SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Biological Process (BP): negative regulation of biological process

(show info)

Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + 3:   biological_process [GO:0008150] <24>
+ + 2:   biological regulation [GO:0065007] <5>(165|190) (757|933|542)
+ 1:   regulation of biological process [GO:0050789] <34>(155|176) (709|883|505)
0:   negative regulation of biological process [GO:0048519] <52>(72|76) (445|449|253)
- 1:   negative regulation of multicellular organismal process [GO:0051241] <147>(14|12) (183|136|79)
- 1:   negative regulation of developmental process [GO:0051093] <84>(8|7) (150|118|68)
- 1:   negative regulation of cellular process [GO:0048523] <65>(61|62) (404|394|222)
- 1:   negative regulation of response to stimulus [GO:0048585] <59>(20|17) (222|187|108)
- 1:   negative regulation of transport [GO:0051051] <41>(11|13) (89|49|22)
- 1:   negative regulation of multi-organism process [GO:0043901] <39>(4|3) (44|17|3)
- 1:   negative regulation of reproductive process [GO:2000242] <32>(2|2) (24|9|2)
- 1:   negative regulation of homeostatic process [GO:0032845] <23>(3|3) (35|21|10)
- 1:   negative regulation of immune system process [GO:0002683] <19>(7|6) (86|54|29)
- 1:   negative regulation of cellular protein localization [GO:1903828] <18>(2|4) (39|23|12)
- 1:   negative regulation of metabolic process [GO:0009892] <15>(36|36) (283|233|116)
- 1:   negative regulation of behavior [GO:0048521] <11>(0|0) (2|0|0)
- 1:   negative regulation of locomotion [GO:0040013] <11>(3|2) (50|39|26)
- 1:   negative regulation of signaling [GO:0023057] <10>(13|10) (193|165|90)
- 1:   negative regulation of action potential [GO:0045759] <6>(0|0) (2|0|0)
- 1:   negative regulation of growth [GO:0045926] <6>(6|6) (57|37|17)
- 1:   negative regulation of asexual reproduction [GO:1903665] <5>(0|0) (1|1|0)
- 1:   negative regulation of developmental pigmentation [GO:0048086] <5>(0|0) (1|1|0)
- 1:   negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433] <4>(4|3) (21|20|9)
- 1:   negative regulation of cell killing [GO:0031342] <3>(1|2) (7|3|1)
- 1:   negative regulation of circadian rhythm [GO:0042754] <3>(0|0) (6|2|0)
- 1:   negative regulation of establishment of protein localization [GO:1904950] <3>(5|5) (47|26|14)
- 1:   negative regulation of membrane depolarization [GO:1904180] <3>(0|0) (0|0|0)
- 1:   negative regulation of intracellular mRNA localization [GO:1904581] <2>(0|0) (0|0|0)
- 1:   negative regulation of lipid localization [GO:1905953] <2>(3|2) (10|2|1)
- 1:   negative regulation of ribonucleoprotein complex localization [GO:2000198] <2>(0|0) (0|0|0)
- 1:   negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098] <1>(0|0) (1|0|0)
- 1:   negative regulation of hemostasis [GO:1900047] <1>(3|3) (14|11|5)
- 1:   negative regulation of nitrogen utilization [GO:0045847] <1>(0|0) (0|0|0)
- 1:   negative regulation of 3'-UTR-mediated mRNA stabilization [GO:1905869](0|0) (0|0|0)
- 1:   negative regulation of GTPase activity [GO:0034260](0|0) (9|3|1)
- 1:   negative regulation of RNA binding transcription factor activity [GO:1905256](0|0) (0|0|0)
- 1:   negative regulation of cohesin unloading [GO:1905338](0|0) (0|0|0)
- 1:   negative regulation of dosage compensation by inactivation of X chromosome [GO:1900096](0|0) (0|0|0)
- 1:   negative regulation of establishment of RNA localization to telomere [GO:1904911](0|0) (0|0|0)
- 1:   negative regulation of establishment of macromolecular complex localization to telomere [GO:1904914](0|0) (0|0|0)
- 1:   negative regulation of fibrinolysis [GO:0051918](0|0) (1|0|0)
- 1:   negative regulation of ligand-dependent nuclear receptor transcription coactivator activity [GO:2000326](0|0) (1|0|0)
- 1:   negative regulation of long term synaptic depression [GO:1900453](0|0) (1|1|0)
- 1:   negative regulation of long-term synaptic potentiation [GO:1900272](0|0) (1|0|0)
- 1:   negative regulation of maintenance of permeability of blood-brain barrier [GO:1905604](0|0) (0|0|0)
- 1:   negative regulation of membrane hyperpolarization [GO:1902631](0|0) (0|0|0)
- 1:   negative regulation of mitotic telomere tethering at nuclear periphery [GO:1904537](0|0) (0|0|0)
- 1:   negative regulation of phosphorus utilization [GO:0045942](0|0) (0|0|0)
- 1:   negative regulation of proteasome-activating ATPase activity [GO:1902886](0|0) (0|0|0)
- 1:   negative regulation of protein localization to cell-cell adherens junction [GO:1904703](0|0) (0|0|0)
- 1:   negative regulation of protein localization to presynapse [GO:1905385](0|0) (0|0|0)
- 1:   negative regulation of receptor localization to synapse [GO:1902684](0|0) (0|0|0)
- 1:   negative regulation of short-term synaptic potentiation [GO:1905513](0|0) (0|0|0)
- 1:   negative regulation of sulfur utilization [GO:0045882](0|0) (0|0|0)
- 1:   negative regulation of telomerase RNA localization to Cajal body [GO:1904873](0|0) (0|0|0)
- 1:   release of cytoplasmic sequestered NF-kappaB [GO:0008588](0|0) (3|2|1)


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
4-helical cytokines0.0000000036720.000001661Direct
Cystatin/monellin0.00083020.00001786Direct
Cytidine deaminase-like0.000000077420.0000004696Direct
Inhibitor of apoptosis (IAP) repeat0.000000026920Direct
Insulin-like0.00014520.000000000008497Direct
Kazal-type serine protease inhibitors0.000083080.0000005174Direct
Lipocalins0.000025390.0006143Direct
Metallothionein00Direct
PhoU-like00.000000000000001925Direct
Ribonuclease H-like0.0000000022670.0000000000004264Direct
Serpins0.00000000000031780.000000000000001925Direct
Stathmin0.00012890.0002304Direct
The spindle assembly checkpoint protein mad20.00000034720.0000001333Direct
Ubiquitin-like10.002731Inherited
Class I glutamine amidotransferase-like0.30331Inherited
Metalloproteases ("zincins"), catalytic domain0.4490.6337Inherited
Protein kinase-like (PK-like)10.8447Inherited
S-adenosyl-L-methionine-dependent methyltransferases11Inherited
TPR-like11Inherited
KRAB domain (Kruppel-associated box)0.28131Inherited
Family A G protein-coupled receptor-like11Inherited
(Phosphotyrosine protein) phosphatases II0.16310Inherited
Carbohydrate phosphatase0.036220.7872Inherited
EF-hand11Inherited
WD40 repeat-like0.17720.3393Inherited
Blood coagulation inhibitor (disintegrin)0.0055580.01785Inherited
Trypsin-like serine proteases0.44710.0000002911Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)11Inherited
Nqo5-like0.00077350.07642Inherited
Bcl-2 inhibitors of programmed cell death0.0046250.001401Inherited
Metallo-dependent hydrolases0.00000000015080.6377Inherited
Cysteine proteinases0.006940.004424Inherited
Profilin (actin-binding protein)0.017990.02831Inherited
Calponin-homology domain, CH-domain0.23820.01995Inherited
Subunits of heterodimeric actin filament capping protein Capz0.021820.0216Inherited
Immunoglobulin11Inherited
Snake toxin-like0.38250.4422Inherited
Radical SAM enzymes0.87551Inherited
Ankyrin repeat0.0002260.001703Inherited
Nucleotide-diphospho-sugar transferases0.98671Inherited
Cu,Zn superoxide dismutase-like0.00058090.02912Inherited
Cell growth inhibitor/plasmid maintenance toxic component0.022960.03403Inherited
UDP-Glycosyltransferase/glycogen phosphorylase11Inherited
NAD(P)-linked oxidoreductase11Inherited
Histone-fold0.72320.9812Inherited
HLH, helix-loop-helix DNA-binding domain0.024990.8499Inherited
Cytochrome P4500.042361Inherited
DEATH domain0.00000051660.05204Inherited
Nuclear receptor ligand-binding domain0.003690.2922Inherited
PIN domain-like0.0040240.000991Inherited
eIF4e-like0.058920.8531Inherited
Pentein0.088290.5842Inherited
Interleukin 8-like chemokines0.016960.2657Inherited
P-loop containing nucleoside triphosphate hydrolases11Inherited
YjgF-like0.0034870.4954Inherited
TIMP-like0.00000034720.02698Inherited
N-acetylmuramoyl-L-alanine amidase-like0.081040.0376Inherited
"Winged helix" DNA-binding domain0.00029360.01092Inherited
Ribosome inactivating proteins (RIP)0.00028590.001532Inherited
C-type lectin-like0.059621Inherited
(Trans)glycosidases0.14141Inherited
PDZ domain-like0.044351Inherited
Annexin0.0064970.0204Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.33750.6991Inherited
alpha/beta-Hydrolases11Inherited
Mitochondrial carrier11Inherited
Sm-like ribonucleoproteins0.00082230.4205Inherited
RelE-like0.000043410.003185Inherited
RNase A-like0.000018540.02787Inherited
Ferritin-like0.0079280.8138Inherited
Nudix0.2330.7677Inherited
ARM repeat0.089220.002741Inherited


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
AF0104-like0.00077840.0008604Direct
Bee venom hyaluronidase0.0000000000000022720Direct
CAF1-like ribonuclease00.00000000000001313Direct
Forkhead DNA-binding domain0.00037150.00001159Direct
FUR-like0.000000040740.000000422Direct
Inhibitor of apoptosis (IAP) repeat0.000000024760Direct
Insulin-like0.00013520.000000000008209Direct
Interferons/interleukin-10 (IL-10)0.0000002580.000002377Direct
Long-chain cytokines0.00000015380.000003622Direct
Metallothionein00Direct
Ovomucoid domain III-like0.00074320.000002356Direct
PhoU-like00Direct
Renal dipeptidase00.00000000001191Direct
Retinol binding protein-like0.0000030510.00003145Direct
RPF-like00Direct
Serpins0.000000000000340.000000000000001589Direct
Stathmin0.00011660.0002005Direct
The spindle assembly checkpoint protein mad20.00000031560.0000000009657Direct
Tissue inhibitor of metalloproteinases, TIMP0.000000000000062890.0000006873Direct
Astacin0.10950.0006303Inherited
Protein kinases, catalytic subunit10.8049Inherited
PP1699/LP2961-like0.029910.2386Inherited
KRAB domain (Kruppel-associated box)0.34141Inherited
Rhodopsin-like11Inherited
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0.040470.7984Inherited
WD40-repeat0.33140.5228Inherited
Blood coagulation inhibitor (disintegrin)0.0071480.04286Inherited
Eukaryotic proteases0.49870.2019Inherited
Proteasome subunits0.97631Inherited
DJ-1/PfpI0.017980.5898Inherited
Nqo5-like0.0011920.07837Inherited
Bcl-2 inhibitors of programmed cell death0.0045770.001295Inherited
Glyoxalase I (lactoylglutathione lyase)0.00030180.1971Inherited
Thioesterases0.0033250.02314Inherited
Short-chain cytokines0.84931Inherited
Fibroblast growth factors (FGF)0.94621Inherited
Papain-like0.00020730.2986Inherited
Profilin (actin-binding protein)0.016690.02553Inherited
Calponin-homology domain, CH-domain0.22310.01921Inherited
Capz alpha-1 subunit0.007640.01851Inherited
Capz beta-1 subunit0.1390.1855Inherited
Cell cycle arrest protein BUB30.11950.1693Inherited
Calmodulin-like11Inherited
MoCo biosynthesis proteins0.0034420.3943Inherited
Ankyrin repeat0.00011450.002161Inherited
beta 1,4 galactosyltransferase (b4GalT1)0.0033250.2047Inherited
Cu,Zn superoxide dismutase-like0.00054010.0546Inherited
Kid/PemK0.021110.0306Inherited
UDPGT-like0.85721Inherited
Aldo-keto reductases (NADP)11Inherited
Nucleosome core histones0.63720.9933Inherited
HLH, helix-loop-helix DNA-binding domain0.023660.8142Inherited
Cytochrome P4500.08281Inherited
Nuclear receptor ligand-binding domain0.0033250.2827Inherited
G proteins11Inherited
Translation initiation factor eIF4e0.075920.8741Inherited
Interleukin 8-like chemokines0.017140.2518Inherited
Ubiquitin-related0.57330.08513Inherited
Cystatins0.0099330.1358Inherited
YjgF/L-PSP0.0049050.5343Inherited
Tetratricopeptide repeat (TPR)0.96560.4033Inherited
Dual specificity phosphatase-like0.087170.00000000000008083Inherited
N-acetylmuramoyl-L-alanine amidase-like0.074860.03412Inherited
Plant cytotoxins0.00014030.001244Inherited
Ribosome anti-association factor eIF6 (aIF6)0.000072590.002145Inherited
C-type lectin domain0.035141Inherited
Annexin0.006180.04717Inherited
C5 cytosine-specific DNA methylase, DCM0.00077840.2873Inherited
B56-like0.035140.0003097Inherited
Mitochondrial carrier11Inherited
Cathelicidin motif0.000020140.005329Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0043790.3648Inherited
Ribonuclease A-like0.000017130.02536Inherited
Ferritin0.0008610.1151Inherited
MutT-like0.10170.4993Inherited
SH2 domain0.36481Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this GO term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
(Phosphotyrosine protein) phosphatases II0Direct
Metallothionein0Direct
Cryptochrome/photolyase FAD-binding domain0Direct
Cryptochrome/photolyase, N-terminal domain0Direct
dsRNA-binding domain-like0Direct
Cystine-knot cytokines0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
PAZ domain0Direct
Plant inhibitors of proteinases and amylases0Direct
FLJ32549 C-terminal domain-like0Direct
Domain from hypothetical 2610208m17rik protein0Direct
FLJ32549 domain-like0Direct
PhoU-like9.676e-16Direct
Serpins9.676e-16Direct
Soluble domain of poliovirus core protein 3a9.676e-16Direct
RNase III domain-like0.000000000000001898Direct
GAS2 domain-like0.000000000000007352Direct
HMG-box0.0000000000000573Direct
Ribonuclease H-like0.0000000000002301Direct
Protein serine/threonine phosphatase 2C, C-terminal domain0.0000000000006812Direct
Hairpin loop containing domain-like0.00000000000333Direct
Insulin-like0.000000000004765Direct
Orange domain-like0.000000000007301Direct
SAND domain-like0.000000000008014Direct
PAP/OAS1 substrate-binding domain0.00000000003177Direct
Chromo domain-like0.00000000004753Direct
LexA/Signal peptidase0.00000000006295Direct
SPOC domain-like0.0000000001628Direct
Putative DNA-binding domain0.0000000002113Direct
Dcp2 domain-like0.0000000003606Direct
mRNA decapping enzyme DcpS N-terminal domain0.00000000052Direct
Kringle-like0.0000000009686Direct
p53 tetramerization domain0.000000001116Direct
RING/U-box0.000000001316Direct
Positive stranded ssRNA viruses0.000000006884Direct
beta-beta-alpha zinc fingers0.0000000357Direct
The spindle assembly checkpoint protein mad20.00000008297Direct
SET domain0.0000001049Direct
Trypsin-like serine proteases0.0000001832Direct
Cytidine deaminase-like0.0000002971Direct
Kazal-type serine protease inhibitors0.0000003278Direct
Suppressor of Fused, N-terminal domain0.000000553Direct
Tumor suppressor gene product Apc0.000000553Direct
N-terminal coiled coil domain from apc0.000000553Direct
BRCT domain0.000000769Direct
4-helical cytokines0.00000107Direct
Serum albumin-like0.000001148Direct
PAH2 domain0.000001408Direct
Plakin repeat0.000003148Direct
PP2C-like0.000003678Direct
BTG domain-like0.000005006Direct
Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain0.000005993Direct
Cystatin/monellin0.0000119Direct
AXH domain0.00002156Direct
SMAD/FHA domain0.00002941Direct
DNA/RNA polymerases0.00003168Direct
Arginase/deacetylase0.00004688Direct
Trimerization domain of TRAF0.00005921Direct
Tudor/PWWP/MBT0.00007776Direct
p53-like transcription factors0.00007917Direct
C-terminal domain of Ku800.00008674Direct
SAP domain0.00009418Direct
Stathmin0.0001596Direct
RNA-binding domain, RBD0.0001877Direct
FAT domain of focal adhesion kinase0.0002347Direct
Viral glycoprotein, central and dimerisation domains0.0002377Direct
YVTN repeat-like/Quinoprotein amine dehydrogenase0.0003397Direct
Bowman-Birk inhibitor, BBI0.0003917Direct
F1 ATPase inhibitor, IF1, C-terminal domain0.0003955Direct
Lipocalins0.0004332Direct
N-terminal domain of cbl (N-cbl)0.0004873Direct
SMAD MH1 domain0.0005761Direct
Notch domain0.0006089Direct
ASF1-like0.0006523Direct
PIN domain-like0.0007053Direct
Regulatory factor Nef0.0008157Direct
Rhodanese/Cell cycle control phosphatase0.000849Direct
Actin depolymerizing proteins0.0009277Direct
Connexin430.0009517Direct
Iron-dependent repressor protein, dimerization domain0.0009602Direct
GST C-terminal domain-like1Inherited
Ubiquitin-like0.00198Inherited
Thioredoxin-like1Inherited
WWE domain0.8775Inherited
PABC (PABP) domain0.1785Inherited
ADP-ribosylation0.897Inherited
Type II DNA topoisomerase0.3104Inherited
RuvA domain 2-like0.4779Inherited
Tex N-terminal region-like0.08779Inherited
Telomeric repeat binding factor (TRF) dimerisation domain0.07924Inherited
Restriction endonuclease-like0.7795Inherited
Clavaminate synthase-like0.06087Inherited
ARID-like0.4375Inherited
Nucleic acid-binding proteins0.005641Inherited
Nuclear receptor ligand-binding domain0.2416Inherited
Mitochondrial carrier1Inherited
Thiolase-like1Inherited
Class II MHC-associated invariant chain ectoplasmic trimerization domain0.04625Inherited
Nqo5-like0.06008Inherited
Fibrinogen coiled-coil and central regions0.07445Inherited
Leucine zipper domain1Inherited
TNF receptor-like0.311Inherited
Cyclophilin-like1Inherited
Prefoldin0.5006Inherited
lambda repressor-like DNA-binding domains0.05325Inherited
UDP-Glycosyltransferase/glycogen phosphorylase1Inherited
Sec63 N-terminal domain-like0.9771Inherited
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0.8958Inherited
Class I glutamine amidotransferase-like1Inherited
Metalloproteases ("zincins"), catalytic domain0.5472Inherited
Hedgehog/intein (Hint) domain0.003339Inherited
Hedgehog/DD-peptidase0.006597Inherited
SRF-like1Inherited
BPTI-like0.2031Inherited
F-box domain1Inherited
beta-sandwich domain of Sec23/240.8816Inherited
Integrin domains1Inherited
FabD/lysophospholipase-like1Inherited
Metallo-dependent hydrolases0.5507Inherited
Concanavalin A-like lectins/glucanases1Inherited
Annexin0.01544Inherited
Cap-Gly domain0.4545Inherited
Growth factor receptor domain0.217Inherited
UBC-like0.5059Inherited
Frizzled cysteine-rich domain0.1745Inherited
Myosin rod fragments0.1124Inherited
Voltage-gated potassium channels1Inherited
CAD & PB1 domains0.3821Inherited
Transducin (alpha subunit), insertion domain1Inherited
Neurotransmitter-gated ion-channel transmembrane pore1Inherited
Nicotinic receptor ligand binding domain-like1Inherited
SNARE fusion complex1Inherited
BAG domain0.01452Inherited
L30e-like0.8856Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3362Inherited
alpha/beta-Hydrolases1Inherited
DPP6 N-terminal domain-like1Inherited
G protein-binding domain0.352Inherited
GAT-like domain0.7372Inherited
Nitrite and sulphite reductase 4Fe-4S domain-like0.262Inherited
LanC-like0.6589Inherited
DHH phosphoesterases0.6047Inherited
HSP90 C-terminal domain0.8174Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase1Inherited
Histone-fold0.884Inherited
Macro domain-like0.9713Inherited
DNA-glycosylase0.6766Inherited
Bcl-2 inhibitors of programmed cell death0.001003Inherited
Cytokine1Inherited
Multidrug resistance efflux transporter EmrE1Inherited
TGS-like1Inherited
HSP20-like chaperones1Inherited
Bactericidal permeability-increasing protein, BPI0.4265Inherited
Doublecortin (DC)0.5692Inherited
TB module/8-cys domain0.3351Inherited
EGF/Laminin0.6039Inherited
Homeodomain-like0.4244Inherited
Thyroglobulin type-1 domain0.03061Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.6481Inherited
FAD/NAD(P)-binding domain1Inherited
PX domain1Inherited
Serine protease inhibitors0.9096Inherited
C-terminal domain of PLC-beta0.6959Inherited
Integrin alpha N-terminal domain0.1376Inherited
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0.0674Inherited
Ribosomal protein S5 domain 2-like0.8866Inherited
PDZ domain-like1Inherited
Eukaryotic type KH-domain (KH-domain type I)0.1161Inherited
WW domain0.001727Inherited
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 30.01235Inherited
Ribonuclease PH domain 2-like0.006873Inherited
Metallo-dependent phosphatases1Inherited
Kelch motif1Inherited
POZ domain0.08309Inherited
CRAL/TRIO N-terminal domain0.8756Inherited
CRAL/TRIO domain0.01634Inherited
PYP-like sensor domain (PAS domain)1Inherited
GTPase activation domain, GAP1Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)1Inherited
Cysteine-rich domain1Inherited
DEATH domain0.0404Inherited
SH2 domain0.9956Inherited
SOCS box-like0.003825Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
E set domains0.8626Inherited
Zn2/Cys6 DNA-binding domain1Inherited
KA1-like0.1204Inherited
Cadherin-like1Inherited
alpha-catenin/vinculin-like0.9091Inherited
UBA-like0.1907Inherited
Nitric oxide (NO) synthase oxygenase domain0.3351Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain1Inherited
Riboflavin synthase domain-like1Inherited
Cysteine-rich DNA binding domain, (DM domain)0.5895Inherited
AraD/HMP-PK domain-like0.5353Inherited
PLC-like phosphodiesterases0.5956Inherited
IP3 receptor type 1 binding core, domain 20.02199Inherited
ERO1-like0.03675Inherited
MIR domain0.1928Inherited
Interleukin 8-like chemokines0.2186Inherited
EF-hand1Inherited
SH3-domain1Inherited
Anthrax protective antigen0.1868Inherited
Endosomal sorting complex assembly domain0.05683Inherited
DUSP-like1Inherited
VPS28 C-terminal domain-like0.001796Inherited
Radical SAM enzymes1Inherited
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain0.1738Inherited
TNF-like1Inherited
Eferin C-derminal domain-like0.3581Inherited
Rhomboid-like0.01114Inherited
CSL zinc finger0.5375Inherited
GLA-domain0.02349Inherited
HD-domain/PDEase-like0.4827Inherited
GAF domain-like0.06985Inherited
Ankyrin repeat0.001224Inherited
Subunits of heterodimeric actin filament capping protein Capz0.01638Inherited
C-terminal, gelsolin-like domain of Sec23/240.3681Inherited
Profilin (actin-binding protein)0.02163Inherited
VHP, Villin headpiece domain0.04894Inherited
BAR/IMD domain-like0.04611Inherited
Skp1 dimerisation domain-like0.1248Inherited
Ribosomal protein L130.003925Inherited
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain0.5692Inherited
TSP type-3 repeat0.003717Inherited
HR1 repeat0.305Inherited
SAM/Pointed domain0.2033Inherited
LDL receptor-like module1Inherited
TAFH domain-like0.5895Inherited
Composite domain of metallo-dependent hydrolases1Inherited
YWTD domain0.8061Inherited
FnI-like domain0.1194Inherited
Galactose-binding domain-like1Inherited
RUN domain-like0.7109Inherited
tRNA-binding arm0.04125Inherited
Acyl-CoA dehydrogenase NM domain-like1Inherited
Acyl-CoA dehydrogenase C-terminal domain-like1Inherited
DNA repair protein MutS, domain II0.2064Inherited
Flavoproteins1Inherited
Ypt/Rab-GAP domain of gyp1p0.9871Inherited
Cation efflux protein cytoplasmic domain-like0.7683Inherited
Hemopexin-like domain0.01569Inherited
PGBD-like0.05678Inherited
PA domain1Inherited
AF0104/ALDC/Ptd012-like0.01486Inherited
Surp module (SWAP domain)0.3606Inherited
TSP-1 type 1 repeat0.4623Inherited
L domain-like1Inherited
Heme oxygenase-like0.5811Inherited
PR-1-like1Inherited
Subtilisin-like1Inherited
Nucleotide-diphospho-sugar transferases1Inherited
ACP-like1Inherited
Acetyl-CoA synthetase-like1Inherited
Spermadhesin, CUB domain1Inherited
Rap/Ran-GAP0.03392Inherited
Bet v1-like1Inherited
Cullin repeat-like0.2709Inherited
Cullin homology domain0.06131Inherited
Carbohydrate phosphatase0.6915Inherited
Calcium ATPase, transmembrane domain M1Inherited
Metal cation-transporting ATPase, ATP-binding domain N1Inherited
Calcium ATPase, transduction domain A1Inherited
HAD-like1Inherited
Cell growth inhibitor/plasmid maintenance toxic component0.02611Inherited
Complement control module/SCR domain1Inherited
MIT domain0.4265Inherited
Acyl-CoA N-acyltransferases (Nat)1Inherited
HIT/MYND zinc finger-like0.01141Inherited
Geminin coiled-coil domain0.34Inherited
L27 domain0.9765Inherited
Kix domain of CBP (creb binding protein)0.007198Inherited
TAZ domain0.2226Inherited
TRAF domain-like0.3934Inherited
Tropomyosin1Inherited
Actin-like ATPase domain1Inherited
Carbonic anhydrase1Inherited
Cupredoxins1Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.4079Inherited
A DNA-binding domain in eukaryotic transcription factors1Inherited
Periplasmic binding protein-like II1Inherited
HCP-like1Inherited
PH domain-like1Inherited
ENTH/VHS domain0.2841Inherited
DNA-binding protein LAG-1 (CSL)0.8813Inherited
Thioesterase/thiol ester dehydrase-isomerase1Inherited
Bromodomain0.3318Inherited
Hect, E3 ligase catalytic domain0.002017Inherited
HLH, helix-loop-helix DNA-binding domain0.7522Inherited
DNase I-like0.01354Inherited
Regulator of G-protein signaling, RGS0.9094Inherited
DnaJ/Hsp40 cysteine-rich domain0.1971Inherited
HSP40/DnaJ peptide-binding domain0.2276Inherited
(Trans)glycosidases1Inherited
Second domain of FERM0.02153Inherited
Moesin tail domain0.1075Inherited
Formin homology 2 domain (FH2 domain)1Inherited
FAD-binding/transporter-associated domain-like1Inherited
DNA repair protein MutS, domain III0.01756Inherited
Nucleoplasmin-like core domain0.01804Inherited
SRCR-like0.06537Inherited
Cu,Zn superoxide dismutase-like0.02226Inherited
TATA-box binding protein-like0.5482Inherited
Heparin-binding domain from vascular endothelial growth factor0.008071Inherited
Delta-sleep-inducing peptide immunoreactive peptide0.08779Inherited
Tautomerase/MIF0.2433Inherited
Colipase-like0.2643Inherited
Fibrinogen C-terminal domain-like0.02571Inherited
Calpain large subunit, middle domain (domain III)0.01073Inherited
Synuclein0.3773Inherited
Acid proteases1Inherited
SWIB/MDM2 domain0.305Inherited
Family A G protein-coupled receptor-like1Inherited
SEA domain0.1074Inherited
Immunoglobulin1Inherited
CCCH zinc finger0.007272Inherited
Multidrug efflux transporter AcrB transmembrane domain0.5847Inherited
Nucleotide cyclase1Inherited
NAD kinase/diacylglycerol kinase-like1Inherited
Cysteine proteinases0.003242Inherited
Ran binding protein zinc finger-like0.1741Inherited
DhaL-like0.0674Inherited
DAK1/DegV-like0.2073Inherited
Blood coagulation inhibitor (disintegrin)0.01346Inherited
RCC1/BLIP-II0.07955Inherited
Plexin repeat1Inherited
Sema domain1Inherited
Sec7 domain1Inherited
Fic-like0.7317Inherited
Supernatant protein factor (SPF), C-terminal domain0.9488Inherited
SIS domain0.4566Inherited
Chaperone J-domain0.7982Inherited
N-acetylmuramoyl-L-alanine amidase-like0.02892Inherited
Translation proteins SH3-like domain1Inherited
Toll/Interleukin receptor TIR domain1Inherited
Mitochondrial glycoprotein MAM33-like0.07779Inherited
NAD(P)-linked oxidoreductase1Inherited
Satiety factor CART (cocaine and amphetamine regulated transcript)0.009224Inherited
Cytochrome b5-like heme/steroid binding domain1Inherited
RuBisCo LSMT C-terminal, substrate-binding domain0.4494Inherited
RNI-like1Inherited
Cytochrome P4501Inherited
eIF2alpha middle domain-like0.379Inherited
eIF-2-alpha, C-terminal domain0.379Inherited
Class II aaRS and biotin synthetases1Inherited
ACT-like1Inherited
ClpS-like0.4494Inherited
vWA-like1Inherited
DNA-binding domain1Inherited
post-AAA+ oligomerization domain-like1Inherited
Apolipoprotein A-I0.717Inherited
Elafin-like0.003784Inherited
C-type lectin-like1Inherited
MHC antigen-recognition domain1Inherited
Fibronectin type III1Inherited
RL5-like0.2731Inherited
HIT-like0.3193Inherited
DNA repair protein MutS, domain I0.03861Inherited
Ribbon-helix-helix0.06934Inherited
DBL homology domain (DH-domain)1Inherited
Spectrin repeat0.1117Inherited
EB1 dimerisation domain-like0.003717Inherited
Calponin-homology domain, CH-domain0.01509Inherited
FKBP-like0.6691Inherited
Quinoprotein alcohol dehydrogenase-like0.7897Inherited
YjeF N-terminal domain-like0.5425Inherited
Periplasmic binding protein-like I1Inherited
Pseudo ankyrin repeat-like0.7317Inherited
LCCL domain0.6498Inherited
Pentapeptide repeat-like0.7524Inherited
cAMP-binding domain-like1Inherited
Tetraspanin1Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.4091Inherited
Lipoxigenase0.03163Inherited
TIMP-like0.02059Inherited
Ras GEF1Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
Ribosomal protein L25-like0.2064Inherited
YjgF-like0.4211Inherited
eIF4e-like0.7553Inherited
AhpD-like0.01539Inherited
RelE-like0.002317Inherited
Ribosome inactivating proteins (RIP)0.0011Inherited
HAND domain of the nucleosome remodeling ATPase ISWI0.6102Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Nudix0.6728Inherited
B-box zinc-binding domain0.02335Inherited
Pentein0.5015Inherited
NHL repeat0.3466Inherited
Retrovirus zinc finger-like domains0.09637Inherited
ABC transporter transmembrane region1Inherited
Translin0.1326Inherited
TPR-like1Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.608Inherited
Gamma-glutamyl cyclotransferase-like0.935Inherited
PTPA-like0.07234Inherited
Phosphoglycerate mutase-like1Inherited
Nucleotidyltransferase0.006369Inherited
Sm-like ribonucleoproteins0.3542Inherited
VHL0.07234Inherited
LEM domain0.02172Inherited
CheY-like1Inherited
Homodimeric domain of signal transducing histidine kinase1Inherited
FYVE/PHD zinc finger0.003559Inherited
DHS-like NAD/FAD-binding domain0.003361Inherited
Snake toxin-like0.3735Inherited
ARM repeat0.001987Inherited
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)0.06934Inherited
CCHHC domain0.001891Inherited
Soluble quinoprotein glucose dehydrogenase0.1644Inherited
Proteasome activator0.4025Inherited
WRKY DNA-binding domain0.3952Inherited
Alanine racemase C-terminal domain-like0.2802Inherited
PLP-binding barrel0.9493Inherited
Nitrite/Sulfite reductase N-terminal domain-like0.1277Inherited
Clathrin heavy-chain terminal domain0.155Inherited
Retrovirus capsid dimerization domain-like0.01534Inherited
Tetracyclin repressor-like, C-terminal domain0.001842Inherited
KRAB domain (Kruppel-associated box)0.9957Inherited
BRK domain-like0.001912Inherited
BAH domain0.004965Inherited
A middle domain of Talin 10.03675Inherited
RNase A-like0.02128Inherited
Ferritin-like0.7169Inherited
HRDC-like0.004481Inherited
Mitotic arrest deficient-like 1, Mad10.03386Inherited
Fzo-like conserved region0.004123Inherited
Translation proteins1Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain1Inherited
"Winged helix" DNA-binding domain0.008127Inherited
Transcription factor STAT-4 N-domain0.25Inherited
STAT0.1075Inherited
Alkaline phosphatase-like0.5143Inherited
Ribosomal L27 protein-like0.3585Inherited
Plus3-like0.1621Inherited
Carboxypeptidase regulatory domain-like0.4494Inherited
Uracil-DNA glycosylase-like0.598Inherited
E2F-DP heterodimerization region0.0137Inherited
Cyclin-like0.7852Inherited
14-3-3 protein0.5331Inherited
WD40 repeat-like0.2827Inherited
Polo-box domain0.1785Inherited
Protein kinase-like (PK-like)0.747Inherited
DNA clamp0.1031Inherited
JAB1/MPN domain0.003044Inherited

(show details)