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Biological Process (BP): regulation of hydrolase activity

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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   biological_process [GO:0008150] <24>
+ + + 3:   biological regulation [GO:0065007] <5>(165|190) (757|933|542)
+ + 2:   regulation of molecular function [GO:0065009] <12>(42|40) (274|255|136)
+ 1:   regulation of catalytic activity [GO:0050790] <11>(31|29) (223|194|106)
0:   regulation of hydrolase activity [GO:0051336] <24>(18|18) (150|113|52)
- 1:   positive regulation of hydrolase activity [GO:0051345] <23>(8|8) (86|65|30)
- 1:   negative regulation of hydrolase activity [GO:0051346] <19>(7|7) (56|28|16)
- 1:   regulation of ATPase activity [GO:0043462] <16>(2|2) (13|4|2)
- 1:   regulation of peptidase activity [GO:0052547] <9>(10|11) (48|39|20)
- 1:   regulation of phosphatase activity [GO:0010921] <9>(1|2) (21|14|8)
- 1:   regulation of nuclease activity [GO:0032069] <5>(0|0) (7|2|0)
- 1:   regulation of GTPase activity [GO:0043087] <4>(3|1) (45|44|21)
- 1:   regulation of helicase activity [GO:0051095] <4>(0|0) (3|1|0)
- 1:   regulation of lipase activity [GO:0060191] <4>(2|2) (24|14|5)
- 1:   regulation of microtubule motor activity [GO:2000574] <4>(0|0) (1|0|0)
- 1:   regulation of DNA N-glycosylase activity [GO:1902544] <3>(0|0) (0|0|0)
- 1:   regulation of exo-alpha-sialidase activity [GO:1903015] <3>(0|0) (0|0|0)
- 1:   regulation of microfilament motor activity [GO:0120079] <3>(0|0) (0|0|0)
- 1:   regulation of GTP cyclohydrolase I activity [GO:0043095] <2>(0|0) (0|0|0)
- 1:   regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051342] <2>(0|0) (1|1|0)
- 1:   regulation of dUTP diphosphatase activity [GO:1903627] <2>(0|0) (0|0|0)
- 1:   regulation of endo-1,4-beta-xylanase activity [GO:0051421] <2>(0|0) (0|0|0)
- 1:   regulation of glucosylceramidase activity [GO:1905123] <2>(0|0) (0|0|0)
- 1:   regulation of histone deacetylase activity [GO:1901725] <2>(0|0) (1|0|0)
- 1:   regulation of lysozyme activity [GO:1903590] <2>(0|0) (0|0|0)
- 1:   regulation of beta-lactamase activity [GO:0033252] <1>(0|0) (1|0|0)
- 1:   regulation of m7G(5')pppN diphosphatase activity [GO:1903398] <1>(0|0) (0|0|0)
- 1:   regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands [GO:1903021] <1>(0|0) (0|0|0)
- 1:   regulation of urease activity [GO:1905181] <1>(0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Bcl-2 inhibitors of programmed cell death0.000000014380.000000000001954Direct
Cystatin/monellin0.00000033530.0000002043Direct
Inhibitor of apoptosis (IAP) repeat0.0000000000019390.000008337Direct
Kazal-type serine protease inhibitors0.000043270Direct
Metallo-dependent hydrolases00.000003752Direct
Metallothionein0.000000081530.000002077Direct
RNase A-like00Direct
Serpins0.000017070.00002209Direct
Caspase-like0.055630.0000001209Inherited
EF-hand0.30491Inherited
TIMP-like0.00089410.001445Inherited
4-helical cytokines10.7679Inherited
Calcium-dependent phosphotriesterase0.00000000052640.008525Inherited
Regulator of G-protein signaling, RGS0.0071250.00023Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.0000000050730.3007Inherited
Phosphoglycerate mutase-like0.17610.4477Inherited
P-loop containing nucleoside triphosphate hydrolases0.64441Inherited
Casein kinase II beta subunit0.0000000000002240.002935Inherited


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Family

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Bcl-2 inhibitors of programmed cell death0.0000000044690.000000000001178Direct
Cystatins0.0000087910.00002612Direct
Inhibitor of apoptosis (IAP) repeat0.0000000000040720.000005944Direct
Metallothionein0.00000018820.000005294Direct
Ovomucoid domain III-like0.000015630.0000000000000509Direct
Papain-like0.000000000020180.0000002319Direct
Renal dipeptidase00Direct
Ribonuclease A-like00Direct
Serpins0.0000072690.00001559Direct
SGL-like0.0000000000017460.0000000001698Direct
Tissue inhibitor of metalloproteinases, TIMP0.00052840.0001853Direct
S100 proteins0.0027450.001251Inherited
Caspase catalytic domain0.042270.000000005991Inherited
G proteins0.53860.1004Inherited
Long-chain cytokines10.4793Inherited
Regulator of G-protein signaling, RGS0.0047430.0001613Inherited
Casein kinase II beta subunit0.00000000000052160.002359Inherited
Calmodulin-like0.89850.5507Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this GO term
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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
F1 ATPase inhibitor, IF1, C-terminal domain0Direct
RNase A-like0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Kazal-type serine protease inhibitors0Direct
Plant inhibitors of proteinases and amylases0Direct
Transcription factor STAT-4 N-domain0.0000000000000387Direct
STAT0.000000000000169Direct
Bcl-2 inhibitors of programmed cell death0.000000000001075Direct
GTPase activation domain, GAP0.000000000002633Direct
Troponin coil-coiled subunits0.000000001675Direct
DEATH domain0.00000004145Direct
Bowman-Birk inhibitor, BBI0.00000004182Direct
Caspase-like0.00000007525Direct
Cystatin/monellin0.0000001278Direct
DBL homology domain (DH-domain)0.0000003904Direct
Smac/diablo0.000000422Direct
Galactose-binding domain-like0.0000005603Direct
Metallothionein0.000001341Direct
PAP/OAS1 substrate-binding domain0.000001449Direct
Hedgehog/DD-peptidase0.000002094Direct
Metallo-dependent hydrolases0.000002442Direct
PH domain-like0.000004079Direct
HIN-2000 domain-like0.000004115Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0.000004806Direct
Inhibitor of apoptosis (IAP) repeat0.0000055Direct
p53-like transcription factors0.00001007Direct
Hedgehog/intein (Hint) domain0.00001163Direct
Serpins0.00001476Direct
VPS9 domain0.00001589Direct
PTPA-like0.00001818Direct
Ras GEF0.00002617Direct
Stathmin0.00004475Direct
Zn-finger domain of Sec23/240.00005496Direct
WW domain0.00005574Direct
PDZ domain-like0.00006522Direct
SH3-domain0.00008976Direct
Rap/Ran-GAP0.00009783Direct
Helical domain of Sec23/240.00009784Direct
Regulator of G-protein signaling, RGS0.0001594Direct
BAR/IMD domain-like0.0002506Direct
Interleukin 8-like chemokines0.0003892Direct
CSL zinc finger0.0004035Direct
TNF receptor-like0.000643Direct
Fic-like0.0006666Direct
IP3 receptor type 1 binding core, domain 20.0007378Direct
SAM/Pointed domain0.01075Inherited
ARM repeat0.1454Inherited
Fibronectin type III0.003045Inherited
WD40 repeat-like1Inherited
Class I glutamine amidotransferase-like0.7329Inherited
ENTH/VHS domain0.1605Inherited
GAT-like domain0.09333Inherited
Complement control module/SCR domain0.09307Inherited
Leucine zipper domain0.9745Inherited
Casein kinase II beta subunit0.002133Inherited
Bet v1-like0.3474Inherited
Fibrinogen C-terminal domain-like0.6119Inherited
Apolipoprotein A-I0.004015Inherited
Subtilisin-like0.2469Inherited
Protease propeptides/inhibitors0.2479Inherited
PLC-like phosphodiesterases0.75Inherited
Family A G protein-coupled receptor-like1Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.1422Inherited
RING/U-box1Inherited
EF-hand1Inherited
Concanavalin A-like lectins/glucanases0.1173Inherited
Oligoxyloglucan reducing end-specific cellobiohydrolase0.009348Inherited
Nitric oxide (NO) synthase oxygenase domain0.253Inherited
Flavoproteins0.359Inherited
"Winged helix" DNA-binding domain0.04002Inherited
C-terminal, gelsolin-like domain of Sec23/240.001899Inherited
ArfGap/RecO-like zinc finger0.002133Inherited
SEA domain0.00259Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.003014Inherited
FF domain0.003472Inherited
Transducin (alpha subunit), insertion domain0.02588Inherited
Nucleic acid-binding proteins0.5107Inherited
DNA repair protein MutS, domain III0.02037Inherited
BRCT domain0.305Inherited
Phosphoglycerate mutase-like0.3784Inherited
Ubiquitin-like1Inherited
beta-sandwich domain of Sec23/240.002334Inherited
PX domain0.05898Inherited
dsRNA-binding domain-like0.9295Inherited
4-helical cytokines0.6729Inherited
Insulin-like0.3942Inherited
Calcium-dependent phosphotriesterase0.006305Inherited
Chaperone J-domain0.154Inherited
Tropomyosin0.257Inherited
Cytokine1Inherited
Cyclophilin-like0.2066Inherited
Bromodomain0.5843Inherited
HLH, helix-loop-helix DNA-binding domain0.01127Inherited
PP2C-like0.6826Inherited
SH2 domain0.08332Inherited
Succinyl-CoA synthetase domains0.0157Inherited
RNI-like0.05844Inherited
Growth factor receptor domain0.006466Inherited
SAP domain0.003599Inherited
GLA-domain0.001133Inherited
FAD-binding/transporter-associated domain-like0.4253Inherited
Transducin (heterotrimeric G protein), gamma chain0.007527Inherited
RUN domain-like0.02657Inherited
cAMP-binding domain-like0.04664Inherited
Calponin-homology domain, CH-domain0.06159Inherited
NAD kinase/diacylglycerol kinase-like0.09755Inherited
L domain-like1Inherited
Ankyrin repeat1Inherited
Sec7 domain0.01912Inherited
RCC1/BLIP-II0.02006Inherited
Sema domain0.1879Inherited
Plexin repeat0.203Inherited
Supernatant protein factor (SPF), C-terminal domain0.01065Inherited
E set domains0.8797Inherited
N-acetylmuramoyl-L-alanine amidase-like0.01756Inherited
vWA-like0.07411Inherited
Protein kinase-like (PK-like)1Inherited
PapD-like0.007981Inherited
DNA clamp0.1311Inherited
Quinoprotein alcohol dehydrogenase-like0.05479Inherited
Nucleoplasmin-like core domain0.01417Inherited
Trypsin-like serine proteases1Inherited
Nucleotidyltransferase0.00252Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Prefoldin0.1179Inherited
Cadherin-like0.4899Inherited
RNA-binding domain, RBD1Inherited
Integrin alpha N-terminal domain0.001148Inherited
Integrin domains0.1623Inherited
SRF-like0.1056Inherited
Nuclear receptor ligand-binding domain0.05889Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1632Inherited
MIR domain0.01273Inherited
Hormone receptor domain1Inherited
Cystine-knot cytokines1Inherited
SMAD/FHA domain0.6112Inherited
Immunoglobulin0.7086Inherited
EGF/Laminin1Inherited
Thyroglobulin type-1 domain0.002036Inherited
Elafin-like0.001785Inherited
Serum albumin-like0.003799Inherited
BPTI-like0.7198Inherited
TIMP-like0.001036Inherited
FYVE/PHD zinc finger0.02595Inherited
YWTD domain0.7273Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.249Inherited
Cysteine-rich domain0.1059Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.1229Inherited
TNF-like1Inherited
Homeodomain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    54236,48366
  • 54236 - Ubiquitin-like
  • 48366 - Ras GEF
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    50729,82185
  • 50729 - PH domain-like
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    50985,48065
  • 50985 - RCC1/BLIP-II
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47473,57610
  • 47473 - EF-hand
  • 57610 - Thyroglobulin type-1 domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.00000000000003185Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0000000000000573Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000000000006907Direct
    100895,47473
  • 100895 - Kazal-type serine protease inhibitors
  • 47473 - EF-hand
  • 0.0000000000001972Direct
    50729,50044
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.0000000000002093Direct
    68906,57850
  • 68906 - SAP domain
  • 57850 - RING/U-box
  • 0.000000000001218Direct
    100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.000000000007018Direct
    57630,57184
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 0.00000000004343Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0.00000000005373Direct
    50044,48065
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.0000000003077Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.0000000003077Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0.000000002574Direct
    48670,48097
  • 48670 - Transducin (heterotrimeric G protein), gamma chain
  • 48097 - Regulator of G-protein signaling, RGS
  • 0.00000001139Direct
    56112,54236
  • 56112 - Protein kinase-like (PK-like)
  • 54236 - Ubiquitin-like
  • 0.0000000129Direct
    57256,57362
  • 57256 - Elafin-like
  • 57362 - BPTI-like
  • 0.00000004182Direct
    47473,57889
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0.0000001016Direct
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.0000001056Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.0000001423Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0.0000005105Direct
    48371,111347
  • 48371 - ARM repeat
  • 111347 - Rap/Ran-GAP
  • 0.0000006263Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.00000096Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0.000001029Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000001352Direct
    50729,48350
  • 50729 - PH domain-like
  • 48350 - GTPase activation domain, GAP
  • 0.000001571Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000001805Direct
    159141,159141
  • 159141 - HIN-2000 domain-like
  • 159141 - HIN-2000 domain-like
  • 0.00000284Direct
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0.000003567Direct
    48350,54236
  • 48350 - GTPase activation domain, GAP
  • 54236 - Ubiquitin-like
  • 0.000003826Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0.00000502Direct
    57924,52540
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000007267Direct
    47923,52821
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 52821 - Rhodanese/Cell cycle control phosphatase
  • 0.000007267Direct
    46785,51206
  • 46785 - "Winged helix" DNA-binding domain
  • 51206 - cAMP-binding domain-like
  • 0.000007267Direct
    46565,144217
  • 46565 - Chaperone J-domain
  • 144217 - CSL zinc finger
  • 0.000007267Direct
    48350,50044
  • 48350 - GTPase activation domain, GAP
  • 50044 - SH3-domain
  • 0.00000794Direct
    54403,54403
  • 54403 - Cystatin/monellin
  • 54403 - Cystatin/monellin
  • 0.00001549Direct
    50729,49562
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.00001818Direct
    46565,52833
  • 46565 - Chaperone J-domain
  • 52833 - Thioredoxin-like
  • 0.0000435Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0.00005496Direct
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00005574Direct
    82185,82185
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0.00006841Direct
    57196,100895
  • 57196 - EGF/Laminin
  • 100895 - Kazal-type serine protease inhibitors
  • 0.00008218Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.00009784Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.0002646Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0003587Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.0005394Direct
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.000643Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000643Direct
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.003599Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.9856Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.09333Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1311Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.5379Inherited
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.01847Inherited
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0.1032Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.1582Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.2061Inherited
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.04268Inherited
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.4754Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.3287Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1684Inherited
    56512,52218
  • 56512 - Nitric oxide (NO) synthase oxygenase domain
  • 52218 - Flavoproteins
  • 0.253Inherited
    55550,50729
  • 55550 - SH2 domain
  • 50729 - PH domain-like
  • 0.003472Inherited
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0.01417Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.01912Inherited
    103657,50729
  • 103657 - BAR/IMD domain-like
  • 50729 - PH domain-like
  • 0.02657Inherited
    50729,57863
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 0.09333Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.253Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02588Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01941Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.0256Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.2678Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.004914Inherited
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0.002411Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01102Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.6189Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.2251Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.002583Inherited
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.01417Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.05472Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.09094Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.1247Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.793Inherited
    51045,50156
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0.001133Inherited
    52540,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.002133Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.01312Inherited
    50156,52540
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.09333Inherited
    55979,55979
  • 55979 - DNA clamp
  • 55979 - DNA clamp
  • 0.1311Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.9346Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4754Inherited
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.007527Inherited
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0.007527Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.06107Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.4448Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.5254Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.05596Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.09406Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.1558Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.07237Inherited
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 1Inherited
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.04712Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4099Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.06162Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.002879Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.003472Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.1204Inherited
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0.5379Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57630,57196,57184
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    48065,50729,82185
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0Direct
    50729,82185,82185
  • 50729 - PH domain-like
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0Direct
    50985,48065,50729
  • 50985 - RCC1/BLIP-II
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    100895,47473,57610
  • 100895 - Kazal-type serine protease inhibitors
  • 47473 - EF-hand
  • 57610 - Thyroglobulin type-1 domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00000000000001446Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00000000000003185Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.00000000000008894Direct
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.0000000000008335Direct
    48065,50729,50044
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.000000000008832Direct
    50044,48065,50729
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.0000000001514Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0000000001929Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0.000000002574Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.000000004112Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000000005109Direct
    57630,57184,49899
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00000004182Direct
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00000008378Direct
    57196,57196,100895
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 100895 - Kazal-type serine protease inhibitors
  • 0.0000001389Direct
    57184,57196,49899
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0000006263Direct
    57630,57184,57196
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0000006263Direct
    82919,53300,81995
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0.0000007936Direct
    50729,49562,48350
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.000001894Direct
    57924,57924,52540
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000003826Direct
    46565,52833,52833
  • 46565 - Chaperone J-domain
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.000003826Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.00000502Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0.00000502Direct
    51905,51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.0001786Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.0002318Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.005898Inherited
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.01417Inherited
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.006163Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.3004Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.006974Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.253Inherited
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.001399Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.136Inherited
    57196,57184,49899
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.001696Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.01216Inherited
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.01417Inherited
    55550,50044,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.02657Inherited
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.09333Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.3942Inherited
    51045,51045,50156
  • 51045 - WW domain
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0.001133Inherited
    52540,51045,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.002133Inherited
    50156,52540,51045
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.09333Inherited
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.007527Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.4465Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.09406Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.09406Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.1558Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9279Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4754Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
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