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Biological Process (BP): negative regulation of nervous system development

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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   biological_process [GO:0008150] <24>
+ + + + 4:   biological regulation [GO:0065007] <5>(165|190) (757|933|542)
+ + + 3:   regulation of biological process [GO:0050789] <34>(155|176) (709|883|505)
+ + 2:   negative regulation of biological process [GO:0048519] <52>(72|76) (445|449|253)
+ + 2:   regulation of developmental process [GO:0050793] <28>(34|33) (298|322|199)
+ + 2:   regulation of multicellular organismal development [GO:2000026] <72>(28|28) (253|276|169)
+ + 2:   regulation of multicellular organismal process [GO:0051239] <48>(40|41) (340|360|224)
+ 1:   negative regulation of developmental process [GO:0051093] <84>(8|7) (150|118|68)
+ 1:   negative regulation of multicellular organismal process [GO:0051241] <147>(14|12) (183|136|79)
+ 1:   regulation of nervous system development [GO:0051960] <13>(11|8) (152|178|103)
0:   negative regulation of nervous system development [GO:0051961] <13>(3|2) (74|60|35)
- 1:   negative regulation of neurogenesis [GO:0050768] <7>(3|2) (64|51|32)
- 1:   negative regulation of synapse assembly [GO:0051964] <4>(0|0) (17|9|2)
- 1:   negative regulation of anterior neural cell fate commitment of the neural plate [GO:0022001] <2>(0|0) (0|0|0)
- 1:   negative regulation of cerebellar granule cell precursor proliferation [GO:0021941] <1>(0|0) (0|0|0)
- 1:   negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021914] <1>(0|0) (0|0|0)
- 1:   negative regulation of branching morphogenesis of a nerve [GO:2000173](0|0) (0|0|0)
- 1:   negative regulation of cell proliferation in midbrain [GO:1904934](0|0) (0|0|0)
- 1:   negative regulation of convergent extension involved in rhombomere morphogenesis [GO:1904134](0|0) (0|0|0)
- 1:   negative regulation of myelination [GO:0031642](0|0) (1|0|0)
- 1:   negative regulation of optic nerve formation [GO:2000596](0|0) (0|0|0)
- 1:   negative regulation of planar cell polarity pathway involved in neural tube closure [GO:2000168](0|0) (0|0|0)
- 1:   negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patternin [GO:1901621](0|0) (1|0|0)
- 1:   negative regulation of synapse maturation [GO:2000297](0|0) (2|1|0)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
HLH, helix-loop-helix DNA-binding domain0.0000086930.0000001231Direct
Metallothionein0.000000000000024880.000000001125Direct
Immunoglobulin0.000000000016770.1352Inherited


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
HLH, helix-loop-helix DNA-binding domain0.0000031960.0000002322Direct
Metallothionein0.000000000000033180.000000004294Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this GO term
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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
HR1 repeat0Direct
BAR/IMD domain-like0.000000000002425Direct
Composite domain of metallo-dependent hydrolases0.00000000002375Direct
Metallothionein0.0000000006616Direct
EGF/Laminin0.0000000007138Direct
HLH, helix-loop-helix DNA-binding domain0.00000007663Direct
RUN domain-like0.0000001012Direct
Growth factor receptor domain0.000000266Direct
Metallo-dependent hydrolases0.0000005271Direct
Notch domain0.000003286Direct
F-box domain0.000005675Direct
YWTD domain0.00001241Direct
Kazal-type serine protease inhibitors0.00001847Direct
FAT domain of focal adhesion kinase0.00004563Direct
Rap/Ran-GAP0.00006328Direct
SAM/Pointed domain0.0001299Direct
Concanavalin A-like lectins/glucanases0.0001511Direct
DBL homology domain (DH-domain)0.0001564Direct
LDL receptor-like module0.0001752Direct
PH domain-like0.0002216Direct
TAFH domain-like0.0003447Direct
Fibrinogen C-terminal domain-like0.0009483Direct
FnI-like domain0.4833Inherited
SMAD/FHA domain0.3042Inherited
Homeodomain-like0.2163Inherited
lambda repressor-like DNA-binding domains0.7774Inherited
RING/U-box0.2001Inherited
Plexin repeat0.005376Inherited
Sema domain0.02244Inherited
Family A G protein-coupled receptor-like1Inherited
RNA-binding domain, RBD0.00647Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2338Inherited
L domain-like0.01338Inherited
Fibronectin type III0.4274Inherited
Galactose-binding domain-like0.009642Inherited
Immunoglobulin0.1082Inherited
(Phosphotyrosine protein) phosphatases II0.01664Inherited
alpha/beta-Hydrolases1Inherited
HMG-box0.01082Inherited
SH3-domain0.001543Inherited
CRAL/TRIO domain0.009069Inherited
Second domain of FERM0.01366Inherited
ARM repeat0.1636Inherited
Acetyl-CoA synthetase-like0.204Inherited
Quinoprotein alcohol dehydrogenase-like0.0203Inherited
Ras GEF0.08241Inherited
cAMP-binding domain-like0.155Inherited
PDZ domain-like0.5498Inherited
Ubiquitin-like0.2125Inherited
Ankyrin repeat0.2219Inherited
Cupredoxins0.001286Inherited
Kringle-like0.5937Inherited
FAD/NAD(P)-binding domain0.7101Inherited
TSP-1 type 1 repeat0.9048Inherited
GTPase activation domain, GAP0.004985Inherited
SOCS box-like0.001547Inherited
Protein kinase-like (PK-like)0.8412Inherited
Cytokine0.7359Inherited
p53-like transcription factors0.85Inherited
vWA-like0.3176Inherited
Orange domain-like0.001187Inherited
SH2 domain0.8912Inherited
Thyroglobulin type-1 domain0.00137Inherited
Trypsin-like serine proteases1Inherited
E set domains0.2255Inherited
DHS-like NAD/FAD-binding domain0.008583Inherited
RNase III domain-like0.003736Inherited
dsRNA-binding domain-like0.1203Inherited
Cystine-knot cytokines1Inherited
Arginase/deacetylase0.02945Inherited
MHC antigen-recognition domain0.00811Inherited
Carbonic anhydrase0.00433Inherited
FKBP-like0.005259Inherited
BRCT domain0.06361Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81383,49899
  • 81383 - F-box domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    47473,57610
  • 47473 - EF-hand
  • 57610 - Thyroglobulin type-1 domain
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0.0000000000195Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0.0000000000195Direct
    48350,50044
  • 48350 - GTPase activation domain, GAP
  • 50044 - SH3-domain
  • 0.00000000002476Direct
    52058,57196
  • 52058 - L domain-like
  • 57196 - EGF/Laminin
  • 0.0000000000464Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0000000002052Direct
    56112,50998
  • 56112 - Protein kinase-like (PK-like)
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 0.000000005339Direct
    100895,47473
  • 100895 - Kazal-type serine protease inhibitors
  • 47473 - EF-hand
  • 0.0000000164Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0.00000006585Direct
    49723,140741
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 140741 - RUN domain-like
  • 0.00000006897Direct
    48726,57196
  • 48726 - Immunoglobulin
  • 57196 - EGF/Laminin
  • 0.00000008726Direct
    140741,49723
  • 140741 - RUN domain-like
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.0000001527Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.0000002257Direct
    48371,48350
  • 48371 - ARM repeat
  • 48350 - GTPase activation domain, GAP
  • 0.0000004619Direct
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.0000004619Direct
    103575,82895
  • 103575 - Plexin repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000005066Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0000005755Direct
    49265,56496
  • 49265 - Fibronectin type III
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.0000007136Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0000007136Direct
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.0000008862Direct
    54534,48452
  • 54534 - FKBP-like
  • 48452 - TPR-like
  • 0.000001011Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.000003286Direct
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.000003444Direct
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.00002695Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.00004563Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.0001194Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0001811Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0001822Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0.0002852Direct
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.0003165Direct
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.0007044Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0007831Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0009483Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.0009483Direct
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.2707Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.01426Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2781Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9454Inherited
    52799,52799
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.1179Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 1Inherited
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.00738Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.002405Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.00361Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.06071Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.5056Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.8073Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.06329Inherited
    50729,50044
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.08262Inherited
    54236,48366
  • 54236 - Ubiquitin-like
  • 48366 - Ras GEF
  • 0.01543Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.6349Inherited
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.7359Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.7108Inherited
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.1831Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.001187Inherited
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.005257Inherited
    69065,54768
  • 69065 - RNase III domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.001769Inherited
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0.001571Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00431Inherited
    51069,49265
  • 51069 - Carbonic anhydrase
  • 49265 - Fibronectin type III
  • 0.00433Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    100895,47473,57610
  • 100895 - Kazal-type serine protease inhibitors
  • 47473 - EF-hand
  • 57610 - Thyroglobulin type-1 domain
  • 0Direct
    49265,49265,56496
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.0000000000001038Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0000000000002668Direct
    51338,51556,51338
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0.0000000000195Direct
    52058,57196,57196
  • 52058 - L domain-like
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0000000000464Direct
    54534,54534,48452
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 48452 - TPR-like
  • 0.000000008755Direct
    52058,52058,57196
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 57196 - EGF/Laminin
  • 0.00000006897Direct
    140741,49723,140741
  • 140741 - RUN domain-like
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 140741 - RUN domain-like
  • 0.00000006897Direct
    90193,90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.00000008726Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.0000004619Direct
    57184,49899,57196
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.0000004619Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0000004619Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.0000004619Direct
    101912,103575,82895
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000005066Direct
    103575,82895,82895
  • 103575 - Plexin repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.0000005066Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.0000007136Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000001221Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.000002433Direct
    57196,57184,49899
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000003286Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.000007796Direct
    49562,49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.000009627Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.00001977Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.00002695Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0000921Direct
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0001752Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.0001822Direct
    57196,57196,49899
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0003447Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0004339Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.0005535Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6121Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 1Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.4594Inherited
    48065,50729,50044
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.06071Inherited
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.3602Inherited
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.005257Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
    Plot tree as:   Download Newick format tree:   Browsing in Tree_gateway:
    (show help)