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Disease Ontology (DO): disease of cellular proliferation

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   disease [DOID:4] <8>
0:   disease of cellular proliferation [DOID:14566] <3>(123|191) (129|118|56)
- 1:   pre-malignant neoplasm [DOID:0060071] <4>(4|5) (4|4|3)
- 1:   benign neoplasm [DOID:0060072] <2>(14|21) (16|14|9)
- 1:   cancer [DOID:162] <2>(115|181) (120|113|54)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
PLC-like phosphodiesterases0Direct
NAD(P)-linked oxidoreductase0Direct
BTG domain-like0Direct
GroES-like0Direct
Acid proteases0Direct
DNA polymerase beta, N-terminal domain-like0Direct
Apolipoprotein A-I0Direct
p53 tetramerization domain0Direct
Di-copper centre-containing domain0Direct
Plakin repeat0Direct
ACP-like0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
Saposin0Direct
DNA-glycosylase0Direct
Triple coiled coil domain of C-type lectins0Direct
Proteasome activator0Direct
Metallothionein0Direct
HIT-like0Direct
Phosphoglycerate mutase-like0Direct
Synuclein0Direct
Nuclear receptor coactivator interlocking domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
BAG domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
PLP-binding barrel0Direct
SMAD MH1 domain0Direct
Serum albumin-like0Direct
DNA clamp0Direct
CCHHC domain0Direct
Aconitase iron-sulfur domain0Direct
LeuD/IlvD-like0Direct
post-AAA+ oligomerization domain-like0Direct
Orange domain-like0Direct
Rap/Ran-GAP0Direct
Sialidases0Direct
HSP90 C-terminal domain0Direct
Restriction endonuclease-like0Direct
Integrin beta tail domain0Direct
Calpain large subunit, middle domain (domain III)0Direct
Transferrin receptor-like dimerisation domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
TAFH domain-like0Direct
PP2C-like0Direct
Insulin-like0Direct
Zn-binding ribosomal proteins0Direct
Alanine racemase C-terminal domain-like0Direct
SPOC domain-like0Direct
PAZ domain0Direct
Retrovirus capsid dimerization domain-like0Direct
Annexin0Direct
Uracil-DNA glycosylase-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Purine and uridine phosphorylases0Direct
FAD-dependent thiol oxidase0Direct
Flavoproteins0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
alpha-ketoacid dehydrogenase kinase, N-terminal domain0Direct
G protein-binding domain0Direct
Polo-box domain0Direct
SRF-like0Direct
FAS1 domain0Direct
Serine protease inhibitors0Direct
Uteroglobin-like0Direct
14-3-3 protein0Direct
Nuclear receptor ligand-binding domain0.00002519Direct
Protein kinase-like (PK-like)0.00005551Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0006067Direct
SH2 domain0.001154Inherited
Integrin domains0.002616Inherited
Cystine-knot cytokines0.00874Inherited
PGBD-like0.008817Inherited
Leucine zipper domain0.008986Inherited
Ubiquitin-like0.009963Inherited
TIMP-like0.01195Inherited
SAM/Pointed domain0.01567Inherited
Growth factor receptor domain0.01772Inherited
HMG-box0.01814Inherited
HLH, helix-loop-helix DNA-binding domain0.01819Inherited
Caspase-like0.02123Inherited
Arginase/deacetylase0.02123Inherited
Cyclin-like0.02294Inherited
4-helical cytokines0.03709Inherited
Bcl-2 inhibitors of programmed cell death0.03819Inherited
Frizzled cysteine-rich domain0.04612Inherited
TNF receptor-like0.04617Inherited
Snake toxin-like0.05805Inherited
FnI-like domain0.05805Inherited
Hemopexin-like domain0.05805Inherited
Thyroglobulin type-1 domain0.05934Inherited
SOCS box-like0.06789Inherited
Metalloproteases ("zincins"), catalytic domain0.06859Inherited
Ran binding protein zinc finger-like0.09692Inherited
Blood coagulation inhibitor (disintegrin)0.1237Inherited
Galactose-binding domain-like0.1591Inherited
Lipoxigenase0.214Inherited
Immunoglobulin0.2343Inherited
Kringle-like0.2426Inherited
Notch domain0.2812Inherited
Toll/Interleukin receptor TIR domain0.2817Inherited
A DNA-binding domain in eukaryotic transcription factors0.3034Inherited
Thioredoxin-like0.3207Inherited
Nucleotide-diphospho-sugar transferases0.3367Inherited
p53-like transcription factors0.3367Inherited
Defensin-like0.3729Inherited
Heme-dependent peroxidases0.3729Inherited
Globin-like0.4284Inherited
Prefoldin0.4328Inherited
Ankyrin repeat0.4422Inherited
Second domain of FERM0.4465Inherited
STAT0.4573Inherited
Transcription factor STAT-4 N-domain0.4573Inherited
TSP-1 type 1 repeat0.4894Inherited
MHC antigen-recognition domain0.5085Inherited
Interleukin 8-like chemokines0.5532Inherited
ABC transporter transmembrane region0.6528Inherited
DNA repair protein MutS, domain III0.6652Inherited
TNF-like0.7108Inherited
Family A G protein-coupled receptor-like0.7417Inherited
DPP6 N-terminal domain-like0.8375Inherited
alpha/beta-Hydrolases0.8839Inherited
Intermediate filament protein, coiled coil region0.9856Inherited
SNARE fusion complex1Inherited
HD-domain/PDEase-like1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
AlkB-like0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Integrin beta tail domain0Direct
14-3-3 protein0Direct
CCHHC domain0Direct
Apolipoprotein A-I0Direct
Calpain large subunit, middle domain (domain III)0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
HSP90 C-terminal domain0Direct
Hairy Orange domain0Direct
5' to 3' exonuclease catalytic domain0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
L30e/L7ae ribosomal proteins0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
Prokaryotic proteases0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
SMAD MH1 domain0Direct
CAD domain0Direct
alpha-ketoacid dehydrogenase kinase, N-terminal domain0Direct
Short-chain cytokines0Direct
FolH catalytic domain-like0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0Direct
DNA gyrase/MutL, second domain0Direct
MIF4G domain-like0Direct
Chromo barrel domain0Direct
Hsp90 middle domain0Direct
Sialidases (neuraminidases)0Direct
Ras-binding domain, RBD0Direct
FAD-dependent thiol oxidase0Direct
DNA polymerase beta, N-terminal domain-like0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
DEATH effector domain, DED0Direct
Pepsin-like0Direct
Proprotein convertase P-domain0Direct
STAR domain0Direct
GABARAP-like0Direct
Neurotrophin0Direct
ZZ domain0Direct
Arginase-like amidino hydrolases0Direct
Alkaline phosphatase0Direct
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain0Direct
Methyl-CpG-binding domain, MBD0Direct
Aldo-keto reductases (NADP)0Direct
Epoxide hydrolase0Direct
Transferrin receptor-like dimerisation domain0Direct
Integrin beta EGF-like domains0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
PP2C-like0Direct
BTG domain-like0Direct
Adenain-like0Direct
Extracellular domain of cell surface receptors0Direct
NADPH-cytochrome p450 reductase-like0Direct
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain0Direct
Pointed domain0Direct
Uteroglobin-like0Direct
alpha-ketoacid dehydrogenase kinase, C-terminal domain0Direct
Tissue inhibitor of metalloproteinases, TIMP0Direct
MutT-like0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
SMAD domain0Direct
Insulin-like0Direct
TAFH domain-like0Direct
BAG domain0Direct
POU-specific domain0Direct
HtrA-like serine proteases0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Alanine racemase-like, N-terminal domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
DIX domain0Direct
Platelet-derived growth factor-like0Direct
Arginine methyltransferase0Direct
Rap/Ran-GAP0Direct
DNA polymerase III clamp loader subunits, C-terminal domain0Direct
Purine and uridine phosphorylases0Direct
Plakin repeat0Direct
BAFF receptor-like0Direct
Ephrin receptor ligand binding domain0Direct
Annexin0Direct
Gelsolin-like0Direct
Erythroid transcription factor GATA-10Direct
DNA polymerase beta-like0Direct
L domain0Direct
Synuclein0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
Triple coiled coil domain of C-type lectins0Direct
PAZ domain0Direct
PA domain0Direct
Fatty acid binding protein-like0Direct
Proteasome activator0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
Nuclear receptor coactivator interlocking domain0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
FAS1 domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
LeuD-like0Direct
Transferrin0Direct
Multidomain cupredoxins0Direct
SRF-like0Direct
Mammalian PLC0Direct
XPF/Rad1/Mus81 nuclease0Direct
Prohormone convertase 1 pro-domain0Direct
Aconitase iron-sulfur domain0Direct
Polo-box duplicated region0Direct
C2 set domains0Direct
UDPGT-like0Direct
DNA ligase0Direct
SCAN domain0Direct
Bee venom hyaluronidase0Direct
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain0Direct
Cystatins0Direct
Eukaryotic ODC-like0Direct
Serum albumin-like0Direct
Retinoblastoma tumor suppressor domains0Direct
Metallothionein0Direct
Ricin B-like0Direct
Nuclear receptor ligand-binding domain0.00002035Direct
Nuclear receptor0.00003882Direct
Protein kinases, catalytic subunit0.00006145Direct
SH2 domain0.001009Inherited
Growth factor receptor domain0.001129Inherited
Integrin domains0.001986Inherited
Matrix metalloproteases, catalytic domain0.002715Inherited
MMP N-terminal domain0.00679Inherited
Transforming growth factor (TGF)-beta0.007064Inherited
Leucine zipper domain0.007403Inherited
HMG-box0.01497Inherited
HLH, helix-loop-helix DNA-binding domain0.01633Inherited
Cyclin0.02961Inherited
Caspase catalytic domain0.03093Inherited
S100 proteins0.03093Inherited
Bcl-2 inhibitors of programmed cell death0.03093Inherited
Frizzled cysteine-rich domain0.03863Inherited
Long-chain cytokines0.0417Inherited
Histone deacetylase, HDAC0.0417Inherited
Hemopexin-like domain0.04943Inherited
Thyroglobulin type-1 domain0.04998Inherited
SOCS box-like0.05666Inherited
SAM (sterile alpha motif) domain0.06174Inherited
Paired domain0.07623Inherited
TNF receptor-like0.07805Inherited
Ran binding protein zinc finger-like0.08274Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1067Inherited
Blood coagulation inhibitor (disintegrin)0.1067Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.1356Inherited
Ephrin ectodomain0.1382Inherited
PB1 domain0.1382Inherited
ABC transporter transmembrane region0.1561Inherited
First domain of FERM0.1858Inherited
Animal lipoxigenases0.1877Inherited
I set domains0.1979Inherited
Fibronectin type II module0.2193Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.2193Inherited
EGF-type module0.2228Inherited
FHA domain0.2268Inherited
Lipoxigenase N-terminal domain0.2505Inherited
Notch domain0.2505Inherited
A DNA-binding domain in eukaryotic transcription factors0.2756Inherited
Glutathione peroxidase-like0.2758Inherited
Toll/Interleukin receptor TIR domain0.3053Inherited
C1 set domains (antibody constant domain-like)0.3364Inherited
Nucleoside diphosphate kinase, NDK0.3364Inherited
Hexokinase0.3364Inherited
Defensin0.3427Inherited
Myeloperoxidase-like0.3427Inherited
Second domain of FERM0.357Inherited
Globins0.3992Inherited
STAT DNA-binding domain0.4256Inherited
Transcription factor STAT-4 N-domain0.4256Inherited
STAT0.4256Inherited
Ankyrin repeat0.4274Inherited
Third domain of FERM0.4323Inherited
Kringle modules0.4367Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4425Inherited
TSP-1 type 1 repeat0.4715Inherited
MHC antigen-recognition domain0.4878Inherited
DPP6 N-terminal domain-like0.5187Inherited
Interleukin 8-like chemokines0.5353Inherited
Eukaryotic proteases0.5459Inherited
Reprolysin-like0.5752Inherited
DPP6 catalytic domain-like0.6299Inherited
DNA repair protein MutS, domain III0.6299Inherited
TNF-like0.6892Inherited
Rhodopsin-like0.7973Inherited
Interleukin-1 (IL-1)0.883Inherited
ABC transporter ATPase domain-like0.9011Inherited
PDEase0.9015Inherited
Intermediate filament protein, coiled coil region0.9732Inherited
SNARE fusion complex1Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Flavoproteins0Direct
DNA clamp0Direct
Uteroglobin-like0Direct
Nuclear receptor coactivator interlocking domain0Direct
Sialidases0Direct
Alanine racemase C-terminal domain-like0Direct
Transferrin receptor-like dimerisation domain0Direct
Proteasome activator0Direct
DNA-glycosylase0Direct
SMAD MH1 domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
post-AAA+ oligomerization domain-like0Direct
14-3-3 protein0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Rap/Ran-GAP0Direct
Serine protease inhibitors0Direct
DNA polymerase beta, N-terminal domain-like0Direct
Di-copper centre-containing domain0Direct
Plakin repeat0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
GroES-like0Direct
Apolipoprotein A-I0Direct
HSP90 C-terminal domain0Direct
HIT-like0Direct
NAD(P)-linked oxidoreductase0Direct
Serum albumin-like0Direct
Retrovirus capsid dimerization domain-like0Direct
CCHHC domain0Direct
Orange domain-like0Direct
ACP-like0Direct
Uracil-DNA glycosylase-like0Direct
Calpain large subunit, middle domain (domain III)0Direct
Metallothionein0Direct
Synuclein0Direct
PLP-binding barrel0Direct
Phosphoglycerate mutase-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Triple coiled coil domain of C-type lectins0Direct
G protein-binding domain0Direct
FAD-dependent thiol oxidase0Direct
BAG domain0Direct
p53 tetramerization domain0Direct
PLC-like phosphodiesterases0Direct
alpha-ketoacid dehydrogenase kinase, N-terminal domain0Direct
FAS1 domain0Direct
Annexin0Direct
PAZ domain0Direct
SPOC domain-like0Direct
Purine and uridine phosphorylases0Direct
Polo-box domain0Direct
TAFH domain-like0Direct
Saposin0Direct
SRF-like0Direct
PP2C-like0Direct
BTG domain-like0Direct
Restriction endonuclease-like0Direct
Aconitase iron-sulfur domain0Direct
Insulin-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
LeuD/IlvD-like0Direct
Acid proteases0Direct
Integrin beta tail domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
Zn-binding ribosomal proteins0Direct
Nuclear receptor ligand-binding domain0.00001428Direct
Protein kinase-like (PK-like)0.00003208Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0003726Direct
SH2 domain0.0007314Direct
Integrin domains0.001723Inherited
Cystine-knot cytokines0.006017Inherited
PGBD-like0.006077Inherited
Leucine zipper domain0.00621Inherited
Ubiquitin-like0.00694Inherited
TIMP-like0.008392Inherited
SAM/Pointed domain0.01113Inherited
Growth factor receptor domain0.01273Inherited
HMG-box0.01303Inherited
HLH, helix-loop-helix DNA-binding domain0.01308Inherited
Arginase/deacetylase0.01541Inherited
Caspase-like0.01541Inherited
Cyclin-like0.01674Inherited
4-helical cytokines0.02773Inherited
Bcl-2 inhibitors of programmed cell death0.02859Inherited
Frizzled cysteine-rich domain0.03501Inherited
TNF receptor-like0.03504Inherited
Snake toxin-like0.04455Inherited
Hemopexin-like domain0.04455Inherited
FnI-like domain0.04455Inherited
Thyroglobulin type-1 domain0.04562Inherited
SOCS box-like0.0526Inherited
Metalloproteases ("zincins"), catalytic domain0.05316Inherited
BRCT domain0.05639Inherited
Ran binding protein zinc finger-like0.0769Inherited
Blood coagulation inhibitor (disintegrin)0.09919Inherited
Galactose-binding domain-like0.1292Inherited
Lipoxigenase0.1775Inherited
Immunoglobulin0.1954Inherited
Kringle-like0.2028Inherited
Putative DNA-binding domain0.2379Inherited
Notch domain0.2379Inherited
Toll/Interleukin receptor TIR domain0.2384Inherited
A DNA-binding domain in eukaryotic transcription factors0.2585Inherited
Thioredoxin-like0.2744Inherited
p53-like transcription factors0.2893Inherited
Nucleotide-diphospho-sugar transferases0.2893Inherited
Defensin-like0.3212Inherited
Heme-dependent peroxidases0.3212Inherited
Globin-like0.3725Inherited
Prefoldin0.3763Inherited
Ankyrin repeat0.3849Inherited
Second domain of FERM0.3891Inherited
Transcription factor STAT-4 N-domain0.3988Inherited
STAT0.3988Inherited
TSP-1 type 1 repeat0.4296Inherited
MHC antigen-recognition domain0.4475Inherited
Interleukin 8-like chemokines0.4902Inherited
Trypsin-like serine proteases0.53Inherited
ABC transporter transmembrane region0.5829Inherited
Nucleoside diphosphate kinase, NDK0.5943Inherited
DNA repair protein MutS, domain III0.5943Inherited
TNF-like0.639Inherited
Family A G protein-coupled receptor-like0.6699Inherited
Cytokine0.6848Inherited
EF-hand0.7331Inherited
DPP6 N-terminal domain-like0.7651Inherited
alpha/beta-Hydrolases0.812Inherited
Intermediate filament protein, coiled coil region0.9184Inherited
HD-domain/PDEase-like0.9611Inherited
SNARE fusion complex0.9988Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    57903,63748
  • 57903 - FYVE/PHD zinc finger
  • 63748 - Tudor/PWWP/MBT
  • 0Direct
    53448,50370
  • 53448 - Nucleotide-diphospho-sugar transferases
  • 50370 - Ricin B-like lectins
  • 0Direct
    63748,82199
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 0Direct
    50494,50156
  • 50494 - Trypsin-like serine proteases
  • 50156 - PDZ domain-like
  • 0Direct
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    56436,57535
  • 56436 - C-type lectin-like
  • 57535 - Complement control module/SCR domain
  • 0Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    69012,55874
  • 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 0Direct
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0Direct
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57889,49562
  • 57889 - Cysteine-rich domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0Direct
    52025,53187
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    46938,52087
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    57184,100895
  • 57184 - Growth factor receptor domain
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    53850,53850
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0Direct
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0Direct
    51045,56204
  • 51045 - WW domain
  • 56204 - Hect, E3 ligase catalytic domain
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    100895,47473
  • 100895 - Kazal-type serine protease inhibitors
  • 47473 - EF-hand
  • 0Direct
    55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0Direct
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    54403,54403
  • 54403 - Cystatin/monellin
  • 54403 - Cystatin/monellin
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    53187,47672
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    53732,52016
  • 53732 - Aconitase iron-sulfur domain
  • 52016 - LeuD/IlvD-like
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    50729,57863
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 0Direct
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0Direct
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0Direct
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    54236,50729
  • 54236 - Ubiquitin-like
  • 50729 - PH domain-like
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    51419,50621
  • 51419 - PLP-binding barrel
  • 50621 - Alanine racemase C-terminal domain-like
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    55550,50729
  • 55550 - SH2 domain
  • 50729 - PH domain-like
  • 0Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    52540,53254
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 53254 - Phosphoglycerate mutase-like
  • 0Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    48726,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 0Direct
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    82199,57903
  • 82199 - SET domain
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57302,57302
  • 57302 - Snake toxin-like
  • 57302 - Snake toxin-like
  • 0Direct
    50044,56112
  • 50044 - SH3-domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    82199,57667
  • 82199 - SET domain
  • 57667 - beta-beta-alpha zinc fingers
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.001639Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.006077Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.008392Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.02681Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.04562Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0719Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0719Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.09721Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.09919Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1016Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1297Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.1312Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.1775Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.1775Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.1775Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.2056Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.2585Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.2805Inherited
    103575,81296
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 0.3182Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.3212Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3643Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.3988Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.3988Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.3988Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.4177Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.4334Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.4422Inherited
    82171,53474
  • 82171 - DPP6 N-terminal domain-like
  • 53474 - alpha/beta-Hydrolases
  • 0.4909Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.5759Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.5829Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.5943Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    48552,48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0Direct
    48726,56436,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    54791,54791,54791
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 0Direct
    51045,51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 51045 - WW domain
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    47473,51695,49562
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    57903,63748,82199
  • 57903 - FYVE/PHD zinc finger
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 0Direct
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    53067,53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    55753,55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    57889,57889,49562
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    82199,57667,57667
  • 82199 - SET domain
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    52025,53187,47672
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    48726,49265,56112
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    63748,82199,57903
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    51045,51045,56204
  • 51045 - WW domain
  • 51045 - WW domain
  • 56204 - Hect, E3 ligase catalytic domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.01541Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0719Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.08338Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.2805Inherited
    103575,81296,81296
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.3182Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.3461Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.3988Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.3988Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.5218Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6248Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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