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Biological Process (BP): regulation of actin cytoskeleton organization

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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   biological_process [GO:0008150] <24>
+ + + + 4:   biological regulation [GO:0065007] <5>(165|190) (757|933|542)
+ + + 3:   regulation of biological process [GO:0050789] <34>(155|176) (709|883|505)
+ + + 3:   regulation of cellular component organization [GO:0051128] <52>(35|32) (311|310|174)
+ + 2:   regulation of cellular process [GO:0050794] <58>(138|154) (661|802|451)
+ + 2:   regulation of organelle organization [GO:0033043] <27>(20|20) (194|151|67)
+ 1:   regulation of actin filament-based process [GO:0032970] <3>(5|6) (71|50|28)
+ 1:   regulation of cytoskeleton organization [GO:0051493] <6>(8|9) (93|71|36)
0:   regulation of actin cytoskeleton organization [GO:0032956] <7>(5|6) (61|47|26)
- 1:   regulation of actin filament bundle assembly [GO:0032231] <4>(0|0) (21|16|9)
- 1:   regulation of actomyosin structure organization [GO:0110020] <4>(0|0) (16|10|3)
- 1:   regulation of myosin II filament organization [GO:0043519] <4>(0|0) (5|1|0)
- 1:   regulation of actin cytoskeleton reorganization [GO:2000249] <2>(0|0) (10|6|3)
- 1:   regulation of actin filament length [GO:0030832] <1>(5|6) (38|29|18)
- 1:   regulation of actin cytoskeleton organization by cell-cell adhesion [GO:0090138](0|0) (2|2|1)
- 1:   regulation of actin phosphorylation [GO:0043538](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Actin depolymerizing proteins00Direct
Arp2/3 complex 21 kDa subunit ARPC30.000000000094260.000000004505Direct
Arp2/3 complex subunits0.00000000015840Direct
Profilin (actin-binding protein)00Direct
Subunits of heterodimeric actin filament capping protein Capz00Direct


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Family

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Arp2/3 complex 21 kDa subunit ARPC30.00000000024650.000000009062Direct
Arp2/3 complex subunits0.00000000033920Direct
Capz alpha-1 subunit0.00000000063640.0000000005899Direct
Capz beta-1 subunit00.00000000000007569Direct
Cofilin-like00Direct
Profilin (actin-binding protein)00Direct


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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
VHP, Villin headpiece domain0Direct
BAR/IMD domain-like0Direct
SH3-domain0Direct
SAM/Pointed domain0Direct
Subunits of heterodimeric actin filament capping protein Capz0Direct
SH2 domain0Direct
Profilin (actin-binding protein)0Direct
HR1 repeat0Direct
Actin depolymerizing proteins0Direct
Arp2/3 complex subunits0Direct
PH domain-like9.676e-16Direct
C-terminal, gelsolin-like domain of Sec23/240.0000000000003645Direct
Moesin tail domain0.0000000001775Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0.0000000008539Direct
Arp2/3 complex 21 kDa subunit ARPC30.000000002695Direct
Lipoxigenase0.00000001331Direct
Arp2/3 complex 16 kDa subunit ARPC50.00000002224Direct
DBL homology domain (DH-domain)0.0000001038Direct
Thyroglobulin type-1 domain0.000001103Direct
Formin homology 2 domain (FH2 domain)0.000003445Direct
FF domain0.000005564Direct
AraD/HMP-PK domain-like0.00003089Direct
Actin-crosslinking proteins0.00005135Direct
Galactose-binding domain-like0.00006955Direct
Fibronectin type III0.0002018Direct
PDZ domain-like0.0002772Direct
Interleukin 8-like chemokines0.0003287Direct
Cystatin/monellin0.0004129Direct
Integrin beta tail domain0.0006253Direct
CRAL/TRIO domain0.0008526Direct
Ankyrin repeat0.8392Inherited
Immunoglobulin0.007387Inherited
Protein kinase-like (PK-like)0.08946Inherited
cAMP-binding domain-like0.1825Inherited
Ubiquitin-like0.2103Inherited
Nudix0.08851Inherited
ARM repeat0.8157Inherited
DNase I-like0.002894Inherited
Ras GEF0.001058Inherited
Growth factor receptor domain0.007489Inherited
G protein-binding domain0.06481Inherited
ArfGap/RecO-like zinc finger0.01964Inherited
Family A G protein-coupled receptor-like0.2406Inherited
Second domain of FERM0.004514Inherited
Actin-like ATPase domain0.948Inherited
Cysteine-rich domain0.003931Inherited
Calponin-homology domain, CH-domain1Inherited
Regulator of G-protein signaling, RGS0.6448Inherited
GTPase activation domain, GAP0.04972Inherited
Frizzled cysteine-rich domain0.1154Inherited
RNI-like0.04592Inherited
FAT domain of focal adhesion kinase0.1825Inherited
NHL repeat0.005043Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.02906Inherited
TSP-1 type 1 repeat0.03293Inherited
Plexin repeat0.1255Inherited
Sema domain0.2333Inherited
HAD-like0.823Inherited
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain0.04606Inherited
Sec7 domain0.04606Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.002331Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48097,57889
  • 48097 - Regulator of G-protein signaling, RGS
  • 57889 - Cysteine-rich domain
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    103652,50729
  • 103652 - G protein-binding domain
  • 50729 - PH domain-like
  • 0Direct
    49265,48371
  • 49265 - Fibronectin type III
  • 48371 - ARM repeat
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    55753,82754
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    82754,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 0Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0Direct
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.000000000000006464Direct
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0.0000000000006226Direct
    50156,103657
  • 50156 - PDZ domain-like
  • 103657 - BAR/IMD domain-like
  • 0.000000000001307Direct
    55550,50729
  • 55550 - SH2 domain
  • 50729 - PH domain-like
  • 0.000000000002994Direct
    69645,69645
  • 69645 - Arp2/3 complex subunits
  • 69645 - Arp2/3 complex subunits
  • 0.00000000002119Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.00000000003236Direct
    82754,82754
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.0000000001108Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.000000005638Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.00000000939Direct
    55753,47050
  • 55753 - Actin depolymerizing proteins
  • 47050 - VHP, Villin headpiece domain
  • 0.00000001993Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.00000002706Direct
    57889,50729
  • 57889 - Cysteine-rich domain
  • 50729 - PH domain-like
  • 0.0000001308Direct
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.0000001874Direct
    46785,51206
  • 46785 - "Winged helix" DNA-binding domain
  • 51206 - cAMP-binding domain-like
  • 0.0000002059Direct
    103575,82895
  • 103575 - Plexin repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000003568Direct
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.0000003573Direct
    50729,50044
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.0000005337Direct
    50729,46785
  • 50729 - PH domain-like
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0000005749Direct
    50405,50405
  • 50405 - Actin-crosslinking proteins
  • 50405 - Actin-crosslinking proteins
  • 0.00000328Direct
    48371,101447
  • 48371 - ARM repeat
  • 101447 - Formin homology 2 domain (FH2 domain)
  • 0.000008595Direct
    54236,48366
  • 54236 - Ubiquitin-like
  • 48366 - Ras GEF
  • 0.00002959Direct
    50729,57863
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 0.0002345Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.0007049Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0007049Direct
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0.0007467Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.005186Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.06481Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.01021Inherited
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0.06481Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.01021Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.948Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.1825Inherited
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.02313Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.3115Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.01683Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    103652,50729,57889
  • 103652 - G protein-binding domain
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    82754,55753,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0Direct
    55753,55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0Direct
    50044,55550,50729
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50729 - PH domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000000000000387Direct
    55550,50044,55550
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0000000000002684Direct
    55753,82754,55753
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 0.000000000003956Direct
    55753,55753,82754
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.00000000007225Direct
    55753,82754,82754
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.0000000001108Direct
    82754,82754,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 0.0000000001108Direct
    55550,50044,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.0000000001108Direct
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.000000001288Direct
    55753,55753,47050
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 47050 - VHP, Villin headpiece domain
  • 0.00000001993Direct
    48065,50729,50044
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.000000144Direct
    101912,103575,82895
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000003568Direct
    103575,82895,82895
  • 103575 - Plexin repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000003568Direct
    50044,50044,55550
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0000008765Direct
    50405,50405,50405
  • 50405 - Actin-crosslinking proteins
  • 50405 - Actin-crosslinking proteins
  • 50405 - Actin-crosslinking proteins
  • 0.00000328Direct
    47769,47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.000003738Direct
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.00009202Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.03994Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.01532Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1154Inherited
    47031,50729,56112
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.1825Inherited
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.01019Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
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