•  SEARCH

  • Keyword search
  • Sequence search
• 
  

•  BROWSE

  •   Organisms
  • Taxonomy
  • Statistics
  •   SCOP
  • Hierarchy
  •   Ontologies
  • GO
  • EC
  • Phenotype
• 
  

•  TOOLS

  • Compare genomes
  • Phylogenetic trees
  • Web services
  • Downloads
• 
  

•  ABOUT

  • Description
  • Publications
  • Documentation
• 
  

•  HELP

  • User support
  • Contact us
  • Email list
  • Sitemap

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this AP term (Not in SDAP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Signal peptide-binding domain	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
SH3-domain	0	DIRECT
RraA-like	0	DIRECT
DNA repair protein MutS, domain I	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
RNA polymerase subunits	0	DIRECT
Lipocalins	0	DIRECT
LysM domain	0	DIRECT
Granulin repeat	0	DIRECT
Head domain of nucleotide exchange factor GrpE	0	DIRECT
TATA-box binding protein-like	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Phosphofructokinase	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
tRNA-binding arm	0	DIRECT
LeuD/IlvD-like	0	DIRECT
Ribosomal protein L31e	0	DIRECT
Phosphoglycerate kinase	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
Sec7 domain	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
N-terminal, heterodimerisation domain of RBP7 (RpoE)	0	DIRECT
Putative isomerase YbhE	0	DIRECT
YrdC/RibB	0	DIRECT
Tautomerase/MIF	0	DIRECT
L9 N-domain-like	0	DIRECT
V-type ATPase subunit E-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
Ribosomal protein L4	0	DIRECT
Electron transport accessory proteins	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
Single hybrid motif	0	DIRECT
Chelatase	0	DIRECT
FKBP-like	0	DIRECT
PABC (PABP) domain	0	DIRECT
Mitochondrial glycoprotein MAM33-like	0	DIRECT
Clc chloride channel	0	DIRECT
Preprotein translocase SecE subunit	0	DIRECT
DLC	0	DIRECT
Sigma3 and sigma4 domains of RNA polymerase sigma factors	0	DIRECT
Prokaryotic type I DNA topoisomerase	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Pentapeptide repeat-like	0	DIRECT
BolA-like	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
Ribosomal protein L19 (L19e)	0	DIRECT
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0	DIRECT
Saposin	0	DIRECT
Folate-binding domain	0	DIRECT
Peptidyl-tRNA hydrolase-like	0	DIRECT
Expressed protein At2g23090/F21P24.15	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
Ribosomal protein L39e	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
Enolase C-terminal domain-like	0	DIRECT
Hypothetical protein YjiA, C-terminal domain	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
AMPKBI-like	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
Ribosomal protein L13	0	DIRECT
beta-N-acetylhexosaminidase-like domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Chorismate mutase II	0	DIRECT
N-terminal domain of the delta subunit of the F1F0-ATP synthase	0	DIRECT
Ligand-binding domain in the NO signalling and Golgi transport	0	DIRECT
FF domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
GlnB-like	0	DIRECT
Serine metabolism enzymes domain	0	DIRECT
FAH	0	DIRECT
Sigma2 domain of RNA polymerase sigma factors	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
S13-like H2TH domain	0	DIRECT
Ribosomal protein S2	0	DIRECT
Preprotein translocase SecY subunit	0	DIRECT
beta-carbonic anhydrase, cab	0	DIRECT
DNA repair protein MutS, domain II	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Tetrahydrobiopterin biosynthesis enzymes-like	0	DIRECT
Ribosomal protein L16p/L10e	0	DIRECT
ssDNA-binding transcriptional regulator domain	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
LanC-like	0	DIRECT
AlbA-like	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
GroEL apical domain-like	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Flavoproteins	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Cytochrome c	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	DIRECT
Casein kinase II beta subunit	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Enolase N-terminal domain-like	0	DIRECT
eIF1-like	0	DIRECT
Ricin B-like lectins	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
CYTH-like phosphatases	0	DIRECT
Inorganic pyrophosphatase	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
R3H domain	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
Peptide methionine sulfoxide reductase	0	DIRECT
Oxidoreductase molybdopterin-binding domain	0	DIRECT
SMR domain-like	0	DIRECT
Prokaryotic ribosomal protein L17	0	DIRECT
MurD-like peptide ligases, catalytic domain	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
DNA clamp	0	DIRECT
Ribosomal protein S6	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), lid domain	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
Nitrite and sulphite reductase 4Fe-4S domain-like	0	DIRECT
MurD-like peptide ligases, peptide-binding domain	0	DIRECT
Peptidase/esterase 'gauge' domain	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
Ribosomal protein S8	0	DIRECT
Ribosomal protein L29 (L29p)	0	DIRECT
ATP synthase (F1-ATPase), gamma subunit	0	DIRECT
Lipoxigenase	0	DIRECT
SIS domain	0	DIRECT
Ribosomal protein L14	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	0	DIRECT
Alpha subunit of glutamate synthase, C-terminal domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Smc hinge domain	0	DIRECT
ADC-like	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Tim10-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
Nicotinate/Quinolinate PRTase N-terminal domain-like	0	DIRECT
RibA-like	0	DIRECT
Pentein	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
NHL repeat	0	DIRECT
SufE/NifU	0	DIRECT
HesB-like domain	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Coiled-coil domain of nucleotide exchange factor GrpE	0	DIRECT
Dimeric alpha+beta barrel	0	DIRECT
XPC-binding domain	0	DIRECT
Globin-like	0	DIRECT

Family domains annotated to this AP term (SDAP level: Least Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
GroEL-like chaperone, apical domain	0	DIRECT
DNA repair glycosylase, 2 C-terminal domains	0	DIRECT
N-terminal, heterodimerisation domain of RBP7 (RpoE)	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
FF domain	0	DIRECT
Pseudouridine synthase II TruB	0	DIRECT
Heme-dependent catalases	0	DIRECT
AMPKBI-like	0	DIRECT
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0	DIRECT
Plant lipoxigenases	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain	0	DIRECT
Lipoxigenase N-terminal domain	0	DIRECT
DNase I-like	0	DIRECT
Glycerol-3-phosphate dehydrogenase	0	DIRECT
Aminoacid dehydrogenases	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
LIM domain	0	DIRECT
gamma-carbonic anhydrase-like	0	DIRECT
Macro domain	0	DIRECT
Aminomethyltransferase folate-binding domain	0	DIRECT
Sigma4 domain	0	DIRECT
Phosphoenolpyruvate carboxylase	0	DIRECT
LeuD-like	0	DIRECT
Prolyl oligopeptidase, N-terminal domain	0	DIRECT
Allosteric chorismate mutase	0	DIRECT
Tim10/DDP	0	DIRECT
G domain-linked domain	0	DIRECT
ATP synthase (F1-ATPase), gamma subunit	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
RWD domain	0	DIRECT
CoA-binding domain	0	DIRECT
PAPS reductase-like	0	DIRECT
(Glycosyl)asparaginase	0	DIRECT
Spermidine synthase	0	DIRECT
Ribosomal protein L29 (L29p)	0	DIRECT
HMGL-like	0	DIRECT
MPP-like	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Ribosomal protein L4	0	DIRECT
Homoserine dehydrogenase-like	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
HAT/Suf repeat	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB	0	DIRECT
Coiled-coil domain of nucleotide exchange factor GrpE	0	DIRECT
Reductases	0	DIRECT
E2F dimerization segment	0	DIRECT
V-type ATPase subunit E	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Rps19E-like	0	DIRECT
beta-Phosphoglucomutase-like	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
ZZ domain	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
Methionine aminopeptidase, insert domain	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
GABARAP-like	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
Nitrite and sulphite reductase 4Fe-4S domain-like	0	DIRECT
Transcriptional coactivator PC4 C-terminal domain	0	DIRECT
Mitochondrial glycoprotein MAM33-like	0	DIRECT
PDI-like	0	DIRECT
HesB-like domain	0	DIRECT
Swaposin	0	DIRECT
La domain	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), catalytic domain	0	DIRECT
GAF domain	0	DIRECT
PaaI/YdiI-like	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
L23p	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Gtf glycosyltransferase	0	DIRECT
Starch-binding domain	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Ferritin	0	DIRECT
Myf domain	0	DIRECT
FAH	0	DIRECT
Plant stress-induced protein	0	DIRECT
Ribosomal protein S6	0	DIRECT
Ribosomal protein S13	0	DIRECT
AlkB-like	0	DIRECT
Hypothetical protein HI1317	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
DLC	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), lid domain	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
rRNA adenine dimethylase-like	0	DIRECT
SH3-domain	0	DIRECT
LysM domain	0	DIRECT
Glucose 6-phosphate dehydrogenase-like	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
SWIRM domain	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
Subtilase propeptides/inhibitors	0	DIRECT
RNA-polymerase beta-prime	0	DIRECT
R3H domain	0	DIRECT
Cytidylyltransferase	0	DIRECT
HEAT repeat	0	DIRECT
Succinyl-CoA synthetase, beta-chain, N-terminal domain	0	DIRECT
RraA-like	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
Chromo barrel domain	0	DIRECT
B56-like	0	DIRECT
Enolase N-terminal domain-like	0	DIRECT
Ribosomal protein S27e	0	DIRECT
Ribosomal protein L10e	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
BAR domain	0	DIRECT
RibA-like	0	DIRECT
DNA polymerase processivity factor	0	DIRECT
Amylase, catalytic domain	0	DIRECT
Cystatins	0	DIRECT
BolA-like	0	DIRECT
Ribosomal protein S15	0	DIRECT
LON domain-like	0	DIRECT
Rubredoxin	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
ATP sulfurylase N-terminal domain	0	DIRECT
Glutamine synthetase catalytic domain	0	DIRECT
MIF-related	0	DIRECT
Ran-binding domain	0	DIRECT
DNA repair protein MutS, domain I	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Class-II DAHP synthetase	0	DIRECT
beta-N-acetylhexosaminidase catalytic domain	0	DIRECT
Peptidyl-tRNA hydrolase-like	0	DIRECT
Prokaryotic ribosomal protein L17	0	DIRECT
Smr domain	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
SerA intervening domain-like	0	DIRECT
Clc chloride channel	0	DIRECT
Ring hydroxylating alpha subunit ISP domain	0	DIRECT
Receiver domain of the ethylene receptor	0	DIRECT
Sigma2 domain of RNA polymerase sigma factors	0	DIRECT
Ribosomal protein L13	0	DIRECT
Casein kinase II beta subunit	0	DIRECT
Clp protease, ClpP subunit	0	DIRECT
Preprotein translocase SecE subunit	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
Ribosomal protein S8	0	DIRECT
Choline kinase	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
RNB domain-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
5' nucleotidase-like	0	DIRECT
6-phosphogluconate dehydrogenase-like, N-terminal domain	0	DIRECT
Gelsolin-like	0	DIRECT
MYND zinc finger	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
Acyl-ACP thioesterase-like	0	DIRECT
alpha-Amylases, C-terminal beta-sheet domain	0	DIRECT
Oxidoreductase molybdopterin-binding domain	0	DIRECT
alpha-mannosidase	0	DIRECT
Ribosomal protein L14	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
Dihydrodipicolinate reductase-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
Enolase	0	DIRECT
NadC N-terminal domain-like	0	DIRECT
RNase Z-like	0	DIRECT
Cyclin A/CDK2-associated p19, Skp2	0	DIRECT
Adenosine-5'phosphosulfate kinase (APS kinase)	0	DIRECT
Sec7 domain	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
AMPK-beta glycogen binding domain-like	0	DIRECT
Inorganic pyrophosphatase	0	DIRECT
Tail specific protease, catalytic domain	0	DIRECT
Glyoxalase I (lactoylglutathione lyase)	0	DIRECT
Folylpolyglutamate synthetase	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Galactosyltransferase LgtC	0	DIRECT
RelA/SpoT domain	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
GroES	0	DIRECT
Alpha subunit of glutamate synthase, C-terminal domain	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Smc hinge domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
monodomain cytochrome c	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
Peptide methionine sulfoxide reductase	0	DIRECT
GroEL-like chaperone, intermediate domain	0	DIRECT
Granulin repeat	0	DIRECT
LEA14-like	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Gastric lipase	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Cytochrome p450 reductase N-terminal domain-like	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
IPP isomerase-like	0	DIRECT
Thioesterases	0	DIRECT
Prolyl oligopeptidase, C-terminal domain	0	DIRECT
beta-carbonic anhydrase, cab	0	DIRECT
Thiolase-related	0	DIRECT
Shikimate kinase (AroK)	0	DIRECT
Signal peptide-binding domain	0	DIRECT
D-ribulose-5-phosphate 3-epimerase	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Exostosin	0	DIRECT
NadC C-terminal domain-like	0	DIRECT
2Fe-2S ferredoxin-related	0	DIRECT
Sedlin (SEDL)	0	DIRECT
Head domain of nucleotide exchange factor GrpE	0	DIRECT
Ribosomal protein L3	0	DIRECT
Plant transcriptional regulator PBF-2	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Ribosomal protein L19 (L19e)	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Phosphofructokinase	0	DIRECT
NHL repeat	0	DIRECT
CAT-like	0	DIRECT
Anti-sigma factor antagonist SpoIIaa	0	DIRECT
Ribosomal protein L39e	0	DIRECT
Class I aldolase	0	DIRECT
Molybdenum-containing oxidoreductases-like dimerisation domain	0	DIRECT
FucT-like	0	DIRECT
Calnexin/calreticulin	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase dimerisation domain	0	DIRECT
WrbA-like	0	DIRECT
NifU/IscU domain	0	DIRECT
GDI-like N domain	0	DIRECT
GroEL chaperone, ATPase domain	0	DIRECT
Hypothetical protein At2g34160	0	DIRECT
Hypothetical protein YjiA, C-terminal domain	0	DIRECT
BphP N-terminal domain-like	0	DIRECT
eIF1-like	0	DIRECT
STAR domain	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
PhzC/PhzF-like	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Prokaryotic type I DNA topoisomerase	0	DIRECT
ATP sulfurylase catalytic domain	0	DIRECT
Cell cycle arrest protein BUB3	0	DIRECT
PUA domain	0	DIRECT
PCI domain (PINT motif)	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	0	DIRECT
N-acetyl-l-glutamate kinase	0	DIRECT
RhoGDI-like	0	DIRECT
HAL/PAL-like	0	DIRECT
Phytochrome-specific domain	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Ribosomal protein L37e	0	DIRECT
EDF1-like	0	DIRECT
SufE-like	0	DIRECT
Ribosomal protein S2	0	DIRECT
Glyoxalase II (hydroxyacylglutathione hydrolase)	0	DIRECT
TRM1-like	0	DIRECT
Pentapeptide repeats	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
FKBP immunophilin/proline isomerase	0	DIRECT
XPC-binding domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Phosphoglycerate kinase	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Molybdenum cofactor biosynthesis protein MoeB	0	DIRECT
Ribosomal protein L31e	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
Preprotein translocase SecY subunit	0	DIRECT
eIF5a N-terminal domain-like	0	DIRECT
Leukotriene A4 hydrolase catalytic domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
Protein prenyltransferases	0	DIRECT
Sec63 N-terminal domain	0	DIRECT
YicI N-terminal domain-like	0	DIRECT

Trees by TreeVector

A presence/absence matrix is generated using protein domain architecture data for all genomes in SUPERFAMILY. The PAUP software is used to produce a single, large tree topology using heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as if individual trees had been produced. However, this data is extracted from the single large tree. This produces a higher quality topology than if the trees had been produced on their own, and allows the trees to be displayed instantly.

Supra-domains annotated to this AP term (SPAP level: Least Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
FAH	0	DIRECT
Creatinase/aminopeptidase	0	DIRECT
Peptide methionine sulfoxide reductase	0	DIRECT
Ribosomal protein L13	0	DIRECT
6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
Ribosomal protein L16p/L10e	0	DIRECT
Protease propeptides/inhibitors	0	DIRECT
BolA-like	0	DIRECT
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	DIRECT
Lipocalins	0	DIRECT
V-type ATPase subunit E-like	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Electron transport accessory proteins	0	DIRECT
Cation efflux protein transmembrane domain-like	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
Preprotein translocase SecE subunit	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
AlbA-like	0	DIRECT
Expressed protein At2g23090/F21P24.15	0	DIRECT
Mitochondrial glycoprotein MAM33-like	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
LeuD/IlvD-like	0	DIRECT
PABC (PABP) domain	0	DIRECT
FF domain	0	DIRECT
Tautomerase/MIF	0	DIRECT
eIF1-like	0	DIRECT
beta-carbonic anhydrase, cab	0	DIRECT
FKBP-like	0	DIRECT
Ribosomal protein S6	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
Diaminopimelate epimerase-like	0	DIRECT
Smc hinge domain	0	DIRECT
Enolase C-terminal domain-like	0	DIRECT
RNA polymerase subunits	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Magnesium transport protein CorA, transmembrane region	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Alpha subunit of glutamate synthase, C-terminal domain	0	DIRECT
LuxS/MPP-like metallohydrolase	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
Ribosomal protein S2	0	DIRECT
Peptidase/esterase 'gauge' domain	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Nicotinate/Quinolinate PRTase N-terminal domain-like	0	DIRECT
Ribosomal protein L4	0	DIRECT
Preprotein translocase SecY subunit	0	DIRECT
Prokaryotic ribosomal protein L17	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
TATA-box binding protein-like	0	DIRECT
Ribosomal protein L14	0	DIRECT
D-ribose-5-phosphate isomerase (RpiA), lid domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Chorismate mutase II	0	DIRECT
R3H domain	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Phosphoglycerate kinase	0	DIRECT
Tim10-like	0	DIRECT
Casein kinase II beta subunit	0	DIRECT
Lipoxigenase	0	DIRECT
beta-N-acetylhexosaminidase-like domain	0	DIRECT
Sec7 domain	0	DIRECT
XPC-binding domain	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
DLC	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Oxidoreductase molybdopterin-binding domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Sigma2 domain of RNA polymerase sigma factors	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
Tetrapyrrole methylase	0	DIRECT
SufE/NifU	0	DIRECT
Peptidyl-tRNA hydrolase-like	0	DIRECT
N-terminal domain of the delta subunit of the F1F0-ATP synthase	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Saposin	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
RibA-like	0	DIRECT
NHL repeat	0	DIRECT
Hypothetical protein YjiA, C-terminal domain	0	DIRECT
DNA repair protein MutS, domain I	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
Tetrahydrobiopterin biosynthesis enzymes-like	0	DIRECT
Cytochrome c	0	DIRECT
ATP synthase (F1-ATPase), gamma subunit	0	DIRECT
DNA repair protein MutS, domain II	0	DIRECT
YrdC/RibB	0	DIRECT
L9 N-domain-like	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
CYTH-like phosphatases	0	DIRECT
Sigma3 and sigma4 domains of RNA polymerase sigma factors	0	DIRECT
Folate-binding domain	0	DIRECT
Inorganic pyrophosphatase	0	DIRECT
C-terminal autoproteolytic domain of nucleoporin nup98	0	DIRECT
Cryptochrome/photolyase FAD-binding domain	0	DIRECT
MurD-like peptide ligases, catalytic domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
alpha-helical ferredoxin	0	DIRECT
Enolase N-terminal domain-like	0	DIRECT
Ribosomal protein L31e	0	DIRECT
SMR domain-like	0	DIRECT
Single hybrid motif	0	DIRECT
Ribosomal protein L19 (L19e)	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Heme-dependent catalase-like	0	DIRECT
Prokaryotic type I DNA topoisomerase	0	DIRECT
GroEL apical domain-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
Clc chloride channel	0	DIRECT
GlnB-like	0	DIRECT
MurD-like peptide ligases, peptide-binding domain	0	DIRECT
ADC-like	0	DIRECT
Dimeric alpha+beta barrel	0	DIRECT
Chelatase	0	DIRECT
Pentapeptide repeat-like	0	DIRECT
Glutamine synthetase, N-terminal domain	0	DIRECT
LysM domain	0	DIRECT
HesB-like domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Putative isomerase YbhE	0	DIRECT
Ligand-binding domain in the NO signalling and Golgi transport	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Phosphofructokinase	0	DIRECT
Ricin B-like lectins	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Ribosomal L11/L12e N-terminal domain	0	DIRECT
Head domain of nucleotide exchange factor GrpE	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0	DIRECT
Nitrite and sulphite reductase 4Fe-4S domain-like	0	DIRECT
AMPKBI-like	0	DIRECT
ssDNA-binding transcriptional regulator domain	0	DIRECT
Glycolipid transfer protein, GLTP	0	DIRECT
DNA clamp	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
S13-like H2TH domain	0	DIRECT
Cation efflux protein cytoplasmic domain-like	0	DIRECT
Glycerol-3-phosphate (1)-acyltransferase	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
RuBisCo LSMT C-terminal, substrate-binding domain	0	DIRECT
Flavoproteins	0	DIRECT
Ribosomal protein L39e	0	DIRECT
Globin-like	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
Coiled-coil domain of nucleotide exchange factor GrpE	0	DIRECT
Granulin repeat	0	DIRECT
tRNA-binding arm	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
SH3-domain	0	DIRECT
Ribosomal protein L29 (L29p)	0	DIRECT
N-terminal, heterodimerisation domain of RBP7 (RpoE)	0	DIRECT
Signal peptide-binding domain	0	DIRECT
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	0	DIRECT
Serine metabolism enzymes domain	0	DIRECT
Pentein	0	DIRECT
Ribosomal protein S8	0	DIRECT
SIS domain	0	DIRECT
LanC-like	0	DIRECT
RraA-like	0	DIRECT
Aldolase	0.0007976	DIRECT