SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Biological Process (BP): reproductive process

(show info)

Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ 1:   biological_process [GO:0008150] <24>
+ 1:   reproduction [GO:0000003] <6>(37|41) (304|189|85)
0:   reproductive process [GO:0022414] <78>(33|37) (289|181|83)
- 1:   single organism reproductive process [GO:0044702] <186>(27|29) (259|162|73)
- 1:   developmental process involved in reproduction [GO:0003006] <171>(20|22) (213|118|56)
- 1:   meiotic cell cycle process [GO:1903046] <75>(2|3) (54|22|4)
- 1:   multicellular organismal reproductive process [GO:0048609] <23>(11|13) (193|127|53)
- 1:   multi-organism reproductive process [GO:0044703] <15>(14|15) (214|138|64)
- 1:   gene conversion at mating-type locus [GO:0007534] <7>(0|0) (0|0|0)
- 1:   acrosome reaction [GO:0007340] <6>(0|0) (6|3|1)
- 1:   pollen-pistil interaction [GO:0009875] <5>(0|0) (1|0|0)
- 1:   response to pheromone involved in conjugation with cellular fusion [GO:0000749] <5>(0|0) (9|3|1)
- 1:   reproductive process in single-celled organism [GO:0022413] <4>(0|0) (6|1|0)
- 1:   fusome organization [GO:0045478] <3>(0|0) (1|0|0)
- 1:   male pronucleus assembly [GO:0035039] <3>(0|0) (4|0|0)
- 1:   regulation of transcription involved in meiotic cell cycle [GO:0051037] <3>(0|0) (1|0|0)
- 1:   P granule organization [GO:0030719] <2>(1|1) (2|0|0)
- 1:   budding cell bud growth [GO:0007117] <2>(0|0) (1|0|0)
- 1:   detection of stimulus involved in meiotic cell cycle checkpoint [GO:0072409] <2>(0|0) (0|0|0)
- 1:   oocyte nucleus localization involved in oocyte dorsal/ventral axis specification [GO:0051663] <2>(0|0) (1|0|0)
- 1:   photoperiodism, flowering [GO:0048573] <2>(0|0) (2|0|0)
- 1:   pole plasm RNA localization [GO:0007316] <2>(0|0) (5|2|0)
- 1:   signal transduction involved in conjugation with cellular fusion [GO:0032005] <2>(0|0) (3|1|0)
- 1:   spermatid nucleus differentiation [GO:0007289] <2>(0|0) (9|5|2)
- 1:   adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusio [GO:0000754] <1>(0|0) (0|0|0)
- 1:   cell wall organization involved in conjugation with cellular fusion [GO:0070871] <1>(0|0) (1|0|0)
- 1:   chromosome localization to nuclear envelope involved in homologous chromosome segregation [GO:0090220] <1>(0|0) (2|0|0)
- 1:   cytoplasmic transport, nurse cell to oocyte [GO:0007303] <1>(0|0) (2|1|1)
- 1:   detection of stimulus involved in meiotic spindle checkpoint [GO:1902397] <1>(0|0) (0|0|0)
- 1:   mucilage metabolic process involved in seed coat development [GO:0048359] <1>(1|1) (2|0|0)
- 1:   prevention of polyspermy [GO:0060468] <1>(1|1) (1|0|0)
- 1:   protein localization to meiotic spindle pole body [GO:1902441] <1>(0|0) (0|0|0)
- 1:   sperm chromatin condensation [GO:0035092] <1>(0|0) (8|4|2)
- 1:   sperm chromatin decondensation [GO:0035041] <1>(0|0) (3|0|0)
- 1:   DNA methylation involved in gamete generation [GO:0043046](1|1) (11|7|1)
- 1:   DNA recombinase assembly involved in gene conversion at mating-type locus [GO:0034624](0|0) (0|0|0)
- 1:   FtsZ-dependent cytokinesis [GO:0043093](0|0) (0|0|0)
- 1:   Wnt signaling pathway involved in animal/vegetal axis specification [GO:0060833](0|0) (0|0|0)
- 1:   acrosome matrix dispersal [GO:0002077](0|0) (0|0|0)
- 1:   activation of meiosis involved in egg activation [GO:0060466](0|0) (5|3|2)
- 1:   bicoid mRNA localization [GO:0045450](0|0) (3|1|0)
- 1:   border follicle cell delamination [GO:0030709](0|0) (3|1|0)
- 1:   cell adhesion involved in prostatic bud elongation [GO:0060519](0|0) (0|0|0)
- 1:   cell wall macromolecule catabolic process involved in cytogamy [GO:0032219](0|0) (0|0|0)
- 1:   clathrin-dependent endocytosis involved in vitellogenesis [GO:0061883](0|0) (1|0|0)
- 1:   female pronucleus assembly [GO:0035038](0|0) (1|0|0)
- 1:   fertilization, exchange of chromosomal proteins [GO:0035042](0|0) (0|0|0)
- 1:   gene conversion at mating-type locus, DNA double-strand break formation [GO:0000728](0|0) (0|0|0)
- 1:   gene conversion at mating-type locus, DNA double-strand break processing [GO:0031292](0|0) (0|0|0)
- 1:   gene conversion at mating-type locus, DNA repair synthesis [GO:0000734](0|0) (0|0|0)
- 1:   gene conversion at mating-type locus, termination of copy-synthesis [GO:0061500](0|0) (0|0|0)
- 1:   generative cell mitosis [GO:0055047](0|0) (1|0|0)
- 1:   heteroduplex formation involved in gene conversion at mating-type locus [GO:0010708](0|0) (0|0|0)
- 1:   karyogamy involved in conjugation with cellular fusion [GO:0000742](0|0) (0|0|0)
- 1:   karyosome formation [GO:0030717](0|0) (2|0|0)
- 1:   luteinizing hormone signaling pathway involved in ovarian follicle development [GO:0035471](0|0) (0|0|0)
- 1:   maintenance of floral organ identity [GO:0048497](0|0) (2|1|0)
- 1:   manchette assembly [GO:1905198](0|0) (0|0|0)
- 1:   mesenchymal smoothened signaling pathway involved in prostate gland development [GO:0060783](0|0) (0|0|0)
- 1:   mitotic cell cycle G1 arrest in response to pheromone [GO:0000751](0|0) (0|0|0)
- 1:   negative regulation of progesterone biosynthesis involved in luteolysis [GO:0061363](0|0) (0|0|0)
- 1:   nurse cell nucleus anchoring [GO:0007302](0|0) (4|2|1)
- 1:   oocyte localization involved in germarium-derived egg chamber formation [GO:0030720](0|0) (3|1|0)
- 1:   oocyte microtubule cytoskeleton polarization [GO:0008103](0|0) (4|0|0)
- 1:   peptide mating pheromone maturation involved in conjugation with cellular fusion [GO:0071432](0|0) (0|0|0)
- 1:   peptidyl-serine phosphorylation involved in acrosome reaction [GO:0060477](0|0) (0|0|0)
- 1:   pole plasm protein localization [GO:0007318](0|0) (2|0|0)
- 1:   pollen tube guidance [GO:0010183](0|0) (0|0|0)
- 1:   positive regulation of flagellated sperm motility involved in capacitation [GO:0060474](1|1) (1|0|0)
- 1:   positive regulation of transcription involved in egg activation [GO:0060469](0|0) (0|0|0)
- 1:   pronuclear fusion [GO:0007344](0|0) (0|0|0)
- 1:   pronuclear migration [GO:0035046](0|0) (0|0|0)
- 1:   regulation of transcription from RNA polymerase II promoter involved in spermatogenesis [GO:1902064](0|0) (0|0|0)
- 1:   secondary cell wall biogenesis involved in seed trichome differentiation [GO:0090379](0|0) (2|0|0)
- 1:   seed oilbody biogenesis [GO:0010344](0|0) (0|0|0)
- 1:   sex determination, somatic-gonadal interaction [GO:0007543](0|0) (0|0|0)
- 1:   sperm aster formation [GO:0035044](0|0) (0|0|0)
- 1:   spermatid nucleus elongation [GO:0007290](0|0) (0|0|0)
- 1:   spermatogenesis, exchange of chromosomal proteins [GO:0035093](0|0) (8|4|2)
- 1:   strand invasion involved in gene conversion at mating-type locus [GO:0034636](0|0) (0|0|0)
- 1:   transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ ab [GO:0060869](0|0) (0|0|0)


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
14-3-3 protein0.000028350.0008565Direct
4-helical cytokines0.00011370.000002108Direct
AF0104/ALDC/Ptd012-like0.00023780.0004104Direct
ARM repeat0.0000098140.000000001708Direct
Bcl-2 inhibitors of programmed cell death0.000000016370.000000328Direct
Cadherin-like0.00000000051160.0002224Direct
Cu,Zn superoxide dismutase-like0.0000000000000031440.000000005286Direct
Cystine-knot cytokines0.000000013250.0000000000002091Direct
Defensin-like0.00000000018530.000078Direct
DNA topoisomerase IV, alpha subunit0.00001440.00000000006256Direct
Fertilization protein00Direct
Heme-dependent peroxidases0.00056220.0006229Direct
Homeodomain-like0.000082880Direct
Inhibitor of apoptosis (IAP) repeat0.0000840.0000000893Direct
P-loop containing nucleoside triphosphate hydrolases0.00024510.00000006623Direct
PEBP-like0.0000000056840.0005272Direct
PHP14-like00.000000000000007296Direct
Profilin (actin-binding protein)0.000000040360.00002181Direct
Protein kinase-like (PK-like)0.00000000000014760Direct
Tubulin C-terminal domain-like0.0000039890.000000000000003734Direct
Metalloproteases ("zincins"), catalytic domain0.40520.0000002498Inherited
Histone-fold0.0043370.08022Inherited
WD40 repeat-like0.000050930.001377Inherited
Annexin0.00015130.1173Inherited
Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin0.0000009220.01923Inherited
NagB/RpiA/CoA transferase-like0.0099760.08652Inherited
Plant invertase/pectin methylesterase inhibitor0.0001160.001498Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.017870.4077Inherited
Lysozyme-like0.0022760.2167Inherited
Terpenoid synthases0.05980.8226Inherited
NAD(P)-binding Rossmann-fold domains11Inherited
Trypsin-like serine proteases0.022850.2423Inherited
Phospholipase D/nuclease0.000000000036440.1812Inherited


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
AF0104-like0.000003850.0000299Direct
Bcl-2 inhibitors of programmed cell death0.00000012270.000001139Direct
C-type lysozyme0.000046550.0007426Direct
Cu,Zn superoxide dismutase-like0.000000000000039250.00000001918Direct
Defensin00.0000000619Direct
DNA topoisomerase IV, alpha subunit0.000023010.0000000001321Direct
Fertilization protein00Direct
Gonadodropin/Follitropin0.000000002050.0000087Direct
Homeodomain0.00013430.00000000001808Direct
IF2B-like0.00057220.000149Direct
Inhibitor of apoptosis (IAP) repeat0.00017820.0000002737Direct
Janus/Ocnus00Direct
Long-chain cytokines0.0000000013340.000000000004496Direct
Nuclease0.0000000000071920.000000004443Direct
Phosphatidylethanolamine binding protein0.00000000011970.00002296Direct
Plant lipid-transfer and hydrophobic proteins0.000000017220.0000539Direct
Profilin (actin-binding protein)0.00000015780.00003872Direct
Protein kinases, catalytic subunit0.0000000000000011680Direct
Pumilio repeat0.000011430.0001054Direct
Tubulin, C-terminal domain0.0000058170.00000000000003226Direct
RecA protein-like (ATPase-domain)0.0039470.00004087Inherited
Astacin0.0084070.05749Inherited
G proteins0.00000002111Inherited
Armadillo repeat0.0000025910.01151Inherited
WD40-repeat0.00054810.03115Inherited
Annexin0.00041560.1571Inherited
CCP-like0.00088720.04091Inherited
Plastocyanin/azurin-like0.000055770.01978Inherited
Nucleosome core histones0.090640.2603Inherited
14-3-3 protein0.000073850.001507Inherited
Carboxylesterase0.021090.3275Inherited
Isoprenyl diphosphate synthases0.022240.0834Inherited
Tyrosine-dependent oxidoreductases11Inherited
Eukaryotic proteases0.039420.03901Inherited
AlkB-like0.000037080.00421Inherited
Germin/Seed storage 7S protein0.0030860.003688Inherited
Papain-like0.000080710.1276Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this GO term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Protein kinase-like (PK-like)0Direct
Tudor/PWWP/MBT0Direct
Cysteine-rich DNA binding domain, (DM domain)0Direct
Pseudo ankyrin repeat-like0Direct
Fertilization protein0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
PAZ domain0Direct
HMG-box0Direct
SRF-like0Direct
Homeodomain-like0Direct
Chromo domain-like9.676e-16Direct
Tubulin C-terminal domain-like0.000000000000001898Direct
PHP14-like0.000000000000003737Direct
The spindle assembly checkpoint protein mad20.000000000000003737Direct
DNA repair protein MutS, domain III0.00000000000001886Direct
Cystine-knot cytokines0.0000000000001121Direct
dsRNA-binding domain-like0.0000000000002141Direct
Cyclin-like0.00000000000027Direct
Nuclear receptor ligand-binding domain0.0000000000003427Direct
ABC transporter transmembrane region0.000000000001083Direct
DNA-binding pseudobarrel domain0.000000000001508Direct
L domain-like0.000000000003435Direct
Tubulin nucleotide-binding domain-like0.000000000006818Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0.000000000007963Direct
Rad51 N-terminal domain-like0.00000000001109Direct
Glucocorticoid receptor-like (DNA-binding domain)0.00000000001799Direct
DNA topoisomerase IV, alpha subunit0.00000000003574Direct
Blood coagulation inhibitor (disintegrin)0.0000000003555Direct
BRK domain-like0.0000000004078Direct
RNA-binding domain, RBD0.0000000007542Direct
ARM repeat0.000000001009Direct
HLH, helix-loop-helix DNA-binding domain0.000000001263Direct
Cu,Zn superoxide dismutase-like0.00000000317Direct
DNA mismatch repair protein MutL0.00000001264Direct
Polo-box domain0.00000001765Direct
p53-like transcription factors0.00000001787Direct
Bromodomain0.00000002368Direct
STAT0.0000000344Direct
P-loop containing nucleoside triphosphate hydrolases0.00000004097Direct
SMAD MH1 domain0.00000005295Direct
Inhibitor of apoptosis (IAP) repeat0.00000005537Direct
FYVE/PHD zinc finger0.00000005942Direct
Amyloid beta a4 protein copper binding domain (domain 2)0.000000091Direct
Metalloproteases ("zincins"), catalytic domain0.0000001569Direct
Crisp domain-like0.000000179Direct
SMAD/FHA domain0.0000001927Direct
Bcl-2 inhibitors of programmed cell death0.0000002068Direct
HR1 repeat0.0000003606Direct
A heparin-binding domain0.0000004566Direct
ACT-like0.0000005289Direct
Spectrin repeat0.0000005392Direct
Smc hinge domain0.00000077Direct
Cullin repeat-like0.0000008994Direct
Transcription factor STAT-4 N-domain0.0000009778Direct
ARID-like0.000001077Direct
4-helical cytokines0.000001362Direct
BRCA2 helical domain0.000001698Direct
BRCA2 tower domain0.000001698Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0.000001769Direct
Insulin-like0.000001998Direct
TAZ domain0.000007243Direct
SAM/Pointed domain0.00001292Direct
NAC domain0.00001444Direct
Profilin (actin-binding protein)0.00001457Direct
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain0.00001654Direct
POZ domain0.00001708Direct
PYP-like sensor domain (PAS domain)0.00001801Direct
Cullin homology domain0.00002055Direct
Dimerization cofactor of HNF-1 alpha0.00002991Direct
MAST3 pre-PK domain-like0.00003102Direct
Stathmin0.00004469Direct
YWTD domain0.00005174Direct
Defensin-like0.00005311Direct
SBT domain0.00005837Direct
beta-beta-alpha zinc fingers0.00007159Direct
SH2 domain0.0000745Direct
Kix domain of CBP (creb binding protein)0.00008813Direct
DNA repair protein MutS, domain II0.00008832Direct
Nuclear receptor coactivator interlocking domain0.0001206Direct
Myosin S1 fragment, N-terminal domain0.0001206Direct
Cadherin-like0.0001539Direct
G protein-binding domain0.0001637Direct
Integrin domains0.0001788Direct
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)0.000184Direct
BAR/IMD domain-like0.0001873Direct
AF0104/ALDC/Ptd012-like0.0002875Direct
Formin homology 2 domain (FH2 domain)0.0003581Direct
PEBP-like0.0003707Direct
Heme-dependent peroxidases0.0004395Direct
FAS1 domain0.0004497Direct
Phenylalanine zipper0.0004611Direct
Snake toxin-like0.0005429Direct
14-3-3 protein0.0006075Direct
DNA repair protein MutS, domain I0.0006122Direct
Restriction endonuclease-like0.0006896Direct
Tetraspanin0.0009842Direct
WD40 repeat-like0.0009857Direct
HRDC-like0.5648Inherited
Nucleotide-diphospho-sugar transferases0.6623Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.1829Inherited
Translation proteins1Inherited
Cupredoxins1Inherited
Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin0.01454Inherited
Glutamine synthetase, N-terminal domain0.05167Inherited
Annexin0.09341Inherited
PHL pollen allergen0.03069Inherited
Barwin-like endoglucanases0.386Inherited
Glutamine synthetase/guanido kinase0.7203Inherited
Aquaporin-like0.3451Inherited
Arabinanase/levansucrase/invertase0.7333Inherited
Thiolase-like0.9615Inherited
Serpins0.07427Inherited
Immunoglobulin0.05553Inherited
Complement control module/SCR domain0.9432Inherited
E set domains0.9935Inherited
Prokaryotic type I DNA topoisomerase0.007938Inherited
Sec63 N-terminal domain-like0.001254Inherited
RuvA domain 2-like0.001195Inherited
Plant invertase/pectin methylesterase inhibitor0.001075Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.7806Inherited
Pectin lyase-like0.4325Inherited
YhbY-like0.06583Inherited
alpha/beta-Hydrolases1Inherited
Phospholipase D/nuclease0.1466Inherited
Succinyl-CoA synthetase domains0.4334Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
SpoIIaa-like0.1707Inherited
Oxysterol-binding protein-like0.1556Inherited
UBC-like0.5463Inherited
Nucleoside diphosphate kinase, NDK0.6902Inherited
Phospholipase A2, PLA20.01871Inherited
Rhomboid-like0.5341Inherited
eIF4e-like0.6683Inherited
RNI-like0.9954Inherited
Quinoprotein alcohol dehydrogenase-like0.9674Inherited
EGF/Laminin0.006624Inherited
Ubiquitin-like0.5956Inherited
Activating enzymes of the ubiquitin-like proteins0.1717Inherited
E2F-DP heterodimerization region0.01645Inherited
Rap/Ran-GAP0.1865Inherited
Bet v1-like0.1149Inherited
Class II aaRS and biotin synthetases1Inherited
Nucleotidylyl transferase0.8542Inherited
Leucine zipper domain0.005849Inherited
SET domain0.02529Inherited
Multidrug resistance efflux transporter EmrE1Inherited
F-box domain1Inherited
DNase I-like0.9369Inherited
Cysteine proteinases1Inherited
Hemopexin-like domain0.06688Inherited
PGBD-like0.09829Inherited
Trimeric LpxA-like enzymes0.1112Inherited
C-type lectin-like1Inherited
CAD & PB1 domains0.001073Inherited
Caspase-like0.1813Inherited
Family A G protein-coupled receptor-like0.8359Inherited
NagB/RpiA/CoA transferase-like0.06824Inherited
Toll/Interleukin receptor TIR domain0.5762Inherited
Glycoside hydrolase/deacetylase1Inherited
UDP-Glycosyltransferase/glycogen phosphorylase1Inherited
(Trans)glycosidases1Inherited
PX domain0.9405Inherited
HIT/MYND zinc finger-like0.05074Inherited
FKBP-like0.4363Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
Putative DNA-binding domain0.033Inherited
DEATH domain1Inherited
Sema domain0.4781Inherited
Plexin repeat0.07625Inherited
RING/U-box0.7389Inherited
Histone-fold0.06316Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
t-snare proteins0.08047Inherited
Hedgehog/intein (Hint) domain0.005108Inherited
Hedgehog/DD-peptidase0.003487Inherited
Multidrug efflux transporter AcrB transmembrane domain0.01462Inherited
Spermadhesin, CUB domain0.7171Inherited
Riboflavin synthase domain-like0.9009Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.9244Inherited
GTPase activation domain, GAP1Inherited
SH3-domain0.0127Inherited
Cysteine-rich domain0.02296Inherited
Calponin-homology domain, CH-domain0.006719Inherited
(Phosphotyrosine protein) phosphatases II0.0922Inherited
Colipase-like0.003206Inherited
Zn-dependent exopeptidases1Inherited
PK C-terminal domain-like0.3328Inherited
Phosphoenolpyruvate/pyruvate domain0.9785Inherited
RmlC-like cupins1Inherited
PK beta-barrel domain-like0.8818Inherited
Clavaminate synthase-like0.5185Inherited
RNase III domain-like0.00946Inherited
PABC (PABP) domain0.03212Inherited
cAMP-binding domain-like0.4526Inherited
DNA-binding domain0.001257Inherited
WRKY DNA-binding domain0.04278Inherited
ValRS/IleRS/LeuRS editing domain0.2855Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.7194Inherited
Calpain large subunit, middle domain (domain III)0.05723Inherited
Voltage-gated potassium channels1Inherited
Trypsin-like serine proteases0.1986Inherited
Nucleoplasmin-like core domain0.004125Inherited
GroEL apical domain-like0.07166Inherited
PR-1-like0.01283Inherited
Lysozyme-like0.1765Inherited
Protease propeptides/inhibitors0.4671Inherited
Subtilisin-like0.1251Inherited
Trefoil0.05074Inherited
GroEL-intermediate domain like0.0944Inherited
GroEL equatorial domain-like0.1178Inherited
Cystatin/monellin0.622Inherited
Terpenoid synthases0.7254Inherited
UBA-like0.8067Inherited
Ran binding protein zinc finger-like0.9695Inherited
BPTI-like0.016Inherited
HD-domain/PDEase-like1Inherited
Fibrinogen C-terminal domain-like0.6578Inherited
Integrin beta tail domain0.02861Inherited
Kringle-like0.1001Inherited
Growth factor receptor domain0.5864Inherited
vWA-like1Inherited
Frizzled cysteine-rich domain0.01283Inherited
Alpha-macroglobulin receptor domain0.2494Inherited
Cytochrome P4500.8609Inherited
SRCR-like0.9857Inherited
MHC antigen-recognition domain1Inherited
Cytokine0.3467Inherited
Ras GEF0.6489Inherited
Ribonuclease H-like0.006536Inherited
PLC-like phosphodiesterases0.1399Inherited
C-terminal domain of PLC-beta0.6584Inherited
EF-hand1Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.004581Inherited
PH domain-like0.02697Inherited
Nucleotide cyclase0.7363Inherited
N-terminal domain of adenylylcyclase associated protein, CAP0.00503Inherited
C-terminal domain of adenylylcyclase associated protein0.02673Inherited
GAS2 domain-like0.2354Inherited
SAICAR synthase-like0.04634Inherited
Kazal-type serine protease inhibitors0.4868Inherited
N-terminal domain of cbl (N-cbl)0.001109Inherited
Second domain of FERM0.6232Inherited
L27 domain0.0428Inherited
alpha-catenin/vinculin-like0.1423Inherited
I/LWEQ domain0.0305Inherited
Actin depolymerizing proteins0.2377Inherited
CRAL/TRIO domain0.01845Inherited
SOCS box-like0.483Inherited
A middle domain of Talin 10.002956Inherited
PDZ domain-like0.01013Inherited
beta-sandwich domain of Sec23/240.06586Inherited
TPR-like1Inherited
A DNA-binding domain in eukaryotic transcription factors0.08409Inherited
KA1-like0.03456Inherited
SAP domain0.1709Inherited
Ypt/Rab-GAP domain of gyp1p0.3672Inherited
Chaperone J-domain0.7053Inherited
Eukaryotic type KH-domain (KH-domain type I)0.01379Inherited
NAP-like0.09867Inherited
Staphylococcal nuclease0.1338Inherited
Fibronectin type III0.0501Inherited
Subunits of heterodimeric actin filament capping protein Capz0.03069Inherited
NAD kinase/diacylglycerol kinase-like0.8137Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.3429Inherited
TSP-1 type 1 repeat0.7315Inherited
DBL homology domain (DH-domain)0.03626Inherited
BRCT domain0.001656Inherited
Regulator of G-protein signaling, RGS0.0126Inherited
Lamin A/C globular tail domain0.02389Inherited
Ribosomal protein S5 domain 2-like1Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.4912Inherited
Ankyrin repeat0.09477Inherited
DNA/RNA polymerases1Inherited
Mago nashi protein0.004659Inherited
Orange domain-like0.1188Inherited
"Winged helix" DNA-binding domain0.1294Inherited
SPOC domain-like0.005685Inherited
lambda repressor-like DNA-binding domains1Inherited
Galactose-binding domain-like0.7976Inherited
Kelch motif0.9034Inherited
Integrin alpha N-terminal domain0.06431Inherited
HAD-like1Inherited
Transducin (alpha subunit), insertion domain0.9862Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.8687Inherited
Acid proteases0.77Inherited
Calcium ATPase, transduction domain A0.9772Inherited
Calcium ATPase, transmembrane domain M1Inherited
DNA polymerase beta, N-terminal domain-like0.1055Inherited
Nucleic acid-binding proteins0.004119Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48097,57889
  • 48097 - Regulator of G-protein signaling, RGS
  • 57889 - Cysteine-rich domain
  • 0Direct
    49899,54001
  • 49899 - Concanavalin A-like lectins/glucanases
  • 54001 - Cysteine proteinases
  • 0Direct
    47769,140860
  • 47769 - SAM/Pointed domain
  • 140860 - Pseudo ankyrin repeat-like
  • 0Direct
    81995,55785
  • 81995 - beta-sandwich domain of Sec23/24
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    103652,50729
  • 103652 - G protein-binding domain
  • 50729 - PH domain-like
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    48403,47769
  • 48403 - Ankyrin repeat
  • 47769 - SAM/Pointed domain
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00000000000001092Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00000000000006572Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.0000000000001154Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0000000000003952Direct
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0.0000000000005464Direct
    47794,52540
  • 47794 - Rad51 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0000000000005933Direct
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.00000000006068Direct
    48403,48452
  • 48403 - Ankyrin repeat
  • 48452 - TPR-like
  • 0.00000000008407Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0000000003171Direct
    57362,109843
  • 57362 - BPTI-like
  • 109843 - CAPPD, an extracellular domain of amyloid beta A4 protein
  • 0.000000003746Direct
    52047,52058
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 0.000000004736Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.00000001032Direct
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.00000001451Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000001774Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000001774Direct
    55797,57546
  • 55797 - PR-1-like
  • 57546 - Crisp domain-like
  • 0.00000004211Direct
    48403,140860
  • 48403 - Ankyrin repeat
  • 140860 - Pseudo ankyrin repeat-like
  • 0.00000005882Direct
    56491,89811
  • 56491 - A heparin-binding domain
  • 89811 - Amyloid beta a4 protein copper binding domain (domain 2)
  • 0.000000091Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.0000000924Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.000000154Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0.0000001828Direct
    55961,55961
  • 55961 - Bet v1-like
  • 55961 - Bet v1-like
  • 0.0000002743Direct
    57850,57933
  • 57850 - RING/U-box
  • 57933 - TAZ domain
  • 0.0000003557Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0000008041Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0000008185Direct
    50249,81878
  • 50249 - Nucleic acid-binding proteins
  • 81878 - BRCA2 tower domain
  • 0.000001698Direct
    81872,50249
  • 81872 - BRCA2 helical domain
  • 50249 - Nucleic acid-binding proteins
  • 0.000001698Direct
    81878,50249
  • 81878 - BRCA2 tower domain
  • 50249 - Nucleic acid-binding proteins
  • 0.000001698Direct
    48371,49785
  • 48371 - ARM repeat
  • 49785 - Galactose-binding domain-like
  • 0.000001954Direct
    63748,48371
  • 63748 - Tudor/PWWP/MBT
  • 48371 - ARM repeat
  • 0.000002451Direct
    109885,47220
  • 109885 - I/LWEQ domain
  • 47220 - alpha-catenin/vinculin-like
  • 0.000002451Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0.000002541Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.000002915Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.000004404Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.000009429Direct
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.00001129Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.00001224Direct
    52058,56112
  • 52058 - L domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00001486Direct
    109925,50978
  • 109925 - Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain
  • 50978 - WD40 repeat-like
  • 0.00001654Direct
    160481,52540
  • 160481 - BRK domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00001654Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00001758Direct
    63825,49265
  • 63825 - YWTD domain
  • 49265 - Fibronectin type III
  • 0.00002893Direct
    53150,48334
  • 53150 - DNA repair protein MutS, domain II
  • 48334 - DNA repair protein MutS, domain III
  • 0.00003726Direct
    101936,101936
  • 101936 - DNA-binding pseudobarrel domain
  • 101936 - DNA-binding pseudobarrel domain
  • 0.00003854Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00003877Direct
    69572,69572
  • 69572 - Activating enzymes of the ubiquitin-like proteins
  • 69572 - Activating enzymes of the ubiquitin-like proteins
  • 0.00004911Direct
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.00005058Direct
    51161,48371
  • 51161 - Trimeric LpxA-like enzymes
  • 48371 - ARM repeat
  • 0.00007416Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00007571Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0001022Direct
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.0001053Direct
    46966,50044
  • 46966 - Spectrin repeat
  • 50044 - SH3-domain
  • 0.0001206Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0.0001206Direct
    56112,54236
  • 56112 - Protein kinase-like (PK-like)
  • 54236 - Ubiquitin-like
  • 0.0001244Direct
    49265,63825
  • 49265 - Fibronectin type III
  • 63825 - YWTD domain
  • 0.0001244Direct
    69065,54768
  • 69065 - RNase III domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.0001478Direct
    47212,56112
  • 47212 - FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
  • 56112 - Protein kinase-like (PK-like)
  • 0.000184Direct
    69065,69065
  • 69065 - RNase III domain-like
  • 69065 - RNase III domain-like
  • 0.0001939Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.0002198Direct
    52058,52047
  • 52058 - L domain-like
  • 52047 - RNI-like
  • 0.0002243Direct
    63501,57424
  • 63501 - Frizzled cysteine-rich domain
  • 57424 - LDL receptor-like module
  • 0.000234Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.000259Direct
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.0002612Direct
    56112,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 0.000374Direct
    49562,50729
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 50729 - PH domain-like
  • 0.000431Direct
    53335,53335
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0.0004727Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.0004798Direct
    54534,48452
  • 54534 - FKBP-like
  • 48452 - TPR-like
  • 0.0004912Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0005146Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0006891Direct
    56112,52799
  • 56112 - Protein kinase-like (PK-like)
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.000721Direct
    50729,74788
  • 50729 - PH domain-like
  • 74788 - Cullin repeat-like
  • 0.000721Direct
    46565,48371
  • 46565 - Chaperone J-domain
  • 48371 - ARM repeat
  • 0.000721Direct
    49899,55486
  • 49899 - Concanavalin A-like lectins/glucanases
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0007278Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0.0008621Direct
    54171,54171
  • 54171 - DNA-binding domain
  • 54171 - DNA-binding domain
  • 0.001092Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.02238Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.176Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.9454Inherited
    54368,55931
  • 54368 - Glutamine synthetase, N-terminal domain
  • 55931 - Glutamine synthetase/guanido kinase
  • 0.05167Inherited
    50685,49590
  • 50685 - Barwin-like endoglucanases
  • 49590 - PHL pollen allergen
  • 0.03069Inherited
    75005,49899
  • 75005 - Arabinanase/levansucrase/invertase
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.162Inherited
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0.2931Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.6913Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.03456Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.06345Inherited
    51101,51101
  • 51101 - Mannose-binding lectins
  • 51101 - Mannose-binding lectins
  • 0.00679Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2382Inherited
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.009065Inherited
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0.1323Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.2043Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.008131Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.01645Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.03158Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.01715Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.3888Inherited
    53448,51161
  • 53448 - Nucleotide-diphospho-sugar transferases
  • 51161 - Trimeric LpxA-like enzymes
  • 0.005298Inherited
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0.02861Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.2253Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.5304Inherited
    50729,50044
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.1055Inherited
    49879,56112
  • 49879 - SMAD/FHA domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.009766Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.09436Inherited
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0.009936Inherited
    52058,56219
  • 52058 - L domain-like
  • 56219 - DNase I-like
  • 0.004356Inherited
    50044,46966
  • 50044 - SH3-domain
  • 46966 - Spectrin repeat
  • 0.001753Inherited
    54236,48366
  • 54236 - Ubiquitin-like
  • 48366 - Ras GEF
  • 0.0169Inherited
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0.003104Inherited
    50405,50405
  • 50405 - Actin-crosslinking proteins
  • 50405 - Actin-crosslinking proteins
  • 0.01138Inherited
    57716,50156
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 50156 - PDZ domain-like
  • 0.003206Inherited
    57190,57190
  • 57190 - Colipase-like
  • 57190 - Colipase-like
  • 0.002323Inherited
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0.02721Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.1818Inherited
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0.5246Inherited
    50800,51621
  • 50800 - PK beta-barrel domain-like
  • 51621 - Phosphoenolpyruvate/pyruvate domain
  • 0.2693Inherited
    51621,52935
  • 51621 - Phosphoenolpyruvate/pyruvate domain
  • 52935 - PK C-terminal domain-like
  • 0.29Inherited
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.005548Inherited
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0.2855Inherited
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0.1934Inherited
    54403,54403
  • 54403 - Cystatin/monellin
  • 54403 - Cystatin/monellin
  • 0.009012Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.08966Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.141Inherited
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0.2496Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.0104Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.05376Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.066Inherited
    55486,57440
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57440 - Kringle-like
  • 0.002184Inherited
    81296,48239
  • 81296 - E set domains
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 0.009766Inherited
    57424,56487
  • 57424 - LDL receptor-like module
  • 56487 - SRCR-like
  • 0.03204Inherited
    56487,50494
  • 56487 - SRCR-like
  • 50494 - Trypsin-like serine proteases
  • 0.335Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.1562Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.8407Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4788Inherited
    47473,143575
  • 47473 - EF-hand
  • 143575 - GAS2 domain-like
  • 0.1453Inherited
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.04689Inherited
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0.1294Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.03524Inherited
    55550,57850
  • 55550 - SH2 domain
  • 57850 - RING/U-box
  • 0.001092Inherited
    47668,47473
  • 47668 - N-terminal domain of cbl (N-cbl)
  • 47473 - EF-hand
  • 0.001092Inherited
    47473,55550
  • 47473 - EF-hand
  • 55550 - SH2 domain
  • 0.00157Inherited
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.1087Inherited
    50044,51695
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 0.03204Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.4132Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.1712Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.3518Inherited
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0.6178Inherited
    109880,109885
  • 109880 - A middle domain of Talin 1
  • 109885 - I/LWEQ domain
  • 0.002956Inherited
    109885,109885
  • 109885 - I/LWEQ domain
  • 109885 - I/LWEQ domain
  • 0.003898Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.0649Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.5785Inherited
    57196,48113
  • 57196 - EGF/Laminin
  • 48113 - Heme-dependent peroxidases
  • 0.01186Inherited
    103657,50044
  • 103657 - BAR/IMD domain-like
  • 50044 - SH3-domain
  • 0.08289Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1506Inherited
    47095,47095
  • 47095 - HMG-box
  • 47095 - HMG-box
  • 1Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.03962Inherited
    54791,54791
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 0.001728Inherited
    55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0.005765Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1015Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.04826Inherited
    50199,63748
  • 50199 - Staphylococcal nuclease
  • 63748 - Tudor/PWWP/MBT
  • 0.01243Inherited
    63748,50199
  • 63748 - Tudor/PWWP/MBT
  • 50199 - Staphylococcal nuclease
  • 0.01481Inherited
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0.01243Inherited
    48403,56112
  • 48403 - Ankyrin repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.00186Inherited
    46689,46689
  • 46689 - Homeodomain-like
  • 46689 - Homeodomain-like
  • 0.002421Inherited
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.5962Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.1122Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.00284Inherited
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.0369Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.001874Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.009322Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1765Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.9862Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.9132Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.9397Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    103652,50729,57889
  • 103652 - G protein-binding domain
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    49899,54001,49758
  • 49899 - Concanavalin A-like lectins/glucanases
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    48403,47769,140860
  • 48403 - Ankyrin repeat
  • 47769 - SAM/Pointed domain
  • 140860 - Pseudo ankyrin repeat-like
  • 0Direct
    52058,57184,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    63748,48371,49785
  • 63748 - Tudor/PWWP/MBT
  • 48371 - ARM repeat
  • 49785 - Galactose-binding domain-like
  • 0Direct
    52058,52047,52058
  • 52058 - L domain-like
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 0.000000008607Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000000883Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0000005374Direct
    54768,54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.000001294Direct
    50249,81878,50249
  • 50249 - Nucleic acid-binding proteins
  • 81878 - BRCA2 tower domain
  • 50249 - Nucleic acid-binding proteins
  • 0.000001698Direct
    81878,50249,50249
  • 81878 - BRCA2 tower domain
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.000001698Direct
    81872,50249,81878
  • 81872 - BRCA2 helical domain
  • 50249 - Nucleic acid-binding proteins
  • 81878 - BRCA2 tower domain
  • 0.000001698Direct
    46689,46689,46689
  • 46689 - Homeodomain-like
  • 46689 - Homeodomain-like
  • 46689 - Homeodomain-like
  • 0.000001874Direct
    52047,52058,52058
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.000001954Direct
    109885,109885,47220
  • 109885 - I/LWEQ domain
  • 109885 - I/LWEQ domain
  • 47220 - alpha-catenin/vinculin-like
  • 0.000002451Direct
    109885,47220,47220
  • 109885 - I/LWEQ domain
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.000002451Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.000005543Direct
    57850,57850,57933
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57933 - TAZ domain
  • 0.000009303Direct
    109885,109885,109885
  • 109885 - I/LWEQ domain
  • 109885 - I/LWEQ domain
  • 109885 - I/LWEQ domain
  • 0.00001005Direct
    160481,52540,52540
  • 160481 - BRK domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00001654Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00002626Direct
    63825,49265,63825
  • 63825 - YWTD domain
  • 49265 - Fibronectin type III
  • 63825 - YWTD domain
  • 0.00002893Direct
    69065,69065,54768
  • 69065 - RNase III domain-like
  • 69065 - RNase III domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.00003102Direct
    53150,48334,52540
  • 53150 - DNA repair protein MutS, domain II
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00003726Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00003877Direct
    50044,46966,46966
  • 50044 - SH3-domain
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.00007416Direct
    53448,51161,48371
  • 53448 - Nucleotide-diphospho-sugar transferases
  • 51161 - Trimeric LpxA-like enzymes
  • 48371 - ARM repeat
  • 0.00007416Direct
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.00007983Direct
    101936,101936,101936
  • 101936 - DNA-binding pseudobarrel domain
  • 101936 - DNA-binding pseudobarrel domain
  • 101936 - DNA-binding pseudobarrel domain
  • 0.0001097Direct
    46966,46966,50044
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 50044 - SH3-domain
  • 0.0001206Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.000125Direct
    50249,50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.0001478Direct
    63501,57424,57424
  • 63501 - Frizzled cysteine-rich domain
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.000234Direct
    57424,57424,56487
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 56487 - SRCR-like
  • 0.000234Direct
    56112,82615,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0.000374Direct
    56112,52799,49562
  • 56112 - Protein kinase-like (PK-like)
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.000431Direct
    47473,51695,49562
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.0004732Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0005318Direct
    52047,52058,56112
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.000696Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.1625Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.009174Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.0208Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.01299Inherited
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2116Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.3436Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.6407Inherited
    47370,47370,47370
  • 47370 - Bromodomain
  • 47370 - Bromodomain
  • 47370 - Bromodomain
  • 0.004659Inherited
    48065,50729,50044
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.04462Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 1Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001033Inherited
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0.003379Inherited
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.01746Inherited
    46966,50044,46966
  • 46966 - Spectrin repeat
  • 50044 - SH3-domain
  • 46966 - Spectrin repeat
  • 0.001753Inherited
    50405,50405,50405
  • 50405 - Actin-crosslinking proteins
  • 50405 - Actin-crosslinking proteins
  • 50405 - Actin-crosslinking proteins
  • 0.01138Inherited
    57716,57716,50156
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 50156 - PDZ domain-like
  • 0.003206Inherited
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4913Inherited
    50800,51621,52935
  • 50800 - PK beta-barrel domain-like
  • 51621 - Phosphoenolpyruvate/pyruvate domain
  • 52935 - PK C-terminal domain-like
  • 0.2693Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1729Inherited
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.05073Inherited
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.1347Inherited
    50156,50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.1412Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01646Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.4083Inherited
    47090,55486,57440
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57440 - Kringle-like
  • 0.002184Inherited
    55486,57440,57440
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.002184Inherited
    57424,56487,50494
  • 57424 - LDL receptor-like module
  • 56487 - SRCR-like
  • 50494 - Trypsin-like serine proteases
  • 0.03204Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.09435Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.151Inherited
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0.1898Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.3355Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.2528Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1564Inherited
    47668,47473,55550
  • 47668 - N-terminal domain of cbl (N-cbl)
  • 47473 - EF-hand
  • 55550 - SH2 domain
  • 0.001092Inherited
    47473,55550,57850
  • 47473 - EF-hand
  • 55550 - SH2 domain
  • 57850 - RING/U-box
  • 0.001092Inherited
    50044,51695,49562
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.03204Inherited
    109880,109885,109885
  • 109880 - A middle domain of Talin 1
  • 109885 - I/LWEQ domain
  • 109885 - I/LWEQ domain
  • 0.002956Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01186Inherited
    54791,54791,54791
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 0.02057Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.002273Inherited
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03449Inherited
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.03449Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.009322Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.8787Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
    Plot tree as:   Download Newick format tree:   Browsing in Tree_gateway:
    (show help)