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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this AP term (Not in SDAP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Oxidoreductase molybdopterin-binding domain	0	DIRECT
ACT-like	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
Thiolase-like	0	DIRECT
Chelatase	0	DIRECT
TATA-box binding protein-like	0	DIRECT
Ribosomal protein L25-like	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
RL5-like	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Ribosomal protein L16p/L10e	0	DIRECT
Radical SAM enzymes	0	DIRECT
Caspase-like	0	DIRECT
YrdC/RibB	0	DIRECT
Peptidyl-tRNA hydrolase-like	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
eIF1-like	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Ribosomal protein L31e	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
HesB-like domain	0	DIRECT
RNase III domain-like	0	DIRECT
V-type ATPase subunit E-like	0	DIRECT
Nicotinate/Quinolinate PRTase N-terminal domain-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
Coiled-coil domain of nucleotide exchange factor GrpE	0	DIRECT
Folate-binding domain	0	DIRECT
ADC-like	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
NagB/RpiA/CoA transferase-like	0	DIRECT
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	DIRECT
Prefoldin	0	DIRECT
SMR domain-like	0	DIRECT
Chalcone isomerase	0	DIRECT
TAZ domain	0	DIRECT
Ligand-binding domain in the NO signalling and Golgi transport	0	DIRECT
R3H domain	0	DIRECT
STI-like	0	DIRECT
(Phosphotyrosine protein) phosphatases II	0	DIRECT
Ribosomal protein S2	0	DIRECT
Enolase C-terminal domain-like	0	DIRECT
Ribosomal protein L19 (L19e)	0	DIRECT
Ribosomal protein S8	0	DIRECT
Ricin B-like lectins	0	DIRECT
Ribosomal protein L13	0	DIRECT
Rhodanese/Cell cycle control phosphatase	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
LigT-like	0	DIRECT
RplX-like	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
PreATP-grasp domain	0	DIRECT
Pentein	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Zinc hairpin stack	0	DIRECT
Ribosomal protein L1	0	DIRECT
Supernatant protein factor (SPF), C-terminal domain	0	DIRECT
Carbonic anhydrase	0	DIRECT
Plus3-like	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
Ferritin-like	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Ribosomal protein L11, C-terminal domain	0	DIRECT
Sigma3 and sigma4 domains of RNA polymerase sigma factors	0	DIRECT
AN1-like Zinc finger	0	DIRECT
Smc hinge domain	0	DIRECT
Lipase/lipooxygenase domain (PLAT/LH2 domain)	0	DIRECT
Glucocorticoid receptor-like (DNA-binding domain)	0	DIRECT
Inorganic pyrophosphatase	0	DIRECT
GlnB-like	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
Cyclophilin-like	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
Pentapeptide repeat-like	0	DIRECT
Acid phosphatase/Vanadium-dependent haloperoxidase	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
LDH C-terminal domain-like	0	DIRECT
Trypsin-like serine proteases	0	DIRECT
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
Ribosomal protein L29 (L29p)	0	DIRECT
Chorismate mutase II	0	DIRECT
Ammonium transporter	0	DIRECT
PHL pollen allergen	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
Sec63 N-terminal domain-like	0	DIRECT
Galactose mutarotase-like	0	DIRECT
Ribonuclease Rh-like	0	DIRECT
PAZ domain	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
Cullin homology domain	0	DIRECT
FAS1 domain	0	DIRECT
L9 N-domain-like	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Globin-like	0	DIRECT
AF1104-like	0	DIRECT
Oxysterol-binding protein-like	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
Rhomboid-like	0	DIRECT
ATP synthase (F1-ATPase), gamma subunit	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
MurD-like peptide ligases, catalytic domain	0	DIRECT
DEK C-terminal domain	0	DIRECT
HMG-box	0	DIRECT
Preprotein translocase SecY subunit	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
PLP-binding barrel	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Signal peptide-binding domain	0	DIRECT
WW domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
N-terminal, heterodimerisation domain of RBP7 (RpoE)	0	DIRECT
Phosphofructokinase	0	DIRECT
Barwin-like endoglucanases	0	DIRECT
Cysteine alpha-hairpin motif	0	DIRECT
Release factor	0	DIRECT
XPC-binding domain	0	DIRECT
Phosphoglycerate mutase-like	0	DIRECT
Acetyl-CoA synthetase-like	0	DIRECT
GAF domain-like	0	DIRECT
RPB5-like RNA polymerase subunit	0	DIRECT
Isochorismatase-like hydrolases	0	DIRECT
Electron transport accessory proteins	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
Endosomal sorting complex assembly domain	0	DIRECT
beta-N-acetylhexosaminidase-like domain	0	DIRECT
Ribosomal protein S6	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
Prokaryotic ribosomal protein L17	0	DIRECT
Cytochrome c	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
beta-carbonic anhydrase, cab	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Probable bacterial effector-binding domain	0	DIRECT
Dimeric alpha+beta barrel	0	DIRECT
L28p-like	0	DIRECT
SBT domain	0	DIRECT
LanC-like	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Homodimeric domain of signal transducing histidine kinase	0	DIRECT
GroES-like	0	DIRECT
PAH2 domain	0	DIRECT
AMPKBI-like	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
Nitrite and sulphite reductase 4Fe-4S domain-like	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Bromodomain	0	DIRECT
Trimeric LpxA-like enzymes	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Ribosomal protein L4	0	DIRECT
Putative isomerase YbhE	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
EGF/Laminin	0	DIRECT
Peptide methionine sulfoxide reductase	0	DIRECT
Prokaryotic type I DNA topoisomerase	0	DIRECT
DNA clamp	0	DIRECT
RibA-like	0	DIRECT
PA domain	0	DIRECT
Prokaryotic type KH domain (KH-domain type II)	0	DIRECT
Head domain of nucleotide exchange factor GrpE	0	DIRECT
Peptidyl-tRNA hydrolase II	0	DIRECT
HRDC-like	0	DIRECT
Formyltransferase	0	DIRECT
DNA repair protein MutS, domain II	0	DIRECT
Preprotein translocase SecE subunit	0	DIRECT
PX domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
NHL repeat	0	DIRECT
FAH	0	DIRECT
Tautomerase/MIF	0	DIRECT
Lipoxigenase	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Enolase N-terminal domain-like	0	DIRECT
Sec7 domain	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
GTPase activation domain, GAP	0	DIRECT
BEACH domain	0	DIRECT
Aldolase	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
Metallo-hydrolase/oxidoreductase	0	DIRECT
BSD domain-like	0	DIRECT
Oxygen-evolving enhancer protein 3,	0	DIRECT
Chromo domain-like	0	DIRECT
FMN-binding split barrel	0	DIRECT
S13-like H2TH domain	0	DIRECT
Peptidase/esterase 'gauge' domain	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
FF domain	0	DIRECT
D-aminoacid aminotransferase-like PLP-dependent enzymes	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Macro domain-like	0	DIRECT
Domain of the SRP/SRP receptor G-proteins	0	DIRECT
SCOP hierarchy in SUPERFAMILY	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Flavoproteins	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Saposin	0	DIRECT
Granulin repeat	0	DIRECT
ADC synthase	0	DIRECT
AlbA-like	0	DIRECT
Sigma2 domain of RNA polymerase sigma factors	0	DIRECT
GroEL apical domain-like	0	DIRECT
BRCT domain	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
Nucleotidyltransferase	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
BolA-like	0	DIRECT
alpha/beta knot	0	DIRECT
Mitochondrial glycoprotein MAM33-like	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), lid domain	0	DIRECT
Phospholipase C/P1 nuclease	0	DIRECT
RraA-like	0	DIRECT
CYTH-like phosphatases	0	DIRECT
BAR/IMD domain-like	0	DIRECT
Scorpion toxin-like	0	DIRECT
HIT/MYND zinc finger-like	0	DIRECT
N-terminal domain of the delta subunit of the F1F0-ATP synthase	0	DIRECT
NAD(P)-linked oxidoreductase	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
SIS domain	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Clc chloride channel	0	DIRECT
EF-G C-terminal domain-like	0	DIRECT
tRNA-binding arm	0	DIRECT
SH3-domain	0	DIRECT
PAP/OAS1 substrate-binding domain	0	DIRECT
Beta-D-glucan exohydrolase, C-terminal domain	0	DIRECT
NAD kinase/diacylglycerol kinase-like	0	DIRECT
Lipocalins	0	DIRECT
At5g01610-like	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
FKBP-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
Poly A polymerase C-terminal region-like	0	DIRECT
SAM/Pointed domain	0	DIRECT
Serine metabolism enzymes domain	0	DIRECT
CO dehydrogenase flavoprotein C-terminal domain-like	0	DIRECT
PapD-like	0	DIRECT
Elongation factor TFIIS domain 2	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
ssDNA-binding transcriptional regulator domain	0	DIRECT
Mog1p/PsbP-like	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
Tim10-like	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
SpoIIaa-like	0	DIRECT
Phosphoglycerate kinase	0	DIRECT
DNA-glycosylase	0	DIRECT
Casein kinase II beta subunit	0	DIRECT
ClpP/crotonase	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
vWA-like	0	DIRECT
MurD-like peptide ligases, peptide-binding domain	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Rubredoxin-like	0	DIRECT
LeuD/IlvD-like	0	DIRECT
Tetrahydrobiopterin biosynthesis enzymes-like	0	DIRECT
Ribosomal protein L14	0	DIRECT
DLC	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
CHY zinc finger-like	0	DIRECT
Hypothetical protein YjiA, C-terminal domain	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
Eukaryotic RPB5 N-terminal domain	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
Alpha subunit of glutamate synthase, C-terminal domain	0	DIRECT
GINS helical bundle-like	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	0	DIRECT
Gamma-glutamyl cyclotransferase-like	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0	DIRECT
Expressed protein At2g23090/F21P24.15	0	DIRECT
DNA repair protein MutS, domain I	0	DIRECT
Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
PDZ domain-like	0	DIRECT
Ribosomal protein L39e	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
LysM domain	0	DIRECT
HIT-like	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
LEA14-like	0	DIRECT
Single hybrid motif	0	DIRECT
Fe-S cluster assembly (FSCA) domain-like	0	DIRECT

Family domains annotated to this AP term (Not in SDAP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
FKBP immunophilin/proline isomerase	0	DIRECT
DNase I-like	0	DIRECT
Succinyl-CoA synthetase, beta-chain, N-terminal domain	0	DIRECT
beta-N-acetylhexosaminidase catalytic domain	0	DIRECT
LDH N-terminal domain-like	0	DIRECT
GAPDH-like	0	DIRECT
Molybdenum cofactor biosynthesis protein MoeB	0	DIRECT
Ribosomal protein S6	0	DIRECT
Swaposin	0	DIRECT
Oxidoreductase molybdopterin-binding domain	0	DIRECT
CO dehydrogenase molybdoprotein N-domain-like	0	DIRECT
N-acetyl-l-glutamate kinase	0	DIRECT
Sigma2 domain of RNA polymerase sigma factors	0	DIRECT
CO dehydrogenase flavoprotein C-terminal domain-like	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
PNP-oxidase like	0	DIRECT
LIM domain	0	DIRECT
BAR domain	0	DIRECT
Phosphoenolpyruvate carboxylase	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
ATP-dependent DNA ligase catalytic domain	0	DIRECT
Myf domain	0	DIRECT
Prokaryotic ribosomal protein L17	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Phosphoglycerate kinase	0	DIRECT
Dual specificity phosphatase-like	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
LysM domain	0	DIRECT
beta-carbonic anhydrase, cab	0	DIRECT
D-ribulose-5-phosphate 3-epimerase	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
AlkB-like	0	DIRECT
Adenain-like	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Thioredoxin-like 2Fe-2S ferredoxin	0	DIRECT
Beta-D-glucan exohydrolase, C-terminal domain	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
TRM1-like	0	DIRECT
PAPS reductase-like	0	DIRECT
GroEL-like chaperone, intermediate domain	0	DIRECT
Elongation factor TFIIS domain 2	0	DIRECT
Oxysterol-binding protein	0	DIRECT
SufE-like	0	DIRECT
Calcium ATPase, transmembrane domain M	0	DIRECT
DLC	0	DIRECT
SBT domain	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
Ribosomal protein S27e	0	DIRECT
DNA ligase/mRNA capping enzyme postcatalytic domain	0	DIRECT
Peptidyl-tRNA hydrolase II	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
Cytokinin dehydrogenase 1	0	DIRECT
Serine acetyltransferase	0	DIRECT
Glycerol-3-phosphate transporter	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase dimerisation domain	0	DIRECT
Macro domain	0	DIRECT
HAT/Suf repeat	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
Prokaryotic type I DNA topoisomerase	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
Ribosomal protein L4	0	DIRECT
CO dehydrogenase ISP C-domain like	0	DIRECT
Glycosyl transferases group 1	0	DIRECT
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0	DIRECT
RplX-like	0	DIRECT
HesB-like domain	0	DIRECT
3-Methyladenine DNA glycosylase I (Tag)	0	DIRECT
Protein prenyltransferases	0	DIRECT
Methyl-CpG-binding domain, MBD	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Zinc hairpin stack	0	DIRECT
Ribosomal protein L10e	0	DIRECT
GABARAP-like	0	DIRECT
PX domain	0	DIRECT
RhoGDI-like	0	DIRECT
Galactosyltransferase LgtC	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
RNase Z-like	0	DIRECT
NifU C-terminal domain-like	0	DIRECT
Ribosomal protein L29 (L29p)	0	DIRECT
Allosteric chorismate mutase	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), catalytic domain	0	DIRECT
Aldose 1-epimerase (mutarotase)	0	DIRECT
Rubredoxin	0	DIRECT
Glycerol-3-phosphate dehydrogenase	0	DIRECT
Plant transcriptional regulator PBF-2	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Putative glucosidase YicI, domain 3	0	DIRECT
Rps19E-like	0	DIRECT
UBX domain	0	DIRECT
Homoserine dehydrogenase-like	0	DIRECT
B56-like	0	DIRECT
Prokaryotic type KH domain (KH-domain type II)	0	DIRECT
P1 nuclease	0	DIRECT
HD domain	0	DIRECT
Aldo-keto reductases (NADP)	0	DIRECT
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0	DIRECT
Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain	0	DIRECT
STAR domain	0	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0	DIRECT
Homodimeric domain of signal transducing histidine kinase	0	DIRECT
Cytochrome p450 reductase N-terminal domain-like	0	DIRECT
Gamma-glutamyl cyclotransferase-like	0	DIRECT
Cryptochrome/photolyase, N-terminal domain	0	DIRECT
Prolyl oligopeptidase, C-terminal domain	0	DIRECT
GAF domain	0	DIRECT
HCP-like	0	DIRECT
Cytidylyltransferase	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
Thiolase-related	0	DIRECT
Receiver domain of the ethylene receptor	0	DIRECT
RNB domain-like	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
SOUL heme-binding protein	0	DIRECT
Enolase	0	DIRECT
YicI catalytic domain-like	0	DIRECT
Histidine kinase	0	DIRECT
PAH2 domain	0	DIRECT
SpoU-like RNA 2'-O ribose methyltransferase	0	DIRECT
Ammonium transporter	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Ribosomal protein L5	0	DIRECT
Neurolysin-like	0	DIRECT
GAT domain	0	DIRECT
Phytochrome-specific domain	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
Ribosomal protein L11, C-terminal domain	0	DIRECT
FF domain	0	DIRECT
PCI domain (PINT motif)	0	DIRECT
Peptidyl-tRNA hydrolase-like	0	DIRECT
Isochorismatase-like hydrolases	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Cystatins	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
IF2B-like	0	DIRECT
WW domain	0	DIRECT
MSP-like	0	DIRECT
DEK C-terminal domain	0	DIRECT
CO dehydrogenase flavoprotein N-terminal domain-like	0	DIRECT
Pectate lyase-like	0	DIRECT
PDI-like	0	DIRECT
Preprotein translocase SecE subunit	0	DIRECT
Ferritin	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
BolA-like	0	DIRECT
HMGL-like	0	DIRECT
DNA repair glycosylase, 2 C-terminal domains	0	DIRECT
GARP response regulators	0	DIRECT
Hypothetical protein TM1112	0	DIRECT
ZZ domain	0	DIRECT
Ribonuclease Rh-like	0	DIRECT
BSD domain	0	DIRECT
Starch-binding domain	0	DIRECT
Phosphofructokinase	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
HMG-box	0	DIRECT
VHS domain	0	DIRECT
Band 7/SPFH domain	0	DIRECT
RWD domain	0	DIRECT
NadC C-terminal domain-like	0	DIRECT
Amidase signature (AS) enzymes	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
AN1-like Zinc finger	0	DIRECT
NadC N-terminal domain-like	0	DIRECT
Formyltransferase	0	DIRECT
WrbA-like	0	DIRECT
Pyruvate oxidase and decarboxylase PP module	0	DIRECT
Carboxylesterase	0	DIRECT
GroEL-like chaperone, apical domain	0	DIRECT
Class-II DAHP synthetase	0	DIRECT
LeuD-like	0	DIRECT
RNA methyltransferase FtsJ	0	DIRECT
Glucose 6-phosphate dehydrogenase-like	0	DIRECT
PWWP domain	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
R3H domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
EDF1-like	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Casein kinase II beta subunit	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0	DIRECT
Transcriptional coactivator PC4 C-terminal domain	0	DIRECT
Heme-dependent catalases	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
NagZ-like	0	DIRECT
V-type ATPase subunit E	0	DIRECT
IPP isomerase-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Plant stress-induced protein	0	DIRECT
Reductases	0	DIRECT
PABC (PABP) domain	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Acetyl-CoA synthetase-like	0	DIRECT
Ran-binding domain	0	DIRECT
Isoprenyl diphosphate synthases	0	DIRECT
GroES	0	DIRECT
N-terminal, heterodimerisation domain of RBP7 (RpoE)	0	DIRECT
HEAT repeat	0	DIRECT
Nitrite and sulphite reductase 4Fe-4S domain-like	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	0	DIRECT
Amylase, catalytic domain	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
4HBT-like	0	DIRECT
Translational machinery components	0	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
Ribosomal protein L19	0	DIRECT
MPP-like	0	DIRECT
Cullin repeat	0	DIRECT
RNA polymerase II subunit RBP4 (RpoF)	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
MioX-like	0	DIRECT
Lipoxigenase N-terminal domain	0	DIRECT
Poly A polymerase head domain-like	0	DIRECT
Cytochrome b5	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Release factor	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
AMPKBI-like	0	DIRECT
PhzC/PhzF-like	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
Prefoldin	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
NagB-like	0	DIRECT
DNA polymerase processivity factor	0	DIRECT
FAS1 domain	0	DIRECT
DNA repair protein MutS, domain I	0	DIRECT
Smr domain	0	DIRECT
At5g01610-like	0	DIRECT
HAL/PAL-like	0	DIRECT
Hypothetical protein YjiA, C-terminal domain	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
SH3-domain	0	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
FAH	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Preprotein translocase SecY subunit	0	DIRECT
Ribosomal proteins L24p and L21e	0	DIRECT
C5 cytosine-specific DNA methylase, DCM	0	DIRECT
Ribosomal protein S8	0	DIRECT
Phosphoenolpyruvate mutase/Isocitrate lyase-like	0	DIRECT
Pseudouridine synthase II TruB	0	DIRECT
LEA14-like	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Chalcone isomerase	0	DIRECT
BC C-terminal domain-like	0	DIRECT
RuBisCo LSMT catalytic domain	0	DIRECT
GroEL chaperone, ATPase domain	0	DIRECT
Domain of the SRP/SRP receptor G-proteins	0	DIRECT
SIAH, seven in absentia homolog	0	DIRECT
Gastric lipase	0	DIRECT
Glyoxalase II (hydroxyacylglutathione hydrolase)	0	DIRECT
Cell cycle arrest protein BUB3	0	DIRECT
28-residue LRR	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
The spindle assembly checkpoint protein mad2	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
Head domain of nucleotide exchange factor GrpE	0	DIRECT
Hypothetical protein At2g34160	0	DIRECT
Hypothetical protein HI1317	0	DIRECT
Sec7 domain	0	DIRECT
Subtilase propeptides/inhibitors	0	DIRECT
PUA domain	0	DIRECT
Choline kinase	0	DIRECT
5' nucleotidase-like	0	DIRECT
eIF5a N-terminal domain-like	0	DIRECT
Granulin repeat	0	DIRECT
Glycosyl hydrolases family 32 C-terminal domain	0	DIRECT
Diacylglycerol kinase-like	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
L23p	0	DIRECT
Ribosomal protein L1	0	DIRECT
E2F dimerization segment	0	DIRECT
(Glycosyl)asparaginase	0	DIRECT
beta-Galactosidase/glucuronidase, N-terminal domain	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
EF-G/eEF-2 domains III and V	0	DIRECT
Ribosomal protein S15	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
Glyoxalase I (lactoylglutathione lyase)	0	DIRECT
Pentapeptide repeats	0	DIRECT
Dihydrodipicolinate reductase-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Crotonase-like	0	DIRECT
GlmU C-terminal domain-like	0	DIRECT
Plus3	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
E-set domains of sugar-utilizing enzymes	0	DIRECT
Aspartokinase allosteric domain-like	0	DIRECT
LON domain-like	0	DIRECT
eIF1-like	0	DIRECT
Enolase N-terminal domain-like	0	DIRECT
Mitochondrial glycoprotein MAM33-like	0	DIRECT
BphP N-terminal domain-like	0	DIRECT
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
Chromo barrel domain	0	DIRECT
Molybdenum-containing oxidoreductases-like dimerisation domain	0	DIRECT
Acyl-ACP thioesterase-like	0	DIRECT
Peptide methionine sulfoxide reductase	0	DIRECT
Plant lipoxigenases	0	DIRECT
Anti-sigma factor antagonist SpoIIaa	0	DIRECT
Signal peptide-binding domain	0	DIRECT
Transcription factor IIB (TFIIB), core domain	0	DIRECT
rRNA adenine dimethylase-like	0	DIRECT
La domain	0	DIRECT
Ring hydroxylating alpha subunit ISP domain	0	DIRECT
LplA-like	0	DIRECT
MYND zinc finger	0	DIRECT
Ribosomal protein L19 (L19e)	0	DIRECT
Bromodomain	0	DIRECT
RNA-polymerase beta	0	DIRECT
Trehalose-6-phosphate synthase, OtsA	0	DIRECT
Plant defensins	0	DIRECT
N-acetyl transferase, NAT	0	DIRECT
HIT (HINT, histidine triad) family of protein kinase-interacting proteins	0	DIRECT
BCR-homology GTPase activation domain (BH-domain)	0	DIRECT
NHL repeat	0	DIRECT
Ribosomal protein L14	0	DIRECT
Nitrogenase iron protein-like	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), lid domain	0	DIRECT
RelA/SpoT domain	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Pathogenesis-related protein 10 (PR10)-like	0	DIRECT
SerA intervening domain-like	0	DIRECT
MutT-like	0	DIRECT
GMC oxidoreductases	0	DIRECT
Poly A polymerase C-terminal region-like	0	DIRECT
Oxygen-evolving enhancer protein 3,	0	DIRECT
Gtf glycosyltransferase	0	DIRECT
Class I aldolase	0	DIRECT
RNase III catalytic domain-like	0	DIRECT
GDI-like N domain	0	DIRECT
Gelsolin-like	0	DIRECT
TAZ domain	0	DIRECT
Spermidine synthase	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Kunitz (STI) inhibitors	0	DIRECT
Single-domain sulfurtransferase	0	DIRECT
ATP sulfurylase catalytic domain	0	DIRECT
Ribosomal protein L31e	0	DIRECT
Pollen allergen PHL P 1 N-terminal domain	0	DIRECT
ADC synthase	0	DIRECT
Chromo domain	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Cyclin A/CDK2-associated p19, Skp2	0	DIRECT
Lactate & malate dehydrogenases, C-terminal domain	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
CAF1-like ribonuclease	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Ribosomal S5 protein, N-terminal domain	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Cofactor-dependent phosphoglycerate mutase	0	DIRECT
SCF ubiquitin ligase complex WHB domain	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
PA domain	0	DIRECT
Ribosomal protein S2	0	DIRECT
COMT-like	0	DIRECT
Molybdenum cofactor-binding domain	0	DIRECT
Ribosomal protein L3	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
Ribosomal protein L39e	0	DIRECT
SAM (sterile alpha motif) domain	0	DIRECT
NLI interacting factor-like phosphatase	0	DIRECT
beta-Phosphoglucomutase-like	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
Alpha subunit of glutamate synthase, C-terminal domain	0	DIRECT
AF1104-like	0	DIRECT
PAZ domain	0	DIRECT
Aminoacid dehydrogenases	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
gamma-carbonic anhydrase-like	0	DIRECT
ATP sulfurylase N-terminal domain	0	DIRECT
SWIRM domain	0	DIRECT
DJ-1/PfpI	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
XPC-binding domain	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
CHY zinc finger	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
D-aminoacid aminotransferase-like PLP-dependent enzymes	0	DIRECT
Sedlin (SEDL)	0	DIRECT
Rhomboid-like	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Glycosyl hydrolases family 32 N-terminal domain	0	DIRECT
monodomain cytochrome c	0	DIRECT
Ribonucleotide reductase-like	0	DIRECT
Chalcone synthase-like	0	DIRECT
glucose-1-phosphate thymidylyltransferase	0	DIRECT
YicI N-terminal domain-like	0	DIRECT
Tim10/DDP	0	DIRECT
Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain	0	DIRECT
Nuclear movement domain	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
Clp protease, ClpP subunit	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Coiled-coil domain of nucleotide exchange factor GrpE	0	DIRECT
Inorganic pyrophosphatase	0	DIRECT
Thioesterases	0	DIRECT
G domain-linked domain	0	DIRECT
HspBP1 domain	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
ATP synthase (F1-ATPase), gamma subunit	0	DIRECT
PsbP-like	0	DIRECT
Ribosomal protein S13	0	DIRECT
Tail specific protease, catalytic domain	0	DIRECT
PaaI/YdiI-like	0	DIRECT
Carbon-carbon bond hydrolase	0	DIRECT
Glycosyl hydrolases family 35 catalytic domain	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Prolyl oligopeptidase, N-terminal domain	0	DIRECT
Ribosomal protein L13	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
Internalin LRR domain	0	DIRECT
2Fe-2S ferredoxin-related	0	DIRECT
Cullin homology domain	0	DIRECT
Ribosomal protein L37e	0	DIRECT
Sigma4 domain	0	DIRECT
Eukaryotic RPB5 N-terminal domain	0	DIRECT
Shikimate kinase (AroK)	0	DIRECT
Predicted hydrolases Cof	0	DIRECT
alpha-mannosidase	0	DIRECT
Clc chloride channel	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
RibA-like	0	DIRECT
BEACH domain	0	DIRECT
Adenosine-5'phosphosulfate kinase (APS kinase)	0	DIRECT
MIF-related	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
FucT-like	0	DIRECT
ATP-dependent protease Lon (La), catalytic domain	0	DIRECT
CAT-like	0	DIRECT
Pyruvate oxidase and decarboxylase, middle domain	0	DIRECT
Smc hinge domain	0	DIRECT
Calcium ATPase, transduction domain A	0	DIRECT
Folylpolyglutamate synthetase	0	DIRECT
Prokaryotic proteases	0	DIRECT
Pyruvate oxidase and decarboxylase Pyr module	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Hermes transposase-like	0	DIRECT
PHL pollen allergen	0	DIRECT
RPB5	0	DIRECT
RraA-like	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Nucleoside diphosphate kinase, NDK	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Carbonic anhydrase	0	DIRECT
CoA-binding domain	0	DIRECT
Formate/glycerate dehydrogenases, substrate-binding domain	0	DIRECT
Tryptophan biosynthesis enzymes	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Linker histone H1/H5	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
Calnexin/calreticulin	0	DIRECT