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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this AP term (Not in SDAP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Ammonium transporter	0	DIRECT
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	DIRECT
Ribosomal protein L13	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
CHY zinc finger-like	0	DIRECT
(Phosphotyrosine protein) phosphatases II	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
WW domain	0	DIRECT
Phosphofructokinase	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
ATP synthase (F1-ATPase), gamma subunit	0	DIRECT
EGF/Laminin	0	DIRECT
RibA-like	0	DIRECT
Elongation factor TFIIS domain 2	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
FKBP-like	0	DIRECT
Domain of the SRP/SRP receptor G-proteins	0	DIRECT
Chelatase	0	DIRECT
FAH	0	DIRECT
Alpha subunit of glutamate synthase, C-terminal domain	0	DIRECT
Mitochondrial glycoprotein MAM33-like	0	DIRECT
SIS domain	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
RplX-like	0	DIRECT
Preprotein translocase SecY subunit	0	DIRECT
Probable bacterial effector-binding domain	0	DIRECT
Ribonuclease Rh-like	0	DIRECT
Ribosomal protein L4	0	DIRECT
Electron transport accessory proteins	0	DIRECT
PLP-binding barrel	0	DIRECT
Prokaryotic type I DNA topoisomerase	0	DIRECT
Ferritin-like	0	DIRECT
Inorganic pyrophosphatase	0	DIRECT
LysM domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Galactose mutarotase-like	0	DIRECT
Thiolase-like	0	DIRECT
Trypsin-like serine proteases	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
PA domain	0	DIRECT
Ribosomal protein L14	0	DIRECT
STI-like	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
PAH2 domain	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Dimeric alpha+beta barrel	0	DIRECT
L28p-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Ribosomal protein S8	0	DIRECT
PAZ domain	0	DIRECT
DLC	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
Hypothetical protein YjiA, C-terminal domain	0	DIRECT
Ribosomal protein L11, C-terminal domain	0	DIRECT
DNA-glycosylase	0	DIRECT
Enolase C-terminal domain-like	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Sec7 domain	0	DIRECT
Enolase N-terminal domain-like	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
CYTH-like phosphatases	0	DIRECT
PapD-like	0	DIRECT
LeuD/IlvD-like	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
FMN-binding split barrel	0	DIRECT
Beta-D-glucan exohydrolase, C-terminal domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Oxidoreductase molybdopterin-binding domain	0	DIRECT
Nucleotidyltransferase	0	DIRECT
Ligand-binding domain in the NO signalling and Golgi transport	0	DIRECT
Ribosomal protein S10	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
DNA repair protein MutS, domain I	0	DIRECT
SBT domain	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0	DIRECT
Prokaryotic type KH domain (KH-domain type II)	0	DIRECT
PX domain	0	DIRECT
Phosphoglycerate kinase	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Chorismate mutase II	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Nicotinate/Quinolinate PRTase N-terminal domain-like	0	DIRECT
MurD-like peptide ligases, peptide-binding domain	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Clc chloride channel	0	DIRECT
BSD domain-like	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
HRDC-like	0	DIRECT
L9 N-domain-like	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
LigT-like	0	DIRECT
Folate-binding domain	0	DIRECT
AMPKBI-like	0	DIRECT
Zinc hairpin stack	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
Acetyl-CoA synthetase-like	0	DIRECT
Bromodomain	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
Lipocalins	0	DIRECT
Single hybrid motif	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
HMG-box	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Endosomal sorting complex assembly domain	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
Isochorismatase-like hydrolases	0	DIRECT
NHL repeat	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
PABC (PABP) domain	0	DIRECT
Cytochrome c	0	DIRECT
Globin-like	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
FAS1 domain	0	DIRECT
SAM/Pointed domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Lipase/lipooxygenase domain (PLAT/LH2 domain)	0	DIRECT
YrdC/RibB	0	DIRECT
RL5-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Granulin repeat	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Peptidyl-tRNA hydrolase-like	0	DIRECT
Ribosomal protein L16p/L10e	0	DIRECT
Peptide methionine sulfoxide reductase	0	DIRECT
Cyclophilin-like	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
Glucocorticoid receptor-like (DNA-binding domain)	0	DIRECT
BRCT domain	0	DIRECT
Prefoldin	0	DIRECT
Head domain of nucleotide exchange factor GrpE	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
ACT-like	0	DIRECT
DNA repair protein MutS, domain II	0	DIRECT
Tim10-like	0	DIRECT
Ribosomal protein S6	0	DIRECT
Peptidyl-tRNA hydrolase II	0	DIRECT
S13-like H2TH domain	0	DIRECT
RraA-like	0	DIRECT
Carbonic anhydrase	0	DIRECT
Nitrite and sulphite reductase 4Fe-4S domain-like	0	DIRECT
beta-N-acetylhexosaminidase-like domain	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
tRNA-binding arm	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
vWA-like	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
HesB-like domain	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
LEA14-like	0	DIRECT
Ribosomal protein L25-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Ribosomal protein L31e	0	DIRECT
Poly A polymerase C-terminal region-like	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Caspase-like	0	DIRECT
AF1104-like	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
Putative isomerase YbhE	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
RNase III domain-like	0	DIRECT
eIF1-like	0	DIRECT
ADC-like	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
N-terminal domain of the delta subunit of the F1F0-ATP synthase	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
Aldolase	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
PHL pollen allergen	0	DIRECT
SH3-domain	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
Tautomerase/MIF	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
Rhomboid-like	0	DIRECT
GTPase activation domain, GAP	0	DIRECT
At5g01610-like	0	DIRECT
Sigma2 domain of RNA polymerase sigma factors	0	DIRECT
Pentapeptide repeat-like	0	DIRECT
TATA-box binding protein-like	0	DIRECT
GAF domain-like	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
Expressed protein At2g23090/F21P24.15	0	DIRECT
LanC-like	0	DIRECT
AlbA-like	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
alpha/beta knot	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
SMR domain-like	0	DIRECT
Formyltransferase	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
DNA clamp	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
PDZ domain-like	0	DIRECT
Gamma-glutamyl cyclotransferase-like	0	DIRECT
Ribosomal protein L19 (L19e)	0	DIRECT
Fe-S cluster assembly (FSCA) domain-like	0	DIRECT
Ricin B-like lectins	0	DIRECT
GlnB-like	0	DIRECT
Casein kinase II beta subunit	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
GroES-like	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
Homodimeric domain of signal transducing histidine kinase	0	DIRECT
PreATP-grasp domain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Sigma3 and sigma4 domains of RNA polymerase sigma factors	0	DIRECT
HIT-like	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
Release factor	0	DIRECT
BEACH domain	0	DIRECT
Chromo domain-like	0	DIRECT
Prokaryotic ribosomal protein L17	0	DIRECT
Flavoproteins	0	DIRECT
SpoIIaa-like	0	DIRECT
ssDNA-binding transcriptional regulator domain	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Coiled-coil domain of nucleotide exchange factor GrpE	0	DIRECT
BolA-like	0	DIRECT
V-type ATPase subunit E-like	0	DIRECT
CO dehydrogenase flavoprotein C-terminal domain-like	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Preprotein translocase SecE subunit	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
Pentein	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
SCOP hierarchy in SUPERFAMILY	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Barwin-like endoglucanases	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
GINS helical bundle-like	0	DIRECT
N-terminal, heterodimerisation domain of RBP7 (RpoE)	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Phospholipase C/P1 nuclease	0	DIRECT
Ribosomal protein L39e	0	DIRECT
FF domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
Oxygen-evolving enhancer protein 3,	0	DIRECT
DEK C-terminal domain	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
D-aminoacid aminotransferase-like PLP-dependent enzymes	0	DIRECT
Ribosomal protein S2	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Smc hinge domain	0	DIRECT
Eukaryotic RPB5 N-terminal domain	0	DIRECT
Tetrahydrobiopterin biosynthesis enzymes-like	0	DIRECT
Lipoxigenase	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
Macro domain-like	0	DIRECT
Peptidase/esterase 'gauge' domain	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
GroEL apical domain-like	0	DIRECT
Signal peptide-binding domain	0	DIRECT
Radical SAM enzymes	0	DIRECT
TAZ domain	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
Serine metabolism enzymes domain	0	DIRECT
Plus3-like	0	DIRECT
MurD-like peptide ligases, catalytic domain	0	DIRECT
beta-carbonic anhydrase, cab	0	DIRECT
Rubredoxin-like	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Chalcone isomerase	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Trimeric LpxA-like enzymes	0	DIRECT
Mog1p/PsbP-like	0	DIRECT
RPB5-like RNA polymerase subunit	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Cullin homology domain	0	DIRECT
Ribosomal protein L29 (L29p)	0	DIRECT
ADC synthase	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
R3H domain	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
ClpP/crotonase	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
Saposin	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), lid domain	0	DIRECT
Cysteine alpha-hairpin motif	0	DIRECT
Scorpion toxin-like	0	DIRECT
XPC-binding domain	0	DIRECT
BAR/IMD domain-like	0	DIRECT

Family domains annotated to this AP term (Not in SDAP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
SBT domain	0	DIRECT
Folylpolyglutamate synthetase	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
RraA-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
HD domain	0	DIRECT
Inorganic pyrophosphatase	0	DIRECT
Glyoxalase I (lactoylglutathione lyase)	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
PWWP domain	0	DIRECT
Glycosyl transferases group 1	0	DIRECT
Macro domain	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
Ribosomal protein L39e	0	DIRECT
CAT-like	0	DIRECT
PABC (PABP) domain	0	DIRECT
MioX-like	0	DIRECT
Gamma-glutamyl cyclotransferase-like	0	DIRECT
Cyclin A/CDK2-associated p19, Skp2	0	DIRECT
Ribosomal protein L29 (L29p)	0	DIRECT
EDF1-like	0	DIRECT
Acetyl-CoA synthetase-like	0	DIRECT
PhzC/PhzF-like	0	DIRECT
DEK C-terminal domain	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
FF domain	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
MIF-related	0	DIRECT
Thioredoxin-like 2Fe-2S ferredoxin	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
DNA ligase/mRNA capping enzyme postcatalytic domain	0	DIRECT
Ribosomal protein S13	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Single-domain sulfurtransferase	0	DIRECT
Molybdenum-containing oxidoreductases-like dimerisation domain	0	DIRECT
HspBP1 domain	0	DIRECT
DNA repair protein MutS, domain I	0	DIRECT
B56-like	0	DIRECT
PX domain	0	DIRECT
BEACH domain	0	DIRECT
Signal peptide-binding domain	0	DIRECT
Poly A polymerase head domain-like	0	DIRECT
PAZ domain	0	DIRECT
HesB-like domain	0	DIRECT
Hypothetical protein YjiA, C-terminal domain	0	DIRECT
Ribosomal protein L31e	0	DIRECT
COMT-like	0	DIRECT
ATP-dependent DNA ligase catalytic domain	0	DIRECT
Smr domain	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
Nitrogenase iron protein-like	0	DIRECT
Adenain-like	0	DIRECT
Glucose 6-phosphate dehydrogenase-like	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
DJ-1/PfpI	0	DIRECT
Myf domain	0	DIRECT
ATP sulfurylase N-terminal domain	0	DIRECT
Ammonium transporter	0	DIRECT
Spermidine synthase	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
HCP-like	0	DIRECT
Adenosine-5'phosphosulfate kinase (APS kinase)	0	DIRECT
3-Methyladenine DNA glycosylase I (Tag)	0	DIRECT
Zinc hairpin stack	0	DIRECT
D-ribulose-5-phosphate 3-epimerase	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Mitochondrial glycoprotein MAM33-like	0	DIRECT
GroEL-like chaperone, apical domain	0	DIRECT
MSP-like	0	DIRECT
ZZ domain	0	DIRECT
Chromo barrel domain	0	DIRECT
CO dehydrogenase flavoprotein C-terminal domain-like	0	DIRECT
PCI domain (PINT motif)	0	DIRECT
BSD domain	0	DIRECT
beta-N-acetylhexosaminidase catalytic domain	0	DIRECT
Glycosyl hydrolases family 32 N-terminal domain	0	DIRECT
ADC synthase	0	DIRECT
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB	0	DIRECT
28-residue LRR	0	DIRECT
Cell cycle arrest protein BUB3	0	DIRECT
GlmU C-terminal domain-like	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
Release factor	0	DIRECT
Peptide methionine sulfoxide reductase	0	DIRECT
4HBT-like	0	DIRECT
Chalcone synthase-like	0	DIRECT
Sec7 domain	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
D-aminoacid aminotransferase-like PLP-dependent enzymes	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
Ribosomal protein L3	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
RuBisCo LSMT catalytic domain	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
DLC	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Peptidyl-tRNA hydrolase II	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
ATP sulfurylase catalytic domain	0	DIRECT
Cytochrome b5	0	DIRECT
PUA domain	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
Ribosomal protein L10e	0	DIRECT
Cytidylyltransferase	0	DIRECT
BolA-like	0	DIRECT
Methyl-CpG-binding domain, MBD	0	DIRECT
Oxysterol-binding protein	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Plant lipoxigenases	0	DIRECT
Homoserine dehydrogenase-like	0	DIRECT
GroEL chaperone, ATPase domain	0	DIRECT
Ribosomal protein L5	0	DIRECT
Prolyl oligopeptidase, N-terminal domain	0	DIRECT
2Fe-2S ferredoxin-related	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Phytochrome-specific domain	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
Linker histone H1/H5	0	DIRECT
Beta-D-glucan exohydrolase, C-terminal domain	0	DIRECT
PAPS reductase-like	0	DIRECT
HMG-box	0	DIRECT
Prolyl oligopeptidase, C-terminal domain	0	DIRECT
At5g01610-like	0	DIRECT
eIF5a N-terminal domain-like	0	DIRECT
Subtilase propeptides/inhibitors	0	DIRECT
Preprotein translocase SecE subunit	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Poly A polymerase C-terminal region-like	0	DIRECT
Allosteric chorismate mutase	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Pollen allergen PHL P 1 N-terminal domain	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
RPB5	0	DIRECT
Ribosomal protein S2	0	DIRECT
RibA-like	0	DIRECT
Pentapeptide repeats	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Shikimate kinase (AroK)	0	DIRECT
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0	DIRECT
N-acetyl-l-glutamate kinase	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	0	DIRECT
Transcriptional coactivator PC4 C-terminal domain	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Anti-sigma factor antagonist SpoIIaa	0	DIRECT
SH3-domain	0	DIRECT
Kunitz (STI) inhibitors	0	DIRECT
Phosphoenolpyruvate carboxylase	0	DIRECT
SufE-like	0	DIRECT
alpha-mannosidase	0	DIRECT
PaaI/YdiI-like	0	DIRECT
GDI-like N domain	0	DIRECT
Nuclear movement domain	0	DIRECT
Rhomboid-like	0	DIRECT
Ribosomal S5 protein, N-terminal domain	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Histidine kinase	0	DIRECT
WW domain	0	DIRECT
Isochorismatase-like hydrolases	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
MPP-like	0	DIRECT
Ribosomal protein S15	0	DIRECT
HIT (HINT, histidine triad) family of protein kinase-interacting proteins	0	DIRECT
Alpha subunit of glutamate synthase, C-terminal domain	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
Phosphofructokinase	0	DIRECT
AlkB-like	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
Formyltransferase	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
LIM domain	0	DIRECT
FAS1 domain	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), lid domain	0	DIRECT
Casein kinase II beta subunit	0	DIRECT
HAL/PAL-like	0	DIRECT
Receiver domain of the ethylene receptor	0	DIRECT
C5 cytosine-specific DNA methylase, DCM	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
Starch-binding domain	0	DIRECT
SerA intervening domain-like	0	DIRECT
Thiolase-related	0	DIRECT
beta-carbonic anhydrase, cab	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
RWD domain	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
monodomain cytochrome c	0	DIRECT
Pyruvate oxidase and decarboxylase PP module	0	DIRECT
Tim10/DDP	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
Tail specific protease, catalytic domain	0	DIRECT
Coiled-coil domain of nucleotide exchange factor GrpE	0	DIRECT
Carbon-carbon bond hydrolase	0	DIRECT
FucT-like	0	DIRECT
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	DIRECT
Enolase	0	DIRECT
Trehalose-6-phosphate synthase, OtsA	0	DIRECT
Ribosomal protein L13	0	DIRECT
GAPDH-like	0	DIRECT
Gastric lipase	0	DIRECT
Ring hydroxylating alpha subunit ISP domain	0	DIRECT
Pectate lyase-like	0	DIRECT
PDI-like	0	DIRECT
Prokaryotic proteases	0	DIRECT
Formate/glycerate dehydrogenases, substrate-binding domain	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
P1 nuclease	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
PA domain	0	DIRECT
LON domain-like	0	DIRECT
Pyruvate oxidase and decarboxylase Pyr module	0	DIRECT
Crotonase-like	0	DIRECT
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Ribosomal protein L19 (L19e)	0	DIRECT
Hypothetical protein At2g34160	0	DIRECT
glucose-1-phosphate thymidylyltransferase	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
Plant transcriptional regulator PBF-2	0	DIRECT
Oxidoreductase molybdopterin-binding domain	0	DIRECT
STAR domain	0	DIRECT
Ribosomal protein S8	0	DIRECT
Ribonuclease Rh-like	0	DIRECT
Swaposin	0	DIRECT
GAT domain	0	DIRECT
RplX-like	0	DIRECT
Cytochrome p450 reductase N-terminal domain-like	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
beta-Galactosidase/glucuronidase, N-terminal domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Prokaryotic ribosomal protein L17	0	DIRECT
HMGL-like	0	DIRECT
Heme-dependent catalases	0	DIRECT
Prokaryotic type KH domain (KH-domain type II)	0	DIRECT
GMC oxidoreductases	0	DIRECT
NHL repeat	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
Diacylglycerol kinase-like	0	DIRECT
Translational machinery components	0	DIRECT
Clp protease, ClpP subunit	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
UBX domain	0	DIRECT
N-terminal, heterodimerisation domain of RBP7 (RpoE)	0	DIRECT
NagB-like	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
Sedlin (SEDL)	0	DIRECT
ATP synthase (F1-ATPase), gamma subunit	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), catalytic domain	0	DIRECT
PNP-oxidase like	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Plant defensins	0	DIRECT
Glycosyl hydrolases family 32 C-terminal domain	0	DIRECT
RelA/SpoT domain	0	DIRECT
Rubredoxin	0	DIRECT
RNase Z-like	0	DIRECT
MutT-like	0	DIRECT
SIAH, seven in absentia homolog	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Neurolysin-like	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
BAR domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Chromo domain	0	DIRECT
Cystathionine synthase-like	0	DIRECT
WrbA-like	0	DIRECT
Transcription factor IIB (TFIIB), core domain	0	DIRECT
IF2B-like	0	DIRECT
V-type ATPase subunit E	0	DIRECT
Amylase, catalytic domain	0	DIRECT
LysM domain	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
G domain-linked domain	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
XPC-binding domain	0	DIRECT
Gtf glycosyltransferase	0	DIRECT
FAH	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
L23p	0	DIRECT
Ribosomal protein L11, C-terminal domain	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
Gelsolin-like	0	DIRECT
Ribosomal protein L19	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
YicI N-terminal domain-like	0	DIRECT
Homodimeric domain of signal transducing histidine kinase	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
Choline kinase	0	DIRECT
Aminoacid dehydrogenases	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
SCF ubiquitin ligase complex WHB domain	0	DIRECT
beta-Phosphoglucomutase-like	0	DIRECT
Ribosomal proteins L24p and L21e	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Tryptophan biosynthesis enzymes	0	DIRECT
NagZ-like	0	DIRECT
Galactosyltransferase LgtC	0	DIRECT
Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain	0	DIRECT
RNase III catalytic domain-like	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
CAF1-like ribonuclease	0	DIRECT
Eukaryotic RPB5 N-terminal domain	0	DIRECT
LEA14-like	0	DIRECT
IPP isomerase-like	0	DIRECT
Cystatins	0	DIRECT
RNB domain-like	0	DIRECT
(Glycosyl)asparaginase	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
GARP response regulators	0	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Acyl-ACP thioesterase-like	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Putative glucosidase YicI, domain 3	0	DIRECT
DNase I-like	0	DIRECT
Carboxylesterase	0	DIRECT
HEAT repeat	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
Predicted hydrolases Cof	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Ferritin	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
Prefoldin	0	DIRECT
Enolase N-terminal domain-like	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
Protein prenyltransferases	0	DIRECT
Ribosomal protein S27e	0	DIRECT
HAT/Suf repeat	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Thioesterases	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Carbonic anhydrase	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase dimerisation domain	0	DIRECT
Cofactor-dependent phosphoglycerate mutase	0	DIRECT
Band 7/SPFH domain	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
MYND zinc finger	0	DIRECT
Aldose 1-epimerase (mutarotase)	0	DIRECT
GroEL-like chaperone, intermediate domain	0	DIRECT
NadC C-terminal domain-like	0	DIRECT
AMPKBI-like	0	DIRECT
Cytokinin dehydrogenase 1	0	DIRECT
Rps19E-like	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Sigma4 domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
RhoGDI-like	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
GABARAP-like	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
Glycerol-3-phosphate dehydrogenase	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Nitrite and sulphite reductase 4Fe-4S domain-like	0	DIRECT
E-set domains of sugar-utilizing enzymes	0	DIRECT
Hypothetical protein HI1317	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
Lipoxigenase N-terminal domain	0	DIRECT
Isoprenyl diphosphate synthases	0	DIRECT
Succinyl-CoA synthetase, beta-chain, N-terminal domain	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
DNA repair glycosylase, 2 C-terminal domains	0	DIRECT
Domain of the SRP/SRP receptor G-proteins	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain	0	DIRECT
GroES	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
5' nucleotidase-like	0	DIRECT
NadC N-terminal domain-like	0	DIRECT
Reductases	0	DIRECT
gamma-carbonic anhydrase-like	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
Phosphoenolpyruvate mutase/Isocitrate lyase-like	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
TRM1-like	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Bromodomain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Plant stress-induced protein	0	DIRECT
Class I aldolase	0	DIRECT
SWIRM domain	0	DIRECT
Serine acetyltransferase	0	DIRECT
Prokaryotic type I DNA topoisomerase	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Oxygen-evolving enhancer protein 3,	0	DIRECT
BphP N-terminal domain-like	0	DIRECT
Glyoxalase II (hydroxyacylglutathione hydrolase)	0	DIRECT
Sigma2 domain of RNA polymerase sigma factors	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
Internalin LRR domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
LeuD-like	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
CHY zinc finger	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
CoA-binding domain	0	DIRECT
Pathogenesis-related protein 10 (PR10)-like	0	DIRECT
Ribosomal protein L4	0	DIRECT
VHS domain	0	DIRECT
PAH2 domain	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Cullin repeat	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
Smc hinge domain	0	DIRECT
Peptidyl-tRNA hydrolase-like	0	DIRECT
Chalcone isomerase	0	DIRECT
TAZ domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
RNA polymerase II subunit RBP4 (RpoF)	0	DIRECT
rRNA adenine dimethylase-like	0	DIRECT
FKBP immunophilin/proline isomerase	0	DIRECT
AF1104-like	0	DIRECT
La domain	0	DIRECT
Hypothetical protein TM1112	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Clc chloride channel	0	DIRECT
Ribosomal protein L14	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
Pyruvate oxidase and decarboxylase, middle domain	0	DIRECT
Molybdenum cofactor biosynthesis protein MoeB	0	DIRECT
SOUL heme-binding protein	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Preprotein translocase SecY subunit	0	DIRECT
Cullin homology domain	0	DIRECT
Hermes transposase-like	0	DIRECT
Granulin repeat	0	DIRECT
Glycosyl hydrolases family 35 catalytic domain	0	DIRECT
E2F dimerization segment	0	DIRECT
Ribonucleotide reductase-like	0	DIRECT
Elongation factor TFIIS domain 2	0	DIRECT
Dihydrodipicolinate reductase-like	0	DIRECT
eIF1-like	0	DIRECT
PHL pollen allergen	0	DIRECT
NifU C-terminal domain-like	0	DIRECT
Class-II DAHP synthetase	0	DIRECT
GAF domain	0	DIRECT
Aspartokinase allosteric domain-like	0	DIRECT
R3H domain	0	DIRECT
BCR-homology GTPase activation domain (BH-domain)	0	DIRECT
Phosphoglycerate kinase	0	DIRECT
Calnexin/calreticulin	0	DIRECT
PsbP-like	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
LplA-like	0	DIRECT
RNA-polymerase beta	0	DIRECT
DNA polymerase processivity factor	0	DIRECT
Head domain of nucleotide exchange factor GrpE	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
Ribosomal protein L37e	0	DIRECT
Plus3	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Pseudouridine synthase II TruB	0	DIRECT
SpoU-like RNA 2'-O ribose methyltransferase	0	DIRECT
Ran-binding domain	0	DIRECT
Ribosomal protein S6	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT