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Disease Ontology (DO): disease of metabolism

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   disease [DOID:4] <8>
0:   disease of metabolism [DOID:0014667] <2>(22|34) (27|12|5)
- 1:   inherited metabolic disorder [DOID:655] <18>(12|15) (16|5|0)
- 1:   acquired metabolic disease [DOID:0060158] <8>(14|21) (16|10|5)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Homocysteine S-methyltransferase0Direct
Fibrinogen coiled-coil and central regions0Direct
Calpain large subunit, middle domain (domain III)0Direct
Rudiment single hybrid motif0Direct
Apolipoprotein A-I0Direct
Nuclear receptor ligand-binding domain0.0000001462Direct
(Trans)glycosidases0.0000001599Direct
MHC antigen-recognition domain0.000001342Direct
FabD/lysophospholipase-like0.00003324Direct
Single hybrid motif0.0001052Direct
Glycosyl hydrolase domain0.0003507Direct
4-helical cytokines0.0003746Direct
Insulin-like0.000448Direct
Flavoproteins0.001967Inherited
Alkaline phosphatase-like0.003176Inherited
MFS general substrate transporter0.004583Inherited
TNF-like0.005612Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.03018Inherited
Family A G protein-coupled receptor-like0.03056Inherited
PGBD-like0.07032Inherited
Voltage-gated potassium channels0.745Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
BC C-terminal domain-like0Direct
AAT-like0Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
Multidomain cupredoxins0Direct
Calpain large subunit, middle domain (domain III)0Direct
Homocysteine S-methyltransferase0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Apolipoprotein A-I0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Nuclear receptor ligand-binding domain0.0000001475Direct
C1 set domains (antibody constant domain-like)0.0000001644Direct
Nuclear receptor0.000000237Direct
MHC antigen-recognition domain0.000001213Direct
Amylase, catalytic domain0.00007877Direct
Biotinyl/lipoyl-carrier proteins and domains0.00007877Direct
L domain0.0003298Direct
Insulin-like0.0003298Direct
Long-chain cytokines0.000911Direct
BC ATP-binding domain-like0.001386Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001386Inherited
BC N-terminal domain-like0.001386Inherited
NADPH-cytochrome p450 reductase-like0.001386Inherited
TNF-like0.004826Inherited
beta-glycanases0.00547Inherited
Arylsulfatase0.005581Inherited
Rhodopsin-like0.02022Inherited
Interleukin-1 (IL-1)0.02335Inherited
UDPGT-like0.02335Inherited
Fatty acid binding protein-like0.03742Inherited
MMP N-terminal domain0.06233Inherited
Matrix metalloproteases, catalytic domain0.1238Inherited
Hemopexin-like domain0.1494Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Rudiment single hybrid motif0Direct
Fibrinogen coiled-coil and central regions0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Apolipoprotein A-I0Direct
Homocysteine S-methyltransferase0Direct
Calpain large subunit, middle domain (domain III)0Direct
Nuclear receptor ligand-binding domain0.00000007265Direct
(Trans)glycosidases0.00000007963Direct
MHC antigen-recognition domain0.0000006958Direct
FabD/lysophospholipase-like0.00001898Direct
Single hybrid motif0.00006185Direct
Glycosyl hydrolase domain0.0002126Direct
4-helical cytokines0.0002272Direct
Insulin-like0.0002736Direct
Flavoproteins0.001276Inherited
Alkaline phosphatase-like0.002108Inherited
MFS general substrate transporter0.003096Inherited
TNF-like0.00383Inherited
Lipocalins0.01061Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.02238Inherited
Family A G protein-coupled receptor-like0.02271Inherited
Kringle-like0.02975Inherited
PGBD-like0.05463Inherited
Cytokine0.06067Inherited
Hemopexin-like domain0.1328Inherited
Complement control module/SCR domain0.4503Inherited
Voltage-gated potassium channels0.6728Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00000005458Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00004124Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00008034Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.0002126Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0002736Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0002736Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.05463Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3367Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0002736Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.004631Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.004631Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3628Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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