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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this AP term (Not in SDAP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
PUG domain-like	0	DIRECT
RibA-like	0	DIRECT
N-terminal, heterodimerisation domain of RBP7 (RpoE)	0	DIRECT
YrdC/RibB	0	DIRECT
Poly A polymerase C-terminal region-like	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Ribosomal protein S2	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
SMR domain-like	0	DIRECT
FF domain	0	DIRECT
RplX-like	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Expressed protein At2g23090/F21P24.15	0	DIRECT
Nucleotidylyl transferase	0	DIRECT
Cysteine alpha-hairpin motif	0	DIRECT
L9 N-domain-like	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Signal peptide-binding domain	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Ribosomal protein L22	0	DIRECT
Sigma2 domain of RNA polymerase sigma factors	0	DIRECT
beta-N-acetylhexosaminidase-like domain	0	DIRECT
eIF4e-like	0	DIRECT
Thymidylate synthase/dCMP hydroxymethylase	0	DIRECT
Electron transport accessory proteins	0	DIRECT
Phosphofructokinase	0	DIRECT
ADP-ribosylation	0	DIRECT
RraA-like	0	DIRECT
Chalcone isomerase	0	DIRECT
CYTH-like phosphatases	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Serine metabolism enzymes domain	0	DIRECT
Preprotein translocase SecE subunit	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
PriA/YqbF domain	0	DIRECT
Elongation factor TFIIS domain 2	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Gamma-glutamyl cyclotransferase-like	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
SIS domain	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
Prokaryotic type KH domain (KH-domain type II)	0	DIRECT
Folate-binding domain	0	DIRECT
RNase III domain-like	0	DIRECT
Chelatase	0	DIRECT
Tetrahydrobiopterin biosynthesis enzymes-like	0	DIRECT
Nitrite and sulphite reductase 4Fe-4S domain-like	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Ribosomal protein L4	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
ISP domain	0	DIRECT
Arp2/3 complex subunits	0	DIRECT
Ribosomal protein L19 (L19e)	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
L-aspartase-like	0	DIRECT
Macro domain-like	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Rubredoxin-like	0	DIRECT
Formyltransferase	0	DIRECT
Lipoxigenase	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
DNA topoisomerase IV, alpha subunit	0	DIRECT
OMPA-like	0	DIRECT
Sigma3 and sigma4 domains of RNA polymerase sigma factors	0	DIRECT
Peptidase/esterase 'gauge' domain	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
Single hybrid motif	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
Mitochondrial glycoprotein MAM33-like	0	DIRECT
Enolase N-terminal domain-like	0	DIRECT
HIT-like	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
YhbY-like	0	DIRECT
N-terminal domain of the delta subunit of the F1F0-ATP synthase	0	DIRECT
Tropomyosin	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Ribosomal protein S3 C-terminal domain	0	DIRECT
RuBisCO, small subunit	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
HRDC-like	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
Amine oxidase catalytic domain	0	DIRECT
Ribosomal protein L14	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Smc hinge domain	0	DIRECT
Radical SAM enzymes	0	DIRECT
EPT/RTPC-like	0	DIRECT
Casein kinase II beta subunit	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), lid domain	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Restriction endonuclease-like	0	DIRECT
beta-carbonic anhydrase, cab	0	DIRECT
Allene oxide cyclase-like	0	DIRECT
LigT-like	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Probable bacterial effector-binding domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
PLP-binding barrel	0	DIRECT
Mog1p/PsbP-like	0	DIRECT
Tautomerase/MIF	0	DIRECT
Double Clp-N motif	0	DIRECT
Oxidoreductase molybdopterin-binding domain	0	DIRECT
post-AAA+ oligomerization domain-like	0	DIRECT
Pseudouridine synthase	0	DIRECT
ITPase-like	0	DIRECT
Tim10-like	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
MurD-like peptide ligases, catalytic domain	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
Cytochrome c oxidase subunit h	0	DIRECT
Phosphoglycerate kinase	0	DIRECT
ATP synthase (F1-ATPase), gamma subunit	0	DIRECT
MurD-like peptide ligases, peptide-binding domain	0	DIRECT
Chlorophyll a-b binding protein	0	DIRECT
BolA-like	0	DIRECT
VC0467-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
LeuD/IlvD-like	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Protein prenylyltransferase	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Translation initiation factor IF3, C-terminal domain	0	DIRECT
LysM domain	0	DIRECT
Peptide methionine sulfoxide reductase	0	DIRECT
Trm112p-like	0	DIRECT
LanC-like	0	DIRECT
Amine oxidase N-terminal region	0	DIRECT
WW domain	0	DIRECT
Enolase C-terminal domain-like	0	DIRECT
AMPKBI-like	0	DIRECT
Head domain of nucleotide exchange factor GrpE	0	DIRECT
Ribosomal protein L29 (L29p)	0	DIRECT
AF1104-like	0	DIRECT
Nicotinate/Quinolinate PRTase N-terminal domain-like	0	DIRECT
Oxygen-evolving enhancer protein 3,	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
BAG domain	0	DIRECT
ssDNA-binding transcriptional regulator domain	0	DIRECT
FMN-binding split barrel	0	DIRECT
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	DIRECT
BAR/IMD domain-like	0	DIRECT
Ribosomal protein S6	0	DIRECT
UROD/MetE-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Actin-crosslinking proteins	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
DEK C-terminal domain	0	DIRECT
TATA-box binding protein-like	0	DIRECT
Ribosomal protein L39e	0	DIRECT
RL5-like	0	DIRECT
Ligand-binding domain in the NO signalling and Golgi transport	0	DIRECT
Staphylococcal nuclease	0	DIRECT
XPC-binding domain	0	DIRECT
Alpha subunit of glutamate synthase, C-terminal domain	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
tRNA-binding arm	0	DIRECT
FKBP-like	0	DIRECT
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0	DIRECT
Pentapeptide repeat-like	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
GroEL apical domain-like	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
Heme oxygenase-like	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Cytochrome c	0	DIRECT
Release factor	0	DIRECT
Flavoproteins	0	DIRECT
Mss4-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
MoaD/ThiS	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
Nucleoside hydrolase	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
alpha/beta knot	0	DIRECT
Chromo domain-like	0	DIRECT
eIF1-like	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
YVTN repeat-like/Quinoprotein amine dehydrogenase	0	DIRECT
Hypothetical protein TM0160	0	DIRECT
NAP-like	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Ribosomal protein L31e	0	DIRECT
R3H domain	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Coiled-coil domain of nucleotide exchange factor GrpE	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
FAD-linked oxidoreductase	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Crambin-like	0	DIRECT
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	0	DIRECT
SH3-domain	0	DIRECT
NHL repeat	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
Ribosomal protein L13	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Peptidyl-tRNA hydrolase-like	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
Type II DNA topoisomerase	0	DIRECT
Rps17e-like	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
GINS helical bundle-like	0	DIRECT
Peptidyl-tRNA hydrolase II	0	DIRECT
Globin-like	0	DIRECT
Lipocalins	0	DIRECT
SAP domain	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Insert subdomain of RNA polymerase alpha subunit	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Carbamate kinase-like	0	DIRECT
L28p-like	0	DIRECT
Prokaryotic ribosomal protein L17	0	DIRECT
Prefoldin	0	DIRECT
RecA protein, C-terminal domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
ALDH-like	0	DIRECT
Saposin	0	DIRECT
Class II aaRS and biotin synthetases	0	DIRECT
eEF-1beta-like	0	DIRECT
FAH	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Ribosomal protein L6	0	DIRECT
LexA/Signal peptidase	0	DIRECT
Mitochondrial carrier	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Mediator hinge subcomplex-like	0	DIRECT
ADC-like	0	DIRECT
Translation initiation factor IF3, N-terminal domain	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Ribosomal protein L1	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
Dimeric alpha+beta barrel	0	DIRECT
GlnB-like	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	0	DIRECT
Prokaryotic type I DNA topoisomerase	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
JAB1/MPN domain	0	DIRECT
Initiation factor IF2/eIF5b, domain 3	0	DIRECT
Hypothetical protein YjiA, C-terminal domain	0	DIRECT
AlbA-like	0	DIRECT
BSD domain-like	0	DIRECT
ACT-like	0	DIRECT
HesB-like domain	0	DIRECT
PX domain	0	DIRECT
S13-like H2TH domain	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
DNA breaking-rejoining enzymes	0	DIRECT
SAM/Pointed domain	0	DIRECT
DNA clamp	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
Chorismate mutase II	0	DIRECT
Dihydrofolate reductase-like	0	DIRECT
PreATP-grasp domain	0	DIRECT
Endosomal sorting complex assembly domain	0	DIRECT
Clc chloride channel	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Ribosomal protein L16p/L10e	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
TGS-like	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
SH2 domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
RNA-binding domain, RBD	0.00000008848	DIRECT
Chaperone J-domain	0.000003957	DIRECT
Thioredoxin-like	0.000006337	DIRECT
WD40 repeat-like	0.000009373	DIRECT
Nucleic acid-binding proteins	0.00005618	DIRECT
ARM repeat	0.00006295	DIRECT
Ribosomal protein S5 domain 2-like	0.0002813	DIRECT
P-loop containing nucleoside triphosphate hydrolases	0.1729	INHERITED FROM: guard cell

Family domains annotated to this AP term (Not in SDAP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
SH3-domain	0	DIRECT
Peptidyl-tRNA hydrolase II	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
RelA/SpoT domain	0	DIRECT
Tail specific protease, catalytic domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Smr domain	0	DIRECT
PUG domain	0	DIRECT
PAPS reductase-like	0	DIRECT
Glucose 6-phosphate dehydrogenase-like	0	DIRECT
Phytochrome-specific domain	0	DIRECT
Ran-binding domain	0	DIRECT
ZZ domain	0	DIRECT
SpoU-like RNA 2'-O ribose methyltransferase	0	DIRECT
Proteasome subunits	0	DIRECT
Cytidylyltransferase	0	DIRECT
DEK C-terminal domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Subtilase propeptides/inhibitors	0	DIRECT
DNA repair glycosylase, 2 C-terminal domains	0	DIRECT
AMPKBI-like	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
Flavin-binding PAS domain	0	DIRECT
Serine acetyltransferase	0	DIRECT
RIO1-like kinases	0	DIRECT
Acyl-ACP thioesterase-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Homoserine dehydrogenase-like	0	DIRECT
Plus3	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Allene oxide cyclase-like	0	DIRECT
DNA topoisomerase IV, alpha subunit	0	DIRECT
HAT/Suf repeat	0	DIRECT
Coiled-coil domain of nucleotide exchange factor GrpE	0	DIRECT
Ribosomal protein L35ae	0	DIRECT
Tim10/DDP	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0	DIRECT
Cytochrome p450 reductase N-terminal domain-like	0	DIRECT
RNase III catalytic domain-like	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
ALDH-like	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
28-residue LRR	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
ATP sulfurylase catalytic domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	0	DIRECT
Formate/glycerate dehydrogenases, substrate-binding domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Met-10+ protein-like	0	DIRECT
Gelsolin-like	0	DIRECT
Eukaryotic DNA topoisomerase I, catalytic core	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
Ribosomal protein L39e	0	DIRECT
SOUL heme-binding protein	0	DIRECT
TRM1-like	0	DIRECT
Ribosomal protein L4	0	DIRECT
UEV domain	0	DIRECT
beta-N-acetylhexosaminidase catalytic domain	0	DIRECT
Protein prenyltransferases	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
L-aspartase/fumarase	0	DIRECT
Arginine methyltransferase	0	DIRECT
(Glycosyl)asparaginase	0	DIRECT
Ribosomal protein L1	0	DIRECT
Ribosomal protein S2	0	DIRECT
Lipoxigenase N-terminal domain	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
GroES	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
eIF5a N-terminal domain-like	0	DIRECT
Peptide methionine sulfoxide reductase	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Pentapeptide repeats	0	DIRECT
RWD domain	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
D-ribulose-5-phosphate 3-epimerase	0	DIRECT
Zf-UBP	0	DIRECT
Methyl-CpG-binding domain, MBD	0	DIRECT
PNP-oxidase like	0	DIRECT
Ran binding protein zinc finger-like	0	DIRECT
LEA14-like	0	DIRECT
Clp protease, ClpP subunit	0	DIRECT
Insert subdomain of RNA polymerase alpha subunit	0	DIRECT
Enolase	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
PDI-like	0	DIRECT
RuBisCo LSMT catalytic domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain	0	DIRECT
Linker histone H1/H5	0	DIRECT
BolA-like	0	DIRECT
Glyoxalase II (hydroxyacylglutathione hydrolase)	0	DIRECT
Bacterial PLC	0	DIRECT
Cell cycle arrest protein BUB3	0	DIRECT
Galectin (animal S-lectin)	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
GroEL chaperone, ATPase domain	0	DIRECT
Transcriptional coactivator PC4 C-terminal domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Oxygen-evolving enhancer protein 3,	0	DIRECT
Release factor	0	DIRECT
Heme-dependent catalases	0	DIRECT
Reductases	0	DIRECT
GroEL-like chaperone, intermediate domain	0	DIRECT
Chlorophyll a-b binding protein	0	DIRECT
Ribosomal protein L29 (L29p)	0	DIRECT
ATP sulfurylase N-terminal domain	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	0	DIRECT
Pirin-like	0	DIRECT
Dihydrodipicolinate reductase-like	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Swaposin	0	DIRECT
Phosphoribosylpyrophosphate synthetase-like	0	DIRECT
Thiolase-related	0	DIRECT
Internalin LRR domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Ribosomal protein L14	0	DIRECT
VC0467-like	0	DIRECT
Dihydrofolate reductases	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
FF domain	0	DIRECT
Ring hydroxylating alpha subunit ISP domain	0	DIRECT
Ribonuclease H	0	DIRECT
HAL/PAL-like	0	DIRECT
Threonyl-tRNA synthetase (ThrRS), second 'additional' domain	0	DIRECT
5' nucleotidase-like	0	DIRECT
LplA-like	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
eEF-1beta-like	0	DIRECT
Peptidyl-tRNA hydrolase-like	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Ribosomal protein L19 (L19e)	0	DIRECT
PCI domain (PINT motif)	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Plant transcriptional regulator PBF-2	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Glycerol-3-phosphate dehydrogenase	0	DIRECT
WW domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
BAG domain	0	DIRECT
Plant stress-induced protein	0	DIRECT
Mitochondrial glycoprotein MAM33-like	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Elongation factor TFIIS domain 2	0	DIRECT
Transcription factor IIA (TFIIA), beta-barrel domain	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
GABARAP-like	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
VHS domain	0	DIRECT
Gtf glycosyltransferase	0	DIRECT
SWIRM domain	0	DIRECT
G domain-linked domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
GroEL-like chaperone, apical domain	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
Casein kinase II beta subunit	0	DIRECT
Sigma2 domain of RNA polymerase sigma factors	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Chromo barrel domain	0	DIRECT
Nucleoside hydrolase	0	DIRECT
Double Clp-N motif	0	DIRECT
Ribosomal protein L3	0	DIRECT
YhbY-like	0	DIRECT
Alpha-adaptin ear subdomain-like	0	DIRECT
AlkB-like	0	DIRECT
SelR domain	0	DIRECT
Tryptophan biosynthesis enzymes	0	DIRECT
Ribosomal L27 protein	0	DIRECT
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0	DIRECT
Leucine aminopeptidase (Aminopeptidase A), N-terminal domain	0	DIRECT
Amine oxidase catalytic domain	0	DIRECT
RNB domain-like	0	DIRECT
Ribosomal protein L10e	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Hermes transposase-like	0	DIRECT
NAD kinase-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Alanine racemase-like, N-terminal domain	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
PUA domain	0	DIRECT
FucT-like	0	DIRECT
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
Rieske iron-sulfur protein (ISP)	0	DIRECT
Signal peptide-binding domain	0	DIRECT
PaaI/YdiI-like	0	DIRECT
Eukaryotic type heme oxygenase	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
DNase I-like	0	DIRECT
NadC N-terminal domain-like	0	DIRECT
Pseudouridine synthase II TruB	0	DIRECT
Choline kinase	0	DIRECT
Hect, E3 ligase catalytic domain	0	DIRECT
UBX domain	0	DIRECT
HIT (HINT, histidine triad) family of protein kinase-interacting proteins	0	DIRECT
RNA polymerase II subunit RBP4 (RpoF)	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), catalytic domain	0	DIRECT
Ribosomal protein S6	0	DIRECT
Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain	0	DIRECT
Molybdenum cofactor biosynthesis protein MoeB	0	DIRECT
ATP synthase (F1-ATPase), gamma subunit	0	DIRECT
SAP domain	0	DIRECT
HesB-like domain	0	DIRECT
LON domain-like	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Carbon-carbon bond hydrolase	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
RNA polymerase alpha subunit dimerisation domain	0	DIRECT
Type II DNA topoisomerase	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Gamma-glutamyl cyclotransferase-like	0	DIRECT
Aminoacid dehydrogenases	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Transcription factor IIA (TFIIA), alpha-helical domain	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB	0	DIRECT
Thymidylate synthase/dCMP hydroxymethylase	0	DIRECT
Oxidoreductase molybdopterin-binding domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
DNA gyrase/MutL, second domain	0	DIRECT
Rps17e-like	0	DIRECT
YicI N-terminal domain-like	0	DIRECT
Ribosomal protein L31e	0	DIRECT
MYND zinc finger	0	DIRECT
C-terminal domain of ribosomal protein L2	0	DIRECT
Adenosine-5'phosphosulfate kinase (APS kinase)	0	DIRECT
NadC C-terminal domain-like	0	DIRECT
GAPDH-like	0	DIRECT
2Fe-2S ferredoxin-related	0	DIRECT
Poly A polymerase C-terminal region-like	0	DIRECT
Cytochrome c oxidase Subunit F	0	DIRECT
Ribosomal protein L13	0	DIRECT
Amylase, catalytic domain	0	DIRECT
Glyoxalase I (lactoylglutathione lyase)	0	DIRECT
HCP-like	0	DIRECT
Chalcone isomerase	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
CAT-like	0	DIRECT
Plant lipoxigenases	0	DIRECT
B56-like	0	DIRECT
Tudor domain	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Translation initiation factor IF3, C-terminal domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
RplX-like	0	DIRECT
Calnexin/calreticulin	0	DIRECT
Tryptophan synthase beta subunit-like PLP-dependent enzymes	0	DIRECT
BSD domain	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
HEAT repeat	0	DIRECT
Hypothetical protein TM0160	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
Preprotein translocase SecE subunit	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
RNA-polymerase beta	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
MutT-like	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Arp2/3 complex subunits	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
SerA intervening domain-like	0	DIRECT
Rps19E-like	0	DIRECT
Prolyl oligopeptidase, N-terminal domain	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Cold shock DNA-binding domain-like	0	DIRECT
Crambin-like	0	DIRECT
Cytochrome c oxidase subunit h	0	DIRECT
LeuD-like	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
Shikimate kinase (AroK)	0	DIRECT
AF1104-like	0	DIRECT
PhzC/PhzF-like	0	DIRECT
Protein prenylyltransferase	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
NagD-like	0	DIRECT
Ribosomal protein S27e	0	DIRECT
Neurolysin-like	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Molybdenum-containing oxidoreductases-like dimerisation domain	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
FKBP immunophilin/proline isomerase	0	DIRECT
IF2B-like	0	DIRECT
HD domain	0	DIRECT
NifU C-terminal domain-like	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0	DIRECT
Class I aldolase	0	DIRECT
Phosphofructokinase	0	DIRECT
SH2 domain	0	DIRECT
PA domain	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
VPS23 C-terminal domain	0	DIRECT
Spermidine synthase	0	DIRECT
RNase Z-like	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
Rubredoxin	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
Ribosomal protein S27a	0	DIRECT
Translation initiation factor IF3, N-terminal domain	0	DIRECT
NAP-like	0	DIRECT
rRNA adenine dimethylase-like	0	DIRECT
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase LpxC	0	DIRECT
IPP isomerase-like	0	DIRECT
Amine oxidase N-terminal region	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
Ribosomal proteins L24p and L21e	0	DIRECT
beta-carbonic anhydrase, cab	0	DIRECT
Staphylococcal nuclease	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Smc hinge domain	0	DIRECT
Hypothetical protein At2g34160	0	DIRECT
PyrH-like	0	DIRECT
Prolyl oligopeptidase, C-terminal domain	0	DIRECT
Ribosomal S5 protein, N-terminal domain	0	DIRECT
Clathrin adaptor appendage, alpha and beta chain-specific domain	0	DIRECT
Starch-binding domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
Folylpolyglutamate synthetase	0	DIRECT
Ribosomal protein S13	0	DIRECT
Nitrite and sulphite reductase 4Fe-4S domain-like	0	DIRECT
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0	DIRECT
Anticodon-binding domain	0	DIRECT
EDF1-like	0	DIRECT
Cystatins	0	DIRECT
Initiation factor IF2/eIF5b, domain 3	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
Macro domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
UBA domain	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
BAR domain	0	DIRECT
Penta-EF-hand proteins	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
L23p	0	DIRECT
Prokaryotic type I DNA topoisomerase	0	DIRECT
ECR1 N-terminal domain-like	0	DIRECT
MPP-like	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
Alpha subunit of glutamate synthase, C-terminal domain	0	DIRECT
RraA-like	0	DIRECT
Clc chloride channel	0	DIRECT
LysM domain	0	DIRECT
HspBP1 domain	0	DIRECT
Outer arm dynein light chain 1	0	DIRECT
Enolase N-terminal domain-like	0	DIRECT
Sigma4 domain	0	DIRECT
N-acetyl-l-glutamate kinase	0	DIRECT
RuBisCO, small subunit	0	DIRECT
Ribosomal protein L22	0	DIRECT
HMGL-like	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
gamma-carbonic anhydrase-like	0	DIRECT
Hypothetical protein HI1317	0	DIRECT
R3H domain	0	DIRECT
Hypothetical protein YjiA, C-terminal domain	0	DIRECT
Tropomyosin	0	DIRECT
Diacylglycerol kinase-like	0	DIRECT
Succinyl-CoA synthetase, beta-chain, N-terminal domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
PdxS-like	0	DIRECT
Leucine aminopeptidase, C-terminal domain	0	DIRECT
Type 1 signal peptidase	0	DIRECT
DJ-1/PfpI	0	DIRECT
Allosteric chorismate mutase	0	DIRECT
GAT domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Sedlin (SEDL)	0	DIRECT
EXOSC10 HRDC domain-like	0	DIRECT
MIF-related	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	DIRECT
glucose-1-phosphate thymidylyltransferase	0	DIRECT
BphP N-terminal domain-like	0	DIRECT
CoA-binding domain	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
eIF1-like	0	DIRECT
Ribosomal protein L6	0	DIRECT
T7 RNA polymerase	0	DIRECT
GlmU C-terminal domain-like	0	DIRECT
DNA polymerase processivity factor	0	DIRECT
FAH	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
PsbO-like	0	DIRECT
E2F dimerization segment	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
WrbA-like	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Ribosomal protein L19	0	DIRECT
Head domain of nucleotide exchange factor GrpE	0	DIRECT
RecA protein, C-terminal domain	0	DIRECT
Formyltransferase	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Poly A polymerase head domain-like	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase dimerisation domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Translation initiation factor eIF4e	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
3-Methyladenine DNA glycosylase I (Tag)	0	DIRECT
Ferritin	0	DIRECT
Prokaryotic ribosomal protein L17	0	DIRECT
Class-II DAHP synthetase	0	DIRECT
PWWP domain	0	DIRECT
Epoxide hydrolase	0	DIRECT
monodomain cytochrome c	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), lid domain	0	DIRECT
Ribosomal protein L5	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
Ribosomal protein L37e	0	DIRECT
PX domain	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
Aspartokinase allosteric domain-like	0	DIRECT
Cobalamin-independent methionine synthase	0	DIRECT
beta-Phosphoglucomutase-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Tetrahydrofolate dehydrogenase/cyclohydrolase	0	DIRECT
XPC-binding domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Ribosomal protein S3 C-terminal domain	0	DIRECT
NHL repeat	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Hypoxia-inducible factor HIF ihhibitor (FIH1)	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Prokaryotic type KH domain (KH-domain type II)	0	DIRECT
Hypothetical protein TM1112	0	DIRECT
SufE-like	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
RibA-like	0	DIRECT
Phosphoglycerate kinase	0	DIRECT
N-terminal, heterodimerisation domain of RBP7 (RpoE)	0	DIRECT
PsbP-like	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Translational machinery components	0	DIRECT
Prefoldin	0	DIRECT
Pseudouridine synthase RsuA/RluD	0	DIRECT
Ribosomal protein S15	0	DIRECT
Nucleotide and nucleoside kinases	0	DIRECT
Mitochondrial carrier	0	DIRECT
Chromo domain	0	DIRECT
Cytochrome b5	0	DIRECT
Myf domain	0	DIRECT
Canonical RBD	0.000001467	DIRECT
Chaperone J-domain	0.000003106	DIRECT
WD40-repeat	0.00001974	DIRECT
G proteins	0.0000854	DIRECT