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Biological Process (BP): cellular response to organic substance

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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   biological_process [GO:0008150] <24>
+ + + 3:   cellular process [GO:0009987] <21>(372|486) (1162|1371|744)
+ + + 3:   response to stimulus [GO:0050896] <16>(133|153) (688|755|432)
+ + 2:   cellular response to stimulus [GO:0051716] <12>(88|98) (521|550|312)
+ + 2:   response to chemical [GO:0042221] <38>(71|82) (484|441|237)
+ 1:   cellular response to chemical stimulus [GO:0070887] <34>(47|54) (352|295|150)
+ 1:   response to organic substance [GO:0010033] <59>(43|45) (353|295|151)
0:   cellular response to organic substance [GO:0071310] <25>(30|31) (269|220|113)
- 1:   cellular response to organic cyclic compound [GO:0071407] <96>(8|7) (92|46|19)
- 1:   cellular response to organonitrogen compound [GO:0071417] <61>(8|7) (95|64|25)
- 1:   cellular response to lipid [GO:0071396] <32>(14|13) (77|35|15)
- 1:   cellular response to cytokine stimulus [GO:0071345] <29>(7|10) (78|69|38)
- 1:   cellular response to alcohol [GO:0097306] <19>(2|2) (32|9|0)
- 1:   cellular response to hormone stimulus [GO:0032870] <15>(15|15) (102|60|27)
- 1:   cellular response to growth factor stimulus [GO:0071363] <10>(4|3) (72|69|49)
- 1:   cellular response to carbohydrate stimulus [GO:0071322] <6>(2|1) (33|19|11)
- 1:   cellular response to pheromone [GO:0071444] <3>(0|0) (9|3|1)
- 1:   cellular response to topologically incorrect protein [GO:0035967] <2>(1|1) (29|15|6)
- 1:   cellular response to menadione [GO:0036245] <1>(0|0) (5|2|0)
- 1:   cellular response to methylglyoxal [GO:0097238] <1>(0|0) (0|0|0)
- 1:   cellular response to GW 7647 [GO:0072760](0|0) (0|0|0)
- 1:   cellular response to Gentian violet [GO:0072729](0|0) (0|0|0)
- 1:   cellular response to N-acetyl-D-glucosamine [GO:0097316](0|0) (0|0|0)
- 1:   cellular response to acetate [GO:0071311](0|0) (1|0|0)
- 1:   cellular response to dithiothreitol [GO:0072721](0|0) (0|0|0)
- 1:   cellular response to glyoxal [GO:0036471](0|0) (1|0|0)
- 1:   cellular response to menaquinone [GO:0071308](0|0) (0|0|0)
- 1:   cellular response to methyl methanesulfonate [GO:0072703](0|0) (0|0|0)
- 1:   cellular response to methylmercury [GO:0071406](0|0) (0|0|0)
- 1:   cellular response to molecule of oomycetes origin [GO:0071227](0|0) (0|0|0)
- 1:   cellular response to paraquat [GO:0072756](0|0) (0|0|0)
- 1:   cellular response to sodium dodecyl sulfate [GO:0072707](0|0) (1|1|1)
- 1:   cellular response to t-BOOH [GO:0072736](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Cytokine0.00000059610.000000000864Direct
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain00Direct
Roadblock/LC7 domain00Direct
Stathmin0.0000054750.0005669Direct
EF-hand0.12780.06792Inherited
Carbonic anhydrase0.23760.8063Inherited
Bet v1-like0.0045450.4704Inherited
Cysteine proteinases11Inherited
NAD(P)-linked oxidoreductase0.11210.5538Inherited
Mitochondrial carrier0.0028970.5979Inherited
Cytochrome P4500.00075141Inherited
Lipocalins0.2510.9026Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.76751Inherited
Annexin0.0016340.06898Inherited
Transducin (heterotrimeric G protein), gamma chain0.03640.1473Inherited
(Trans)glycosidases0.00027160.00575Inherited
Family A G protein-coupled receptor-like0.9781Inherited
Acyl-CoA N-acyltransferases (Nat)0.00021860.7801Inherited
Aquaporin-like0.36890.8815Inherited
Caspase-like0.00021520.005541Inherited
Cystine-knot cytokines0.0045450Inherited
14-3-3 protein0.032340.1473Inherited
UBC-like0.039490.00678Inherited
Interleukin 8-like chemokines0.0023230.3979Inherited
4-helical cytokines0.036860.4827Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0069140.3669Inherited
Metallothionein11Inherited
alpha/beta-Hydrolases11Inherited
Histidine-containing phosphotransfer domain, HPT domain0.0000098720.003347Inherited
Insulin-like0.70311Inherited


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Family

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Bee venom hyaluronidase00Direct
Fibroblast growth factors (FGF)0.00000014340.0000000000004548Direct
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain00Direct
Interleukin 17F, IL-17F0.000000000014940.00000000009551Direct
Roadblock/LC7 domain00Direct
Short-chain cytokines0.0000033350.000004141Direct
Stathmin0.0000094870.0009481Direct
Carbonic anhydrase0.23120.786Inherited
UDPGT-like0.4950.9384Inherited
Papain-like0.97621Inherited
Aldo-keto reductases (NADP)0.11240.7317Inherited
Mitochondrial carrier0.0069020.7132Inherited
Rhodopsin-like0.0025560.6321Inherited
Cytochrome P4500.00079541Inherited
Retinol binding protein-like0.057070.4811Inherited
Annexin0.0016560.07249Inherited
Transducin (heterotrimeric G protein), gamma chain0.035270.1468Inherited
G proteins0.000072850.06012Inherited
N-acetyl transferase, NAT0.000002870.01102Inherited
Aquaporin-like0.3630.8646Inherited
Caspase catalytic domain0.00021340.002878Inherited
14-3-3 protein0.031050.1468Inherited
UBC-related0.039330.9529Inherited
Interferons/interleukin-10 (IL-10)0.15690.8965Inherited
Interleukin 8-like chemokines0.0027950.4477Inherited
Long-chain cytokines0.85171Inherited
Proteasome subunits0.0027880.2564Inherited
Metallothionein11Inherited
Carboxylesterase0.060350.5743Inherited
Phosphorelay protein-like0.00000075740.01272Inherited
Insulin-like0.68291Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this GO term
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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Roadblock/LC7 domain0Direct
Cystine-knot cytokines0Direct
Protein kinase-like (PK-like)0Direct
RNase III domain-like0Direct
MHC antigen-recognition domain0Direct
Snake toxin-like0Direct
Transcription factor STAT-4 N-domain0Direct
SMAD/FHA domain0Direct
STAT0Direct
SH2 domain0Direct
SMAD MH1 domain0Direct
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain0Direct
p53-like transcription factors0.000000000000001898Direct
dsRNA-binding domain-like0.00000000000000466Direct
PAZ domain0.000000000000374Direct
Immunoglobulin0.000000000003777Direct
Spermadhesin, CUB domain0.0000000002077Direct
Cytokine0.0000000005062Direct
HIN-2000 domain-like0.000000002166Direct
Trimerization domain of TRAF0.0000002272Direct
Chitinase insertion domain0.00000115Direct
TNF-like0.00001462Direct
ABC transporter transmembrane region0.0000168Direct
Heparin-binding domain from vascular endothelial growth factor0.000022Direct
Second domain of FERM0.00002323Direct
EGF/Laminin0.00003594Direct
L domain-like0.00003852Direct
TNF receptor-like0.00004269Direct
GAS2 domain-like0.00004887Direct
DNA-binding domain of EIN3-like0.00006467Direct
Kelch motif0.00008254Direct
RNI-like0.0001084Direct
HD-domain/PDEase-like0.0001213Direct
Moesin tail domain0.0001641Direct
Nuclear receptor ligand-binding domain0.0002145Direct
Stathmin0.0003993Direct
DEATH domain0.0004023Direct
C-terminal domain of ProRS0.0009976Direct
ARID-like0.07563Inherited
Spectrin repeat0.9562Inherited
Mitochondrial carrier0.5142Inherited
vWA-like0.959Inherited
ArfGap/RecO-like zinc finger0.3199Inherited
ACT-like1Inherited
Arginase/deacetylase0.01721Inherited
Rap/Ran-GAP0.2854Inherited
DBL homology domain (DH-domain)0.6368Inherited
Integrin alpha N-terminal domain0.1243Inherited
DNase I-like0.4002Inherited
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0.3886Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.01475Inherited
alpha-ketoacid dehydrogenase kinase, N-terminal domain0.01784Inherited
(Phosphotyrosine protein) phosphatases II0.2396Inherited
Fibronectin type III1Inherited
Carbonic anhydrase0.7097Inherited
SH3-domain0.00126Inherited
Transducin (heterotrimeric G protein), gamma chain0.1182Inherited
Phospholipase A2, PLA20.1706Inherited
Insulin-like1Inherited
Tetraspanin1Inherited
LuxS/MPP-like metallohydrolase0.5635Inherited
KA1-like0.8596Inherited
Bet v1-like0.3986Inherited
Neurotransmitter-gated ion-channel transmembrane pore1Inherited
Nicotinic receptor ligand binding domain-like1Inherited
Chlorophyll a-b binding protein0.3753Inherited
SET domain1Inherited
HRDC-like0.3182Inherited
Calponin-homology domain, CH-domain0.4649Inherited
Class II aaRS and biotin synthetases1Inherited
Caspase-like0.004077Inherited
FnI-like domain0.002984Inherited
BPTI-like0.04848Inherited
Formin homology 2 domain (FH2 domain)1Inherited
ARM repeat1Inherited
TB module/8-cys domain0.001225Inherited
SAND domain-like0.3978Inherited
Aquaporin-like0.7833Inherited
SAM/Pointed domain0.4965Inherited
Transducin (alpha subunit), insertion domain1Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.8275Inherited
Calcium ATPase, transduction domain A0.9321Inherited
Acid proteases1Inherited
Calcium ATPase, transmembrane domain M1Inherited
HAD-like1Inherited
Periplasmic binding protein-like II0.3654Inherited
Periplasmic binding protein-like I0.01513Inherited
AhpD-like0.1229Inherited
Calpain large subunit, middle domain (domain III)0.2424Inherited
Amyloid beta a4 protein copper binding domain (domain 2)0.05136Inherited
A heparin-binding domain0.0709Inherited
CAPPD, an extracellular domain of amyloid beta A4 protein0.09361Inherited
Nudix1Inherited
GAF domain-like0.00182Inherited
Amine oxidase catalytic domain0.007759Inherited
Amine oxidase N-terminal region0.007759Inherited
CalX-like0.2694Inherited
Nucleotide cyclase0.494Inherited
SpoIIaa-like0.2592Inherited
Acyl-CoA N-acyltransferases (Nat)0.6846Inherited
UBC-like0.004998Inherited
cAMP-binding domain-like0.1559Inherited
C-terminal domain of Ku800.2463Inherited
SPOC domain-like0.2463Inherited
Bactericidal permeability-increasing protein, BPI0.02534Inherited
Defensin-like0.1184Inherited
Lipocalins0.8043Inherited
WRKY DNA-binding domain1Inherited
HLH, helix-loop-helix DNA-binding domain1Inherited
lambda repressor-like DNA-binding domains0.5181Inherited
CCCH zinc finger0.004353Inherited
Annexin0.05405Inherited
UDP-Glycosyltransferase/glycogen phosphorylase1Inherited
NAD(P)-linked oxidoreductase0.4738Inherited
beta-beta-alpha zinc fingers0.1784Inherited
SAP domain0.2856Inherited
Prefoldin0.5331Inherited
POZ domain0.9893Inherited
Hormone receptor domain0.01902Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.02972Inherited
Family A G protein-coupled receptor-like1Inherited
Galactose-binding domain-like1Inherited
DNA-binding domain0.2381Inherited
Homeodomain-like1Inherited
14-3-3 protein0.1182Inherited
TPR-like1Inherited
F-box domain0.9716Inherited
NAC domain1Inherited
HMG-box1Inherited
Actin depolymerizing proteins0.2276Inherited
C-terminal, gelsolin-like domain of Sec23/240.2861Inherited
VHP, Villin headpiece domain0.002439Inherited
PLC-like phosphodiesterases0.8257Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.8441Inherited
Translation proteins1Inherited
TSP type-3 repeat0.2105Inherited
P-loop containing nucleoside triphosphate hydrolases0.4206Inherited
Retrovirus zinc finger-like domains0.0417Inherited
Nucleoplasmin-like core domain0.01402Inherited
Ribonuclease H-like0.1494Inherited
RNA-binding domain, RBD0.01196Inherited
Nucleic acid-binding proteins1Inherited
PAP/OAS1 substrate-binding domain0.001676Inherited
Nucleotidyltransferase0.2661Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.1954Inherited
Inhibitor of apoptosis (IAP) repeat0.6432Inherited
AN1-like Zinc finger0.2694Inherited
TSP-1 type 1 repeat0.4922Inherited
(Trans)glycosidases0.004233Inherited
PGBD-like0.9571Inherited
Hemopexin-like domain0.9892Inherited
NAP-like0.007221Inherited
EF-G C-terminal domain-like0.7468Inherited
Complement control module/SCR domain1Inherited
Composite domain of metallo-dependent hydrolases0.009321Inherited
Fibrinogen coiled-coil and central regions0.01101Inherited
Metallo-dependent hydrolases0.9708Inherited
Cytochrome P4501Inherited
Thiolase-like0.9871Inherited
FabD/lysophospholipase-like0.9987Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
PreATP-grasp domain1Inherited
ClpP/crotonase1Inherited
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.4124Inherited
Rudiment single hybrid motif1Inherited
ACP-like1Inherited
PDZ domain-like0.9574Inherited
BAR/IMD domain-like0.1861Inherited
Voltage-gated potassium channels1Inherited
SRF-like0.1158Inherited
Eferin C-derminal domain-like0.01566Inherited
Growth factor receptor domain0.4453Inherited
GLA-domain0.00637Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Single hybrid motif1Inherited
PEP carboxykinase N-terminal domain0.1564Inherited
PEP carboxykinase-like0.2694Inherited
MFS general substrate transporter1Inherited
GroES-like1Inherited
E set domains0.7721Inherited
Cyclin-like1Inherited
Rad51 N-terminal domain-like0.1808Inherited
MIR domain0.006435Inherited
IP3 receptor type 1 binding core, domain 20.005628Inherited
Concanavalin A-like lectins/glucanases0.06078Inherited
EF-hand0.05318Inherited
Ankyrin repeat0.8849Inherited
Frizzled cysteine-rich domain0.05907Inherited
Fibrinogen C-terminal domain-like0.3231Inherited
Metalloproteases ("zincins"), catalytic domain0.09676Inherited
ClpS-like0.1229Inherited
Kringle-like0.5768Inherited
Cullin repeat-like0.1661Inherited
Cdc48 domain 2-like0.9233Inherited
ADC-like0.9233Inherited
RmlC-like cupins1Inherited
Toll/Interleukin receptor TIR domain1Inherited
Interleukin 8-like chemokines0.3341Inherited
FAT domain of focal adhesion kinase0.0191Inherited
SOCS box-like0.07279Inherited
4-helical cytokines0.4097Inherited
RING/U-box0.2793Inherited
B-box zinc-binding domain0.3867Inherited
"Winged helix" DNA-binding domain0.1359Inherited
DnaJ/Hsp40 cysteine-rich domain0.7985Inherited
HSP40/DnaJ peptide-binding domain0.9Inherited
Cystatin/monellin0.5181Inherited
Nuclear receptor coactivator interlocking domain0.07563Inherited
Ras GEF0.005628Inherited
WW domain0.2412Inherited
Bromodomain0.2174Inherited
Class I glutamine amidotransferase-like1Inherited
Clavaminate synthase-like1Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.05032Inherited
Riboflavin synthase domain-like0.109Inherited
mRNA decapping enzyme DcpS N-terminal domain0.0191Inherited
HIT-like0.5071Inherited
Flavoproteins1Inherited
Cullin homology domain0.0135Inherited
Lipoxigenase0.6045Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)1Inherited
Cysteine-rich domain0.03187Inherited
GTPase activation domain, GAP0.1856Inherited
PH domain-like0.007055Inherited
Notch domain0.05136Inherited
Thioredoxin-like1Inherited
DHS-like NAD/FAD-binding domain0.6723Inherited
FYVE/PHD zinc finger1Inherited
Glycerol-3-phosphate (1)-acyltransferase0.9117Inherited
A DNA-binding domain in eukaryotic transcription factors0.7583Inherited
Leucine zipper domain0.01257Inherited
Quinoprotein alcohol dehydrogenase-like0.02503Inherited
PapD-like0.03499Inherited
P-domain of calnexin/calreticulin0.139Inherited
PA domain0.77Inherited
Seven-hairpin glycosidases1Inherited
Sec63 N-terminal domain-like0.2548Inherited
Subtilisin-like0.498Inherited
Ribosomal protein S5 domain 2-like0.9825Inherited
HSP90 C-terminal domain1Inherited
Metallothionein1Inherited
TRAF domain-like0.151Inherited
CAD & PB1 domains1Inherited
Rhomboid-like0.0682Inherited
Actin-like ATPase domain1Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain1Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain1Inherited
Chaperone J-domain0.9131Inherited
Cysteine proteinases1Inherited
Hect, E3 ligase catalytic domain0.06008Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3068Inherited
Heme-dependent peroxidases0.3311Inherited
Histone-fold1Inherited
alpha/beta-Hydrolases1Inherited
PP2C-like1Inherited
Homodimeric domain of signal transducing histidine kinase0.002039Inherited
CheY-like0.0193Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2784Inherited
Histidine-containing phosphotransfer domain, HPT domain0.002439Inherited
NHL repeat0.03499Inherited
LDL receptor-like module0.1684Inherited
Pectin lyase-like1Inherited
Integrin domains0.8649Inherited
Plexin repeat0.9405Inherited
DUSP-like0.01555Inherited
EPT/RTPC-like0.06363Inherited
Integrin beta tail domain0.8419Inherited
Zn2/Cys6 DNA-binding domain1Inherited
Ubiquitin-like0.09211Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50998,56112
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54001,55205
  • 54001 - Cysteine proteinases
  • 55205 - EPT/RTPC-like
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    54495,54211
  • 54495 - UBC-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0Direct
    69065,54768
  • 69065 - RNase III domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    143791,54236
  • 143791 - DUSP-like
  • 54236 - Ubiquitin-like
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    52540,48340
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48340 - Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    49854,117281
  • 49854 - Spermadhesin, CUB domain
  • 117281 - Kelch motif
  • 0Direct
    69065,69065
  • 69065 - RNase III domain-like
  • 69065 - RNase III domain-like
  • 0.0000000001212Direct
    47576,143575
  • 47576 - Calponin-homology domain, CH-domain
  • 143575 - GAS2 domain-like
  • 0.0000000002879Direct
    159141,159141
  • 159141 - HIN-2000 domain-like
  • 159141 - HIN-2000 domain-like
  • 0.0000000009349Direct
    101690,69065
  • 101690 - PAZ domain
  • 69065 - RNase III domain-like
  • 0.00000001032Direct
    54236,48366
  • 54236 - Ubiquitin-like
  • 48366 - Ras GEF
  • 0.00000005027Direct
    54236,54001
  • 54236 - Ubiquitin-like
  • 54001 - Cysteine proteinases
  • 0.00000005204Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000005592Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.00000008565Direct
    81296,101898
  • 81296 - E set domains
  • 101898 - NHL repeat
  • 0.0000001363Direct
    57953,49599
  • 57953 - Trimerization domain of TRAF
  • 49599 - TRAF domain-like
  • 0.0000002272Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0000004152Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0000004152Direct
    48726,57424
  • 48726 - Immunoglobulin
  • 57424 - LDL receptor-like module
  • 0.0000004394Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.0000005557Direct
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0.00000115Direct
    49599,57953
  • 49599 - TRAF domain-like
  • 57953 - Trimerization domain of TRAF
  • 0.000003949Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.000004684Direct
    82754,82754
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.000005421Direct
    56112,55681
  • 56112 - Protein kinase-like (PK-like)
  • 55681 - Class II aaRS and biotin synthetases
  • 0.000005712Direct
    57424,48726
  • 57424 - LDL receptor-like module
  • 48726 - Immunoglobulin
  • 0.000006098Direct
    48350,55550
  • 48350 - GTPase activation domain, GAP
  • 55550 - SH2 domain
  • 0.00000795Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.000009433Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0000168Direct
    47986,56112
  • 47986 - DEATH domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00002001Direct
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.000022Direct
    57501,57593
  • 57501 - Cystine-knot cytokines
  • 57593 - Heparin-binding domain from vascular endothelial growth factor
  • 0.000022Direct
    50044,48350
  • 50044 - SH3-domain
  • 48350 - GTPase activation domain, GAP
  • 0.00002612Direct
    55550,52799
  • 55550 - SH2 domain
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.00003641Direct
    54277,57889
  • 54277 - CAD & PB1 domains
  • 57889 - Cysteine-rich domain
  • 0.00003641Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.00004224Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.00004271Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00004455Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0.00005483Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.00007998Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00009932Direct
    100895,48726
  • 100895 - Kazal-type serine protease inhibitors
  • 48726 - Immunoglobulin
  • 0.0001023Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0001065Direct
    47336,53474
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 0.0001065Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.0001065Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0.0001513Direct
    117281,117281
  • 117281 - Kelch motif
  • 117281 - Kelch motif
  • 0.0001815Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0002411Direct
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.0002442Direct
    46785,51206
  • 46785 - "Winged helix" DNA-binding domain
  • 51206 - cAMP-binding domain-like
  • 0.0002571Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.000259Direct
    50249,57756
  • 50249 - Nucleic acid-binding proteins
  • 57756 - Retrovirus zinc finger-like domains
  • 0.0003071Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0006134Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0006134Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.0006134Direct
    55753,47050
  • 55753 - Actin depolymerizing proteins
  • 47050 - VHP, Villin headpiece domain
  • 0.0006202Direct
    56112,48403
  • 56112 - Protein kinase-like (PK-like)
  • 48403 - Ankyrin repeat
  • 0.0006746Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.0006852Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0.0009008Direct
    47592,90209
  • 47592 - SWIB/MDM2 domain
  • 90209 - Ran binding protein zinc finger-like
  • 0.0009976Direct
    50729,48366
  • 50729 - PH domain-like
  • 48366 - Ras GEF
  • 0.0009976Direct
    52954,64586
  • 52954 - Class II aaRS ABD-related
  • 64586 - C-terminal domain of ProRS
  • 0.0009976Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.5836Inherited
    49854,49854
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0.06402Inherited
    46689,46689
  • 46689 - Homeodomain-like
  • 46689 - Homeodomain-like
  • 0.6808Inherited
    103657,50044
  • 103657 - BAR/IMD domain-like
  • 50044 - SH3-domain
  • 0.04282Inherited
    50729,57863
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 0.009609Inherited
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0.0704Inherited
    103657,50729
  • 103657 - BAR/IMD domain-like
  • 50729 - PH domain-like
  • 0.008728Inherited
    69012,55874
  • 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 0.006841Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.001036Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.6432Inherited
    54236,50729
  • 54236 - Ubiquitin-like
  • 50729 - PH domain-like
  • 0.05136Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.001487Inherited
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.002439Inherited
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0.4543Inherited
    48403,82199
  • 48403 - Ankyrin repeat
  • 82199 - SET domain
  • 0.3886Inherited
    56112,47473
  • 56112 - Protein kinase-like (PK-like)
  • 47473 - EF-hand
  • 0.05873Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 1Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.08003Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2915Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.2998Inherited
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.001131Inherited
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.0657Inherited
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.1033Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.8886Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.9858Inherited
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.01004Inherited
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0.4054Inherited
    56491,89811
  • 56491 - A heparin-binding domain
  • 89811 - Amyloid beta a4 protein copper binding domain (domain 2)
  • 0.05136Inherited
    54416,54416
  • 54416 - Amine oxidase N-terminal region
  • 54416 - Amine oxidase N-terminal region
  • 0.007759Inherited
    54416,49998
  • 54416 - Amine oxidase N-terminal region
  • 49998 - Amine oxidase catalytic domain
  • 0.007759Inherited
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0.3886Inherited
    57196,48113
  • 57196 - EGF/Laminin
  • 48113 - Heme-dependent peroxidases
  • 0.02057Inherited
    48403,47986
  • 48403 - Ankyrin repeat
  • 47986 - DEATH domain
  • 0.07496Inherited
    100939,101420
  • 100939 - SPOC domain-like
  • 101420 - C-terminal domain of Ku80
  • 0.2463Inherited
    53300,100939
  • 53300 - vWA-like
  • 100939 - SPOC domain-like
  • 0.2463Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 0.3256Inherited
    56112,103243
  • 56112 - Protein kinase-like (PK-like)
  • 103243 - KA1-like
  • 0.971Inherited
    55394,55394
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 55394 - Bactericidal permeability-increasing protein, BPI
  • 0.002522Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.01254Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.6045Inherited
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.01008Inherited
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.8106Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 1Inherited
    56112,48452
  • 56112 - Protein kinase-like (PK-like)
  • 48452 - TPR-like
  • 0.001413Inherited
    52058,56112
  • 52058 - L domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.02057Inherited
    54171,54171
  • 54171 - DNA-binding domain
  • 54171 - DNA-binding domain
  • 0.2105Inherited
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0.4011Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.3173Inherited
    50044,51695
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 0.5312Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.8436Inherited
    55753,82754
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.003836Inherited
    82754,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 0.007837Inherited
    55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.1184Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1623Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.1994Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.2138Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.839Inherited
    103647,49899
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2105Inherited
    103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.2105Inherited
    82895,57196
  • 82895 - TSP-1 type 1 repeat
  • 57196 - EGF/Laminin
  • 0.2105Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.3886Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.001203Inherited
    49562,53300
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 53300 - vWA-like
  • 0.5389Inherited
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0.01402Inherited
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0.001238Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.01833Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.6607Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.02057Inherited
    55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0.04108Inherited
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.3735Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 1Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.7186Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.1182Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.9571Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 1Inherited
    54980,54211
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.5244Inherited
    54211,54980
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0.5244Inherited
    50447,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0.6432Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 1Inherited
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0.001233Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.004904Inherited
    49599,49599
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0.004911Inherited
    48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0.04282Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.8419Inherited
    51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.01872Inherited
    51735,51735
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.02712Inherited
    52151,55048
  • 52151 - FabD/lysophospholipase-like
  • 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase
  • 0.4124Inherited
    50156,103657
  • 50156 - PDZ domain-like
  • 103657 - BAR/IMD domain-like
  • 0.7985Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 1Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.1001Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.004021Inherited
    57630,57184
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 0.004846Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.07496Inherited
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.07021Inherited
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0.1564Inherited
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 1Inherited
    47794,52540
  • 47794 - Rad51 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1808Inherited
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.001233Inherited
    100909,49899
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.001935Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.05965Inherited
    49265,56496
  • 49265 - Fibronectin type III
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.0111Inherited
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0.01402Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.9571Inherited
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.009609Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.01428Inherited
    48452,57850
  • 48452 - TPR-like
  • 57850 - RING/U-box
  • 0.07496Inherited
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.8574Inherited
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0.9233Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 1Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.01052Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 1Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.01214Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.07929Inherited
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.1047Inherited
    46565,57938
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 0.6825Inherited
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.6825Inherited
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.8324Inherited
    51045,50156
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0.006433Inherited
    50156,52540
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01101Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.01351Inherited
    52540,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.02241Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 1Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.4054Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.4054Inherited
    102860,54197
  • 102860 - mRNA decapping enzyme DcpS N-terminal domain
  • 54197 - HIT-like
  • 0.0191Inherited
    52218,63380
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0.4054Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.6045Inherited
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.1564Inherited
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.02834Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.03165Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.005303Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.09274Inherited
    46565,158702
  • 46565 - Chaperone J-domain
  • 158702 - Sec63 N-terminal domain-like
  • 0.002565Inherited
    48452,46565
  • 48452 - TPR-like
  • 46565 - Chaperone J-domain
  • 0.06071Inherited
    49899,63887
  • 49899 - Concanavalin A-like lectins/glucanases
  • 63887 - P-domain of calnexin/calreticulin
  • 0.139Inherited
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0.2854Inherited
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0.973Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.01214Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.7964Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.9424Inherited
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 1Inherited
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 1Inherited
    57184,49854
  • 57184 - Growth factor receptor domain
  • 49854 - Spermadhesin, CUB domain
  • 0.001413Inherited
    47384,55874
  • 47384 - Homodimeric domain of signal transducing histidine kinase
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 0.002039Inherited
    52172,52172
  • 52172 - CheY-like
  • 52172 - CheY-like
  • 0.009609Inherited
    52172,46689
  • 52172 - CheY-like
  • 46689 - Homeodomain-like
  • 0.01194Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01902Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.7775Inherited
    51445,51445
  • 51445 - (Trans)glycosidases
  • 51445 - (Trans)glycosidases
  • 0.1229Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.7583Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.8419Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57630,57196,57184
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55781,55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    69065,69065,54768
  • 69065 - RNase III domain-like
  • 69065 - RNase III domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.0000000004373Direct
    51735,47336,53474
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 0.0000000009349Direct
    47031,50729,55550
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.00000001248Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0000004152Direct
    48726,57424,57424
  • 48726 - Immunoglobulin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.0000004394Direct
    49599,57953,49599
  • 49599 - TRAF domain-like
  • 57953 - Trimerization domain of TRAF
  • 49599 - TRAF domain-like
  • 0.000003949Direct
    57424,57424,48726
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 48726 - Immunoglobulin
  • 0.000004869Direct
    55753,82754,82754
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.000005421Direct
    82754,82754,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 0.000005421Direct
    50044,48350,55550
  • 50044 - SH3-domain
  • 48350 - GTPase activation domain, GAP
  • 55550 - SH2 domain
  • 0.00000795Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.000009433Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0.000009538Direct
    54001,49758,47473
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0.00001408Direct
    69065,54768,54768
  • 69065 - RNase III domain-like
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.00002384Direct
    57184,57196,49899
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00002384Direct
    57630,57184,57196
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00002384Direct
    55550,55550,52799
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.00003641Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.00007575Direct
    51338,51556,51338
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0.00007655Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00008997Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.000275Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0002919Direct
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0.0003543Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0005152Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0005876Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0005942Direct
    55753,55753,47050
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 47050 - VHP, Villin headpiece domain
  • 0.0006202Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.0007127Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0009913Direct
    48065,50729,48366
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 48366 - Ras GEF
  • 0.0009976Direct
    50044,50044,55550
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0009976Direct
    55681,52954,64586
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 64586 - C-terminal domain of ProRS
  • 0.0009976Direct
    103657,50729,57863
  • 103657 - BAR/IMD domain-like
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 0.001575Inherited
    50729,57863,48403
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0.0191Inherited
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.01402Inherited
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.07496Inherited
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.06071Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1403Inherited
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1033Inherited
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.1033Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.8886Inherited
    54416,54416,49998
  • 54416 - Amine oxidase N-terminal region
  • 54416 - Amine oxidase N-terminal region
  • 49998 - Amine oxidase catalytic domain
  • 0.007759Inherited
    53300,100939,101420
  • 53300 - vWA-like
  • 100939 - SPOC domain-like
  • 101420 - C-terminal domain of Ku80
  • 0.2463Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 1Inherited
    81383,52047,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0.2105Inherited
    55550,50044,51695
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 0.3886Inherited
    55550,55550,50044
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.3886Inherited
    50044,51695,49562
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.5312Inherited
    82754,55753,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.002169Inherited
    55753,55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.1288Inherited
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.8286Inherited
    103647,103647,49899
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2105Inherited
    57603,82895,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.2105Inherited
    103647,103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.2105Inherited
    82895,82895,57196
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 57196 - EGF/Laminin
  • 0.2105Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.001742Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.008284Inherited
    49562,49562,53300
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 53300 - vWA-like
  • 0.3753Inherited
    54768,54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.002039Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.6607Inherited
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.4428Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.8255Inherited
    54980,54211,54980
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0.5244Inherited
    52540,50447,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0.5244Inherited
    50447,54980,54211
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.5244Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 1Inherited
    51735,51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.003603Inherited
    50129,51735,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.01174Inherited
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 1Inherited
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.002439Inherited
    57630,57184,49899
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.03783Inherited
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.1217Inherited
    57196,57184,49899
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00862Inherited
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.001233Inherited
    82109,100909,49899
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.001935Inherited
    49265,49265,56496
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.003499Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.007759Inherited
    47986,47986,52540
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.004846Inherited
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.009609Inherited
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.77Inherited
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.8574Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2253Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.005838Inherited
    47031,50729,56112
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.03783Inherited
    46565,57938,49493
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.5389Inherited
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.6825Inherited
    50156,52540,51045
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.002565Inherited
    51045,51045,50156
  • 51045 - WW domain
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0.005248Inherited
    52540,51045,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.01726Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.4054Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.01107Inherited
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.01726Inherited
    90193,90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.01726Inherited
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.02241Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.03147Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1648Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6626Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.5787Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.6909Inherited
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.01214Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.6945Inherited
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 1Inherited
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 1Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.03499Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.007759Inherited
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.07671Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.9145Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
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