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Disease Ontology (DO): neurodegenerative disease

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   disease [DOID:4] <8>
+ + + 3:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ + 2:   nervous system disease [DOID:863] <11>(51|61) (54|28|13)
+ 1:   central nervous system disease [DOID:331] <16>(33|44) (36|21|9)
0:   neurodegenerative disease [DOID:1289] <21>(24|31) (26|17|7)
- 1:   pontocerebellar hypoplasia [DOID:0060264] <15>(0|0) (0|0|0)
- 1:   motor neuron disease [DOID:231] <7>(5|4) (5|2|1)
- 1:   neurodegeneration with brain iron accumulation [DOID:0110734] <7>(0|0) (0|0|0)
- 1:   hereditary ataxia [DOID:0050951] <5>(2|1) (2|1|0)
- 1:   demyelinating disease [DOID:3213] <3>(9|14) (10|5|1)
- 1:   synucleinopathy [DOID:0050890] <3>(4|5) (4|1|0)
- 1:   neuroacanthocytosis [DOID:0050765] <1>(0|0) (0|0|0)
- 1:   secondary Parkinson disease [DOID:13548] <1>(0|0) (0|0|0)
- 1:   tauopathy [DOID:680] <1>(3|8) (4|6|4)
- 1:   Huntington disease-like 2 [DOID:0090104](0|0) (0|0|0)
- 1:   Huntington's disease [DOID:12858](0|0) (0|0|0)
- 1:   Lafora disease [DOID:3534](0|0) (0|0|0)
- 1:   Pick's disease [DOID:11870](1|1) (1|0|0)
- 1:   SPOAN syndrome [DOID:0060491](0|0) (0|0|0)
- 1:   agenesis of the corpus callosum with peripheral neuropathy [DOID:0090003](0|0) (0|0|0)
- 1:   familial encephalopathy with neuroserpin inclusion bodies [DOID:0050831](0|0) (0|0|0)
- 1:   infantile cerebellar-retinal degeneration [DOID:0050883](0|0) (0|0|0)
- 1:   myoclonic cerebellar dyssynergia [DOID:12707](0|0) (0|0|0)
- 1:   olivopontocerebellar atrophy [DOID:14784](0|0) (0|0|0)
- 1:   plexopathy [DOID:3688](0|0) (0|0|0)
- 1:   primary cerebellar degeneration [DOID:9277](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Synuclein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Flavoproteins0.00001437Direct
Cation efflux protein transmembrane domain-like0.002606Inherited
Inhibitor of apoptosis (IAP) repeat0.004807Inherited
Calcium-dependent phosphotriesterase0.008424Inherited
Proton glutamate symport protein0.01772Inherited
Insulin-like0.01772Inherited
YWTD domain0.01836Inherited
TNF receptor-like0.02235Inherited
Nudix0.03066Inherited
MHC antigen-recognition domain0.04129Inherited
Thioredoxin-like0.05096Inherited
Immunoglobulin0.06151Inherited
Periplasmic binding protein-like II0.09645Inherited
Protein kinase-like (PK-like)0.1234Inherited
SCOP hierarchy in SUPERFAMILY0.2255Inherited
4-helical cytokines0.3543Inherited
Interleukin 8-like chemokines0.3588Inherited
TNF-like0.4165Inherited
Fibronectin type III0.4827Inherited
Periplasmic binding protein-like I0.6524Inherited
Nicotinic receptor ligand binding domain-like1Inherited
Neurotransmitter-gated ion-channel transmembrane pore1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Serum paraoxonase/arylesterase 1, PON10Direct
Synuclein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Transferrin0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0003693Direct
NADPH-cytochrome p450 reductase-like0.0003693Direct
Cytochrome p450 reductase N-terminal domain-like0.001986Inherited
Cation efflux protein transmembrane domain-like0.001986Inherited
Interleukin 17F, IL-17F0.001986Inherited
Inhibitor of apoptosis (IAP) repeat0.003855Inherited
TNF receptor-like0.008729Inherited
Proton glutamate symport protein0.0146Inherited
Insulin-like0.0146Inherited
YWTD domain0.01589Inherited
Alpha-macroglobulin receptor domain0.0258Inherited
Complement components0.0258Inherited
C1 set domains (antibody constant domain-like)0.03351Inherited
MHC antigen-recognition domain0.03351Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.05741Inherited
V set domains (antibody variable domain-like)0.08274Inherited
Phosphate binding protein-like0.1564Inherited
Long-chain cytokines0.2411Inherited
Glutathione peroxidase-like0.2411Inherited
Interleukin 8-like chemokines0.3268Inherited
Pentraxin (pentaxin)0.371Inherited
TNF-like0.3834Inherited
Fibronectin type III0.457Inherited
C2 set domains0.5965Inherited
L-arabinose binding protein-like0.7314Inherited
Nicotinic receptor ligand binding domain-like1Inherited
Neurotransmitter-gated ion-channel transmembrane pore1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Synuclein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Flavoproteins0.00000793Direct
Cation efflux protein transmembrane domain-like0.001716Inherited
Inhibitor of apoptosis (IAP) repeat0.00325Inherited
Calcium-dependent phosphotriesterase0.005787Inherited
Lipoxigenase0.01273Inherited
Proton glutamate symport protein0.01273Inherited
Insulin-like0.01273Inherited
YWTD domain0.01321Inherited
TNF receptor-like0.01626Inherited
Alpha-macroglobulin receptor domain0.0228Inherited
Nudix0.0228Inherited
MHC antigen-recognition domain0.03105Inherited
Thioredoxin-like0.03877Inherited
Immunoglobulin0.04737Inherited
Periplasmic binding protein-like II0.0765Inherited
Protein kinase-like (PK-like)0.09899Inherited
4-helical cytokines0.3047Inherited
Interleukin 8-like chemokines0.3083Inherited
TNF-like0.3613Inherited
Fibronectin type III0.4232Inherited
ARM repeat0.4595Inherited
Periplasmic binding protein-like I0.5824Inherited
Nicotinic receptor ligand binding domain-like1Inherited
Neurotransmitter-gated ion-channel transmembrane pore1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    53850,53850
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.0002983Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.0002983Direct
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.004486Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.004936Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.005787Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.005787Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.01273Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.03105Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.08127Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.1846Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2074Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.5824Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.001716Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.001716Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.002807Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.2858Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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