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Biological Process (BP): cellular response to stimulus

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Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + 2:   biological_process [GO:0008150] <24>
+ 1:   cellular process [GO:0009987] <21>(372|486) (1162|1371|744)
+ 1:   response to stimulus [GO:0050896] <16>(133|153) (688|755|432)
0:   cellular response to stimulus [GO:0051716] <12>(88|98) (521|550|312)
- 1:   signal transduction [GO:0007165] <42>(43|39) (314|330|196)
- 1:   cellular response to stress [GO:0033554] <39>(36|46) (290|225|114)
- 1:   cellular response to chemical stimulus [GO:0070887] <34>(47|54) (352|295|150)
- 1:   cellular response to abiotic stimulus [GO:0071214] <9>(3|2) (84|49|17)
- 1:   cellular response to extracellular stimulus [GO:0031668] <9>(6|4) (89|48|23)
- 1:   cellular response to biotic stimulus [GO:0071216] <7>(3|2) (27|19|8)
- 1:   cellular response to lipoprotein particle stimulus [GO:0071402] <5>(0|0) (9|6|2)
- 1:   cellular pigment accumulation [GO:0043482] <1>(0|0) (4|3|2)
- 1:   cellular response to cell wall damage [GO:1990394](0|0) (0|0|0)
- 1:   cellular response to differentiation-inducing factor 2 [GO:0061862](0|0) (0|0|0)
- 1:   positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646](0|0) (0|0|0)
- 1:   skeletal muscle fiber adaptation [GO:0043503](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
"Helical backbone" metal receptor0.000000042730.00002378Direct
14-3-3 protein0.000074170.0001765Direct
ABC transporter involved in vitamin B12 uptake, BtuC0.0000043640.0002908Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.000063320Direct
Bcl-2 inhibitors of programmed cell death0.000000000000029080.0000000000003704Direct
Cu,Zn superoxide dismutase-like0.00000000080680.0000001297Direct
Cystine-knot cytokines0.0000048990Direct
Cytokine0.0000071430Direct
DNA-glycosylase0.0000000000000046850Direct
E set domains0.00025880.000000002554Direct
Family A G protein-coupled receptor-like00Direct
Histidine-containing phosphotransfer domain, HPT domain0.00000060130.0000001171Direct
Immunoglobulin00Direct
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain00.00000001512Direct
Interleukin 8-like chemokines00Direct
Metallothionein00Direct
P-loop containing nucleoside triphosphate hydrolases0.00000000016130.00000003797Direct
Protein kinase-like (PK-like)0.000000000000010610Direct
Regulator of G-protein signaling, RGS0.000028620.000000000001788Direct
Roadblock/LC7 domain0.0000000000016460.000000002486Direct
Transducin (heterotrimeric G protein), gamma chain0.00000000000019530.00000000000001254Direct
Uracil-DNA glycosylase-like0.00000000000043850Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.77181Inherited
Acyl-CoA N-acyltransferases (Nat)11Inherited
Gamma-glutamyl cyclotransferase-like0.36411Inherited
Cysteine proteinases0.005991Inherited
HLH, helix-loop-helix DNA-binding domain0.016240.00001511Inherited
HIT-like0.056630.1957Inherited
Ribonuclease H-like0.049560.4339Inherited
NAD(P)-linked oxidoreductase0.11011Inherited
Aquaporin-like0.091660.9514Inherited
EF-hand0.000000039730.0438Inherited
(Trans)glycosidases0.2011Inherited
Mitochondrial carrier11Inherited
Annexin0.020710.7042Inherited
UDP-Glycosyltransferase/glycogen phosphorylase11Inherited
alpha/beta-Hydrolases11Inherited
Cytochrome P4500.03711Inherited
Stathmin0.0021440.1447Inherited
C-terminal domain of transcriptional repressors0.000015510.06867Inherited
Periplasmic binding protein-like II0.92110.03192Inherited
Carbohydrate phosphatase0.079440.5792Inherited
Caspase-like0.00029350.0285Inherited
Bet v1-like0.1330.8341Inherited
Peptide methionine sulfoxide reductase0.028840.05296Inherited
NAD(P)-binding Rossmann-fold domains11Inherited
Class I glutamine amidotransferase-like0.15791Inherited
SNF-like0.27051Inherited
KRAB domain (Kruppel-associated box)0.97561Inherited
4-helical cytokines0.00000023780.01325Inherited
Clavaminate synthase-like0.094631Inherited
The spindle assembly checkpoint protein mad20.000520.595Inherited
ISP domain0.088161Inherited
Acetyl-CoA synthetase-like11Inherited
Carbonic anhydrase0.00092650.4307Inherited
UBC-like0.083390.2171Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.23930.7996Inherited
Metallo-dependent hydrolases0.00090030.7533Inherited
Ubiquitin-like0.5190.0000000000004453Inherited
ERO1-like0.068120.06867Inherited
Thioredoxin-like0.024481Inherited
DNase I-like0.015720.0005182Inherited
WD40 repeat-like0.22671Inherited
all-alpha NTP pyrophosphatases0.066930.3918Inherited
Heme-dependent catalase-like0.03150.02846Inherited
ALDH-like11Inherited
Defensin-like0.00079850.005888Inherited
Lipocalins0.000026970.07275Inherited
Radical SAM enzymes11Inherited
Serpins0.16990.5345Inherited
PDZ domain-like0.044090.0001708Inherited
Nucleoside diphosphate kinase, NDK0.36690.9933Inherited
Ankyrin repeat0.14880.6588Inherited
LanC-like0.0020940.01719Inherited
Cupredoxins0.080231Inherited
Insulin-like0.10440.09748Inherited
CheY-like0.0015660Inherited
DNA/RNA polymerases0.04680.0000009684Inherited
Nudix0.006140.2287Inherited
TFB5-like0.00037160.00358Inherited
Restriction endonuclease-like0.32950.00000000272Inherited
Histone-fold0.80510.8786Inherited
Xylose isomerase-like0.40970.6302Inherited
Flavoproteins0.071210.04261Inherited
NAP-like0.06940.02935Inherited
RNI-like10.4943Inherited
L domain-like0.2130Inherited
C-type lectin-like0.096120.1435Inherited


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Family

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
14-3-3 protein0.00025340.0007233Direct
3-Methyladenine DNA glycosylase I (Tag)0.000000011980.000002038Direct
AlkB-like0.0000095170.000003697Direct
Bcl-2 inhibitors of programmed cell death0.000000000000045220.000000000001208Direct
Bee venom hyaluronidase0.0000000000093230.00000000000001867Direct
CheY-related0.00054880Direct
Cu,Zn superoxide dismutase-like0.0000000010970.000000283Direct
Defensin0.00000014860.00001773Direct
DNA gyrase/MutL, N-terminal domain0.00000089070.0000001843Direct
DNA repair glycosylase, 2 C-terminal domains00.000002134Direct
Endonuclease III0.0000092980.00000000000125Direct
Endonuclease IV0.000015680.00001904Direct
Ephrin ectodomain0.000015140.00000000000004955Direct
Fibroblast growth factors (FGF)0.000000004950Direct
G proteins0.0000000000000022720.00000000000006792Direct
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain00.00000002958Direct
Interleukin 17F, IL-17F0.00010160.0003408Direct
Interleukin 8-like chemokines00Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0.00099180Direct
Metallothionein00.000000000000001589Direct
Mug-like0.00000000020670.000000001647Direct
Phosphorelay protein-like0.000000028610.0000005282Direct
Protein kinases, catalytic subunit00Direct
RecA protein-like (ATPase-domain)0.0000065150.0000000007549Direct
Regulator of G-protein signaling, RGS0.000029130.000000000003458Direct
Renal dipeptidase0.00000000000044040.0000001775Direct
Rhodopsin-like00Direct
Roadblock/LC7 domain0.000000000076660.00000007575Direct
RuvC resolvase0.0000016360.00001904Direct
Short-chain cytokines0.000000000008670.00000000008929Direct
TM0189-like0.00000021530.0000009753Direct
Transducin (heterotrimeric G protein), gamma chain0.00000000000024060.00000000000004955Direct
V set domains (antibody variable domain-like)00Direct
Proteasome subunits0.591Inherited
N-acetyl transferase, NAT0.62221Inherited
HLH, helix-loop-helix DNA-binding domain0.016910.0001425Inherited
HIT (HINT, histidine triad) family of protein kinase-interacting proteins0.082690.6372Inherited
Aldo-keto reductases (NADP)0.26951Inherited
Aquaporin-like0.18531Inherited
Quinone reductase0.31280.181Inherited
Mitochondrial carrier11Inherited
Amylase, catalytic domain0.00053181Inherited
Annexin0.022450.7304Inherited
UDPGT-like0.13470.9141Inherited
Cytochrome P4500.091551Inherited
Stathmin0.0021390.1521Inherited
ABC transporter involved in vitamin B12 uptake, BtuC0.000070380.001767Inherited
ABC transporter ATPase domain-like10.03599Inherited
Calmodulin-like0.0026990.2201Inherited
Phosphate binding protein-like0.41050.0006625Inherited
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0.067410.5567Inherited
FUR-like0.47880.7668Inherited
Caspase catalytic domain0.00032130.01357Inherited
Carboxylesterase0.76261Inherited
Penicillin synthase-like0.66811Inherited
Peptide methionine sulfoxide reductase0.028180.05649Inherited
Tyrosine-dependent oxidoreductases11Inherited
DJ-1/PfpI0.00030220.06202Inherited
S100 proteins0.0019830.07671Inherited
SNF-like0.35581Inherited
KRAB domain (Kruppel-associated box)0.97921Inherited
CAF1-like ribonuclease0.19260.1241Inherited
Long-chain cytokines0.11811Inherited
TBP-associated factors, TAFs0.051150.1901Inherited
The spindle assembly checkpoint protein mad20.00054880.3901Inherited
Acetyl-CoA synthetase-like11Inherited
Carbonic anhydrase0.0018430.5792Inherited
UBC-related0.065510.9511Inherited
Tetratricopeptide repeat (TPR)11Inherited
Ubiquitin-related0.98330.9432Inherited
Trehalose-6-phosphate synthase, OtsA0.0037740.03782Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.00034831Inherited
ERO1-like0.065390.07203Inherited
Glutathione peroxidase-like0.017860.3728Inherited
Thioltransferase0.0018310.2099Inherited
GABARAP-like0.17650.5183Inherited
WD40-repeat0.082471Inherited
Heme-dependent catalases0.032410.02628Inherited
ALDH-like11Inherited
Interferons/interleukin-10 (IL-10)0.020930.4309Inherited
Retinol binding protein-like0.00000052910.002291Inherited
Serpins0.18230.7002Inherited
RhoGDI-like0.00087410.137Inherited
Nucleoside diphosphate kinase, NDK0.36890.9789Inherited
Ankyrin repeat0.2831Inherited
Insulin-like0.10520.1278Inherited
DnaQ-like 3'-5' exonuclease0.10510.009821Inherited
DNase I-like0.0075890.00000194Inherited
TFB5-like0.00060250.005252Inherited
Uracil-DNA glycosylase0.004230.0001247Inherited
Nucleosome core histones11Inherited
Ribonucleotide reductase-like0.029330.9906Inherited
PAPS sulfotransferase0.017860.3304Inherited
NAP-like0.078850.052Inherited
MutT-like0.022080.3364Inherited
C-type lectin domain0.22970.391Inherited
C1 set domains (antibody constant domain-like)0.28020.0000000000001154Inherited
Papain-like0.00091890.7846Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Uracil-DNA glycosylase-like0Direct
Protein kinase-like (PK-like)0Direct
DNA-glycosylase0Direct
Family A G protein-coupled receptor-like0Direct
Metallothionein0Direct
L domain-like0Direct
CheY-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
Periplasmic binding protein-like I0Direct
SMAD/FHA domain0Direct
SPOC domain-like0Direct
Toll/Interleukin receptor TIR domain0Direct
PH domain-like0Direct
Homodimeric domain of signal transducing histidine kinase0Direct
Immunoglobulin0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
BRCT domain0Direct
Ras GEF0Direct
SH2 domain0Direct
Transcription factor STAT-4 N-domain0Direct
Growth factor receptor domain0Direct
Hormone receptor domain0Direct
MHC antigen-recognition domain0Direct
GTPase activation domain, GAP0Direct
SMAD MH1 domain0Direct
Cytokine0Direct
p53-like transcription factors0Direct
Cystine-knot cytokines0Direct
Interleukin 8-like chemokines0Direct
Transducin (alpha subunit), insertion domain0Direct
DEATH domain0Direct
Plexin repeat0Direct
Cysteine-rich domain0Direct
Leucine zipper domain0Direct
Crustacean CHH/MIH/GIH neurohormone0Direct
YAP1 redox domain0Direct
STAT0Direct
FLJ32549 C-terminal domain-like0Direct
p53 tetramerization domain0Direct
FLJ32549 domain-like0Direct
5' to 3' exonuclease, C-terminal subdomain9.676e-16Direct
Sema domain9.676e-16Direct
Transducin (heterotrimeric G protein), gamma chain0.000000000000006464Direct
Frizzled cysteine-rich domain0.00000000000002755Direct
TNF-like0.0000000000001211Direct
RuvA domain 2-like0.0000000000001235Direct
Bcl-2 inhibitors of programmed cell death0.0000000000001996Direct
Ubiquitin-like0.0000000000002405Direct
TNF receptor-like0.0000000000004148Direct
Fibronectin type III0.0000000000008001Direct
Regulator of G-protein signaling, RGS0.0000000000009832Direct
dsRNA-binding domain-like0.000000000001491Direct
ATP-dependent DNA ligase DNA-binding domain0.00000000000195Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000000004267Direct
WGR domain-like0.00000000001298Direct
N-terminal domain of MutM-like DNA repair proteins0.00000000002546Direct
DNA repair protein MutS, domain III0.00000000002987Direct
cAMP-binding domain-like0.00000000003733Direct
Nicotinic receptor ligand binding domain-like0.00000000004731Direct
DNA clamp0.0000000001943Direct
DNA mismatch repair protein MutL0.0000000002248Direct
C-terminal domain of Ku800.0000000002822Direct
Methylated DNA-protein cysteine methyltransferase domain0.0000000004429Direct
SH3-domain0.0000000006644Direct
RecA protein, C-terminal domain0.0000000007271Direct
Domain of poly(ADP-ribose) polymerase0.000000001067Direct
Roadblock/LC7 domain0.000000001475Direct
E set domains0.000000001516Direct
Restriction endonuclease-like0.000000001616Direct
Nuclear receptor ligand-binding domain0.000000001619Direct
Snake toxin-like0.000000002182Direct
DBL homology domain (DH-domain)0.000000002975Direct
IP3 receptor type 1 binding core, domain 20.000000003829Direct
Heparin-binding domain from vascular endothelial growth factor0.000000005738Direct
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain0.000000009194Direct
Methylated DNA-protein cysteine methyltransferase, C-terminal domain0.000000009373Direct
DNA repair protein MutS, domain I0.00000001229Direct
P-loop containing nucleoside triphosphate hydrolases0.0000000233Direct
Methuselah ectodomain0.00000003881Direct
Nucleotide cyclase0.00000004639Direct
Histidine-containing phosphotransfer domain, HPT domain0.00000007283Direct
Cu,Zn superoxide dismutase-like0.00000008072Direct
gp120 core0.00000008201Direct
Seven-hairpin glycosidases0.00000009062Direct
Zinc finger domain of DNA polymerase-alpha0.0000001534Direct
HD-domain/PDEase-like0.0000001811Direct
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)0.0000002322Direct
HAMP domain-like0.000000349Direct
RNase III domain-like0.0000003713Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.0000003713Direct
Rad51 N-terminal domain-like0.0000004728Direct
DNA/RNA polymerases0.000000619Direct
Amine oxidase N-terminal region0.000001617Direct
Glucocorticoid receptor-like (DNA-binding domain)0.000001715Direct
SAM/Pointed domain0.000001721Direct
Amine oxidase catalytic domain0.000002179Direct
HIN-2000 domain-like0.000002875Direct
Integrin beta tail domain0.000003268Direct
Nuclear receptor coactivator interlocking domain0.000003516Direct
DNA repair protein MutS, domain II0.000003792Direct
S13-like H2TH domain0.000006189Direct
ADP-ribosylation0.000007097Direct
Sporulation response regulatory protein Spo0B0.000008204Direct
Satiety factor CART (cocaine and amphetamine regulated transcript)0.000008204Direct
SAP domain0.000008302Direct
HLH, helix-loop-helix DNA-binding domain0.00001004Direct
XPC-binding domain0.00001096Direct
EGF/Laminin0.00001205Direct
BRCA2 helical domain0.00001304Direct
BRCA2 tower domain0.00001304Direct
Fe,Mn superoxide dismutase (SOD), N-terminal domain0.00001355Direct
"Helical backbone" metal receptor0.00001591Direct
AMPKBI-like0.00002057Direct
Agouti-related protein0.0000207Direct
Fe,Mn superoxide dismutase (SOD), C-terminal domain0.00002194Direct
PYP-like sensor domain (PAS domain)0.00002389Direct
Integrin domains0.00002478Direct
Fibrinogen C-terminal domain-like0.00002708Direct
Serum albumin-like0.00004868Direct
Notch domain0.00005412Direct
Orange domain-like0.00005534Direct
PIN domain-like0.00007121Direct
Porins0.00007287Direct
C-terminal autoproteolytic domain of nucleoporin nup980.00007425Direct
DNA-binding protein LAG-1 (CSL)0.00007425Direct
PAZ domain0.00007448Direct
GAF domain-like0.00009138Direct
DNA polymerase beta, N-terminal domain-like0.00009688Direct
PDZ domain-like0.0001178Direct
14-3-3 protein0.0001217Direct
alpha-ketoacid dehydrogenase kinase, N-terminal domain0.0001312Direct
N-terminal domain of cbl (N-cbl)0.0001372Direct
Cryptochrome/photolyase FAD-binding domain0.0001395Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.0001408Direct
ABC transporter involved in vitamin B12 uptake, BtuC0.0002026Direct
DNA helicase RuvA subunit, C-terminal domain0.0002414Direct
CarD-like0.0002924Direct
A DNA-binding domain in eukaryotic transcription factors0.0002924Direct
XRCC4, N-terminal domain0.0002924Direct
Suppressor of Fused, N-terminal domain0.0003406Direct
DNase I-like0.0003642Direct
Integrin alpha N-terminal domain0.0003941Direct
Cryptochrome/photolyase, N-terminal domain0.0004341Direct
Zn2/Cys6 DNA-binding domain0.0004359Direct
TRCF domain-like0.000444Direct
Kix domain of CBP (creb binding protein)0.0004757Direct
MIR domain0.0006204Direct
Rap/Ran-GAP0.0007812Direct
XRCC4, C-terminal oligomerization domain0.0008077Direct
Rad50 coiled-coil Zn hook0.0008192Direct
Trimerization domain of TRAF0.0008192Direct
Amyloid beta a4 protein copper binding domain (domain 2)0.0008582Direct
ARID-like0.7768Inherited
BRK domain-like0.6229Inherited
C-terminal domain of PLC-beta0.6584Inherited
YWTD domain0.004317Inherited
ABC transporter transmembrane region0.1082Inherited
ACT-like1Inherited
Methionine synthase activation domain-like0.4999Inherited
Methionine synthase domain0.574Inherited
Acyl-CoA N-acyltransferases (Nat)1Inherited
ClpS-like0.4616Inherited
mRNA decapping enzyme DcpS N-terminal domain0.003789Inherited
Phospholipase A2, PLA21Inherited
LuxS/MPP-like metallohydrolase1Inherited
NRDP1 C-terminal domain-like0.01136Inherited
Gamma-glutamyl cyclotransferase-like0.9461Inherited
Ricin B-like lectins0.2532Inherited
C-type lectin-like0.1151Inherited
Class II aaRS and biotin synthetases1Inherited
HIT-like0.1588Inherited
Arginase/deacetylase0.9074Inherited
Globin-like1Inherited
Methyl-accepting chemotaxis protein (MCP) signaling domain1Inherited
2Fe-2S ferredoxin-like1Inherited
FAS1 domain1Inherited
Acid proteases1Inherited
KA1-like0.002364Inherited
Inhibitor of apoptosis (IAP) repeat0.2611Inherited
TSP-1 type 1 repeat0.3058Inherited
Aquaporin-like0.8534Inherited
Carboxypeptidase regulatory domain-like0.0872Inherited
Eukaryotic type KH-domain (KH-domain type I)1Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.002577Inherited
TIMP-like0.06492Inherited
Lipovitellin-phosvitin complex, superhelical domain0.07282Inherited
Anaphylotoxins (complement system)0.5527Inherited
Zn-dependent exopeptidases1Inherited
Terpenoid cyclases/Protein prenyltransferases1Inherited
Glycosyl hydrolase domain1Inherited
Alpha-macroglobulin receptor domain1Inherited
Metal cation-transporting ATPase, ATP-binding domain N1Inherited
Prefoldin0.9974Inherited
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0.8578Inherited
NAC domain0.4415Inherited
Translation proteins1Inherited
BPTI-like0.08273Inherited
(Trans)glycosidases1Inherited
TSP type-3 repeat0.004143Inherited
BAR/IMD domain-like0.4191Inherited
Stathmin0.1161Inherited
Actin depolymerizing proteins1Inherited
EPT/RTPC-like0.5287Inherited
DUSP-like1Inherited
TB module/8-cys domain0.004582Inherited
Kelch motif0.9615Inherited
C-terminal, gelsolin-like domain of Sec23/241Inherited
PEP carboxykinase-like0.04544Inherited
AN1-like Zinc finger0.07098Inherited
PEP carboxykinase N-terminal domain0.05265Inherited
NAP-like0.02244Inherited
EF-G C-terminal domain-like1Inherited
PAP/OAS1 substrate-binding domain1Inherited
Metalloproteases ("zincins"), catalytic domain1Inherited
Composite domain of metallo-dependent hydrolases0.306Inherited
Rudiment single hybrid motif1Inherited
Probable ACP-binding domain of malonyl-CoA ACP transacylase1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
ClpP/crotonase1Inherited
FabD/lysophospholipase-like1Inherited
Thiolase-like1Inherited
PreATP-grasp domain1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Single hybrid motif1Inherited
SpoIIaa-like1Inherited
Periplasmic binding protein-like II0.02445Inherited
C-terminal domain of ProRS0.1249Inherited
Sigma2 domain of RNA polymerase sigma factors0.3065Inherited
Sigma3 and sigma4 domains of RNA polymerase sigma factors0.3065Inherited
C-terminal domain of transcriptional repressors0.0538Inherited
TolA/TonB C-terminal domain0.3771Inherited
FMN-dependent nitroreductase-like0.6915Inherited
Heme oxygenase-like0.2724Inherited
L-aspartase-like1Inherited
OMPA-like1Inherited
Cyclophilin-like1Inherited
Caspase-like0.02178Inherited
MgtE membrane domain-like0.2068Inherited
Smc hinge domain0.9356Inherited
Bactericidal permeability-increasing protein, BPI0.8746Inherited
Kringle-like0.0636Inherited
Chlorophyll a-b binding protein0.6722Inherited
RmlC-like cupins1Inherited
Calpain large subunit, middle domain (domain III)0.00411Inherited
FnI-like domain0.4916Inherited
Chitinase insertion domain0.02225Inherited
Heme-dependent peroxidases0.1314Inherited
V-type ATP synthase subunit C0.0377Inherited
Peptide methionine sulfoxide reductase0.04113Inherited
DNA-binding domain of EIN3-like0.00925Inherited
TPR-like1Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain1Inherited
DHS-like NAD/FAD-binding domain1Inherited
beta-beta-alpha zinc fingers1Inherited
Nucleotide-diphospho-sugar transferases1Inherited
Ran binding protein zinc finger-like0.0281Inherited
N-acetylmuramoyl-L-alanine amidase-like1Inherited
Nucleoplasmin-like core domain0.195Inherited
PGBD-like0.5071Inherited
Hemopexin-like domain0.7173Inherited
Pseudo ankyrin repeat-like1Inherited
BEACH domain0.3418Inherited
Hypothetical protein AF0491, middle domain0.4999Inherited
FYSH domain0.574Inherited
SNF-like1Inherited
Ankyrin repeat0.5703Inherited
NAD kinase/diacylglycerol kinase-like0.01715Inherited
HMG-box0.5155Inherited
Band 7/SPFH domain1Inherited
Formate/glycerate dehydrogenase catalytic domain-like1Inherited
Concanavalin A-like lectins/glucanases1Inherited
GLA-domain0.2549Inherited
ArfGap/RecO-like zinc finger0.578Inherited
4-helical cytokines0.009907Inherited
CCCH zinc finger0.8932Inherited
Mitochondrial glycoprotein MAM33-like0.144Inherited
Subdomain of clathrin and coatomer appendage domain0.8944Inherited
Clathrin adaptor appendage domain1Inherited
Cupredoxins1Inherited
Galactose-binding domain-like0.02564Inherited
Hairpin loop containing domain-like0.908Inherited
Thyroglobulin type-1 domain1Inherited
KRAB domain (Kruppel-associated box)1Inherited
PAH2 domain0.6229Inherited
Thioesterase/thiol ester dehydrase-isomerase1Inherited
Tetraspanin0.06094Inherited
SWIB/MDM2 domain0.5676Inherited
all-alpha NTP pyrophosphatases0.3287Inherited
Class I glutamine amidotransferase-like1Inherited
Activating enzymes of the ubiquitin-like proteins1Inherited
N-terminal domain of alpha and beta subunits of F1 ATP synthase0.8356Inherited
C-terminal domain of alpha and beta subunits of F1 ATP synthase0.9527Inherited
Moesin tail domain0.409Inherited
SRF-like0.5637Inherited
Cullin repeat-like0.3951Inherited
Formin homology 2 domain (FH2 domain)0.3948Inherited
UBC-like0.1769Inherited
RING/U-box0.6899Inherited
Cullin homology domain0.1272Inherited
Spermadhesin, CUB domain0.2247Inherited
Eferin C-derminal domain-like0.9719Inherited
Metallo-dependent hydrolases0.659Inherited
Carbohydrate phosphatase0.4971Inherited
PP2C-like0.1075Inherited
Trimeric LpxA-like enzymes1Inherited
PRTase-like1Inherited
G protein-binding domain0.006873Inherited
Sensory domain-like0.02759Inherited
C-terminal effector domain of the bipartite response regulators0.4393Inherited
MAST3 pre-PK domain-like0.1249Inherited
EF-hand0.03382Inherited
Lipoxigenase0.7699Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)1Inherited
Spectrin repeat1Inherited
Calponin-homology domain, CH-domain1Inherited
PUG domain-like0.1975Inherited
HSP90 C-terminal domain1Inherited
Calcium ATPase, transmembrane domain M1Inherited
Calcium ATPase, transduction domain A1Inherited
HCP-like1Inherited
Bromodomain1Inherited
Rubredoxin-like0.8135Inherited
Double Clp-N motif0.6639Inherited
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 30.3942Inherited
HMA, heavy metal-associated domain0.7993Inherited
Zinc beta-ribbon1Inherited
Ribosomal protein S5 domain 2-like1Inherited
UBA-like0.3224Inherited
ADC-like0.3815Inherited
Cdc48 domain 2-like0.007375Inherited
Cyclin-like0.01111Inherited
AhpD-like0.1745Inherited
Chromo domain-like1Inherited
ERO1-like0.0538Inherited
Mannose 6-phosphate receptor domain0.02968Inherited
Assembly domain of cartilage oligomeric matrix protein0.01503Inherited
GAS2 domain-like0.8757Inherited
Lipocalins0.05708Inherited
CalX-like0.004167Inherited
ARM repeat0.1132Inherited
E2F-DP heterodimerization region0.0914Inherited
"Winged helix" DNA-binding domain0.00466Inherited
Nudix0.1869Inherited
vWA-like0.001721Inherited
post-AAA+ oligomerization domain-like0.03536Inherited
The spindle assembly checkpoint protein mad20.5115Inherited
Ribonuclease H-like0.3662Inherited
GIY-YIG endonuclease0.01079Inherited
C-terminal UvrC-binding domain of UvrB0.0109Inherited
LexA/Signal peptidase0.01485Inherited
PHP domain-like0.1148Inherited
Hect, E3 ligase catalytic domain0.932Inherited
DNA topoisomerase IV, alpha subunit0.1058Inherited
Nucleic acid-binding proteins0.2477Inherited
TFB5-like0.002612Inherited
PsbU/PolX domain-like0.001431Inherited
Ada DNA repair protein, N-terminal domain (N-Ada 10)0.0214Inherited
HRDC-like0.03623Inherited
Polo-box domain0.002202Inherited
JAB1/MPN domain0.004337Inherited
Macro domain-like0.3666Inherited
Fzo-like conserved region0.07067Inherited
ASF1-like0.1058Inherited
ERP29 C domain-like0.1249Inherited
TRAF domain-like0.08108Inherited
WD40 repeat-like1Inherited
Multidrug efflux transporter AcrB transmembrane domain0.8733Inherited
Carbonic anhydrase0.3633Inherited
Mitochondrial carrier1Inherited
Annexin0.6128Inherited
DNA-binding domain0.04441Inherited
F-box domain1Inherited
CAD & PB1 domains1Inherited
Ypt/Rab-GAP domain of gyp1p1Inherited
SOCS box-like0.01704Inherited
FAD/NAD(P)-binding domain1Inherited
eIF2alpha middle domain-like0.5716Inherited
eIF-2-alpha, C-terminal domain0.5716Inherited
Phenylalanine zipper0.001465Inherited
FF domain0.6098Inherited
LigT-like0.1975Inherited
Apolipoprotein A-I0.9464Inherited
Intermediate filament protein, coiled coil region1Inherited
Hook domain0.9043Inherited
Cap-Gly domain1Inherited
Retrovirus zinc finger-like domains1Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.9238Inherited
Actin-like ATPase domain1Inherited
Chaperone J-domain1Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain1Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain1Inherited
PA domain0.9498Inherited
P-domain of calnexin/calreticulin0.5612Inherited
Quinoprotein alcohol dehydrogenase-like0.08299Inherited
Rhomboid-like0.01655Inherited
PapD-like0.1927Inherited
Subtilisin-like1Inherited
Sec63 N-terminal domain-like0.02084Inherited
Cysteine proteinases1Inherited
HSP40/DnaJ peptide-binding domain0.5949Inherited
ALDH-like1Inherited
FYVE/PHD zinc finger1Inherited
SET domain1Inherited
Glycerol-3-phosphate (1)-acyltransferase1Inherited
Cystatin/monellin1Inherited
HIT/MYND zinc finger-like1Inherited
YgaC/TfoX-N like0.02438Inherited
Alkaline phosphatase-like0.9703Inherited
Zn-binding ribosomal proteins1Inherited
Defensin-like0.004337Inherited
CRAL/TRIO domain0.3342Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain1Inherited
Second domain of FERM0.8134Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
Cadherin-like1Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor1Inherited
HAD-like1Inherited
Phosphoglycerate mutase-like1Inherited
MFS general substrate transporter1Inherited
ACP-like1Inherited
CoA-dependent acyltransferases1Inherited
Heme-dependent catalase-like0.02174Inherited
WRKY DNA-binding domain0.3692Inherited
Homeodomain-like1Inherited
DnaJ/Hsp40 cysteine-rich domain0.6862Inherited
lambda repressor-like DNA-binding domains1Inherited
Type II DNA topoisomerase0.9276Inherited
Radical SAM enzymes1Inherited
Nop domain0.5503Inherited
CBS-domain pair1Inherited
YVTN repeat-like/Quinoprotein amine dehydrogenase0.5549Inherited
TGS-like0.7975Inherited
LDL receptor-like module0.04981Inherited
NHL repeat0.853Inherited
B-box zinc-binding domain0.9706Inherited
Pectin lyase-like1Inherited
RNA-binding domain, RBD1Inherited
Trypsin-like serine proteases1Inherited
Serpins0.4564Inherited
SAICAR synthase-like0.4885Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.7033Inherited
Phospholipase D/nuclease0.2037Inherited
PX domain0.3232Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases1Inherited
ValRS/IleRS/LeuRS editing domain1Inherited
RGC domain-like0.186Inherited
RUN domain-like1Inherited
Ligand-binding domain in the NO signalling and Golgi transport0.3556Inherited
POZ domain1Inherited
Riboflavin synthase domain-like0.004312Inherited
Nitric oxide (NO) synthase oxygenase domain0.1524Inherited
Nucleoside diphosphate kinase, NDK0.8965Inherited
Hedgehog/intein (Hint) domain0.08528Inherited
Hedgehog/DD-peptidase0.0359Inherited
TAZ domain0.009561Inherited
WWE domain0.07724Inherited
Mib/herc2 domain-like0.2519Inherited
PKD domain0.2809Inherited
Oligoxyloglucan reducing end-specific cellobiohydrolase0.3184Inherited
Tropomyosin1Inherited
Voltage-gated potassium channels0.001015Inherited
Complement control module/SCR domain1Inherited
LanC-like0.01295Inherited
RNI-like0.42Inherited
(Phosphotyrosine protein) phosphatases II0.01651Inherited
SAND domain-like1Inherited
WW domain0.01524Inherited
Nucleoporin domain0.00372Inherited
GYF domain0.8812Inherited
VHP, Villin headpiece domain0.7639Inherited
FAT domain of focal adhesion kinase0.2952Inherited
Insulin-like0.07722Inherited
GDNF receptor-like0.008301Inherited
Blood coagulation inhibitor (disintegrin)0.04681Inherited
A heparin-binding domain0.007463Inherited
CAPPD, an extracellular domain of amyloid beta A4 protein0.01135Inherited
Class II MHC-associated invariant chain ectoplasmic trimerization domain0.003673Inherited
Aminoacid dehydrogenase-like, N-terminal domain1Inherited
Clavaminate synthase-like1Inherited
Histone-fold0.7804Inherited
Metallo-hydrolase/oxidoreductase1Inherited
Metallo-dependent phosphatases0.07399Inherited
Tumor suppressor gene product Apc0.001465Inherited
N-terminal coiled coil domain from apc0.001465Inherited
BSD domain-like0.1821Inherited
TATA-box binding protein-like0.9775Inherited
ssDNA-binding transcriptional regulator domain0.04673Inherited
Recombination protein RecR0.1789Inherited
Xylose isomerase-like0.5439Inherited
Prokaryotic type I DNA topoisomerase0.6546Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like1Inherited
ISP domain1Inherited
MAPEG domain-like0.5439Inherited
GroES-like1Inherited
Cytochrome P4501Inherited
alpha/beta-Hydrolases1Inherited
4Fe-4S ferredoxins1Inherited
UDP-Glycosyltransferase/glycogen phosphorylase1Inherited
Thioredoxin-like0.9809Inherited
NAD(P)-linked oxidoreductase1Inherited
Bet v1-like0.7366Inherited
GST C-terminal domain-like1Inherited
Acetyl-CoA synthetase-like1Inherited
Flavoproteins0.03288Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.006186Inherited
Tudor/PWWP/MBT1Inherited
Putative DNA-binding domain0.9913Inherited
Nucleotidyltransferase1Inherited
FMT C-terminal domain-like0.7066Inherited
PLC-like phosphodiesterases0.4744Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
Fibrinogen coiled-coil and central regions0.1126Inherited
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain0.08949Inherited
Phase 1 flagellin0.7074Inherited
Virus ectodomain0.002364Inherited
SEA domain0.1157Inherited
Serine protease inhibitors0.9195Inherited
Triple coiled coil domain of C-type lectins0.06847Inherited
PriA/YqbF domain0.9087Inherited
GINS helical bundle-like0.9816Inherited
EAL domain-like0.9341Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49879,52113
  • 49879 - SMAD/FHA domain
  • 52113 - BRCT domain
  • 0Direct
    46785,57903
  • 46785 - "Winged helix" DNA-binding domain
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    50998,56112
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54001,55205
  • 54001 - Cysteine proteinases
  • 55205 - EPT/RTPC-like
  • 0Direct
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0Direct
    54928,111331
  • 54928 - RNA-binding domain, RBD
  • 111331 - NAD kinase/diacylglycerol kinase-like
  • 0Direct
    58006,57196
  • 58006 - Assembly domain of cartilage oligomeric matrix protein
  • 57196 - EGF/Laminin
  • 0Direct
    103652,50729
  • 103652 - G protein-binding domain
  • 50729 - PH domain-like
  • 0Direct
    55785,55890
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55890 - Sporulation response regulatory protein Spo0B
  • 0Direct
    47384,55874
  • 47384 - Homodimeric domain of signal transducing histidine kinase
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 0Direct
    50370,56436
  • 50370 - Ricin B-like lectins
  • 56436 - C-type lectin-like
  • 0Direct
    103190,55785
  • 103190 - Sensory domain-like
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0Direct
    46946,57716
  • 46946 - S13-like H2TH domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    52540,49899
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    55890,55874
  • 55890 - Sporulation response regulatory protein Spo0B
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    46934,56219
  • 46934 - UBA-like
  • 56219 - DNase I-like
  • 0Direct
    54236,54928
  • 54236 - Ubiquitin-like
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    103575,81296
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 0Direct
    143791,54236
  • 143791 - DUSP-like
  • 54236 - Ubiquitin-like
  • 0Direct
    52113,56672
  • 52113 - BRCT domain
  • 56672 - DNA/RNA polymerases
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    81606,55073
  • 81606 - PP2C-like
  • 55073 - Nucleotide cyclase
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50729,57997
  • 50729 - PH domain-like
  • 57997 - Tropomyosin
  • 0Direct
    57440,81901
  • 57440 - Kringle-like
  • 81901 - HCP-like
  • 0Direct
    57889,111331
  • 57889 - Cysteine-rich domain
  • 111331 - NAD kinase/diacylglycerol kinase-like
  • 0Direct
    158548,160651
  • 158548 - FLJ32549 domain-like
  • 160651 - FLJ32549 C-terminal domain-like
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    56300,101447
  • 56300 - Metallo-dependent phosphatases
  • 101447 - Formin homology 2 domain (FH2 domain)
  • 0Direct
    57850,50978
  • 57850 - RING/U-box
  • 50978 - WD40 repeat-like
  • 0Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    100939,101420
  • 100939 - SPOC domain-like
  • 101420 - C-terminal domain of Ku80
  • 0.000000000000001898Direct
    55785,47384
  • 55785 - PYP-like sensor domain (PAS domain)
  • 47384 - Homodimeric domain of signal transducing histidine kinase
  • 0.000000000000001898Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.000000000000001898Direct
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.000000000000003737Direct
    53300,100939
  • 53300 - vWA-like
  • 100939 - SPOC domain-like
  • 0.00000000000001092Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.00000000000003698Direct
    53649,53649
  • 53649 - Alkaline phosphatase-like
  • 53649 - Alkaline phosphatase-like
  • 0.00000000000004042Direct
    55874,52172
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 52172 - CheY-like
  • 0.00000000000005898Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.0000000000001504Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.0000000000002029Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0000000000005602Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0.0000000000006995Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0.00000000000195Direct
    54495,54211
  • 54495 - UBC-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.000000000005512Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00000000001245Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.00000000001909Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00000000002987Direct
    81624,46946
  • 81624 - N-terminal domain of MutM-like DNA repair proteins
  • 46946 - S13-like H2TH domain
  • 0.00000000004022Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.00000000006508Direct
    54236,48366
  • 54236 - Ubiquitin-like
  • 48366 - Ras GEF
  • 0.00000000006763Direct
    142921,47587
  • 142921 - WGR domain-like
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 0.00000000006931Direct
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0.00000000007763Direct
    53850,81324
  • 53850 - Periplasmic binding protein-like II
  • 81324 - Voltage-gated potassium channels
  • 0.0000000003776Direct
    50156,103657
  • 50156 - PDZ domain-like
  • 103657 - BAR/IMD domain-like
  • 0.0000000004429Direct
    53155,46767
  • 53155 - Methylated DNA-protein cysteine methyltransferase domain
  • 46767 - Methylated DNA-protein cysteine methyltransferase, C-terminal domain
  • 0.0000000004429Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0.0000000006208Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0.000000001012Direct
    88723,47807
  • 88723 - PIN domain-like
  • 47807 - 5' to 3' exonuclease, C-terminal subdomain
  • 0.000000001067Direct
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0.000000001067Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.000000001324Direct
    52540,54752
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 54752 - RecA protein, C-terminal domain
  • 0.000000002339Direct
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.000000002524Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00000000311Direct
    158472,47384
  • 158472 - HAMP domain-like
  • 47384 - Homodimeric domain of signal transducing histidine kinase
  • 0.000000004196Direct
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.000000005095Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.000000005313Direct
    57501,57593
  • 57501 - Cystine-knot cytokines
  • 57593 - Heparin-binding domain from vascular endothelial growth factor
  • 0.000000005738Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.000000008804Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.000000009852Direct
    52058,52200
  • 52058 - L domain-like
  • 52200 - Toll/Interleukin receptor TIR domain
  • 0.00000001229Direct
    57716,117018
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 0.00000001931Direct
    52172,47226
  • 52172 - CheY-like
  • 47226 - Histidine-containing phosphotransfer domain, HPT domain
  • 0.00000002217Direct
    49879,56112
  • 49879 - SMAD/FHA domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000000238Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.00000002571Direct
    47794,52540
  • 47794 - Rad51 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00000002726Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0.00000002809Direct
    52172,46689
  • 52172 - CheY-like
  • 46689 - Homeodomain-like
  • 0.00000004228Direct
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000004571Direct
    49854,117281
  • 49854 - Spermadhesin, CUB domain
  • 117281 - Kelch motif
  • 0.00000007508Direct
    52540,48340
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48340 - Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain
  • 0.0000001413Direct
    52047,52200
  • 52047 - RNI-like
  • 52200 - Toll/Interleukin receptor TIR domain
  • 0.0000001464Direct
    50249,52113
  • 50249 - Nucleic acid-binding proteins
  • 52113 - BRCT domain
  • 0.0000001464Direct
    56672,90234
  • 56672 - DNA/RNA polymerases
  • 90234 - Zinc finger domain of DNA polymerase-alpha
  • 0.0000001534Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0000002023Direct
    47212,56112
  • 47212 - FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000002322Direct
    54416,49998
  • 54416 - Amine oxidase N-terminal region
  • 49998 - Amine oxidase catalytic domain
  • 0.000000318Direct
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.0000004385Direct
    54416,54416
  • 54416 - Amine oxidase N-terminal region
  • 54416 - Amine oxidase N-terminal region
  • 0.0000004482Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0000004767Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000004892Direct
    49899,48726
  • 49899 - Concanavalin A-like lectins/glucanases
  • 48726 - Immunoglobulin
  • 0.0000004948Direct
    52058,81321
  • 52058 - L domain-like
  • 81321 - Family A G protein-coupled receptor-like
  • 0.0000006883Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.000001064Direct
    46934,101238
  • 46934 - UBA-like
  • 101238 - XPC-binding domain
  • 0.000001098Direct
    159141,159141
  • 159141 - HIN-2000 domain-like
  • 159141 - HIN-2000 domain-like
  • 0.000001138Direct
    50729,50044
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.000001292Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.00000172Direct
    57362,109843
  • 57362 - BPTI-like
  • 109843 - CAPPD, an extracellular domain of amyloid beta A4 protein
  • 0.000001748Direct
    56968,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.000001748Direct
    69065,69065
  • 69065 - RNase III domain-like
  • 69065 - RNase III domain-like
  • 0.000002283Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.000002992Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.000003268Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0.000003857Direct
    52540,47473
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47473 - EF-hand
  • 0.000003857Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.000003887Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.00000425Direct
    46785,51306
  • 46785 - "Winged helix" DNA-binding domain
  • 51306 - LexA/Signal peptidase
  • 0.000004797Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000551Direct
    48150,55811
  • 48150 - DNA-glycosylase
  • 55811 - Nudix
  • 0.000006036Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.000006578Direct
    50249,47781
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 0.000006832Direct
    49899,52540
  • 49899 - Concanavalin A-like lectins/glucanases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000006832Direct
    100909,48371
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 48371 - ARM repeat
  • 0.000007006Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.000008069Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.000008069Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.000008188Direct
    101690,69065
  • 101690 - PAZ domain
  • 69065 - RNase III domain-like
  • 0.000008204Direct
    50729,90209
  • 50729 - PH domain-like
  • 90209 - Ran binding protein zinc finger-like
  • 0.000008204Direct
    100909,49899
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000008715Direct
    54631,54631
  • 54631 - CBS-domain pair
  • 54631 - CBS-domain pair
  • 0.000008946Direct
    55979,55979
  • 55979 - DNA clamp
  • 55979 - DNA clamp
  • 0.000008946Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.000009041Direct
    47473,52540
  • 47473 - EF-hand
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000009693Direct
    69065,54768
  • 69065 - RNase III domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.00001061Direct
    50249,81878
  • 50249 - Nucleic acid-binding proteins
  • 81878 - BRCA2 tower domain
  • 0.00001304Direct
    81872,50249
  • 81872 - BRCA2 helical domain
  • 50249 - Nucleic acid-binding proteins
  • 0.00001304Direct
    81878,50249
  • 81878 - BRCA2 tower domain
  • 50249 - Nucleic acid-binding proteins
  • 0.00001304Direct
    46609,54719
  • 46609 - Fe,Mn superoxide dismutase (SOD), N-terminal domain
  • 54719 - Fe,Mn superoxide dismutase (SOD), C-terminal domain
  • 0.00001355Direct
    48670,48097
  • 48670 - Transducin (heterotrimeric G protein), gamma chain
  • 48097 - Regulator of G-protein signaling, RGS
  • 0.00001383Direct
    51045,50156
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0.00001383Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.00001436Direct
    53150,48334
  • 53150 - DNA repair protein MutS, domain II
  • 48334 - DNA repair protein MutS, domain III
  • 0.00002057Direct
    48371,48350
  • 48371 - ARM repeat
  • 48350 - GTPase activation domain, GAP
  • 0.0000207Direct
    56112,50729
  • 56112 - Protein kinase-like (PK-like)
  • 50729 - PH domain-like
  • 0.00002756Direct
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.00003441Direct
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.00003628Direct
    52540,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.00003819Direct
    54236,49879
  • 54236 - Ubiquitin-like
  • 49879 - SMAD/FHA domain
  • 0.00004385Direct
    47473,55550
  • 47473 - EF-hand
  • 55550 - SH2 domain
  • 0.00004385Direct
    47912,47912
  • 47912 - Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
  • 47912 - Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
  • 0.00006073Direct
    50044,140741
  • 50044 - SH3-domain
  • 140741 - RUN domain-like
  • 0.00006073Direct
    50729,49562
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.00006122Direct
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.00006555Direct
    50729,48366
  • 50729 - PH domain-like
  • 48366 - Ras GEF
  • 0.00007085Direct
    46565,52833
  • 46565 - Chaperone J-domain
  • 52833 - Thioredoxin-like
  • 0.00007085Direct
    56112,82615
  • 56112 - Protein kinase-like (PK-like)
  • 82615 - Polo-box domain
  • 0.00007104Direct
    49417,110217
  • 49417 - p53-like transcription factors
  • 110217 - DNA-binding protein LAG-1 (CSL)
  • 0.00007425Direct
    56502,56502
  • 56502 - gp120 core
  • 56502 - gp120 core
  • 0.00007851Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.00009454Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.00009925Direct
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.0001094Direct
    55550,57850
  • 55550 - SH2 domain
  • 57850 - RING/U-box
  • 0.0001372Direct
    47668,47473
  • 47668 - N-terminal domain of cbl (N-cbl)
  • 47473 - EF-hand
  • 0.0001372Direct
    69012,55874
  • 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 0.0001512Direct
    46785,51206
  • 46785 - "Winged helix" DNA-binding domain
  • 51206 - cAMP-binding domain-like
  • 0.0001512Direct
    47781,102712
  • 47781 - RuvA domain 2-like
  • 102712 - JAB1/MPN domain
  • 0.000167Direct
    82895,57196
  • 82895 - TSP-1 type 1 repeat
  • 57196 - EGF/Laminin
  • 0.000167Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.0001783Direct
    100939,68906
  • 100939 - SPOC domain-like
  • 68906 - SAP domain
  • 0.0001797Direct
    52172,52172
  • 52172 - CheY-like
  • 52172 - CheY-like
  • 0.0001797Direct
    47473,57889
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0.0001982Direct
    110217,81296
  • 110217 - DNA-binding protein LAG-1 (CSL)
  • 81296 - E set domains
  • 0.0001988Direct
    103647,49899
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0002079Direct
    52799,52799
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.0002212Direct
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.0002215Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.000229Direct
    47781,46929
  • 47781 - RuvA domain 2-like
  • 46929 - DNA helicase RuvA subunit, C-terminal domain
  • 0.0002414Direct
    46785,47819
  • 46785 - "Winged helix" DNA-binding domain
  • 47819 - HRDC-like
  • 0.0002414Direct
    52540,47819
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47819 - HRDC-like
  • 0.0002414Direct
    57716,46955
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 46955 - Putative DNA-binding domain
  • 0.0002414Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0.0002645Direct
    55781,47384
  • 55781 - GAF domain-like
  • 47384 - Homodimeric domain of signal transducing histidine kinase
  • 0.0002645Direct
    52425,48173
  • 52425 - Cryptochrome/photolyase, N-terminal domain
  • 48173 - Cryptochrome/photolyase FAD-binding domain
  • 0.00028Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0.0002923Direct
    50809,58022
  • 50809 - XRCC4, N-terminal domain
  • 58022 - XRCC4, C-terminal oligomerization domain
  • 0.0002924Direct
    52172,52540
  • 52172 - CheY-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0002931Direct
    103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.0003043Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0003048Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.0004242Direct
    52113,142921
  • 52113 - BRCT domain
  • 142921 - WGR domain-like
  • 0.0004242Direct
    57630,57184
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 0.0004242Direct
    52540,143517
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 143517 - TRCF domain-like
  • 0.000444Direct
    55550,48366
  • 55550 - SH2 domain
  • 48366 - Ras GEF
  • 0.000444Direct
    52540,141259
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 141259 - CarD-like
  • 0.000444Direct
    141259,52540
  • 141259 - CarD-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000444Direct
    50729,56024
  • 50729 - PH domain-like
  • 56024 - Phospholipase D/nuclease
  • 0.0005204Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0.0005412Direct
    55945,48150
  • 55945 - TATA-box binding protein-like
  • 48150 - DNA-glycosylase
  • 0.0005412Direct
    56784,52540
  • 56784 - HAD-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0006317Direct
    57362,57424
  • 57362 - BPTI-like
  • 57424 - LDL receptor-like module
  • 0.0006317Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0006834Direct
    49599,49599
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0.0006834Direct
    57196,48113
  • 57196 - EGF/Laminin
  • 48113 - Heme-dependent peroxidases
  • 0.0007152Direct
    101238,46934
  • 101238 - XPC-binding domain
  • 46934 - UBA-like
  • 0.0007411Direct
    47781,52113
  • 47781 - RuvA domain 2-like
  • 52113 - BRCT domain
  • 0.0008192Direct
    57953,49599
  • 57953 - Trimerization domain of TRAF
  • 49599 - TRAF domain-like
  • 0.0008192Direct
    47986,56112
  • 47986 - DEATH domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0008192Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0008379Direct
    56491,89811
  • 56491 - A heparin-binding domain
  • 89811 - Amyloid beta a4 protein copper binding domain (domain 2)
  • 0.0008582Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0009008Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0.000975Direct
    46689,46689
  • 46689 - Homeodomain-like
  • 46689 - Homeodomain-like
  • 0.9994Inherited
    103657,50729
  • 103657 - BAR/IMD domain-like
  • 50729 - PH domain-like
  • 0.06607Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.06095Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 1Inherited
    48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0.04246Inherited
    55920,46785
  • 55920 - Creatinase/aminopeptidase
  • 46785 - "Winged helix" DNA-binding domain
  • 0.1626Inherited
    64356,49447
  • 64356 - SNARE-like
  • 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
  • 0.7932Inherited
    47769,56399
  • 47769 - SAM/Pointed domain
  • 56399 - ADP-ribosylation
  • 0.03249Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07638Inherited
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.1103Inherited
    55486,57440
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57440 - Kringle-like
  • 0.03357Inherited
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0.09347Inherited
    51717,47644
  • 51717 - Dihydropteroate synthetase-like
  • 47644 - Methionine synthase domain
  • 0.4999Inherited
    52242,56507
  • 52242 - Cobalamin (vitamin B12)-binding domain
  • 56507 - Methionine synthase activation domain-like
  • 0.4999Inherited
    82282,51717
  • 82282 - Homocysteine S-methyltransferase
  • 51717 - Dihydropteroate synthetase-like
  • 0.4999Inherited
    47644,52242
  • 47644 - Methionine synthase domain
  • 52242 - Cobalamin (vitamin B12)-binding domain
  • 0.574Inherited
    48403,47986
  • 48403 - Ankyrin repeat
  • 47986 - DEATH domain
  • 0.01757Inherited
    47592,90209
  • 47592 - SWIB/MDM2 domain
  • 90209 - Ran binding protein zinc finger-like
  • 0.1903Inherited
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.01832Inherited
    102860,54197
  • 102860 - mRNA decapping enzyme DcpS N-terminal domain
  • 54197 - HIT-like
  • 0.003789Inherited
    52218,63380
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0.4704Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.06359Inherited
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 1Inherited
    49599,160088
  • 49599 - TRAF domain-like
  • 160088 - NRDP1 C-terminal domain-like
  • 0.01136Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.01508Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 1Inherited
    52058,52047
  • 52058 - L domain-like
  • 52047 - RNI-like
  • 0.005376Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.0486Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.05881Inherited
    88659,88659
  • 88659 - Sigma3 and sigma4 domains of RNA polymerase sigma factors
  • 88659 - Sigma3 and sigma4 domains of RNA polymerase sigma factors
  • 0.4337Inherited
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0.7223Inherited
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 1Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 1Inherited
    49265,56496
  • 49265 - Fibronectin type III
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.01292Inherited
    54791,54791
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 0.8913Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.06923Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.001971Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.02357Inherited
    53187,49464
  • 53187 - Zn-dependent exopeptidases
  • 49464 - Carboxypeptidase regulatory domain-like
  • 0.04246Inherited
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0.4321Inherited
    82895,57424
  • 82895 - TSP-1 type 1 repeat
  • 57424 - LDL receptor-like module
  • 0.7066Inherited
    48239,49410
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 49410 - Alpha-macroglobulin receptor domain
  • 0.761Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 1Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 1Inherited
    103657,50044
  • 103657 - BAR/IMD domain-like
  • 50044 - SH3-domain
  • 0.04481Inherited
    50729,57863
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 0.3308Inherited
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0.3609Inherited
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.09111Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00182Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.004593Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.004593Inherited
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.009494Inherited
    117281,117281
  • 117281 - Kelch motif
  • 117281 - Kelch motif
  • 0.2493Inherited
    50156,52540
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.07067Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.004344Inherited
    57184,49854
  • 57184 - Growth factor receptor domain
  • 49854 - Spermadhesin, CUB domain
  • 0.003789Inherited
    55753,47050
  • 55753 - Actin depolymerizing proteins
  • 47050 - VHP, Villin headpiece domain
  • 0.1103Inherited
    49562,53300
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 53300 - vWA-like
  • 0.08021Inherited
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.5614Inherited
    55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 1Inherited
    55753,82754
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.4933Inherited
    82754,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 0.4933Inherited
    50044,51695
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 0.1161Inherited
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0.04564Inherited
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.4849Inherited
    55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0.5638Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 1Inherited
    50447,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 1Inherited
    54980,54211
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 1Inherited
    54211,54980
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 1Inherited
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 1Inherited
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0.1115Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.00201Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.9879Inherited
    48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0.2434Inherited
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0.1063Inherited
    51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.7593Inherited
    51735,51735
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.8437Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 1Inherited
    52151,55048
  • 52151 - FabD/lysophospholipase-like
  • 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase
  • 1Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 1Inherited
    47336,53474
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 0.2981Inherited
    56112,48403
  • 56112 - Protein kinase-like (PK-like)
  • 48403 - Ankyrin repeat
  • 0.03561Inherited
    52954,64586
  • 52954 - Class II aaRS ABD-related
  • 64586 - C-terminal domain of ProRS
  • 0.1249Inherited
    88946,88659
  • 88946 - Sigma2 domain of RNA polymerase sigma factors
  • 88659 - Sigma3 and sigma4 domains of RNA polymerase sigma factors
  • 0.3841Inherited
    81324,47473
  • 81324 - Voltage-gated potassium channels
  • 47473 - EF-hand
  • 0.1126Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 1Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.3358Inherited
    48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.5204Inherited
    55073,55073
  • 55073 - Nucleotide cyclase
  • 55073 - Nucleotide cyclase
  • 0.002763Inherited
    55073,52540
  • 55073 - Nucleotide cyclase
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01136Inherited
    54695,48403
  • 54695 - POZ domain
  • 48403 - Ankyrin repeat
  • 0.2639Inherited
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 1Inherited
    55394,55394
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 0.4933Inherited
    57850,48371
  • 57850 - RING/U-box
  • 48371 - ARM repeat
  • 0.8003Inherited
    82754,82754
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.003877Inherited
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0.02225Inherited
    49599,57953
  • 49599 - TRAF domain-like
  • 57953 - Trimerization domain of TRAF
  • 0.002763Inherited
    100895,48726
  • 100895 - Kazal-type serine protease inhibitors
  • 48726 - Immunoglobulin
  • 0.02847Inherited
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0.006108Inherited
    161093,161093
  • 161093 - MgtE membrane domain-like
  • 161093 - MgtE membrane domain-like
  • 0.008978Inherited
    57424,57362
  • 57424 - LDL receptor-like module
  • 57362 - BPTI-like
  • 0.001087Inherited
    49299,57362
  • 49299 - PKD domain
  • 57362 - BPTI-like
  • 0.006312Inherited
    54277,57889
  • 54277 - CAD & PB1 domains
  • 57889 - Cysteine-rich domain
  • 0.2519Inherited
    50249,57756
  • 50249 - Nucleic acid-binding proteins
  • 57756 - Retrovirus zinc finger-like domains
  • 0.001016Inherited
    50044,54277
  • 50044 - SH3-domain
  • 54277 - CAD & PB1 domains
  • 0.01554Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01832Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.2157Inherited
    56634,52317
  • 56634 - Heme-dependent catalase-like
  • 52317 - Class I glutamine amidotransferase-like
  • 0.02847Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.9948Inherited
    53448,50370
  • 53448 - Nucleotide-diphospho-sugar transferases
  • 50370 - Ricin B-like lectins
  • 1Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.5768Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.9659Inherited
    50729,81837
  • 50729 - PH domain-like
  • 81837 - BEACH domain
  • 0.1805Inherited
    89895,109728
  • 89895 - FYSH domain
  • 109728 - Hypothetical protein AF0491, middle domain
  • 0.4999Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.002389Inherited
    48371,50729
  • 48371 - ARM repeat
  • 50729 - PH domain-like
  • 0.02364Inherited
    103575,82895
  • 103575 - Plexin repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.2639Inherited
    56112,50978
  • 56112 - Protein kinase-like (PK-like)
  • 50978 - WD40 repeat-like
  • 0.02847Inherited
    52058,52540
  • 52058 - L domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04328Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2717Inherited
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0.06891Inherited
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.09441Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.09156Inherited
    47095,47095
  • 47095 - HMG-box
  • 47095 - HMG-box
  • 0.7935Inherited
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 1Inherited
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 1Inherited
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 1Inherited
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.1249Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 1Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 1Inherited
    57863,50729
  • 57863 - ArfGap/RecO-like zinc finger
  • 50729 - PH domain-like
  • 0.01757Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.006108Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 1Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.05413Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.8681Inherited
    49348,55711
  • 49348 - Clathrin adaptor appendage domain
  • 55711 - Subdomain of clathrin and coatomer appendage domain
  • 0.8677Inherited
    55550,52799
  • 55550 - SH2 domain
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.009597Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.3839Inherited
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0.01292Inherited
    50044,48065
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.3308Inherited
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0.6681Inherited
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0.04096Inherited
    109640,57667
  • 109640 - KRAB domain (Kruppel-associated box)
  • 57667 - beta-beta-alpha zinc fingers
  • 1Inherited
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00804Inherited
    57424,57196
  • 57424 - LDL receptor-like module
  • 57196 - EGF/Laminin
  • 0.1873Inherited
    48726,82895
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 0.3499Inherited
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0.9527Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 1Inherited
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0.9825Inherited
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.8604Inherited
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.007375Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.05604Inherited
    48452,57850
  • 48452 - TPR-like
  • 57850 - RING/U-box
  • 0.1975Inherited
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.005462Inherited
    53448,51161
  • 53448 - Nucleotide-diphospho-sugar transferases
  • 51161 - Trimeric LpxA-like enzymes
  • 0.6639Inherited
    90229,54928
  • 90229 - CCCH zinc finger
  • 54928 - RNA-binding domain, RBD
  • 0.7142Inherited
    63825,57184
  • 63825 - YWTD domain
  • 57184 - Growth factor receptor domain
  • 0.006358Inherited
    74924,54001
  • 74924 - Cap-Gly domain
  • 54001 - Cysteine proteinases
  • 0.1409Inherited
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0.2639Inherited
    52821,52799
  • 52821 - Rhodanese/Cell cycle control phosphatase
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.7223Inherited
    54171,82199
  • 54171 - DNA-binding domain
  • 82199 - SET domain
  • 0.2519Inherited
    48350,50729
  • 48350 - GTPase activation domain, GAP
  • 50729 - PH domain-like
  • 0.001294Inherited
    52172,109604
  • 52172 - CheY-like
  • 109604 - HD-domain/PDEase-like
  • 0.003673Inherited
    52172,46894
  • 52172 - CheY-like
  • 46894 - C-terminal effector domain of the bipartite response regulators
  • 0.01334Inherited
    52540,46689
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46689 - Homeodomain-like
  • 0.03093Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.7379Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 1Inherited
    46966,47473
  • 46966 - Spectrin repeat
  • 47473 - EF-hand
  • 1Inherited
    143503,54236
  • 143503 - PUG domain-like
  • 54236 - Ubiquitin-like
  • 0.00925Inherited
    81383,49785
  • 81383 - F-box domain
  • 49785 - Galactose-binding domain-like
  • 0.3152Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 1Inherited
    50891,48452
  • 50891 - Cyclophilin-like
  • 48452 - TPR-like
  • 0.009244Inherited
    81923,52540
  • 81923 - Double Clp-N motif
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.09347Inherited
    53756,56784
  • 53756 - UDP-Glycosyltransferase/glycogen phosphorylase
  • 56784 - HAD-like
  • 0.1821Inherited
    55666,46915
  • 55666 - Ribonuclease PH domain 2-like
  • 46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
  • 0.3942Inherited
    46915,54211
  • 46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.3942Inherited
    55666,54791
  • 55666 - Ribonuclease PH domain 2-like
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 0.761Inherited
    54791,50249
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 50249 - Nucleic acid-binding proteins
  • 0.761Inherited
    56112,55681
  • 56112 - Protein kinase-like (PK-like)
  • 55681 - Class II aaRS and biotin synthetases
  • 0.002389Inherited
    46458,63380
  • 46458 - Globin-like
  • 63380 - Riboflavin synthase domain-like
  • 0.001465Inherited
    56112,103243
  • 56112 - Protein kinase-like (PK-like)
  • 103243 - KA1-like
  • 0.01576Inherited
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0.02026Inherited
    49599,54695
  • 49599 - TRAF domain-like
  • 54695 - POZ domain
  • 0.08594Inherited
    51161,48371
  • 51161 - Trimeric LpxA-like enzymes
  • 48371 - ARM repeat
  • 0.003877Inherited
    57783,47954
  • 57783 - Zinc beta-ribbon
  • 47954 - Cyclin-like
  • 0.3609Inherited
    47576,143575
  • 47576 - Calponin-homology domain, CH-domain
  • 143575 - GAS2 domain-like
  • 0.03035Inherited
    81995,56112
  • 81995 - beta-sandwich domain of Sec23/24
  • 56112 - Protein kinase-like (PK-like)
  • 0.008978Inherited
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0.003746Inherited
    50044,56112
  • 50044 - SH3-domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.001465Inherited
    48350,55550
  • 48350 - GTPase activation domain, GAP
  • 55550 - SH2 domain
  • 0.06362Inherited
    50044,48350
  • 50044 - SH3-domain
  • 48350 - GTPase activation domain, GAP
  • 0.1262Inherited
    81901,81901
  • 81901 - HCP-like
  • 81901 - HCP-like
  • 0.03179Inherited
    54001,144232
  • 54001 - Cysteine proteinases
  • 144232 - HIT/MYND zinc finger-like
  • 0.001797Inherited
    49899,58006
  • 49899 - Concanavalin A-like lectins/glucanases
  • 58006 - Assembly domain of cartilage oligomeric matrix protein
  • 0.003673Inherited
    57196,103647
  • 57196 - EGF/Laminin
  • 103647 - TSP type-3 repeat
  • 0.01136Inherited
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.002563Inherited
    54211,56719
  • 54211 - Ribosomal protein S5 domain 2-like
  • 56719 - Type II DNA topoisomerase
  • 0.7991Inherited
    56112,48371
  • 56112 - Protein kinase-like (PK-like)
  • 48371 - ARM repeat
  • 0.01035Inherited
    81301,81271
  • 81301 - Nucleotidyltransferase
  • 81271 - TGS-like
  • 0.009597Inherited
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0.006781Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0914Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.03992Inherited
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0.03536Inherited
    46785,158702
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 0.04673Inherited
    158702,52540
  • 158702 - Sec63 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1126Inherited
    50249,46785
  • 50249 - Nucleic acid-binding proteins
  • 46785 - "Winged helix" DNA-binding domain
  • 0.007576Inherited
    55271,53150
  • 55271 - DNA repair protein MutS, domain I
  • 53150 - DNA repair protein MutS, domain II
  • 0.0109Inherited
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0.001431Inherited
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0.001431Inherited
    48452,48403
  • 48452 - TPR-like
  • 48403 - Ankyrin repeat
  • 0.004194Inherited
    57884,46689
  • 57884 - Ada DNA repair protein, N-terminal domain (N-Ada 10)
  • 46689 - Homeodomain-like
  • 0.006312Inherited
    49879,56784
  • 49879 - SMAD/FHA domain
  • 56784 - HAD-like
  • 0.02438Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.1612Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.01489Inherited
    51197,53335
  • 51197 - Clavaminate synthase-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0.002763Inherited
    57850,52540
  • 57850 - RING/U-box
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.007817Inherited
    52113,52540
  • 52113 - BRCT domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00925Inherited
    63570,56204
  • 63570 - PABC (PABP) domain
  • 56204 - Hect, E3 ligase catalytic domain
  • 0.00925Inherited
    54928,51197
  • 54928 - RNA-binding domain, RBD
  • 51197 - Clavaminate synthase-like
  • 0.01136Inherited
    48371,117839
  • 48371 - ARM repeat
  • 117839 - WWE domain
  • 0.1126Inherited
    52833,49785
  • 52833 - Thioredoxin-like
  • 49785 - Galactose-binding domain-like
  • 0.00452Inherited
    52833,47933
  • 52833 - Thioredoxin-like
  • 47933 - ERP29 C domain-like
  • 0.1249Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.2549Inherited
    56112,48452
  • 56112 - Protein kinase-like (PK-like)
  • 48452 - TPR-like
  • 0.06555Inherited
    52058,56112
  • 52058 - L domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.3692Inherited
    56112,47473
  • 56112 - Protein kinase-like (PK-like)
  • 47473 - EF-hand
  • 0.4575Inherited
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0.6221Inherited
    54236,50729
  • 54236 - Ubiquitin-like
  • 50729 - PH domain-like
  • 0.03592Inherited
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 1Inherited
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 1Inherited
    52540,158235
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 158235 - SOCS box-like
  • 0.00925Inherited
    50249,116742
  • 50249 - Nucleic acid-binding proteins
  • 116742 - eIF2alpha middle domain-like
  • 0.5716Inherited
    116742,110993
  • 116742 - eIF2alpha middle domain-like
  • 110993 - eIF-2-alpha, C-terminal domain
  • 0.5716Inherited
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 1Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 1Inherited
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 1Inherited
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 1Inherited
    46565,158702
  • 46565 - Chaperone J-domain
  • 158702 - Sec63 N-terminal domain-like
  • 0.1048Inherited
    49899,63887
  • 49899 - Concanavalin A-like lectins/glucanases
  • 63887 - P-domain of calnexin/calreticulin
  • 0.5612Inherited
    54236,54001
  • 54236 - Ubiquitin-like
  • 54001 - Cysteine proteinases
  • 0.009597Inherited
    48452,46565
  • 48452 - TPR-like
  • 46565 - Chaperone J-domain
  • 0.08021Inherited
    68906,57850
  • 68906 - SAP domain
  • 57850 - RING/U-box
  • 0.01295Inherited
    49854,49899
  • 49854 - Spermadhesin, CUB domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00452Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 1Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.9104Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 1Inherited
    57581,57581
  • 57581 - TB module/8-cys domain
  • 57581 - TB module/8-cys domain
  • 0.0817Inherited
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 1Inherited
    47336,52777
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 0.79Inherited
    52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.8749Inherited
    56801,47336
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 1Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 1Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.5011Inherited
    46565,57938
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 0.3818Inherited
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.4856Inherited
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.5869Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.3815Inherited
    48403,82199
  • 48403 - Ankyrin repeat
  • 82199 - SET domain
  • 0.005462Inherited
    54171,54171
  • 54171 - DNA-binding domain
  • 54171 - DNA-binding domain
  • 0.2639Inherited
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0.2838Inherited
    56235,52402
  • 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases)
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 0.7066Inherited
    109604,81301
  • 109604 - HD-domain/PDEase-like
  • 81301 - Nucleotidyltransferase
  • 0.03357Inherited
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0.5063Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.007598Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.07457Inherited
    48726,57424
  • 48726 - Immunoglobulin
  • 57424 - LDL receptor-like module
  • 0.4321Inherited
    57424,48726
  • 57424 - LDL receptor-like module
  • 48726 - Immunoglobulin
  • 0.7988Inherited
    81296,101898
  • 81296 - E set domains
  • 101898 - NHL repeat
  • 0.0067Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 1Inherited
    51445,51445
  • 51445 - (Trans)glycosidases
  • 51445 - (Trans)glycosidases
  • 0.01136Inherited
    48371,52540
  • 48371 - ARM repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2359Inherited
    48097,56112
  • 48097 - Regulator of G-protein signaling, RGS
  • 56112 - Protein kinase-like (PK-like)
  • 0.004722Inherited
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 1Inherited
    57196,50242
  • 57196 - EGF/Laminin
  • 50242 - TIMP-like
  • 0.2952Inherited
    48350,50044
  • 48350 - GTPase activation domain, GAP
  • 50044 - SH3-domain
  • 0.1409Inherited
    52087,48350
  • 52087 - CRAL/TRIO domain
  • 48350 - GTPase activation domain, GAP
  • 0.006312Inherited
    64268,50729
  • 64268 - PX domain
  • 50729 - PH domain-like
  • 0.09347Inherited
    56512,52218
  • 56512 - Nitric oxide (NO) synthase oxygenase domain
  • 52218 - Flavoproteins
  • 0.04544Inherited
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.0351Inherited
    57850,57933
  • 57850 - RING/U-box
  • 57933 - TAZ domain
  • 0.005462Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 1Inherited
    48403,158235
  • 48403 - Ankyrin repeat
  • 158235 - SOCS box-like
  • 0.6156Inherited
    54236,57829
  • 54236 - Ubiquitin-like
  • 57829 - Zn-binding ribosomal proteins
  • 0.1969Inherited
    51045,56204
  • 51045 - WW domain
  • 56204 - Hect, E3 ligase catalytic domain
  • 0.887Inherited
    64268,103657
  • 64268 - PX domain
  • 103657 - BAR/IMD domain-like
  • 0.9753Inherited
    81321,81321
  • 81321 - Family A G protein-coupled receptor-like
  • 81321 - Family A G protein-coupled receptor-like
  • 0.001517Inherited
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0.3794Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 1Inherited
    57535,53822
  • 57535 - Complement control module/SCR domain
  • 53822 - Periplasmic binding protein-like I
  • 0.07145Inherited
    49562,54236
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 54236 - Ubiquitin-like
  • 0.1903Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.9129Inherited
    52047,52058
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 0.05562Inherited
    46955,63763
  • 46955 - Putative DNA-binding domain
  • 63763 - SAND domain-like
  • 1Inherited
    49854,49854
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 1Inherited
    49785,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.7639Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 1Inherited
    49854,49785
  • 49854 - Spermadhesin, CUB domain
  • 49785 - Galactose-binding domain-like
  • 0.7611Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.1719Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.121Inherited
    48350,55961
  • 48350 - GTPase activation domain, GAP
  • 55961 - Bet v1-like
  • 0.05577Inherited
    48726,57196
  • 48726 - Immunoglobulin
  • 57196 - EGF/Laminin
  • 0.01111Inherited
    56112,52799
  • 56112 - Protein kinase-like (PK-like)
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.01136Inherited
    117839,117839
  • 117839 - WWE domain
  • 117839 - WWE domain
  • 0.04982Inherited
    159034,57850
  • 159034 - Mib/herc2 domain-like
  • 57850 - RING/U-box
  • 0.1903Inherited
    57850,159034
  • 57850 - RING/U-box
  • 159034 - Mib/herc2 domain-like
  • 0.1903Inherited
    47370,47370
  • 47370 - Bromodomain
  • 47370 - Bromodomain
  • 0.08007Inherited
    55785,55781
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55781 - GAF domain-like
  • 0.006312Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.01301Inherited
    50729,47031
  • 50729 - PH domain-like
  • 47031 - Second domain of FERM
  • 0.002763Inherited
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0.001801Inherited
    63877,81321
  • 63877 - Methuselah ectodomain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.01136Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.007348Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.01693Inherited
    55781,55785
  • 55781 - GAF domain-like
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0109Inherited
    50729,46785
  • 50729 - PH domain-like
  • 46785 - "Winged helix" DNA-binding domain
  • 0.001465Inherited
    54277,56112
  • 54277 - CAD & PB1 domains
  • 56112 - Protein kinase-like (PK-like)
  • 0.001797Inherited
    52087,46966
  • 52087 - CRAL/TRIO domain
  • 46966 - Spectrin repeat
  • 0.003673Inherited
    46785,50156
  • 46785 - "Winged helix" DNA-binding domain
  • 50156 - PDZ domain-like
  • 0.003877Inherited
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 1Inherited
    158702,81296
  • 158702 - Sec63 N-terminal domain-like
  • 81296 - E set domains
  • 0.3152Inherited
    140383,140383
  • 140383 - BSD domain-like
  • 140383 - BSD domain-like
  • 0.003877Inherited
    50729,140383
  • 50729 - PH domain-like
  • 140383 - BSD domain-like
  • 0.003877Inherited
    54236,46934
  • 54236 - Ubiquitin-like
  • 46934 - UBA-like
  • 0.002763Inherited
    50729,48371
  • 50729 - PH domain-like
  • 48371 - ARM repeat
  • 0.03869Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 1Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.4902Inherited
    50022,55961
  • 50022 - ISP domain
  • 55961 - Bet v1-like
  • 0.6855Inherited
    54534,48452
  • 54534 - FKBP-like
  • 48452 - TPR-like
  • 0.5231Inherited
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 1Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.02174Inherited
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0.8741Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 1Inherited
    49599,54001
  • 49599 - TRAF domain-like
  • 54001 - Cysteine proteinases
  • 0.8573Inherited
    56024,56024
  • 56024 - Phospholipase D/nuclease
  • 56024 - Phospholipase D/nuclease
  • 0.5385Inherited
    57889,49562
  • 57889 - Cysteine-rich domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.1088Inherited
    57567,57567
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 0.01529Inherited
    57567,57603
  • 57567 - Serine protease inhibitors
  • 57603 - FnI-like domain
  • 0.1409Inherited
    47986,52200
  • 47986 - DEATH domain
  • 52200 - Toll/Interleukin receptor TIR domain
  • 0.1058Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.06847Inherited
    55785,55073
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55073 - Nucleotide cyclase
  • 0.1266Inherited

    (show details)