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Disease Ontology (DO): cancer

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   disease [DOID:4] <8>
+ 1:   disease of cellular proliferation [DOID:14566] <3>(123|191) (129|118|56)
0:   cancer [DOID:162] <2>(115|181) (120|113|54)
- 1:   organ system cancer [DOID:0050686] <14>(66|106) (72|58|31)
- 1:   cell type cancer [DOID:0050687] <11>(23|40) (25|27|17)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Calpain large subunit, middle domain (domain III)0Direct
Purine and uridine phosphorylases0Direct
SPOC domain-like0Direct
Metallothionein0Direct
Apolipoprotein A-I0Direct
DNA-glycosylase0Direct
Alanine racemase C-terminal domain-like0Direct
FAD-dependent thiol oxidase0Direct
G protein-binding domain0Direct
FAS1 domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Zn-binding ribosomal proteins0Direct
BAG domain0Direct
Synuclein0Direct
Nuclear receptor coactivator interlocking domain0Direct
Sialidases0Direct
HSP90 C-terminal domain0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
post-AAA+ oligomerization domain-like0Direct
Annexin0Direct
14-3-3 protein0Direct
Polo-box domain0Direct
LeuD/IlvD-like0Direct
Flavoproteins0Direct
DNA polymerase beta, N-terminal domain-like0Direct
p53 tetramerization domain0Direct
HIT-like0Direct
Integrin beta tail domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Aconitase iron-sulfur domain0Direct
Phosphoglycerate mutase-like0Direct
Insulin-like0Direct
alpha-ketoacid dehydrogenase kinase, N-terminal domain0Direct
GroES-like0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
Restriction endonuclease-like0Direct
Serine protease inhibitors0Direct
Rap/Ran-GAP0Direct
Proteasome activator0Direct
PLP-binding barrel0Direct
Triple coiled coil domain of C-type lectins0Direct
DNA clamp0Direct
Di-copper centre-containing domain0Direct
PAZ domain0Direct
CCHHC domain0Direct
Uteroglobin-like0Direct
SMAD MH1 domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Serum albumin-like0Direct
NAD(P)-linked oxidoreductase0Direct
PP2C-like0Direct
TAFH domain-like0Direct
SRF-like0Direct
Orange domain-like0Direct
Transferrin receptor-like dimerisation domain0Direct
ACP-like0Direct
BTG domain-like0Direct
Plakin repeat0Direct
Uracil-DNA glycosylase-like0Direct
PLC-like phosphodiesterases0Direct
Nuclear receptor ligand-binding domain0.00001505Direct
Integrin domains0.002054Inherited
PGBD-like0.007263Inherited
TIMP-like0.009894Inherited
Growth factor receptor domain0.01126Inherited
HLH, helix-loop-helix DNA-binding domain0.01248Inherited
HMG-box0.01467Inherited
Arginase/deacetylase0.01813Inherited
Caspase-like0.01813Inherited
4-helical cytokines0.02814Inherited
Bcl-2 inhibitors of programmed cell death0.03325Inherited
TNF receptor-like0.03867Inherited
Hemopexin-like domain0.04885Inherited
Snake toxin-like0.04885Inherited
Metalloproteases ("zincins"), catalytic domain0.05053Inherited
Thyroglobulin type-1 domain0.05104Inherited
SOCS box-like0.06079Inherited
Ran binding protein zinc finger-like0.08566Inherited
Blood coagulation inhibitor (disintegrin)0.1101Inherited
Galactose-binding domain-like0.1315Inherited
Protein kinase-like (PK-like)0.2049Inherited
Kringle-like0.2154Inherited
Toll/Interleukin receptor TIR domain0.2532Inherited
Notch domain0.2672Inherited
Thioredoxin-like0.2677Inherited
A DNA-binding domain in eukaryotic transcription factors0.2836Inherited
p53-like transcription factors0.2964Inherited
Nucleotide-diphospho-sugar transferases0.2964Inherited
Defensin-like0.3536Inherited
Prefoldin0.3975Inherited
Transcription factor STAT-4 N-domain0.4365Inherited
STAT0.4365Inherited
TSP-1 type 1 repeat0.442Inherited
MHC antigen-recognition domain0.4642Inherited
Interleukin 8-like chemokines0.4991Inherited
Immunoglobulin0.6044Inherited
ABC transporter transmembrane region0.6116Inherited
DNA repair protein MutS, domain III0.6464Inherited
TNF-like0.6688Inherited
Cystine-knot cytokines0.6944Inherited
SAM/Pointed domain0.7153Inherited
Leucine zipper domain0.7747Inherited
DPP6 N-terminal domain-like0.8176Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.838Inherited
alpha/beta-Hydrolases0.8412Inherited
Ubiquitin-like0.8504Inherited
Cyclin-like0.8739Inherited
SH2 domain0.8823Inherited
Second domain of FERM0.8926Inherited
FnI-like domain0.9092Inherited
Ankyrin repeat0.9314Inherited
Frizzled cysteine-rich domain0.935Inherited
Intermediate filament protein, coiled coil region0.963Inherited
HD-domain/PDEase-like1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Aconitase iron-sulfur domain0Direct
BAG domain0Direct
Calpain large subunit, middle domain (domain III)0Direct
Prohormone convertase 1 pro-domain0Direct
SRF-like0Direct
UDPGT-like0Direct
Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain0Direct
Annexin0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
Ricin B-like0Direct
Prokaryotic proteases0Direct
Proprotein convertase P-domain0Direct
Chromo barrel domain0Direct
Ephrin receptor ligand binding domain0Direct
DNA polymerase beta-like0Direct
p53 DNA-binding domain-like0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Polo-box duplicated region0Direct
STAR domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Hairy Orange domain0Direct
Synuclein0Direct
Tissue inhibitor of metalloproteinases, TIMP0Direct
DIX domain0Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0Direct
Epoxide hydrolase0Direct
XPF/Rad1/Mus81 nuclease0Direct
Retinoblastoma tumor suppressor domains0Direct
BTG domain-like0Direct
DNA ligase0Direct
L30e/L7ae ribosomal proteins0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Bee venom hyaluronidase0Direct
L domain0Direct
Insulin-like0Direct
HSP90 C-terminal domain0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
Metallothionein0Direct
FAD-dependent thiol oxidase0Direct
Sialidases (neuraminidases)0Direct
PA domain0Direct
Transferrin0Direct
Neurotrophin0Direct
MutT-like0Direct
PAZ domain0Direct
FAS1 domain0Direct
AlkB-like0Direct
DNA polymerase beta, N-terminal domain-like0Direct
TAFH domain-like0Direct
p53 tetramerization domain0Direct
ZZ domain0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
C2 set domains0Direct
PP2C-like0Direct
Serum albumin-like0Direct
DNA gyrase/MutL, second domain0Direct
Platelet-derived growth factor-like0Direct
Integrin beta tail domain0Direct
FolH catalytic domain-like0Direct
Mammalian PLC0Direct
Purine and uridine phosphorylases0Direct
Eukaryotic ODC-like0Direct
Triple coiled coil domain of C-type lectins0Direct
BAFF receptor-like0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
Gelsolin-like0Direct
Arginase-like amidino hydrolases0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Multidomain cupredoxins0Direct
Uteroglobin-like0Direct
Short-chain cytokines0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Transferrin receptor-like dimerisation domain0Direct
Alanine racemase-like, N-terminal domain0Direct
Rap/Ran-GAP0Direct
CAD domain0Direct
alpha-ketoacid dehydrogenase kinase, C-terminal domain0Direct
Lesion bypass DNA polymerase (Y-family), catalytic domain0Direct
SMAD domain0Direct
GABARAP-like0Direct
DNA gyrase/MutL, N-terminal domain0Direct
Arginine methyltransferase0Direct
Adenain-like0Direct
MIF4G domain-like0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Aldo-keto reductases (NADP)0Direct
Ras-binding domain, RBD0Direct
Apolipoprotein A-I0Direct
DNA polymerase III clamp loader subunits, C-terminal domain0Direct
CCHHC domain0Direct
Methyl-CpG-binding domain, MBD0Direct
Erythroid transcription factor GATA-10Direct
alpha-ketoacid dehydrogenase kinase, N-terminal domain0Direct
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain0Direct
Integrin beta EGF-like domains0Direct
POU-specific domain0Direct
Cystatins0Direct
NADPH-cytochrome p450 reductase-like0Direct
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain0Direct
LeuD-like0Direct
HtrA-like serine proteases0Direct
SMAD MH1 domain0Direct
5' to 3' exonuclease catalytic domain0Direct
Extracellular domain of cell surface receptors0Direct
Hsp90 middle domain0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
14-3-3 protein0Direct
Nuclear receptor coactivator interlocking domain0Direct
Plakin repeat0Direct
DEATH effector domain, DED0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
Proteasome activator0Direct
Nuclear receptor ligand-binding domain0.00001196Direct
Nuclear receptor0.00002363Direct
Growth factor receptor domain0.0007262Direct
Integrin domains0.001552Inherited
Matrix metalloproteases, catalytic domain0.002141Inherited
MMP N-terminal domain0.00559Inherited
HLH, helix-loop-helix DNA-binding domain0.01106Inherited
HMG-box0.01193Inherited
Caspase catalytic domain0.02677Inherited
Bcl-2 inhibitors of programmed cell death0.02677Inherited
S100 proteins0.02677Inherited
Histone deacetylase, HDAC0.03684Inherited
Long-chain cytokines0.03684Inherited
Hemopexin-like domain0.0412Inherited
Thyroglobulin type-1 domain0.04276Inherited
SAM (sterile alpha motif) domain0.05037Inherited
SOCS box-like0.05037Inherited
TNF receptor-like0.06678Inherited
Paired domain0.06876Inherited
Ran binding protein zinc finger-like0.073Inherited
Blood coagulation inhibitor (disintegrin)0.09461Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.09461Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.122Inherited
Ephrin ectodomain0.1276Inherited
PB1 domain0.1276Inherited
ABC transporter transmembrane region0.1356Inherited
First domain of FERM0.1661Inherited
EGF-type module0.1773Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.2011Inherited
Fibronectin type II module0.2011Inherited
Protein kinases, catalytic subunit0.2083Inherited
Notch domain0.2371Inherited
A DNA-binding domain in eukaryotic transcription factors0.2552Inherited
Toll/Interleukin receptor TIR domain0.2734Inherited
C1 set domains (antibody constant domain-like)0.2995Inherited
Hexokinase0.3223Inherited
Nucleoside diphosphate kinase, NDK0.3223Inherited
Defensin0.3225Inherited
Third domain of FERM0.3964Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3984Inherited
STAT0.4036Inherited
Transcription factor STAT-4 N-domain0.4036Inherited
STAT DNA-binding domain0.4036Inherited
Kringle modules0.4064Inherited
TSP-1 type 1 repeat0.4237Inherited
I set domains0.4343Inherited
MHC antigen-recognition domain0.4438Inherited
Eukaryotic proteases0.4738Inherited
Interleukin 8-like chemokines0.482Inherited
DPP6 N-terminal domain-like0.4993Inherited
Reprolysin-like0.5307Inherited
DPP6 catalytic domain-like0.6099Inherited
DNA repair protein MutS, domain III0.6099Inherited
TNF-like0.6466Inherited
Leucine zipper domain0.737Inherited
Transforming growth factor (TGF)-beta0.8064Inherited
SH2 domain0.8503Inherited
ABC transporter ATPase domain-like0.8658Inherited
Interleukin-1 (IL-1)0.8662Inherited
Second domain of FERM0.8695Inherited
PDEase0.8831Inherited
Cyclin0.898Inherited
Frizzled cysteine-rich domain0.9064Inherited
Ankyrin repeat0.9125Inherited
Fatty acid binding protein-like0.9371Inherited
FHA domain0.9459Inherited
Intermediate filament protein, coiled coil region0.9489Inherited
Pointed domain0.9884Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Uracil-DNA glycosylase-like0Direct
Triple coiled coil domain of C-type lectins0Direct
Proteasome activator0Direct
DNA clamp0Direct
DNA polymerase beta, N-terminal domain-like0Direct
HSP90 C-terminal domain0Direct
p53 tetramerization domain0Direct
ACP-like0Direct
Purine and uridine phosphorylases0Direct
NAD(P)-linked oxidoreductase0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
Serum albumin-like0Direct
Aconitase iron-sulfur domain0Direct
14-3-3 protein0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
HIT-like0Direct
Apolipoprotein A-I0Direct
CCHHC domain0Direct
GroES-like0Direct
FAD-dependent thiol oxidase0Direct
Lesion bypass DNA polymerase (Y-family), little finger domain0Direct
BTG domain-like0Direct
Polo-box domain0Direct
Serine protease inhibitors0Direct
SRF-like0Direct
Rap/Ran-GAP0Direct
PAZ domain0Direct
PP2C-like0Direct
Orange domain-like0Direct
PLC-like phosphodiesterases0Direct
Metallothionein0Direct
Nuclear receptor coactivator interlocking domain0Direct
G protein-binding domain0Direct
Calpain large subunit, middle domain (domain III)0Direct
PLP-binding barrel0Direct
Di-copper centre-containing domain0Direct
Insulin-like0Direct
TAFH domain-like0Direct
LeuD/IlvD-like0Direct
FAS1 domain0Direct
Transferrin receptor-like dimerisation domain0Direct
Sialidases0Direct
Uteroglobin-like0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
SPOC domain-like0Direct
post-AAA+ oligomerization domain-like0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Integrin beta tail domain0Direct
Annexin0Direct
Synuclein0Direct
Zn-binding ribosomal proteins0Direct
SMAD MH1 domain0Direct
Restriction endonuclease-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
BAG domain0Direct
DNA-glycosylase0Direct
alpha-ketoacid dehydrogenase kinase, N-terminal domain0Direct
Plakin repeat0Direct
Alanine racemase C-terminal domain-like0Direct
Phosphoglycerate mutase-like0Direct
Flavoproteins0Direct
Nuclear receptor ligand-binding domain0.000008326Direct
Integrin domains0.001337Inherited
PGBD-like0.004991Inherited
TIMP-like0.006887Inherited
Growth factor receptor domain0.007903Inherited
HLH, helix-loop-helix DNA-binding domain0.008789Inherited
HMG-box0.01041Inherited
Caspase-like0.01303Inherited
Arginase/deacetylase0.01303Inherited
4-helical cytokines0.0208Inherited
Bcl-2 inhibitors of programmed cell death0.02485Inherited
TNF receptor-like0.02899Inherited
Snake toxin-like0.03705Inherited
Hemopexin-like domain0.03705Inherited
Metalloproteases ("zincins"), catalytic domain0.03841Inherited
Thyroglobulin type-1 domain0.03882Inherited
SOCS box-like0.04676Inherited
BRCT domain0.04755Inherited
Ran binding protein zinc finger-like0.06743Inherited
Blood coagulation inhibitor (disintegrin)0.08774Inherited
Galactose-binding domain-like0.1059Inherited
Protein kinase-like (PK-like)0.1694Inherited
Kringle-like0.1789Inherited
Toll/Interleukin receptor TIR domain0.2125Inherited
Notch domain0.2253Inherited
Thioredoxin-like0.2257Inherited
A DNA-binding domain in eukaryotic transcription factors0.2401Inherited
p53-like transcription factors0.2519Inherited
Nucleotide-diphospho-sugar transferases0.2519Inherited
Defensin-like0.3041Inherited
Prefoldin0.3438Inherited
STAT0.3797Inherited
Transcription factor STAT-4 N-domain0.3797Inherited
TSP-1 type 1 repeat0.3847Inherited
MHC antigen-recognition domain0.4055Inherited
Interleukin 8-like chemokines0.4386Inherited
Trypsin-like serine proteases0.4588Inherited
Immunoglobulin0.538Inherited
ABC transporter transmembrane region0.5448Inherited
DNA repair protein MutS, domain III0.5768Inherited
Nucleoside diphosphate kinase, NDK0.5768Inherited
TNF-like0.5979Inherited
Cystine-knot cytokines0.6231Inherited
SAM/Pointed domain0.6437Inherited
Cytokine0.6464Inherited
Leucine zipper domain0.703Inherited
EF-hand0.7255Inherited
DPP6 N-terminal domain-like0.7451Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.7656Inherited
alpha/beta-Hydrolases0.769Inherited
Ubiquitin-like0.7784Inherited
Cyclin-like0.8019Inherited
SH2 domain0.8102Inherited
Second domain of FERM0.8207Inherited
FnI-like domain0.8385Inherited
Ankyrin repeat0.8616Inherited
Frizzled cysteine-rich domain0.8655Inherited
Intermediate filament protein, coiled coil region0.8944Inherited
HD-domain/PDEase-like0.9516Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53448,50370
  • 53448 - Nucleotide-diphospho-sugar transferases
  • 50370 - Ricin B-like lectins
  • 0Direct
    82199,57903
  • 82199 - SET domain
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    52025,53187
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    57889,49562
  • 57889 - Cysteine-rich domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0Direct
    69012,55874
  • 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 0Direct
    54236,50729
  • 54236 - Ubiquitin-like
  • 50729 - PH domain-like
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0Direct
    52540,53254
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 53254 - Phosphoglycerate mutase-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    51045,56204
  • 51045 - WW domain
  • 56204 - Hect, E3 ligase catalytic domain
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    50044,56112
  • 50044 - SH3-domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0Direct
    57903,63748
  • 57903 - FYVE/PHD zinc finger
  • 63748 - Tudor/PWWP/MBT
  • 0Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    57184,100895
  • 57184 - Growth factor receptor domain
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    82615,82615
  • 82615 - Polo-box domain
  • 82615 - Polo-box domain
  • 0Direct
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0Direct
    46938,52087
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 0Direct
    53850,53850
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    53187,47672
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0Direct
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    50494,50156
  • 50494 - Trypsin-like serine proteases
  • 50156 - PDZ domain-like
  • 0Direct
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 0Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    54403,54403
  • 54403 - Cystatin/monellin
  • 54403 - Cystatin/monellin
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    63748,82199
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 0Direct
    50729,57863
  • 50729 - PH domain-like
  • 57863 - ArfGap/RecO-like zinc finger
  • 0Direct
    53732,52016
  • 53732 - Aconitase iron-sulfur domain
  • 52016 - LeuD/IlvD-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    51419,50621
  • 51419 - PLP-binding barrel
  • 50621 - Alanine racemase C-terminal domain-like
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    101690,53098
  • 101690 - PAZ domain
  • 53098 - Ribonuclease H-like
  • 0Direct
    82199,57667
  • 82199 - SET domain
  • 57667 - beta-beta-alpha zinc fingers
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0Direct
    57302,57302
  • 57302 - Snake toxin-like
  • 57302 - Snake toxin-like
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0Direct
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0Direct
    100895,47473
  • 100895 - Kazal-type serine protease inhibitors
  • 47473 - EF-hand
  • 0Direct
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00121Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.004991Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.006887Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.02238Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.06464Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.06464Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.07678Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.08774Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.08839Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.121Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.166Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.166Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.1885Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.2401Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.2519Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.3041Inherited
    103575,81296
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 0.3054Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3225Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.3797Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.3797Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.3797Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.3811Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3938Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.4177Inherited
    82171,53474
  • 82171 - DPP6 N-terminal domain-like
  • 53474 - alpha/beta-Hydrolases
  • 0.4708Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.5396Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.5448Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.5768Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.8747Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    57889,57889,49562
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    51045,51045,56204
  • 51045 - WW domain
  • 51045 - WW domain
  • 56204 - Hect, E3 ligase catalytic domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    54791,54791,54791
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 0Direct
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    63748,82199,57903
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    82199,57667,57667
  • 82199 - SET domain
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    47473,51695,49562
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0Direct
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    51045,51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 51045 - WW domain
  • 0Direct
    53067,53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    52025,53187,47672
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    57903,63748,82199
  • 57903 - FYVE/PHD zinc finger
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 0Direct
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    48552,48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    55753,55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    48726,49265,56112
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.01303Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.06464Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.06854Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.2519Inherited
    103575,81296,81296
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.3054Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.3797Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.3797Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.4976Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.7516Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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