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Disease Ontology (DO): immune system cancer

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   disease [DOID:4] <8>
+ + + 3:   disease of cellular proliferation [DOID:14566] <3>(123|191) (129|118|56)
+ + 2:   cancer [DOID:162] <2>(115|181) (120|113|54)
+ 1:   organ system cancer [DOID:0050686] <14>(66|106) (72|58|31)
0:   immune system cancer [DOID:0060083] <3>(31|42) (33|27|13)
- 1:   hematologic cancer [DOID:2531] <7>(30|42) (32|25|13)
- 1:   lymphatic system cancer [DOID:0060073] <5>(0|0) (0|0|0)
- 1:   thymus cancer [DOID:3277] <3>(1|1) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
TAFH domain-like0Direct
Immunoglobulin0.0000001502Direct
TNF receptor-like0.00009548Direct
Inhibitor of apoptosis (IAP) repeat0.0001317Direct
A DNA-binding domain in eukaryotic transcription factors0.0001746Direct
4-helical cytokines0.0005893Direct
SH2 domain0.004618Inherited
p53-like transcription factors0.005552Inherited
Defensin-like0.006127Inherited
TNF-like0.007483Inherited
MHC antigen-recognition domain0.01469Inherited
Leucine zipper domain0.04166Inherited
STAT0.05099Inherited
Transcription factor STAT-4 N-domain0.05099Inherited
Frizzled cysteine-rich domain0.07623Inherited
Notch domain0.0965Inherited
Bcl-2 inhibitors of programmed cell death0.1186Inherited
HD-domain/PDEase-like0.1222Inherited
Integrin domains0.1369Inherited
ABC transporter transmembrane region0.1369Inherited
DPP6 N-terminal domain-like0.1668Inherited
Toll/Interleukin receptor TIR domain0.1857Inherited
Interleukin 8-like chemokines0.1982Inherited
SOCS box-like0.2531Inherited
Kringle-like0.3516Inherited
PGBD-like0.4501Inherited
TIMP-like0.4649Inherited
Hemopexin-like domain0.7311Inherited
Cystine-knot cytokines0.7451Inherited
Arginase/deacetylase0.7543Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
TAFH domain-like0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
BAFF receptor-like0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
DNA ligase0Direct
Inhibitor of apoptosis (IAP) repeat0.0001004Direct
A DNA-binding domain in eukaryotic transcription factors0.0001342Direct
C2 set domains0.0001342Direct
Short-chain cytokines0.0001629Direct
TNF receptor-like0.0005219Direct
SH2 domain0.00391Inherited
I set domains0.003934Inherited
Defensin0.004819Inherited
C1 set domains (antibody constant domain-like)0.005224Inherited
Nucleoside diphosphate kinase, NDK0.006197Inherited
TNF-like0.006536Inherited
MHC antigen-recognition domain0.01165Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.01207Inherited
Interleukin-1 (IL-1)0.02685Inherited
Leucine zipper domain0.03542Inherited
STAT DNA-binding domain0.04105Inherited
Transcription factor STAT-4 N-domain0.04105Inherited
STAT0.04105Inherited
PDEase0.062Inherited
Frizzled cysteine-rich domain0.06406Inherited
DEATH effector domain, DED0.07985Inherited
DPP6 N-terminal domain-like0.07985Inherited
Notch domain0.07985Inherited
Bcl-2 inhibitors of programmed cell death0.1012Inherited
ABC transporter transmembrane region0.1182Inherited
Integrin domains0.1182Inherited
L domain0.1184Inherited
ABC transporter ATPase domain-like0.1319Inherited
Fibronectin type II module0.1415Inherited
Toll/Interleukin receptor TIR domain0.1427Inherited
Interleukin 8-like chemokines0.1779Inherited
SOCS box-like0.2248Inherited
MMP N-terminal domain0.4212Inherited
Histone deacetylase, HDAC0.4847Inherited
Matrix metalloproteases, catalytic domain0.5089Inherited
Hemopexin-like domain0.7026Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
TAFH domain-like0Direct
Immunoglobulin0.00000007464Direct
TNF receptor-like0.00005599Direct
Inhibitor of apoptosis (IAP) repeat0.0000783Direct
A DNA-binding domain in eukaryotic transcription factors0.0001036Direct
4-helical cytokines0.0003615Direct
SH2 domain0.003123Inherited
p53-like transcription factors0.003786Inherited
Defensin-like0.004196Inherited
TNF-like0.005157Inherited
MHC antigen-recognition domain0.01043Inherited
Nucleoside diphosphate kinase, NDK0.01765Inherited
Leucine zipper domain0.03134Inherited
Transcription factor STAT-4 N-domain0.03877Inherited
STAT0.03877Inherited
Frizzled cysteine-rich domain0.05958Inherited
Notch domain0.07653Inherited
Bcl-2 inhibitors of programmed cell death0.09486Inherited
HD-domain/PDEase-like0.09797Inherited
Integrin domains0.1104Inherited
ABC transporter transmembrane region0.1104Inherited
DPP6 N-terminal domain-like0.1358Inherited
Toll/Interleukin receptor TIR domain0.1523Inherited
Interleukin 8-like chemokines0.1634Inherited
SOCS box-like0.2124Inherited
Kringle-like0.3023Inherited
Cytokine0.308Inherited
PGBD-like0.3921Inherited
TIMP-like0.4063Inherited
Hemopexin-like domain0.6593Inherited
Cystine-knot cytokines0.673Inherited
Arginase/deacetylase0.6818Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.0001036Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0002097Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0003383Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0004458Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0004888Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.005338Inherited
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0.00559Inherited
    82199,57667
  • 82199 - SET domain
  • 57667 - beta-beta-alpha zinc fingers
  • 0.00559Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.008Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.01017Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.01017Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.01269Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.01683Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.03696Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03877Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.03877Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03877Inherited
    82171,53474
  • 82171 - DPP6 N-terminal domain-like
  • 53474 - alpha/beta-Hydrolases
  • 0.07653Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1104Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.1131Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.1131Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.134Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.3921Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0.00559Inherited
    82199,57667,57667
  • 82199 - SET domain
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.00559Inherited
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.00559Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.01017Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03877Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03877Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.1131Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.1925Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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