SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Disease Ontology (DO): breast cancer

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   disease [DOID:4] <8>
+ + + + 4:   disease of cellular proliferation [DOID:14566] <3>(123|191) (129|118|56)
+ + + 3:   cancer [DOID:162] <2>(115|181) (120|113|54)
+ + 2:   organ system cancer [DOID:0050686] <14>(66|106) (72|58|31)
+ 1:   thoracic cancer [DOID:5093] <3>(10|17) (13|12|7)
0:   breast cancer [DOID:1612] <18>(10|17) (13|12|7)
- 1:   breast carcinoma [DOID:3459] <17>(5|9) (8|9|5)
- 1:   breast sarcoma [DOID:3017] <7>(0|0) (0|0|0)
- 1:   female breast cancer [DOID:0050671] <7>(0|0) (0|0|0)
- 1:   breast myoepithelial neoplasm [DOID:3004] <2>(0|0) (0|0|0)
- 1:   Her2-receptor negative breast cancer [DOID:0060080](0|0) (0|0|0)
- 1:   Her2-receptor positive breast cancer [DOID:0060079](0|0) (0|0|0)
- 1:   breast granular cell tumor [DOID:3011](0|0) (0|0|0)
- 1:   breast large cell neuroendocrine carcinoma [DOID:6657](0|0) (0|0|0)
- 1:   breast lymphoma [DOID:5826](0|0) (0|0|0)
- 1:   breast malignant eccrine spiradenoma [DOID:7983](0|0) (0|0|0)
- 1:   breast malignant phyllodes tumor [DOID:3016](0|0) (0|0|0)
- 1:   estrogen-receptor negative breast cancer [DOID:0060076](0|0) (0|0|0)
- 1:   estrogen-receptor positive breast cancer [DOID:0060075](0|0) (0|0|0)
- 1:   male breast cancer [DOID:1614](0|0) (0|0|0)
- 1:   malignant breast melanoma [DOID:4364](0|0) (0|0|0)
- 1:   progesterone-receptor negative breast cancer [DOID:0060078](0|0) (0|0|0)
- 1:   progesterone-receptor positive breast cancer [DOID:0060077](0|0) (0|0|0)
- 1:   triple-receptor negative breast cancer [DOID:0060081](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Protein kinase-like (PK-like)0.0000000002208Direct
Metalloproteases ("zincins"), catalytic domain0.00006099Direct
Integrin domains0.0002872Direct
PGBD-like0.0003569Direct
TNF receptor-like0.0004218Direct
SH2 domain0.000961Direct
SAM/Pointed domain0.004605Inherited
p53-like transcription factors0.008714Inherited
Kringle-like0.009107Inherited
Nuclear receptor ligand-binding domain0.07169Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Protein kinases, catalytic subunit0.00000002031Direct
Long-chain cytokines0.000006329Direct
L domain0.000006411Direct
TNF receptor-like0.0001206Direct
Ephrin receptor ligand binding domain0.0001877Direct
S100 proteins0.0001877Direct
Integrin domains0.0002808Direct
MMP N-terminal domain0.0003317Direct
Uteroglobin-like0.0004624Direct
Pointed domain0.0006823Direct
PB1 domain0.0006823Direct
Reprolysin-like0.001112Inherited
Blood coagulation inhibitor (disintegrin)0.002516Inherited
SAM (sterile alpha motif) domain0.01084Inherited
Nuclear receptor0.05965Inherited
Kringle modules0.069Inherited
Nuclear receptor ligand-binding domain0.07323Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Protein kinase-like (PK-like)0.0000000001023Direct
Metalloproteases ("zincins"), catalytic domain0.00003548Direct
Integrin domains0.0001738Direct
PGBD-like0.0002165Direct
TNF receptor-like0.0002576Direct
SH2 domain0.0006026Direct
Uteroglobin-like0.001359Inherited
Blood coagulation inhibitor (disintegrin)0.001871Inherited
SAM/Pointed domain0.003114Inherited
p53-like transcription factors0.005992Inherited
Kringle-like0.006303Inherited
BRCT domain0.01535Inherited
Nuclear receptor ligand-binding domain0.0558Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.000004214Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.000004214Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.00004461Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.0001252Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0002165Direct
    103575,81296
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 0.0003625Direct
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0.0003794Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.001122Inherited
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.001359Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.001871Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.002069Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.01466Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.000004214Direct
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.0003625Direct
    103575,81296,81296
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.0003625Direct
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.0003995Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.001122Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.002069Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)