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Biological Process (BP): positive regulation of molecular function

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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + 3:   biological_process [GO:0008150] <24>
+ + 2:   biological regulation [GO:0065007] <5>(165|190) (757|933|542)
+ 1:   regulation of molecular function [GO:0065009] <12>(42|40) (274|255|136)
0:   positive regulation of molecular function [GO:0044093] <11>(21|22) (167|154|83)
- 1:   positive regulation of receptor activity [GO:2000273] <21>(0|0) (3|1|0)
- 1:   positive regulation of binding [GO:0051099] <11>(1|1) (28|16|3)
- 1:   positive regulation of catalytic activity [GO:0043085] <9>(17|16) (139|121|70)
- 1:   positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091] <5>(3|3) (35|28|10)
- 1:   positive regulation of transporter activity [GO:0032411] <4>(3|3) (15|6|2)
- 1:   positive regulation of molecular function in other organism [GO:0044491] <2>(0|0) (0|0|0)
- 1:   positive regulation of electron carrier activity [GO:1904734] <1>(0|0) (0|0|0)
- 1:   positive regulation of RNA binding transcription factor activity [GO:1905257](0|0) (0|0|0)
- 1:   positive regulation of chemorepellent activity [GO:1903669](0|0) (0|0|0)
- 1:   positive regulation of ligand-dependent nuclear receptor transcription coactivator activity [GO:2000327](0|0) (3|1|0)
- 1:   positive regulation of molecular function, epigenetic [GO:0045858](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
4-helical cytokines0.0000000000022010Direct
Calcium-dependent phosphotriesterase0.00000000084130.00007198Direct
CSL zinc finger0.00001290.000001253Direct
Cu,Zn superoxide dismutase-like0.000000000000010610.000000001084Direct
Metallothionein0.000001180.00009972Direct
RNase A-like00.0000000000003647Direct
Phosphoglycerate mutase-like0.000098360.1049Inherited
Family A G protein-coupled receptor-like0.34830.0000000000053Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0038210.4339Inherited
Cytokine0.0000000030640.002129Inherited
Protein kinase-like (PK-like)0.081480.000000009495Inherited
Regulator of G-protein signaling, RGS0.011190.01336Inherited
Thioredoxin-like0.00012830.6772Inherited
Activating enzymes of the ubiquitin-like proteins0.11420.2164Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.000000037760.05428Inherited
L30e-like0.072790.1773Inherited
Insulin-like0.000024440.001831Inherited
Class I glutamine amidotransferase-like0.0055460.5414Inherited
EF-hand0.00015260.1047Inherited
P-loop containing nucleoside triphosphate hydrolases0.12041Inherited
Bcl-2 inhibitors of programmed cell death0.030930.2201Inherited


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Family

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
CSL zinc finger0.000017770.000002607Direct
Cu,Zn superoxide dismutase-like0.000000000000053090.000000006503Direct
Fibroblast growth factors (FGF)0.0000000060640.0009011Direct
Interferons/interleukin-10 (IL-10)00.000000000004049Direct
Long-chain cytokines0.000000014990.0000000000004287Direct
Metallothionein0.0000031010.0002593Direct
Ribonuclease A-like00.000000000003154Direct
S100 proteins0.000000000071320.00000006282Direct
SGL-like0.00000000005070.00000002142Direct
G proteins0.000860.2184Inherited
Rhodopsin-like0.17630.000000004942Inherited
Proteasome subunits0.0017110.1139Inherited
Protein kinases, catalytic subunit0.075810.000000004856Inherited
Regulator of G-protein signaling, RGS0.009970.01443Inherited
Thioltransferase0.000020430.003154Inherited
Cystathionine synthase-like0.065980.6156Inherited
Ubiquitin activating enzymes (UBA)0.0038870.01274Inherited
Insulin-like0.000042140.001804Inherited
DJ-1/PfpI0.00011530.006377Inherited
Calmodulin-like0.0075350.1971Inherited
Bcl-2 inhibitors of programmed cell death0.028480.2245Inherited
Papain-like0.0036850.003175Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this GO term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Cystine-knot cytokines0Direct
Heparin-binding domain from vascular endothelial growth factor0Direct
Transcription factor STAT-4 N-domain0Direct
4-helical cytokines0Direct
STAT0Direct
RNase A-like0.0000000000001964Direct
TNF-like0.0000000000003598Direct
Chitinase insertion domain0.0000000000006366Direct
Family A G protein-coupled receptor-like0.000000000002953Direct
Hormone receptor domain0.000000000003871Direct
Satiety factor CART (cocaine and amphetamine regulated transcript)0.0000000006128Direct
Cu,Zn superoxide dismutase-like0.0000000006369Direct
Protein kinase-like (PK-like)0.000000005742Direct
Concanavalin A-like lectins/glucanases0.000000006863Direct
Hedgehog/DD-peptidase0.00000008006Direct
GTPase activation domain, GAP0.0000001232Direct
B-box zinc-binding domain0.0000001855Direct
DEATH domain0.0000002636Direct
EGF/Laminin0.0000004705Direct
CSL zinc finger0.0000008041Direct
Hedgehog/intein (Hint) domain0.000000878Direct
Smac/diablo0.000003882Direct
RGC domain-like0.000003942Direct
Cysteine-rich domain0.000004903Direct
DNA clamp0.000008654Direct
GLA-domain0.00001275Direct
post-AAA+ oligomerization domain-like0.00001275Direct
Oncogene products0.00002262Direct
p53-like transcription factors0.00002327Direct
Ras GEF0.00004201Direct
Calcium-dependent phosphotriesterase0.00004896Direct
TAZ domain0.00006133Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0.00006133Direct
Metallothionein0.00006814Direct
Nuclear receptor coactivator interlocking domain0.00009199Direct
Polo-box domain0.0001394Direct
PTPA-like0.0001538Direct
Kix domain of CBP (creb binding protein)0.000195Direct
Colipase-like0.0003405Direct
VPS9 domain0.000367Direct
Proteasome activator0.0004576Direct
Zn-finger domain of Sec23/240.0008572Direct
Immunoglobulin0.0009782Direct
Galactose-binding domain-like0.3437Inherited
Growth factor receptor domain0.2131Inherited
Cyclin-like1Inherited
cAMP-binding domain-like0.9036Inherited
DNase I-like1Inherited
GAT-like domain0.0238Inherited
ENTH/VHS domain0.3648Inherited
(Phosphotyrosine protein) phosphatases II1Inherited
POZ domain1Inherited
Phosphoglycerate mutase-like0.08328Inherited
"Winged helix" DNA-binding domain0.142Inherited
RNA-binding domain, RBD0.866Inherited
Eukaryotic type KH-domain (KH-domain type I)0.7458Inherited
vWA-like0.009156Inherited
SH3-domain0.4191Inherited
Pectin lyase-like1Inherited
Complement control module/SCR domain0.8995Inherited
TNF receptor-like0.1582Inherited
Rap/Ran-GAP0.1276Inherited
FAT domain of focal adhesion kinase0.8284Inherited
Interleukin 8-like chemokines0.09809Inherited
Leucine zipper domain0.9607Inherited
ARM repeat0.1454Inherited
Periplasmic binding protein-like I1Inherited
IP3 receptor type 1 binding core, domain 20.00522Inherited
Nuclear receptor ligand-binding domain0.08872Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.6416Inherited
MIR domain0.06809Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3662Inherited
WD40 repeat-like0.9419Inherited
TPR-like1Inherited
UBC-like0.2752Inherited
NAD(P)-linked oxidoreductase1Inherited
Sialidases0.006704Inherited
WW domain0.5118Inherited
YWTD domain0.01784Inherited
Second domain of FERM0.7328Inherited
Cytidine deaminase-like0.1911Inherited
Thioredoxin-like0.5876Inherited
SAND domain-like0.1117Inherited
DHS-like NAD/FAD-binding domain0.251Inherited
Bromodomain0.5047Inherited
lambda repressor-like DNA-binding domains0.5507Inherited
Orange domain-like0.8616Inherited
DNA repair protein MutS, domain III0.08164Inherited
Nucleic acid-binding proteins1Inherited
Calpain large subunit, middle domain (domain III)0.04764Inherited
Activating enzymes of the ubiquitin-like proteins0.1763Inherited
Trimerization domain of TRAF0.4433Inherited
Cysteine proteinases0.9912Inherited
Ran binding protein zinc finger-like0.07902Inherited
JAB1/MPN domain0.008793Inherited
ARID-like0.1633Inherited
L domain-like0.001388Inherited
CRAL/TRIO domain0.008063Inherited
PH domain-like0.1219Inherited
FF domain0.01638Inherited
SEA domain0.01658Inherited
C-terminal, gelsolin-like domain of Sec23/240.0206Inherited
ArfGap/RecO-like zinc finger0.07902Inherited
BAR/IMD domain-like0.1308Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.5033Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.04219Inherited
beta-sandwich domain of Sec23/240.04385Inherited
BRCT domain0.04471Inherited
PX domain0.5076Inherited
Putative DNA-binding domain0.697Inherited
Tetraspanin0.04199Inherited
Helical domain of Sec23/240.001458Inherited
Regulator of G-protein signaling, RGS0.009997Inherited
Integrin alpha N-terminal domain0.01784Inherited
FAD/NAD(P)-binding domain1Inherited
FAD-linked reductases, C-terminal domain1Inherited
Chaperone J-domain0.874Inherited
Cytokine0.001537Inherited
Troponin coil-coiled subunits0.1105Inherited
Tropomyosin0.882Inherited
SAM/Pointed domain0.003433Inherited
PDZ domain-like0.5094Inherited
Class I glutamine amidotransferase-like0.4626Inherited
Ankyrin repeat1Inherited
Insulin-like0.001317Inherited
Spectrin repeat0.3464Inherited
ABC transporter transmembrane region1Inherited
EF-hand0.08311Inherited
Calponin-homology domain, CH-domain0.9921Inherited
TB module/8-cys domain0.01554Inherited
CAD & PB1 domains0.03597Inherited
Hook domain0.04079Inherited
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0.9511Inherited
(Trans)glycosidases1Inherited
SRF-like0.3017Inherited
DBL homology domain (DH-domain)0.4489Inherited
Plexin repeat0.2911Inherited
Sema domain0.2993Inherited
E set domains1Inherited
Fibronectin type III0.7706Inherited
RNI-like0.9768Inherited
Caspase-like0.555Inherited
Bcl-2 inhibitors of programmed cell death0.1795Inherited
HLH, helix-loop-helix DNA-binding domain0.006416Inherited
PP2C-like0.394Inherited
Succinyl-CoA synthetase domains0.08133Inherited
SH2 domain0.2028Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.1818Inherited
Integrin domains0.07079Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
dsRNA-binding domain-like0.8338Inherited
Toll/Interleukin receptor TIR domain0.008642Inherited
TRAF domain-like0.08247Inherited
Frizzled cysteine-rich domain0.1582Inherited
Nucleotide cyclase0.04123Inherited
Trypsin-like serine proteases1Inherited
N-terminal domain of adenylylcyclase associated protein, CAP0.2312Inherited
C-terminal domain of adenylylcyclase associated protein0.323Inherited
Fibrinogen C-terminal domain-like1Inherited
PapD-like0.04544Inherited
Quinoprotein alcohol dehydrogenase-like0.2414Inherited
RING/U-box0.05269Inherited
Homeodomain-like1Inherited
Rhodanese/Cell cycle control phosphatase1Inherited
Roadblock/LC7 domain0.07169Inherited
Ubiquitin-like0.179Inherited
L30e-like0.1432Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    50729,82185
  • 50729 - PH domain-like
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    57501,57593
  • 57501 - Cystine-knot cytokines
  • 57593 - Heparin-binding domain from vascular endothelial growth factor
  • 0Direct
    50985,48065
  • 50985 - RCC1/BLIP-II
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    51045,50156
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0.000000000000001898Direct
    48371,48350
  • 48371 - ARM repeat
  • 48350 - GTPase activation domain, GAP
  • 0.00000000000001004Direct
    54236,48366
  • 54236 - Ubiquitin-like
  • 48366 - Ras GEF
  • 0.00000000000001886Direct
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0.0000000000006366Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0000000000007824Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0.000000000006215Direct
    52540,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.00000000002131Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.00000000002545Direct
    48726,57196
  • 48726 - Immunoglobulin
  • 57196 - EGF/Laminin
  • 0.00000000002845Direct
    54277,57889
  • 54277 - CAD & PB1 domains
  • 57889 - Cysteine-rich domain
  • 0.0000000000725Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.0000000006369Direct
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.000000001119Direct
    57630,57184
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 0.000000001592Direct
    50044,56112
  • 50044 - SH3-domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000001738Direct
    50044,48065
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.00000003482Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.00000003482Direct
    55979,55979
  • 55979 - DNA clamp
  • 55979 - DNA clamp
  • 0.0000000859Direct
    56112,54236
  • 56112 - Protein kinase-like (PK-like)
  • 54236 - Ubiquitin-like
  • 0.0000001233Direct
    50939,50939
  • 50939 - Sialidases
  • 50939 - Sialidases
  • 0.0000003948Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.000001228Direct
    49265,48403
  • 49265 - Fibronectin type III
  • 48403 - Ankyrin repeat
  • 0.000002058Direct
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000002122Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.000002912Direct
    56112,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 0.000003748Direct
    48371,111347
  • 48371 - ARM repeat
  • 111347 - Rap/Ran-GAP
  • 0.000003772Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0.00001005Direct
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0.00001057Direct
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.00001254Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0.00001447Direct
    48350,54236
  • 48350 - GTPase activation domain, GAP
  • 54236 - Ubiquitin-like
  • 0.00002262Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00003657Direct
    50729,48350
  • 50729 - PH domain-like
  • 48350 - GTPase activation domain, GAP
  • 0.00004213Direct
    46785,51206
  • 46785 - "Winged helix" DNA-binding domain
  • 51206 - cAMP-binding domain-like
  • 0.00004252Direct
    46565,144217
  • 46565 - Chaperone J-domain
  • 144217 - CSL zinc finger
  • 0.00004252Direct
    48350,50044
  • 48350 - GTPase activation domain, GAP
  • 50044 - SH3-domain
  • 0.00006883Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0.0000906Direct
    50729,49562
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.0001538Direct
    50156,52540
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000195Direct
    54495,57850
  • 54495 - UBC-like
  • 57850 - RING/U-box
  • 0.0002462Direct
    46565,52833
  • 46565 - Chaperone J-domain
  • 52833 - Thioredoxin-like
  • 0.0002462Direct
    57190,57190
  • 57190 - Colipase-like
  • 57190 - Colipase-like
  • 0.0002462Direct
    160481,52540
  • 160481 - BRK domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0002462Direct
    57196,100895
  • 57196 - EGF/Laminin
  • 100895 - Kazal-type serine protease inhibitors
  • 0.0004576Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0005009Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.0008365Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0.0008572Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.4422Inherited
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.09809Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.00344Inherited
    52058,56219
  • 52058 - L domain-like
  • 56219 - DNase I-like
  • 0.002969Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 1Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.01181Inherited
    54791,54791
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 0.07329Inherited
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.3073Inherited
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 1Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 1Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1866Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.09423Inherited
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.003908Inherited
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.001997Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00745Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 1Inherited
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0.2025Inherited
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.02526Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.02526Inherited
    56112,50729
  • 56112 - Protein kinase-like (PK-like)
  • 50729 - PH domain-like
  • 0.004581Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.4381Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.9433Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.7892Inherited
    46955,63763
  • 46955 - Putative DNA-binding domain
  • 63763 - SAND domain-like
  • 0.1154Inherited
    63825,57184
  • 63825 - YWTD domain
  • 57184 - Growth factor receptor domain
  • 0.07716Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.07902Inherited
    47095,47095
  • 47095 - HMG-box
  • 47095 - HMG-box
  • 0.3184Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.8616Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 1Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07825Inherited
    57889,49562
  • 57889 - Cysteine-rich domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.04918Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.04918Inherited
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0.07914Inherited
    57953,49599
  • 57953 - Trimerization domain of TRAF
  • 49599 - TRAF domain-like
  • 0.4433Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.07005Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.0899Inherited
    57850,57933
  • 57850 - RING/U-box
  • 57933 - TAZ domain
  • 0.001786Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.1633Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.2312Inherited
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0.323Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.9956Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.251Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.251Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.9742Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.008063Inherited
    55550,50729
  • 55550 - SH2 domain
  • 50729 - PH domain-like
  • 0.01638Inherited
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0.04918Inherited
    103657,50729
  • 103657 - BAR/IMD domain-like
  • 50729 - PH domain-like
  • 0.07716Inherited
    50729,57863
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 0.1894Inherited
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.01996Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.2878Inherited
    100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 1Inherited
    48403,50044
  • 48403 - Ankyrin repeat
  • 50044 - SH3-domain
  • 0.001176Inherited
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.001458Inherited
    82185,82185
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0.07716Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.001362Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.07902Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.1141Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.00134Inherited
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 1Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.3896Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01848Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 1Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.09076Inherited
    48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.6112Inherited
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0.671Inherited
    46966,47473
  • 46966 - Spectrin repeat
  • 47473 - EF-hand
  • 0.2329Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.2386Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.09809Inherited
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.003524Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.006809Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.006809Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.01374Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.07079Inherited
    49562,54236
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 54236 - Ubiquitin-like
  • 0.1894Inherited
    57581,57581
  • 57581 - TB module/8-cys domain
  • 57581 - TB module/8-cys domain
  • 0.001016Inherited
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.002536Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 1Inherited
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0.5401Inherited
    52821,52799
  • 52821 - Rhodanese/Cell cycle control phosphatase
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 1Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.2312Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.4402Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.3607Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.8908Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0688Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01991Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.5526Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8004Inherited
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0.01554Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.7733Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.1777Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.9521Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.2475Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.008646Inherited
    49599,49599
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0.005171Inherited
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.8284Inherited
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0.7493Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.874Inherited
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.8373Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.3073Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57630,57196,57184
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    48065,50729,82185
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0Direct
    50729,82185,82185
  • 50729 - PH domain-like
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    50985,48065,50729
  • 50985 - RCC1/BLIP-II
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    51045,51045,50156
  • 51045 - WW domain
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0Direct
    49599,49599,49599
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0.0000000000001088Direct
    52540,51045,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.000000000007522Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.00000000001338Direct
    47031,50729,55550
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0000000004735Direct
    47986,47986,52540
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0000000141Direct
    47031,50729,56112
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000001738Direct
    50044,48065,50729
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.00000001759Direct
    57184,57184,63825
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.00000002304Direct
    63825,57184,57184
  • 63825 - YWTD domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.00000002304Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0000001701Direct
    57630,57184,49899
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0000003948Direct
    57196,57196,100895
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 100895 - Kazal-type serine protease inhibitors
  • 0.0000008444Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000001132Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.000002122Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.000002612Direct
    56112,82615,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0.000003748Direct
    57184,57196,49899
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000003772Direct
    57630,57184,57196
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.000003772Direct
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.00001254Direct
    82919,53300,81995
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0.00001552Direct
    50729,49562,48350
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.000017Direct
    49562,54236,54236
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0.00002262Direct
    46565,52833,52833
  • 46565 - Chaperone J-domain
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00002262Direct
    50156,52540,51045
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.00002528Direct
    51905,51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.00006883Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.0000906Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0.0000906Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0002349Direct
    160481,52540,52540
  • 160481 - BRK domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0002462Direct
    55550,50044,51695
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 0.0009723Direct
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.04918Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.6112Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 1Inherited
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.001763Inherited
    57889,57889,49562
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.04918Inherited
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.08864Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.07716Inherited
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0.323Inherited
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.323Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.251Inherited
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.009436Inherited
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.01996Inherited
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 1Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.1141Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.1141Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.00123Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.5401Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.8373Inherited
    46966,46966,47473
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 47473 - EF-hand
  • 0.2329Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.4761Inherited
    57581,57184,57196
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.003454Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.004317Inherited
    57184,57581,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57581 - TB module/8-cys domain
  • 0.005907Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.006247Inherited
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.007478Inherited
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.01031Inherited
    57196,57184,49899
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.008356Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.03618Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0279Inherited
    57581,57196,57184
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001176Inherited
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.001548Inherited
    57581,57581,57184
  • 57581 - TB module/8-cys domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.002135Inherited
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.002256Inherited
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.002536Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3257Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.4239Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.5401Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.671Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.9068Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.1285Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3257Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.323Inherited
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0.005171Inherited
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2461Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1308Inherited
    55550,50044,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.671Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
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