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Biological Process (BP): regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   biological_process [GO:0008150] <24>
+ + + + 4:   biological regulation [GO:0065007] <5>(165|190) (757|933|542)
+ + + 3:   regulation of biological process [GO:0050789] <34>(155|176) (709|883|505)
+ + + 3:   regulation of cellular process [GO:0050794] <58>(138|154) (661|802|451)
+ + 2:   regulation of cell communication [GO:0010646] <25>(42|44) (331|347|194)
+ + 2:   regulation of response to stimulus [GO:0048583] <43>(57|53) (384|420|248)
+ + 2:   regulation of signaling [GO:0023051] <13>(42|44) (331|349|197)
+ 1:   regulation of signal transduction [GO:0009966] <71>(39|40) (308|319|183)
0:   regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0090092] <9>(3|2) (55|48|44)
- 1:   negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0090101] <7>(1|1) (31|30|31)
- 1:   positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0090100] <6>(1|1) (18|14|10)
- 1:   regulation of BMP signaling pathway [GO:0030510] <5>(0|0) (32|26|20)
- 1:   regulation of transforming growth factor beta receptor signaling pathway [GO:0017015] <4>(2|2) (16|17|24)
- 1:   regulation of activin receptor signaling pathway [GO:0032925] <3>(0|0) (8|8|4)
- 1:   regulation of SMAD protein import into nucleus [GO:0060390] <2>(0|0) (4|1|0)
- 1:   regulation of decapentaplegic signaling pathway [GO:0090097] <2>(0|0) (5|4|1)
- 1:   regulation of pathway-restricted SMAD protein phosphorylation [GO:0060393] <2>(0|0) (4|1|0)
- 1:   regulation of SMAD protein complex assembly [GO:0010990] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Cystine-knot cytokines0.00000098750Direct
WD40 repeat-like0.00078161Inherited
Ankyrin repeat0.00000053250.9911Inherited


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
WD40-repeat0.00023980.7075Inherited
Ankyrin repeat0.00000025010.9524Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this GO term
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Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Cystine-knot cytokines0Direct
Alkaline phosphatase-like0Direct
Putative DNA-binding domain0Direct
FnI-like domain0Direct
Snake toxin-like0Direct
Kazal-type serine protease inhibitors0Direct
SMAD MH1 domain0Direct
SAND domain-like0.0000000000003396Direct
TB module/8-cys domain0.0000000000008107Direct
Serine protease inhibitors0.000000000047Direct
SMAD/FHA domain0.000000002136Direct
HSP90 C-terminal domain0.0000008107Direct
WW domain0.000001188Direct
Hedgehog/intein (Hint) domain0.000002208Direct
Hedgehog/DD-peptidase0.000002208Direct
Frizzled cysteine-rich domain0.000003202Direct
TIMP-like0.000007778Direct
Homeodomain-like0.00005412Direct
Thyroglobulin type-1 domain0.00005974Direct
Growth factor receptor domain0.00007213Direct
BAR/IMD domain-like0.00008256Direct
Periplasmic binding protein-like I0.0005423Direct
Notch domain0.0006769Direct
PX domain0.0007074Direct
LEM domain0.0007606Direct
p53-like transcription factors0.04906Inherited
Voltage-gated potassium channels0.001175Inherited
Cysteine-rich domain0.6299Inherited
lambda repressor-like DNA-binding domains0.002484Inherited
PDZ domain-like0.0377Inherited
HAD-like0.009692Inherited
Bromodomain0.1142Inherited
CAD & PB1 domains0.09522Inherited
Trypsin-like serine proteases0.1578Inherited
HIT/MYND zinc finger-like0.003811Inherited
RNI-like0.01889Inherited
F-box domain0.003001Inherited
HLH, helix-loop-helix DNA-binding domain0.1959Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.005844Inherited
Ribosomal protein S5 domain 2-like0.0145Inherited
beta-beta-alpha zinc fingers0.2394Inherited
E set domains0.1845Inherited
TSP-1 type 1 repeat0.002501Inherited
Ubiquitin-like0.8841Inherited
Protein kinase-like (PK-like)1Inherited
FabD/lysophospholipase-like0.109Inherited
FYVE/PHD zinc finger0.5168Inherited
EGF/Laminin0.01078Inherited
Concanavalin A-like lectins/glucanases0.7724Inherited
WD40 repeat-like0.9634Inherited
Blood coagulation inhibitor (disintegrin)0.0418Inherited
Tetraspanin0.3318Inherited
Ankyrin repeat0.8942Inherited
Acetyl-CoA synthetase-like0.01169Inherited
Periplasmic binding protein-like II0.01601Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0Direct
    46955,63763
  • 46955 - Putative DNA-binding domain
  • 63763 - SAND domain-like
  • 0Direct
    53649,53649
  • 53649 - Alkaline phosphatase-like
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    47473,57603
  • 47473 - EF-hand
  • 57603 - FnI-like domain
  • 0.000000000000009141Direct
    57610,47473
  • 57610 - Thyroglobulin type-1 domain
  • 47473 - EF-hand
  • 0.00000000000003013Direct
    51045,50156
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0.00000000002701Direct
    52540,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.0000000002615Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.000000004339Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.000000007909Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.000000007909Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.00000006173Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.00000009802Direct
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.0000001563Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.0000001775Direct
    100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.0000001775Direct
    100895,47473
  • 100895 - Kazal-type serine protease inhibitors
  • 47473 - EF-hand
  • 0.0000002283Direct
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.0000002762Direct
    57581,100895
  • 57581 - TB module/8-cys domain
  • 100895 - Kazal-type serine protease inhibitors
  • 0.000000291Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0000004512Direct
    57581,57581
  • 57581 - TB module/8-cys domain
  • 57581 - TB module/8-cys domain
  • 0.0000007603Direct
    100895,50494
  • 100895 - Kazal-type serine protease inhibitors
  • 50494 - Trypsin-like serine proteases
  • 0.000002141Direct
    57184,100895
  • 57184 - Growth factor receptor domain
  • 100895 - Kazal-type serine protease inhibitors
  • 0.000002141Direct
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.000002208Direct
    51206,56112
  • 51206 - cAMP-binding domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.000003523Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0.000004403Direct
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.00001231Direct
    50494,50156
  • 50494 - Trypsin-like serine proteases
  • 50156 - PDZ domain-like
  • 0.00001231Direct
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.00001367Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0.00004255Direct
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.00004276Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0001025Direct
    50156,52540
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0001835Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0002907Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.0002936Direct
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.0004499Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0006769Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.0007606Direct
    49854,57424
  • 49854 - Spermadhesin, CUB domain
  • 57424 - LDL receptor-like module
  • 0.0007606Direct
    47370,63748
  • 47370 - Bromodomain
  • 63748 - Tudor/PWWP/MBT
  • 0.003978Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.002501Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.03154Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.02691Inherited
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.03889Inherited
    81383,50978
  • 81383 - F-box domain
  • 50978 - WD40 repeat-like
  • 0.01672Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.0418Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.01082Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.002501Inherited
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.03356Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0Direct
    100895,47473,57603
  • 100895 - Kazal-type serine protease inhibitors
  • 47473 - EF-hand
  • 57603 - FnI-like domain
  • 0.000000000000009141Direct
    51045,51045,50156
  • 51045 - WW domain
  • 51045 - WW domain
  • 50156 - PDZ domain-like
  • 0.00000000002701Direct
    52540,51045,51045
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.0000000002615Direct
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000000002362Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.000000002362Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.000000003605Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00000000681Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.00000003108Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.00000006173Direct
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.0000000844Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.00000009553Direct
    57581,57581,57184
  • 57581 - TB module/8-cys domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.0000001252Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.000000196Direct
    57581,57184,57196
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0000002482Direct
    57581,100895,100895
  • 57581 - TB module/8-cys domain
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.000000291Direct
    57184,57603,82895
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.0000004435Direct
    57184,57581,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57581 - TB module/8-cys domain
  • 0.0000005393Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.0000007603Direct
    57581,57196,57184
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.000000894Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.000001216Direct
    51206,51206,56112
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.000001665Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.000001858Direct
    100895,50494,50156
  • 100895 - Kazal-type serine protease inhibitors
  • 50494 - Trypsin-like serine proteases
  • 50156 - PDZ domain-like
  • 0.000002141Direct
    57184,100895,50494
  • 57184 - Growth factor receptor domain
  • 100895 - Kazal-type serine protease inhibitors
  • 50494 - Trypsin-like serine proteases
  • 0.000002141Direct
    57196,57196,49899
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000002335Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.000004821Direct
    57581,57184,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.00001303Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00001367Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.00002026Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00004172Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00007193Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0001068Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0001205Direct
    90193,90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.0001835Direct
    50156,52540,51045
  • 50156 - PDZ domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51045 - WW domain
  • 0.0001835Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0002936Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0002936Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.0007606Direct
    49854,49854,57424
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 57424 - LDL receptor-like module
  • 0.0007606Direct
    57903,47370,63748
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 63748 - Tudor/PWWP/MBT
  • 0.003978Inherited
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.03399Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001249Inherited
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.008429Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
    Plot tree as:   Download Newick format tree:   Browsing in Tree_gateway:
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