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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this AP term (Not in SDAP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Tubulin nucleotide-binding domain-like	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
MurD-like peptide ligases, peptide-binding domain	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
EPT/RTPC-like	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
HRDC-like	0	DIRECT
Ribosomal protein L13	0	DIRECT
Mss4-like	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Arp2/3 complex subunits	0	DIRECT
Sigma2 domain of RNA polymerase sigma factors	0	DIRECT
Flavoproteins	0	DIRECT
Ribosomal protein S2	0	DIRECT
Trm112p-like	0	DIRECT
eIF4e-like	0	DIRECT
SAP domain	0	DIRECT
LanC-like	0	DIRECT
alpha/beta knot	0	DIRECT
Class II aaRS and biotin synthetases	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Macro domain-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
ACT-like	0	DIRECT
Nitrite and sulphite reductase 4Fe-4S domain-like	0	DIRECT
Ribosomal protein S3 C-terminal domain	0	DIRECT
Ribosomal protein L19 (L19e)	0	DIRECT
ssDNA-binding transcriptional regulator domain	0	DIRECT
HIT-like	0	DIRECT
N-terminal, heterodimerisation domain of RBP7 (RpoE)	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Tetrahydrobiopterin biosynthesis enzymes-like	0	DIRECT
Single hybrid motif	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
TGS-like	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
Mediator hinge subcomplex-like	0	DIRECT
N-terminal domain of the delta subunit of the F1F0-ATP synthase	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Chromo domain-like	0	DIRECT
Ribosomal protein L6	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
NAP-like	0	DIRECT
Ribosomal protein L29 (L29p)	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
Hypothetical protein TM0160	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
SIS domain	0	DIRECT
Electron transport accessory proteins	0	DIRECT
Ribosomal protein L4	0	DIRECT
L-aspartase-like	0	DIRECT
eEF-1beta-like	0	DIRECT
Tautomerase/MIF	0	DIRECT
RNase III domain-like	0	DIRECT
Lipoxigenase	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
LexA/Signal peptidase	0	DIRECT
FAD-linked oxidoreductase	0	DIRECT
Rps17e-like	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Tim10-like	0	DIRECT
RL5-like	0	DIRECT
UROD/MetE-like	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Mog1p/PsbP-like	0	DIRECT
Nucleoside hydrolase	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
BAG domain	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
Peptidyl-tRNA hydrolase-like	0	DIRECT
Sigma3 and sigma4 domains of RNA polymerase sigma factors	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
XPC-binding domain	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
PriA/YqbF domain	0	DIRECT
L28p-like	0	DIRECT
OMPA-like	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	0	DIRECT
Pentapeptide repeat-like	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Insert subdomain of RNA polymerase alpha subunit	0	DIRECT
DNA topoisomerase IV, alpha subunit	0	DIRECT
RplX-like	0	DIRECT
ATP synthase (F1-ATPase), gamma subunit	0	DIRECT
Enolase N-terminal domain-like	0	DIRECT
Ribosomal protein S6	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Expressed protein At2g23090/F21P24.15	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
Elongation factor TFIIS domain 2	0	DIRECT
Peptidyl-tRNA hydrolase II	0	DIRECT
GINS helical bundle-like	0	DIRECT
Folate-binding domain	0	DIRECT
Hypothetical protein YjiA, C-terminal domain	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
FMN-binding split barrel	0	DIRECT
Signal peptide-binding domain	0	DIRECT
Type II DNA topoisomerase	0	DIRECT
BAR/IMD domain-like	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Probable bacterial effector-binding domain	0	DIRECT
Gamma-glutamyl cyclotransferase-like	0	DIRECT
GroEL apical domain-like	0	DIRECT
Clc chloride channel	0	DIRECT
Smc hinge domain	0	DIRECT
FAH	0	DIRECT
YrdC/RibB	0	DIRECT
FKBP-like	0	DIRECT
Poly A polymerase C-terminal region-like	0	DIRECT
LysM domain	0	DIRECT
PUG domain-like	0	DIRECT
LigT-like	0	DIRECT
R3H domain	0	DIRECT
NHL repeat	0	DIRECT
S13-like H2TH domain	0	DIRECT
Tropomyosin	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
post-AAA+ oligomerization domain-like	0	DIRECT
Initiation factor IF2/eIF5b, domain 3	0	DIRECT
ITPase-like	0	DIRECT
Chelatase	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
Ribosomal protein S10	0	DIRECT
Coiled-coil domain of nucleotide exchange factor GrpE	0	DIRECT
YVTN repeat-like/Quinoprotein amine dehydrogenase	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Carbamate kinase-like	0	DIRECT
Translation initiation factor IF3, N-terminal domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Serine metabolism enzymes domain	0	DIRECT
Nicotinate/Quinolinate PRTase N-terminal domain-like	0	DIRECT
GlnB-like	0	DIRECT
Actin-crosslinking proteins	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Translation initiation factor IF3, C-terminal domain	0	DIRECT
Ribosomal protein L16p/L10e	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
RibA-like	0	DIRECT
Endosomal sorting complex assembly domain	0	DIRECT
Ribosomal protein L39e	0	DIRECT
AF1104-like	0	DIRECT
Prokaryotic ribosomal protein L17	0	DIRECT
Thymidylate synthase/dCMP hydroxymethylase	0	DIRECT
Ribosomal protein L31e	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
L9 N-domain-like	0	DIRECT
DNA breaking-rejoining enzymes	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
Enolase C-terminal domain-like	0	DIRECT
Oxygen-evolving enhancer protein 3,	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
ALDH-like	0	DIRECT
DNA clamp	0	DIRECT
ADC-like	0	DIRECT
Ribosomal protein L1	0	DIRECT
Alpha subunit of glutamate synthase, C-terminal domain	0	DIRECT
Radical SAM enzymes	0	DIRECT
Allene oxide cyclase-like	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
SH2 domain	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
BSD domain-like	0	DIRECT
Ribosomal protein L22	0	DIRECT
Ribosomal protein L14	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Phosphofructokinase	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Saposin	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Protein prenylyltransferase	0	DIRECT
Phosphoglycerate kinase	0	DIRECT
RuBisCO, small subunit	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Chlorophyll a-b binding protein	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Double Clp-N motif	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
PreATP-grasp domain	0	DIRECT
Staphylococcal nuclease	0	DIRECT
SH3-domain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
RecA protein, C-terminal domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
PLP-binding barrel	0	DIRECT
HesB-like domain	0	DIRECT
Chalcone isomerase	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Release factor	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Cytochrome c	0	DIRECT
Amine oxidase catalytic domain	0	DIRECT
beta-N-acetylhexosaminidase-like domain	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
Cysteine alpha-hairpin motif	0	DIRECT
eIF1-like	0	DIRECT
BolA-like	0	DIRECT
CYTH-like phosphatases	0	DIRECT
JAB1/MPN domain	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
Prefoldin	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Cytochrome c oxidase subunit h	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
DEK C-terminal domain	0	DIRECT
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Peptidase/esterase 'gauge' domain	0	DIRECT
Dimeric alpha+beta barrel	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
MurD-like peptide ligases, catalytic domain	0	DIRECT
Casein kinase II beta subunit	0	DIRECT
Formyltransferase	0	DIRECT
PX domain	0	DIRECT
Amine oxidase N-terminal region	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
SMR domain-like	0	DIRECT
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	DIRECT
Globin-like	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
LeuD/IlvD-like	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
AMPKBI-like	0	DIRECT
TATA-box binding protein-like	0	DIRECT
Pseudouridine synthase	0	DIRECT
Restriction endonuclease-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
ADP-ribosylation	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), lid domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Rubredoxin-like	0	DIRECT
Oxidoreductase molybdopterin-binding domain	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
FF domain	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Heme oxygenase-like	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
AlbA-like	0	DIRECT
Crambin-like	0	DIRECT
tRNA-binding arm	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
Dihydrofolate reductase-like	0	DIRECT
VC0467-like	0	DIRECT
beta-carbonic anhydrase, cab	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
MoaD/ThiS	0	DIRECT
Peptide methionine sulfoxide reductase	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
SAM/Pointed domain	0	DIRECT
RraA-like	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	0	DIRECT
Ligand-binding domain in the NO signalling and Golgi transport	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Chorismate mutase II	0	DIRECT
WW domain	0	DIRECT
Mitochondrial glycoprotein MAM33-like	0	DIRECT
ISP domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Prokaryotic type I DNA topoisomerase	0	DIRECT
Nucleotidylyl transferase	0	DIRECT
Preprotein translocase SecE subunit	0	DIRECT
Mitochondrial carrier	0	DIRECT
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	0	DIRECT
Prokaryotic type KH domain (KH-domain type II)	0	DIRECT
Lipocalins	0	DIRECT
Head domain of nucleotide exchange factor GrpE	0	DIRECT
YhbY-like	0	DIRECT
RNA-binding domain, RBD	0.00000008848	DIRECT
Chaperone J-domain	0.000003957	DIRECT
Thioredoxin-like	0.000006337	DIRECT
WD40 repeat-like	0.000009373	DIRECT
Nucleic acid-binding proteins	0.00005618	DIRECT
ARM repeat	0.00006295	DIRECT
Ribosomal protein S5 domain 2-like	0.0002813	DIRECT
P-loop containing nucleoside triphosphate hydrolases	0.1729	INHERITED FROM: guard cell

Family domains annotated to this AP term (Not in SDAP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
DNA polymerase processivity factor	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Alpha-adaptin ear subdomain-like	0	DIRECT
Insert subdomain of RNA polymerase alpha subunit	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
RuBisCo LSMT catalytic domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Folylpolyglutamate synthetase	0	DIRECT
HD domain	0	DIRECT
RNA polymerase II subunit RBP4 (RpoF)	0	DIRECT
Thymidylate synthase/dCMP hydroxymethylase	0	DIRECT
L23p	0	DIRECT
XPC-binding domain	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
Nucleotide and nucleoside kinases	0	DIRECT
Casein kinase II beta subunit	0	DIRECT
Translation initiation factor IF3, C-terminal domain	0	DIRECT
Rps19E-like	0	DIRECT
GlmU C-terminal domain-like	0	DIRECT
Ribosomal protein L19	0	DIRECT
SOUL heme-binding protein	0	DIRECT
Pentapeptide repeats	0	DIRECT
PA domain	0	DIRECT
Chalcone isomerase	0	DIRECT
Tetrahydrofolate dehydrogenase/cyclohydrolase	0	DIRECT
PDI-like	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
28-residue LRR	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	0	DIRECT
Type II DNA topoisomerase	0	DIRECT
RibA-like	0	DIRECT
Cytochrome c oxidase subunit h	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
HAL/PAL-like	0	DIRECT
Macro domain	0	DIRECT
Flavin-binding PAS domain	0	DIRECT
Dihydrodipicolinate reductase-like	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
Plant lipoxigenases	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
Subtilase propeptides/inhibitors	0	DIRECT
Glucose 6-phosphate dehydrogenase-like	0	DIRECT
Plant stress-induced protein	0	DIRECT
FKBP immunophilin/proline isomerase	0	DIRECT
Peptide methionine sulfoxide reductase	0	DIRECT
HMGL-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
N-terminal, heterodimerisation domain of RBP7 (RpoE)	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
Enolase N-terminal domain-like	0	DIRECT
eIF5a N-terminal domain-like	0	DIRECT
RNA polymerase alpha subunit dimerisation domain	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Initiation factor IF2/eIF5b, domain 3	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
WrbA-like	0	DIRECT
Hypothetical protein YjiA, C-terminal domain	0	DIRECT
Hypothetical protein HI1317	0	DIRECT
PsbP-like	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	0	DIRECT
HEAT repeat	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
VC0467-like	0	DIRECT
Tail specific protease, catalytic domain	0	DIRECT
Allosteric chorismate mutase	0	DIRECT
RNase Z-like	0	DIRECT
AF1104-like	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
Leucine aminopeptidase (Aminopeptidase A), N-terminal domain	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
FAH	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Zf-UBP	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Mitochondrial glycoprotein MAM33-like	0	DIRECT
HesB-like domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Phosphoglycerate kinase	0	DIRECT
Ribosomal protein L19 (L19e)	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase dimerisation domain	0	DIRECT
Chromo barrel domain	0	DIRECT
SH3-domain	0	DIRECT
Swaposin	0	DIRECT
Carbon-carbon bond hydrolase	0	DIRECT
Phytochrome-specific domain	0	DIRECT
GABARAP-like	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Prefoldin	0	DIRECT
Hermes transposase-like	0	DIRECT
Amine oxidase N-terminal region	0	DIRECT
Plant transcriptional regulator PBF-2	0	DIRECT
ATP synthase (F1-ATPase), gamma subunit	0	DIRECT
Transcriptional coactivator PC4 C-terminal domain	0	DIRECT
RNB domain-like	0	DIRECT
Internalin LRR domain	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Tudor domain	0	DIRECT
PdxS-like	0	DIRECT
DNA gyrase/MutL, second domain	0	DIRECT
Smr domain	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
IF2B-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
NifU C-terminal domain-like	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
DNA repair glycosylase, 2 C-terminal domains	0	DIRECT
UBX domain	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Ring hydroxylating alpha subunit ISP domain	0	DIRECT
L-aspartase/fumarase	0	DIRECT
Threonyl-tRNA synthetase (ThrRS), second 'additional' domain	0	DIRECT
Homoserine dehydrogenase-like	0	DIRECT
NHL repeat	0	DIRECT
BSD domain	0	DIRECT
SH2 domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Ribosomal protein L29 (L29p)	0	DIRECT
Penta-EF-hand proteins	0	DIRECT
Ribosomal protein L31e	0	DIRECT
SufE-like	0	DIRECT
Sigma4 domain	0	DIRECT
Ribosomal protein S27a	0	DIRECT
Smc hinge domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
Ribosomal protein L4	0	DIRECT
Ribosomal proteins L24p and L21e	0	DIRECT
Cold shock DNA-binding domain-like	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
NadC N-terminal domain-like	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Serine acetyltransferase	0	DIRECT
SWIRM domain	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
Formate/glycerate dehydrogenases, substrate-binding domain	0	DIRECT
PUG domain	0	DIRECT
SpoU-like RNA 2'-O ribose methyltransferase	0	DIRECT
Calnexin/calreticulin	0	DIRECT
C-terminal domain of ribosomal protein L2	0	DIRECT
Ferritin	0	DIRECT
Glycerol-3-phosphate dehydrogenase	0	DIRECT
Nucleoside hydrolase	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
Ribonuclease H	0	DIRECT
Met-10+ protein-like	0	DIRECT
NAD kinase-like	0	DIRECT
Oxygen-evolving enhancer protein 3,	0	DIRECT
PNP-oxidase like	0	DIRECT
PyrH-like	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Ribosomal protein L10e	0	DIRECT
Heme-dependent catalases	0	DIRECT
Spermidine synthase	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
ATP sulfurylase catalytic domain	0	DIRECT
Class-II DAHP synthetase	0	DIRECT
Ribosomal protein L37e	0	DIRECT
PaaI/YdiI-like	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Protein prenylyltransferase	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
Phosphofructokinase	0	DIRECT
Ribosomal protein S13	0	DIRECT
Shikimate kinase (AroK)	0	DIRECT
Hypothetical protein At2g34160	0	DIRECT
DNase I-like	0	DIRECT
HCP-like	0	DIRECT
Adenosine-5'phosphosulfate kinase (APS kinase)	0	DIRECT
GAT domain	0	DIRECT
Amylase, catalytic domain	0	DIRECT
beta-N-acetylhexosaminidase catalytic domain	0	DIRECT
BAR domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Signal peptide-binding domain	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Clathrin adaptor appendage, alpha and beta chain-specific domain	0	DIRECT
Ribosomal protein S27e	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
PUA domain	0	DIRECT
Neurolysin-like	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Enolase	0	DIRECT
Gamma-glutamyl cyclotransferase-like	0	DIRECT
Cytochrome b5	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
eEF-1beta-like	0	DIRECT
RWD domain	0	DIRECT
Ribosomal protein L5	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
2Fe-2S ferredoxin-related	0	DIRECT
Hypothetical protein TM0160	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
PhzC/PhzF-like	0	DIRECT
HIT (HINT, histidine triad) family of protein kinase-interacting proteins	0	DIRECT
Ribosomal protein L35ae	0	DIRECT
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0	DIRECT
Tim10/DDP	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Ribosomal protein S15	0	DIRECT
PX domain	0	DIRECT
Plus3	0	DIRECT
Thiolase-related	0	DIRECT
LEA14-like	0	DIRECT
Peptidyl-tRNA hydrolase II	0	DIRECT
Sigma2 domain of RNA polymerase sigma factors	0	DIRECT
Ribosomal protein L39e	0	DIRECT
Cytidylyltransferase	0	DIRECT
Prokaryotic ribosomal protein L17	0	DIRECT
Ribosomal protein L14	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Pseudouridine synthase RsuA/RluD	0	DIRECT
PAPS reductase-like	0	DIRECT
FF domain	0	DIRECT
5' nucleotidase-like	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
BolA-like	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Glyoxalase II (hydroxyacylglutathione hydrolase)	0	DIRECT
Pseudouridine synthase II TruB	0	DIRECT
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
Chromo domain	0	DIRECT
Prokaryotic type KH domain (KH-domain type II)	0	DIRECT
Cystatins	0	DIRECT
RelA/SpoT domain	0	DIRECT
LON domain-like	0	DIRECT
RIO1-like kinases	0	DIRECT
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	DIRECT
Ran-binding domain	0	DIRECT
WW domain	0	DIRECT
Hypoxia-inducible factor HIF ihhibitor (FIH1)	0	DIRECT
Ribosomal protein S2	0	DIRECT
Cell cycle arrest protein BUB3	0	DIRECT
VHS domain	0	DIRECT
Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain	0	DIRECT
ECR1 N-terminal domain-like	0	DIRECT
GAPDH-like	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
SAP domain	0	DIRECT
Prokaryotic type I DNA topoisomerase	0	DIRECT
Phosphoribosylpyrophosphate synthetase-like	0	DIRECT
(Glycosyl)asparaginase	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
beta-Phosphoglucomutase-like	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
Bacterial PLC	0	DIRECT
Alpha subunit of glutamate synthase, C-terminal domain	0	DIRECT
Aminoacid dehydrogenases	0	DIRECT
Rubredoxin	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), catalytic domain	0	DIRECT
Ribosomal protein L3	0	DIRECT
Epoxide hydrolase	0	DIRECT
VPS23 C-terminal domain	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
RraA-like	0	DIRECT
Gtf glycosyltransferase	0	DIRECT
Ribosomal protein L22	0	DIRECT
3-Methyladenine DNA glycosylase I (Tag)	0	DIRECT
Alanine racemase-like, N-terminal domain	0	DIRECT
IPP isomerase-like	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	0	DIRECT
BphP N-terminal domain-like	0	DIRECT
DNA topoisomerase IV, alpha subunit	0	DIRECT
Hypothetical protein TM1112	0	DIRECT
Pirin-like	0	DIRECT
G domain-linked domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Head domain of nucleotide exchange factor GrpE	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
eIF1-like	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
LysM domain	0	DIRECT
NadC C-terminal domain-like	0	DIRECT
Ribosomal protein S6	0	DIRECT
NagD-like	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
MIF-related	0	DIRECT
Arginine methyltransferase	0	DIRECT
Tryptophan biosynthesis enzymes	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
D-ribulose-5-phosphate 3-epimerase	0	DIRECT
MYND zinc finger	0	DIRECT
RecA protein, C-terminal domain	0	DIRECT
CAT-like	0	DIRECT
RuBisCO, small subunit	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
Chlorophyll a-b binding protein	0	DIRECT
BAG domain	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Eukaryotic type heme oxygenase	0	DIRECT
Amine oxidase catalytic domain	0	DIRECT
HspBP1 domain	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
AMPKBI-like	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
Molybdenum-containing oxidoreductases-like dimerisation domain	0	DIRECT
Diacylglycerol kinase-like	0	DIRECT
Proteasome subunits	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
B56-like	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
DJ-1/PfpI	0	DIRECT
Ribosomal protein S3 C-terminal domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
MPP-like	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Protein prenyltransferases	0	DIRECT
Coiled-coil domain of nucleotide exchange factor GrpE	0	DIRECT
N-acetyl-l-glutamate kinase	0	DIRECT
GroES	0	DIRECT
Class I aldolase	0	DIRECT
Formyltransferase	0	DIRECT
monodomain cytochrome c	0	DIRECT
Leucine aminopeptidase, C-terminal domain	0	DIRECT
YicI N-terminal domain-like	0	DIRECT
NAP-like	0	DIRECT
R3H domain	0	DIRECT
Allene oxide cyclase-like	0	DIRECT
Dihydrofolate reductases	0	DIRECT
Succinyl-CoA synthetase, beta-chain, N-terminal domain	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Oxidoreductase molybdopterin-binding domain	0	DIRECT
FucT-like	0	DIRECT
GroEL-like chaperone, apical domain	0	DIRECT
ATP sulfurylase N-terminal domain	0	DIRECT
EXOSC10 HRDC domain-like	0	DIRECT
Peptidyl-tRNA hydrolase-like	0	DIRECT
Elongation factor TFIIS domain 2	0	DIRECT
Preprotein translocase SecE subunit	0	DIRECT
Ribosomal S5 protein, N-terminal domain	0	DIRECT
GroEL-like chaperone, intermediate domain	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Myf domain	0	DIRECT
Aspartokinase allosteric domain-like	0	DIRECT
AlkB-like	0	DIRECT
Reductases	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Translation initiation factor IF3, N-terminal domain	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
Clp protease, ClpP subunit	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Starch-binding domain	0	DIRECT
HAT/Suf repeat	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Cytochrome c oxidase Subunit F	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
Glyoxalase I (lactoylglutathione lyase)	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
Nitrite and sulphite reductase 4Fe-4S domain-like	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Prolyl oligopeptidase, N-terminal domain	0	DIRECT
Cobalamin-independent methionine synthase	0	DIRECT
Crambin-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), lid domain	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
MutT-like	0	DIRECT
LplA-like	0	DIRECT
EDF1-like	0	DIRECT
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	0	DIRECT
Anticodon-binding domain	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Ribosomal protein L13	0	DIRECT
Poly A polymerase C-terminal region-like	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
Rieske iron-sulfur protein (ISP)	0	DIRECT
Release factor	0	DIRECT
T7 RNA polymerase	0	DIRECT
Translational machinery components	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
UEV domain	0	DIRECT
Prolyl oligopeptidase, C-terminal domain	0	DIRECT
SerA intervening domain-like	0	DIRECT
SelR domain	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Linker histone H1/H5	0	DIRECT
Choline kinase	0	DIRECT
E2F dimerization segment	0	DIRECT
PCI domain (PINT motif)	0	DIRECT
Molybdenum cofactor biosynthesis protein MoeB	0	DIRECT
Arp2/3 complex subunits	0	DIRECT
RNase III catalytic domain-like	0	DIRECT
Ribosomal protein L6	0	DIRECT
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase LpxC	0	DIRECT
Staphylococcal nuclease	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Type 1 signal peptidase	0	DIRECT
gamma-carbonic anhydrase-like	0	DIRECT
Eukaryotic DNA topoisomerase I, catalytic core	0	DIRECT
ZZ domain	0	DIRECT
CoA-binding domain	0	DIRECT
Methyl-CpG-binding domain, MBD	0	DIRECT
glucose-1-phosphate thymidylyltransferase	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
LeuD-like	0	DIRECT
Lipoxigenase N-terminal domain	0	DIRECT
beta-carbonic anhydrase, cab	0	DIRECT
Clc chloride channel	0	DIRECT
RNA-polymerase beta	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Acyl-ACP thioesterase-like	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
ALDH-like	0	DIRECT
rRNA adenine dimethylase-like	0	DIRECT
Ribosomal L27 protein	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
RplX-like	0	DIRECT
Cytochrome p450 reductase N-terminal domain-like	0	DIRECT
Gelsolin-like	0	DIRECT
Rps17e-like	0	DIRECT
Mitochondrial carrier	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Poly A polymerase head domain-like	0	DIRECT
Sedlin (SEDL)	0	DIRECT
GroEL chaperone, ATPase domain	0	DIRECT
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB	0	DIRECT
PsbO-like	0	DIRECT
UBA domain	0	DIRECT
PWWP domain	0	DIRECT
TRM1-like	0	DIRECT
Tropomyosin	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
DEK C-terminal domain	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Double Clp-N motif	0	DIRECT
YhbY-like	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
Canonical RBD	0.000001467	DIRECT
Chaperone J-domain	0.000003106	DIRECT
WD40-repeat	0.00001974	DIRECT
G proteins	0.0000854	DIRECT