SUPERFAMILY 1.75 HMM library and genome assignments server

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Biological Process (BP): cellular response to endogenous stimulus

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Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + 3:   biological_process [GO:0008150] <24>
+ + 2:   response to stimulus [GO:0050896] <16>(133|153) (688|755|432)
+ 1:   response to endogenous stimulus [GO:0009719] <11>(29|29) (222|162|80)
0:   cellular response to endogenous stimulus [GO:0071495] <10>(22|20) (174|129|65)
- 1:   cellular response to organonitrogen compound [GO:0071417] <61>(8|7) (95|64|25)
- 1:   cellular response to hormone stimulus [GO:0032870] <15>(15|15) (102|60|27)
- 1:   response to cell cycle checkpoint signaling [GO:0072396] <5>(0|0) (2|0|0)
- 1:   cellular response to fibroblast growth factor stimulus [GO:0044344] <2>(1|1) (14|11|5)
- 1:   cellular response to nerve growth factor stimulus [GO:1990090] <2>(2|1) (13|11|6)
- 1:   cellular response to BMP stimulus [GO:0071773] <1>(0|0) (14|7|0)
- 1:   cellular response to transforming growth factor beta stimulus [GO:0071560] <1>(0|0) (16|9|8)
- 1:   cellular response to epidermal growth factor stimulus [GO:0071364](0|0) (18|20|14)
- 1:   cellular response to glial cell derived neurotrophic factor [GO:1990792](0|0) (0|0|0)
- 1:   cellular response to platelet-derived growth factor stimulus [GO:0036120](1|1) (4|4|2)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Cytokine0.00056330.000006257Direct
Histidine-containing phosphotransfer domain, HPT domain0.00000015460.0009289Direct
Metallothionein0.00000024520.00005318Direct
Roadblock/LC7 domain00Direct
Stathmin0.00000014470.00003009Direct
Transducin (heterotrimeric G protein), gamma chain0.00000093120.0005774Direct
EF-hand0.22250.03626Inherited
Cysteine proteinases0.71290.5666Inherited
Acyl-CoA N-acyltransferases (Nat)0.000083670.03235Inherited
Aquaporin-like0.33570.855Inherited
NAD(P)-linked oxidoreductase0.00007620.05664Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.16491Inherited
Annexin0.066110.2496Inherited
Carbonic anhydrase0.034640.1012Inherited
alpha/beta-Hydrolases11Inherited
Family A G protein-coupled receptor-like0.08360.00001085Inherited
Bet v1-like0.067750.4305Inherited
14-3-3 protein0.000022920.001258Inherited
4-helical cytokines11Inherited
(Trans)glycosidases0.000000041910.2207Inherited
Mitochondrial carrier0.0000030290.02971Inherited
Insulin-like11Inherited


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Family

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Bee venom hyaluronidase00Direct
Fibroblast growth factors (FGF)0.000090820.00000135Direct
Metallothionein0.00000069630.0001437Direct
N-acetyl transferase, NAT0.000059730.0004417Direct
Phosphorelay protein-like0.000000010980.000001124Direct
Roadblock/LC7 domain00Direct
Stathmin0.00000026010.00005533Direct
Transducin (heterotrimeric G protein), gamma chain0.0000018840.0007479Direct
Papain-like0.63130.9462Inherited
Aquaporin-like0.29570.846Inherited
Aldo-keto reductases (NADP)0.000250.1177Inherited
UDPGT-like0.010250.09546Inherited
Annexin0.055070.2627Inherited
Carbonic anhydrase0.029070.1025Inherited
Carboxylesterase0.0490.1461Inherited
14-3-3 protein0.000045580.002618Inherited
Long-chain cytokines11Inherited
Mitochondrial carrier0.000010040.05534Inherited
G proteins0.000085161Inherited
Insulin-like0.97131Inherited


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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Roadblock/LC7 domain0Direct
Cystine-knot cytokines0Direct
Snake toxin-like0Direct
SMAD/FHA domain0Direct
SMAD MH1 domain0Direct
Protein kinase-like (PK-like)9.676e-16Direct
IP3 receptor type 1 binding core, domain 20.000000000000001898Direct
Amine oxidase N-terminal region0.00000000000007488Direct
Amine oxidase catalytic domain0.00000000000009888Direct
Spermadhesin, CUB domain0.0000000000006296Direct
MIR domain0.0000000001756Direct
GAS2 domain-like0.0000001822Direct
Calpain large subunit, middle domain (domain III)0.0000001822Direct
alpha-ketoacid dehydrogenase kinase, N-terminal domain0.0000004311Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000005722Direct
SH2 domain0.0000008258Direct
TB module/8-cys domain0.0000009204Direct
Nicotinic receptor ligand binding domain-like0.0000009483Direct
Cytokine0.00000411Direct
Family A G protein-coupled receptor-like0.000007182Direct
Glucocorticoid receptor-like (DNA-binding domain)0.000007634Direct
DNA-binding domain of EIN3-like0.000007709Direct
Immunoglobulin0.000009007Direct
Stathmin0.0000202Direct
p53-like transcription factors0.0000261Direct
Moesin tail domain0.00003496Direct
Metallothionein0.00003594Direct
HD-domain/PDEase-like0.00003699Direct
Transcription factor STAT-4 N-domain0.00003729Direct
STAT0.00003729Direct
L domain-like0.0000375Direct
Periplasmic binding protein-like I0.00005222Direct
Nuclear receptor coactivator interlocking domain0.0000605Direct
RNI-like0.00006314Direct
N-terminal coiled coil domain from apc0.0001843Direct
Tumor suppressor gene product Apc0.0001843Direct
Ras GEF0.000294Direct
ABC transporter transmembrane region0.0003536Direct
Transducin (heterotrimeric G protein), gamma chain0.0004068Direct
Rad51 N-terminal domain-like0.0004499Direct
Histidine-containing phosphotransfer domain, HPT domain0.0006602Direct
14-3-3 protein0.0009Direct
Plexin repeat1Inherited
Integrin domains1Inherited
vWA-like1Inherited
BAR/IMD domain-like0.006369Inherited
Bromodomain0.2034Inherited
ArfGap/RecO-like zinc finger0.2436Inherited
ARM repeat1Inherited
Insulin-like1Inherited
Tetraspanin1Inherited
Ubiquitin-like0.01344Inherited
Calponin-homology domain, CH-domain0.2375Inherited
Zn2/Cys6 DNA-binding domain0.3581Inherited
beta-beta-alpha zinc fingers0.1102Inherited
UBC-like0.01359Inherited
Ribosomal protein S5 domain 2-like0.821Inherited
Class II aaRS and biotin synthetases1Inherited
Caspase-like0.08017Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Smc hinge domain0.01367Inherited
Arginase/deacetylase0.008131Inherited
DHS-like NAD/FAD-binding domain0.09426Inherited
DUSP-like0.001125Inherited
EPT/RTPC-like0.008055Inherited
BPTI-like0.004586Inherited
FnI-like domain0.05926Inherited
SAND domain-like0.2129Inherited
HMG-box0.5041Inherited
Rap/Ran-GAP0.001205Inherited
Voltage-gated potassium channels0.6672Inherited
GAF domain-like0.007309Inherited
Aquaporin-like0.7571Inherited
Acyl-CoA N-acyltransferases (Nat)0.02479Inherited
SpoIIaa-like0.1173Inherited
Hormone receptor domain0.101Inherited
CalX-like0.006096Inherited
Amyloid beta a4 protein copper binding domain (domain 2)0.008782Inherited
A heparin-binding domain0.0127Inherited
CAPPD, an extracellular domain of amyloid beta A4 protein0.01756Inherited
Concanavalin A-like lectins/glucanases0.7769Inherited
EF-hand0.02784Inherited
Nudix0.9202Inherited
Nuclear receptor ligand-binding domain0.001236Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.9925Inherited
Prefoldin0.2966Inherited
Metal cation-transporting ATPase, ATP-binding domain N1Inherited
Fibrinogen C-terminal domain-like0.6576Inherited
Kelch motif0.005379Inherited
NAD(P)-linked oxidoreductase0.04408Inherited
A DNA-binding domain in eukaryotic transcription factors0.1173Inherited
POZ domain1Inherited
Fibronectin type III0.005447Inherited
Second domain of FERM0.005211Inherited
SOCS box-like0.8328Inherited
4-helical cytokines1Inherited
cAMP-binding domain-like0.07907Inherited
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit0.02336Inherited
Nucleotide cyclase0.07224Inherited
(Phosphotyrosine protein) phosphatases II0.01373Inherited
SH3-domain0.03854Inherited
Carbonic anhydrase0.08017Inherited
DNase I-like0.335Inherited
Integrin alpha N-terminal domain0.286Inherited
TNF-like0.01359Inherited
PH domain-like0.585Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.008747Inherited
Phospholipase A2, PLA20.2502Inherited
GTPase activation domain, GAP0.02895Inherited
Metalloproteases ("zincins"), catalytic domain0.9584Inherited
Cyclin-like0.6939Inherited
Galactose-binding domain-like1Inherited
SAM/Pointed domain0.327Inherited
Cytochrome P4501Inherited
alpha/beta-Hydrolases1Inherited
TPR-like1Inherited
NAC domain1Inherited
C-terminal, gelsolin-like domain of Sec23/240.04275Inherited
Actin depolymerizing proteins0.07066Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.3897Inherited
PLC-like phosphodiesterases0.5491Inherited
Growth factor receptor domain1Inherited
Translation proteins1Inherited
VHP, Villin headpiece domain0.03746Inherited
PDZ domain-like0.9993Inherited
E set domains0.9368Inherited
"Winged helix" DNA-binding domain0.5045Inherited
ACT-like1Inherited
Cysteine proteinases0.4855Inherited
Periplasmic binding protein-like II0.007588Inherited
AhpD-like0.01073Inherited
ClpS-like0.1713Inherited
RNA-binding domain, RBD0.03174Inherited
Cysteine-rich domain0.02069Inherited
DBL homology domain (DH-domain)0.9143Inherited
DEATH domain0.01Inherited
Leucine zipper domain0.8713Inherited
PP2C-like0.9648Inherited
Chlorophyll a-b binding protein0.7725Inherited
RmlC-like cupins1Inherited
EGF/Laminin0.3112Inherited
(Trans)glycosidases0.18Inherited
NHL repeat0.003344Inherited
B-box zinc-binding domain0.3103Inherited
LDL receptor-like module0.3507Inherited
Pectin lyase-like0.8801Inherited
Interleukin 8-like chemokines0.9143Inherited
Hect, E3 ligase catalytic domain0.01749Inherited
Glycerol-3-phosphate (1)-acyltransferase0.4162Inherited
HSP40/DnaJ peptide-binding domain0.2319Inherited
Cystatin/monellin0.08017Inherited
lambda repressor-like DNA-binding domains0.7148Inherited
DnaJ/Hsp40 cysteine-rich domain0.1075Inherited
WW domain0.03946Inherited
SRF-like0.3602Inherited
Ankyrin repeat0.972Inherited
SET domain0.8518Inherited
FYVE/PHD zinc finger0.9796Inherited
Mitochondrial carrier0.02272Inherited
Annexin0.2048Inherited
Homodimeric domain of signal transducing histidine kinase0.01749Inherited
CCCH zinc finger0.001585Inherited
CheY-like0.3708Inherited
F-box domain0.06763Inherited
Bet v1-like0.3631Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.04725Inherited
CAD & PB1 domains1Inherited
Chaperone J-domain1Inherited
DNA-binding domain0.3212Inherited
SAP domain0.05485Inherited
WRKY DNA-binding domain1Inherited
Histone-fold0.5911Inherited
Homeodomain-like1Inherited
Integrin beta tail domain1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54001,55205
  • 54001 - Cysteine proteinases
  • 55205 - EPT/RTPC-like
  • 0Direct
    54495,54211
  • 54495 - UBC-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0Direct
    143791,54236
  • 143791 - DUSP-like
  • 54236 - Ubiquitin-like
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    49854,117281
  • 49854 - Spermadhesin, CUB domain
  • 117281 - Kelch motif
  • 0Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 9.676e-16Direct
    100909,49899
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00000000000000466Direct
    54416,49998
  • 54416 - Amine oxidase N-terminal region
  • 49998 - Amine oxidase catalytic domain
  • 0.00000000000001797Direct
    54416,54416
  • 54416 - Amine oxidase N-terminal region
  • 54416 - Amine oxidase N-terminal region
  • 0.00000000000002322Direct
    47576,143575
  • 47576 - Calponin-homology domain, CH-domain
  • 143575 - GAS2 domain-like
  • 0.0000000000004769Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.000000000002769Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.000000000002858Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.00000000001315Direct
    54236,48366
  • 54236 - Ubiquitin-like
  • 48366 - Ras GEF
  • 0.0000000002653Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.0000000005982Direct
    48726,57424
  • 48726 - Immunoglobulin
  • 57424 - LDL receptor-like module
  • 0.000000002575Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.00000001973Direct
    81296,101898
  • 81296 - E set domains
  • 101898 - NHL repeat
  • 0.00000003159Direct
    48350,55550
  • 48350 - GTPase activation domain, GAP
  • 55550 - SH2 domain
  • 0.00000003687Direct
    57424,48726
  • 57424 - LDL receptor-like module
  • 48726 - Immunoglobulin
  • 0.0000000421Direct
    50044,48350
  • 50044 - SH3-domain
  • 48350 - GTPase activation domain, GAP
  • 0.0000001346Direct
    69012,55874
  • 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 0.0000001362Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0000001887Direct
    82754,82754
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.0000002279Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0.000000305Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0000004411Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.000001396Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.000001396Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.000001462Direct
    55550,52799
  • 55550 - SH2 domain
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.00000163Direct
    54277,57889
  • 54277 - CAD & PB1 domains
  • 57889 - Cysteine-rich domain
  • 0.00000163Direct
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0.000001983Direct
    52172,52172
  • 52172 - CheY-like
  • 52172 - CheY-like
  • 0.000002414Direct
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.000003552Direct
    100895,48726
  • 100895 - Kazal-type serine protease inhibitors
  • 48726 - Immunoglobulin
  • 0.0000076Direct
    46785,51206
  • 46785 - "Winged helix" DNA-binding domain
  • 51206 - cAMP-binding domain-like
  • 0.0000316Direct
    55753,47050
  • 55753 - Actin depolymerizing proteins
  • 47050 - VHP, Villin headpiece domain
  • 0.00003228Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00003729Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00003729Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.00003729Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.00004118Direct
    48403,82199
  • 48403 - Ankyrin repeat
  • 82199 - SET domain
  • 0.00006404Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00006642Direct
    117281,117281
  • 117281 - Kelch motif
  • 117281 - Kelch motif
  • 0.00009675Direct
    47592,90209
  • 47592 - SWIB/MDM2 domain
  • 90209 - Ran binding protein zinc finger-like
  • 0.0001283Direct
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.0001482Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0001745Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0001745Direct
    56112,48452
  • 56112 - Protein kinase-like (PK-like)
  • 48452 - TPR-like
  • 0.0001843Direct
    57184,49854
  • 57184 - Growth factor receptor domain
  • 49854 - Spermadhesin, CUB domain
  • 0.0001843Direct
    47794,52540
  • 47794 - Rad51 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0001883Direct
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.0002202Direct
    55753,82754
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.0002333Direct
    103657,50729
  • 103657 - BAR/IMD domain-like
  • 50729 - PH domain-like
  • 0.0002907Direct
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0003088Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003536Direct
    82754,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 0.0005173Direct
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.000558Direct
    56112,55681
  • 56112 - Protein kinase-like (PK-like)
  • 55681 - Class II aaRS and biotin synthetases
  • 0.0009121Direct
    51045,50156
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0.0009121Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0009266Direct
    103657,50044
  • 103657 - BAR/IMD domain-like
  • 50044 - SH3-domain
  • 0.007155Inherited
    50729,57863
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 0.08017Inherited
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.1173Inherited
    57863,48403
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0.1173Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.08017Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.3602Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.07278Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.006318Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.6244Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.07427Inherited
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.01164Inherited
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.101Inherited
    56491,89811
  • 56491 - A heparin-binding domain
  • 89811 - Amyloid beta a4 protein copper binding domain (domain 2)
  • 0.008782Inherited
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0.009329Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.9184Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 1Inherited
    49265,56496
  • 49265 - Fibronectin type III
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.00794Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.1173Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.005211Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.1821Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.8328Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.06472Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.009895Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 1Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.001861Inherited
    54236,50729
  • 54236 - Ubiquitin-like
  • 50729 - PH domain-like
  • 0.008782Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.1173Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.1173Inherited
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.01439Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1077Inherited
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.02844Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.09937Inherited
    55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.1173Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.3845Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.4475Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.5491Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.6244Inherited
    50044,51695
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 0.6576Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.8209Inherited
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.9443Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.03596Inherited
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0.009674Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.135Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.8842Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.09299Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.0333Inherited
    51445,51445
  • 51445 - (Trans)glycosidases
  • 51445 - (Trans)glycosidases
  • 0.4221Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.4783Inherited
    52058,56112
  • 52058 - L domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.09937Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.02103Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.01894Inherited
    46565,57938
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 0.02844Inherited
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.04034Inherited
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.1897Inherited
    50156,52540
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00162Inherited
    52540,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.003498Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.587Inherited
    47384,55874
  • 47384 - Homodimeric domain of signal transducing histidine kinase
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 0.01749Inherited
    52172,46689
  • 52172 - CheY-like
  • 46689 - Homeodomain-like
  • 0.1746Inherited
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0.001861Inherited
    56112,47473
  • 56112 - Protein kinase-like (PK-like)
  • 47473 - EF-hand
  • 0.1821Inherited
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0.1173Inherited
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0.514Inherited
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0.7388Inherited
    54171,54171
  • 54171 - DNA-binding domain
  • 54171 - DNA-binding domain
  • 0.2502Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 1Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55781,55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0Direct
    82109,100909,49899
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00000000000000466Direct
    54416,54416,49998
  • 54416 - Amine oxidase N-terminal region
  • 54416 - Amine oxidase N-terminal region
  • 49998 - Amine oxidase catalytic domain
  • 0.0000000000000127Direct
    47986,47986,52540
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0000000000002189Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.0000000000004619Direct
    47031,50729,55550
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0000000002773Direct
    48726,57424,57424
  • 48726 - Immunoglobulin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.000000002575Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000003159Direct
    57424,57424,48726
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 48726 - Immunoglobulin
  • 0.00000003311Direct
    50044,48350,55550
  • 50044 - SH3-domain
  • 48350 - GTPase activation domain, GAP
  • 55550 - SH2 domain
  • 0.00000003687Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0.00000004494Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000006705Direct
    55753,82754,82754
  • 55753 - Actin depolymerizing proteins
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.0000002279Direct
    82754,82754,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 0.0000002279Direct
    54001,49758,47473
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0.0000002439Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0000009639Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000001163Direct
    55550,55550,52799
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.00000163Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.000004715Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.000005889Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.000007974Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.00002486Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.00003159Direct
    55753,55753,47050
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 47050 - VHP, Villin headpiece domain
  • 0.00003228Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00003729Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00003729Direct
    103657,50729,57863
  • 103657 - BAR/IMD domain-like
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 0.0000881Direct
    82754,55753,55753
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.0001248Direct
    50044,50044,55550
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0001283Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0001283Direct
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0001337Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0001745Direct
    57903,57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.0003437Direct
    50156,52540,51045
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.0003437Direct
    51045,51045,50156
  • 51045 - WW domain
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0.0007337Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1173Inherited
    50729,57863,48403
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 48403 - Ankyrin repeat
  • 0.1173Inherited
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.08017Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.07278Inherited
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.01063Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.02844Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 1Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 1Inherited
    49265,49265,56496
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.003047Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.09503Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01998Inherited
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.001432Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.1173Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.008131Inherited
    55753,55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.1173Inherited
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.3741Inherited
    55550,50044,51695
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 0.4221Inherited
    55550,55550,50044
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.4221Inherited
    50044,51695,49562
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.6576Inherited
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.9443Inherited
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.9443Inherited
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.1713Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.2048Inherited
    46565,57938,49493
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.02502Inherited
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.03819Inherited
    52540,51045,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.002632Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2614Inherited
    81383,52047,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0.5431Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 1Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
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