SUPERFAMILY 1.75 HMM library and genome assignments server

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alpha/beta-Hydrolases superfamily models

A superfamily is represented by one or more models; usually there is more than one model representing the superfamily. Since each model is built to capture the whole superfamily, they are likely to be overlapping and sometimes are mostly overlapping or even redundant to each other. Also models often do not score their own seed sequence more highly than other sequences in the superfamily, so it is a mistake to think that the model represents the seed sequence.

All models are available for immediate download after obtaining a license by filling in a short online registration form. Licenses are free for academic and commercial purposes.

Plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed for each model by following the model ID link.


All 122 SUPERFAMILY models representing the alpha/beta-Hydrolases superfamily
Model ID No. of seqs Build date Seed sequence Family of seed
0046126 749 2008-09-10 d1cexa_ Cutinase-like
0046928 1010 2008-09-10 d1g66a_ Cutinase-like
0049005 563 2008-09-10 d1qoza_ Cutinase-like
0046502 3694 2008-09-10 d1ea5a_ Acetylcholinesterase-like
0048935 3929 2008-09-10 d1qe3a_ Acetylcholinesterase-like
0046718 3547 2008-09-10 d1f6wa_ Acetylcholinesterase-like
0046412 3829 2008-09-10 d1dx4a_ Acetylcholinesterase-like
0045186 1375 2005-09-08 d2bcea_ Acetylcholinesterase-like
0048126 3888 2008-09-10 d1maaa_ Acetylcholinesterase-like
0041128 1749 2005-09-08 d1mx1a_ Acetylcholinesterase-like
0046729 3774 2008-09-10 d1f8ua_ Acetylcholinesterase-like
0048675 3874 2008-09-10 d1p0ia_ Acetylcholinesterase-like
0039914 1550 2005-09-08 d1k4ya_ Acetylcholinesterase-like
0054493 4407 2010-05-31 d2pbla1 Carboxylesterase
0047600 17041 2008-09-10 d1jjfa_ Carboxylesterase
0039602 1498 2005-09-08 d1jkma_ Carboxylesterase
0048053 11338 2008-09-10 d1lzla_ Carboxylesterase
0051883 1312 2008-09-10 d2b20a2 Carboxylesterase
0047003 16156 2008-09-10 d1gkla_ Carboxylesterase
0047601 11733 2008-09-10 d1jjia_ Carboxylesterase
0046639 11086 2008-09-10 d1evqa_ Carboxylesterase
0046388 22 2008-09-10 d1dqza_ Mycobacterial antigens
0049383 7372 2008-09-10 d1sfra_ Mycobacterial antigens
0046670 10531 2008-09-10 d1f0na_ Mycobacterial antigens
0049128 5258 2008-09-10 d1r88a_ Mycobacterial antigens
0048945 17550 2008-09-10 d1qfma2 Prolyl oligopeptidase, C-terminal domain
0045756 826 2008-09-10 d1ac5a_ Serine carboxypeptidase-like
0050682 1398 2008-09-10 d1wpxa1 Serine carboxypeptidase-like
0047451 1017 2008-09-10 d1ivya_ Serine carboxypeptidase-like
0050563 888 2008-09-10 d1wht.1 Serine carboxypeptidase-like
0047078 854 2008-09-10 d1gxs.1 Serine carboxypeptidase-like
0047200 16412 2008-09-10 d1hlga_ Gastric lipase
0047764 10973 2008-09-10 d1k8qa_ Gastric lipase
0041081 1867 2005-09-08 d1mtza_ Proline iminopeptidase-like
0045851 14281 2008-09-10 d1azwa_ Proline iminopeptidase-like
0049037 17788 2008-09-10 d1qtra_ Proline iminopeptidase-like
0045984 13768 2008-09-10 d1bn7a_ Haloalkane dehalogenase
0045886 14703 2008-09-10 d1b6ga_ Haloalkane dehalogenase
0046219 2912 2008-09-10 d1cv2a_ Haloalkane dehalogenase
0036443 1250 2005-09-08 d1dina_ Dienelactone hydrolase
0046077 17404 2008-09-10 d1c4xa_ Carbon-carbon bond hydrolase
0047444 17446 2008-09-10 d1iupa_ Carbon-carbon bond hydrolase
0047495 14181 2008-09-10 d1j1ia_ Carbon-carbon bond hydrolase
0054676 9844 2010-05-31 d2rhwa1 Carbon-carbon bond hydrolase
0037013 2256 2005-09-08 d1ehya_ Epoxide hydrolase
0049001 1211 2008-09-10 d1qo7a_ Epoxide hydrolase
0050206 17201 2008-09-10 d1vj5a2 Epoxide hydrolase
0046573 13921 2008-09-10 d1ek1a2 Epoxide hydrolase
0045736 17413 2008-09-10 d1a88a_ Haloperoxidase
0046004 13446 2008-09-10 d1brta_ Haloperoxidase
0045742 13739 2008-09-10 d1a8sa_ Haloperoxidase
0047194 13512 2008-09-10 d1hkha_ Haloperoxidase
0045741 13561 2008-09-10 d1a8qa_ Haloperoxidase
0050112 13820 2008-09-10 d1va4a_ Haloperoxidase
0042339 585 2005-09-08 d1pjaa_ Thioesterases
0049631 16546 2008-09-10 d1thta_ Thioesterases
0037021 124 2005-09-08 d1ei9a_ Thioesterases
0054009 984 2010-05-31 d2h1ia1 Carboxylesterase/thioesterase 1
0054807 1757 2010-05-31 d3b5ea1 Carboxylesterase/thioesterase 1
0054656 4015 2010-05-31 d2r8ba1 Carboxylesterase/thioesterase 1
0046793 2270 2008-09-10 d1fj2a_ Carboxylesterase/thioesterase 1
0045824 17341 2008-09-10 d1auoa_ Carboxylesterase/thioesterase 1
0048982 11869 2008-09-10 d1qlwa_ A novel bacterial esterase
0039526 1682 2005-09-08 d1jfra_ Lipase
0038343 1292 2005-09-08 d1gz7a_ Fungal lipases
0046202 3481 2008-09-10 d1crla_ Fungal lipases
0050010 2859 2008-09-10 d1uwca_ Fungal lipases
0049638 2968 2008-09-10 d1tiba_ Fungal lipases
0047974 1705 2008-09-10 d1lgya_ Fungal lipases
0049630 3638 2008-09-10 d1thga_ Fungal lipases
0046169 3563 2008-09-10 d1clea_ Fungal lipases
0049928 3699 2008-09-10 d1ukca_ Fungal lipases
0049637 2389 2008-09-10 d1tiaa_ Fungal lipases
0053336 1522 2008-09-10 d3tgla_ Fungal lipases
0049591 24 2008-09-10 d1tcaa_ Fungal lipases
0047879 7116 2008-09-10 d1ku0a_ Bacterial lipase
0037239 1195 2005-09-08 d1ex9a_ Bacterial lipase
0047317 14805 2008-09-10 d1i6wa_ Bacterial lipase
0053348 14527 2008-09-10 d4lipd_ Bacterial lipase
0046221 20115 2008-09-10 d1cvla_ Bacterial lipase
0047592 6492 2008-09-10 d1ji3a_ Bacterial lipase
0043326 816 2005-09-08 d1rp1a2 Pancreatic lipase, N-terminal domain
0046624 19730 2008-09-10 d1etha2 Pancreatic lipase, N-terminal domain
0047034 19500 2008-09-10 d1gpla2 Pancreatic lipase, N-terminal domain
0046012 19939 2008-09-10 d1bu8a2 Pancreatic lipase, N-terminal domain
0047220 20202 2008-09-10 d1hpla2 Pancreatic lipase, N-terminal domain
0048008 20216 2008-09-10 d1lpbb2 Pancreatic lipase, N-terminal domain
0048965 17637 2008-09-10 d1qj4a_ Hydroxynitrile lyase-like
0051001 17593 2008-09-10 d1xkla_ Hydroxynitrile lyase-like
0046410 14249 2008-09-10 d1dwoa_ Hydroxynitrile lyase-like
0047683 19726 2008-09-10 d1ju3a2 PepX catalytic domain-like
0048003 604 2008-09-10 d1lnsa3 PepX catalytic domain-like
0048460 19636 2008-09-10 d1nx9a2 PepX catalytic domain-like
0048207 20079 2008-09-10 d1mpxa2 PepX catalytic domain-like
0048194 20249 2008-09-10 d1mnaa_ Thioesterase domain of polypeptide, polyketide and fatty acid synthases
0047627 15257 2008-09-10 d1jmkc_ Thioesterase domain of polypeptide, polyketide and fatty acid synthases
0040046 1287 2005-09-08 d1keza_ Thioesterase domain of polypeptide, polyketide and fatty acid synthases
0051009 1522 2008-09-10 d1xkta_ Thioesterase domain of polypeptide, polyketide and fatty acid synthases
0047388 15702 2008-09-10 d1imja_ Ccg1/TafII250-interacting factor B (Cib)
0048633 17741 2008-09-10 d1orva2 DPP6 catalytic domain-like
0041193 1289 2005-09-08 d1n1ma2 DPP6 catalytic domain-like
0050947 3010 2008-09-10 d1xfda2 DPP6 catalytic domain-like
0050245 19775 2008-09-10 d1vlqa_ Acetyl xylan esterase-like
0047940 19853 2008-09-10 d1l7aa_ Acetyl xylan esterase-like
0048075 16583 2008-09-10 d1m33a_ Biotin biosynthesis protein BioH
0049887 23462 2008-09-10 d1ufoa_ Hypothetical protein TT1662
0042551 2469 2005-09-08 d1q0ra_ Aclacinomycin methylesterase RdmC
0049087 21222 2008-09-10 d1r1da_ Carboxylesterase/lipase
0044560 576 2005-09-08 d1uxoa_ YdeN-like
0050226 13743 2008-09-10 d1vkha_ Putative serine hydrolase Ydr428c
0053045 18843 2008-09-10 d2hu7a2 Acylamino-acid-releasing enzyme, C-terminal donain
0048825 895 2008-09-10 d1pv1a_ Hypothetical esterase YJL068C
0049094 5420 2008-09-10 d1r3da_ Hypothetical protein VC1974
0054086 5062 2010-05-31 d2i3da1 Atu1826-like
0053925 3936 2010-05-31 d2fuka1 Atu1826-like
0053804 1055 2010-05-31 d2d81a1 PHB depolymerase-like
0054008 858 2010-05-31 d2gzsa1 IroE-like
0053845 2117 2010-05-31 d2dsta1 TTHA1544-like
0053729 2393 2010-05-31 d2b61a1 O-acetyltransferase
0054709 3246 2010-05-31 d2vata1 O-acetyltransferase
0054522 2943 2010-05-31 d2pl5a1 O-acetyltransferase
0054207 5566 2010-05-31 d2jbwa1 2,6-dihydropseudooxynicotine hydrolase-like