0.119Inherited
Trimeric LpxA-like enzymes1Inherited
Metallothionein0.2913Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase1Inherited
C-terminal domain of PLC-beta1Inherited
Smc hinge domain0.4663Inherited
SET domain0.71Inherited
HIT/MYND zinc finger-like0.02958Inherited
Sec1/munc18-like (SM) proteins0.9736Inherited
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain0.2574Inherited
VPS9 domain0.8281Inherited
PRC-barrel domain0.3885Inherited
TIMP-like0.01224Inherited
Cap-Gly domain0.8619Inherited
ArfGap/RecO-like zinc finger0.851Inherited
DHH phosphoesterases0.6934Inherited
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)0.1359Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor1Inherited
Calcium-dependent phosphotriesterase1Inherited
Hypothetical protein AF0491, middle domain0.001994Inherited
FYSH domain0.04786Inherited
Inhibitor of apoptosis (IAP) repeat0.9907Inherited
SBT domain0.001994Inherited
Nucleotidylyl transferase1Inherited
RNI-like1Inherited
L domain-like0.001919Inherited
Bet v1-like0.7501Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases1Inherited
ValRS/IleRS/LeuRS editing domain1Inherited
KRAB domain (Kruppel-associated box)1Inherited
C-type lectin-like0.8334Inherited
Acetyl-CoA synthetase-like1Inherited
Radical SAM enzymes1Inherited
Toll/Interleukin receptor TIR domain1Inherited
PP2C-like1Inherited
RUN domain-like0.6523Inherited
Actin depolymerizing proteins0.4793Inherited
Transglutaminase, two C-terminal domains1Inherited
Neurotransmitter-gated ion-channel transmembrane pore1Inherited
Nicotinic receptor ligand binding domain-like1Inherited
Phospholipase A2, PLA21Inherited
Tautomerase/MIF0.7431Inherited
Voltage-gated potassium channels1Inherited
Cu,Zn superoxide dismutase-like0.3919Inherited
AbfB domain0.4843Inherited
Serine protease inhibitors1Inherited
HAD-like1Inherited
Nuclear receptor ligand-binding domain0.4589Inherited
Thyroglobulin type-1 domain0.24Inherited
Trypsin-like serine proteases1Inherited
MHC antigen-recognition domain1Inherited
Regulator of G-protein signaling, RGS0.01076Inherited
Thymidylate synthase/dCMP hydroxymethylase0.2953Inherited
post-AAA+ oligomerization domain-like1Inherited
PurM C-terminal domain-like0.8675Inherited
PurM N-terminal domain-like0.8675Inherited
DNase I-like0.9768Inherited
Formyltransferase0.8754Inherited
Soluble quinoprotein glucose dehydrogenase0.02559Inherited
Tetraspanin1Inherited
Putative isomerase YbhE0.8227Inherited
Retrovirus capsid dimerization domain-like1Inherited
L27 domain0.2891Inherited
A DNA-binding domain in eukaryotic transcription factors0.2172Inherited
Multidrug resistance efflux transporter EmrE1Inherited
Band 7/SPFH domain1Inherited
SH3-domain0.1478Inherited
LEM domain0.11Inherited
Ankyrin repeat0.5438Inherited
Notch domain0.01165Inherited
HCP-like1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
AXH domain0.1292Inherited
Cysteine-rich domain1Inherited
G protein-binding domain0.03058Inherited
Sec7 domain0.03349Inherited
Moesin tail domain0.8281Inherited
Clavaminate synthase-like1Inherited
TPR-like1Inherited
S-adenosylmethionine synthetase0.2574Inherited
DNA-glycosylase1Inherited
Tropomyosin1Inherited
TB module/8-cys domain0.0247Inherited
Myosin S1 fragment, N-terminal domain0.7459Inherited
Integrin beta tail domain0.8448Inherited
Metalloproteases ("zincins"), catalytic domain0.02675Inherited
Blood coagulation inhibitor (disintegrin)0.3348Inherited
SWIB/MDM2 domain0.04996Inherited
DNA ligase/mRNA capping enzyme, catalytic domain1Inherited
Galactose oxidase, central domain0.5498Inherited
ATP-dependent DNA ligase DNA-binding domain0.4923Inherited
Annexin1Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.4177Inherited
F-box domain1Inherited
Lipoxigenase0.008458Inherited
Heme-dependent peroxidases0.9109Inherited
Intermediate filament protein, coiled coil region0.1265Inherited
LigT-like0.06803Inherited
Lipocalins1Inherited
Apolipoprotein A-I0.9515Inherited
Type II DNA topoisomerase0.4344Inherited
Translation proteins1Inherited
TNF receptor-like0.07215Inherited
Kazal-type serine protease inhibitors0.02677Inherited
F1F0 ATP synthase subunit C0.5803Inherited
FF domain0.3361Inherited
Nuclear receptor coactivator interlocking domain0.3155Inherited
PRTase-like1Inherited
HMA, heavy metal-associated domain1Inherited
ABC transporter transmembrane region1Inherited
DBL homology domain (DH-domain)0.02004Inherited
PR-1-like1Inherited
Chelatase0.6669Inherited
Globin-like1Inherited
Mitochondrial carrier1Inherited
Phoshotransferase/anion transport protein0.8548Inherited
Ribosomal protein S3 C-terminal domain0.5878Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain1Inherited
Carboxypeptidase regulatory domain-like0.1027Inherited
RCC1/BLIP-II0.002108Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain0.02256Inherited
Aspartate/ornithine carbamoyltransferase0.09206Inherited
LEA14-like0.291Inherited
BPTI-like1Inherited
Doublecortin (DC)0.013Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.583Inherited
DUSP-like0.05466Inherited
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain0.07188Inherited
Zinc beta-ribbon0.9866Inherited
Transferrin receptor-like dimerisation domain0.9478Inherited
Barwin-like endoglucanases1Inherited
PHL pollen allergen1Inherited
Tubulin C-terminal domain-like0.03924Inherited
Tubulin nucleotide-binding domain-like0.05931Inherited
Six-hairpin glycosidases1Inherited
CAD & PB1 domains0.5927Inherited
CheY-like1Inherited
NAC domain0.9496Inherited
Ferritin-like0.9803Inherited
PH domain-like0.01043Inherited
BAR/IMD domain-like1Inherited
Calpain large subunit, middle domain (domain III)1Inherited
Prion-like0.1335Inherited
Hairpin loop containing domain-like1Inherited
Ribonuclease PH domain 2-like1Inherited
Zn-dependent exopeptidases1Inherited
Ribosomal protein S5 domain 2-like1Inherited
Cupredoxins1Inherited
Cytochrome P4501Inherited
PreATP-grasp domain1Inherited
Class I glutamine amidotransferase-like1Inherited
Methylglyoxal synthase-like0.2457Inherited
Carbamoyl phosphate synthetase, large subunit connection domain0.04715Inherited
Cyclin-like0.4923Inherited
UBA-like1Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain1Inherited
Riboflavin synthase domain-like1Inherited
ACT-like1Inherited
Nitric oxide (NO) synthase oxygenase domain1Inherited
Sialidases0.8251Inherited
Flavoproteins1Inherited
Cytochrome c oxidase subunit E0.0516Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.6695Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase1Inherited
PsbU/PolX domain-like0.8266Inherited
DNA polymerase beta, N-terminal domain-like0.8966Inherited
Cytidine deaminase-like1Inherited
Sec63 N-terminal domain-like0.3141Inherited
Nucleotidyltransferase1Inherited
DNA repair protein MutS, domain I0.4888Inherited
DNA repair protein MutS, domain II0.4567Inherited
FAS1 domain0.01166Inherited
Dystroglycan, domain 20.001787Inherited
RNase III domain-like0.4402Inherited
Acyl-CoA N-acyltransferases (Nat)1Inherited
Retrovirus zinc finger-like domains1Inherited
Metallo-dependent hydrolases1Inherited
Composite domain of metallo-dependent hydrolases0.2718Inherited
RING/U-box0.6537Inherited
UDP-Glycosyltransferase/glycogen phosphorylase1Inherited
RmlC-like cupins1Inherited
Phosphoenolpyruvate/pyruvate domain1Inherited
eIF4e-like1Inherited
Rap/Ran-GAP0.8699Inherited
Hook domain0.005512Inherited
DNA repair protein MutS, domain III0.6483Inherited
Seven-hairpin glycosidases0.9846Inherited
Fumarate reductase respiratory complex transmembrane subunits1Inherited
CBS-domain pair1Inherited
Aminoacid dehydrogenase-like, N-terminal domain1Inherited
HRDC-like0.6317Inherited
Proton glutamate symport protein1Inherited
PEBP-like0.5906Inherited
Homodimeric domain of signal transducing histidine kinase1Inherited
Quinoprotein alcohol dehydrogenase-like0.3325Inherited
Clathrin adaptor appendage domain0.5964Inherited
Subdomain of clathrin and coatomer appendage domain0.7917Inherited
KA1-like0.9978Inherited
PAZ domain1Inherited
Ribonuclease H-like1Inherited
MIT domain0.7231Inherited
Pectin lyase-like1Inherited
AhpD-like0.9996Inherited
14-3-3 protein0.4719Inherited
PDZ domain-like0.002238Inherited
Cullin repeat-like0.583Inherited
Ubiquitin-like0.1841Inherited
beta-sandwich domain of Sec23/240.03894Inherited
Plus3-like0.2574Inherited
BAH domain0.4843Inherited
C-terminal, gelsolin-like domain of Sec23/240.0402Inherited
EB1 dimerisation domain-like0.2853Inherited
Insulin-like0.7092Inherited
TATA-box binding protein-like0.005512Inherited
A middle domain of Talin 10.1359Inherited
I/LWEQ domain0.3155Inherited
Phospholipase D/nuclease0.4375Inherited
BRK domain-like0.2692Inherited
The spindle assembly checkpoint protein mad20.8281Inherited
Activator of Hsp90 ATPase, Aha10.03832Inherited
Alkaline phosphatase-like0.3416Inherited
alpha-catenin/vinculin-like0.9978Inherited
FKBP-like1Inherited
BRCT domain0.6905Inherited
GAS2 domain-like0.02038Inherited
EF-hand0.5509Inherited
RNA-binding domain, RBD0.6647Inherited
PYP-like sensor domain (PAS domain)1Inherited
Substrate-binding domain of HMG-CoA reductase0.5784Inherited
NAD-binding domain of HMG-CoA reductase0.5784Inherited
Lamin A/C globular tail domain0.2607Inherited
Nop domain0.4044Inherited
Eferin C-derminal domain-like0.01049Inherited
C-terminal domain of adenylylcyclase associated protein0.7593Inherited
N-terminal domain of adenylylcyclase associated protein, CAP0.7593Inherited
Protein serine/threonine phosphatase 2C, C-terminal domain0.26Inherited
Chitinase insertion domain0.9989Inherited
PAH2 domain0.1027Inherited
HR1 repeat1Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4881Inherited
PWI domain0.01491Inherited
Poly A polymerase C-terminal region-like0.3917Inherited
SEA domain0.9692Inherited
Tubulin chaperone cofactor A0.02579Inherited
C-terminal domain of Ku800.3179Inherited
BEACH domain0.8281Inherited
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain0.4382Inherited
Delta-sleep-inducing peptide immunoreactive peptide0.3709Inherited
PX domain0.8059Inherited
SAICAR synthase-like0.3775Inherited
Multidrug efflux transporter AcrB transmembrane domain1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
Chaperone J-domain1Inherited
Succinyl-CoA synthetase domains1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
ACP-like1Inherited
GroES-like1Inherited
TRAF domain-like1Inherited
DHS-like NAD/FAD-binding domain0.9921Inherited
LuxS/MPP-like metallohydrolase1Inherited
HAND domain of the nucleosome remodeling ATPase ISWI0.08887Inherited
Orange domain-like0.003148Inherited
SPOC domain-like0.06068Inherited
Troponin coil-coiled subunits1Inherited
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain0.08688Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like1Inherited
MIR domain0.6811Inherited
Nucleic acid-binding proteins1Inherited
CCCH zinc finger1Inherited
Bcl-2 inhibitors of programmed cell death0.5475Inherited
Nucleoplasmin-like core domain0.967Inherited
Activating enzymes of the ubiquitin-like proteins0.6456Inherited
Tudor/PWWP/MBT0.001384Inherited
Caspase-like0.3606Inherited
HSP20-like chaperones1Inherited
Aquaporin-like0.8437Inherited
Second domain of FERM0.1428Inherited
gamma-Crystallin-like0.4Inherited
Cytokine0.02887Inherited
Glutamine synthetase, N-terminal domain0.1323Inherited
Glutamine synthetase/guanido kinase1Inherited
Kringle-like0.5222Inherited
Integrin domains0.05964Inherited
FnI-like domain0.1387Inherited
Integrin alpha N-terminal domain0.006047Inherited
HSP40/DnaJ peptide-binding domain1Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
Transducin (heterotrimeric G protein), gamma chain0.4568Inherited
GLA-domain1Inherited
Protease propeptides/inhibitors0.6156Inherited
Somatomedin B domain0.4753Inherited
Alpha-macroglobulin receptor domain0.6162Inherited
Mannose-binding lectins0.7261Inherited
Anthrax protective antigen0.4243Inherited
POZ domain0.2216Inherited
TAZ domain0.0247Inherited
Kix domain of CBP (creb binding protein)0.2781Inherited
SNF-like1Inherited
SNARE-like0.948Inherited
N-terminal domain of cbl (N-cbl)0.3925Inherited
Acid proteases1Inherited
Aconitase iron-sulfur domain0.9898Inherited
LeuD/IlvD-like1Inherited
Ras GEF0.2191Inherited
Connexin431Inherited
Mib/herc2 domain-like0.9385Inherited
Myosin rod fragments1Inherited
Class II aaRS and biotin synthetases1Inherited
Class II aaRS ABD-related1Inherited
PLC-like phosphodiesterases0.749Inherited
SRCR-like1Inherited
Family A G protein-coupled receptor-like1Inherited
ThrRS/AlaRS common domain0.5146Inherited
TGS-like0.9608Inherited
RNase A-like0.006821Inherited
Colipase-like0.3925Inherited
VHL0.3179Inherited
beta-N-acetylhexosaminidase-like domain0.422Inherited
Interleukin 8-like chemokines0.0663Inherited
Hormone receptor domain0.667Inherited
Fibrinogen C-terminal domain-like0.9877Inherited
vWA-like0.6552Inherited
dsRNA-binding domain-like1Inherited
Chicken cartilage matrix protein0.006362Inherited
CalX-like0.7935Inherited
Arginase/deacetylase0.6437Inherited
Periplasmic binding protein-like II1Inherited
Insert subdomain of RNA polymerase alpha subunit0.7686Inherited
RBP11-like subunits of RNA polymerase0.9434Inherited
p53 tetramerization domain0.9337Inherited
(Trans)glycosidases1Inherited
TSP type-3 repeat0.9515Inherited
Subtilisin-like0.4523Inherited
Hemopexin-like domain0.02887Inherited
PGBD-like0.2842Inherited
IP3 receptor type 1 binding core, domain 21Inherited
Assembly domain of cartilage oligomeric matrix protein1Inherited

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