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Biological Process (BP): positive regulation of hydrolase activity

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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   biological_process [GO:0008150] <24>
+ + + + 4:   biological regulation [GO:0065007] <5>(165|190) (757|933|542)
+ + + 3:   regulation of molecular function [GO:0065009] <12>(42|40) (274|255|136)
+ + 2:   positive regulation of molecular function [GO:0044093] <11>(21|22) (167|154|83)
+ + 2:   regulation of catalytic activity [GO:0050790] <11>(31|29) (223|194|106)
+ 1:   positive regulation of catalytic activity [GO:0043085] <9>(17|16) (139|121|70)
+ 1:   regulation of hydrolase activity [GO:0051336] <24>(18|18) (150|113|52)
0:   positive regulation of hydrolase activity [GO:0051345] <23>(8|8) (86|65|30)
- 1:   positive regulation of ATPase activity [GO:0032781] <12>(2|2) (10|3|2)
- 1:   positive regulation of phosphatase activity [GO:0010922] <7>(0|0) (10|9|6)
- 1:   positive regulation of peptidase activity [GO:0010952] <5>(1|3) (23|16|7)
- 1:   positive regulation of nuclease activity [GO:0032075] <4>(0|0) (3|1|0)
- 1:   positive regulation of GTPase activity [GO:0043547] <2>(3|1) (30|28|12)
- 1:   positive regulation of lipase activity [GO:0060193] <2>(2|2) (14|6|3)
- 1:   positive regulation of microtubule motor activity [GO:2000576] <2>(0|0) (0|0|0)
- 1:   positive regulation of DNA N-glycosylase activity [GO:1902546] <1>(0|0) (0|0|0)
- 1:   positive regulation of deacetylase activity [GO:0090045] <1>(0|0) (2|0|0)
- 1:   positive regulation of helicase activity [GO:0051096] <1>(0|0) (2|1|0)
- 1:   positive regulation of microfilament motor activity [GO:0120081] <1>(0|0) (0|0|0)
- 1:   positive regulation of GTP cyclohydrolase I activity [GO:0043104](0|0) (0|0|0)
- 1:   positive regulation of Lys63-specific deubiquitinase activity [GO:1903007](0|0) (0|0|0)
- 1:   positive regulation of beta-galactosidase activity [GO:1903771](0|0) (0|0|0)
- 1:   positive regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051343](0|0) (0|0|0)
- 1:   positive regulation of dUTP diphosphatase activity [GO:1903629](0|0) (0|0|0)
- 1:   positive regulation of endo-1,4-beta-xylanase activity [GO:0051423](0|0) (0|0|0)
- 1:   positive regulation of exo-alpha-sialidase activity [GO:1903017](0|0) (0|0|0)
- 1:   positive regulation of glucosylceramidase activity [GO:1905125](0|0) (0|0|0)
- 1:   positive regulation of lysozyme activity [GO:1903592](0|0) (0|0|0)
- 1:   positive regulation of m7G(5')pppN diphosphatase activity [GO:1903399](0|0) (0|0|0)
- 1:   positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA stra [GO:1903022](0|0) (0|0|0)
- 1:   positive regulation of urease activity [GO:1905182](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Bcl-2 inhibitors of programmed cell death0.00000058570.00001445Direct
Calcium-dependent phosphotriesterase0.00000000000062240.0002631Direct
Regulator of G-protein signaling, RGS00.00000009482Direct
RNase A-like00Direct
4-helical cytokines0.97120.01552Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.000000000064950.007885Inherited
Phosphoglycerate mutase-like0.0068690.04991Inherited
P-loop containing nucleoside triphosphate hydrolases0.041370.5221Inherited


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Bcl-2 inhibitors of programmed cell death0.00000015240.00001554Direct
Papain-like0.00000036270.0000007462Direct
Regulator of G-protein signaling, RGS00.0000001045Direct
Ribonuclease A-like00Direct
S100 proteins0.0000091880.00003604Direct
SGL-like0.0000000000000011680.0000000000006621Direct
Long-chain cytokines0.94440.0091Inherited
G proteins0.013310.001878Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this GO term
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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
RNase A-like0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
GTPase activation domain, GAP0.000000000001072Direct
DBL homology domain (DH-domain)0.000000002871Direct
p53-like transcription factors0.00000001697Direct
Smac/diablo0.00000002987Direct
Hedgehog/DD-peptidase0.00000003671Direct
PH domain-like0.00000005201Direct
Regulator of G-protein signaling, RGS0.00000005883Direct
Ras GEF0.00000007597Direct
Rap/Ran-GAP0.0000001048Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0.0000002174Direct
Hedgehog/intein (Hint) domain0.0000002204Direct
PDZ domain-like0.0000002577Direct
WW domain0.0000002665Direct
VPS9 domain0.0000003065Direct
DEATH domain0.0000004474Direct
PTPA-like0.000001368Direct
Zn-finger domain of Sec23/240.00000174Direct
HLH, helix-loop-helix DNA-binding domain0.000001787Direct
Interleukin 8-like chemokines0.000003137Direct
Helical domain of Sec23/240.000003207Direct
Troponin coil-coiled subunits0.000003558Direct
BAR/IMD domain-like0.000004598Direct
Bcl-2 inhibitors of programmed cell death0.000009602Direct
Integrin alpha N-terminal domain0.00001159Direct
"Winged helix" DNA-binding domain0.00002159Direct
CSL zinc finger0.00005293Direct
IP3 receptor type 1 binding core, domain 20.00006351Direct
C-terminal, gelsolin-like domain of Sec23/240.00007925Direct
Calcium-dependent phosphotriesterase0.0001829Direct
ArfGap/RecO-like zinc finger0.0001848Direct
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.000192Direct
SEA domain0.0002409Direct
SH2 domain0.0003951Direct
PP2C-like0.0004273Direct
vWA-like0.0004302Direct
FF domain0.0004962Direct
PapD-like0.0008181Direct
Chaperone J-domain0.0009628Direct
dsRNA-binding domain-like0.01971Inherited
ENTH/VHS domain0.02035Inherited
GAT-like domain0.02413Inherited
Protein kinase-like (PK-like)1Inherited
Fibronectin type III0.01263Inherited
Galactose-binding domain-like0.1173Inherited
SAM/Pointed domain0.3156Inherited
Growth factor receptor domain1Inherited
4-helical cytokines0.01167Inherited
Insulin-like0.1047Inherited
Complement control module/SCR domain0.01883Inherited
TNF receptor-like0.005063Inherited
Leucine zipper domain0.7341Inherited
Nuclear receptor ligand-binding domain0.002067Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3553Inherited
Family A G protein-coupled receptor-like0.8771Inherited
DNA repair protein MutS, domain III0.003305Inherited
Nucleic acid-binding proteins0.7119Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.00582Inherited
SH3-domain0.03442Inherited
BRCT domain0.001668Inherited
beta-sandwich domain of Sec23/240.002667Inherited
ARM repeat0.01141Inherited
PX domain0.03866Inherited
Phosphoglycerate mutase-like0.03869Inherited
Ubiquitin-like0.2189Inherited
RNI-like0.1658Inherited
Succinyl-CoA synthetase domains0.00172Inherited
Tropomyosin0.2394Inherited
Cytokine0.5721Inherited
P-loop containing nucleoside triphosphate hydrolases0.4451Inherited
DNA clamp0.01819Inherited
Quinoprotein alcohol dehydrogenase-like0.008341Inherited
Caspase-like0.01942Inherited
Integrin domains0.008341Inherited
SRF-like0.009036Inherited
MIR domain0.001364Inherited
Hormone receptor domain0.909Inherited
Immunoglobulin0.0135Inherited
Cystine-knot cytokines1Inherited
Cysteine-rich domain0.1316Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.0253Inherited
TNF-like1Inherited
RING/U-box1Inherited
Homeodomain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    54236,48366
  • 54236 - Ubiquitin-like
  • 48366 - Ras GEF
  • 0Direct
    50729,82185
  • 50729 - PH domain-like
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    50985,48065
  • 50985 - RCC1/BLIP-II
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    50044,48065
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.0000000000009605Direct
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.000000001657Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0.000000008451Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.00000001032Direct
    50729,48350
  • 50729 - PH domain-like
  • 48350 - GTPase activation domain, GAP
  • 0.00000002716Direct
    48371,111347
  • 48371 - ARM repeat
  • 111347 - Rap/Ran-GAP
  • 0.00000007445Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0.0000001429Direct
    48350,54236
  • 48350 - GTPase activation domain, GAP
  • 54236 - Ubiquitin-like
  • 0.0000004611Direct
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.0000004879Direct
    48350,50044
  • 48350 - GTPase activation domain, GAP
  • 50044 - SH3-domain
  • 0.0000005867Direct
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0.00000078Direct
    46785,51206
  • 46785 - "Winged helix" DNA-binding domain
  • 51206 - cAMP-binding domain-like
  • 0.0000008802Direct
    46565,144217
  • 46565 - Chaperone J-domain
  • 144217 - CSL zinc finger
  • 0.0000008802Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0.00000174Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.000003207Direct
    82185,82185
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0.000003393Direct
    46565,52833
  • 46565 - Chaperone J-domain
  • 52833 - Thioredoxin-like
  • 0.000005411Direct
    57196,100895
  • 57196 - EGF/Laminin
  • 100895 - Kazal-type serine protease inhibitors
  • 0.00001034Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.0000217Direct
    51045,50156
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0.00002577Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.00004575Direct
    103657,50729
  • 103657 - BAR/IMD domain-like
  • 50729 - PH domain-like
  • 0.00006366Direct
    52540,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.00006907Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.0001848Direct
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0.0002233Direct
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.0003303Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0004509Direct
    55550,50729
  • 55550 - SH2 domain
  • 50729 - PH domain-like
  • 0.0004962Direct
    50729,57863
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 0.0009152Direct
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.02413Inherited
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.01971Inherited
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.09572Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.003886Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.005063Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.1775Inherited
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0.6112Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.004596Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.003136Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.01042Inherited
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2243Inherited
    100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.409Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.056Inherited
    56112,54236
  • 56112 - Protein kinase-like (PK-like)
  • 54236 - Ubiquitin-like
  • 0.02413Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.06647Inherited
    55979,55979
  • 55979 - DNA clamp
  • 55979 - DNA clamp
  • 0.01819Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.002842Inherited
    50156,52540
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02413Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.006349Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.01497Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.03457Inherited
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.879Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.01399Inherited
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.008341Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1048Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.05319Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.002842Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.02467Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.008687Inherited
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0.1775Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    48065,50729,82185
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0Direct
    50729,82185,82185
  • 50729 - PH domain-like
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    50985,48065,50729
  • 50985 - RCC1/BLIP-II
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50044,48065,50729
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.0000000000004619Direct
    57196,57196,100895
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 100895 - Kazal-type serine protease inhibitors
  • 0.00000001631Direct
    82919,53300,81995
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0.00000002128Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.0000001429Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0.0000001429Direct
    46565,52833,52833
  • 46565 - Chaperone J-domain
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.0000004611Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.00001891Direct
    51905,51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.00002289Direct
    51045,51045,50156
  • 51045 - WW domain
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0.00002577Direct
    52540,51045,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.00006907Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000125Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0002832Direct
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.03457Inherited
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2243Inherited
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.409Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.02855Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.009136Inherited
    50156,52540,51045
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.02413Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.01497Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.01497Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.03457Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.08588Inherited
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.008341Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.02413Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.002829Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
    Plot tree as:   Download Newick format tree:   Browsing in Tree_gateway:
    (show help)