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Biological Process (BP): cellular response to external stimulus

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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + 3:   biological_process [GO:0008150] <24>
+ + 2:   response to stimulus [GO:0050896] <16>(133|153) (688|755|432)
+ 1:   response to external stimulus [GO:0009605] <14>(48|44) (348|293|160)
0:   cellular response to external stimulus [GO:0071496] <3>(7|5) (106|60|29)
- 1:   cellular response to extracellular stimulus [GO:0031668] <9>(6|4) (89|48|23)
- 1:   cellular response to external biotic stimulus [GO:0071217](0|0) (2|2|2)
- 1:   cellular response to mechanical stimulus [GO:0071260](1|1) (15|10|4)


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
all-alpha NTP pyrophosphatases0.00023090.00009229Direct
Aquaporin-like0.00000069020.00000208Direct
DNA/RNA polymerases0.0000071410.000007529Direct
Heme-dependent catalase-like0.00023090.00001795Direct
WD40 repeat-like0.000031020.00000000000008102Direct
P-loop containing nucleoside triphosphate hydrolases0.0038850.0001153Inherited
Radical SAM enzymes0.029920.1616Inherited


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Aquaporin-like0.00000014620.000002068Direct
GABARAP-like0.00029420.0008344Direct
Heme-dependent catalases0.00010830.00001006Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0.00000000075080.00000000000003627Direct
WD40-repeat0.0000035350.00000000009368Direct


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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
FLJ32549 domain-like0Direct
FLJ32549 C-terminal domain-like0Direct
Amine oxidase catalytic domain9.676e-16Direct
Amine oxidase N-terminal region9.676e-16Direct
LexA/Signal peptidase0.000000000000001898Direct
WD40 repeat-like0.00000000000004297Direct
Zn2/Cys6 DNA-binding domain0.0000000000008724Direct
UBC-like0.000000000001346Direct
Satiety factor CART (cocaine and amphetamine regulated transcript)0.00000000000638Direct
RecA protein, C-terminal domain0.00000000001692Direct
RuvA domain 2-like0.00000000003938Direct
DNA helicase RuvA subunit, C-terminal domain0.0000000000408Direct
Serum albumin-like0.00000000009232Direct
PHP domain-like0.0000000001699Direct
alpha-ketoacid dehydrogenase kinase, N-terminal domain0.000000001285Direct
AhpD-like0.000000001366Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0.000000001917Direct
CBS-domain pair0.000000008594Direct
ARM repeat0.00000002299Direct
GLA-domain0.0000004186Direct
Aquaporin-like0.000001343Direct
HLH, helix-loop-helix DNA-binding domain0.000001486Direct
KA1-like0.00000316Direct
YgaC/TfoX-N like0.00000384Direct
DNA/RNA polymerases0.000004959Direct
Ribosomal protein S5 domain 2-like0.00000584Direct
Heme-dependent catalase-like0.00001196Direct
Type II DNA topoisomerase0.00001772Direct
GIY-YIG endonuclease0.00003169Direct
Nop domain0.00004554Direct
eIF-2-alpha, C-terminal domain0.00005032Direct
eIF2alpha middle domain-like0.00005032Direct
all-alpha NTP pyrophosphatases0.00006301Direct
P-loop containing nucleoside triphosphate hydrolases0.00007905Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.00008542Direct
FF domain0.00009649Direct
Bcl-2 inhibitors of programmed cell death0.0001086Direct
"Winged helix" DNA-binding domain0.0001233Direct
HD-domain/PDEase-like0.0001843Direct
TGS-like0.0002156Direct
C-terminal UvrC-binding domain of UvrB0.0003291Direct
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)0.0003331Direct
Inhibitor of apoptosis (IAP) repeat0.000663Direct
beta-beta-alpha zinc fingers0.8377Inherited
Fibronectin type III1Inherited
Metalloproteases ("zincins"), catalytic domain0.9563Inherited
Class II aaRS and biotin synthetases0.07657Inherited
GAF domain-like0.001088Inherited
Integrin domains0.02764Inherited
Integrin beta tail domain0.03004Inherited
Caspase-like0.1003Inherited
TNF receptor-like0.191Inherited
Periplasmic binding protein-like I0.4459Inherited
Ankyrin repeat0.5291Inherited
vWA-like0.6284Inherited
HMG-box0.8163Inherited
Plexin repeat1Inherited
L domain-like1Inherited
Toll/Interleukin receptor TIR domain1Inherited
DEATH domain1Inherited
ABC transporter transmembrane region0.01318Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.2139Inherited
TRAF domain-like0.1237Inherited
POZ domain0.1617Inherited
Nudix0.1972Inherited
Thioredoxin-like0.9121Inherited
BAR/IMD domain-like0.06272Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.2342Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.3115Inherited
PDZ domain-like0.4261Inherited
Integrin alpha N-terminal domain0.002546Inherited
Nucleic acid-binding proteins0.04285Inherited
RING/U-box0.1808Inherited
Growth factor receptor domain0.3659Inherited
EGF/Laminin1Inherited
Concanavalin A-like lectins/glucanases1Inherited
Frizzled cysteine-rich domain0.2342Inherited
Fibrinogen C-terminal domain-like0.756Inherited
Cysteine proteinases0.03808Inherited
Ran binding protein zinc finger-like0.1495Inherited
Protein kinase-like (PK-like)0.04387Inherited
GAS2 domain-like0.03316Inherited
Quinoprotein alcohol dehydrogenase-like0.001043Inherited
Calponin-homology domain, CH-domain0.1059Inherited
PEP carboxykinase N-terminal domain0.008881Inherited
PEP carboxykinase-like0.002487Inherited
E set domains1Inherited
Phospholipase D/nuclease0.04561Inherited
Homodimeric domain of signal transducing histidine kinase0.2085Inherited
HAD-like0.5603Inherited
Phosphoglycerate mutase-like0.5748Inherited
ACT-like0.01061Inherited
Nucleotidyltransferase0.5417Inherited
Homeodomain-like1Inherited
ACP-like0.04901Inherited
CoA-dependent acyltransferases0.05496Inherited
Acetyl-CoA synthetase-like0.2231Inherited
Cupredoxins0.4332Inherited
MFS general substrate transporter0.6356Inherited
Riboflavin synthase domain-like0.7126Inherited
Radical SAM enzymes0.1301Inherited
YVTN repeat-like/Quinoprotein amine dehydrogenase0.005294Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2617Inherited
CheY-like0.1249Inherited
Aminoacid dehydrogenase-like, N-terminal domain0.2239Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9372Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
46785,51306
  • 46785 - "Winged helix" DNA-binding domain
  • 51306 - LexA/Signal peptidase
  • 0Direct
    54495,54211
  • 54495 - UBC-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    54416,54416
  • 54416 - Amine oxidase N-terminal region
  • 54416 - Amine oxidase N-terminal region
  • 0Direct
    158548,160651
  • 158548 - FLJ32549 domain-like
  • 160651 - FLJ32549 C-terminal domain-like
  • 0Direct
    54416,49998
  • 54416 - Amine oxidase N-terminal region
  • 49998 - Amine oxidase catalytic domain
  • 0Direct
    47576,143575
  • 47576 - Calponin-homology domain, CH-domain
  • 143575 - GAS2 domain-like
  • 0.000000000000009141Direct
    81301,81271
  • 81301 - Nucleotidyltransferase
  • 81271 - TGS-like
  • 0.000000000007376Direct
    50249,47781
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 0.000000000007516Direct
    54631,54631
  • 54631 - CBS-domain pair
  • 54631 - CBS-domain pair
  • 0.00000000001692Direct
    47781,46929
  • 47781 - RuvA domain 2-like
  • 46929 - DNA helicase RuvA subunit, C-terminal domain
  • 0.0000000000408Direct
    56112,103243
  • 56112 - Protein kinase-like (PK-like)
  • 103243 - KA1-like
  • 0.00000000006441Direct
    50156,103657
  • 50156 - PDZ domain-like
  • 103657 - BAR/IMD domain-like
  • 0.00000000009149Direct
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.00000000009232Direct
    52540,54752
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 54752 - RecA protein, C-terminal domain
  • 0.00000000009232Direct
    69012,55874
  • 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 0.0000000003829Direct
    109604,81301
  • 109604 - HD-domain/PDEase-like
  • 81301 - Nucleotidyltransferase
  • 0.0000000005449Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0.000000001917Direct
    56112,55681
  • 56112 - Protein kinase-like (PK-like)
  • 55681 - Class II aaRS and biotin synthetases
  • 0.0000004242Direct
    57630,57184
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 0.000002256Direct
    56112,48371
  • 56112 - Protein kinase-like (PK-like)
  • 48371 - ARM repeat
  • 0.00000317Direct
    49599,54695
  • 49599 - TRAF domain-like
  • 54695 - POZ domain
  • 0.000008662Direct
    50249,116742
  • 50249 - Nucleic acid-binding proteins
  • 116742 - eIF2alpha middle domain-like
  • 0.00005032Direct
    116742,110993
  • 116742 - eIF2alpha middle domain-like
  • 110993 - eIF-2-alpha, C-terminal domain
  • 0.00005032Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.0001613Direct
    56235,52402
  • 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases)
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 0.000217Direct
    52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.0002271Direct
    47336,52777
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 0.0002799Direct
    54211,56719
  • 54211 - Ribosomal protein S5 domain 2-like
  • 56719 - Type II DNA topoisomerase
  • 0.0003291Direct
    47212,56112
  • 47212 - FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
  • 56112 - Protein kinase-like (PK-like)
  • 0.0003331Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.0004944Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.000527Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 1Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.008881Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.008881Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01576Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.105Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.105Inherited
    48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.2139Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2139Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 1Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01318Inherited
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.0226Inherited
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0.2342Inherited
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.3115Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.702Inherited
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.9151Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.001705Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.09164Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.4495Inherited
    49265,56496
  • 49265 - Fibronectin type III
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.2645Inherited
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.02764Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.001088Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.001088Inherited
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0.008881Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 1Inherited
    47384,55874
  • 47384 - Homodimeric domain of signal transducing histidine kinase
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 0.2085Inherited
    56801,47336
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 0.004812Inherited
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0.0226Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.0226Inherited
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.09922Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57630,57196,57184
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    54416,54416,49998
  • 54416 - Amine oxidase N-terminal region
  • 54416 - Amine oxidase N-terminal region
  • 49998 - Amine oxidase catalytic domain
  • 0Direct
    55781,55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.00000000000001446Direct
    109604,81301,81271
  • 109604 - HD-domain/PDEase-like
  • 81301 - Nucleotidyltransferase
  • 81271 - TGS-like
  • 0.000000000007376Direct
    50249,47781,46929
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 46929 - DNA helicase RuvA subunit, C-terminal domain
  • 0.0000000000408Direct
    48552,48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.00000000009232Direct
    57630,57184,57196
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0000001898Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000002256Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.00004076Direct
    50249,116742,110993
  • 50249 - Nucleic acid-binding proteins
  • 116742 - eIF2alpha middle domain-like
  • 110993 - eIF-2-alpha, C-terminal domain
  • 0.00005032Direct
    52777,56801,47336
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 0.0001136Direct
    52777,52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.0001338Direct
    47336,52777,52777
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.0002614Direct
    55874,54211,56719
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 56719 - Type II DNA topoisomerase
  • 0.0003291Direct
    57630,57184,49899
  • 57630 - GLA-domain
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0003291Direct
    56801,47336,52777
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 0.0006966Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.105Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2202Inherited
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0226Inherited
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.0226Inherited
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0.2342Inherited
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.3115Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.946Inherited
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.6613Inherited
    49265,49265,56496
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 56496 - Fibrinogen C-terminal domain-like
  • 0.1396Inherited
    57184,57196,49899
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.001705Inherited
    57196,57184,49899
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.3572Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.001088Inherited
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0.01632Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
    Plot tree as:   Download Newick format tree:   Browsing in Tree_gateway:
    (show help)