SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Biological Process (BP): regulation of GTPase activity

(show info)

Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   biological_process [GO:0008150] <24>
+ + + + 4:   biological regulation [GO:0065007] <5>(165|190) (757|933|542)
+ + + 3:   regulation of molecular function [GO:0065009] <12>(42|40) (274|255|136)
+ + 2:   regulation of catalytic activity [GO:0050790] <11>(31|29) (223|194|106)
+ 1:   regulation of hydrolase activity [GO:0051336] <24>(18|18) (150|113|52)
0:   regulation of GTPase activity [GO:0043087] <4>(3|1) (45|44|21)
- 1:   regulation of guanyl-nucleotide exchange factor activity [GO:1905097] <3>(0|0) (6|2|0)
- 1:   positive regulation of GTPase activity [GO:0043547] <2>(3|1) (30|28|12)
- 1:   heterotrimeric G-protein complex cycle [GO:0031684](0|0) (0|0|0)
- 1:   negative regulation of GTPase activity [GO:0034260](0|0) (9|3|1)


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
C2 domain (Calcium/lipid-binding domain, CaLB)0.000000000000061980.000003048Direct
Phosphoglycerate mutase-like0.0000000088130.0008696Direct
Regulator of G-protein signaling, RGS00.00000000000005545Direct


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Regulator of G-protein signaling, RGS00.000000000000007466Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this GO term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
ARM repeat0Direct
PH domain-like0Direct
Ras GEF0Direct
GTPase activation domain, GAP0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
DBL homology domain (DH-domain)0Direct
Rap/Ran-GAP0Direct
Regulator of G-protein signaling, RGS0.00000000000002928Direct
SH3-domain0.000000000008226Direct
Sema domain0.00000000001513Direct
Plexin repeat0.00000000002719Direct
BAR/IMD domain-like0.00000000005842Direct
cAMP-binding domain-like0.0000000001284Direct
Transducin (heterotrimeric G protein), gamma chain0.000000001437Direct
SAM/Pointed domain0.000000001893Direct
RCC1/BLIP-II0.000000002979Direct
Sec7 domain0.000000006058Direct
VPS9 domain0.000000006258Direct
Galactose-binding domain-like0.00000001237Direct
ArfGap/RecO-like zinc finger0.0000000267Direct
Zn-finger domain of Sec23/240.00000005843Direct
Helical domain of Sec23/240.0000001095Direct
Ubiquitin-like0.0000001349Direct
Stathmin0.0000002903Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.000001979Direct
C-terminal, gelsolin-like domain of Sec23/240.000003108Direct
Fic-like0.000005106Direct
RUN domain-like0.000006189Direct
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.0000118Direct
SEA domain0.00002263Direct
FF domain0.00007334Direct
L domain-like0.0001092Direct
BRCT domain0.0001254Direct
Phosphoglycerate mutase-like0.0006171Direct
Calponin-homology domain, CH-domain0.0007304Direct
Interleukin 8-like chemokines0.0007655Direct
NAD kinase/diacylglycerol kinase-like0.0009143Direct
Protein kinase-like (PK-like)0.6349Inherited
Fibronectin type III0.001318Inherited
Growth factor receptor domain0.03825Inherited
PDZ domain-like0.001665Inherited
beta-sandwich domain of Sec23/240.001931Inherited
PX domain0.0118Inherited
E set domains0.01458Inherited
Supernatant protein factor (SPF), C-terminal domain0.02036Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    54236,48366
  • 54236 - Ubiquitin-like
  • 48366 - Ras GEF
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50729,82185
  • 50729 - PH domain-like
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0Direct
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    50985,48065
  • 50985 - RCC1/BLIP-II
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    50044,48065
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.000000000000003737Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.000000000000003737Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.00000000000009888Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.0000000000009083Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0.000000000001709Direct
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.0000000000063Direct
    48670,48097
  • 48670 - Transducin (heterotrimeric G protein), gamma chain
  • 48097 - Regulator of G-protein signaling, RGS
  • 0.000000000007892Direct
    47473,57889
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0.00000000007561Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0.0000000001565Direct
    50729,48350
  • 50729 - PH domain-like
  • 48350 - GTPase activation domain, GAP
  • 0.0000000005162Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.0000000006683Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0.00000000448Direct
    48371,111347
  • 48371 - ARM repeat
  • 111347 - Rap/Ran-GAP
  • 0.00000000979Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0.00000002555Direct
    48350,50044
  • 48350 - GTPase activation domain, GAP
  • 50044 - SH3-domain
  • 0.0000000483Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0.00000005843Direct
    48350,54236
  • 48350 - GTPase activation domain, GAP
  • 54236 - Ubiquitin-like
  • 0.00000006137Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.0000001095Direct
    50729,49562
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.0000001136Direct
    47923,52821
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 52821 - Rhodanese/Cell cycle control phosphatase
  • 0.0000001176Direct
    46785,51206
  • 46785 - "Winged helix" DNA-binding domain
  • 51206 - cAMP-binding domain-like
  • 0.0000001176Direct
    82185,82185
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0.0000001806Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0000007169Direct
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.000001238Direct
    57196,100895
  • 57196 - EGF/Laminin
  • 100895 - Kazal-type serine protease inhibitors
  • 0.000001414Direct
    103657,50729
  • 103657 - BAR/IMD domain-like
  • 50729 - PH domain-like
  • 0.00000372Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.000007685Direct
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.0000449Direct
    55550,50729
  • 55550 - SH2 domain
  • 50729 - PH domain-like
  • 0.00007334Direct
    50729,50044
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.0001162Direct
    50729,57863
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 0.0001377Direct
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0.0001458Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.0007655Direct
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.04319Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.007386Inherited
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.1937Inherited
    100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.3634Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48065,50729,82185
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0Direct
    48065,50729,50044
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0Direct
    50729,82185,82185
  • 50729 - PH domain-like
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0Direct
    50985,48065,50729
  • 50985 - RCC1/BLIP-II
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50044,48065,50729
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.000000000000001898Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.00000000000009888Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0.000000000001709Direct
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.000000000004931Direct
    55550,50044,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.00000000004755Direct
    82919,53300,81995
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0.0000000006412Direct
    57196,57196,100895
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 100895 - Kazal-type serine protease inhibitors
  • 0.000000002122Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.00000000448Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0.00000000448Direct
    50729,49562,48350
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.00000001106Direct
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.00000003592Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.00000008315Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0000005028Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00001145Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0000449Direct
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.1937Inherited
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.3634Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
    Plot tree as:   Download Newick format tree:   Browsing in Tree_gateway:
    (show help)