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Biological Process (BP): organic substance metabolic process

(show info)

Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + 2:   biological_process [GO:0008150] <24>
+ 1:   metabolic process [GO:0008152] <14>(305|421) (985|1042|489)
0:   organic substance metabolic process [GO:0071704] <43>(284|392) (950|1000|457)
- 1:   organic cyclic compound metabolic process [GO:1901360] <97>(163|194) (614|485|206)
- 1:   organonitrogen compound metabolic process [GO:1901564] <67>(198|251) (718|667|296)
- 1:   cellular ketone metabolic process [GO:0042180] <44>(11|12) (38|13|3)
- 1:   carbohydrate derivative metabolic process [GO:1901135] <39>(67|78) (282|158|58)
- 1:   organic substance catabolic process [GO:1901575] <38>(75|84) (321|223|75)
- 1:   organic substance biosynthetic process [GO:1901576] <35>(155|193) (564|420|184)
- 1:   organophosphate metabolic process [GO:0019637] <35>(71|68) (245|149|60)
- 1:   organic hydroxy compound metabolic process [GO:1901615] <34>(27|29) (130|63|19)
- 1:   ether metabolic process [GO:0018904] <30>(1|1) (14|3|0)
- 1:   polyketide metabolic process [GO:0030638] <19>(3|2) (11|9|3)
- 1:   cellular aldehyde metabolic process [GO:0006081] <17>(17|18) (38|16|7)
- 1:   macromolecule metabolic process [GO:0043170] <16>(163|212) (681|695|307)
- 1:   organic acid metabolic process [GO:0006082] <11>(77|93) (289|221|100)
- 1:   flavonoid metabolic process [GO:0009812] <10>(3|3) (6|2|0)
- 1:   lipid metabolic process [GO:0006629] <8>(50|52) (177|123|56)
- 1:   olefin metabolic process [GO:1900673] <8>(1|1) (5|2|0)
- 1:   acetate ester metabolic process [GO:1900619] <7>(0|0) (2|1|0)
- 1:   cellular alkane metabolic process [GO:0043446] <7>(0|0) (1|0|0)
- 1:   carbon fixation [GO:0015977] <6>(1|1) (3|0|0)
- 1:   fatty acid derivative metabolic process [GO:1901568] <6>(9|6) (31|13|3)
- 1:   carbohydrate metabolic process [GO:0005975] <5>(34|46) (122|77|37)
- 1:   organosilicon metabolic process [GO:0018945] <5>(0|0) (0|0|0)
- 1:   halogenated hydrocarbon metabolic process [GO:0042197] <4>(0|0) (1|0|0)
- 1:   S-adenosylmethionine metabolic process [GO:0046500] <3>(1|1) (7|2|1)
- 1:   cellular alkyne metabolic process [GO:0043452] <3>(0|0) (0|0|0)
- 1:   choline metabolic process [GO:0019695] <3>(1|0) (5|2|0)
- 1:   poly(hydroxyalkanoate) metabolic process [GO:1901440] <3>(0|0) (1|0|0)
- 1:   arugosin metabolic process [GO:1900585] <2>(0|0) (0|0|0)
- 1:   austinol metabolic process [GO:1900558] <2>(0|0) (0|0|0)
- 1:   betaine aldehyde metabolic process [GO:1902061] <2>(0|0) (0|0|0)
- 1:   candicidin metabolic process [GO:1901125] <2>(0|0) (0|0|0)
- 1:   cyanide metabolic process [GO:0019499] <2>(0|0) (2|0|0)
- 1:   dehydroaustinol metabolic process [GO:1900561] <2>(0|0) (0|0|0)
- 1:   organometal metabolic process [GO:0018942] <2>(0|0) (0|0|0)
- 1:   phosphinothricin metabolic process [GO:1901764] <2>(0|0) (0|0|0)
- 1:   thioester metabolic process [GO:0035383] <2>(3|2) (34|24|8)
- 1:   aldoxime metabolic process [GO:0019330] <1>(0|0) (0|0|0)
- 1:   coenzyme M metabolic process [GO:0019296] <1>(1|0) (1|0|0)
- 1:   poly(3-hydroxyalkanoate) metabolic process [GO:0042620] <1>(0|0) (0|0|0)
- 1:   dimethyl sulfoxide metabolic process [GO:0018907](0|0) (0|0|0)
- 1:   naphthalenesulfonate metabolic process [GO:0018984](0|0) (0|0|0)
- 1:   nitroglycerin metabolic process [GO:0018937](0|0) (0|0|0)
- 1:   pentaerythritol tetranitrate metabolic process [GO:0018954](0|0) (0|0|0)


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
(Trans)glycosidases0.000000032230.000000000005656Direct
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK0.00024890.0003918Direct
Carbamate kinase-like0.000085510Direct
Chelatase0.000085510.000002752Direct
Chorismate mutase II0.00000078960.0000000000002422Direct
Creatinase/aminopeptidase0.00032120.00000006376Direct
Dihydrofolate reductase-like0.00021320.000001741Direct
DNA polymerase III chi subunit0.00024890.0004001Direct
DNA-glycosylase0.00017280.000000002249Direct
dUTPase-like0.000012530.0003639Direct
Glutaminase/Asparaginase0.000025750.0001564Direct
HRDC-like0.0002710Direct
Indolic compounds 2,3-dioxygenase-like00Direct
Inhibitor of apoptosis (IAP) repeat0.0000041770.00004203Direct
L30e-like0.0000012740.00000005942Direct
Molybdopterin synthase subunit MoaE0.0000016050.0000000000001202Direct
N-(deoxy)ribosyltransferase-like0.0000041770.00002579Direct
NadA-like00Direct
Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT)0.00000078960.000001532Direct
Nucleic acid-binding proteins0.00070950Direct
Nucleoside diphosphate kinase, NDK0.0000000000013050.000000003203Direct
Nucleoside hydrolase0.000020720.0005352Direct
Nucleotide-diphospho-sugar transferases0.00000052740.00000000000009208Direct
Nudix0.0000000038070.000000000002576Direct
Oligosaccharyltransferase subunit ost4p0.0002440.0008868Direct
Pectin lyase-like0.00029020.000229Direct
Peptide deformylase0.000059260.00001407Direct
Phospholipase A2, PLA20.000011160.0002847Direct
Protein kinase-like (PK-like)0.0000000011660Direct
Protein prenylyltransferase0.0000019290.00000001868Direct
Putative cyclase00.000000000005328Direct
Ribonuclease H-like0.000000045150.0000000007637Direct
Ribulose-phoshate binding barrel00Direct
Rnp2-like0.000091670.000004294Direct
S-adenosylmethionine decarboxylase0.00000056410.0000003792Direct
Sialidases0.0000033310.0003133Direct
Tetrahydrobiopterin biosynthesis enzymes-like0.00067810.0000005954Direct
ThiG-like0.00032120.000551Direct
Thymidylate synthase/dCMP hydroxymethylase0.0000020020.0000003234Direct
Triosephosphate isomerase (TIM)0.0001290.000009156Direct
UBC-like00Direct
Uracil-DNA glycosylase-like0.000000066240.000000000002356Direct
YutG-like0.000059260.0001005Direct
Zn-binding ribosomal proteins0.000062310.00001235Direct
Undecaprenyl diphosphate synthase0.0010970.0001564Inherited
Carbohydrate phosphatase0.23010.5372Inherited
Dehydroquinate synthase-like11Inherited
Purine and uridine phosphorylases0.076130.5317Inherited
LeuD/IlvD-like0.66890.003286Inherited
AraD/HMP-PK domain-like0.061320.6859Inherited
Chorismate lyase-like0.0012340.01333Inherited
Aconitase iron-sulfur domain0.79650.01404Inherited
Gamma-glutamyl cyclotransferase-like0.51260.9128Inherited
ISP domain0.66891Inherited
Riboflavin kinase-like0.79650.7998Inherited
Formyltransferase0.015990.000002217Inherited
DNA topoisomerase IV, alpha subunit0.0010370.000004002Inherited
Pseudouridine synthase0.0052940.0000001443Inherited
alpha/beta knot0.0091560.4651Inherited
Sm-like ribonucleoproteins0.0014210.0005831Inherited
HemD-like0.0019820.002227Inherited
His-Me finger endonucleases0.0240.0001252Inherited
IHF-like DNA-binding proteins0.05810.1021Inherited
Macro domain-like0.03850.03593Inherited
N-acetylmuramoyl-L-alanine amidase-like0.035410.3081Inherited
Metallo-hydrolase/oxidoreductase11Inherited
SAICAR synthase-like0.026141Inherited
Molybdenum cofactor biosynthesis proteins0.035970.0138Inherited
LmbE-like0.42860.4911Inherited
Metallo-dependent phosphatases0.5250.2028Inherited
Terpenoid synthases0.00046320.02061Inherited
OMPA-like0.63681Inherited
Glycerol-3-phosphate (1)-acyltransferase0.0034190.00000000004184Inherited
The spindle assembly checkpoint protein mad20.14530.02051Inherited
Translin0.27220.458Inherited
FMN-binding split barrel0.93941Inherited
Ribokinase-like0.16160.3824Inherited
DNA/RNA polymerases10.00005016Inherited
beta-lactamase/transpeptidase-like0.62320.0083Inherited
Aquaporin-like11Inherited
RNI-like11Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.000037580.001395Inherited
Cytochrome P45011Inherited
Lipocalins0.97271Inherited
MAPEG domain-like0.017030.04611Inherited
Thioredoxin-like11Inherited
Xylose isomerase-like0.23260.2093Inherited
HD-domain/PDEase-like10.05364Inherited
FMN-linked oxidoreductases11Inherited
Metallo-dependent hydrolases0.0069170.07477Inherited
Cytidine deaminase-like0.093920.2007Inherited
RmlC-like cupins11Inherited
Metallothionein11Inherited
Isocitrate/Isopropylmalate dehydrogenase-like0.013490.1396Inherited
FabD/lysophospholipase-like0.73081Inherited
ClpP/crotonase0.000050450.001552Inherited
PLC-like phosphodiesterases0.32760.9339Inherited
Phosphoenolpyruvate/pyruvate domain10.7946Inherited
alpha/beta-Hydrolases11Inherited
Adenine nucleotide alpha hydrolases-like10.9945Inherited
Lysozyme-like10.3511Inherited
RING/U-box0.0043220Inherited
Ubiquitin-like10.9276Inherited
Malate synthase G0.0018140.001244Inherited
Dihydropteroate synthetase-like0.011750.0000004026Inherited
CoA-transferase family III (CaiB/BaiF)0.050310.8016Inherited
Apolipoprotein A-II0.0012340.001941Inherited
(Phosphotyrosine protein) phosphatases II0.98020.01412Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.010811Inherited
4-helical cytokines11Inherited
Phospholipase D/nuclease0.0002710.01499Inherited
Class II aaRS and biotin synthetases0.20810.00000001939Inherited
Ribosomal protein L10-like0.53270.1314Inherited
"Winged helix" DNA-binding domain10.9503Inherited
FAD/NAD(P)-binding domain11Inherited
ADC synthase0.091420.09955Inherited
Ferritin-like11Inherited
ADP-ribosylglycohydrolase0.0039420.01848Inherited
DHS-like NAD/FAD-binding domain0.011930.03076Inherited
Phosphotyrosine protein phosphatases I0.11320.2417Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.00020671Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.43621Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.009290.00004092Inherited
RBP11-like subunits of RNA polymerase0.00000054370.001016Inherited
RNA polymerase subunits0.011930.009184Inherited
RNA polymerase subunit RPB100.0010970.00438Inherited
RPB6/omega subunit-like0.052740.1021Inherited
SIS domain0.30060.00007899Inherited
Ribosomal protein S70.069150.0005082Inherited
Ribosomal proteins L15p and L18e0.098450.00403Inherited
Translation proteins SH3-like domain0.016680.00000006431Inherited
Ribosomal protein L140.0079330.02652Inherited
Ribosomal protein S60.00087450.003172Inherited
Ribosomal protein L30p/L7e0.017870.01039Inherited
Ribosomal protein L31e0.0057550.009016Inherited
Ribosomal proteins S24e, L23 and L15e0.089260.01117Inherited
Ribosome recycling factor, RRF0.0043130.01957Inherited
RL5-like0.0034240.006336Inherited
Translation proteins0.047470.004347Inherited
Ribosomal protein S5 domain 2-like0.0076650.000000003723Inherited
Ribosomal protein L200.04290.0892Inherited
Ribosomal protein S80.016040.03566Inherited
Ribosomal protein L130.035970.03605Inherited
Ribosomal protein S100.11710.002101Inherited
L28p-like0.10420.00541Inherited
Ribosomal protein S190.10420.2064Inherited
Translational machinery components0.2940.0007732Inherited
Ribosomal protein L10.10270.01109Inherited
Alpha-L RNA-binding motif0.30690.000009736Inherited
Ribosomal protein S160.0014020.007826Inherited
eIF1-like0.4440.1045Inherited
SRF-like0.065611Inherited
Mediator hinge subcomplex-like0.18820.2793Inherited
FMN-dependent nitroreductase-like0.68791Inherited
Trypsin-like serine proteases0.0015170.0000006022Inherited
Aromatic compound dioxygenase0.26611Inherited
Acetyl-CoA synthetase-like0.39991Inherited
ACP-like0.39181Inherited
Thioesterase/thiol ester dehydrase-isomerase0.95450.5044Inherited
2-methylcitrate dehydratase PrpD0.80470.9696Inherited
Histone-fold11Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.71721Inherited
Mss4-like11Inherited
Peptide methionine sulfoxide reductase0.041240.7097Inherited
Periplasmic binding protein-like II11Inherited
PFL-like glycyl radical enzymes0.97930.6804Inherited
P-loop containing nucleoside triphosphate hydrolases11Inherited
CYTH-like phosphatases0.27280.6946Inherited
HybD-like0.017870.02707Inherited
Aldolase0.000044330.0104Inherited
NagB/RpiA/CoA transferase-like0.087141Inherited
NAD kinase/diacylglycerol kinase-like0.00070321Inherited
Phosphofructokinase0.000013020.8421Inherited
Phosphoglycerate kinase11Inherited
Phosphoglycerate mutase-like11Inherited
Ribose/Galactose isomerase RpiB/AlsB0.46850.6683Inherited
Trimeric LpxA-like enzymes11Inherited
Snake toxin-like10Inherited
Activating enzymes of the ubiquitin-like proteins0.0053760.316Inherited
Cyclophilin-like0.61290.0689Inherited
Zn-dependent exopeptidases0.40570.001709Inherited
Clavaminate synthase-like0.88350.1927Inherited
CSL zinc finger0.0083110.05449Inherited
Acyl-CoA N-acyltransferases (Nat)0.09750.000002744Inherited
Cystine-knot cytokines10.2186Inherited
PIN domain-like10.0001926Inherited
RNA-binding domain, RBD0.75390.2851Inherited
Calcium-dependent phosphotriesterase0.11621Inherited
Chorismate synthase, AroC0.0036610.009016Inherited
Cysteine proteinases0.17810.000000721Inherited
S15/NS1 RNA-binding domain0.035970.00000000001167Inherited
Concanavalin A-like lectins/glucanases11Inherited
EPT/RTPC-like0.010810.03355Inherited
Six-hairpin glycosidases0.98390.3278Inherited
Family A G protein-coupled receptor-like11Inherited
ITPase-like11Inherited
all-alpha NTP pyrophosphatases0.55360.08764Inherited
Cytochrome c oxidase subunit I-like11Inherited
Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)0.00024890.7539Inherited
Mitochondrial cytochrome c oxidase subunit IV11Inherited
Cytochrome c oxidase subunit h0.66890.8478Inherited
Cytochrome c11Inherited
Epsilon subunit of mitochondrial F1F0-ATP synthase0.027940.04171Inherited
ATP synthase (F1-ATPase), gamma subunit0.66890.6683Inherited
F1F0 ATP synthase subunit C0.097011Inherited
Fumarate reductase respiratory complex transmembrane subunits11Inherited
Nqo5-like11Inherited
Inosine monophosphate dehydrogenase (IMPDH)0.51260.2785Inherited
HIT-like0.091540.0002637Inherited
CoaB-like0.20340.01267Inherited
Isochorismatase-like hydrolases0.44950.4516Inherited
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0.46850.3587Inherited
HydA/Nqo6-like0.51261Inherited
HydB/Nqo4-like0.56071Inherited
Alkaline phosphatase-like11Inherited
Ribonuclease Rh-like0.0036610.01295Inherited
RelE-like0.13940.1959Inherited
ARM repeat11Inherited
4'-phosphopantetheinyl transferase0.011750.5297Inherited
WD40 repeat-like11Inherited
NAD(P)-linked oxidoreductase11Inherited
Oxysterol-binding protein-like0.82551Inherited
tRNA-guanine transglycosylase0.0036610.0004455Inherited
MTH1598-like0.0057550.009016Inherited
Hypothetical protein PH16020.0021030.001093Inherited
YaeB-like0.50470.3109Inherited
PHP domain-like0.04290.3587Inherited
Immunoglobulin0.00000000005181Inherited
UROD/MetE-like0.032210.007416Inherited
Tetrapyrrole methylase0.00031850.002667Inherited
Coproporphyrinogen III oxidase11Inherited
Mitochondrial carrier11Inherited
ApbE-like0.15060.7097Inherited
YrdC/RibB0.48480.4911Inherited
Radical SAM enzymes0.0000041780.002208Inherited
MFS general substrate transporter11Inherited
RNase A-like0.00015810.00341Inherited
Citrate synthase0.52380.1005Inherited
NAD(P)-binding Rossmann-fold domains0.52871Inherited
Acyl-CoA binding protein0.19590.382Inherited
Arginase/deacetylase0.063270.00236Inherited
FAD-linked oxidoreductase0.0057550.00002099Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.031880.07671Inherited
Homocysteine S-methyltransferase0.00065870.6753Inherited
ACT-like0.0043130.01009Inherited
D-aminoacid aminotransferase-like PLP-dependent enzymes0.091420.1289Inherited
Nucleotidylyl transferase0.01910.08378Inherited
L-aspartase-like0.28750.641Inherited
PLP-dependent transferases0.00024770.001565Inherited
Pentein0.18990.1376Inherited
Caspase-like0.02660.5068Inherited
Acid proteases0.027520.07524Inherited
Metalloproteases ("zincins"), catalytic domain0.4520.000000009313Inherited
Galactose-binding domain-like10.001137Inherited
SET domain0.93030Inherited
PP2C-like11Inherited
GckA/TtuD-like0.011760.01848Inherited
Casein kinase II beta subunit0.66890.7097Inherited
Interleukin 8-like chemokines11Inherited
LexA/Signal peptidase0.000046660.4504Inherited
Terpenoid cyclases/Protein prenyltransferases0.0000000018070.1364Inherited
Release factor0.054750.006123Inherited
eIF4e-like11Inherited
NTF2-like11Inherited
Homeodomain-like11Inherited
NAP-like0.72051Inherited
TFB5-like0.04290.06164Inherited
Cu,Zn superoxide dismutase-like11Inherited
Restriction endonuclease-like10.000285Inherited
DNA breaking-rejoining enzymes0.20340.000463Inherited
DNase I-like0.074970.09408Inherited
PRTase-like00.004695Inherited
Leucine zipper domain0.065611Inherited
Tudor/PWWP/MBT0.035970.000000000002983Inherited
2Fe-2S ferredoxin-like0.90481Inherited
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase10.1513Inherited
HAD-like0.10421Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.068360.1041Inherited
Galactose mutarotase-like10.0894Inherited
RbsD-like0.015990.02368Inherited
MoaD/ThiS0.052710.1376Inherited
Arabinanase/levansucrase/invertase0.54490.8121Inherited
Class I glutamine amidotransferase-like0.000098830.03637Inherited
ALDH-like0.11350.3272Inherited


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
(Glycosyl)asparaginase0.0000040610.0003278Direct
(Uracil-5-)-methyltransferase00.00001061Direct
1,3-glucuronyltransferase0.00023050.00000175Direct
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB0.0003920.0002099Direct
5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)0.0000000030870.000000001874Direct
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK0.0003920.0005969Direct
AD-003 protein-like0.000017960.00002431Direct
Adenosine/AMP deaminase0.000000082770.00000002236Direct
ADP-heptose LPS heptosyltransferase II0.0000000081880.000000114Direct
AlkB-like0.00000085870.000003118Direct
Arginase-like amidino hydrolases0.000000022740.000002984Direct
Arginine methyltransferase0.000000000034790Direct
Bacterial tryptophan 2,3-dioxygenase00Direct
Bee venom hyaluronidase0.0000000055540Direct
beta 1,4 galactosyltransferase (b4GalT1)0.00000017050.000000001131Direct
beta-glycanases0.000000055780.000002918Direct
Biotin biosynthesis protein BioH00Direct
Biotin synthase0.000058310.00002515Direct
BM-002-like0.00000047440.0000006471Direct
C5 cytosine-specific DNA methylase, DCM0.00010280Direct
CAF1-like ribonuclease0.00000060550.00000002889Direct
Class I DAHP synthetase0.0000076430.000008438Direct
Class I glutamine amidotransferases (GAT)0.0000000050970.0001464Direct
Creatinase/aminopeptidase0.00059470.0000006852Direct
Cytidine deaminase0.00017940.000008006Direct
D-ribulose-5-phosphate 3-epimerase0.00001620.000007537Direct
Decarboxylase0.000000000031680.000000000001607Direct
Dihydrofolate reductases0.0006320.00009332Direct
Dihydroorotase0.00057060.0007308Direct
DNA gyrase/MutL, N-terminal domain00Direct
DNA polymerase III chi subunit0.0003920.0005028Direct
DnaQ-like 3'-5' exonuclease0.0000086640Direct
dTDP-sugar isomerase0.0000018270.0000006471Direct
dUTPase-like0.000055130.0008691Direct
Enolase-phosphatase E10.000047790.0002439Direct
Exostosin00.00000000000753Direct
Ferrochelatase00.000000793Direct
Galacturonase0.000000000000045220Direct
glucose-1-phosphate thymidylyltransferase0.0000058640.0000000002666Direct
Glutaminase/Asparaginase0.000057460.0003187Direct
Glycine N-methyltransferase0.0000070070.000002464Direct
Glycogenin0.0000048510.0000003776Direct
Glycosyl transferases group 100Direct
Histamine methyltransferase0.000000031880.00000004392Direct
IF2B-like0.000087050.00000001735Direct
Inhibitor of apoptosis (IAP) repeat0.000013970.0001473Direct
Ketopantoate hydroxymethyltransferase PanB0.000057460.00002347Direct
L30e/L7ae ribosomal proteins0.00000016650.00000193Direct
Leucine carboxy methyltransferase Ppm10.00010280.00001822Direct
MioX-like0.000057460.0002357Direct
MoaD0.000026880.00003551Direct
Molybdenum cofactor biosynthesis protein MobA00.0001339Direct
Molybdenum cofactor biosynthesis protein MoeB0.00000000000022050.0000000000002993Direct
Molybdopterin synthase subunit MoaE0.0000054710.0000000000006434Direct
Mug-like0.000017960.00003269Direct
MutT-like0.0000035960.00000007346Direct
Mycolic acid cyclopropane synthase00.000001465Direct
N-deoxyribosyltransferase0.0001660.0002166Direct
NadA-like00Direct
NagB-like0.0000028210.000003217Direct
Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT)0.0000018270.000002464Direct
Nuclease0.000047790.0002357Direct
Nucleoside diphosphate kinase, NDK0.000000000035380.00000002601Direct
Nucleoside hydrolase0.000053940.0005859Direct
Nucleotide and nucleoside kinases0.000093030.00003668Direct
Outer membrane enzyme PagP00Direct
Oxygen-independent coproporphyrinogen III oxidase HemN0.000000000000026180.0000000000001893Direct
Pancreatic lipase, N-terminal domain0.00000000024170.0000001028Direct
PdxA-like00Direct
Pectin lyase0.0000000000006760.00000000000002276Direct
Peptide deformylase0.00010280.00002347Direct
Phosphoserine phosphatase0.000047790.0000533Direct
Protein kinases, catalytic subunit0.0000000003920Direct
Protein prenyltransferases0.00000000056930.0000000000003617Direct
Protein prenylyltransferase0.0000052280.0000000009729Direct
Pseudouridine synthase RsuA/RluD00.000007895Direct
Putative cyclase00.000000000000005999Direct
PyrH-like0.00010280.000000000002914Direct
Pyridoxal-dependent decarboxylase0.00044930.000000005654Direct
RBP11/RpoL0.000018640.00007216Direct
RBP12 subunit of RNA polymerase II0.00059470.0007641Direct
RING finger domain, C3HC40.00074630Direct
RNA methyltransferase FtsJ0.000057460.000006714Direct
RNA polymerase II subunit RBP4 (RpoF)0.00054110.000005773Direct
rRNA adenine dimethylase-like0.00037350.0001808Direct
rRNA methyltransferase RlmA00Direct
S-adenosylmethionine decarboxylase0.000058310.00007216Direct
Sialidases (neuraminidases)0.0000000019310.0000001342Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.00000031160.000000000004589Direct
Spermidine synthase0.00000030960.000001777Direct
SpoU-like RNA 2'-O ribose methyltransferase0.00010280.0006103Direct
Squalene synthase00.000000007948Direct
Thiamin biosynthesis kinases0.0000038340.0000002663Direct
ThiG-like0.0001660.0002166Direct
Thymidylate synthase/dCMP hydroxymethylase0.0000058640.000000793Direct
Triosephosphate isomerase (TIM)0.00045710.00002435Direct
TrmB-like0.00000056040.0000007781Direct
Tryptophan biosynthesis enzymes0.00013390.00001302Direct
Type 1 signal peptidase0.0003920.00007628Direct
UBC-related00Direct
Ubiquitin activating enzymes (UBA)0.000000033660Direct
Ubiquitin carboxyl-terminal hydrolase, UCH00Direct
Ubiquitin-related00Direct
UFC1-like0.00018630.0002439Direct
Vertebrate phospholipase A20.000029790.0008691Direct
YutG-like0.00010280.0001339Direct
NagD-like0.1780.1531Inherited
Undecaprenyl diphosphate synthase0.0018420.0001859Inherited
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0.25650.5144Inherited
Glyoxalase II (hydroxyacylglutathione hydrolase)0.55940.7736Inherited
Glyoxalase I (lactoylglutathione lyase)0.062050.0008374Inherited
Iron-containing alcohol dehydrogenase11Inherited
Purine and uridine phosphorylases0.071340.5352Inherited
Serine acetyltransferase0.0063141Inherited
LeuD-like0.63360.008975Inherited
Acireductone dioxygenase0.00029630.002503Inherited
AraD-like aldolase/epimerase0.11960.7717Inherited
HMGL-like0.25660.6168Inherited
Cutinase-like0.13450.159Inherited
Gamma-glutamyl cyclotransferase-like0.48350.6122Inherited
V set domains (antibody variable domain-like)01Inherited
Arylamine N-methyltransferase0.87261Inherited
ATP-dependent riboflavin kinase-like0.75570.7409Inherited
6-pyruvoyl tetrahydropterin synthase0.0012910.001654Inherited
Dihydropteroate synthetase0.0056090.008589Inherited
Methenyltetrahydrofolate synthetase0.062050.0529Inherited
Endonuclease I0.0014890.0005028Inherited
DNA topoisomerase IV, alpha subunit0.0014890.00000711Inherited
3-Methyladenine DNA glycosylase I (Tag)0.0050070.01083Inherited
DNase I-like0.0014120.00002636Inherited
Uroporphyrinogen decarboxylase, UROD0.0004590.004658Inherited
HemD-like0.012470.02426Inherited
Prokaryotic DNA-bending protein0.08580.09795Inherited
Rieske iron-sulfur protein (ISP)0.02031Inherited
Spore coat polysaccharide biosynthesis protein SpsA0.012470.0208Inherited
Macro domain0.030050.1094Inherited
Cytidylytransferase0.0000076430.002881Inherited
N-acetylmuramoyl-L-alanine amidase-like0.05880.4018Inherited
Inositol polyphosphate kinase (IPK)0.057020.0002896Inherited
MogA-like0.02030.2767Inherited
MoCo biosynthesis proteins0.028420.002262Inherited
Formyltransferase0.023560.000007895Inherited
Ribonucleotide reductase-like0.015730.0000001324Inherited
SAICAR synthase0.0001660.001441Inherited
Ribokinase-like0.41280.756Inherited
Isoprenyl diphosphate synthases00.003696Inherited
The spindle assembly checkpoint protein mad20.2150.01644Inherited
Translin0.30910.4571Inherited
Thioltransferase11Inherited
PfkB-like kinase0.0050070.002579Inherited
PNP-oxidase like0.40310.5727Inherited
Adenylyltransferase0.00013470.3402Inherited
PdxS-like0.002010.002579Inherited
C1 set domains (antibody constant domain-like)0.92381Inherited
beta-Lactamase/D-ala carboxypeptidase0.6450.03042Inherited
Aquaporin-like11Inherited
Proteasome subunits0.013380.02051Inherited
Cyclin A/CDK2-associated p19, Skp20.0045230.0002815Inherited
LmbE-like0.042280.1601Inherited
Cytochrome P45011Inherited
Retinol binding protein-like11Inherited
MAPEG domain0.0071220.01487Inherited
Hypothetical esterase YJL068C0.0026790.003412Inherited
FMN-linked oxidoreductases11Inherited
Family 1 of glycosyl hydrolase0.010750.1531Inherited
alpha-1,3-galactosyltransferase-like0.0092790.0000002675Inherited
IPP isomerase-like0.02780.001833Inherited
Metallothionein11Inherited
Crotonase-like0.004130.006834Inherited
Glycerophosphoryl diester phosphodiesterase0.48350.3633Inherited
Phosphoenolpyruvate mutase/Isocitrate lyase-like0.97431Inherited
Carbon-carbon bond hydrolase0.0012910.003412Inherited
Fatty acid binding protein-like0.09390.2Inherited
ETFP subunits0.40310.719Inherited
Glycerol-3-phosphate transporter0.90981Inherited
APC10-like0.061290.0003187Inherited
Penicillin synthase-like0.48120.7036Inherited
Malate synthase G0.0036580.001933Inherited
CoA-transferase family III (CaiB/BaiF)0.097040.8696Inherited
Apolipoprotein A-II0.0019150.002422Inherited
Hydrogenase maturating endopeptidase HybD0.0055770.006971Inherited
Hypoxia-inducible factor HIF ihhibitor (FIH1)0.030050.02186Inherited
Dual specificity phosphatase-like0.84570.5955Inherited
NLI interacting factor-like phosphatase0.000980.08375Inherited
Glutaminyl-peptide cyclotransferase-like0.016350.0000002675Inherited
Ribosomal protein S27e0.006840.008589Inherited
Interferons/interleukin-10 (IL-10)11Inherited
Ribosomal protein S40.032960.2136Inherited
ADC synthase0.085720.08375Inherited
Indoleamine 2,3-dioxygenase-like0.000047790.007844Inherited
Aristolochene/pentalenene synthase0.0018420.02732Inherited
Mitochondrial carrier11Inherited
Thioesterases0.40310.538Inherited
ADP-ribosylglycohydrolase0.006840.02426Inherited
Sir2 family of transcriptional regulators0.013930.02322Inherited
Low-molecular-weight phosphotyrosine protein phosphatases0.16630.2909Inherited
Branched-chain alpha-keto acid dehydrogenase PP module0.00037351Inherited
PIN domain0.95991Inherited
RNA-polymerase beta0.0043780.001148Inherited
RNA polymerase subunit RBP80.0092790.01156Inherited
RNA polymerase subunit RPB100.0018420.005683Inherited
RPB60.019640.03685Inherited
mono-SIS domain0.11380.01924Inherited
Probable phosphatase YrbI0.02780.9322Inherited
Ribosomal protein S70.11340.001096Inherited
Ribosomal protein L30p/L7e0.02780.04079Inherited
Translational machinery components0.042750Inherited
Ribosomal protein L31e0.0092790.01156Inherited
Ribosome recycling factor, RRF0.0056090.02732Inherited
Ribosomal protein L50.0070790.009756Inherited
Ribosomal protein L33p0.062050.03685Inherited
Ribosomal protein L14e0.02030.00131Inherited
Ribosomal protein S80.030460.04994Inherited
Ribosomal proteins L15p and L18e0.15140.008478Inherited
L15e0.039660.04806Inherited
Ribosomal protein L35ae0.02780.03404Inherited
Ribosomal protein L200.061290.1052Inherited
Ribosomal protein L140.015730.03763Inherited
Ribosomal protein L10.14630.03226Inherited
Ribosomal protein L130.045940.05417Inherited
Ribosomal protein S100.15920.003688Inherited
Ribosomal proteins L24p and L21e0.15920.08751Inherited
Ribosomal protein L18 and S110.40680.009084Inherited
Ribosomal protein S24e0.12120.1431Inherited
Ribosomal protein L10-like0.12960.00001909Inherited
Ribosomal protein S190.12960.2512Inherited
L23p0.74730.1637Inherited
Ribosomal protein S160.0026790.01083Inherited
Ribosomal protein S60.0015870.004658Inherited
Transferrin0.0045230.02585Inherited
Galactosyltransferase LgtC0.12960.6525Inherited
Rps19E-like0.019640.01083Inherited
Cold shock DNA-binding domain-like0.013190.000000005842Inherited
eIF1-like0.50790.08751Inherited
SRF-like0.045941Inherited
Gtf glycosyltransferase0.90620.9341Inherited
NADH oxidase/flavin reductase0.66891Inherited
Eukaryotic proteases0.010290.000007872Inherited
PhyH-like0.0026790.003412Inherited
UDPGT-like0.29410.6172Inherited
Acetyl-CoA synthetase-like0.39021Inherited
MaoC-like0.54940.0003638Inherited
2-methylcitrate dehydratase PrpD0.76620.9085Inherited
LplA-like0.44130.279Inherited
Biotin dependent carboxylase carboxyltransferase domain0.0055770.02844Inherited
Peptide methionine sulfoxide reductase0.062050.6525Inherited
SelR domain0.66890.7133Inherited
N-type ATP pyrophosphatases0.44820.03728Inherited
CYTH domain0.15920.8353Inherited
NAD kinase-like0.0050070.000001364Inherited
Class I aldolase0.63460.3929Inherited
Dimeric isocitrate & isopropylmalate dehydrogenases0.0078230.03974Inherited
Phosphofructokinase0.000039440.7735Inherited
Phosphoglycerate kinase11Inherited
Cofactor-dependent phosphoglycerate mutase0.38840.8626Inherited
Ribose/Galactose isomerase RpiB/AlsB0.44130.6122Inherited
Class II FBP aldolase0.091630.1354Inherited
Aromatic compound dioxygenase0.3661Inherited
Long-chain cytokines11Inherited
Cyclophilin (peptidylprolyl isomerase)0.78680.05332Inherited
CSL zinc finger0.012470.07117Inherited
N-acetyl transferase, NAT0.26140.000003976Inherited
TBP-associated factors, TAFs0.37410.6976Inherited
Nucleosome core histones11Inherited
Canonical RBD0.80410.207Inherited
U2A'-like0.12960.2857Inherited
spliceosomal protein U5-15Kd0.49960.5617Inherited
Shikimate kinase (AroK)0.000047790.001017Inherited
Dehydroquinate synthase, DHQS0.0056090.01156Inherited
SGL-like0.12520.2014Inherited
Chorismate synthase, AroC0.0055770.01156Inherited
Trehalose-6-phosphate synthase, OtsA0.0026790.005666Inherited
UDP-N-acetylglucosamine 2-epimerase0.0019150.003412Inherited
Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)0.48350.6525Inherited
Papain-like0.21740.008423Inherited
Xylanase/endoglucanase 11/120.0022550.007695Inherited
Hydroxynitrile lyase-like0.00078330.001933Inherited
Enolpyruvate transferase, EPT0.013930.01353Inherited
Rhodopsin-like11Inherited
ITPase (Ham1)0.23820.2767Inherited
Cytochrome c oxidase subunit I-like11Inherited
Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)0.0003920.6956Inherited
Mitochondrial cytochrome c oxidase subunit IV11Inherited
monodomain cytochrome c11Inherited
Epsilon subunit of mitochondrial F1F0-ATP synthase0.042750.05186Inherited
ATP synthase (F1-ATPase), gamma subunit0.63360.6122Inherited
F1F0 ATP synthase subunit C0.12711Inherited
Nq06-like0.66890.6956Inherited
Nqo4-like0.64290.6122Inherited
Nqo5-like11Inherited
Histidine acid phosphatase11Inherited
Inosine monophosphate dehydrogenase (IMPDH)0.48770.2982Inherited
HIT (HINT, histidine triad) family of protein kinase-interacting proteins0.22740.1928Inherited
PAPS sulfotransferase11Inherited
CoaB-like0.24580.01737Inherited
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0.44130.3184Inherited
Isochorismatase-like hydrolases0.5870.5559Inherited
Nitrogenase iron protein-like11Inherited
DJ-1/PfpI0.52580.718Inherited
Oligosaccharyltransferase subunit ost4p0.00059690.001441Inherited
Arylsulfatase11Inherited
Ribonuclease Rh-like0.0055770.01999Inherited
Phosphoribulokinase/pantothenate kinase0.049990.279Inherited
Aldo-keto reductases (NADP)11Inherited
Oxysterol-binding protein0.88141Inherited
tRNA(1-methyladenosine) methyltransferase-like0.0014890.0007308Inherited
Rpp14/Pop5-like0.0018420.00007771Inherited
tRNA-guanine transglycosylase0.0055770.0007929Inherited
MTH1598-like0.0092790.01156Inherited
Hypothetical protein PH16020.0044590.001833Inherited
YaeB-like0.56960.3552Inherited
RNase Z-like0.31050.00115Inherited
Deoxycytidylate deaminase-like0.3730.01118Inherited
NOL1/NOP2/sun0.0003920.02074Inherited
Tetrapyrrole methylase0.00081930.005473Inherited
Coproporphyrinogen III oxidase11Inherited
ApbE-like0.082780.6525Inherited
Gonadodropin/Follitropin11Inherited
Ribonuclease A-like0.00087580.008097Inherited
Citrate synthase0.49760.08298Inherited
Holo-(acyl carrier protein) synthase ACPS0.045940.004658Inherited
Acyl-CoA binding protein0.26480.3402Inherited
Serum paraoxonase/arylesterase 1, PON10.0045230.1351Inherited
STAR domain0.24580.2265Inherited
GABA-aminotransferase-like0.0061890.07737Inherited
Glutathione peroxidase-like11Inherited
Proline dehydrohenase domain of bifunctional PutA protein0.0055770.0009407Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.030440.06088Inherited
Glycine dehydrogenase subunits (GDC-P)0.0019150.00001604Inherited
Dimethylarginine dimethylaminohydrolase DDAH0.0015870.002022Inherited
Renal dipeptidase0.13540.2287Inherited
BadF/BadG/BcrA/BcrD-like0.0003920.6122Inherited
HAL/PAL-like11Inherited
Homocysteine S-methyltransferase0.0012910.6144Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.0036380Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.006840Inherited
D-aminoacid aminotransferase-like PLP-dependent enzymes0.085720.1171Inherited
Cystathionine synthase-like0.51360.6501Inherited
L-aspartase/fumarase0.013670.04885Inherited
Ubiquitin thiolesterase protein OTUB2 (Otubain-2)0.0018420.00107Inherited
Caspase catalytic domain0.043960.1461Inherited
Neurolysin-like00.1432Inherited
Ubiquitin carboxyl-terminal hydrolase UCH-L0.030050.0000000000008022Inherited
Adenain-like0.023560Inherited
Pepsin-like0.0015480.02048Inherited
Clp protease, ClpP subunit0.23820.6122Inherited
Astacin0.58590.009084Inherited
Protein-L-isoaspartyl O-methyltransferase0.00037350.001933Inherited
G proteins11Inherited
B56-like0.80720.4144Inherited
PP2C-like11Inherited
GckA/TtuD-like0.019640.02426Inherited
Casein kinase II beta subunit0.64290.6525Inherited
Interleukin 8-like chemokines11Inherited
Short-chain cytokines0.99181Inherited
Release factor0.091630.01059Inherited
Translation initiation factor eIF4e11Inherited
WD40-repeat11Inherited
Cell cycle arrest protein BUB30.92381Inherited
NTF2-like0.99540.4578Inherited
RNA-polymerase beta-prime0.61090.02289Inherited
NAP-like0.78561Inherited
DNA repair glycosylase, 2 C-terminal domains00.00115Inherited
Endonuclease IV0.0014890.0005028Inherited
TFB5-like0.061290.07353Inherited
Uracil-DNA glycosylase0.0014890.0000008438Inherited
RecA protein-like (ATPase-domain)0.011130.07655Inherited
Cu,Zn superoxide dismutase-like11Inherited
Ribonuclease H0.00059690.1336Inherited
Single strand DNA-binding domain, SSB0.29540Inherited
Lambda integrase-like, catalytic core0.082780.1249Inherited
Endonuclease III0.082780.00002431Inherited
TatD Mg-dependent DNase-like0.64290.7795Inherited
Phosphoribosyltransferases (PRTases)0.0000000000000022720.002452Inherited
Leucine zipper domain0.082781Inherited
2Fe-2S ferredoxin-related0.88991Inherited
Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)11Inherited
Glycosyl hydrolases family 160.39680.6895Inherited
Type II chitinase0.74730.863Inherited
Aldose 1-epimerase (mutarotase)0.54940.1637Inherited
FucT-like0.86561Inherited
Tyrosine-dependent oxidoreductases0.57441Inherited
RbsD-like0.023560.02882Inherited
beta-Phosphoglucomutase-like0.030810.05046Inherited
ALDH-like0.14010.3265Inherited
C9orf74 homolog0.023560.02882Inherited
Pectate lyase-like0.00044250.002453Inherited
alpha-L-arabinanase-like0.65971Inherited
NagZ-like0.0045230.1751Inherited
Histidine biosynthesis enzymes0.0012910.00006321Inherited
AAT-like0.0019710.005924Inherited
L-histidinol dehydrogenase HisD0.0019150.0002439Inherited


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Supra-domain (including individual superfamily)

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