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Biological Process (BP): negative regulation of developmental process

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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   biological_process [GO:0008150] <24>
+ + + 3:   biological regulation [GO:0065007] <5>(165|190) (757|933|542)
+ + 2:   regulation of biological process [GO:0050789] <34>(155|176) (709|883|505)
+ 1:   negative regulation of biological process [GO:0048519] <52>(72|76) (445|449|253)
+ 1:   regulation of developmental process [GO:0050793] <28>(34|33) (298|322|199)
0:   negative regulation of developmental process [GO:0051093] <84>(8|7) (150|118|68)
- 1:   negative regulation of cell differentiation [GO:0045596] <38>(7|6) (113|84|47)
- 1:   negative regulation of developmental growth [GO:0048640] <21>(1|1) (39|30|16)
- 1:   negative regulation of embryonic development [GO:0045992] <19>(0|0) (6|3|0)
- 1:   negative regulation of morphogenesis of an epithelium [GO:1905331] <15>(0|0) (6|5|2)
- 1:   negative regulation of post-embryonic development [GO:0048581] <14>(0|0) (13|5|2)
- 1:   negative regulation of nervous system development [GO:0051961] <13>(3|2) (74|60|35)
- 1:   negative regulation of spore-bearing organ development [GO:0075262] <11>(0|0) (0|0|0)
- 1:   negative regulation of kidney development [GO:0090185] <8>(0|0) (12|6|2)
- 1:   negative regulation of development of symbiont involved in interaction with host [GO:0044147] <7>(0|0) (0|0|0)
- 1:   negative regulation of tolerance induction [GO:0002644] <7>(0|0) (1|0|0)
- 1:   negative regulation of apoptotic process involved in development [GO:1904746] <6>(0|0) (5|1|0)
- 1:   negative regulation of vasculature development [GO:1901343] <6>(1|1) (28|25|20)
- 1:   negative regulation of hemopoiesis [GO:1903707] <5>(2|2) (35|23|19)
- 1:   negative regulation of isotype switching [GO:0045829] <4>(0|0) (3|1|1)
- 1:   negative regulation of Wnt signaling pathway involved in heart development [GO:0003308] <3>(0|0) (2|0|0)
- 1:   negative regulation of biomineral tissue development [GO:0070168] <3>(0|0) (10|11|9)
- 1:   negative regulation of bone development [GO:1903011] <3>(0|0) (1|2|1)
- 1:   negative regulation of cardiac chamber morphogenesis [GO:1901220] <3>(0|0) (0|0|0)
- 1:   negative regulation of cartilage development [GO:0061037] <3>(0|0) (5|1|0)
- 1:   negative regulation of cell aging [GO:0090344] <3>(0|0) (3|2|1)
- 1:   negative regulation of mesoderm development [GO:2000381] <3>(0|0) (1|1|0)
- 1:   negative regulation of sporulation [GO:0043939] <3>(0|0) (0|0|0)
- 1:   negative regulation of cardiac ventricle development [GO:1904413] <2>(0|0) (0|0|0)
- 1:   negative regulation of cell proliferation involved in heart morphogenesis [GO:2000137] <2>(0|0) (1|0|0)
- 1:   negative regulation of epidermis development [GO:0045683] <2>(1|1) (2|1|0)
- 1:   negative regulation of gonad development [GO:1905940] <2>(0|0) (2|2|1)
- 1:   negative regulation of muscle organ development [GO:0048635] <2>(0|0) (7|7|4)
- 1:   negative regulation of muscle tissue development [GO:1901862] <2>(0|0) (8|7|3)
- 1:   negative regulation of odontogenesis [GO:0042483] <2>(0|0) (0|0|0)
- 1:   negative regulation of salivary gland boundary specification [GO:0045705] <2>(0|0) (5|1|0)
- 1:   negative regulation of syncytium formation by plasma membrane fusion [GO:0034242] <2>(0|0) (0|0|0)
- 1:   negative regulation of blood microparticle formation [GO:2000333] <1>(0|0) (0|0|0)
- 1:   negative regulation of blood vessel remodeling [GO:0060313] <1>(0|0) (0|0|0)
- 1:   negative regulation of chitin-based cuticle tanning [GO:0045800] <1>(0|0) (0|0|0)
- 1:   negative regulation of cuticle pigmentation [GO:0048080] <1>(0|0) (0|0|0)
- 1:   negative regulation of ectoderm development [GO:2000384] <1>(0|0) (0|0|0)
- 1:   negative regulation of heart induction [GO:1901320] <1>(0|0) (0|0|0)
- 1:   negative regulation of leaf development [GO:1905622] <1>(0|0) (0|0|0)
- 1:   negative regulation of nodal signaling pathway involved in determination of left/right asymmetry [GO:1900146] <1>(0|0) (0|0|0)
- 1:   negative regulation of retina development in camera-type eye [GO:1902867] <1>(0|0) (2|1|0)
- 1:   negative regulation of spore germination [GO:1904360] <1>(0|0) (0|0|0)
- 1:   negative regulation of stem cell population maintenance [GO:1902455] <1>(0|0) (1|0|0)
- 1:   negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis [GO:2000057](0|0) (0|0|0)
- 1:   negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000054](0|0) (0|0|0)
- 1:   negative regulation of adipose tissue development [GO:1904178](0|0) (1|0|0)
- 1:   negative regulation of age-related resistance [GO:1904249](0|0) (0|0|0)
- 1:   negative regulation of aggregation involved in sorocarp development [GO:0110014](0|0) (0|0|0)
- 1:   negative regulation of anterior head development [GO:2000743](0|0) (0|0|0)
- 1:   negative regulation of apical ectodermal ridge formation [GO:1905141](0|0) (0|0|0)
- 1:   negative regulation of bone trabecula formation [GO:1900155](0|0) (0|0|0)
- 1:   negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior p [GO:0060829](0|0) (0|0|0)
- 1:   negative regulation of cell proliferation involved in compound eye morphogenesis [GO:2000496](0|0) (0|0|0)
- 1:   negative regulation of determination of dorsal identity [GO:2000016](0|0) (0|0|0)
- 1:   negative regulation of eclosion [GO:0045804](0|0) (0|0|0)
- 1:   negative regulation of epithelial cell proliferation involved in lung morphogenesis [GO:2000795](0|0) (0|0|0)
- 1:   negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770](0|0) (1|0|0)
- 1:   negative regulation of female pigmentation [GO:0048090](0|0) (0|0|0)
- 1:   negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate [GO:2000314](0|0) (0|0|0)
- 1:   negative regulation of germinal center formation [GO:0002635](0|0) (0|0|0)
- 1:   negative regulation of hepatocyte proliferation [GO:2000346](0|0) (0|1|1)
- 1:   negative regulation of insulin receptor signaling pathway involved in determination of adult lifespa [GO:1903105](0|0) (0|0|0)
- 1:   negative regulation of lactation [GO:1903488](0|0) (1|0|0)
- 1:   negative regulation of lamellipodium morphogenesis [GO:2000393](0|0) (0|0|0)
- 1:   negative regulation of lens epithelial cell proliferation [GO:2001110](0|0) (0|0|0)
- 1:   negative regulation of lung alveolus development [GO:1904654](0|0) (0|0|0)
- 1:   negative regulation of male pigmentation [GO:0048092](0|0) (0|0|0)
- 1:   negative regulation of mammary gland development in males by androgen receptor signaling pathway [GO:0060614](0|0) (0|0|0)
- 1:   negative regulation of mammary gland epithelial cell proliferation [GO:0033600](0|0) (0|0|0)
- 1:   negative regulation of mammary gland involution [GO:1903520](0|0) (0|0|0)
- 1:   negative regulation of mammary stem cell proliferation [GO:2000102](0|0) (0|0|0)
- 1:   negative regulation of mesenchymal cell proliferation involved in lung development [GO:2000791](0|0) (0|0|0)
- 1:   negative regulation of mesenchymal cell proliferation involved in ureter development [GO:0072200](0|0) (1|0|0)
- 1:   negative regulation of mitochondrial fission [GO:0090258](0|0) (0|0|0)
- 1:   negative regulation of mitochondrial fusion [GO:0010637](0|0) (2|1|0)
- 1:   negative regulation of nematode male tail tip morphogenesis [GO:0110038](0|0) (0|0|0)
- 1:   negative regulation of pharynx morphogenesis [GO:0110042](0|0) (0|0|0)
- 1:   negative regulation of plant organ morphogenesis [GO:1905422](0|0) (0|0|0)
- 1:   negative regulation of sclerotium development [GO:1901923](0|0) (0|0|0)
- 1:   negative regulation of shoot apical meristem development [GO:1902184](0|0) (0|0|0)
- 1:   negative regulation of synaptic vesicle lumen acidification [GO:1901547](0|0) (0|0|0)
- 1:   negative regulation of thyroid gland epithelial cell proliferation [GO:1904442](0|0) (0|0|0)
- 1:   negative regulation of trophoblast cell migration [GO:1901164](0|0) (0|0|0)
- 1:   negative regulation of tube lumen cavitation [GO:1903133](0|0) (0|0|0)
- 1:   negative regulation of vascular smooth muscle cell dedifferentiation [GO:1905175](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Annexin0.000000043880.00003341Direct
HLH, helix-loop-helix DNA-binding domain0.0000015230.000000000000003734Direct
Immunoglobulin0.00000000058160.00003732Direct
Interleukin 8-like chemokines0.0000000000081920.0000002433Direct
Family A G protein-coupled receptor-like0.19360.7656Inherited
Metallothionein0.075640.4835Inherited
C-type lectin-like0.000091150.06587Inherited
Serpins0.48651Inherited


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Annexin0.000000044670.00004668Direct
HLH, helix-loop-helix DNA-binding domain0.0000015360.00000000000008083Direct
Interleukin 8-like chemokines0.0000000000098510.0000006016Direct
Rhodopsin-like0.19590.9534Inherited
Metallothionein0.075430.5156Inherited
C-type lectin domain0.000086860.5495Inherited
Serpins0.47481Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this GO term
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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Cystine-knot cytokines0Direct
Kringle-like0Direct
Growth factor receptor domain0Direct
Hairpin loop containing domain-like0Direct
EGF/Laminin0Direct
Concanavalin A-like lectins/glucanases0Direct
HLH, helix-loop-helix DNA-binding domain0.000000000000001898Direct
STAT0.0000000001677Direct
Transcription factor STAT-4 N-domain0.0000000003884Direct
p53-like transcription factors0.0000000004425Direct
TSP-1 type 1 repeat0.000000001108Direct
HR1 repeat0.000000003139Direct
TSP type-3 repeat0.00000001316Direct
CCCH zinc finger0.00000001475Direct
Thyroglobulin type-1 domain0.00000003009Direct
Notch domain0.00000004592Direct
FAT domain of focal adhesion kinase0.00000007041Direct
Interleukin 8-like chemokines0.0000001526Direct
Alkaline phosphatase-like0.0000005367Direct
SRCR-like0.0000007413Direct
tRNA-binding arm0.000002458Direct
SMAD MH1 domain0.00000374Direct
Trypsin-like serine proteases0.000006635Direct
Composite domain of metallo-dependent hydrolases0.00001549Direct
Annexin0.00002247Direct
Immunoglobulin0.00002512Direct
GLA-domain0.00003774Direct
Orange domain-like0.00005757Direct
Cystatin/monellin0.0001152Direct
Plexin repeat0.0001221Direct
LDL receptor-like module0.0001383Direct
Galactose-binding domain-like0.0001565Direct
RUN domain-like0.0001741Direct
(Phosphotyrosine protein) phosphatases II0.0002704Direct
FnI-like domain0.0003196Direct
SAM/Pointed domain0.0003522Direct
TAFH domain-like0.0003818Direct
TNF-like0.0004882Direct
Sema domain0.0005034Direct
YWTD domain0.0006444Direct
SH2 domain0.0008438Direct
Fibronectin type III0.0008659Direct
Actin-like ATPase domain1Inherited
ENTH/VHS domain0.006098Inherited
Cytokine0.1332Inherited
Hedgehog/intein (Hint) domain0.01Inherited
Hedgehog/DD-peptidase0.01Inherited
Frizzled cysteine-rich domain0.1103Inherited
TIMP-like0.1119Inherited
Inhibitor of apoptosis (IAP) repeat0.657Inherited
UBC-like0.3472Inherited
WD40 repeat-like1Inherited
DHS-like NAD/FAD-binding domain0.04645Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.009725Inherited
"Winged helix" DNA-binding domain0.1121Inherited
Periplasmic binding protein-like II0.9661Inherited
A DNA-binding domain in eukaryotic transcription factors0.1052Inherited
GAS2 domain-like0.05327Inherited
Calponin-homology domain, CH-domain0.6312Inherited
SPOC domain-like0.003284Inherited
PDZ domain-like1Inherited
Cyclin-like0.8727Inherited
Family A G protein-coupled receptor-like0.6708Inherited
Ankyrin repeat0.06005Inherited
Class II aaRS and biotin synthetases0.2587Inherited
lambda repressor-like DNA-binding domains1Inherited
RCC1/BLIP-II0.02218Inherited
VHP, Villin headpiece domain0.3075Inherited
Bet v1-like0.1385Inherited
beta-beta-alpha zinc fingers0.567Inherited
Homeodomain-like0.00481Inherited
E2F-DP heterodimerization region0.01901Inherited
N-terminal domain of cbl (N-cbl)0.08223Inherited
Chromo domain-like1Inherited
Metalloproteases ("zincins"), catalytic domain0.9503Inherited
alpha/beta-Hydrolases1Inherited
DBL homology domain (DH-domain)0.006951Inherited
Cupredoxins0.2693Inherited
F-box domain0.07362Inherited
BAR/IMD domain-like0.002661Inherited
SH3-domain0.9726Inherited
Second domain of FERM0.01143Inherited
CRAL/TRIO domain0.00919Inherited
Rap/Ran-GAP0.0172Inherited
ARM repeat1Inherited
Acetyl-CoA synthetase-like1Inherited
GTPase activation domain, GAP0.07465Inherited
RNA-binding domain, RBD1Inherited
HMG-box0.03535Inherited
Quinoprotein alcohol dehydrogenase-like0.5749Inherited
FAD/NAD(P)-binding domain1Inherited
HIT/MYND zinc finger-like0.03019Inherited
Fibrinogen C-terminal domain-like0.001907Inherited
Soluble quinoprotein glucose dehydrogenase0.007534Inherited
SRF-like0.3562Inherited
JAB1/MPN domain0.4219Inherited
Subtilisin-like0.623Inherited
Insulin-like0.6839Inherited
DNA-binding domain0.842Inherited
SET domain1Inherited
Histone-fold1Inherited
POZ domain1Inherited
WW domain0.7061Inherited
vWA-like1Inherited
SOCS box-like0.01425Inherited
Snake toxin-like1Inherited
TB module/8-cys domain0.02775Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.7037Inherited
Clavaminate synthase-like0.5938Inherited
Pseudo ankyrin repeat-like0.01089Inherited
DNase I-like0.5411Inherited
SAND domain-like0.9855Inherited
Putative DNA-binding domain1Inherited
Arginase/deacetylase0.001082Inherited
Metallo-dependent hydrolases0.02479Inherited
Carbonic anhydrase0.04477Inherited
FKBP-like0.2771Inherited
MHC antigen-recognition domain0.2528Inherited
EF-hand0.9444Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
HCP-like0.5809Inherited
PH domain-like0.1747Inherited
Protein kinase-like (PK-like)1Inherited
N-acetylmuramoyl-L-alanine amidase-like0.0408Inherited
Kazal-type serine protease inhibitors0.001251Inherited
Metallothionein0.4103Inherited
DNA-binding protein LAG-1 (CSL)0.001819Inherited
PR-1-like0.159Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2082Inherited
Multidrug efflux transporter AcrB transmembrane domain0.001364Inherited
Nucleotide cyclase0.07641Inherited
SMAD/FHA domain0.08331Inherited
C-type lectin-like0.05152Inherited
E set domains0.9725Inherited
Serum albumin-like0.234Inherited
Serpins0.989Inherited
DEATH domain1Inherited
PYP-like sensor domain (PAS domain)0.2862Inherited
Ras GEF0.3796Inherited
cAMP-binding domain-like0.5863Inherited
L domain-like0.01286Inherited
Nuclear receptor ligand-binding domain0.5211Inherited
Integrin domains0.08618Inherited
Ubiquitin-like0.7547Inherited
RING/U-box0.7896Inherited
RNase III domain-like0.9012Inherited
dsRNA-binding domain-like1Inherited
CCHHC domain0.01991Inherited
Acyl-CoA N-acyltransferases (Nat)1Inherited
BRCT domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    81383,49899
  • 81383 - F-box domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    82895,57196
  • 82895 - TSP-1 type 1 repeat
  • 57196 - EGF/Laminin
  • 0.00000000000005144Direct
    53649,53649
  • 53649 - Alkaline phosphatase-like
  • 53649 - Alkaline phosphatase-like
  • 0.000000000001502Direct
    49899,48726
  • 49899 - Concanavalin A-like lectins/glucanases
  • 48726 - Immunoglobulin
  • 0.000000000002194Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.000000000003407Direct
    56487,50494
  • 56487 - SRCR-like
  • 50494 - Trypsin-like serine proteases
  • 0.00000000002857Direct
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.00000000008439Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0000000001677Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0000000002935Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0000000003884Direct
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000000004284Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.0000000005167Direct
    100895,47473
  • 100895 - Kazal-type serine protease inhibitors
  • 47473 - EF-hand
  • 0.000000003139Direct
    48403,47031
  • 48403 - Ankyrin repeat
  • 47031 - Second domain of FERM
  • 0.000000006834Direct
    103647,49899
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00000001316Direct
    103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.00000001316Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0.00000001359Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00000001401Direct
    47473,57610
  • 47473 - EF-hand
  • 57610 - Thyroglobulin type-1 domain
  • 0.00000001883Direct
    53850,53850
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 0.0000000216Direct
    52058,57196
  • 52058 - L domain-like
  • 57196 - EGF/Laminin
  • 0.00000002168Direct
    48350,50044
  • 48350 - GTPase activation domain, GAP
  • 50044 - SH3-domain
  • 0.00000003073Direct
    52799,52799
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.00000003959Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.00000006129Direct
    49265,56496
  • 49265 - Fibronectin type III
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.00000007041Direct
    48371,48350
  • 48371 - ARM repeat
  • 48350 - GTPase activation domain, GAP
  • 0.00000008451Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.00000009728Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0000002286Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0.0000002377Direct
    56112,50998
  • 56112 - Protein kinase-like (PK-like)
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 0.0000003217Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0000006177Direct
    48726,82895
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 0.0000006527Direct
    54001,144232
  • 54001 - Cysteine proteinases
  • 144232 - HIT/MYND zinc finger-like
  • 0.000001444Direct
    48726,57196
  • 48726 - Immunoglobulin
  • 57196 - EGF/Laminin
  • 0.00000186Direct
    54403,54403
  • 54403 - Cystatin/monellin
  • 54403 - Cystatin/monellin
  • 0.000003532Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.000003739Direct
    57630,57184
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 0.000003766Direct
    49723,140741
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 140741 - RUN domain-like
  • 0.000004005Direct
    140741,49723
  • 140741 - RUN domain-like
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.000008754Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.00001462Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0000147Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0.00002404Direct
    47576,143575
  • 47576 - Calponin-homology domain, CH-domain
  • 143575 - GAS2 domain-like
  • 0.00002626Direct
    103575,82895
  • 103575 - Plexin repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000283Direct
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.00002974Direct
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00003122Direct
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.00005757Direct
    55961,55961
  • 55961 - Bet v1-like
  • 55961 - Bet v1-like
  • 0.0001185Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.0001615Direct
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.0001615Direct
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.0002928Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.0003251Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.0003266Direct
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.0004003Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0006734Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 1Inherited
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.01Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.006745Inherited
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0.02023Inherited
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.009496Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.0511Inherited
    48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0.0161Inherited
    56487,56487
  • 56487 - SRCR-like
  • 56487 - SRCR-like
  • 0.1111Inherited
    81901,48452
  • 81901 - HCP-like
  • 48452 - TPR-like
  • 0.00822Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.8577Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.5415Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.3197Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1492Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.1662Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.01901Inherited
    55550,57850
  • 55550 - SH2 domain
  • 57850 - RING/U-box
  • 0.08223Inherited
    47668,47473
  • 47668 - N-terminal domain of cbl (N-cbl)
  • 47473 - EF-hand
  • 0.08223Inherited
    47473,55550
  • 47473 - EF-hand
  • 55550 - SH2 domain
  • 0.08223Inherited
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0.1814Inherited
    50729,50044
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.07124Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.004262Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.04193Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.1866Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.2435Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.01502Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.9602Inherited
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.0408Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 1Inherited
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.03694Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2846Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.5404Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.06312Inherited
    49854,49854
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0.2703Inherited
    52821,52799
  • 52821 - Rhodanese/Cell cycle control phosphatase
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.6564Inherited
    63748,63748
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 0.1976Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.7093Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.007249Inherited
    46955,63763
  • 46955 - Putative DNA-binding domain
  • 63763 - SAND domain-like
  • 0.8586Inherited
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0.09526Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.219Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5416Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.004588Inherited
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.02408Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.2397Inherited
    54534,48452
  • 54534 - FKBP-like
  • 48452 - TPR-like
  • 0.009503Inherited
    51069,49265
  • 51069 - Carbonic anhydrase
  • 49265 - Fibronectin type III
  • 0.001819Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.001658Inherited
    49417,110217
  • 49417 - p53-like transcription factors
  • 110217 - DNA-binding protein LAG-1 (CSL)
  • 0.001819Inherited
    110217,81296
  • 110217 - DNA-binding protein LAG-1 (CSL)
  • 81296 - E set domains
  • 0.001819Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.2034Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.234Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.008134Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.4876Inherited
    54236,48366
  • 54236 - Ubiquitin-like
  • 48366 - Ras GEF
  • 0.001719Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.8984Inherited
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.04786Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.02023Inherited
    69065,54768
  • 69065 - RNase III domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.5334Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57630,57196,57184
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    82895,82895,57196
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 57196 - EGF/Laminin
  • 0.00000000000005144Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0000000000005748Direct
    57603,82895,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000000000005941Direct
    51338,51556,51338
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0.000000000001089Direct
    49899,48726,49265
  • 49899 - Concanavalin A-like lectins/glucanases
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.000000000002194Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000000009401Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0000000003884Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.000000001957Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.000000003139Direct
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.000000003689Direct
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.000000007146Direct
    103647,103647,49899
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00000001316Direct
    103647,103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.00000001316Direct
    90193,90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.00000001883Direct
    52058,57196,57196
  • 52058 - L domain-like
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00000002168Direct
    57196,57184,49899
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00000004592Direct
    57184,49899,57196
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.0000001117Direct
    100895,47473,57610
  • 100895 - Kazal-type serine protease inhibitors
  • 47473 - EF-hand
  • 57610 - Thyroglobulin type-1 domain
  • 0.0000001117Direct
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000002238Direct
    48726,48726,82895
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 0.0000006527Direct
    48726,82895,82895
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000006527Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0000008283Direct
    57630,57184,57196
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.000001444Direct
    49265,49265,56496
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.000002859Direct
    54534,54534,48452
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 48452 - TPR-like
  • 0.000003509Direct
    52058,52058,57196
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 57196 - EGF/Laminin
  • 0.000004005Direct
    140741,49723,140741
  • 140741 - RUN domain-like
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 140741 - RUN domain-like
  • 0.000004005Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.000005324Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.00001462Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.00002467Direct
    101912,103575,82895
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000283Direct
    103575,82895,82895
  • 103575 - Plexin repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000283Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00003611Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00005463Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.0001099Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.0001181Direct
    57630,57184,49899
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0001361Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.0002252Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.0004003Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0004611Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0004743Direct
    48452,81901,48452
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 48452 - TPR-like
  • 0.000845Direct
    57184,57196,49899
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000845Direct
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.3693Inherited
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.009268Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.04206Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.06044Inherited
    56487,56487,56487
  • 56487 - SRCR-like
  • 56487 - SRCR-like
  • 56487 - SRCR-like
  • 0.07124Inherited
    81901,48452,48452
  • 81901 - HCP-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.003345Inherited
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.004947Inherited
    47668,47473,55550
  • 47668 - N-terminal domain of cbl (N-cbl)
  • 47473 - EF-hand
  • 55550 - SH2 domain
  • 0.08223Inherited
    47473,55550,57850
  • 47473 - EF-hand
  • 55550 - SH2 domain
  • 57850 - RING/U-box
  • 0.08223Inherited
    48065,50729,50044
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.0408Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.01788Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.6216Inherited
    57196,57196,49899
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.02023Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.09971Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 1Inherited
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0172Inherited
    63748,63748,63748
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 0.1073Inherited
    49562,49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.001107Inherited
    49417,110217,81296
  • 49417 - p53-like transcription factors
  • 110217 - DNA-binding protein LAG-1 (CSL)
  • 81296 - E set domains
  • 0.001819Inherited
    47031,50729,56112
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0161Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
    Plot tree as:   Download Newick format tree:   Browsing in Tree_gateway:
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