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Disease Ontology (DO): hypersensitivity reaction disease

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   disease [DOID:4] <8>
+ + 2:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ 1:   immune system disease [DOID:2914] <4>(39|47) (42|27|16)
0:   hypersensitivity reaction disease [DOID:0060056] <5>(35|46) (37|23|14)
- 1:   hypersensitivity reaction type II disease [DOID:417] <26>(33|43) (35|23|14)
- 1:   hypersensitivity reaction type IV disease [DOID:2916] <7>(5|4) (5|1|0)
- 1:   allergic hypersensitivity disease [DOID:1205] <6>(0|0) (0|1|0)
- 1:   hypersensitivity reaction type III disease [DOID:1557] <2>(0|0) (0|0|0)
- 1:   immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome [DOID:0090110](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Di-copper centre-containing domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Toll/Interleukin receptor TIR domain0.0001191Direct
Notch domain0.000326Direct
ABC transporter transmembrane region0.0004659Direct
Integrin beta tail domain0.001355Inherited
STAT0.003354Inherited
Transcription factor STAT-4 N-domain0.003354Inherited
Calcium-dependent phosphotriesterase0.006404Inherited
Transglutaminase, two C-terminal domains0.006713Inherited
Bcl-2 inhibitors of programmed cell death0.008688Inherited
Single hybrid motif0.0237Inherited
SMAD MH1 domain0.0237Inherited
Growth factor receptor domain0.0273Inherited
RNI-like0.02788Inherited
CoA-dependent acyltransferases0.03732Inherited
4-helical cytokines0.04666Inherited
EGF/Laminin0.04709Inherited
Immunoglobulin0.05838Inherited
Interleukin 8-like chemokines0.1331Inherited
MHC antigen-recognition domain0.1331Inherited
TNF-like0.1512Inherited
TNF receptor-like0.1957Inherited
DEATH domain0.3115Inherited
vWA-like0.3219Inherited
Cysteine proteinases0.3646Inherited
Complement control module/SCR domain0.4508Inherited
PGBD-like0.4667Inherited
Cytokine0.4667Inherited
E set domains0.5176Inherited
Plexin repeat0.5283Inherited
Anaphylotoxins (complement system)0.6764Inherited
Integrin domains0.6841Inherited
Hemopexin-like domain0.79Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Serum paraoxonase/arylesterase 1, PON10Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Interferons/interleukin-10 (IL-10)0.000000433Direct
ABC transporter transmembrane region0.00006276Direct
Toll/Interleukin receptor TIR domain0.00006276Direct
V set domains (antibody variable domain-like)0.0001828Direct
Notch domain0.0002488Direct
Interleukin-1 (IL-1)0.0005953Direct
Integrin beta tail domain0.001044Inherited
Integrin beta EGF-like domains0.001044Inherited
C2 set domains0.001361Inherited
Cytochrome p450 reductase N-terminal domain-like0.001471Inherited
STAT DNA-binding domain0.002673Inherited
Transcription factor STAT-4 N-domain0.002673Inherited
STAT0.002673Inherited
Long-chain cytokines0.004594Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.005016Inherited
Pentraxin (pentaxin)0.005016Inherited
NADPH-cytochrome p450 reductase-like0.005016Inherited
Transglutaminase N-terminal domain0.005405Inherited
Transglutaminase, two C-terminal domains0.005405Inherited
Bcl-2 inhibitors of programmed cell death0.007234Inherited
Transglutaminase core0.009594Inherited
Growth factor receptor domain0.01341Inherited
SMAD MH1 domain0.01986Inherited
SMAD domain0.01986Inherited
Biotinyl/lipoyl-carrier proteins and domains0.01986Inherited
EGF-type module0.05037Inherited
Interleukin 8-like chemokines0.1194Inherited
MHC antigen-recognition domain0.1194Inherited
I set domains0.1353Inherited
TNF-like0.1361Inherited
TNF receptor-like0.2306Inherited
Short-chain cytokines0.3007Inherited
C1 set domains (antibody constant domain-like)0.3253Inherited
Integrin A (or I) domain0.3874Inherited
Complement control module/SCR domain0.4321Inherited
MMP N-terminal domain0.4405Inherited
Plexin repeat0.5003Inherited
Platelet-derived growth factor-like0.6459Inherited
Anaphylotoxins (complement system)0.6459Inherited
Netrin-like domain (NTR/C345C module)0.6459Inherited
Integrin domains0.6605Inherited
Hemopexin-like domain0.7679Inherited
Matrix metalloproteases, catalytic domain0.7679Inherited
Ankyrin repeat0.9098Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Di-copper centre-containing domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Toll/Interleukin receptor TIR domain0.00007049Direct
Notch domain0.0001974Direct
ABC transporter transmembrane region0.000285Direct
Integrin beta tail domain0.0008621Direct
Snake toxin-like0.001997Inherited
Transcription factor STAT-4 N-domain0.002233Inherited
STAT0.002233Inherited
Calcium-dependent phosphotriesterase0.004388Inherited
Transglutaminase, two C-terminal domains0.004607Inherited
Bcl-2 inhibitors of programmed cell death0.005976Inherited
SMAD MH1 domain0.01734Inherited
Single hybrid motif0.01734Inherited
Growth factor receptor domain0.0201Inherited
RNI-like0.02058Inherited
CoA-dependent acyltransferases0.0279Inherited
4-helical cytokines0.03538Inherited
EGF/Laminin0.03571Inherited
Immunoglobulin0.04479Inherited
Interleukin 8-like chemokines0.1073Inherited
MHC antigen-recognition domain0.1073Inherited
TNF-like0.1224Inherited
TNF receptor-like0.1612Inherited
DEATH domain0.2658Inherited
vWA-like0.2755Inherited
Cysteine proteinases0.3138Inherited
Complement control module/SCR domain0.3928Inherited
Cytokine0.4081Inherited
PGBD-like0.4081Inherited
E set domains0.4564Inherited
Plexin repeat0.4662Inherited
Anaphylotoxins (complement system)0.6053Inherited
Integrin domains0.6133Inherited
Hemopexin-like domain0.7179Inherited
Ankyrin repeat0.8534Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00000007386Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000285Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0008621Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.002233Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.002233Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.002233Inherited
    54001,49309
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.004607Inherited
    81296,54001
  • 81296 - E set domains
  • 54001 - Cysteine proteinases
  • 0.004607Inherited
    49309,49309
  • 49309 - Transglutaminase, two C-terminal domains
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.004607Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.01511Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.02558Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.03092Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03421Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1224Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.2105Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2105Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.4081Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.4662Inherited
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0.6053Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00003049Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00003049Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0001974Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0008621Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.001098Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.002233Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.002233Inherited
    81296,54001,49309
  • 81296 - E set domains
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.004607Inherited
    54001,49309,49309
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.004607Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.01783Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02459Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.2755Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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