SUPERFAMILY 1.75 HMM library and genome assignments server

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Biological Process (BP): multicellular organismal process

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Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ 1:   biological_process [GO:0008150] <24>
0:   multicellular organismal process [GO:0032501] <6>(93|111) (573|658|432)
- 1:   single-multicellular organism process [GO:0044707] <74>(83|99) (548|635|419)
- 1:   multi-multicellular organism process [GO:0044706] <9>(3|3) (44|22|16)
- 1:   system process [GO:0003008] <9>(12|13) (189|144|86)
- 1:   multicellular organism reproduction [GO:0032504] <3>(20|21) (213|135|54)
- 1:   multicellular organismal macromolecule catabolic process [GO:0044266] <2>(0|0) (1|0|0)
- 1:   multicellular organismal biosynthetic process [GO:0044274](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
4-helical cytokines0.00000000000047230.000001322Direct
BPTI-like0.00026180.00000001972Direct
Cadherin-like0.0000036450Direct
Core binding factor beta, CBF0.00000002430.0000005551Direct
Cystine-knot cytokines0.00000065570Direct
Cytokine00Direct
E set domains0.00064840.00000001967Direct
EF-hand0.000000000035410Direct
Family A G protein-coupled receptor-like00Direct
Fibronectin type III0.00015950Direct
HLH, helix-loop-helix DNA-binding domain00Direct
Homeodomain-like0.00000024660Direct
Insect pheromone/odorant-binding proteins00Direct
Lipocalins00.00003383Direct
Mitochondrial cytochrome c oxidase subunit VIIb0.0000015120.00009755Direct
Myosin S1 fragment, N-terminal domain0.00052870.00006237Direct
p53-like transcription factors0.00017210Direct
PDZ domain-like0.00068750Direct
Protein kinase-like (PK-like)00Direct
RNase A-like0.0000000013520.0003825Direct
Sema domain0.0000015120Direct
Serpins0.000000000030270.00004966Direct
SET domain0.000025680.0000001652Direct
Spectrin repeat0.00000015150Direct
Spermadhesin, CUB domain00Direct
SRF-like0.0003520Direct
Stathmin00Direct
Tropomyosin0.00011310.0003325Direct
Trypsin-like serine proteases0.0000000000000031440.000004821Direct
Tubulin C-terminal domain-like0.0006040.0007753Direct
Mitochondrial carrier0.017421Inherited
S-adenosyl-L-methionine-dependent methyltransferases11Inherited
NAD(P)-binding Rossmann-fold domains11Inherited
PEBP-like0.0019360.9934Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.00052871Inherited
(Phosphotyrosine protein) phosphatases II0.072870Inherited
alpha/beta-Hydrolases11Inherited
(Trans)glycosidases0.37391Inherited
Immunoglobulin0.1590Inherited
Metallothionein0.13421Inherited
ALDH-like0.84721Inherited
Caspase-like0.00000000061650.01365Inherited
Calcium-dependent phosphotriesterase0.65811Inherited
Globin-like0.0043251Inherited
Preprotein translocase SecY subunit0.0000001460.001387Inherited
beta-beta-alpha zinc fingers0.0057450Inherited
Heme-dependent peroxidases0.041510.00001402Inherited
Annexin0.00018340.6878Inherited
14-3-3 protein0.00000014860.03926Inherited
Actin depolymerizing proteins0.000010520.08405Inherited
TPR-like11Inherited
Integrin alpha N-terminal domain0.0030920Inherited
Interleukin 8-like chemokines0.00000000000042520.00109Inherited
Radical SAM enzymes11Inherited
POZ domain0.0056570.00002772Inherited
Metalloproteases ("zincins"), catalytic domain0.810Inherited
Ubiquitin-like0.69840.00007972Inherited
Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin0.00033560.524Inherited
Casein kinase II beta subunit0.01630.4165Inherited
WD40 repeat-like0.00004161Inherited
Ferritin-like0.1831Inherited
Ankyrin repeat0.39260.0000000002666Inherited
PX domain0.000051260.5982Inherited
NAP-like0.0012870.4425Inherited
ARM repeat0.0010020.0000001345Inherited
RNA-binding domain, RBD0.19020.09266Inherited
eIF4e-like0.56151Inherited
Profilin (actin-binding protein)0.010170.42Inherited
AF0104/ALDC/Ptd012-like0.054770.1543Inherited
Nucleotide-diphospho-sugar transferases11Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.54831Inherited
Terpenoid synthases11Inherited
Proton glutamate symport protein0.18721Inherited
Aquaporin-like0.0000033510.2643Inherited
Trefoil0.010360.1949Inherited
Calponin-homology domain, CH-domain0.0079590Inherited
Troponin coil-coiled subunits0.067870.0000001316Inherited
Tubulin chaperone cofactor A0.0014020.0808Inherited
P-loop containing nucleoside triphosphate hydrolases0.00017991Inherited
Defensin-like0.006161Inherited
Cu,Zn superoxide dismutase-like0.00000016160.01812Inherited
Phospholipase D/nuclease0.0000030350.9286Inherited
NAD(P)-linked oxidoreductase0.60171Inherited
Voltage-gated potassium channels0.0041810Inherited
Acid proteases0.000000000074390.9292Inherited
Cysteine proteinases0.000000000075340.3436Inherited
Acyl-CoA N-acyltransferases (Nat)11Inherited
Inhibitor of apoptosis (IAP) repeat0.0001660.009945Inherited
KRAB domain (Kruppel-associated box)11Inherited
Concanavalin A-like lectins/glucanases0.11110Inherited
Bcl-2 inhibitors of programmed cell death0.00000000016610.002056Inherited
NagB/RpiA/CoA transferase-like0.2761Inherited
C-type lectin-like0.006160.00000000002572Inherited


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Family

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Adenylyl and guanylyl cyclase catalytic domain0.00011840.0000000571Direct
Astacin0.00033330.00000002753Direct
Bee venom hyaluronidase0.00000000000032830.0000000000001794Direct
Core binding factor beta, CBF0.000000078370.000001699Direct
Ephrin ectodomain0.00047330.000000000003313Direct
Eukaryotic proteases0.000000000000056990.0000000000001807Direct
Fibroblast growth factors (FGF)00Direct
Fibronectin type III0.00024640Direct
Forkhead DNA-binding domain0.0000023290Direct
Higher-molecular-weight phosphotyrosine protein phosphatases0.00000005570Direct
HLH, helix-loop-helix DNA-binding domain00Direct
Homeodomain0.0000056390Direct
Insect pheromone/odorant-binding proteins00.00000000000002548Direct
Integrin alpha N-terminal domain0.0000023290Direct
Laminin G-like module0.00018890Direct
Long-chain cytokines0.0000014560.000007754Direct
Mitochondrial cytochrome c oxidase subunit VIIb0.0000023290.0001435Direct
Myosin S1 fragment, N-terminal domain0.00074920.0001901Direct
Ngr ectodomain-like0.00054790Direct
Nuclear receptor0.000017940Direct
Nuclease0.0000005380.0004516Direct
Paired domain00Direct
Papain-like00.00009611Direct
Plakophilin 1 helical region0.000021050.000003161Direct
Platelet-derived growth factor-like0.00078040Direct
Protein kinases, catalytic subunit00Direct
Retinol binding protein-like0.000000000018270.0006624Direct
Rhodopsin-like0.000000000023230Direct
Sema domain0.0000023290Direct
Serpins0.0000000010010.0007066Direct
Short-chain cytokines0.00000000056750.00004457Direct
Spectrin repeat0.00000025750Direct
Spermadhesin, CUB domain00Direct
SRF-like0.00011840Direct
Stathmin00.000000000000005999Direct
T-box0.00074920Direct
Tropomyosin0.00010480.0005667Direct
Mitochondrial carrier0.11951Inherited
Phosphatidylethanolamine binding protein0.000054630.5008Inherited
Tyrosine-dependent oxidoreductases11Inherited
Formate/glycerate dehydrogenases, substrate-binding domain0.00074920.7609Inherited
Extended AAA-ATPase domain0.020161Inherited
Calmodulin-like0.000000022220.1229Inherited
S100 proteins0.0000048770.03002Inherited
ML domain0.0028140.1073Inherited
Interferons/interleukin-10 (IL-10)0.59421Inherited
Metallothionein0.25731Inherited
ALDH-like0.96271Inherited
Caspase catalytic domain0.0000000025140.004023Inherited
Phoshatidylinositol transfer protein, PITP0.0000042090.01487Inherited
Armadillo repeat0.014890.00004465Inherited
MoCo biosynthesis proteins0.078261Inherited
Globins0.0077731Inherited
Preprotein translocase SecY subunit0.00000067110.003234Inherited
Annexin0.00068370.8601Inherited
14-3-3 protein0.00000074570.08876Inherited
CCP-like0.10191Inherited
Plastocyanin/azurin-like0.061181Inherited
Germin/Seed storage 7S protein0.17140.8836Inherited
Nucleosome core histones11Inherited
Cofilin-like0.000057050.01212Inherited
Tetratricopeptide repeat (TPR)11Inherited
Interleukin 8-like chemokines0.000000000036450.01166Inherited
BTB/POZ domain0.003130.00007497Inherited
Plant lipid-transfer and hydrophobic proteins0.000011850.07435Inherited
Tubulin, C-terminal domain0.00078040.00521Inherited
Casein kinase II beta subunit0.027880.5185Inherited
Small Kunitz-type inhibitors & BPTI-like toxins0.0058870.000008255Inherited
WD40-repeat0.0040271Inherited
Ankyrin repeat0.71280.00004173Inherited
PX domain0.000086460.8843Inherited
NAP-like0.0022250.6015Inherited
Canonical RBD0.22820.1897Inherited
Penta-EF-hand proteins0.002110.2726Inherited
Translation initiation factor eIF4e0.65441Inherited
Carboxylesterase0.82831Inherited
Classic zinc finger, C2H20.051040.00000008845Inherited
Profilin (actin-binding protein)0.020160.5316Inherited
AF0104-like0.0015830.02262Inherited
Ferritin0.043670.9218Inherited
C5 cytosine-specific DNA methylase, DCM0.0073150.001774Inherited
Isoprenyl diphosphate synthases0.85261Inherited
Proton glutamate symport protein0.24641Inherited
Aquaporin-like0.000025480.4915Inherited
Trefoil0.014340.2655Inherited
CAF1-like ribonuclease0.011940.1331Inherited
Calponin-homology domain, CH-domain0.0038220Inherited
Protein prenyltransferases0.0093440.6752Inherited
Troponin I0.096890.252Inherited
SelR domain0.17681Inherited
Tubulin chaperone cofactor A0.002110.1061Inherited
Arylsulfatase0.32030.009503Inherited
Thioesterases0.00031950.04652Inherited
G proteins01Inherited
AlkB-like0.086771Inherited
Defensin0.00000016110.2652Inherited
Gonadodropin/Follitropin0.010490.7626Inherited
Cu,Zn superoxide dismutase-like0.0000011240.05114Inherited
Aldo-keto reductases (NADP)0.79721Inherited
Voltage-gated potassium channels0.032380.00000000000001727Inherited
C1 set domains (antibody constant domain-like)0.22461Inherited
Pepsin-like0.00000000000022050.7122Inherited
UDPGT-like0.74941Inherited
Clathrin coat assembly domain0.00028640.4224Inherited
C-type lectin domain0.051040.1988Inherited
Inhibitor of apoptosis (IAP) repeat0.000420.03024Inherited
KRAB domain (Kruppel-associated box)11Inherited
Ribonuclease A-like0.0000000094580.00148Inherited
Galectin (animal S-lectin)0.0017020.1254Inherited
Bcl-2 inhibitors of programmed cell death0.0000000035480.01028Inherited
IF2B-like0.0000053590.022Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Protein kinase-like (PK-like)0Direct
Glucocorticoid receptor-like (DNA-binding domain)0Direct
Metalloproteases ("zincins"), catalytic domain0Direct
Homeodomain-like0Direct
HMG-box0Direct
EF-hand0Direct
Family A G protein-coupled receptor-like0Direct
(Phosphotyrosine protein) phosphatases II0Direct
Galactose-binding domain-like0Direct
Concanavalin A-like lectins/glucanases0Direct
SH3-domain0Direct
Calponin-homology domain, CH-domain0Direct
L domain-like0Direct
Voltage-gated potassium channels0Direct
SMAD/FHA domain0Direct
beta-beta-alpha zinc fingers0Direct
PDZ domain-like0Direct
PH domain-like0Direct
Integrin alpha N-terminal domain0Direct
YWTD domain0Direct
Cadherin-like0Direct
Fibronectin type III0Direct
Spectrin repeat0Direct
Immunoglobulin0Direct
HLH, helix-loop-helix DNA-binding domain0Direct
DBL homology domain (DH-domain)0Direct
Stathmin0Direct
SH2 domain0Direct
Transcription factor STAT-4 N-domain0Direct
Invertebrate chitin-binding proteins0Direct
Growth factor receptor domain0Direct
Hemopexin-like domain0Direct
Snake toxin-like0Direct
Nuclear receptor ligand-binding domain0Direct
Spermadhesin, CUB domain0Direct
SMAD MH1 domain0Direct
Cytokine0Direct
p53-like transcription factors0Direct
Sema domain0Direct
Bromodomain0Direct
Cystine-knot cytokines0Direct
EGF/Laminin0Direct
SAM/Pointed domain0Direct
SRF-like0Direct
Plexin repeat0Direct
Integrin domains0Direct
Leucine zipper domain0Direct
Olfactory marker protein0Direct
FnI-like domain0Direct
Insect pheromone/odorant-binding proteins0Direct
TSP-1 type 1 repeat0Direct
LDL receptor-like module0Direct
Frizzled cysteine-rich domain0Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
Second domain of FERM0Direct
STAT0Direct
A heparin-binding domain0Direct
Heparin-binding domain from vascular endothelial growth factor0Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
Domain from hypothetical 2610208m17rik protein0Direct
Orange domain-like0Direct
DPY module0Direct
FYVE/PHD zinc finger0.000000000000001898Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.000000000000001898Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.000000000000005554Direct
Pseudo ankyrin repeat-like0.000000000000009141Direct
Tudor/PWWP/MBT0.00000000000001092Direct
Cysteine-rich DNA binding domain, (DM domain)0.00000000000001182Direct
Notch domain0.00000000000001182Direct
Myosin rod fragments0.0000000000000127Direct
Chitinase insertion domain0.00000000000002495Direct
CalX-like0.00000000000004042Direct
Cysteine-rich domain0.00000000000005225Direct
Intermediate filament protein, coiled coil region0.0000000000000573Direct
Plakin repeat0.00000000000006404Direct
GTPase activation domain, GAP0.00000000000006824Direct
Fibrinogen C-terminal domain-like0.0000000000005426Direct
TIMP-like0.0000000000006474Direct
Kringle-like0.000000000000899Direct
GLA-domain0.000000000001027Direct
DEATH domain0.000000000001492Direct
Hedgehog/DD-peptidase0.000000000002391Direct
C-type lectin-like0.00000000001461Direct
PGBD-like0.000000000066Direct
Midkine0.0000000000672Direct
BRK domain-like0.0000000001261Direct
Ankyrin repeat0.0000000001539Direct
Hedgehog/intein (Hint) domain0.0000000003096Direct
p53 tetramerization domain0.000000002015Direct
Multidrug efflux transporter AcrB transmembrane domain0.000000003381Direct
FAS1 domain0.00000001035Direct
E set domains0.00000001202Direct
BPTI-like0.00000001205Direct
TAZ domain0.00000001263Direct
PAZ domain0.00000001865Direct
BAR/IMD domain-like0.00000003208Direct
SRCR-like0.0000000545Direct
Troponin coil-coiled subunits0.0000000819Direct
ARM repeat0.00000008372Direct
KA1-like0.00000008616Direct
A DNA-binding domain in eukaryotic transcription factors0.00000009799Direct
SET domain0.0000001031Direct
cAMP-binding domain-like0.0000001344Direct
Nuclear receptor coactivator interlocking domain0.0000001344Direct
Triple coiled coil domain of C-type lectins0.0000001415Direct
Eferin C-derminal domain-like0.0000001734Direct
NHL repeat0.0000002615Direct
Core binding factor beta, CBF0.000000352Direct
Protease propeptides/inhibitors0.0000003751Direct
DNA-binding pseudobarrel domain0.0000004589Direct
Hook domain0.0000006394Direct
HR1 repeat0.0000007023Direct
Kazal-type serine protease inhibitors0.0000007667Direct
GAS2 domain-like0.000000814Direct
4-helical cytokines0.0000008486Direct
GCM domain0.000001234Direct
Methuselah ectodomain0.000001434Direct
TAF(II)230 TBP-binding fragment0.000001434Direct
Fibrinogen coiled-coil and central regions0.000002117Direct
Formin homology 2 domain (FH2 domain)0.000002437Direct
G protein-binding domain0.00000268Direct
Cullin homology domain0.000002944Direct
Trypsin-like serine proteases0.000003153Direct
Chromo domain-like0.000004269Direct
Kix domain of CBP (creb binding protein)0.000004695Direct
IP3 receptor type 1 binding core, domain 20.000005325Direct
ARID-like0.000005491Direct
Regulator of G-protein signaling, RGS0.000006365Direct
beta-sandwich domain of Sec23/240.000006792Direct
Nitric oxide (NO) synthase oxygenase domain0.000006851Direct
Heme-dependent peroxidases0.000009311Direct
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0.000009326Direct
Nicotinic receptor ligand binding domain-like0.00001069Direct
Rap/Ran-GAP0.00001116Direct
Nucleoplasmin-like core domain0.00001328Direct
TAFH domain-like0.00001848Direct
POZ domain0.0000186Direct
Lipocalins0.00002276Direct
Insulin-like0.00002658Direct
Helical domain of Sec23/240.00003036Direct
Connexin430.0000305Direct
GDNF receptor-like0.0000305Direct
Phenylalanine zipper0.00003066Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00003347Direct
Serpins0.00003353Direct
Myosin S1 fragment, N-terminal domain0.00004231Direct
Eukaryotic DNA topoisomerase I, dispensable insert domain0.00004564Direct
Ubiquitin-like0.00005429Direct
Mitochondrial cytochrome c oxidase subunit VIIb0.00006664Direct
DNA-binding protein LAG-1 (CSL)0.0000717Direct
WW domain0.00008879Direct
PAH2 domain0.00009643Direct
Granulin repeat0.0001104Direct
Serine protease inhibitors0.0001265Direct
"Winged helix" DNA-binding domain0.0001468Direct
alpha-catenin/vinculin-like0.0001512Direct
Subtilisin-like0.000165Direct
CRAL/TRIO domain0.0001774Direct
L27 domain0.0001925Direct
Cyclin-like0.0002237Direct
Tropomyosin0.0002321Direct
Zn-finger domain of Sec23/240.0002512Direct
Ras GEF0.0002523Direct
CCHHC domain0.0002527Direct
Lipoxigenase0.0002589Direct
TATA-box binding protein-like0.0002638Direct
RNase A-like0.0002676Direct
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain0.0002814Direct
DNA-binding domain0.0002945Direct
Dimerization cofactor of HNF-1 alpha0.0003166Direct
YVTN repeat-like/Quinoprotein amine dehydrogenase0.0003217Direct
A middle domain of Talin 10.000323Direct
HIT/MYND zinc finger-like0.0003277Direct
Satiety factor CART (cocaine and amphetamine regulated transcript)0.0003617Direct
C-terminal, gelsolin-like domain of Sec23/240.0004247Direct
FAT domain of focal adhesion kinase0.0004471Direct
Assembly domain of cartilage oligomeric matrix protein0.0005338Direct
Tubulin C-terminal domain-like0.0005489Direct
Cullin repeat-like0.0006057Direct
Sec7 domain0.000671Direct
Interleukin 8-like chemokines0.0007777Direct
Polo-box domain0.0008736Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0.0009704Direct
Preprotein translocase SecY subunit0.0009932Direct
UBC-like1Inherited
MFS general substrate transporter1Inherited
NTF2-like1Inherited
Elafin-like0.4256Inherited
Annexin0.5975Inherited
Prefoldin0.04696Inherited
Nudix1Inherited
Arabinanase/levansucrase/invertase1Inherited
PHL pollen allergen0.2393Inherited
Barwin-like endoglucanases1Inherited
Aquaporin-like0.2175Inherited
Translation proteins1Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain1Inherited
14-3-3 protein0.03023Inherited
Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin0.4469Inherited
Profilin (actin-binding protein)0.3538Inherited
CheY-like1Inherited
VHP, Villin headpiece domain0.005485Inherited
Nop domain0.6935Inherited
Actin-like ATPase domain1Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01754Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.06723Inherited
Single hybrid motif1Inherited
Rudiment single hybrid motif1Inherited
Blood coagulation inhibitor (disintegrin)0.0571Inherited
PUA domain-like1Inherited
PKD domain0.7483Inherited
HSP20-like chaperones1Inherited
UBA-like1Inherited
Alkaline phosphatase-like0.3792Inherited
PLC-like phosphodiesterases0.4534Inherited
Glycoside hydrolase/deacetylase1Inherited
vWA-like0.1223Inherited
Cysteine proteinases0.2863Inherited
SPOC domain-like0.07406Inherited
CAD & PB1 domains0.0267Inherited
Creatinase/aminopeptidase1Inherited
Pseudouridine synthase1Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain1Inherited
Ribosomal proteins S24e, L23 and L15e0.7842Inherited
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)0.01369Inherited
Hypothetical protein AF0491, middle domain0.007455Inherited
FYSH domain0.1292Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.08657Inherited
S-adenosylmethionine synthetase0.3083Inherited
DNA-glycosylase1Inherited
TB module/8-cys domain0.005162Inherited
Tim10-like1Inherited
Acid proteases0.8309Inherited
Leukotriene A4 hydrolase N-terminal domain0.2817Inherited
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain0.004183Inherited
PHM/PNGase F0.1164Inherited
LysM domain0.9971Inherited
Transglutaminase, two C-terminal domains0.001499Inherited
LCCL domain0.6474Inherited
Cystatin/monellin0.9236Inherited
NAD kinase/diacylglycerol kinase-like0.6102Inherited
Mss4-like1Inherited
Tubulin nucleotide-binding domain-like0.02283Inherited
Homodimeric domain of signal transducing histidine kinase1Inherited
VPS9 domain0.7866Inherited
FAD/NAD(P)-binding domain1Inherited
Tumor suppressor gene product Apc0.05841Inherited
N-terminal coiled coil domain from apc0.05841Inherited
Suppressor of Fused, N-terminal domain0.008615Inherited
GFP-like0.002406Inherited
Thiolase-like1Inherited
C-terminal domain of PLC-beta0.9365Inherited
Smc hinge domain0.2998Inherited
Insert subdomain of RNA polymerase alpha subunit0.9509Inherited
RBP11-like subunits of RNA polymerase1Inherited
Sec1/munc18-like (SM) proteins0.5726Inherited
dsRNA-binding domain-like0.1658Inherited
Arginase/deacetylase0.02074Inherited
ALDH-like1Inherited
Thyroglobulin type-1 domain0.05351Inherited
Periplasmic binding protein-like II1Inherited
Periplasmic binding protein-like I0.01622Inherited
Retrovirus zinc finger-like domains1Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase1Inherited
Activator of Hsp90 ATPase, Aha10.08263Inherited
EB1 dimerisation domain-like0.5334Inherited
SEA domain0.009633Inherited
LEA14-like0.7242Inherited
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain0.6078Inherited
DUSP-like0.2909Inherited
Cap-Gly domain0.1281Inherited
N-terminal domain of cbl (N-cbl)0.08458Inherited
Putative DNA-binding domain0.09343Inherited
SNF-like1Inherited
RNA-binding domain, RBD0.07329Inherited
MAST3 pre-PK domain-like0.01559Inherited
Eukaryotic type KH-domain (KH-domain type I)0.001544Inherited
Colipase-like0.02364Inherited
Glutamine synthetase, N-terminal domain0.3578Inherited
DHH phosphoesterases0.9999Inherited
ArfGap/RecO-like zinc finger0.3146Inherited
Clavaminate synthase-like1Inherited
PEBP-like0.8966Inherited
Calcium-dependent phosphotriesterase1Inherited
Protein serine/threonine phosphatase 2C, C-terminal domain0.6822Inherited
alpha/beta-Hydrolases1Inherited
Succinyl-CoA synthetase domains1Inherited
Oxysterol-binding protein-like1Inherited
Nucleoside diphosphate kinase, NDK1Inherited
Rhomboid-like1Inherited
PWI domain0.05519Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
PreATP-grasp domain1Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain0.1175Inherited
Aspartate/ornithine carbamoyltransferase0.2492Inherited
Carbamoyl phosphate synthetase, large subunit connection domain0.1841Inherited
Methylglyoxal synthase-like0.5378Inherited
Class I glutamine amidotransferase-like1Inherited
Metallo-dependent hydrolases1Inherited
Composite domain of metallo-dependent hydrolases0.5126Inherited
E2F-DP heterodimerization region0.08819Inherited
Class II aaRS and biotin synthetases1Inherited
SBT domain0.04084Inherited
Pectin lyase-like1Inherited
Defensin-like0.9962Inherited
ABC transporter transmembrane region0.002749Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
SpoIIaa-like1Inherited
DNA mismatch repair protein MutL0.1429Inherited
PLP-dependent transferases1Inherited
Acetyl-CoA synthetase-like1Inherited
PR-1-like1Inherited
RCC1/BLIP-II0.002043Inherited
Hect, E3 ligase catalytic domain0.1567Inherited
Caspase-like0.01022Inherited
Metallothionein1Inherited
RUN domain-like1Inherited
Actin depolymerizing proteins0.06625Inherited
Ribosomal protein S5 domain 2-like1Inherited
ADC-like0.8914Inherited
Cdc48 domain 2-like0.1651Inherited
Activating enzymes of the ubiquitin-like proteins1Inherited
Bacterial exopeptidase dimerisation domain1Inherited
Tautomerase/MIF0.922Inherited
AbfB domain0.3264Inherited
Thymidylate synthase/dCMP hydroxymethylase0.4993Inherited
post-AAA+ oligomerization domain-like1Inherited
F1F0 ATP synthase subunit C0.8683Inherited
gamma-Crystallin-like0.5802Inherited
PurM C-terminal domain-like1Inherited
PurM N-terminal domain-like1Inherited
Tetraspanin0.02283Inherited
HAND domain of the nucleosome remodeling ATPase ISWI0.004466Inherited
Formyltransferase1Inherited
DNase I-like0.357Inherited
Doublecortin (DC)0.001855Inherited
Soluble quinoprotein glucose dehydrogenase0.1356Inherited
Putative isomerase YbhE0.5464Inherited
Retrovirus capsid dimerization domain-like1Inherited
Transducin (alpha subunit), insertion domain0.5565Inherited
Multidrug resistance efflux transporter EmrE1Inherited
PYP-like sensor domain (PAS domain)0.01314Inherited
LEM domain0.3235Inherited
AXH domain0.2257Inherited
V-type ATP synthase subunit C0.3194Inherited
SAND domain-like0.01196Inherited
ThrRS/AlaRS common domain0.84Inherited
C-terminal autoproteolytic domain of nucleoporin nup980.003958Inherited
Moesin tail domain0.0577Inherited
GroEL-intermediate domain like1Inherited
eIF4e-like1Inherited
CCCH zinc finger1Inherited
Bactericidal permeability-increasing protein, BPI0.1934Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.001162Inherited
Phospholipase A2, PLA20.03005Inherited
TSP type-3 repeat0.01375Inherited
Hormone receptor domain0.002356Inherited
Tetrahydrobiopterin biosynthesis enzymes-like1Inherited
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment0.01016Inherited
Cryptochrome/photolyase, N-terminal domain0.6671Inherited
Cryptochrome/photolyase FAD-binding domain0.8192Inherited
Nicotinate/Quinolinate PRTase C-terminal domain-like0.9128Inherited
DNA breaking-rejoining enzymes0.9746Inherited
SIS domain1Inherited
Metallo-dependent phosphatases1Inherited
RGC domain-like0.0112Inherited
Band 7/SPFH domain1Inherited
B-box zinc-binding domain0.4391Inherited
Casein kinase II beta subunit0.3507Inherited
RNI-like1Inherited
PRC-barrel domain0.6398Inherited
LigT-like0.1738Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase1Inherited
Type II DNA topoisomerase0.6246Inherited
LuxS/MPP-like metallohydrolase1Inherited
HMA, heavy metal-associated domain1Inherited
PRTase-like1Inherited
F-box domain1Inherited
WD40 repeat-like0.9309Inherited
SOCS box-like1Inherited
Ribonuclease H-like1Inherited
Synuclein0.1292Inherited
Glycerol-3-phosphate (1)-acyltransferase1Inherited
Proton glutamate symport protein0.9866Inherited
MIR domain0.005556Inherited
CRAL/TRIO N-terminal domain0.2308Inherited
Globin-like1Inherited
Aminoacid dehydrogenase-like, N-terminal domain1Inherited
DNA/RNA polymerases1Inherited
Toll/Interleukin receptor TIR domain0.3751Inherited
Radical SAM enzymes1Inherited
Mitochondrial carrier1Inherited
Zinc beta-ribbon1Inherited
Phoshotransferase/anion transport protein1Inherited
BEACH domain0.5018Inherited
Transferrin receptor-like dimerisation domain0.8953Inherited
Six-hairpin glycosidases1Inherited
N-terminal domain of adenylylcyclase associated protein, CAP0.05714Inherited
C-terminal domain of adenylylcyclase associated protein0.2048Inherited
Ferritin-like1Inherited
FKBP-like0.9654Inherited
Zn-dependent exopeptidases1Inherited
Ribonuclease PH domain 2-like1Inherited
Prion-like0.2555Inherited
Carboxypeptidase regulatory domain-like0.00487Inherited
Calpain large subunit, middle domain (domain III)0.4958Inherited
TNF-like0.02535Inherited
Hairpin loop containing domain-like0.002316Inherited
ACT-like0.8636Inherited
Cytochrome c oxidase subunit E0.1082Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain1Inherited
Riboflavin synthase domain-like1Inherited
Flavoproteins1Inherited
Peptidylarginine deiminase Pad4, middle domain0.2794Inherited
RuBisCo LSMT C-terminal, substrate-binding domain0.825Inherited
Pentein0.9972Inherited
Ran binding protein zinc finger-like0.09972Inherited
Nucleotidyltransferase1Inherited
Cytidine deaminase-like1Inherited
PsbU/PolX domain-like1Inherited
DNA polymerase beta, N-terminal domain-like1Inherited
DNA repair protein MutS, domain II0.7886Inherited
Dystroglycan, domain 20.00526Inherited
Kelch motif0.6918Inherited
Complement control module/SCR domain0.04011Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.9177Inherited
DHS-like NAD/FAD-binding domain1Inherited
RNase III domain-like0.8605Inherited
Carbonic anhydrase0.8549Inherited
MHC antigen-recognition domain1Inherited
lambda repressor-like DNA-binding domains0.06074Inherited
FF domain0.6639Inherited
Apolipoprotein A-I0.8192Inherited
Sialidases1Inherited
DPP6 N-terminal domain-like0.7978Inherited
Ypt/Rab-GAP domain of gyp1p1Inherited
UDP-Glycosyltransferase/glycogen phosphorylase1Inherited
RmlC-like cupins1Inherited
Phosphoenolpyruvate/pyruvate domain1Inherited
PK C-terminal domain-like0.4559Inherited
PK beta-barrel domain-like1Inherited
Fumarate reductase respiratory complex transmembrane subunits1Inherited
Seven-hairpin glycosidases1Inherited
CBS-domain pair1Inherited
HRDC-like1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
Calcium ATPase, transmembrane domain M0.1168Inherited
HAD-like1Inherited
Calcium ATPase, transduction domain A0.08089Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.02877Inherited
Acyl-CoA N-acyltransferases (Nat)1Inherited
YhbY-like0.9407Inherited
PA domain1Inherited
NAC domain0.007383Inherited
Bet v1-like1Inherited
Clathrin adaptor appendage domain0.0257Inherited
Subdomain of clathrin and coatomer appendage domain0.006526Inherited
SAICAR synthase-like0.6789Inherited
Plant invertase/pectin methylesterase inhibitor0.6131Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes1Inherited
AhpD-like1Inherited
MIT domain0.9375Inherited
WRKY DNA-binding domain0.9212Inherited
AF0104/ALDC/Ptd012-like0.124Inherited
BAH domain0.08054Inherited
BRCA2 helical domain0.008615Inherited
BRCA2 tower domain0.008615Inherited
NagB/RpiA/CoA transferase-like1Inherited
Trimeric LpxA-like enzymes1Inherited
Terpenoid synthases1Inherited
NAD(P)-linked oxidoreductase1Inherited
Agouti-related protein0.1231Inherited
SNARE fusion complex1Inherited
Cupredoxins1Inherited
ACP-like1Inherited
Clc chloride channel0.03537Inherited
Ammonium transporter1Inherited
Glycosyl hydrolase domain1Inherited
Trefoil0.1581Inherited
Galactose mutarotase-like1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Substrate-binding domain of HMG-CoA reductase0.04742Inherited
NAD-binding domain of HMG-CoA reductase0.04742Inherited
Nucleotide cyclase0.9382Inherited
SAP domain0.04799Inherited
I/LWEQ domain0.001869Inherited
Nucleotide-diphospho-sugar transferases1Inherited
Poly A polymerase C-terminal region-like0.7052Inherited
C-terminal domain of Ku800.2878Inherited
Tubulin chaperone cofactor A0.06362Inherited
PP2C-like1Inherited
Geminin coiled-coil domain0.1946Inherited
Delta-sleep-inducing peptide immunoreactive peptide0.8195Inherited
HCP-like1Inherited
Lysozyme-like1Inherited
(Trans)glycosidases1Inherited
DNA topoisomerase IV, alpha subunit0.2702Inherited
Chaperone J-domain1Inherited
Histone-fold1Inherited
Crisp domain-like0.1672Inherited
Staphylococcal nuclease0.8609Inherited
Subunits of heterodimeric actin filament capping protein Capz0.1294Inherited
The spindle assembly checkpoint protein mad20.2937Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase1Inherited
Lamin A/C globular tail domain0.09245Inherited
GroES-like1Inherited
SWIB/MDM2 domain0.2698Inherited
Dihydrofolate reductase-like1Inherited
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain0.2257Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like1Inherited
Thioredoxin-like1Inherited
Glutamine synthetase/guanido kinase1Inherited
Thiamin diphosphate-binding fold (THDP-binding)1Inherited
Small-conductance potassium channel0.3065Inherited
Cytochrome P4501Inherited
Nucleic acid-binding proteins1Inherited
DNA ligase/mRNA capping enzyme, catalytic domain1Inherited
Galactose oxidase, central domain1Inherited
ATP-dependent DNA ligase DNA-binding domain0.7628Inherited
RING/U-box1Inherited
Bcl-2 inhibitors of programmed cell death0.001483Inherited
NAP-like0.3738Inherited
DNA repair protein MutS, domain III0.8163Inherited
PABC (PABP) domain0.004793Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain1Inherited
F1 ATPase inhibitor, IF1, C-terminal domain0.002412Inherited
Chelatase0.9725Inherited
Ribosomal protein S3 C-terminal domain0.7775Inherited
DNA repair protein MutS, domain I0.7886Inherited
SNARE-like1Inherited
HSP40/DnaJ peptide-binding domain0.988Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
Transducin (heterotrimeric G protein), gamma chain0.1979Inherited
TGS-like1Inherited
Inhibitor of apoptosis (IAP) repeat0.007382Inherited
VHL0.001785Inherited
beta-N-acetylhexosaminidase-like domain0.5335Inherited
TNF receptor-like0.008015Inherited
Mib/herc2 domain-like0.1946Inherited
TPR-like1Inherited
Cu,Zn superoxide dismutase-like0.01368Inherited
GroEL apical domain-like1Inherited
GroEL equatorial domain-like1Inherited
P-domain of calnexin/calreticulin0.6514Inherited
FAD-linked reductases, C-terminal domain1Inherited
Nucleotidylyl transferase1Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases1Inherited
Quinoprotein alcohol dehydrogenase-like0.7964Inherited
Tubby C-terminal domain-like0.6473Inherited
GAF domain-like0.8483Inherited
HD-domain/PDEase-like0.9525Inherited
ValRS/IleRS/LeuRS editing domain0.9755Inherited
Somatomedin B domain0.4511Inherited
Sec63 N-terminal domain-like0.6612Inherited
Alpha-macroglobulin receptor domain0.002411Inherited
Mannose 6-phosphate receptor domain1Inherited
Anthrax protective antigen0.6582Inherited
Ricin B-like lectins0.9796Inherited
Outer arm dynein light chain 10.8922Inherited
Integrin beta tail domain0.006168Inherited
Plus3-like0.0261Inherited
BRCT domain0.7844Inherited
PX domain0.5144Inherited
TRAF domain-like1Inherited
LeuD/IlvD-like1Inherited
Aconitase iron-sulfur domain1Inherited
Phospholipase D/nuclease0.8303Inherited
Mannose-binding lectins0.9755Inherited
Acyl-CoA dehydrogenase NM domain-like1Inherited
Acyl-CoA dehydrogenase C-terminal domain-like1Inherited
KRAB domain (Kruppel-associated box)1Inherited
Class II aaRS ABD-related1Inherited
Chicken cartilage matrix protein0.02176Inherited

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