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Biological Process (BP): modulation of chemical synaptic transmission

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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   biological_process [GO:0008150] <24>
+ + + 3:   biological regulation [GO:0065007] <5>(165|190) (757|933|542)
+ + 2:   regulation of biological process [GO:0050789] <34>(155|176) (709|883|505)
+ + 2:   regulation of cellular process [GO:0050794] <58>(138|154) (661|802|451)
+ 1:   regulation of cell communication [GO:0010646] <25>(42|44) (331|347|194)
+ 1:   regulation of signaling [GO:0023051] <13>(42|44) (331|349|197)
0:   modulation of chemical synaptic transmission [GO:0050804] <22>(2|2) (64|49|18)
- 1:   positive regulation of synaptic transmission [GO:0050806] <13>(0|0) (25|18|6)
- 1:   regulation of synaptic plasticity [GO:0048167] <11>(0|1) (35|29|10)
- 1:   negative regulation of synaptic transmission [GO:0050805] <10>(0|0) (15|8|2)
- 1:   regulation of neurotransmitter secretion [GO:0046928] <9>(0|0) (17|12|6)
- 1:   modulation of excitatory postsynaptic potential [GO:0098815] <5>(0|0) (15|10|5)
- 1:   regulation of synaptic transmission, cholinergic [GO:0032222] <4>(0|0) (4|1|0)
- 1:   trans-synaptic signaling, modulating synaptic transmission [GO:0099550] <4>(0|0) (0|0|0)
- 1:   regulation of synaptic transmission, dopaminergic [GO:0032225] <3>(1|0) (6|1|0)
- 1:   regulation of synaptic transmission, glutamatergic [GO:0051966] <3>(0|0) (9|7|3)
- 1:   regulation of synaptic transmission, glycinergic [GO:0060092] <3>(1|1) (1|0|0)
- 1:   modulation by symbiont of host synaptic transmission [GO:0044758] <2>(0|0) (0|0|0)
- 1:   regulation of neuromuscular synaptic transmission [GO:1900073] <2>(0|0) (5|3|2)
- 1:   regulation of protein catabolic process at synapse, modulating synaptic transmission [GO:0099574] <2>(0|0) (0|0|0)
- 1:   regulation of synaptic transmission, GABAergic [GO:0032228] <2>(0|0) (5|1|0)
- 1:   regulation of translation at synapse, modulating synaptic transmission [GO:0099547] <2>(0|0) (0|0|0)
- 1:   rhythmic synaptic transmission [GO:0060024] <2>(0|0) (1|0|0)
- 1:   modulation of inhibitory postsynaptic potential [GO:0098828] <1>(0|0) (5|0|0)
- 1:   regulation of postsynaptic neurotransmitter receptor activity [GO:0098962] <1>(0|0) (0|0|0)
- 1:   modification of synaptic structure, modulating synaptic transmission [GO:0099564](0|0) (0|0|0)
- 1:   protein catabolic process, modulating synaptic transmission [GO:0099546](0|0) (0|0|0)
- 1:   regulation of modification of synapse structure, modulating synaptic transmission [GO:0098987](0|0) (0|0|0)
- 1:   regulation of synaptic activity [GO:0060025](0|0) (4|0|0)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
SNF-like0.000000024680.00006031Direct
P-loop containing nucleoside triphosphate hydrolases0.00000000069970.9754Inherited


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
G proteins0.0000053050.0004604Direct
SNF-like0.000000013260.0001082Direct


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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
C2 domain (Calcium/lipid-binding domain, CaLB)0Direct
Periplasmic binding protein-like I0Direct
Periplasmic binding protein-like II0Direct
Voltage-gated potassium channels0Direct
PDZ domain-like0.00000000000002235Direct
FYVE/PHD zinc finger0.0000005029Direct
Nicotinic receptor ligand binding domain-like0.0000017Direct
CalX-like0.000002099Direct
Cadherin-like0.000002877Direct
cAMP-binding domain-like0.000006181Direct
NAD kinase/diacylglycerol kinase-like0.000007006Direct
SNARE fusion complex0.000007315Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000007919Direct
Polo-box domain0.00001645Direct
Peptidase/esterase 'gauge' domain0.00002548Direct
SNF-like0.00004089Direct
Spectrin repeat0.00004904Direct
t-snare proteins0.00005432Direct
Ankyrin repeat0.0000563Direct
beta-sandwich domain of Sec23/240.000132Direct
lambda repressor-like DNA-binding domains0.0001388Direct
SRF-like0.0002534Direct
Eukaryotic type KH-domain (KH-domain type I)0.0003818Direct
Homeodomain-like0.86Inherited
POZ domain0.05074Inherited
dsRNA-binding domain-like0.03077Inherited
Class II aaRS and biotin synthetases0.3227Inherited
UBC-like0.4466Inherited
Fibronectin type III1Inherited
Concanavalin A-like lectins/glucanases0.003564Inherited
RNA-binding domain, RBD0.008608Inherited
Cysteine-rich domain0.3376Inherited
alpha/beta-Hydrolases0.01831Inherited
Second domain of FERM0.669Inherited
P-loop containing nucleoside triphosphate hydrolases0.878Inherited
SH3-domain0.238Inherited
FAT domain of focal adhesion kinase0.01038Inherited
CAD & PB1 domains0.01157Inherited
SAM/Pointed domain0.00263Inherited
DEATH domain0.04737Inherited
BAR/IMD domain-like0.003579Inherited
TNF-like0.001973Inherited
Transducin (alpha subunit), insertion domain0.04956Inherited
Immunoglobulin1Inherited
WW domain0.676Inherited
RING/U-box1Inherited
NTF2-like0.006397Inherited
14-3-3 protein0.01445Inherited
Rap/Ran-GAP0.1104Inherited
Ras GEF0.2401Inherited
Protein kinase-like (PK-like)1Inherited
E set domains0.2031Inherited
p53-like transcription factors0.5624Inherited
Family A G protein-coupled receptor-like0.01304Inherited
Phoshotransferase/anion transport protein0.004196Inherited
PYP-like sensor domain (PAS domain)0.3298Inherited
Galactose-binding domain-like0.09375Inherited
Cystine-knot cytokines1Inherited
EGF/Laminin1Inherited
CRAL/TRIO domain0.09686Inherited
HLH, helix-loop-helix DNA-binding domain0.9005Inherited
WD40 repeat-like0.9297Inherited
Ubiquitin-like0.8379Inherited
Regulator of G-protein signaling, RGS1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0Direct
    81324,51735
  • 81324 - Voltage-gated potassium channels
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    50156,103657
  • 50156 - PDZ domain-like
  • 103657 - BAR/IMD domain-like
  • 0.000000000001415Direct
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.000000000003304Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.00000000001368Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.00000003036Direct
    54277,57889
  • 54277 - CAD & PB1 domains
  • 57889 - Cysteine-rich domain
  • 0.00000007384Direct
    54791,54791
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 0.00000108Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0.000002099Direct
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.000002099Direct
    56112,54427
  • 56112 - Protein kinase-like (PK-like)
  • 54427 - NTF2-like
  • 0.000002878Direct
    53850,81324
  • 53850 - Periplasmic binding protein-like II
  • 81324 - Voltage-gated potassium channels
  • 0.000003426Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.000006924Direct
    49313,49899
  • 49313 - Cadherin-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000007228Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000009723Direct
    46966,51045
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 0.00001645Direct
    51045,47473
  • 51045 - WW domain
  • 47473 - EF-hand
  • 0.00001645Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0.00001645Direct
    50993,53474
  • 50993 - Peptidase/esterase 'gauge' domain
  • 53474 - alpha/beta-Hydrolases
  • 0.00002548Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0.0001253Direct
    56112,50978
  • 56112 - Protein kinase-like (PK-like)
  • 50978 - WD40 repeat-like
  • 0.000223Direct
    64268,56112
  • 64268 - PX domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000223Direct
    81995,49417
  • 81995 - beta-sandwich domain of Sec23/24
  • 49417 - p53-like transcription factors
  • 0.000223Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0004288Direct
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.0004429Direct
    48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.0008484Direct
    56112,55681
  • 56112 - Protein kinase-like (PK-like)
  • 55681 - Class II aaRS and biotin synthetases
  • 0.0009195Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.09765Inherited
    47370,63748
  • 47370 - Bromodomain
  • 63748 - Tudor/PWWP/MBT
  • 0.004766Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.007169Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.004586Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.326Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.5484Inherited
    52058,52540
  • 52058 - L domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.004766Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2411Inherited
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01157Inherited
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0.01157Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04956Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.7529Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.8903Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.002351Inherited
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.001667Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.01714Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.002316Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.001667Inherited
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0.1497Inherited
    54236,48366
  • 54236 - Ubiquitin-like
  • 48366 - Ras GEF
  • 0.004729Inherited
    50729,49562
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.02784Inherited
    50729,50044
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.007583Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    81995,49417,81296
  • 81995 - beta-sandwich domain of Sec23/24
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0Direct
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.000002099Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000002677Direct
    53822,53850,81324
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 81324 - Voltage-gated potassium channels
  • 0.000003426Direct
    49313,49313,49899
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000005733Direct
    46966,51045,47473
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 47473 - EF-hand
  • 0.00001645Direct
    51045,47473,47473
  • 51045 - WW domain
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.00001645Direct
    47031,50729,56112
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00002548Direct
    47769,47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.00009603Direct
    46966,46966,51045
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 0.0001253Direct
    54768,54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.0001253Direct
    101288,50156,50044
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0.000223Direct
    48403,48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.000371Direct
    57903,47370,63748
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 63748 - Tudor/PWWP/MBT
  • 0.004766Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.3039Inherited
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01157Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4608Inherited
    48065,50729,50044
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.005502Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
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